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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_346310"/>
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            <end position="36"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59959.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
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    <sequence length="153" mass="16474" checksum="5772167967833994" modified="2013-05-01" version="1">MAEQDDPHTIDGESVRSSSPRRHSHTPSWEASSLLSPVGSQRASLDHKCYTQTLVSTLANPVEDGCRAQGSASTVTSNSASTLNEATSTQLPSLKNPLVQHWKTIAMIVGFILGGQSGLEQRYLHDPDCSSATFCLGALLACREPGWQAHRDE</sequence>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40245</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_40245"/>
    <dbReference type="HOGENOM" id="CLU_161483_0_0_1"/>
    <dbReference type="OMA" id="YCQFPAS"/>
    <dbReference type="OrthoDB" id="3690554at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="EMBL" id="EMD60619.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="145" mass="15186" checksum="B47F858B9DEA3D01" modified="2013-05-01" version="1">MHASSFIALALGATAVSAAAVAVDATPVSSAPVLSSERRQNACDPYCQFPKSLDCPGSGGVHIEQKDLIAAVVAGDRSQPPRETSAANLATRHCGELKTFPLWIADLPKRAGSVYYAVSPRGTFYYCGTSSGTHASGWPDQCKEN</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61354.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R287"/>
    <dbReference type="STRING" id="665912.M2R287"/>
    <dbReference type="GeneID" id="19134763"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_230425"/>
    <dbReference type="eggNOG" id="ENOG502SB51">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_072829_2_0_1"/>
    <dbReference type="OMA" id="FIDETCE"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
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    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR40422:SF1">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="132"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61354.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    <sequence length="132" mass="14841" checksum="6570D89E63DE561D" modified="2013-05-01" version="1">MSADAAPISFTRFSKALEDLSVESLYAKYSELTNQLMHLESSNQQLEEFAREHDDRDCYEALLENKQVMKRFEERKEAIKHEVQDVRGLPWRPKEDDGKTNGSAPTATNGAAREEGTNGTAAQDEGDDGVYL</sequence>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>M2RC63_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_89149</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700213.1">
        <property type="nucleotide sequence ID" value="XM_007702023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RC63"/>
    <dbReference type="GeneID" id="19141283"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89149"/>
    <dbReference type="HOGENOM" id="CLU_731856_0_0_1"/>
    <dbReference type="OMA" id="GCIDGMN"/>
    <dbReference type="OrthoDB" id="3935253at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="377" mass="42180" checksum="0DA0C8F5E0654A1F" modified="2013-05-01" version="1">MTLTNKDNNFFSSNKKYRTVREWLQKRVREAISRQRLKGAEEIVYIHQKTAPERLCTKPACVDVSKIDVIFFAPTTSVDSRHVSSRPPILPPIRPTRPDSSVFRDVNAWLEASANTPSPPLMSGISYWKETTVPNVKGSAVAQYAVPLSVAFGVARSTTATRQRTPCFRRLARKLQVQMPSILRTKSTHLPGKERRRRQSVCITPLSISYPNVQEDTTPVLITRSTSFLKPLILPLRRQTSARYGVLMSVSDSRECIPPRHGTPNSARFGDMDNDPERHVHQTFIRTGRGTDSARPPTALADLVCEDSVGDLSDAPTYSSGPPPPSYRSRCESMLTTSSFGCIDGMNPAQRQVSQQRVALQRGMRCKLKRLAQNFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RCU1</accession>
    <name>M2RCU1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tat pathway signal sequence protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_44294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699202.1">
        <property type="nucleotide sequence ID" value="XM_007701012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RCU1"/>
    <dbReference type="STRING" id="665912.M2RCU1"/>
    <dbReference type="GeneID" id="19140193"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_44294"/>
    <dbReference type="eggNOG" id="ENOG502RAW0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_6_0_1"/>
    <dbReference type="OMA" id="FRVSHIN"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="20012" checksum="73D590B497FA6651" modified="2013-05-01" version="1" fragment="single">ELDRSHILTQFSEHRVNGTSRWSAPPSPSVDRAWLELGVRDIGFLVPKAVGISHGLDPREQKYYPKGTYRSDSELEGFIVFVQAFHDLHCLDELRKALYFNKPYYRQYEDDNLVPEWFRVSHINHCLDNIRETLMCAADIGVIPTVWTGSHNSSIRFSNKHQCNSYDSLLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RGH8</accession>
    <name>M2RGH8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zygote-specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_35838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698411.1">
        <property type="nucleotide sequence ID" value="XM_007700221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RGH8"/>
    <dbReference type="STRING" id="665912.M2RGH8"/>
    <dbReference type="GeneID" id="19138556"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35838"/>
    <dbReference type="eggNOG" id="ENOG502S6ZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166294_1_0_1"/>
    <dbReference type="OMA" id="CAAVIMA"/>
    <dbReference type="OrthoDB" id="10063670at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475">
        <property type="entry name" value="ZYGOTE-SPECIFIC CLASS V COPY B GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475:SF1">
        <property type="entry name" value="ZYGOTE-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023977" description="Zygote-specific protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="7887" checksum="4B016A365E09FEEB" modified="2013-05-01" version="1">MALLLLITLITLAFASLASAGPAAYGLCQAGCSAVVMACYSAAGFTWGATLGASAPASIIACNTAFGTCQAACAAVVLTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2RGR2</accession>
    <name>M2RGR2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_311135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <sequence length="255" mass="27848" checksum="64FF22DB5749E76C" modified="2013-05-01" version="1">MKSGPTRSAHARDDTEFRYDLSHAIYGSFPSCASHTTPPQRSRAPSPHFASKASSEPTSSTLVDSTLSAQNEIQSPNDDNGDIDNDITNNSVIQPWLSHRPNPPSHADNMDNMHQSVCLNLTPPCETTTSESELWILPELDDCNANPSASSTSSSSTSSSSSSSSATTSPRPSTPLVVSGEKQISLFLSHATKAKSHFEQLRTRLIQGDYDGWDLFVARCSPESKDRPRNKHYHGEERVDEEFDLVVLSAVRASC</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <begin position="273"/>
            <end position="292"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="299" mass="34221" checksum="F54E73B7F127635F" modified="2013-05-01" version="1">MPLDDLLKNQISEPTRKEITHKLLENSSSTINLQYDGLDWKPYFSYYTEECSLAIGSDQHLLAATHQNIIAITKEIESTKTKNEIRVILPPEFDKDLTPDEARQKMERAIRLAARLLLIIDIGPLPANAYSGRSPLLWNQRSLKDCMQQFFAPPPQKYSRELKLQPLFTGRNLVRMAGIEIAWTDNLTDHLLLIDGDQRVCIFHHASFLNQLLPDGLAQETIGNLALLFPQSDPKTRRSVSGDVQLDLQLAFDESRPATILQWWHDRRDGVQWYIFWVAIVVLMLTIFFGLVQSIEGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQ93</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_276270</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="EMD68744.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="101" mass="11230" checksum="B98440C503ABEE5E" modified="2013-05-01" version="1">MPLGHERLCSAAIRWLYIHTVCNIPWAGHRPVRRPVRHRAAGQYLELTTLNVVLVSEAVSRVGWVAIGGCGLAVATPNLPQHGVHRCMHRWIAPVTRAFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQT2</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">ND90Pr / ATCC 201652</strain>
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    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 9"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696411.1">
        <property type="nucleotide sequence ID" value="XM_007698221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQT2"/>
    <dbReference type="SMR" id="M2RQT2"/>
    <dbReference type="GeneID" id="19130960"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_135278"/>
    <dbReference type="eggNOG" id="ENOG502RXA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045022_2_0_1"/>
    <dbReference type="OMA" id="NGPWAVN"/>
    <dbReference type="OrthoDB" id="10035502at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024319" description="Cellulase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 45 active site" evidence="11">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="228" mass="25047" checksum="0E536EDD92CD03C9" modified="2013-05-01" version="1">MLLTLARLSLAFSLLLHHVSGERGVTTRYWDCCKPSCAWPGKAKVSEPVRTCNKQDLWPTPLDANAASACGNGEAYTCSNNGPWAVNDNLAYGFAAANLKGKNEGDWCCACYELTFTSGPVNGKKMVVQVTNTGSDLKENQFDLAIPGGGVGIFPQGCAKQFNGAWMGNTFGGYWQRDHCYNLPAGAFRDGCFWRFDWFKNADNPSVDFREVSCPQAMIDRTHCGRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQU6</accession>
    <name>M2RQU6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_21238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694045.1">
        <property type="nucleotide sequence ID" value="XM_007695855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQU6"/>
    <dbReference type="GeneID" id="19134424"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_21238"/>
    <dbReference type="eggNOG" id="ENOG502SQ37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062687_0_0_1"/>
    <dbReference type="OMA" id="TICLFIQ"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="37"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="301" mass="34001" checksum="453E34B8F1A42D94" modified="2013-05-01" version="1">METSQQPPAGGDTSNATPGLVGVSCLLAIVIIVYGVRMYTRIRPVFKLGAPDYLVSAALVTISLGFGRPEYYLVPGTMVQIRKHLYALGFLGFWASSLARMSIGFMLLRFEASKTWRVVLKILIFTQLCLPISLDVIALIQCRPIRAMWEYVPDAVCWSLPRTQSYTYIYSAIGMLSDIVFAAIPIYFVWSLHRPVLERILISTLMALGLLAATAEACIIYHAYLWNPRESTIRDWMPLFWWYRVEEIGLIFAACTPFLKPLVERVLGRFGTSRFRFVTMELDSIQSSQVTKQEVVVMTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRW5</accession>
    <name>M2RRW5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GET complex subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_32061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694188.1">
        <property type="nucleotide sequence ID" value="XM_007695998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RRW5"/>
    <dbReference type="STRING" id="665912.M2RRW5"/>
    <dbReference type="GeneID" id="19136625"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32061"/>
    <dbReference type="eggNOG" id="ENOG502S1RY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_819228_0_0_1"/>
    <dbReference type="OMA" id="MRYGQIF"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="33166" checksum="414169FEF36C8AF9" modified="2013-05-01" version="1">MADSPASATGALPGESPAQTKARLRRERLAAKSGASRLQQITALQGGPPRDLSEVEKDVPVKPAPIPFPQRTPSRSGTATPDPDEVDISQHHYPPVSRPRLPSPFAPEANQTDPFGPGQASDPAQDPMMAMLQQMMGAGAGGMPGMPGGPGQAGAPPGLANMLSAMQGGGAVPEPSPDQSSAWIWRLVHSVFSLGLAVYIVLQTPFTGSKFLRDNVPDDDWTTQSSPADNFAHFFYLFATFEVILQSSRYFIEKGQLQGGGMLSTVAGILPEPYAGYVRTVGRYSVIYSTVVSDAMVVVFVLGATSWWKGAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RS62</accession>
    <name>M2RS62_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_33116</name>
        <name evidence="4" type="ORF">COCSADRAFT_42126</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr</strain>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445759">
        <property type="protein sequence ID" value="EMD58073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695455.1">
        <property type="nucleotide sequence ID" value="XM_007697265.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706227.1">
        <property type="nucleotide sequence ID" value="XM_007708037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RS62"/>
    <dbReference type="STRING" id="665912.M2RS62"/>
    <dbReference type="GeneID" id="19137041"/>
    <dbReference type="GeneID" id="19140171"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33116"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_42126"/>
    <dbReference type="HOGENOM" id="CLU_013929_6_0_1"/>
    <dbReference type="OrthoDB" id="3795213at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD68150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="341" mass="38954" checksum="A396826DEC783A50" modified="2013-05-01" version="1">MDGHHSHITMDFIDYCDQNKILLAIFPPHSTHTLQPLDIGLFKPLSTAYSNELSNFTDTSQGLIPFTKSHFFPIFWRAWCAAFKESSILHAFRATGLSPFNPEVILQKFRTIATNSDRDVSVESASNWRAIRQLLNQSTSSRSISALNRILMKLSADTAFLQRENEQLRAALIDERQRKERIQPGTLELSDDYHGGATFWSPRKVREARRQYEQKQRDHEELQRQKAIAVKAREERKLLKAQELDARRRARAQAKLDRERQKAEAAAHRIARQAAHKRLQKAIKISQRGKKPTFKRSTELASKNIIVGSSSGGAQRANRSAAPPSPRSRSGRPIKLPIKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSK8</accession>
    <name>M2RSK8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_211272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694848.1">
        <property type="nucleotide sequence ID" value="XM_007696658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSK8"/>
    <dbReference type="STRING" id="665912.M2RSK8"/>
    <dbReference type="GeneID" id="19134402"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_211272"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148322_4_2_1"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="98" mass="10945" checksum="F67406C731E5A180" modified="2013-05-01" version="1">MSENGSPNNMQQKPEDGGQSEHLNIKVTDNNNEVFFKIKRTTALGKLMNAFCDRQGKNISSVRFLFDGQRVTAQDNPDTLDMQDGDTLEVHQEQIGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT48</accession>
    <name>M2RT48_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">COCSADRAFT_106643</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694975.1">
        <property type="nucleotide sequence ID" value="XM_007696785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT48"/>
    <dbReference type="STRING" id="665912.M2RT48"/>
    <dbReference type="GeneID" id="19130001"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_106643"/>
    <dbReference type="eggNOG" id="KOG1819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022550_2_0_1"/>
    <dbReference type="OMA" id="CWCKFHE"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="194"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="548"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="289"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMD69739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="594" mass="65144" checksum="DDE89D82FB1C2943" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M2RTV6</accession>
    <name>M2RTV6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_76883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695182.1">
        <property type="nucleotide sequence ID" value="XM_007696992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RTV6"/>
    <dbReference type="STRING" id="665912.M2RTV6"/>
    <dbReference type="GeneID" id="19140587"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_76883"/>
    <dbReference type="eggNOG" id="ENOG502S3FG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007607_0_1_1"/>
    <dbReference type="OMA" id="DGMEEWQ"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="97" mass="10974" checksum="3BE4FA00ED2F19F3" modified="2013-05-01" version="1">MTVPNSYFVPGFGISRAVIQNEIRYHCGPDAIVRPYTFQGRDGFLITTIGPPLTKAQIEDLKMSSLEYEEKQSRIADETNVFVNAPIPITQRIRRST</sequence>
</entry>
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    <accession>M2RUM8</accession>
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            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_185388</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
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            <end position="436"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD58843.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUN4</accession>
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        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_128444</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59898.1"/>
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        <property type="nucleotide sequence ID" value="XM_007705997.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19130645"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_125974"/>
    <dbReference type="eggNOG" id="ENOG502STSC">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024846" evidence="2">
        <location>
            <begin position="19"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="525" mass="54024" checksum="5748248805D97F29" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2RYI9</accession>
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        <recommendedName>
            <fullName evidence="7">ACT domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_40517</name>
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    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
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    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="665912.M2RYI9"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_40517"/>
    <dbReference type="eggNOG" id="KOG2663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_0_0_1"/>
    <dbReference type="OMA" id="CARSGMM"/>
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    <dbReference type="UniPathway" id="UPA00047">
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    </dbReference>
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        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALS_ss_C"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD60088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="325" mass="36079" checksum="D6ED52F5F218830E" modified="2013-05-01" version="1">MASRRAVLPLRSLLNRQCAGTLRLQQRASSSSSTQALAYKALHRRIAPLPTEDRPPAWSAPAAVSNILYETPLPSQAPPKSHILNCLVQNEPGVLSRVSGILAARGFNIDSLVVCNTEVDDLSRMTIVLQGQDGVIEQARRQLEDLVPVWAVLDYTESPLVQRELLLAKVSILGPEYFEELLAHHREMAQPPETDRHETENMSEDERNAAAHEAARESLRKDYHPTNLPISQALRHKHEHLRAITFMTHQFGGKVLDISTNNCIVELSAKPTRIDSYMKLIAPFGILESARTGLMALPRSPLHNSAEIEEMEAQDVVDNSLLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2S0D8</accession>
    <name>M2S0D8_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_346090</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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            <end position="447"/>
        </location>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
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        <name evidence="9" type="ORF">COCSADRAFT_39877</name>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Rnh202_N"/>
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    </dbReference>
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        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="315"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
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            <begin position="9"/>
            <end position="26"/>
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    </evidence>
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        <source>
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        </source>
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            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_39381"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="330" mass="36046" checksum="3767488776823851" modified="2013-05-01" version="1">MPQLVGKMVGPVGYGLMGLTWRPDPPSQEQSFEAMRTALSLGANNWNGGELYGTPERNSLHLLNEYFTKYPEDADKVVLSIKGGLKKGELTPDGSRENVRRSIDECLRLLDGKKSLDLFECARVDLNTPIQDTISYIAEYVKEGKLGGISLSEVGAQSIRKAHSVHPISAVEVEFSLWSTDILENGVAATCAELGIPIIAYSPLGRGFLTGKYKKHSDIEPGSLLHHMPRFQPEVFDENIKLLHAVEDLAKSKGVTPAQIAIGWVLAHSGAKGMPTIIPIPGATTSQRVEENLKPAKLNDEDMKALEEILKKFPVIGGRYNEAQAALMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2S927</accession>
    <name>M2S927_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_358386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700848.1">
        <property type="nucleotide sequence ID" value="XM_007702658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S927"/>
    <dbReference type="GeneID" id="19138557"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_358386"/>
    <dbReference type="HOGENOM" id="CLU_2072945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024821" evidence="1">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="118" mass="12583" checksum="0D0D6DB6C5309DDF" modified="2013-05-01" version="1">MKFSLAASILFLASTVSEHFFPHLLEKKIIRIFSANESPASRQPTTVIALDQDLSQLHLDVLAASKLGNLRTLTVQPATASSPMEEIFNFAKVDSAAAARALGITAVSASRGTDGQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBV7</accession>
    <name>M2SBV7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">COCSADRAFT_36171</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699114.1">
        <property type="nucleotide sequence ID" value="XM_007700924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBV7"/>
    <dbReference type="STRING" id="665912.M2SBV7"/>
    <dbReference type="GeneID" id="19138677"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36171"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="OMA" id="YERGYAM"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024864" description="Probable beta-glucosidase G" evidence="19">
        <location>
            <begin position="22"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="732"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMD64788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="817" mass="88529" checksum="4B870C7B1A884643" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBW2</accession>
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            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_189836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701172.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SBW2"/>
    <dbReference type="GeneID" id="19133697"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_189836"/>
    <dbReference type="eggNOG" id="KOG1154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_1_1_1"/>
    <dbReference type="OMA" id="NLAFPPH"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD64793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SE15</accession>
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        <name evidence="5" type="ORF">COCSADRAFT_125833</name>
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    <organism evidence="5 6">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
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        <property type="nucleotide sequence ID" value="XM_007705802.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19130638"/>
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    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_2_2_1"/>
    <dbReference type="OMA" id="YTNFMSY"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF5">
        <property type="entry name" value="UDP-GLUCOSE,STEROL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="250"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="569"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
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            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66003.1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42007" checksum="65062230187B452B" modified="2013-05-01" version="1">MSRRHIEAHSPPHAEAERASSQAHPAAAIDSGIDVGSSSEFDQDNSAGHALVAHDDTSEASTDEGYADSDASSFLSSILSEVRRGVEIEGRLYPSYGKHAYGMPMDEKELDRNDLQHHKYTLLLRDRLFVAPVPESTFEDANCRVLDLGTGTGIWAIDMADKYPNAEILGVDIAATQPSFVPPNCLFEIDDVEEDWPYRPAHFDFIHGRDLMTAIRDWPRVIAQAYAHLKPGGWIQLASTIPGPLTDDNTIPENSGYVETARVYFEIAEKMGAPLAAPRDWNAQMKEAGFINVQDEVYKLPMGPWPRSKRLRTVGKLEQIMILEGGFEAYMLRGYTQVLGGKVEDLQIILALAKREVRDPSIHTYVQFHITYGQKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGA7</accession>
    <name>M2SGA7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_231894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702808.1">
        <property type="nucleotide sequence ID" value="XM_007704618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SGA7"/>
    <dbReference type="STRING" id="665912.M2SGA7"/>
    <dbReference type="GeneID" id="19134789"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_231894"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_10_2_1"/>
    <dbReference type="OMA" id="FMAYRPS"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="283"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="376"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="380"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD61470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="517" mass="57701" checksum="63E0351EA9DF5E03" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJ88</accession>
    <name>M2SJ88_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_352114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696960.1">
        <property type="nucleotide sequence ID" value="XM_007698770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJ88"/>
    <dbReference type="STRING" id="665912.M2SJ88"/>
    <dbReference type="GeneID" id="19138134"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352114"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045276_0_1_1"/>
    <dbReference type="OMA" id="HLMQVMD"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50908"/>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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    <dbReference type="GeneID" id="19138177"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352776"/>
    <dbReference type="eggNOG" id="ENOG502S0ES">
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        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="235"/>
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        <location>
            <position position="531"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="531" mass="59837" checksum="C5B0F8E4346D9F85" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLK0</accession>
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        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_33012</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695434.1">
        <property type="nucleotide sequence ID" value="XM_007697244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLK0"/>
    <dbReference type="STRING" id="665912.M2SLK0"/>
    <dbReference type="GeneID" id="19137001"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33012"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_2_1"/>
    <dbReference type="OMA" id="CVEPKQF"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF2">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="352" mass="38740" checksum="F29B53E0A8A1980A" modified="2013-05-01" version="1">MASILRVAACHASPVFLNARRTTDKAIALVKQAASNKANLVVFPETYISAFPIWSSLRPPTDNHWLFQRMVQESVYADGDELEAIREAARSSGVLVSIGFSEKSRHSNGCLYNSNLIIGTEGEVLVHHRKLVPTFFEKLTWSPGDGHGLRVASTQFGRIGTLICGENTNALARYSMIAQAEQVHISTWPAIWPTRTLQKIPPSAESGVHQASTRGANYDNLAANRTRAAAHCFEAKCFGVACSGHLGEDAIETIVDGASQPDVVTETLRAMPRAATFFLDPTGAPLPSFIYKDSQKQNTDALQSDEDILYADMRLEDCIEGKQYHDVVGGYQRLDVFDLKVDRSRKDPVKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLU6</accession>
    <name>M2SLU6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_104758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445727">
        <property type="protein sequence ID" value="EMD58106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706194.1">
        <property type="nucleotide sequence ID" value="XM_007708004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLU6"/>
    <dbReference type="GeneID" id="19129940"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104758"/>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="OrthoDB" id="5588148at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="49" mass="6037" checksum="8D88E0D4E1F3E7AA" modified="2013-05-01" version="1" fragment="single">INNALYKYLRIFVTAYLDNILVYSSGIREEYIKYIKKVLRKLKEYKLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLZ8</accession>
    <name>M2SLZ8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_270057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695869.1">
        <property type="nucleotide sequence ID" value="XM_007697679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLZ8"/>
    <dbReference type="STRING" id="665912.M2SLZ8"/>
    <dbReference type="GeneID" id="19135598"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_270057"/>
    <dbReference type="eggNOG" id="ENOG502S0GX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008693_0_0_1"/>
    <dbReference type="OMA" id="YWREGKC"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <source>
            <dbReference type="EMBL" id="EMD68373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="523" mass="56074" checksum="3633B8C9FFEFAC2E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMP2</accession>
    <name>M2SMP2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700394.1">
        <property type="nucleotide sequence ID" value="XM_007702204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMP2"/>
    <dbReference type="STRING" id="665912.M2SMP2"/>
    <dbReference type="GeneID" id="19138954"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37338"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_1_1"/>
    <dbReference type="OMA" id="GYPKMST"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000016">
        <property type="entry name" value="Nitrilase blr3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF12">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="344" mass="37482" checksum="832E9FD00AAD87E1" modified="2013-05-01" version="1">MATPSQPIYLAVCQKHTQSTTAETLEALSEQCLKASKADPSPDLILFPEAYIGGYPRGATFGAAVGGRTAEGREQYLNYYKDAVDLGDTPEGAGEKWVKRELEGQEEGSSGRVRRGDGTREKLEQVAKETGIFIVTGLVERSGGTLYCAVVYVCPKLGVIGKRRKVMPTGSERLIWGQGQPSSLRAVTTDIKGVHITLAAAICWENYMPLLRHSLYSQNVNLYLAPTADARETWSALMTTVACEGRCYVLSANQCLKKQNQPAWIYGEKAESEDFVSRGGSCIISPLGEILKGPLWEDDDSMMMVAADFDDCLRGRLDLDVAGSYSRNDSFKLSVTGLDISPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMV4</accession>
    <name>M2SMV4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_329879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700682.1">
        <property type="nucleotide sequence ID" value="XM_007702492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMV4"/>
    <dbReference type="STRING" id="665912.M2SMV4"/>
    <dbReference type="GeneID" id="19136992"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_329879"/>
    <dbReference type="eggNOG" id="KOG4574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005652_0_0_1"/>
    <dbReference type="OMA" id="MWEISQG"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000167">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="449"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="594"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="656"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="692"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="943"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1087"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1118" mass="120476" checksum="1DD758F7BA0ED629" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN29</accession>
    <name>M2SN29_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_165368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705651.1">
        <property type="nucleotide sequence ID" value="XM_007707461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN29"/>
    <dbReference type="STRING" id="665912.M2SN29"/>
    <dbReference type="GeneID" id="19132383"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_165368"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1598412_0_0_1"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19246" checksum="6906D8D669FCC9BB" modified="2013-05-01" version="1">MDPRLSTLPLSKNASDHQSYLNAIAAQLEDENSFFREAAVIALGKQPTLPSHILQGVATQLEDKEGAIRKSTLKVLDKQPNPPDSILRAVAGRIEDEFKFIRASTITALCKQPALPDDILKTLAALLGDKHSFAQAADIEILSKQPVFPNEIVEAVAAKLDDKDDFIHAAVVEKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPC2</accession>
    <name>M2SPC2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_153799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705444.1">
        <property type="nucleotide sequence ID" value="XM_007707254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPC2"/>
    <dbReference type="STRING" id="665912.M2SPC2"/>
    <dbReference type="GeneID" id="19131644"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_153799"/>
    <dbReference type="eggNOG" id="ENOG502SXYY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053381_7_0_1"/>
    <dbReference type="OMA" id="DMVAFNF"/>
    <dbReference type="OrthoDB" id="5421909at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025159" description="Phytocyanin domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="21308" checksum="D1A02DB4F7BABC36" modified="2013-05-01" version="1">MLFSTILYAALAQSLTASAATMMVTVAANNKFQFTPNSVTAQPGDTVAFNFVAQNHSVASSTANQPCQPGPNALFSDFQPIPGNPKGSPNPANGRRQAGNNPMFMVPITDNQPIYVYCPQAQHCQQGMVMVINPPNAAAVTQYQNAAAQANNNIPPNGGVNGGQMINSNAGTNPKNVLGAKAGDAAKGKGKKAGGAAAGGLAGLLGGLGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPF8</accession>
    <name>M2SPF8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2306 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_154217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705706.1">
        <property type="nucleotide sequence ID" value="XM_007707516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPF8"/>
    <dbReference type="STRING" id="665912.M2SPF8"/>
    <dbReference type="GeneID" id="19131658"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_154217"/>
    <dbReference type="eggNOG" id="ENOG502RYBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054818_0_1_1"/>
    <dbReference type="OMA" id="CIITTRI"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39010" checksum="52C231EDF249AD33" modified="2013-05-01" version="1">MVAKQPSSSTFARKIVNPLGFTKTYNFWLYFVFGGALLGFSLARLQYLAFSSKFCPADGPSSTGNSAAPGECYYYLNFNRFKVGILLHLGGILPAGIIAVLQFTPFIRHRWLILHRIGGYASLLLYLISLVGALMIIRHAFGGGLDVQSSLGALGVTTLGCFIISYINVKKLQIEQHRAWMLRGWFYAGCIITTRIIMIISAQIIKNSGYYTVWPCAKISATIEDGIDLVASYPACSAFVDGSNLDAVSAVAATIGSGDRANTGAALNIAFGMAVWLAFALHALGVEIYLHLTPREAQRLRQVSYQKQLEAGMRNPGSAGLTSDRLGDAERWSPDASRKDSTSPLTPGTPEPNPRVERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPI5</accession>
    <name>M2SPI5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_31876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694137.1">
        <property type="nucleotide sequence ID" value="XM_007695947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPI5"/>
    <dbReference type="STRING" id="665912.M2SPI5"/>
    <dbReference type="GeneID" id="19136564"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31876"/>
    <dbReference type="eggNOG" id="ENOG502RZAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_2_0_1"/>
    <dbReference type="OMA" id="NYVMSHG"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="291" mass="33460" checksum="DAD05FD525329882" modified="2013-05-01" version="1">MQETRRDSQSGDVVVPINYFPVTGIPIPNSAWKTPFLDDHNEHTRYMLIRDARTSGRTFDLDTNGFTFVTLPPKNRVTRESTEEEVKREYYPEIEETVKKLTGATTAHVFNHVIRAHTSPSEKGILDPKGRWQDIPSGHPHVDYAGSPSAIAGTQRELSLPPHISTLFTHSQRFAFLGAWRPLKPVHRDPLAVCDATSVPDSDYQIREREFSRTGIKSENYVMSHGEKERQVHQWWYLSNMMPDEMVVFKGFDTEREKPGWRCPHTAFRVPGSEGQEARESIEVRVVVFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ54</accession>
    <name>M2SQ54_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_166362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694714.1">
        <property type="nucleotide sequence ID" value="XM_007696524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ54"/>
    <dbReference type="STRING" id="665912.M2SQ54"/>
    <dbReference type="GeneID" id="19132445"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_166362"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="OMA" id="FREFPHE"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000040">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="318" mass="36236" checksum="EF8F340BA77892B8" modified="2013-05-01" version="1">MPGLPSSVDLDECISRLSKKELLAEPVIEAICAKTKELLMKESNVVHIRAPVTVVGDIHGQFFDMMEIFKIGGPCPDTNYLFLGDYVDRGLFSVETISLLVCLKLRYPHRVHLIRGNHESRGVTQSYGFYTECSRKYGNANVWHYFTDMFDFLTLSVVINDQIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMADLVWSDPDPERDEFSLSPRGAGYTFGAQVVKKFLEVNSMSHILRAHQLCQEGYQILYDDRLSTVWSAPNYCYRCGNMASVLEVSDTGERFFNVFDASPDNDIHRAEQQQQQQGKEVTTEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ85</accession>
    <name>M2SQ85_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_105885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694734.1">
        <property type="nucleotide sequence ID" value="XM_007696544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ85"/>
    <dbReference type="STRING" id="665912.M2SQ85"/>
    <dbReference type="GeneID" id="19129982"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_105885"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_3_1"/>
    <dbReference type="OMA" id="GMQPWKY"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="564" mass="62945" checksum="1012FBBFE2C4BBC8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ99</accession>
    <name>M2SQ99_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_72742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694744.1">
        <property type="nucleotide sequence ID" value="XM_007696554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ99"/>
    <dbReference type="STRING" id="665912.M2SQ99"/>
    <dbReference type="GeneID" id="19140495"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_72742"/>
    <dbReference type="eggNOG" id="ENOG502S3TP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085417_0_0_1"/>
    <dbReference type="OMA" id="DYARHDE"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="233" mass="26156" checksum="2AC6A959191E0409" modified="2013-05-01" version="1" fragment="single">TTHHTMASLAPEPDSTTPPPHKNPYPTSPRLDMPFDRRLLLTTTLSFLSGFTLGSLSAGHMASLRFRAENAHRLPTSNPGWYLYHKSKNYYKWRYGIVEGLRKGTYIAAWSMVFFVVEESLDVFRGTWRAGRTMEEMEGVDELDLKKIERGVSGSRDFVSSALAGMVTGGVWSAWHQFPVSTAARTIRLGLLVGLGFGLGQDGLVWAKARWGGGRESESWIYRGARNRRVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQK8</accession>
    <name>M2SQK8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_26703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699734.1">
        <property type="nucleotide sequence ID" value="XM_007701544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQK8"/>
    <dbReference type="GeneID" id="19135543"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_26703"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="OMA" id="KMIVHDR"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025697" description="Multicopper oxidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="153"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="367"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD64565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60130" checksum="71E3B1C1181695F8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR32</accession>
    <name>M2SR32_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_195480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694954.1">
        <property type="nucleotide sequence ID" value="XM_007696764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR32"/>
    <dbReference type="STRING" id="665912.M2SR32"/>
    <dbReference type="GeneID" id="19133938"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_195480"/>
    <dbReference type="eggNOG" id="KOG4066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065847_1_0_1"/>
    <dbReference type="OMA" id="DANPHFD"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="218" mass="23771" checksum="52C75906DBFD697A" modified="2013-05-01" version="1">MASVRTFQLPHYHAYPVHVALFKDVANASHLRRQLLDANPHFDYAFLDASMIVSPQHLLSATFIALHNFLTSRSKTRTPHSELVFRLSPNNNIGESYKKFGISDSSTAIIAVKLPLSASAPDGTYVKDESITNQTVSAHLGNVVHGSSIEIADNGQELGSYCQLDKVRKVYKLASADRASRSNTTTKQANGDNHGNDSQDEKAYIESLVLGAMALKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRV1</accession>
    <name>M2SRV1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_42289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699201.1">
        <property type="nucleotide sequence ID" value="XM_007701011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRV1"/>
    <dbReference type="STRING" id="665912.M2SRV1"/>
    <dbReference type="GeneID" id="19140179"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_42289"/>
    <dbReference type="eggNOG" id="ENOG502R8AX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_6_2_1"/>
    <dbReference type="OrthoDB" id="3773119at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="112" mass="12539" checksum="90D187BEBEAD3A9A" modified="2013-05-01" version="1" fragment="single">PLPEHKSHFHLLCIIRGDFGQHVGCKISTWPIDEAPPYYAISYTTDITLNSSRLEALRNCKYALQQAFATKACKYVWVDAICIDQTAEEKNHQVGIMDQIYSGAKHALACVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSC7</accession>
    <name>M2SSC7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_30499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704455.1">
        <property type="nucleotide sequence ID" value="XM_007706265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSC7"/>
    <dbReference type="STRING" id="665912.M2SSC7"/>
    <dbReference type="GeneID" id="19136253"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_30499"/>
    <dbReference type="eggNOG" id="KOG4008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036234_1_1_1"/>
    <dbReference type="OMA" id="GIHKWIA"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12293">
        <property type="entry name" value="dRRM_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36278" checksum="67B66DD3BD4AC608" modified="2013-05-01" version="1">MSPQPTKTPKPPPKAVADFTVLPLTLSPLPGLPDQCSTAFHYMYIKPHTPSIPTPSSDRSLFIANLPIDASESSLRTLFSEHLGGSMVERVEFDASVPAEPMHKRWKSEGTGAVTMQGKKRKRGDDKEIVAEGVVEDAESALPPLWSNGIRTSGSAGVVVFVDGKSARGAMRGVLRVVKEEGEVVWRGEEGGMGVERYKSHNNLMYPPPSLLQSSLNAYLSQFNALETMRNRLRKTARSIPDEDGFVAVVRGGRVGPARLEEAEKKKAELDERKRNHRATDDFYRFQNRERRKKAEGELKRRFEEDRKRVEGMRERRGKVRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSC8</accession>
    <name>M2SSC8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="13" type="ORF">COCSADRAFT_72854</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704248.1">
        <property type="nucleotide sequence ID" value="XM_007706058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSC8"/>
    <dbReference type="STRING" id="665912.M2SSC8"/>
    <dbReference type="GeneID" id="19140497"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_72854"/>
    <dbReference type="eggNOG" id="KOG3339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064541_0_0_1"/>
    <dbReference type="OMA" id="HTHEMLC"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="260" mass="28395" checksum="95E61D0360D45201" modified="2013-05-01" version="1" fragment="single">MAPPPSTLYTLSFFIATLATLLVAFTLRLLAIIPNASTKTRPLRRKRPLATRVLIVLGSGGHTHEMLCLLRDLDTRKYTHRTYVVSSGDAFSAQRAAQFEQDLQDAARKREKAQEKVVNGQDADESDGKATRPTMQVTDTNGQTRVLDTTRGDDSPACIGPHHYNIAIVPRARKIHQSLLTTPFSALYTLFACFTPLLGAPPPLAGQAPTTPYEVAAADVPDLIITNGPATAVIVILASLILRFFNIKGAESRHKCKTMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSL7</accession>
    <name>M2SSL7_COCSN</name>
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            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_40492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="60" mass="6605" checksum="177D0A62CC8887A7" modified="2013-05-01" version="1">MARGNQRDKAREKNLKEQAGKKSKNTQSGTEFARTKENVAAIMRAKQAAAEAKKAETAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSX2</accession>
    <name>M2SSX2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_175025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704186.1">
        <property type="nucleotide sequence ID" value="XM_007705996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSX2"/>
    <dbReference type="STRING" id="665912.M2SSX2"/>
    <dbReference type="GeneID" id="19132941"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175025"/>
    <dbReference type="eggNOG" id="KOG3190">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048802_0_0_1"/>
    <dbReference type="OMA" id="ERKEMPW"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD59897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="345" mass="39169" checksum="925C2797B0B72257" modified="2013-05-01" version="1">MLAMVLANKLDRNLRAVEESSDGEDYYEVTDRSSSASVIEADEGGNVISSGGEEDAGSEDRSDVENDDDQVKAQMSRVSFGALAKAQDVLSKSSDRKRKRGDDTSKSQEDKLEALRERLRQIKAEKLASGAQPSKKAKTSSKSKAKPVQSDSGDDDASDSEGSDSDAAPHARSSKHAPAVQSSKRMVSRKRQVVEVKKPVFRDPRFDNVSGPRPDEYVVDKRYSFLNDYRASEISELRNTIKKTKNEDEKERLKKKLLSMESQQKARENKEKLKEVSREHKKKEKELVKEGKKPFFLKKSEQKKIALVDRFQNMKSKQRDKVIERRRKKVTAKERRNMPDTRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST42</accession>
    <name>M2ST42_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_151745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704435.1">
        <property type="nucleotide sequence ID" value="XM_007706245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2ST42"/>
    <dbReference type="GeneID" id="19131565"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_151745"/>
    <dbReference type="eggNOG" id="ENOG502SMPT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062059_0_0_1"/>
    <dbReference type="OMA" id="YKTECRI"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025307" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37745" checksum="0E254DF9256CC500" modified="2013-05-01" version="1">MRGFISSFLVTVIVAAVTVHAQVKSYIPTEAEYRTECKTCPRSLCPNKLYYSGGDGLNATCWTHGTKIMGDNLWLKTEAGCYITQYDVLEYAGDYTTDLKYCGPASEVQKLTLQDAKLKYKTECRICPELSCDVVSYLNENTELDLTCWYPDGQLIIDDPFWLKTTNNCYVARKNLYSKPDLAKLDDCGPVPFLEILHHNNENGTSDVNKREPTPEPEPELVPAPIPKREADMNVMYLVNVTVGEEYAYCRSCPKESCKIEKTFEFNNEVWLQCLKIVNNLPSEGPTEYWALTTDFCYMNRNDFWEDPAGDFYRFPSCDRFEQGGGSGGDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2STJ0</accession>
    <name>M2STJ0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_125188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703773.1">
        <property type="nucleotide sequence ID" value="XM_007705583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STJ0"/>
    <dbReference type="GeneID" id="19130616"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_125188"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="FKHPTTY"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD60416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="499" mass="55650" checksum="8B6C6D2E75E807B0" modified="2013-05-01" version="1">MSENQDPELAKGDALKVTASASSSKHPVPVEGTTQHLPTYEHEKALTWKLDIRILPMLAVMYLFNALDKGNLGNAKTDGMDKDLHFKGNQYNIMLSIFYVPYVIFAPPVGMLGKKYGPHRVLPIMMFSFGSATLLAASVHNWSGMMALRWFLGMAESAFFPLVIYYLTTFYRRGELARRLAIFYAASNIANAFSGLLAFGVFQIESKLDSWRYLFIIEGSLTVLFSFFAYWYLPKNAYEAKFLNEAEKELAFTRIQIDSSSVVNQEFNLKDALGIFKEPSTYGFLLIEICLGVPLQSVSLFLPQIVGRLGYDKIKTNLYTVAPNVVGACVLLILAFASDYTRLRSPFIALGFLLTFIGFIIYATIDVEHSLTVAYYACFMMTWGTSAPSVLLSTWYNNNVADENRRVTLTSVGVPLANLMGVVSSNIFRPQDAPAYIPALATTAAFGATGCLCAVLLGTYMMIDNKRRNARQGVNLTAKDVSTEKLRDGPKNPEFRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU16</accession>
    <name>M2SU16_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_39940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SU16"/>
    <dbReference type="STRING" id="665912.M2SU16"/>
    <dbReference type="GeneID" id="19139604"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39940"/>
    <dbReference type="eggNOG" id="ENOG502T59P">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="3556572at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="55230" checksum="1FE8C232E1280A80" modified="2013-05-01" version="1">MLYALRSMSRACRYESDALLFHTCKLQDHVYRHASDIEFEEEYGDPDKMHQEDFRLRRATKGLVQCLLDGKSPIAQHVRHLQIGTLRQDVFDSMIAPVLGKVLTRLINLHSLSWDTNIPIPESVLDVLHTTHTTVRLHVTNCLRERKPLDRLLLSSPQLHSLQMNVYFDLVGVCPIVKGSSELQILKRCLMQGNSIKVLHLALENIDKYLYRSAVSDHGIQDWENGPLNFHWQDGDRFPALEEWGWSGSTQYVYSEQQLDMWRRCMDWTQLRVLDFGDHPLISMLPFPSLAGHVPRLNSLAVFITAQKQHDMHEPTRTIPIFEEFLRSIPALEKLRLRWEFIPDCLSMILESQGHSLRELDLYHARSGNAWDQHRYIDILMKAPQLHHLRVRHLLPQGPTVDFQGTWYGHAINSSPSAKYTAMEDVSIEERAQSERKHAAMMERISNRRKALASAAERTPEEIAQVIELARQNPRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUA8</accession>
    <name>M2SUA8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_40266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUA8"/>
    <dbReference type="STRING" id="665912.M2SUA8"/>
    <dbReference type="GeneID" id="19139684"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40266"/>
    <dbReference type="HOGENOM" id="CLU_669036_0_0_1"/>
    <dbReference type="OMA" id="IWECNET"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46756" checksum="23459E0FAE791E5B" modified="2013-05-01" version="1">MKSPLESLPVELFDMIAADFSLPEYRSLRLVSQQLYQFVHEKFARLAFSEQVTTLSPSSLDRLSKVSSHQGLRDAVKTLHIRLLNDEEYANLNAISRVGRFPPPKRFPRVLGVRDNNVNDEAATYAYVLHNERPSRLYDGLLKVLKGLPQLKTIKLSMKPSASYIWECNETPHSLFRSKCFEVVIYAITHSKIKLEEFSMARRKSRNILYKPVDLSFLAFQLAPPSLQALQHCFSNLQSLTLSIMTGYDVPRPDGWTRSICGFIAAAPNLKKLTLSLDRVSAKWPSSSFGGIVVKSLATSCRLPCLETLEVLNCEPHVKDLADLIRTYSSSLQCIVLSHIQLSTDKWCPIEDALKVCHELVYFRLIACEDRWIRLSIKARINGYPDFTWDLYEDHQSASDWLRGVTGLDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SV28</accession>
    <name>M2SV28_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_34710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697485.1">
        <property type="nucleotide sequence ID" value="XM_007699295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SV28"/>
    <dbReference type="STRING" id="665912.M2SV28"/>
    <dbReference type="GeneID" id="19137821"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34710"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="OMA" id="KMYIEEG"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="231"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD66125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="34208" checksum="9EB3500027B49DAD" modified="2013-05-01" version="1">MATSPPPTSTGSSKLDAAKAAIGAKVDPTAPTGVGLYARFAFAGAVCCSVTHGALTPVDVVKTRIQLDPATYNTGLIGGFRKVIANEGAGAVWTGFGPTAAGYFLQGAFKFGGYEFFKQQAINMVGYETASNNRTAVYLASAAVAEFFADVALCPLEATRIRLVGDPTFANGLVGGFSKILKNEGVGAFYSGFGPILFKQVPYTMAKFVVFEKVNEAIYTVVDKSKTSSSMQTVYNLSSGLMAGFAAAIISQPADTMLSRINKTKGMPGEGTTSRLIKIAKELGVRGSFGGIGARLFMVGTLTAGQFAIYGDIKKALNAVGGVEIAKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SV74</accession>
    <name>M2SV74_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_237820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703325.1">
        <property type="nucleotide sequence ID" value="XM_007705135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SV74"/>
    <dbReference type="GeneID" id="19134917"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_237820"/>
    <dbReference type="HOGENOM" id="CLU_1855103_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="138" mass="15751" checksum="73EDCA39147A7E92" modified="2013-05-01" version="1">MAILIIIIIIIIIIIIIIIIITAVIFQYIRRRINWACRMKMRCIVCNVGVGSAPRHATPRPQHVPFTFLVWSAAAGEKHAGAAAVSSRLPPHTPSHRKQPRHQRRGHRHMLNNFHGTVATLPLLLVFLYLNHLYHLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVX8</accession>
    <name>M2SVX8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">COCSADRAFT_39846</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Vacuole membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703120.1">
        <property type="nucleotide sequence ID" value="XM_007704930.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SVX8"/>
    <dbReference type="GeneID" id="19139580"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39846"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_7_1_1"/>
    <dbReference type="OMA" id="MRQHSAK"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000446">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
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    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
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        <property type="entry name" value="FRB_sf"/>
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        <property type="entry name" value="HEAT_ATR"/>
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    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
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        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
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    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
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        <property type="entry name" value="PI3/4_kinase_CS"/>
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    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
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    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
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    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAT"/>
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        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rapamycin_bind"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="HEAT" evidence="18">
        <location>
            <begin position="704"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="21">
        <location>
            <begin position="1243"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="20">
        <location>
            <begin position="2022"/>
            <end position="2340"/>
        </location>
    </feature>
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        <location>
            <begin position="2383"/>
            <end position="2415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2321"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="2324"/>
            <end position="2334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD61151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2415" mass="273439" checksum="022DF5B5CBE2E882" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXG1</accession>
    <name>M2SXG1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenolic acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_33910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007698303.1"/>
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    <dbReference type="eggNOG" id="ENOG502QRS2">
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    </dbReference>
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    <dbReference type="OMA" id="RYELWCF"/>
    <dbReference type="OrthoDB" id="4415004at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Calycin"/>
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        <property type="entry name" value="PA_de_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087:SF1">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05870">
        <property type="entry name" value="PA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20925" checksum="F8B04AC5F983A0F2" modified="2013-05-01" version="1">MAPGDNLPDFHTNTPLDPTFEKDILDTHLIYDYDAQDSNGKPEKWRYEMWFFSSDRIVYAVHGGPMAGRRNYQRATYQCIRPGELWQINWLEETGTVISVVYDIKEKTMTTMIAFSEGHWKRSKEALGDKRNKEDLERWKGLADVGNQMSRFMLSEQGHIVETFKGKGKLVPIKESDPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYM9</accession>
    <name>M2SYM9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_38842"/>
    <dbReference type="eggNOG" id="ENOG502T0TG">
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    <dbReference type="HOGENOM" id="CLU_199238_0_0_1"/>
    <dbReference type="OMA" id="RHHQLIK"/>
    <dbReference type="OrthoDB" id="5402816at2759"/>
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    </dbReference>
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            <end position="51"/>
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        <source>
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        <source>
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    <sequence length="63" mass="6955" checksum="3449595DED899277" modified="2013-05-01" version="1">MAAISMPLAARAEYTLHQLAKRDNWAQREPGVIVVLCIVFLVAILFIAMFINKKRQASKGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the stealth family.</text>
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        <property type="protein sequence ID" value="EMD67430.1"/>
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    <dbReference type="OrthoDB" id="263283at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Stealth_CR2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="437"/>
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            <end position="127"/>
        </location>
    </feature>
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            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD67430.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007698946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYU3"/>
    <dbReference type="STRING" id="665912.M2SYU3"/>
    <dbReference type="GeneID" id="19131859"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157866"/>
    <dbReference type="eggNOG" id="ENOG502S3SU">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_040397_0_1_1"/>
    <dbReference type="OMA" id="SIQWHHP"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
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    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
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    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="53"/>
            <end position="74"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="52"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="334" mass="36525" checksum="27A7B6FE0DEE030C" modified="2013-05-01" version="1">MATKMLSRARDWDFDIDRYLNRVVVPSPLHRLPAPVSRFLGYRKETRQDVGNVLGAFWSLVGAFCGLAVVAGVFNNTGSIQWHHPPALIASFGASAILEYNSIRSPLGQPRNAILGHAISALIGVSISKLFQYHSDYETIKWIAGATACGCASAVMLLTNTVHPPGGASAVLAATDPIITAMGYYFVGLVLWGTTLMVIVGLIINNIQRQFPAYWWTPLDVRKAKVEDEEVVPDAKGGIERKKTIEEQHYDQDGDRIEINGAEVILPDDMSLNAEETAVLEKLRERLRKKVDSERGGQISEKEDTNSAHASTSSVPDITLLVDTISHHAGHFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZ03</accession>
    <name>M2SZ03_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_34328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696593.1">
        <property type="nucleotide sequence ID" value="XM_007698403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZ03"/>
    <dbReference type="GeneID" id="19137593"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34328"/>
    <dbReference type="HOGENOM" id="CLU_933795_0_0_1"/>
    <dbReference type="OMA" id="GVCSWPY"/>
    <dbReference type="OrthoDB" id="3677304at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34731" checksum="5FF93F4C577FE206" modified="2013-05-01" version="1" fragment="single">MQPALASRLMALPPELRCHIYSFLPELVYKYIWPVFKSSPAGVCSWPYYRLPTSLLLISKLIYQETRDASVQKRLCDLNEQYPPVVVLGPANSMYKPRNGFMDELFGLLSRHNGNTSSLYDVSNTLAERTPKRICHDIRAWTNRSLEARLRVHWEQVYQRFPRELGYSEENLETFVTCTLTRMAHNNAKEARIRLLIRGSAFNNAWLWERRMMEYLLQYKTRALLTFHCDAESMHSSEAVTIVLPPQPHGSYVDNFIARMLEENFGFELEAPSIQDERLFSEHGHYSIHHGNEKADTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZ18</accession>
    <name>M2SZ18_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_34345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696596.1">
        <property type="nucleotide sequence ID" value="XM_007698406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZ18"/>
    <dbReference type="STRING" id="665912.M2SZ18"/>
    <dbReference type="GeneID" id="19137602"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34345"/>
    <dbReference type="eggNOG" id="KOG2928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018596_2_0_1"/>
    <dbReference type="OMA" id="AHERYFF"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="246"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="513"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD67555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="584" mass="65656" checksum="B2640D11FF92EA0D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2T071</accession>
    <name>M2T071_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_267166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695705.1">
        <property type="nucleotide sequence ID" value="XM_007697515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T071"/>
    <dbReference type="STRING" id="665912.M2T071"/>
    <dbReference type="GeneID" id="19135547"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_267166"/>
    <dbReference type="eggNOG" id="ENOG502SKZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024203_0_0_1"/>
    <dbReference type="OMA" id="FGEAMHW"/>
    <dbReference type="OrthoDB" id="5413829at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2790">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="347" mass="37391" checksum="808A7107C9A6731B" modified="2013-05-01" version="1">MAVSHEKPGTAAAKSTHVSDPALDPFLQSQFDPADYLNATLPSLSLSSRSKTGNAASLADLSSQTQDLLSQLNAHTTRLSAILTQLADDILRTGGRLAYEVEVLRGEAVSLTETLTDGLKNDVEKFLPGGLTLKADPVEGEPGSPAPAQTEAPSEALPALPALVEPEETTPEYISDLHTLTTVRSRLENVIKVFGEAMHWTIPPSEVSLGASLISVSAPEPGTDSASREQKGKEFATSLRSEIADLITGDPEGGMHKAEVRIQALRDLAQVWKGTAEEKARTKFIDGLVKLAEDKQRELDKEKDKNKDRGQQKPVRSSSTSKSQPQPPQQRTGGFLENLQRIRGFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T183</accession>
    <name>M2T183_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_92883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701256.1">
        <property type="nucleotide sequence ID" value="XM_007703066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T183"/>
    <dbReference type="STRING" id="665912.M2T183"/>
    <dbReference type="GeneID" id="19141474"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92883"/>
    <dbReference type="eggNOG" id="ENOG502QWD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032662_0_0_1"/>
    <dbReference type="OMA" id="VFCLTHD"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47017" checksum="D39844CD1C3F7AFC" modified="2013-05-01" version="1">MARFTPLLETEQAPTTSMKPQRISSHVTLQAPLSRRGRGPGLVLVLDHYAEIGPSEKYLDPPPLQKWAEEGFAVVQVCCNEAEDGGEFPLQKALDALKTCDGCEFDKGVGLISYISRTPYYVEEAACQNPAIKALISYGGRKFISLSSTNQPPQLIHASGPPLAHRRQSSSESVGISPSSVKTYRYEDAEKESGWILPSDPKYHKRNAGIAHTRSLTFLKPLLGGPYFDLEAVWEEHTKYEFGERDVAKTMATMVDQPYVNHIPTMTGGIGKTNLTSFYTHHFIFSNPPDTSLSLISRTVGIDRVIDEFIFTLTHTSTVPWLLPGIPPTGKRLAIPFTSVVALRGDRLCHEHISWDHASLLKQCGLLPDYVRFPYEIEGETVPEGKRVEVRLPVVGEEGSRKLADEGAEVSNALMGGTWRVVEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T217</accession>
    <name>M2T217_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_37932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701033.1">
        <property type="nucleotide sequence ID" value="XM_007702843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T217"/>
    <dbReference type="STRING" id="665912.M2T217"/>
    <dbReference type="GeneID" id="19139127"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37932"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047858_0_2_1"/>
    <dbReference type="OMA" id="ANCPEHQ"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="254"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD63057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="350" mass="39275" checksum="34AA003B748AB1C9" modified="2013-05-01" version="1">MNGIKADPDVKMDPDASTPGGGFMDDEFYEDTGEMIMSKDSSDKDIWLTRIPPWLYEAVSKWDDLADGNDNDQIQIGEVYGFATTSGIDKTKPMRVFLNDRWRAKSNLPSAFQLDPAPATDTILGNTYVFTEKDLPGFRGHGYSRGGNQGSFGGVQDPKARVQKRSKYKKAIPKQTALVGHATRQYNANPLETKEYKDFSAARIKQAIQGSHMTTIITKDTEVSDVNNSIMLNNRFKNFIRPMTKGKSQQNKAARMARSDLIDFLHTLFDEYQYWPMKAIKQRTKQPEQYLKEVLGDIALLVKSGPFASNWKRQAVFENQRDTSKQAEAAAPEGPGDGDSEGEDEMEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2F2</accession>
    <name>M2T2F2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal targeting signal receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_359420</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701413.1">
        <property type="nucleotide sequence ID" value="XM_007703223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2F2"/>
    <dbReference type="STRING" id="665912.M2T2F2"/>
    <dbReference type="GeneID" id="19138619"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_359420"/>
    <dbReference type="eggNOG" id="KOG1125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013516_3_0_1"/>
    <dbReference type="OMA" id="WEEQFKQ"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000218">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD63192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="641" mass="70774" checksum="21E25298D6FA8DAD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2H9</accession>
    <name>M2T2H9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">COCSADRAFT_134693</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696220.1">
        <property type="nucleotide sequence ID" value="XM_007698030.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2T2H9"/>
    <dbReference type="GeneID" id="19130939"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134693"/>
    <dbReference type="eggNOG" id="KOG1798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000556_0_1_1"/>
    <dbReference type="OMA" id="MLDQCRY"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000015">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1523"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMD68680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2235" mass="254613" checksum="D0903AE65C501FAB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2W2</accession>
    <name>M2T2W2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_37155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700352.1">
        <property type="nucleotide sequence ID" value="XM_007702162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2W2"/>
    <dbReference type="GeneID" id="19138912"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37155"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559019_0_0_1"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="9"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="6">
        <location>
            <begin position="347"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="579" mass="64761" checksum="B3C7780F42E9A2DE" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2Z8</accession>
    <name>M2T2Z8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_37201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700363.1">
        <property type="nucleotide sequence ID" value="XM_007702173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2Z8"/>
    <dbReference type="STRING" id="665912.M2T2Z8"/>
    <dbReference type="GeneID" id="19138923"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37201"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OMA" id="YKHMVGH"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="444" mass="48085" checksum="C6F3F23F09D60F99" modified="2013-05-01" version="1">MAEQTRIAIVGAGMGGLAAALALAKAGHKNITIYENAPVMGFVGAGIQLAPNMARILDRLGCWGPIRDEAVVCANTSIKEGSTDKELGFVDLGYVKEKYGYPHMVGHRASLANGLFEGCKKESGITFKLGCTLSDFRFGSKPKFTVTPSQGSLEPYQVECDILLGADGVKSSTRVAMLKELGHTGAARDSGQAAYRIMLNRSQMEHDPELLKLIDSDTVTRWIGEKKHIIAYPIHNKQIYNISTAQPDTNFAGAPDAQYTTRGSKKAMLDVYGDFCPMIHRMLNLVPEGEVVEWKLRVHDPLTTWVHGPTALVGDACHPTLPHMAQGAAQAIEDGAVLGVVLSPKRIADGRPETIERALRLYEKLRKPRAEALVELAAESGRQMHLGAGKAKEERDKAFAALKEGKGKVPDRWADADVQANVYGVDVVAQAEELCDKEGFGPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T319</accession>
    <name>M2T319_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_181715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700558.1">
        <property type="nucleotide sequence ID" value="XM_007702368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T319"/>
    <dbReference type="GeneID" id="19133315"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_181715"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OMA" id="FHSTEFA"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD63442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="326" mass="36256" checksum="5649D588D10BA5E5" modified="2013-05-01" version="1">MVFKKLRVKLGNQLSQVFPPAPTFTEDSLPDLKDKVFLVTGASTGVGKELARLLYSRNDTIYAAARSLDKTTAALEWIKEQHPSSKGKLSHVHLDLNDLEGIKPSVEKFLAQESRLDVLINNAGVMMTPQGSTTKQGYEQQLGTNCVAPFLFTKLLTPLLIVTAKKEPAESVRVVWVSSSLADVAAPKGGVDMQNLDYKKNAGPTTKYSISKGGNILQALEFQRRYGAEGVVSVPLNPGNLRTELTRHIPAWQKMIIKFILHPPVNGAYTELFASLAPEAAKLKESEWVVPFGRVMPLRKDYWGQEGKETAKAFWEWNEQQVERYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5R9</accession>
    <name>M2T5R9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_89921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700307.1">
        <property type="nucleotide sequence ID" value="XM_007702117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5R9"/>
    <dbReference type="GeneID" id="19141323"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89921"/>
    <dbReference type="eggNOG" id="ENOG502RCWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097615_0_0_1"/>
    <dbReference type="OMA" id="GFEFADH"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="2">
        <location>
            <begin position="30"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="217" mass="24027" checksum="E22085C096335493" modified="2013-05-01" version="1">MSSIHGLSTKLTPIYPSSSSATPEESPATQSLISSLNLQKHIEGGYFAELDRNPLLIPNPFLQSDNGEEEVKRTAQKPLSGDDAVRNASTSIYYMLSRGEPQGNFHRNKGRTIHTLISGRGRYVLIHADEPGTPKRVESFVVGMDFAAGEKSVWVVEGGKYKASFLLEGAEGERLLISETVIPGFEYSDHDFLTLEGFRKIVTPEQAEELEWLVRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5Z8</accession>
    <name>M2T5Z8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_355752</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699244.1">
        <property type="nucleotide sequence ID" value="XM_007701054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5Z8"/>
    <dbReference type="STRING" id="665912.M2T5Z8"/>
    <dbReference type="GeneID" id="19138392"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355752"/>
    <dbReference type="eggNOG" id="KOG0276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005507_1_0_1"/>
    <dbReference type="OMA" id="YVDYYPQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="316"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="590"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="780"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="820"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD64626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="860" mass="96199" checksum="8448425A851D0AA5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6E1</accession>
    <name>M2T6E1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_32625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694345.1">
        <property type="nucleotide sequence ID" value="XM_007696155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6E1"/>
    <dbReference type="STRING" id="665912.M2T6E1"/>
    <dbReference type="GeneID" id="19136848"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32625"/>
    <dbReference type="eggNOG" id="ENOG502S739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152700_1_0_1"/>
    <dbReference type="OMA" id="TIDYQMH"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="101" mass="11272" checksum="6703416758F32FB1" modified="2013-05-01" version="1">MSFITKRGLSTLIPPKIASPNAIGSSPNAVRMQKVVNFYEKLPRGPAPEPEAKGLLGRYAKKHMGKNPSGRPLVHVIGFLIALGYAQNYYFHLRHHKNNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6M0</accession>
    <name>M2T6M0_COCSN</name>
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        <recommendedName>
            <fullName evidence="16">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_88462</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="16"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699438.1">
        <property type="nucleotide sequence ID" value="XM_007701248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6M0"/>
    <dbReference type="STRING" id="665912.M2T6M0"/>
    <dbReference type="GeneID" id="19141247"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_88462"/>
    <dbReference type="eggNOG" id="KOG0289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023894_0_1_1"/>
    <dbReference type="OMA" id="SLDQHWA"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="17">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD64896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="471" mass="50034" checksum="57F3426A35D8A612" modified="2013-05-01" version="1">MLCAISGEAPREPVASRKSGNVFEKRLIEAHIAEHHTDPVTGEDLATEDLIELKSPNVVTPRAPNFTSIPAMLSAFQNEWDALVLETHTLKQHLAQTRQELSTALYQNDAATRVIARITKERDEAREALSNVTISGGAQGDAMQVDNQGLPQDLIEVVDDTQQELFGSRRKRAVPAGWATGEVITNYDLVKTTEAIYPGSSNIAVQEDGLVLFGGSDGTAGIYALAEGRVTQTFNAGSAITAAAWCGGRAVVGTSAGVAKIFEQGNEVAQVGSHAGAITSISVHPSGKMLATAGADKHYAVHELTSFKTVSQVYIEAEITCVAFHVDGMLFFVGSSDGNIRIYDIKTGVAMAQLETGAPIVDLKFAENGTWFAVAQQGSTTVSVWDIRKQTVIYTLESGSLVTCCEWDYSGMYLAIGGTGSVSVQQFTKATKSWAELVRKALPVKDVAWSGKAESVVALTPEGGLAVLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7Y8</accession>
    <name>M2T7Y8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_86667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698529.1">
        <property type="nucleotide sequence ID" value="XM_007700339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7Y8"/>
    <dbReference type="STRING" id="665912.M2T7Y8"/>
    <dbReference type="GeneID" id="19141130"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86667"/>
    <dbReference type="eggNOG" id="KOG3059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024002_2_0_1"/>
    <dbReference type="OMA" id="STSYHAF"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD65356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36205" checksum="55C62162C456CF8F" modified="2013-05-01" version="1">MSSRQPKGHYKKLLWFKQPFPDNYTDEATFLDHLQRNPRLQPYEFWSLMSDATVIVQHLASVIIFCCCFVAIIHGRVSPVAVVGWASMCTVLAWVLWDHWMGQEFKTVANVPLTPTLETDEVVPQASQTLSPRAKQRLATAKSAILIYAALLGLSPILKSLTRSTTSDSIWAISAWLLMMNVAFFDYSAGTDAQLPASISTNSAMMASAVLASRLPSTTHVFSLTLFSIEVFGLFPIFRRQLRARSPWGHLTLTITLITCAWGSLFVTLTGNGSATFIAGAILGGILTFLSMGVCSWWLIGLQKYKNEIHGPWDPARPIIRRHWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T931</accession>
    <name>M2T931_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_305619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698588.1">
        <property type="nucleotide sequence ID" value="XM_007700398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T931"/>
    <dbReference type="GeneID" id="19136265"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_305619"/>
    <dbReference type="HOGENOM" id="CLU_033666_7_0_1"/>
    <dbReference type="OMA" id="RREKTCA"/>
    <dbReference type="OrthoDB" id="4156902at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="149" mass="16465" checksum="CEAF15FF982E9B84" modified="2013-05-01" version="1">MAPNYNIATRALVVTLKSVAGKSNSKVCYLTGLPESTIRSIYAKAIKRGFKYNASQPITICNAHLEDAPRSGRPTKETEAVRQSITQKLVRDRYGREKSCADLAGELSQEGVNISATTVRQILKKAGYKKTKPTRKPGLTKKIREERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T935</accession>
    <name>M2T935_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_140099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ND90Pr</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T935"/>
    <dbReference type="GeneID" id="19131147"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_140099"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023630_0_0_1"/>
    <dbReference type="OMA" id="GHHWDSY"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026334" evidence="6">
        <location>
            <begin position="20"/>
            <end position="531"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD65761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="531" mass="59656" checksum="9FF772E824C7AEB8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name type="common">Common root rot and spot blotch fungus</name>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T994"/>
    <dbReference type="GeneID" id="19138344"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355197"/>
    <dbReference type="HOGENOM" id="CLU_1732609_0_0_1"/>
    <dbReference type="OrthoDB" id="3662064at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="154" mass="17748" checksum="426C600F0C2DC43F" modified="2013-05-01" version="1">MVSNDQNPSLSEQLALFPPLSAMVAMESSTTFNTQLPPIPEGGWDFNWKEDTFPPLNLHEDFEQTTTATNDNSLPETHEELTKLQDEVRQLRHDISELNEMVYNRLDDIEKRLSANNRYVGGSLVPWLMEVHDKYSQMLARVTKQEEQTVNRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2TA45</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_56948</name>
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    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TA45"/>
    <dbReference type="GeneID" id="19140334"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_56948"/>
    <dbReference type="HOGENOM" id="CLU_1769071_0_0_1"/>
    <dbReference type="OrthoDB" id="3686806at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="122" mass="13478" checksum="02A6BE05AD984C14" modified="2013-05-01" version="1" fragment="single">VEAALQTISQAPIESLLVNTHQLCEANSAIAKAICYLSSRLYEETGQFKPQFNDTGNCASTQVEPPPISEVNTTQGSDQVTLHQYGSRHDLPEHAIVRLAQYWVKKRLAGTSLLNIVDENRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBA9</accession>
    <name>M2TBA9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_169117</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_169117"/>
    <dbReference type="eggNOG" id="ENOG502S2DA">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025837" evidence="1">
        <location>
            <begin position="17"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="273" mass="28163" checksum="1049A1DC8ED2FB74" modified="2013-05-01" version="1">MTLKYLSLALAAVAAASPFEGFQKDDEASYKACKPNGATTETPPSVGPGLSSLYTNVVASVQGISFEPRSINERAEGFACHPSLDCVNLQNLNIPMCYDKFTTNFQFPDGSYGTIATGDYHSGGTDVNLISGNYTKDGQSANIYSGNEAERPNTSTMSIPPQFTGTGVGGAIPVSQLGSIVVFTTTLPPVTYTAPTTVAESVATATVGGQQIETTIPATTITQATTIAGRTAVVTETRTDAQPTKTGGAGHVGVDGTASFGMSFLGALMYALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
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    <name>M2TCH8_COCSN</name>
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            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_33837</name>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698283.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19137332"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33837"/>
    <dbReference type="eggNOG" id="ENOG502QQGR">
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    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Diverse_Enzym_Activities"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="30"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="443" mass="48387" checksum="EA1FA502D2265234" modified="2013-05-01" version="1">MGLPTITQETAAALKKHIDNAIQPTAVNLPLPSALVHVVDAQNNVLFSHGSSPSKPPTSESIAIIQSLTKIIGAIAYMQLVEQSLATLDDSTTISTFLPELTSKRVLTGYTVDTKTGKKQWQLEEQKSDITARMLLNHTYGGGHTYFNQLLLDYVRDLGEGTWEKANEANNPYGILLASPLLWQPGTHTNYGQGLDWIAVLIERITKKPLGDYLQENIFNPLGLREIGFEPAFGGSATALPENAGKFWPRNMRTENGFIALDAAEPEVIRRLDAYPEGQHHVGCLGTGLVASARDYTHLVAALLPQNQGVDPITGHRILSAESVAEISKPQLAEHLRNDSRSLPVSDALPILLPVDLSSPHLDPEGSYGLGCGVQGAQRVLRDGKRGRSKGTVYWYGAPNCDMWIDREKGVVVTVWGSYYPWNEGAWVDFVGEVEGLVYEGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2TE46</accession>
    <name>M2TE46_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional repressor Tup1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_179158</name>
    </gene>
    <organism evidence="9 10">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TE46"/>
    <dbReference type="SMR" id="M2TE46"/>
    <dbReference type="STRING" id="665912.M2TE46"/>
    <dbReference type="GeneID" id="19133183"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_179158"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="OMA" id="LTPDANW"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
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    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="513"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="555"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD67511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="594" mass="64413" checksum="DED40918B39EB020" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEU1</accession>
    <name>M2TEU1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_168483</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696964.1">
        <property type="nucleotide sequence ID" value="XM_007698774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEU1"/>
    <dbReference type="STRING" id="665912.M2TEU1"/>
    <dbReference type="GeneID" id="19132580"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_168483"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061883_0_0_1"/>
    <dbReference type="OMA" id="EHDPYRF"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD67262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="242" mass="27426" checksum="8B0268A6102CDB66" modified="2013-05-01" version="1">MAALNGEDPFLQVQADVLTALDNARPLFKSYLRIRSSASSANSPELREARSELEQTLQDLSQDLEDMVESVKVVEHDPYRFGLEIDEVERRRTLVRDVGYEIENMREELQQTVQQAKNKGKSTANGDVLPDPDTFEDEDNYAAFEQERQMELMHEQDEALDGVFRTVGNLRQQADDMGRELEEQGELLADVDNVADRVGGKLQTGLQKVGHIIRKNEDSWSSCCIGVLIFVLILLLVLLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF30</accession>
    <name>M2TF30_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_83243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697395.1">
        <property type="nucleotide sequence ID" value="XM_007699205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TF30"/>
    <dbReference type="STRING" id="665912.M2TF30"/>
    <dbReference type="GeneID" id="19140944"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_83243"/>
    <dbReference type="eggNOG" id="KOG2708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_1"/>
    <dbReference type="OMA" id="HHRSWVV"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD67846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="353" mass="38362" checksum="8246C9CDF0B08F02" modified="2013-05-01" version="1">MIAIGLEGSANKIGIGIISHPGPNKPPIILANLRHTYNSPPGEGFLPKDTAIHHRTWVVRLIKQAVRQAGVNIEDIDCICYTKGPGMGAPLQSVALAARTISLLWNKPMVGVNHCVGHIEMGRSITRADNPVVLYVSGGNTQVIAYSAQRYRIFGETLDIAIGNCIDRFARTLMIPNDPFPGYNVEQLAKKGKNLVDLPYGVKGMDASFSGILAAADLLARGLDESLPDEKRLKTEDGELVTKADMCFSLQETIFAMLVEITERAMAHVGSQQVLVVGGVGSNLRLQQMMGMMARDRGGNVFATDEMFCIDNGIMIAHAGLLEYGTGVITKLSDTTCTQRFRTDEVYVGWRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGE0</accession>
    <name>M2TGE0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_33251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695493.1">
        <property type="nucleotide sequence ID" value="XM_007697303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGE0"/>
    <dbReference type="STRING" id="665912.M2TGE0"/>
    <dbReference type="GeneID" id="19137107"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33251"/>
    <dbReference type="eggNOG" id="KOG1594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048345_2_0_1"/>
    <dbReference type="OMA" id="TQALHSY"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD68311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="320" mass="35070" checksum="A69A6867509BA459" modified="2013-05-01" version="1">MVERANRPSALNAPAATGPSPQVDIVGEAGSQKVVARLPSGESVEVLLYGATVTSWKSNGGQTENLWLSEAADLTGKKPVRGGIPVVFPVFGPPPKEGHPTSTLPQHGFARGSRWEFMGKSTAEDALDSNSVKLDFGLDRQALSEESRKAWPLDFGLVYSVTLSKDSLQAVLTVRNEGEESFEFQFLLHTYFKIQDISKVVITGLAGTEYIDKVLNASIHTQSDNQLKITGEVDRVYKDIKQDTTSIVEDGKPRFDVIRDNVKDTVTWNPWVEKAKAMGDFSPDDGYKNMVCVEVGAVDGWQKLEKGEVWEGGMLLKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGS1</accession>
    <name>M2TGS1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_167196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695678.1">
        <property type="nucleotide sequence ID" value="XM_007697488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGS1"/>
    <dbReference type="STRING" id="665912.M2TGS1"/>
    <dbReference type="GeneID" id="19132498"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167196"/>
    <dbReference type="eggNOG" id="ENOG502SC62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098671_1_0_1"/>
    <dbReference type="OMA" id="GVWRTTH"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="193" mass="21994" checksum="ED0CE177EA3715CD" modified="2013-05-01" version="1">MSQSPATRPVPTPTPCWQIQPVTHTTTPQVVRFIKEARREMFPQLCAQRDDEVARWIQSGCFLFATNESAHTQSESKDQDEKEIIATIGFVPYHHRFTHFPPYSDARRTVEVVRLFVLPPFRRCGLASALVCALKRRAVQDGVGRLYLHTHPFLPGAIAFWEKHGFGIMCVEEEDGVWRTTHMEMLVGEDGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2THU5</accession>
    <name>M2THU5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_80467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695936.1">
        <property type="nucleotide sequence ID" value="XM_007697746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THU5"/>
    <dbReference type="GeneID" id="19140790"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80467"/>
    <dbReference type="eggNOG" id="ENOG502SSIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1366027_0_0_1"/>
    <dbReference type="OMA" id="NWCPSSA"/>
    <dbReference type="OrthoDB" id="2426396at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF1">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026472" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="200" mass="21005" checksum="B771D3A616AFDCF8" modified="2013-05-01" version="1">MRFLTPWSLFLSSLTVCTAEPIAKPEAMPQQYTNNAPFSGAVYIVNPEGQQVVAQDQNWCPSSASVSCSNVDHPSWCCPSNYQCAVPANSNGLIGCCPNGNQCGGVVNVAQVTTVTVYPQQQTVYAVPPQTTVYHQPDPAQGGFCATITMNGPDLPRAEQGSCGTILIVAGAPSLKVLSAGAGIVAFFMHFALGRMFNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIA7</accession>
    <name>M2TIA7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_178268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696048.1">
        <property type="nucleotide sequence ID" value="XM_007697858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIA7"/>
    <dbReference type="STRING" id="665912.M2TIA7"/>
    <dbReference type="GeneID" id="19133129"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_178268"/>
    <dbReference type="HOGENOM" id="CLU_070614_1_1_1"/>
    <dbReference type="OMA" id="PTIHEYD"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="1">
        <location>
            <begin position="9"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="299" mass="33310" checksum="2635E5C6AD61BE18" modified="2013-05-01" version="1">MAPSIAYPGLYAEVTVDGCRLTEYDDGEDARSKTKTVYIQSEAGEQFGVQYFIPPNLFKEYGIKAEVSIDGVSMRKYIHDTYVGRLHGVSRYACASSAHVGNLFIGQRFRFATLDTHDETEPVNTAVQNQLAATGDISVSFYRITNVRVSSAGKKAPTIHEYDKVPEKALKGSAVSLKTQLDPFERIAPVTWVEADHVDGDRPFAIIQFRYRSAAALRSLHILPPLQNSVSLEKGSASKLSMAKKARPLDDYHPGKEVMPVMKRQRAENDEDSEVKLVVERSAKRRCLPTNKDEIVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ74</accession>
    <name>M2TJ74_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_134859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696277.1">
        <property type="nucleotide sequence ID" value="XM_007698087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ74"/>
    <dbReference type="GeneID" id="19130944"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134859"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_0_1"/>
    <dbReference type="OMA" id="NIYFRQP"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05323">
        <property type="entry name" value="ADH_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31534" checksum="9C91B8241FD2C819" modified="2013-05-01" version="1">MSKPVAIVTGAGSGIGEATATHLYSLGYKVVIADLNPTSGQRVTSALGKDALFHQTDVSSYKSQAQLFKRAYEWGGNRLDFCHANAGIDDRQNVHESMDKEEVDEEGLVKKLNTKTIDVNLEAVIQGLWLFKYYVRRSKEAGGGKGYFVATSSAAGLYFMPQCPQYTASKYGVIGFVRASAPNFINENITVNAICPAFIPTNLCPPEVAARWPKEHITPFSTVLKAIDAFLNDDKLTGQAVELSQENIYFRQPVDYANESQQWIGLESDKIWNEGYKEPPKRNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ82</accession>
    <name>M2TJ82_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_109659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696287.1">
        <property type="nucleotide sequence ID" value="XM_007698097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ82"/>
    <dbReference type="STRING" id="665912.M2TJ82"/>
    <dbReference type="GeneID" id="19130097"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_109659"/>
    <dbReference type="eggNOG" id="ENOG502S4G4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070360_0_0_1"/>
    <dbReference type="OMA" id="EGLWHLD"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="35"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="335" mass="38552" checksum="97CA145D16371656" modified="2013-05-01" version="1">MLDVEDFDAVYRGLNYNEGLVQEIQSYRTALGGRTYFERLLVLLQIKGSKLYPPKSPQQLQDLHQRIVSAETTLHNKHCLVFYLLKDLSPQHHDTTELSEAFAKEVHLEKRFWTFVEGLWFLDHLQFSTAVGHLTHPSIIPTFPDEIMHTLLTGGDKLSSLGMGGGPKDDVLALAYYNCVKPPLEDEKTRVEFAKYLAGRNVTDMYDWIHNRPEFEQKPLLEILIEETLDHNAWADRSEHDVYTRDAKAYELVSLPFSEEEEEFIERFLTEGRGRTFPNAQDLVMMRRISTGKLADVASDVATRGRRLDGVNWDLLKDGVKRGLGPRKDEKDFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK12</accession>
    <name>M2TK12_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_155264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694487.1">
        <property type="nucleotide sequence ID" value="XM_007696297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TK12"/>
    <dbReference type="GeneID" id="19131691"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155264"/>
    <dbReference type="HOGENOM" id="CLU_177927_0_0_1"/>
    <dbReference type="OrthoDB" id="3795508at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="83" mass="9194" checksum="CE4BBEC6675403BE" modified="2013-05-01" version="1">MPLRCPAGALPEAYRLICLRSVRAFARGQKEKCSPVPEYVEAEFAVFLAAMDLVAAARHGDEPEDDWYAAKQRLESAALDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKI0</accession>
    <name>M2TKI0_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">Histidine kinase group protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_131691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694924.1">
        <property type="nucleotide sequence ID" value="XM_007696734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKI0"/>
    <dbReference type="STRING" id="665912.M2TKI0"/>
    <dbReference type="GeneID" id="19130827"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_131691"/>
    <dbReference type="eggNOG" id="ENOG502QUMF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012587_0_0_1"/>
    <dbReference type="OMA" id="WLQMPIE"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="91921" checksum="85A6F9ABBBCA3DB7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2QS92</accession>
    <name>M2QS92_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_104830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445756">
        <property type="protein sequence ID" value="EMD58074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007708035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QS92"/>
    <dbReference type="GeneID" id="19129950"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104830"/>
    <dbReference type="HOGENOM" id="CLU_3129696_0_0_1"/>
    <dbReference type="OrthoDB" id="5410741at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="50" mass="5720" checksum="74F7DBADB8FBB9CB" modified="2013-05-01" version="1" fragment="single">PHPPYSPDLNLIENVWSLLKDRLSKRPFGSLGLDINKESINSFIKAIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSP3</accession>
    <name>M2QSP3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_351437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445665">
        <property type="protein sequence ID" value="EMD58199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706100.1">
        <property type="nucleotide sequence ID" value="XM_007707910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSP3"/>
    <dbReference type="GeneID" id="19138090"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_351437"/>
    <dbReference type="HOGENOM" id="CLU_151056_0_0_1"/>
    <dbReference type="OrthoDB" id="3693743at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="115" mass="13291" checksum="59A3F991C0A9922F" modified="2013-05-01" version="1">MGFTASHRRLRCGPHTLNLVSQAFLWGNNAAAYDNTDENLQDGDRLLQQWCRDGPLCILIAIINHIKTPQQQELFESFQRLADQELPIHEQKILQPVEPVVTRWNSYFSAFERAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSY6</accession>
    <name>M2QSY6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_280969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445658">
        <property type="protein sequence ID" value="EMD58289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706043.1">
        <property type="nucleotide sequence ID" value="XM_007707853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSY6"/>
    <dbReference type="GeneID" id="19135812"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_280969"/>
    <dbReference type="eggNOG" id="ENOG502SQDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_572620_0_0_1"/>
    <dbReference type="OMA" id="WCCNADA"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023717" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="47092" checksum="8E051217385FB029" modified="2013-05-01" version="1">MPSALALRRIAVVTALAACATAQQCYYPNGDKAPDTEQPCSSAEGSACCPEKWQCLDNGLCHYPANNLYGRYSCTDKSWKSEGCPSNLCTYDLKAAGGESITKCSDHNDQWCCNADAVHVNCCQESPSPRPFFALQNPAAYATIGSMTASTAPNLASITGQASGSGSGDQMSASPTSAPQSSSPSSPASSPPTSNTLSSPPSRDSSVSADARSSATPFTSVFFSLSSGSTGFVSVPVTSVLTPTLGTSNAANGGGNEGGSNSNLGLIIGCAVGIPLGLTLIGIVLLLFRKRRQQKSNPYSKADGADEDNSNIAGTAGAKLTKEDMYRNSASAAEIDGNPIGVGRPVSTVQGHAELASGNGFQAGHSTPYRPDAVGIGGGNLHPDRNTWNSVPPRYSPGQSQAPFSHLAASELADTSIRPTVNEKGEQQYVAYKPQPAAEMPTITTPPEDVEKNLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2QTF5</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_103912</name>
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    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705901.1">
        <property type="nucleotide sequence ID" value="XM_007707711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QTF5"/>
    <dbReference type="GeneID" id="19129872"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103912"/>
    <dbReference type="HOGENOM" id="CLU_3147161_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="49" mass="5703" checksum="3EF0079AC34EEE42" modified="2013-05-01" version="1" fragment="single">AGSSYSNRESALKRVREERRCGRYKETGYNARTYKVDIISTSNSDRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2QW99</accession>
    <name>M2QW99_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_257942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705105.1">
        <property type="nucleotide sequence ID" value="XM_007706915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QW99"/>
    <dbReference type="STRING" id="665912.M2QW99"/>
    <dbReference type="GeneID" id="19135369"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_257942"/>
    <dbReference type="eggNOG" id="ENOG502RZ8D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028255_4_0_1"/>
    <dbReference type="OMA" id="NACWGIS"/>
    <dbReference type="OrthoDB" id="10262596at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="entry name" value="Glycerate kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="entry name" value="Glycerate kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00045">
        <property type="entry name" value="glycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="Glycerate kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="28913" checksum="1231495C62FE7BB5" modified="2013-05-01" version="1">MIMSPPLSMEPFAPVGPPAITRRLSQMPPLRSLKTFNLPPEQVDELVHPASAVSQTPTSEILKGHPLRVLVAPSGFKESLGPEQVADAIEAGITKVLDKGSVILRKLPLHDGGEGFAKALVATHNGSIIEETVLGPVGESVESHIGFIGANKETAVLDMAAAAGLRLVPKHLRDPTVTTTFGVGQLMKLALDAGCTKIIIGCGDSGTSDGGAGMLQALGVRLIDVDGDDLPMAGGGRSLSRLASLDWRSIHPRLREDSRKYILQPLNTDRQLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2QXA9</accession>
    <name>M2QXA9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_175547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704695.1">
        <property type="nucleotide sequence ID" value="XM_007706505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QXA9"/>
    <dbReference type="GeneID" id="19132975"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175547"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OMA" id="MNMFSNA"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD59699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="479" mass="54095" checksum="E580E6BE444141D8" modified="2013-05-01" version="1">MANSFIAYLRGDQNAPGERKLVQKLDFFILTFCCLMYFLNYLDRTNLNNAYVSGMREELNFKGNQLNQINTVFTVGYTIGQVPCNIALYYVKPRYFFPLCMVAWGALTMVTAAAQKPQDIMAIRFFQALFESSTFVGTHYILGSWYTEKELGKRSGIFTASGLAGTMIGGFIQTGIHSSMDGLRGMSGWRWLFIIDGIITLPVAIYGYLLFPDTPRNTRAPYLSASEKALAISRVPEVSERTPISLSFVKHCFKTWYWYFFVILWILAGETESFSTNALLQLYMKSHPTNKYTVTQNNNYPTGVPAVGIVSTLFWATLTDFMGGKRYLVGYWIALTGILTSSLILAYPHNTTMHFAMYYWAGSVYACQATFFAWANDVLRYEEDSLRAVVIASMNMGSNAINAWWSIVFYGASYAPYFTRGMWAMIAVSIAMGVWTGLLVWMQVRTEKRREAEGVHGETVVAGKGVEEGEEGEKRENRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2R314</accession>
    <name>M2R314_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_39291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702618.1">
        <property type="nucleotide sequence ID" value="XM_007704428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R314"/>
    <dbReference type="GeneID" id="19139466"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39291"/>
    <dbReference type="HOGENOM" id="CLU_743952_0_0_1"/>
    <dbReference type="OrthoDB" id="5397057at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="372" mass="41462" checksum="F00DF958F1F1568C" modified="2013-05-01" version="1">MATHSSLLSKVPGLLESNEGLFRELKHLDTRRAELEQQLNTHVASLNLVIRCLPEAVDTLLLNEHPASKTSLVTILKNGLLSPLSLQPTEATLSTLENKISEIRIIDNALRSSEQSGKGDAYKAADLASRLAVQSVDCSTILQQISDERSNKDKSLSNVNTRIREATESIERNRILSNQMSTQAGHHDQEASHFDNVGKCTWFIPGINLITIPIALIGSSVHGNKASEYRALQSASESEIKDNESQKVVLEQEMSQLDTALRELSEAISHCSASERQASQFKDQTKILLDQYGRISDHLKQVIKSLDVVESDFISNPLNWDTSRYIVLHSILHMVTTLHEGGFLEEFNHALLRRLKAIEMPGTQTPLMEVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2R424</accession>
    <name>M2R424_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_162487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63639.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R9U4"/>
    <dbReference type="STRING" id="665912.M2R9U4"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_190852"/>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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        <property type="entry name" value="CYSTEINE DESULFURASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="382"/>
        </location>
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            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD63639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="394" mass="43657" checksum="BE587A237C043249" modified="2013-05-01" version="1">MTFDISKARSRFPALQQDQVFLDNAGGSQALDQVIDSISQYLSKTNVQLGASYHTGTQSNTKYEEGYQAAANYINAGRDEIVLGSSTTQLFVNLGSTLQFPAGSEIILSKMEHETNVKAWLFMAERLGLTVKWWASSKEDGLKLTAENLKPLLSDKVKFVACTHVSNILGTIHDVKSIADAVHEVGALFCVDGVSYAPHRAVDVKAFGVDFYAFSWYKVYGPHIAVLYASESGQKAMKPMAHYFNPTKTLEDKIGFAGSNYECVQSIPQITSYLSGAFPAITEHEGKLQTILLDFLNSRPDITVLGSTSTDSEIRVPTISFVVKGMNSKQVVDEAEKISNYGFRWGHFYSKRLCDEILEIDPEGYVTRVSMVHYNTEEEIKGLVEVLKKILPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2RC85</accession>
    <name>M2RC85_COCSN</name>
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            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
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        <name evidence="12" type="ORF">COCSADRAFT_26593</name>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699727.1">
        <property type="nucleotide sequence ID" value="XM_007701537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RC85"/>
    <dbReference type="STRING" id="665912.M2RC85"/>
    <dbReference type="GeneID" id="19135518"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_26593"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_2_0_1"/>
    <dbReference type="OMA" id="IHESQDV"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="374"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD64444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="489" mass="52716" checksum="338E652C99140AEC" modified="2013-05-01" version="1">MASNPSQAPVLETIDKTSGHEFALPAKRIHDGDDVTAFLASRAYADIMTFIFQLNTAMIPRKIDLKEPGEEETAKEWTLNDKDVPYTPVVQNLAKLLDALTSIIDEAPPDPGPRRFGNVSFRTWYKLVREQASGLLDQHLPQHVLDFKSTSDVSAKSELEAYFLGSFGSSQRLDYGTGHELSFLAFLGCLWKLGAFPESQAGDQERGIVLGVLEPYLVLIRRLILTYTLEPAGSHGVWGLDDHSFLPYIFGSAQFSPAISTPGDVAAEGSLPTAPNPGDVAKAPAVERERKRNMYFSAIGFIYDVKKGPFWEHSNILYDVSGVKAGWAKINKGMIKMYNAEVLSKFPVVQHFPFGSLFSFSPDANARKIQATVHTTSQPKAAVSATPRPQPALRDPLADTTAMPSTARPGGAVGTAAPWARGPVAAGPGVPSGVNQPTKAPWGSRTPAPPPTTMPGAGVGTAAPWARKKEDGAAGEGQQNTKAPWADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2RCB8</accession>
    <name>M2RCB8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_90456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700248.1">
        <property type="nucleotide sequence ID" value="XM_007702058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RCB8"/>
    <dbReference type="GeneID" id="19141349"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90456"/>
    <dbReference type="eggNOG" id="ENOG502RJ8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033567_0_0_1"/>
    <dbReference type="OMA" id="CQRWKGL"/>
    <dbReference type="OrthoDB" id="59699at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF16">
        <property type="entry name" value="DUF2235 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="11"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="521" mass="58203" checksum="B151D509A5B77137" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2RCJ2</accession>
    <name>M2RCJ2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_326338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700283.1">
        <property type="nucleotide sequence ID" value="XM_007702093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RCJ2"/>
    <dbReference type="GeneID" id="19136851"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_326338"/>
    <dbReference type="HOGENOM" id="CLU_3055905_0_0_1"/>
    <dbReference type="OMA" id="WALVFWG"/>
    <dbReference type="OrthoDB" id="10282190at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="54" mass="5953" checksum="C8331E527FEC27CD" modified="2013-05-01" version="1">MQLGFGSFVAFVPLDAWAWALVFWGTLLPSWTYSGSGPFSQRELLLSIVCQGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2RDB6</accession>
    <name>M2RDB6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_36191</name>
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD66619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="540" mass="58753" checksum="26BF99A06BE8655A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RNG4</accession>
    <name>M2RNG4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-arabinitol 2-dehydrogenase [ribulose-forming]</fullName>
            <ecNumber evidence="5">1.1.1.250</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_79164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; D-arabinitol metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.250" evidence="5"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695849.1">
        <property type="nucleotide sequence ID" value="XM_007697659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RNG4"/>
    <dbReference type="GeneID" id="19140715"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_79164"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="RAQYRFQ"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047038">
        <property type="term" value="F:D-arabinitol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000240">
        <property type="entry name" value="SDR family oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="300" mass="31756" checksum="55236638BA1161E0" modified="2013-05-01" version="1">MAGDGEDRAALVNRQLPEMTLSTADNPVTAPQPPPEGLSAAQRAQYRFQVKGNAIITGGTGTLALEAARALLEHGATGLALWDLNPDGAFSSVKTLHSQFPHARILTIAVDVRSDTAIATALSDTLKVLGEISTLLCFAGVVGCTHAIDMTADEWRRTHDVNLTGSFLCAQAVARQLRDQGTGGSIVFTASISAHHTNFPQPQAAYNASKTALLSLAKSLAAEWSSFGIRVNCVSPGYMDTILNEGEGLERARNSWNARNPMGRMGHPWEITGAVVLLCSQAGRYINGTDIIVDGGAMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2RPZ7</accession>
    <name>M2RPZ7_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_80711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696193.1">
        <property type="nucleotide sequence ID" value="XM_007698003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RPZ7"/>
    <dbReference type="GeneID" id="19140797"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80711"/>
    <dbReference type="eggNOG" id="ENOG502RJ0M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1189819_0_0_1"/>
    <dbReference type="OMA" id="KYECIEA"/>
    <dbReference type="OrthoDB" id="3799586at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="212" mass="22585" checksum="803BFC2BA6FB1ED7" modified="2013-05-01" version="1">MVKNVPVSSTTKPTMLPSADSITDRSRKFYDGTYTWDSDGFIDGMGVYRTFDCYDPDARAPTPLPPIFMSDEEKDGVLQCGAGADMETLTLAPDTGNEGITATARCDKSSHSHADKKHFIGKIEGALQDTITPPTSPVVKKPATATVRNKHPGPITPPKDAESMVQTPSSSSSGLSDCPSDLSEWDVGPPVSIHADSMTYCGTAEKVPESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQA3</accession>
    <name>M2RQA3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_196637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696279.1">
        <property type="nucleotide sequence ID" value="XM_007698089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQA3"/>
    <dbReference type="STRING" id="665912.M2RQA3"/>
    <dbReference type="GeneID" id="19133989"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_196637"/>
    <dbReference type="eggNOG" id="ENOG502SCPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_3_1"/>
    <dbReference type="OMA" id="MAYFEHE"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="301" mass="33795" checksum="F1CD5E5B20F7D68B" modified="2013-05-01" version="1">MPLEHSSSGRTYVLHPNGQRSHYVLNDFTDPWKPHETILIQHGFGRHSAFWYHWIPALSRHYRVARRDLRGHGYSGYPDQKQTVSSTEDGIAENDKREEDRDYEYNVDTIIGEIIDTLDQLGLQKVHFLGESTSGMLGEILAARHPERLLSLTICSSPTHLPPPALQMFAFGHKDWPTACRQLGARGWTEALARVPGTIPISDSGYLPWYLGQVEVGDGEGLAQYAEFLSTLDARPWLEKIKVPTLILSPTQSVAVKVEDMEALRDRIPGSQLVPIDGPGHEIYVTQAEECQQAFLGFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RS98</accession>
    <name>M2RS98_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_210241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694778.1">
        <property type="nucleotide sequence ID" value="XM_007696588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RS98"/>
    <dbReference type="STRING" id="665912.M2RS98"/>
    <dbReference type="GeneID" id="19134383"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_210241"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009043_1_0_1"/>
    <dbReference type="OMA" id="LKMETHH"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="378"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="661" mass="73867" checksum="A4899B5005D57221" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT53</accession>
    <name>M2RT53_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_106654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694978.1">
        <property type="nucleotide sequence ID" value="XM_007696788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT53"/>
    <dbReference type="GeneID" id="19130003"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_106654"/>
    <dbReference type="eggNOG" id="ENOG502SJNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015492_0_0_1"/>
    <dbReference type="OMA" id="DRSHYSH"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="464"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="698" mass="81216" checksum="878C1602401A375F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RV20</accession>
    <name>M2RV20_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_102302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705412.1">
        <property type="nucleotide sequence ID" value="XM_007707222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RV20"/>
    <dbReference type="STRING" id="665912.M2RV20"/>
    <dbReference type="GeneID" id="19129792"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102302"/>
    <dbReference type="eggNOG" id="KOG3468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154847_2_0_1"/>
    <dbReference type="OMA" id="YRDSCAN"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD58958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="93" mass="10995" checksum="3EEE3AA8B73FA14D" modified="2013-05-01" version="1">MTVTDSIKHAIGLGEPRKATREEMSAAKLPLPYRDSCAHLLIPLNRCRYEEYYLPWKCENERHSYEKCQYEEFKERVKKMDELRAAKGGERSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2RVN0</accession>
    <name>M2RVN0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">O-acetylhomoserine (Thiol)-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_348605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705526.1">
        <property type="nucleotide sequence ID" value="XM_007707336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RVN0"/>
    <dbReference type="STRING" id="665912.M2RVN0"/>
    <dbReference type="GeneID" id="19137906"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_348605"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="OMA" id="IGNPRCS"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46501" checksum="435E3E667C01DD23" modified="2013-05-01" version="1">MADAFAPFKVDVGLESERAFDTRQIHAGAKPDSATKARAVPIYATASYVFTSSEHARRPTVEVLEKRIAALEGGTAAVACASGQSAVFQTIMCLAHTGDNIVASTALYGGSYSLFKTLLPRMGVSVRWVSTDDAEAYRPLIDDRTKLIFVETVGNPVVSIPDLQGIADIAHEHNVPFVVDNTFGAGGFWCPVVSFGADIVVHSATKWLGGHGTTVGGVVVDSGRFNWKKAGARFPHLTQTSDGPMGFSFASNFNNVAFAMALRIEVVMEVGSVLNPFAAQQILLGMETLSLRCDRIAANALHIAQFLADHDRINWISYPGLPTSKYYERAKKYLRRGFGGVLSFGVVGGTVGSKAFVDGLRLISNMTNVGDCKTMATHPWSSTHTIMTEQDRLNAGITEDLIRLSVGTEDVNDIINDLLRGLKAIPDQFIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXB5</accession>
    <name>M2RXB5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_252784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704689.1">
        <property type="nucleotide sequence ID" value="XM_007706499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXB5"/>
    <dbReference type="GeneID" id="19135252"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_252784"/>
    <dbReference type="HOGENOM" id="CLU_2263522_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="103" mass="12076" checksum="85435071DF89DCDE" modified="2013-05-01" version="1">MRDKIYVCIYKKKLESSFRSKKKQSKAKQANHALARHKKRQRRKVAKKRKASSKGKKRKRSSAVVSRATKQRNSSEKKKKQTNSERSRSTRGKKEKEEGNDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2RY19</accession>
    <name>M2RY19_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_40415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704077.1">
        <property type="nucleotide sequence ID" value="XM_007705887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RY19"/>
    <dbReference type="GeneID" id="19139732"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40415"/>
    <dbReference type="HOGENOM" id="CLU_2009328_0_0_1"/>
    <dbReference type="OrthoDB" id="5599418at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="124" mass="14473" checksum="28224044C8DEF340" modified="2013-05-01" version="1" fragment="single">RKHIRPPPITIDLIINNVVNATALIDYRCLCYALINRKFAYRHCLERFQIPTQIIKGVNNKLSEINKVARFSFKLYGYEESAYAYVMDLSSSENVYLERGWIDHRDVTIAPAKKSIFIHLKGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2S2P8</accession>
    <name>M2S2P8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-splicing factor cef1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_39208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702595.1">
        <property type="nucleotide sequence ID" value="XM_007704405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S2P8"/>
    <dbReference type="STRING" id="665912.M2S2P8"/>
    <dbReference type="GeneID" id="19139443"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39208"/>
    <dbReference type="eggNOG" id="KOG0050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009082_0_0_1"/>
    <dbReference type="OMA" id="KMGMAGE"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
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    <dbReference type="STRING" id="665912.M2S4F3"/>
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    <dbReference type="OrthoDB" id="5390017at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="235" mass="25871" checksum="4AD5EA88FE7ECA48" modified="2013-05-01" version="1">MTMAGWTMDVALSRKRSRLALEDDEDLPPKREPSPAPSPFGDTLKKSKTQCELEELEIIRPEDAWTVDVDAILASNVLAAPPDSKLQAHNNWARYQRGQSITVLCVQGNVQIHYELLCSALPDLYKLSPSLQALVLCHDPSTHRLSPSAPFSLPLVQAATTSNNHFVRLGLLHPLGGGKFPLDALVVLDRNAKRRLVLPFGWGAGKHAGTPAGRSIQMTLMRLLRSCVEQLQQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6W0</accession>
    <name>M2S6W0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_45406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445737">
        <property type="protein sequence ID" value="EMD58095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706204.1">
        <property type="nucleotide sequence ID" value="XM_007708014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S6W0"/>
    <dbReference type="GeneID" id="19140203"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_45406"/>
    <dbReference type="HOGENOM" id="CLU_2339077_0_0_1"/>
    <dbReference type="OrthoDB" id="3796133at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13551">
        <property type="entry name" value="HTH_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="93" mass="10650" checksum="4E52C226144090EF" modified="2013-05-01" version="1" fragment="single">AEISRNRMPGSELSDAQRIYILAQAEGGCSTSEIATRLSCTRRAVNKIIHQWDTEGTYTKHDRMGRPPKLTSRDHRQLLRAVKKDPKIEYRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2S744</accession>
    <name>M2S744_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_70160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445670">
        <property type="protein sequence ID" value="EMD58190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706111.1">
        <property type="nucleotide sequence ID" value="XM_007707921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S744"/>
    <dbReference type="GeneID" id="19140462"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_70160"/>
    <dbReference type="HOGENOM" id="CLU_3037869_0_0_1"/>
    <dbReference type="OrthoDB" id="3689183at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6250" checksum="9F3C9B23176E3016" modified="2013-05-01" version="1" fragment="single">MYANKLQDNWVELLPTAQLAYNSTKSATTKHSPHYANYGYEPVAHRDPKDIESIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7D7</accession>
    <name>M2S7D7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701027.1">
        <property type="nucleotide sequence ID" value="XM_007702837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7D7"/>
    <dbReference type="GeneID" id="19139121"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37896"/>
    <dbReference type="HOGENOM" id="CLU_512869_0_0_1"/>
    <dbReference type="OMA" id="HQHISFT"/>
    <dbReference type="OrthoDB" id="3685638at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="505" mass="55245" checksum="306543A2D4CCE338" modified="2013-05-01" version="1">MSHQAHQHISFTEPFVAMSSCETDSDLGILQPSHARRRTLKREVSKSFLHTCSYLGKRRKRSQSVPETSIDYPYLVLPPGGYVMSPSSSNVSSNHSVLTTPLPSPAIDDTEHGLEHGWRQSQVAELLNRLNFRLKRLFGSRRGSVEDGDPSVASSDTRHSSLSFNLRGLADPANIDCTHEYQIWNGSFQLPNETLQAQGNAAIQTHVNSHRGSNVDMDLDRLDWFRAHGTQGSDCEPRTRKDSFFSFGDFLRSRRSSKVDKGKGRMTIENDTAVGPLDEMALLSSGSTRLVVETRCLGEIGVLPRVSMETMLPLLPKEPQDVPQAEFSSLESSTPSLHCSESSTPPGEEAQERQMHRAQPVSSCITIPLLLEGQAGDAKAACGSPASSVSSMDDQLVPIRPATPVLVPTIVSSPSPLTPMQSLSLGPRQHDMEWSRCSSSKCRSRVSLCEMLSDEAPRTVCCCSCVRGGGNRASGGLGLRKSLDDRCWWDGDDGGKNGATRRVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7I4</accession>
    <name>M2S7I4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_120094"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Oligpept_transpt"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="OPT"/>
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    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF03184"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700371.1">
        <property type="nucleotide sequence ID" value="XM_007702181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S826"/>
    <dbReference type="STRING" id="665912.M2S826"/>
    <dbReference type="GeneID" id="19138931"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37238"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
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        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="108"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD63453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="569" mass="61749" checksum="5B98B6BFC6197D87" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8H0</accession>
    <name>M2S8H0_COCSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_329824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_329824"/>
    <dbReference type="HOGENOM" id="CLU_2739849_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="71" mass="8557" checksum="82977FC2843F70A6" modified="2013-05-01" version="1">MQRHYRWQRQRKKGRERERETAKKPKVRVTYIVCIWVTSYLSYLTGPPPFPSHHITTLPFPGSKQKVSMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8V6</accession>
    <name>M2S8V6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_190956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SBGS">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="178"/>
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    </feature>
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    </feature>
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            <end position="213"/>
        </location>
    </feature>
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            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="493" mass="56176" checksum="9D5C3EB64BE407C6" modified="2013-05-01" version="1">MGTLTADCPRLDIHCPHKLATSCRLTSTPNCCACADERVHSRTYRVYIDGVGFVNRGTRWQGYCWFCKEFWSNRLAATDPPLEIAQTRIPEIPDQTEFLERWWEFHQGYRIAKLPDGTEQRIAVIGEPFHEVSPGLLPRTLDQLRAGVENNALRPENRLRRRRLTSEEDRPEEPQQSLEDALDDLLREAEETPNVNSTVPTEPQSSVTPQIQEDPSEPPRPMTRREAQMQLARERFARVFGSREELEQDDYESPLTQMYTRAYDRHRQAEQRRAEGTEVAPQLDSLSLQDRREIEEQLLWGVMRESQSISESLEPATEVWSYAPRRRGVDGEDAAVTEVRWLRNSGEIDVSAERMAYFENSGAEGTEAARRLVVAYRQSQAEDEARIRAIFANPNGESSSAAPIATGWWSHIRPQLSGIAGGTTQPLAEMHNIRLDFEQELARMRAARPPSPPVVSLDNQPDRPPPKSEEEMTKVLACQTWTYTGASDKVSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCK4</accession>
    <name>M2SCK4_COCSN</name>
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        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_249936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007706197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCK4"/>
    <dbReference type="STRING" id="665912.M2SCK4"/>
    <dbReference type="GeneID" id="19135190"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_249936"/>
    <dbReference type="eggNOG" id="ENOG502QRZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005335_0_0_1"/>
    <dbReference type="OMA" id="KMYHLSG"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="695"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="925"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD60200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120073" checksum="4DF6144DE03EA40B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCU3</accession>
    <name>M2SCU3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_150015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703690.1">
        <property type="nucleotide sequence ID" value="XM_007705500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCU3"/>
    <dbReference type="GeneID" id="19131522"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_150015"/>
    <dbReference type="eggNOG" id="ENOG502SSR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5423884at2759"/>
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    </feature>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
    <sequence length="203" mass="22521" checksum="0D0617D5D35EC33D" modified="2013-05-01" version="1">MPAFRQHLDAVAAQIDRIAPRDAILTPRQPLVDAPAIAFDAPNAALLAKRQNVIYTQQGIIPTYYDLSGPEPGTVVGIVLGSVAGFLLICWLLQTLVNGSRSAGTTTAMAGEEEIVVRRPRRNSHGGRSSRRRSEVREVSRSPRTSGARSQIIVEERRQPVRARSIVVEDRHRVPGDNVVEVIEEHEDYRERRGSRRSGPGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">COCSADRAFT_39763</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD61065.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>M2SHY0</accession>
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        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporineae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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            <end position="288"/>
        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="802"/>
            <end position="823"/>
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            <position position="158"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <begin position="162"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <ligand>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD61995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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        </source>
    </evidence>
    <sequence length="823" mass="90996" checksum="646AF2DD55845986" modified="2013-05-01" version="1"> </sequence>
</entry>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697632.1">
        <property type="nucleotide sequence ID" value="XM_007699442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SHZ7"/>
    <dbReference type="GeneID" id="19138216"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35318"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874333_0_0_1"/>
    <dbReference type="OMA" id="HPEEKHL"/>
    <dbReference type="OrthoDB" id="3512346at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025441" evidence="2">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="260" mass="30642" checksum="C3832157339D2CDF" modified="2013-05-01" version="1">MRFSNLVTVALMATSAASFPISAAGNAPAPVEGLEGLMGRNAEPQKLKVDKREPQKLKVDKREPQKLKVDKRDPEPQKLKVDKREPQKLKVDKREPQKLKVDKREPQKLKVDKREPQKLKVDKREPQKLKVDKREPQKLKVDKRDPEPQKLKVDKREPQKLKVDKREPQKLKVDKREPQKLKVDKREPQKLKVDKREPEPQKLKVDKREPETPKLTLDKREPEPQKLKVDKREPQKLKVDKREPQKLKVDKREPQKLKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJF0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_288336</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_2454590_0_0_1"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="89" mass="10188" checksum="93531E779D2A35E7" modified="2013-05-01" version="1">MSIMVICYSFSYFPLLRYLAVGVFLPCFLTFSVASLSSHTGKHRSIATTISGFFFFWRGERSDECDGGFLHAFNTVKRKIKVGWSKCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJF1</accession>
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            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
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        <property type="protein sequence ID" value="EMD62475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701836.1">
        <property type="nucleotide sequence ID" value="XM_007703646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJF1"/>
    <dbReference type="GeneID" id="19134589"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_221284"/>
    <dbReference type="eggNOG" id="ENOG502SIAS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="OMA" id="FCEIFYT"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD62475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="402" mass="44380" checksum="A5A2DABC6C892F12" modified="2013-05-01" version="1">MKDRSGEILAIGITFLLLSWLTVGLRCFVRVHMVKGFGIDDYTMVVTLLFFTGYLISQIGGAINGSGVRRIHLTDESAQTALHFWFFCEIFYTLSTCMLKISVGFFLLRITIVPLHIWIIRLIMVVSGLVGIAYTSVVIFQCKPISYWWDLNPNAVGSCLSPALVMNFTFVVSGLNAFADWVFAILPVLIVQGLHMKKRMKVVVASVIALAAIGSTATIIRLPYTTTIKGYKGDFLFRTTDFAIWSTIEVGLGISAGSIATLRPLLKQAFEITRSASAMPWSKPSLKSGQEQSGHQLSVIKPSIQKSITITTSRARRESKESDEERFLGSSMPSEAWQQQQGLPGYITSTVLDEQAARASMDRSRKHGQKQNRRGSPGGSSQSTVDSKESGKAPKAHVHERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2SK41</accession>
    <name>M2SK41_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_223312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701994.1">
        <property type="nucleotide sequence ID" value="XM_007703804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SK41"/>
    <dbReference type="GeneID" id="19134632"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_223312"/>
    <dbReference type="HOGENOM" id="CLU_2984414_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="72" mass="8210" checksum="3697C77573B6A590" modified="2013-05-01" version="1">MVAWFLTSSLSQALLHLPGTHLAFLSEWSIKAVEMLTLLLMVLTPIYIRYPAASLHSYTIATSRRRIVCELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKJ8</accession>
    <name>M2SKJ8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_161394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701167.1">
        <property type="nucleotide sequence ID" value="XM_007702977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKJ8"/>
    <dbReference type="GeneID" id="19132096"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_161394"/>
    <dbReference type="eggNOG" id="ENOG502T48V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058880_0_0_1"/>
    <dbReference type="OMA" id="PEDWENR"/>
    <dbReference type="OrthoDB" id="3915128at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="487" mass="54848" checksum="B5847B5F4FAF4C74" modified="2013-05-01" version="1">MVLRLFVPEGEGQHPLTRKQPSGLAAQPDLITSPWRSSLGAAGLTGFLALVGRSRPGIFLRSAAFFSVVDLSWTATGLYGQREINRGVFKMENITPQSGKLLQSTTRWTAEDATLAGGVLGIVTALNPRAFPGAYGISRFIGAATVGCALGYKTGQIFITRIDPRLMSIIESSEKVIRRREYEKLQRDKEAKASLSFVGKLALKYHTSPYLQILRNPLQFSGAGGVGGMSSGQQHAKPSSRASQGLALSSSLQADTAQFTLIQVEFKADDLTGPDLEAGYRAYKDSLQTRDESAIQEWREKVLRHKQQAKIEINFLWKHLAGREKAFYLHVEEDRDKDILRRELQLLNNMTGDMIVRYAMLGYHEADADKQLRQKRRADNVSPPLTESDMLLKSTVAAQYDYRGPIIVTEQVRTNWTRQKEVLYHLEHILSQYEEMQPAEGSGVFEHRKQLRQNAEDLKRNVEATERLLHWFEVQVQQAEDKTKRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLY8</accession>
    <name>M2SLY8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_120606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701501.1">
        <property type="nucleotide sequence ID" value="XM_007703311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLY8"/>
    <dbReference type="STRING" id="665912.M2SLY8"/>
    <dbReference type="GeneID" id="19130453"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_120606"/>
    <dbReference type="eggNOG" id="KOG4129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019358_5_0_1"/>
    <dbReference type="OMA" id="QMTPGHE"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.20:FF:000008">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF20">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025917" description="DHHA2 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="DDH" evidence="7">
        <location>
            <begin position="66"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA2" evidence="8">
        <location>
            <begin position="275"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD63315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50683" checksum="074D19D2C9A7D36E" modified="2013-05-01" version="1">MKPIRVLLPGLMAVSHVAAAPQQVVLDALDKPSAKPIGVGHFSEWSRQTKKEFLVDWQAGKESEWILVQGNEGGDMDSMTAALTWAYHLEHATMNTSNPLKAIALLQTPSHALDLRPENKLALDNSQMTPGHEDLLTLDELPEDPETLSTKLKGIVLVDHSEPLKKWSTAKILSIFDHHKDHGTAPDADPRVFETAASCTTLVARQMLDELEKLDEEYHMPHELLELILSAIAIDSGGLTGDKTTKADIETSKRILARSNWRNDDLKDVMEDLDDELTKAQKDIDNLGLYDLLRRDWKSDAIDTPSPRTPAISVGFASIPYSMDEQILKTEFQELFDWFAIHAAWTAQANVDVSVSINKYKKHYKDGSKEKIREIVLVVRDDVRIDQDQADSLFKLVKDAIENNKEGIDFQPWHRADELAPRQMVWQHRSDAGRKVIKPLVEEAIMEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SME0</accession>
    <name>M2SME0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_194766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445657">
        <property type="protein sequence ID" value="EMD58311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705977.1">
        <property type="nucleotide sequence ID" value="XM_007707787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SME0"/>
    <dbReference type="GeneID" id="19133908"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_194766"/>
    <dbReference type="HOGENOM" id="CLU_1864784_0_0_1"/>
    <dbReference type="OMA" id="HTARLHH"/>
    <dbReference type="OrthoDB" id="3682436at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="169" mass="18609" checksum="8EE74940F60EE366" modified="2013-05-01" version="1">MALQVELSGHFDVGPMLTGVPGQCRTGEIVKNASAGFYFFDTITRPHSSDVYLYTSFILARQAQFLRHRALRKHDPLCVGAYIAPSPLRGACSALIVGFTRRSRRSKESPTDGTATRQPSVSCSLRTDIESLLDRWLHTARLHHSHKRVSLETAPSSAAPGLSNTVAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNT3</accession>
    <name>M2SNT3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_33708</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695609.1">
        <property type="nucleotide sequence ID" value="XM_007697419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNT3"/>
    <dbReference type="STRING" id="665912.M2SNT3"/>
    <dbReference type="GeneID" id="19137275"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33708"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="OMA" id="CQFANVQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="471" mass="52523" checksum="9EE49DF2C467A6E1" modified="2013-05-01" version="1">MSNYALPKSHQDLMEKSLVDTDQEVAQIMEKEIQRQRESILLIASENVTSRAVFDALGSPMSNKYSEGYPGARYYGGNEHIDSIELLCQKRALETFRLDPEKWGVNVQCLSGSPANLQAYQAIMRPHDRLMGLDLPHGGHLSHGYQTPQRKISAVSTYFETFPYRVNLETGLIDYDQLEQNALMYRPKVLVAGTSAYCREIDYKRMREIADKVGCYLLMDMAHISGLIAAGVNKSPFEYCDIVTTTTHKSLRGPRGAMIFFRKGVRKTDPKTGKETLYDLEGPINFSVFPGHQGGPHNHTITALAVALKQAQSDDFKQYQQQVIKNAKALEVAFKSMGYKLVTDGTDNHMVLIDLKPFSLDGARVEAVLEQVNIACNKNTTPGDKSALTPMGIRIGAPAMTSRGLGEEDFKKIANYIDTCIKLCKKIQSELPTENNKLKDFKSKVASGEVQEINDLKKEIAAWAVTFPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNT6</accession>
    <name>M2SNT6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_68314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700929.1">
        <property type="nucleotide sequence ID" value="XM_007702739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNT6"/>
    <dbReference type="STRING" id="665912.M2SNT6"/>
    <dbReference type="GeneID" id="19140450"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_68314"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_1_2_1"/>
    <dbReference type="OMA" id="QGWWEFG"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD63965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="102" mass="11018" checksum="6863F9456968590E" modified="2013-05-01" version="1" fragment="single">IFELEVIPQLCNPMNNMHGGAMALLADMTTTMAGAPIARQGWWEFGGVSRTLSVTYVRPALLGTTIVVTCVLRSVSSRMSVIQFIARDKVTGKLLALAEHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP32</accession>
    <name>M2SP32_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_31246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705533.1">
        <property type="nucleotide sequence ID" value="XM_007707343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP32"/>
    <dbReference type="STRING" id="665912.M2SP32"/>
    <dbReference type="GeneID" id="19136403"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31246"/>
    <dbReference type="HOGENOM" id="CLU_2015070_0_0_1"/>
    <dbReference type="OMA" id="ETNEYFA"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="123" mass="13605" checksum="750AEE6433F15A59" modified="2013-05-01" version="1">MDRNDIDVSILSLSAPGLAFASSAEEATKLCRSVNEYAKDISTSHPRRFGFFASVPSLTQIDVCLEEVRYSLDVLKADGVALLSSYDDKYLGHEDFCPLWEELHSRNAVVLFIQPLARLGAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP48</accession>
    <name>M2SP48_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BZZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_153641</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Hamelin R.C."/>
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                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <sequence length="245" mass="26972" checksum="19CB44B8CE92E944" modified="2013-05-01" version="1">MADARTLLRQQRAARQQAQKPQKQSPAPAAAPTAKKRKAPDQGGEEKKRTRTEEEAGVPAGFFDAGATNDDNDNDNDQVAPALVEESPTVADIQPPKPPAPVDPPLDAAAQAELDAFMTEMSTEKPTPQPAKSAYSGAVIEAAPMTAAQLAAQVREEQSEQRAKRDEEMEGEKEDAARALEDEFEEMEGLEERVKRLREQREALRSVSGRPGDVQNQEPAAPQNEEDEESESEDEDWDDWRFRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ58</accession>
    <name>M2SQ58_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_155567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694718.1">
        <property type="nucleotide sequence ID" value="XM_007696528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ58"/>
    <dbReference type="STRING" id="665912.M2SQ58"/>
    <dbReference type="GeneID" id="19131704"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155567"/>
    <dbReference type="eggNOG" id="ENOG502QW0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_6_0_1"/>
    <dbReference type="OMA" id="YIAHTAC"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="657"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="748"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="658"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="748"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="907" mass="100202" checksum="55959E9FD52639FE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ86</accession>
    <name>M2SQ86_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_102139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705036.1">
        <property type="nucleotide sequence ID" value="XM_007706846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ86"/>
    <dbReference type="STRING" id="665912.M2SQ86"/>
    <dbReference type="GeneID" id="19129780"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102139"/>
    <dbReference type="eggNOG" id="ENOG502SD8V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202020_0_0_1"/>
    <dbReference type="OMA" id="RRITMVF"/>
    <dbReference type="OrthoDB" id="2155101at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="52" mass="6122" checksum="002D26939CB73720" modified="2013-05-01" version="1" fragment="single">RRLDPLFTISIGLAAAATRIQREEREKGRDVRQSWEVLRRRWGIFLKGEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQJ6</accession>
    <name>M2SQJ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_341502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
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            <dbReference type="ChEBI" id="CHEBI:43074"/>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
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        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
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    </evidence>
    <sequence length="100" mass="11335" checksum="1C6AB29F563D9078" modified="2013-05-01" version="1">MGYQNLRLSVGLHLTLLVGGIRIGCHHLKRLVTPRSLTKQYQLQSTIARDRHVRIMEVGPRDGLQNINQLVPQEVKTELIQRLAETGLQEIEAKSFVSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_257030</name>
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    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="665912.M2SR77"/>
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    <dbReference type="eggNOG" id="KOG2071">
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    <dbReference type="OMA" id="ARSDFAN"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
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    </dbReference>
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        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
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        <location>
            <begin position="577"/>
            <end position="603"/>
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    </feature>
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        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD59292.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="691" mass="74929" checksum="750FF9A55C56903C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRF1</accession>
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        <recommendedName>
            <fullName evidence="5">Deacetylase sirtuin-type domain-containing protein</fullName>
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        <name evidence="6" type="ORF">COCSADRAFT_102249</name>
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    <organism evidence="6 7">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705103.1">
        <property type="nucleotide sequence ID" value="XM_007706913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRF1"/>
    <dbReference type="STRING" id="665912.M2SRF1"/>
    <dbReference type="GeneID" id="19129789"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102249"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_1"/>
    <dbReference type="OMA" id="YHYWREL"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD59377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="274" mass="29994" checksum="35F48F285292EB1D" modified="2013-05-01" version="1">MDTSDTHTWSAFADLLAESSRVLCLVGAGLSAPSGLATWRGTNGLWNDINLKELASPKKFREDPVTVWSFYGERLLEALEARPNAAHHALAALANWHQGWLSINQNVDGLLEQTGHPMSRLLNIHGTLKIVRCTACDYSINVHKPEDVPFLLSLSNTDHKARSVALSDLPHCPRCANLLRPGVVWFGERLAAGAPDSVDEWMSEEHIDLVIAAGTSLQVFPAAEWVSTARACGASLAIIDAGDYEIVEEFDETDWFLKGDIAFVLPKIVDILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRG7</accession>
    <name>M2SRG7_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_155994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695054.1">
        <property type="nucleotide sequence ID" value="XM_007696864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRG7"/>
    <dbReference type="STRING" id="665912.M2SRG7"/>
    <dbReference type="GeneID" id="19131731"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155994"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="OMA" id="HRRLEYP"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="334" mass="37710" checksum="D8478FCCE8A21C97" modified="2013-05-01" version="1">MLNYPSTLSRIPPGLSSTPNMPLSNIDLVNQCDGFPYPDVNLETYLASINTYYQLRVSGHNYGLGYMLPSVVEVFRGVSNWEIDDKARILCLTAGSNAQERSAAVETTLLALRKTGHFKVLDKWRGELYAVYGKNKELLFNVERSASPLFGVITYGVHLTAFTRTRGEIKIWTPRRARTKQTYGGMLDNAVAGGIASGESPFESLVRECAEEASLPEELVRKNAKACGTVTYWYVRDERAGGETNLMQPEVQYVYDLELPEDTIPKPGDDEVEQFYLWTVDEVQEAMRNGEFKPNCSLVVLDFLVRHGILTTENEKDYIELVSRLHRKLEFPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS07</accession>
    <name>M2SS07_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_216164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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            <end position="298"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
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            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_99846</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20598" checksum="07188636F91F1E6B" modified="2013-05-01" version="1">MHDSVTSLPPSTRHIITHDAQGKSIVHSAPALQYYGLPGMGGAARSYATPSTPASLENEADINAYIAPTGPQSFTTRDIVSPGSGSHLIVCELAPGQASQMHQTVSVDYVVCTHGRLNMQTGSGEVIKLRPGDHVVQRGTMHKWINGSDTEPTRFIAVTVPCEPFKIPGTDKMLQEVHVEGSEAKDWDVSQL</sequence>
</entry>
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    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_306444</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="32"/>
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            <end position="287"/>
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        <location>
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    <feature type="domain" description="EF-hand" evidence="9">
        <location>
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            <end position="444"/>
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        </location>
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        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="810"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="883"/>
            <end position="906"/>
        </location>
    </feature>
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        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
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        <location>
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            <end position="862"/>
        </location>
    </feature>
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        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD65505.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117458" checksum="40E0D865654E387E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2STD0</accession>
    <name>M2STD0_COCSN</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_35581</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="Flavin_mOase-like"/>
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    </dbReference>
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        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    <sequence length="574" mass="65178" checksum="71A64D5D0CAB1081" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2STL8</accession>
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        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_35673</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STL8"/>
    <dbReference type="GeneID" id="19138448"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35673"/>
    <dbReference type="eggNOG" id="ENOG502QT25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043688_0_0_1"/>
    <dbReference type="OMA" id="EDGGHNF"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="378" mass="42817" checksum="CD042121073542A0" modified="2013-05-01" version="1">MSTLTVHGLTKGQIDEKILLLTHNLVNIHDTTGEFLLKLDDGRIIDTKGWDGWEWTHGIGLYGLWHYYTLTGSMATLDIIKGWFDKQLAKGTTKNINTVSPFLSLAYLYEETGNKTFVPWLDTWAEWVMHGLPRTKFGGFQHETYNSFNKDELWDDTLMMSALPLAKIGLTLNRPEYVEEAKRQFILHCQYLCDTSTGLFYHGWKWEDKGGLEVGHNFGKARWARGNSWLTIAIPDFIELLDLKESDPLRQFLVGILESQCRALVKCQGESGMWRTLLDIPISEGSYEESSATAGFAYGMLKACRKRYISGDVFLESAVKAVKAVMGKINAEGELTETSFGTAMGHDLQHYKDIKITSMPYGQAMAIMALGEFMRTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUV3</accession>
    <name>M2SUV3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_34662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697466.1">
        <property type="nucleotide sequence ID" value="XM_007699276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUV3"/>
    <dbReference type="STRING" id="665912.M2SUV3"/>
    <dbReference type="GeneID" id="19137785"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34662"/>
    <dbReference type="eggNOG" id="ENOG502S3Z0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_5_2_1"/>
    <dbReference type="OMA" id="YWIEANI"/>
    <dbReference type="OrthoDB" id="3679575at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD66065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="236" mass="26643" checksum="A467B510F9F6BB4A" modified="2013-05-01" version="1">MTKAKNIAVHKIDKSIWHLQDSDRILKRGPNVKVAEAEALRFIASSTHVPVPEVFGAYEKDGFGNIFMSRVIGTPLHDVLHTFDEAQVERVTTQLSGFVQSWMGLRGDFFGSMGFEPCRDVFFQHLPAANMPDREYGPFRSRTEYCNGLIDALRNSRPYGRFDANDAHQIERIQRLGDGCAVFCHGDLTPDNILIDDQLNVVAILDMGVSGFSIPEREYFEAKSRARNSLWSSMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVB6</accession>
    <name>M2SVB6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_24372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697436.1">
        <property type="nucleotide sequence ID" value="XM_007699246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVB6"/>
    <dbReference type="GeneID" id="19135061"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_24372"/>
    <dbReference type="HOGENOM" id="CLU_1151701_0_0_1"/>
    <dbReference type="OrthoDB" id="10633670at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="241" mass="26680" checksum="5131F146830D7F88" modified="2013-05-01" version="1">MAVPKGPYHAIAAQCCQSCSLFPCLRIRSRSNKMRFLLALAFSLTISSVSAKYACQTQFLKGVGGECRSDWDCCQCDSGSSGFLTCKGDGSSSTGRRSTTSCMLISRISFDNVGTKISINGQKVVVNSCVDKRVWLCRQKVAARMEKIYSKLSKDAKSKYLYLCPLQLVVHHAWICTSQLKWQAPTYTHGSAYTMSAMLDNKLQRFQKRTKARHEGGIAAFRTCCTAAVGRRYFLPTAKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVG9</accession>
    <name>M2SVG9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_39548</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703057.1">
        <property type="nucleotide sequence ID" value="XM_007704867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVG9"/>
    <dbReference type="STRING" id="665912.M2SVG9"/>
    <dbReference type="GeneID" id="19139517"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Barry K.W."/>
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                <person name="Dhillon B."/>
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                <person name="Kosti I."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703382.1">
        <property type="nucleotide sequence ID" value="XM_007705192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SW31"/>
    <dbReference type="GeneID" id="19134939"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_238754"/>
    <dbReference type="HOGENOM" id="CLU_1434225_0_0_1"/>
    <dbReference type="OMA" id="LARWNWM"/>
    <dbReference type="OrthoDB" id="3689125at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="229" mass="24976" checksum="DB53017FD873FBB9" modified="2013-05-01" version="1">MSHHPKSWQLACAMFGALSRCPPLPSSVRALRATEPLRCPLLDAGTHTRDIGSSYETVGVLDSLWLAATLLRAGSASMFTCGRCRGLAAWPQRKVPSKKNSRKSALTALGHPGSIVEAKSTFAARRNLWTGMLARWNWMICTQHQIMEKRPTSRDVAVGRPGEAHQLRRSAGGTAVTTRLCADRGMPMPMMRDVNHGEIDTRRGGLSATTHSHKHGLARSTYLVPGARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWF0</accession>
    <name>M2SWF0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_39046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702559.1">
        <property type="nucleotide sequence ID" value="XM_007704369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWF0"/>
    <dbReference type="GeneID" id="19139407"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39046"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="314" mass="33475" checksum="68513C920F78CBB2" modified="2013-05-01" version="1">MPDSIAKVKQEGVSKELSEPIPETGSFEGMRGIRSVAGDLGDQRVKGKVIIVTGANSEIGIGRASAHQFARNGARAIYICDFSDSHLEKHKRQLNTLYPSTDVHIRQFDAADEAAVKKVCQDALDAYGRLDVFFANAGIASGRVFWEETTEGFMNMMRTNALSVFLAAKYASRAMLKTSDQKPYPSGSIIATASVAGLRSNAGPTDYAASKAAVISLMQTCAYQLTGSGIRCNAVCPGLIETGMTRVTYDAARKRGSEKKIGQLNPLRRGGQPDEIARAVLFLASDEASYVNAQAWAVDGGLSGGLPFVPGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXW5</accession>
    <name>M2SXW5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_81637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696889.1">
        <property type="nucleotide sequence ID" value="XM_007698699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXW5"/>
    <dbReference type="GeneID" id="19140843"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_81637"/>
    <dbReference type="eggNOG" id="ENOG502QS4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="OMA" id="ARGHPEN"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="50"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD67160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="378" mass="42578" checksum="F2120DC65AE37334" modified="2013-05-01" version="1">MLGRAAPALRPSLFSPIRSPCLRRGFAQETSFPKPLKLKGVLNPLKQFRVTPTVGTEFPEANLVDMLNAPNSDELLRDLAITVSRRGVVFFRNQNDMNNDLQKKMIQRMGELVGKPQESTLHIHPVLNPRQAMGGDDLEISTINSRQRKAVNGKATPRDLGNARQALESWHSDIQSEQVPSDYTCLRLTELPSSGGDTLWASGYEVYDRLSEPMRKFLEQKTANYTAPFFERIIKNANIKVYTDARGHPENTGTPLKAVHPVVRTNPVTGWKSVFAIGAYVRPGSINGLTPPESEMILDWLMNIVLRNHDLQCRFRWQGPNDMAIWDNRSMVHNATMDYDDFGERFGQRVCGIGEKPYFDPNSKSMREALAEEGEIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXX9</accession>
    <name>M2SXX9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_233849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702943.1">
        <property type="nucleotide sequence ID" value="XM_007704753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXX9"/>
    <dbReference type="GeneID" id="19134829"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_233849"/>
    <dbReference type="HOGENOM" id="CLU_2305843_0_0_1"/>
    <dbReference type="OrthoDB" id="10311709at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025912" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10868" checksum="D596EB6DEE0FEB09" modified="2013-05-01" version="1">MIKHVSALVVLRILFSLQESLSYVISFVGVSVDVCYRPSSCSCKLESVVAEKELSNPGNRAHLSCTERLSMRCNSTRVSVNCSHQLCSITIAEDAEVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYM1</accession>
    <name>M2SYM1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_352308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697085.1">
        <property type="nucleotide sequence ID" value="XM_007698895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYM1"/>
    <dbReference type="GeneID" id="19138144"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352308"/>
    <dbReference type="eggNOG" id="ENOG502T70T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401696_0_0_1"/>
    <dbReference type="OMA" id="RPSSICE"/>
    <dbReference type="OrthoDB" id="5330058at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="685" mass="76957" checksum="ECCFF3A1B7877149" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T019</accession>
    <name>M2T019_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_156390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695671.1">
        <property type="nucleotide sequence ID" value="XM_007697481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T019"/>
    <dbReference type="STRING" id="665912.M2T019"/>
    <dbReference type="GeneID" id="19131758"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156390"/>
    <dbReference type="eggNOG" id="ENOG502SBQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162186_0_0_1"/>
    <dbReference type="OMA" id="INYHAAR"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="100" mass="11184" checksum="7E801569F10F988E" modified="2013-05-01" version="1">MVPKPQGSAVQSATHRPLPPLPKLRVRRPNKPEVNPCLGAMSSVLGCWASSGYSIQACAQLEQKLRQCMDAPRDPNQKKNNINYHLSRMYPKIVGPHKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2T266</accession>
    <name>M2T266_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_350248</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696140.1">
        <property type="nucleotide sequence ID" value="XM_007697950.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2T266"/>
    <dbReference type="GeneID" id="19138016"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_350248"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001837_2_1_1"/>
    <dbReference type="OMA" id="TEHIYEV"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000003">
        <property type="entry name" value="Class V chitinase CHIT5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 13" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026185" description="chitinase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="16">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="17">
        <location>
            <begin position="213"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD68575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1772" mass="196276" checksum="A00831784B3CB8CD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2D5</accession>
    <name>M2T2D5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_357797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700506.1">
        <property type="nucleotide sequence ID" value="XM_007702316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2D5"/>
    <dbReference type="STRING" id="665912.M2T2D5"/>
    <dbReference type="GeneID" id="19138522"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357797"/>
    <dbReference type="eggNOG" id="ENOG502SV30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131040_0_0_1"/>
    <dbReference type="OMA" id="FLGWDIG"/>
    <dbReference type="OrthoDB" id="4483229at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="180" mass="18988" checksum="1B2AAAAC106F82A7" modified="2013-05-01" version="1">MPESELFPVICTVDIPTSILENFLKDAYTSSEQLVPGTSPSLVILTTSNTSDKGSDALTSSASRSPLQPFTSPFLGKSVENAAQHPVFQNASLFVVLDERSTRDNTALLAARDPNGTVDTVRVTFSAVQRTLISLDICSIGFAEIQSIADAQGNDGVYGTPVSTQGPQKGCPAPRKKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2Q1</accession>
    <name>M2T2Q1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1917 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_181745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700589.1">
        <property type="nucleotide sequence ID" value="XM_007702399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2Q1"/>
    <dbReference type="GeneID" id="19133319"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_181745"/>
    <dbReference type="eggNOG" id="ENOG502SG47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051869_0_0_1"/>
    <dbReference type="OMA" id="RPIYYKC"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28388" checksum="59793098ABD5DBEA" modified="2013-05-01" version="1">MSNKRKQESSSEQPSKLELFNQLQRQLNAWQLGKSVDDFIRRLPPLTTSVFTCPWIWAENPYHNPHDKSPYPHVALTLQIAACDYSRVLRDSPQESESLQEPITSLARNTHVLSRKWMLFPKSVDVTQVWKQIVVGVIENRLGSGCKVATDDGKEERLICVYTRNFQDTQDVVRILQELETIGLLSAGRLIYYKPDAYTYLDVRRENAAEYGLKAILYNSRSMLANSKGTESASLTQQKQCTLDGCFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2Z9</accession>
    <name>M2T2Z9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_118620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700655.1">
        <property type="nucleotide sequence ID" value="XM_007702465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2Z9"/>
    <dbReference type="STRING" id="665912.M2T2Z9"/>
    <dbReference type="GeneID" id="19130389"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_118620"/>
    <dbReference type="eggNOG" id="KOG0704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044516_2_0_1"/>
    <dbReference type="OMA" id="MSKLWEV"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="419" mass="44897" checksum="35B53BA776A81F3C" modified="2013-05-01" version="1">MSKMWEVDPETRSKLLEIQKTNDNNKCVDCNAPSPQWASPKLGIFMCLSCSGVHRGLGVHISFIRSITMDAFKGSELVRMAAGGNKPFQDFFNSHESNTKEGRTFESSTIQERYDSEAGDEWKERLSCKVENREFDKSNLPKRLPKKENTSMAGAGAGAPLSGRASAAGSRSQTPLGKARGSDTGFQRSGSPSLGTNAMSQKSKNEAYFAKMGQDNANRPEGIAPNQGGKYGGFGSEPDSWKKDDEPGAPPALDDFQKDPVAALTKGFGWLGASVSKVGKTGYEGWVKPGMAKLAEADLAAQARSTAGTLGQTLQSGVATANTQFTRFVEGDDSSSTARRGAPEPERKDFWESFGAAPKGPAKEKQDFWDEFASAGEARTSTTMEKKKPSGIGTSAMKKSGGSGSMGGSAKKDDEWDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2T315</accession>
    <name>M2T315_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_329429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55248" checksum="5F11532582889369" modified="2013-05-01" version="1">MATERLQTYEQKPRVIVLSDISNEPDDAESMCRYLLYSNEFETEGLIACTSTWMKNEVHPEDMEKIIDAYAGAVDNLNKHVHPKWQYPTADHLRGLIRKGAETYGMSAVGTGTELSAGGQLLYDRIVAPSIQPLWILCWGGTNTLAQALLKVDDDYDPDDSKRLLSRLRVYAISDQDDTGVWIRNNFPDVFYISSVHGWNQYGLAAWTGISGDRYYGFDQGGPDFTKMEKSWIKENIQIGPLGSAYPDYLFIPEGDTPTFLYLIQNGLGVPDCPHYGSWGGRYNRTDVSSEGVNSNHYSDAADRVQVGDRTYTSNHATIWRWRDAFQNDFAARIKWTMESDFAKANHHPVINISGFKGLAPAQITAEAGSAITLDASGTYDPNEGKLTFKWWHYREPTATQWWVDAEVAELAIKKLDNEGRKVEITLPPPQKSAVEFTSKQPVVQGQLLHLILEVTNDGTPSLTSYRRLLIQATNKELRGGKDGGATGDATKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5G2</accession>
    <name>M2T5G2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_131675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694920.1">
        <property type="nucleotide sequence ID" value="XM_007696730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5G2"/>
    <dbReference type="STRING" id="665912.M2T5G2"/>
    <dbReference type="GeneID" id="19130825"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_131675"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040954_0_0_1"/>
    <dbReference type="OMA" id="RRSADHN"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="426" mass="46875" checksum="3DAD0C29859380C0" modified="2013-05-01" version="1">MSEKVNTEKPPESPTTARELDFDDDNDAPAASTAEHTASPPPASKSPKPGVRFNEEATEIPPQKPPRPVDPQVQAQNTLIEAFPTVDSNVIKAVLVASGGKVEPAFNALLSMSDPNFKAEEAPPPQPPRPQPRSQLEQDEIFARQLAQHYESQGGSGPQRPRQQGSHQRQGEPEREYSFFDDDLPEIRKNIEQGFKETQQTVTKWISNFTKKLDGEMEEYDRYGNPQYTGRTAPPQQRQNFGPSQSDQMHGIRKSAEQRRSADHNRYDADNRVIGDDFAKLELRDNDSVPQRSSSRPHANPDLFKPTPVSPPQSGPVDEVDALYRNPSPSNPGSQGKSGGKKWQPLTSVAPNPEPDEHDPFSLGDSDDDEKDAKKQDTNPADTERLKNAAQSSGEAPPSGKLKPAERSGSVSQKDATAEALLKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5N0</accession>
    <name>M2T5N0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_21932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694082.1">
        <property type="nucleotide sequence ID" value="XM_007695892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5N0"/>
    <dbReference type="STRING" id="665912.M2T5N0"/>
    <dbReference type="GeneID" id="19134558"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_21932"/>
    <dbReference type="eggNOG" id="ENOG502SKH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_3_1"/>
    <dbReference type="OMA" id="KWSICAW"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="415" mass="45725" checksum="DC4C88B496E8E7F5" modified="2013-05-01" version="1">MDPVTQQWPNRRLEVLIPMWSMAVIATVFLVWRVVYGFSRSRRFMTSDYLLIVAGALNITATSLTQVITDNGLGRHIMDPTVLPNILKYSYYLWITQIVNIIAMAFLKWAICAWLLVLNFSKIYQVIIWLSILMVTALNFLAPVFTLFGCTPLEKNWNFGFKGESHCWAKGTLPQSYAQGISNVVTDVVYMAAPLIYLSHVQLSRRTQWGIRVVFLLSIPATICSIFKTIELKTIVSTRDPTWDGVPLTVWSGAELSLGITIASLPPLRKAFDHFFSKILPSTLTGSGRTKAYGYGGNSTIGGGAAGSNGIPLKNFQGSKAYHSRIPGESVLDDESDRAILTDEEEHKGPGIMKSMNVEVRVSEHGLPSGLHPASESSRSSGDAPPITKTFESPRIDWSSPHIESGSGGPGSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6A9</accession>
    <name>M2T6A9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_355903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699338.1">
        <property type="nucleotide sequence ID" value="XM_007701148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6A9"/>
    <dbReference type="GeneID" id="19138401"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355903"/>
    <dbReference type="HOGENOM" id="CLU_785286_0_0_1"/>
    <dbReference type="OMA" id="ACACMIS"/>
    <dbReference type="OrthoDB" id="3691648at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39399" checksum="AE907C4EDD2DD31B" modified="2013-05-01" version="1">MSSRATFSALALSHLAEIPCLHREGSSAVTRPDFEGHFAHAAFEPAKAFVPRSSLHDQIHAQLTRAATDNSTKTLVVWGLDGAGKTQLVLGYMYKHHVEYDATFWIEAGRKESLEGDFGKFGDDNPVTGVKSWFAGQQGRWLMVFDGANTIEDAEADGYIDIKHFIPSAAYLDVVITARRSRAKCMTHSEGVEVGEMEARQSVELFQKYACTPHVDATDRNEVMRIVKKLGCLALAVTLATTYVGSTPRLQSNIKEYLHEYRLRQQELLKRKSESLVHQCKDSVLKTCETSYAAVYNQCPEASVLMTILSFLSFDDMYVELFCPETEQGGVKQTDETGVSWKRLVSPKQPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6W1</accession>
    <name>M2T6W1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_217399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695264.1">
        <property type="nucleotide sequence ID" value="XM_007697074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6W1"/>
    <dbReference type="STRING" id="665912.M2T6W1"/>
    <dbReference type="GeneID" id="19134524"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_217399"/>
    <dbReference type="eggNOG" id="ENOG502RHRU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021538_0_0_1"/>
    <dbReference type="OMA" id="SHVMYKH"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD70135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61112" checksum="A0172A8AB70892F7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2T844</accession>
    <name>M2T844_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_180195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698573.1">
        <property type="nucleotide sequence ID" value="XM_007700383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T844"/>
    <dbReference type="STRING" id="665912.M2T844"/>
    <dbReference type="GeneID" id="19133235"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_180195"/>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014248_1_0_1"/>
    <dbReference type="OMA" id="AWTIVFK"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000149">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:clathrin-dependent endocytosis"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000025">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="609" mass="67063" checksum="637FDDCBDB7C4308" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8V5</accession>
    <name>M2T8V5_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_159311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698759.1">
        <property type="nucleotide sequence ID" value="XM_007700569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8V5"/>
    <dbReference type="STRING" id="665912.M2T8V5"/>
    <dbReference type="GeneID" id="19131952"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159311"/>
    <dbReference type="eggNOG" id="ENOG502SNJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067631_0_0_1"/>
    <dbReference type="OMA" id="PICNDYP"/>
    <dbReference type="OrthoDB" id="5377599at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="92"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="240" mass="26242" checksum="D305AE95425AAC2A" modified="2013-05-01" version="1">MKAGAPPKTPTTTTTTSASEAVEPSPVLRETVVTAPAVDTTPSTSPAFGPSSKTPSRRVLRLKCPVCSDYPDGFRSEHELRRHTNRVHKKVRKVWVTIDTSPDKSFLANCKACQTGKRYNECYNAASHLRRMHFHPHKRGERKMTAAEARRGGKPGDLDPPMDVLKANWLREVDEVLDDGNEPTEEDALNASLSPPQMVSPQSQQQSTSNKSDGQAPPTPTTPSTRSMAIDSIVDKVDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9I4</accession>
    <name>M2T9I4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_86986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698681.1">
        <property type="nucleotide sequence ID" value="XM_007700491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9I4"/>
    <dbReference type="STRING" id="665912.M2T9I4"/>
    <dbReference type="GeneID" id="19141152"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86986"/>
    <dbReference type="eggNOG" id="KOG2459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010026_3_1_1"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="568" mass="62479" checksum="B94E6336A9886A78" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="91"/>
        </location>
    </feature>
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            <end position="72"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="EMD66051.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="158" mass="18268" checksum="A41F97605EBFD367" modified="2013-05-01" version="1">MQPALPQSAILNEEMLPKSLKDEAKDVKKKEKEKKKKEEETTMENVKNDKEDYVTDNAEQPERSCQSSTAIVSQKDDAFVSDPALQPDGENVRVPKYLKDFANILRDTGEFHRVTMKNNVQTLQKNIQNTILNHEILPNPHIKIFRENIQKILRLANR</sequence>
</entry>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_007699344.1"/>
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    <dbReference type="STRING" id="665912.M2TC06"/>
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    <dbReference type="eggNOG" id="KOG0318">
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    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="8"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
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        <location>
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            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
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            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
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            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
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            <end position="564"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="573"/>
            <end position="607"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD66367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="607" mass="64409" checksum="8AB21E04899912DD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCZ5</accession>
    <name>M2TCZ5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_351853</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696852.1">
        <property type="nucleotide sequence ID" value="XM_007698662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCZ5"/>
    <dbReference type="GeneID" id="19138121"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_351853"/>
    <dbReference type="HOGENOM" id="CLU_730666_0_0_1"/>
    <dbReference type="OMA" id="VEWRCNG"/>
    <dbReference type="OrthoDB" id="3694693at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="413" mass="47074" checksum="8200EE3C739DBD27" modified="2013-05-01" version="1">MKMSLLTRPPPPSTHSFLSRPNTFTLPFPTGATLHFTLPLLPARLSPLRTPELTHLRTYLTSLLSSHTITSHQTLLAHILSLRRIISLRLSRSQQLTPVEQKAWYSGHGFPIFDSENRVTGFEWCWEALEFEFGVHVVAWVVRWLFKLQRRTAEERYAVRRSYRFMENEVSYRREKVEGHEVVEWRCNGEEVCVWVYGACFRDRQEWEFIRGELEGYEVGMLKEGVAKIRNTVRGGWEFMLYVEGEEAEVEELFLVERPASESLSDRSEDDDAESLDGYCYGDDVERLVALASGLGELAQSSCASSSDDHEEAVEQTLAVAPRFGDLLHQAETLVSAIKGINDKKQSSSSQHSQIPPALQTQPLPSQYAASTIRLPRCAATRQPRTLQRYQAYAEDDDGEDSITALPSSWRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEK6</accession>
    <name>M2TEK6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_351951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696902.1">
        <property type="nucleotide sequence ID" value="XM_007698712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEK6"/>
    <dbReference type="GeneID" id="19138128"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_351951"/>
    <dbReference type="HOGENOM" id="CLU_743953_0_0_1"/>
    <dbReference type="OrthoDB" id="3690541at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="372" mass="42102" checksum="DA8BBD0D543EECCF" modified="2013-05-01" version="1">MTEDVTKMLIAGIDALDLKQSTEETCVVRNSANKPLSGSVSQRPIAKFTRRIRIQHVDQSCGSSVDQTQSLGAKDEETTVGDISRLRKDSHFEITNNISTTRPPVVHSAQSKLQLLLLENEKLKKEADDSEAKWNEEISKRLEAESDLKEKEDELLACRKELESLKHQTQQLRSRTTTEQISLSETNFPTLTDISFSKAYRETDYSTRVTLNLTLSKIYTFPAKEWDKTGQPYESPDDGAIAITRLFGNLYASKCGPNPDLCTDFIDKDIWTREAILFSKMLGLPLEHRWAMHAEMQLITFWLTRYLGSAGFEMRDFDNPGAYKACPEVEGGVIRIFISQRVCGSCLGVVERVNWVVGKYGVEFEVVDRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2TG32</accession>
    <name>M2TG32_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_349590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695874.1">
        <property type="nucleotide sequence ID" value="XM_007697684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TG32"/>
    <dbReference type="STRING" id="665912.M2TG32"/>
    <dbReference type="GeneID" id="19137967"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_349590"/>
    <dbReference type="eggNOG" id="ENOG502S659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039562_0_0_1"/>
    <dbReference type="OMA" id="MVISEWG"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025915" evidence="1">
        <location>
            <begin position="18"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="422" mass="47796" checksum="81E1EB578249DA95" modified="2013-05-01" version="1">MFFCIIWGLLLGSLATAVPQHESKRAAPTLPLSTKGRDIIDAKGNVFHFMSTNWPGHQEIMIPEGLQHSSIEKIVSWFPKLGLNSVRMPFAIEMIDDYLANSPNQTLEKSVLRAIPGTNGTNVLSSILKNNPQFTKNTTRLQVWDAVAKELARQGIVLHLDNHVSKAFWCCGENDGNGWFGERYFDVEKWKRGLAFITKHASLRNELRSAKGAEPVDWYTWYIHMTSAANAVHQADPDALIFFSGLSYDTYIDPIPLGKTLSGTAGTSTANKKATFIPSDFAWKNKIVLEIHKYDFEGTKDNCQTFKRKWYQNGFQAVNASDPATKYVFPMVISEWGFINNGVYWNQTTYAKCLVEMVKEYKVGWQHWELCGSFYLQTRPNRQPNTLVGADEAWGILNYNWSAIRSPVTLENSLFKMIAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGI4</accession>
    <name>M2TGI4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartokinase</fullName>
            <ecNumber evidence="8">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_34622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="8"/>
    <dbReference type="EMBL" id="KB445639">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2TGI4"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_34622"/>
    <dbReference type="eggNOG" id="KOG0456">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="465"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="528" mass="57731" checksum="381BDC3C42DF03A4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI01</accession>
    <name>M2TI01_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">Cell wall protein PhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_187691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696348.1">
        <property type="nucleotide sequence ID" value="XM_007698158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TI01"/>
    <dbReference type="GeneID" id="19133598"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_187691"/>
    <dbReference type="eggNOG" id="ENOG502SNZ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097238_0_0_1"/>
    <dbReference type="OMA" id="CTRCEDN"/>
    <dbReference type="OrthoDB" id="4093325at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026768" description="Cell wall protein PhiA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="20883" checksum="67FEDEA8E760A42F" modified="2013-05-01" version="1">MKFTTAAIATSVAALAAASPLQTRADDTPLFWTSRLLAIAPGTDFDGKFLQAANSGLLIGLKDQGASCGPEPHNYATFVFGNNTLSLYTANPPQQFYTAADGMGQGNIRYTTGVEPLPRNALREGFFIDNHGTLKLQFSPTGPVAGLQACPVSNAPGEYKVWMDTFEHPAGQNCTKFQARVDNDWTPVKCKYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIB9</accession>
    <name>M2TIB9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_21255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694046.1">
        <property type="nucleotide sequence ID" value="XM_007695856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIB9"/>
    <dbReference type="GeneID" id="19134429"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_21255"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_0_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="346" mass="39046" checksum="A468D8B5284B1221" modified="2013-05-01" version="1">MVHEYQFKNTVYRIASLYENDVVVLQASFLPELRKLGQDVLSPYKMTEQVSSGYPDTTKAIAKSNQARMNDEVYRKMKDCVEPIIRQKQEAEQSDSAWQKPDDMLQWILTRSISSNAMETLHYVTKQQLLLTFAAIHTITMVTTNILYTLPAAPEYMLALREEISNVLAENGGVPTPKALQQMVKLDSFSICITRLNLLICVLGVFARSVLKPIILSNSQKKPSGGSVKVPSFQVFPGWDLNTNADEFNGFRYYKQWINASRPAEQARARFVSSHEDSLAWGYGKHACPGRFFAASEIKMPLIKFITDYDINMPDGRKEIYAQVGIGNLCAPDTTKELVSGRVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ55</accession>
    <name>M2TJ55_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_80231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696261.1">
        <property type="nucleotide sequence ID" value="XM_007698071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ55"/>
    <dbReference type="GeneID" id="19140775"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80231"/>
    <dbReference type="eggNOG" id="ENOG502QSNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024518_2_1_1"/>
    <dbReference type="OMA" id="TNEYEHN"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="70"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="462" mass="52669" checksum="B931964F7E9BD293" modified="2013-05-01" version="1">MIQAAKILEQRSHLIPGKLRITEHFFQVPRDYSNPSLGTIQLFARSALKAEKPADYTPTSHLEKAKTQLPWLIYLQGGPGFECHPPQNVSWTHTILDKGYQVLLLDQRGTGLSTAISQSSLQLRGDEKVQADYMKSFRADSIVKDCEAVRKALTADYPEEKKKWSIMGQSFGGFCCTTYLSFYPEGVKEAFLFGGLPPLRDNADEVYGRLYARVKSRNEGYYQKYPEDVERVKRIVKLLSRFGDTTVRVQGGEGHLSARRFLQLGIYFGKHGGFDDVHNFVLRADTDLTQFGHLTRPTVLALEAAQSWDTNVIYALLHEPIYCQGQAANWSAERMLDEHPEFSLSRVDSKDPIYFTGEMIYPFMFDCYPELKKLKKVGELLAAEKDWPKLYDVEQLKKNEVPTYAAVYMDDMYVDFNLSMETASTIKGCKPFITNMMYHNGIGAKTDEVLKQIFSLRDDVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLY4</accession>
    <name>M2TLY4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_32377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694278.1">
        <property type="nucleotide sequence ID" value="XM_007696088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLY4"/>
    <dbReference type="GeneID" id="19136750"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32377"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="TWGLFVM"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF52">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11820)-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="226"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="387"/>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="14"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54195" checksum="49CF457B569B2CEE" modified="2013-05-01" version="1">MAEPSSIEKGAYVQGSSVSSPGSTTEEVSFDPAAERKLLRKLDIRILPVLWILYLVNFIDRANIGNAKIAGMEKELNLIGQRFNICVWVFNLGYLVAGIPLQIAFKHYGPKSLCVMMFFWGITVIGQGNVKRWEEMVVCRLLTGFAEAAFISGCAYLIGAYYSKREYLTRYVYFLTAGIIAGAINGFLSSLISKMSGTAGYAAWRWIFIIEGCITVFISIITWPFIPPFPEDCNFLTPDEKALMLARVKADGGHVSDDEITLKKALEYLKDWKIWTGVAMNLGVTENANSLANFQPTILKGLGYTAIQAQVHTIPVYLVGAAFSVIFAYASERLQRRYLFYIFGWAVLAIGLIVEIAHPPNPKVRYMGMFFIACGCYLAMPISIIWVSMNCGSGYKRAVAIAAIINFGTAGAFVSSNVFLFKEAPRFRTGFSTGLGLACMGAIAATITWYGCKKENKKRDQKRLELPEVLDQSMKELGDEHPDFRFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_156124"/>
    <dbReference type="HOGENOM" id="CLU_2454381_0_0_1"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EMD69987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="83" mass="8581" checksum="683DE3428FCC1CEB" modified="2013-05-01" version="1">MGRAGYDTTYVCTTTDSAATTAIAMADAQRTKDAKTAEQQASAANEAKLIKNKHSRGIVAARLAMQEKTTSAAAKKQSGSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2TMR3</accession>
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        <recommendedName>
            <fullName evidence="5">Heterokaryon incompatibility domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_342117</name>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TMR3"/>
    <dbReference type="GeneID" id="19137520"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_342117"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_4_1"/>
    <dbReference type="OMA" id="HGKREKW"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="276"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD70002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="76598" checksum="6385D547DA9C8286" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSF4</accession>
    <name>M2QSF4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_42101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445714">
        <property type="protein sequence ID" value="EMD58119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706180.1">
        <property type="nucleotide sequence ID" value="XM_007707990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSF4"/>
    <dbReference type="GeneID" id="19140165"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_42101"/>
    <dbReference type="HOGENOM" id="CLU_013929_6_0_1"/>
    <dbReference type="OMA" id="QRDHEES"/>
    <dbReference type="OrthoDB" id="3795213at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="254" mass="28632" checksum="04801E7A66F2D231" modified="2013-05-01" version="1" fragment="single">AWCAACKELSILHAFRATGLSPFNPEVILQEFKTTAANSDRGALVASASDWRTIRQLLNQSTSNRSISALNRIMMKLSADTTFLQRENEQLRAALMDEKQWKERIQPGTLELSDGYHGGATFWSPRKKQRDHEESQRQKAITIEARKERKLLKAQELDERRRARAQAKLDRERQKAEAAAHRIARQAAHKRLQKAIKISRIGKKPSSKRHARLVLKNIIVSSSSGGAQPADRSAAPPSPRSCSGRPIKLPIKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSK9</accession>
    <name>M2QSK9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_71043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445679">
        <property type="protein sequence ID" value="EMD58169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706132.1">
        <property type="nucleotide sequence ID" value="XM_007707942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSK9"/>
    <dbReference type="STRING" id="665912.M2QSK9"/>
    <dbReference type="GeneID" id="19140474"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_71043"/>
    <dbReference type="HOGENOM" id="CLU_000680_30_6_1"/>
    <dbReference type="OMA" id="VTTRWIP"/>
    <dbReference type="OrthoDB" id="3695143at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="80" mass="8836" checksum="415F6662B31DD076" modified="2013-05-01" version="1" fragment="single">LYYDHANEHSERKSIAIYTDKQAAIWSIVEAEGRSGAYILGKIAQQIQELQDKGLTVTTRWIPAHVGIPGNEAADQAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSR2</accession>
    <name>M2QSR2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_104334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445660">
        <property type="protein sequence ID" value="EMD58219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706071.1">
        <property type="nucleotide sequence ID" value="XM_007707881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSR2"/>
    <dbReference type="STRING" id="665912.M2QSR2"/>
    <dbReference type="GeneID" id="19129903"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104334"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_45_3_1"/>
    <dbReference type="OMA" id="HFSVAAY"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="118" mass="12835" checksum="B2302587AD85D97D" modified="2013-05-01" version="1" fragment="single">KVDPDAKDKNGWTPLIWAIQNGHEAVVKQLLDIGKADPDAKDENGWAPLFWAAQKGHQAIAKQLLDTGKVDPNAKDKNGLTLLLLAAQDGHEAMVKQLLDIGKVDPNAKDKNGWTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2QWP1</accession>
    <name>M2QWP1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_250797</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704556.1">
        <property type="nucleotide sequence ID" value="XM_007706366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QWP1"/>
    <dbReference type="STRING" id="665912.M2QWP1"/>
    <dbReference type="GeneID" id="19135210"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_250797"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OMA" id="FETWYAM"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD59509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="358" mass="38666" checksum="A8D0352C08E4EA6A" modified="2013-05-01" version="1">MATQTASQKNPSFVLQEPFKVTYEDRPIPELPSPYDVIVRPRWTGICGSDVHYWVEGRIGHFVVEKPMVLGHESAGIVHKVGDKVKGLKVGDEVAMEPGVPCRRCVRCKEGKYNLCPDMAFAATPPYDGTLARYYTLPEDYCYKLPGNMSMEEGALIEPTAVAVHITRQAAIKPGDSVVVFGAGPVGLLCCAVAKAYGAKKIVTVDINDERLDFALNYAANASFKSERVSAEENARNMIKQCELGPGADVIIDASGAEPCIQTAIHALRMGGTYVQGGMGKPDITFPIVAMCTKELNVKGSFRYGPGDYQTAIDLVATGRISVKELITGKVKFEDAENAFKDVKGGKGIKILIEGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZ17</accession>
    <name>M2QZ17_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_151759</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704442.1">
        <property type="nucleotide sequence ID" value="XM_007706252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZ17"/>
    <dbReference type="GeneID" id="19131567"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_151759"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OMA" id="WGAKTGM"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    <sequence length="92" mass="8876" checksum="73366358BA677A3F" modified="2013-05-01" version="1">MAEQNEQQQQKGFFGTAASGLGNTLGAATNTVGKGVQGITDTTGNVVSAGGKGLGDAVTGVTSGVGETTKAAGKFVGDTTQAGGKSVQGEKK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD62529.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="210" mass="24050" checksum="DC382362C54A1130" modified="2013-05-01" version="1">MTQNSKRALTASAYQQLAPPTYYRTGPYPPNVSHEVQISQLRHAPQPLITGIPAGIRTGAQITTRDDRAISKTWHDEWETEPRPFGPRRPLALLNQSVQINLQTHPRNAKRVYLNHWDRQHEPNGTTAQRLVIQERQVRMERRTMILRAEQQEERRREVKQAAMNADVVDLTGDGISDEKGPWRHDSVGHAGLPGSSGETIHTWDHSWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701274.1">
        <property type="nucleotide sequence ID" value="XM_007703084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R7P2"/>
    <dbReference type="STRING" id="665912.M2R7P2"/>
    <dbReference type="GeneID" id="19137240"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_336382"/>
    <dbReference type="eggNOG" id="KOG3844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017005_0_0_1"/>
    <dbReference type="OMA" id="GWYHIPQ"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="136"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="490"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD62999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="657" mass="74240" checksum="6CDB401BFD21A9E9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8A5</accession>
    <name>M2R8A5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_172578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701394.1">
        <property type="nucleotide sequence ID" value="XM_007703204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R8A5"/>
    <dbReference type="STRING" id="665912.M2R8A5"/>
    <dbReference type="GeneID" id="19132798"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_172578"/>
    <dbReference type="eggNOG" id="KOG4680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097982_0_0_1"/>
    <dbReference type="OMA" id="HQTYDLC"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023668" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD63164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="167" mass="18215" checksum="B304A9AB954F5BAC" modified="2013-05-01" version="1">MQLTTLFVAALSAVSVSASPSWMGGDQVVVKEEYKVPGENPLYFCGDPANDILTIEKVDLSPNPPQPGQTLSIKATGNFKEEVGEGFKMHLQVKYGIITLINQNADGCDTIKKGDLDCPLKKGEMSLTKDVDLPREIPPGQYTVLADVFTENEEKITCLTAKIAFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8U2</accession>
    <name>M2R8U2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_359697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703349.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19138631"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_359697"/>
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    <dbReference type="OrthoDB" id="3696837at2759"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="54" mass="6547" checksum="091BBBE5D5C8ED56" modified="2013-05-01" version="1">MRELHEELSIRIYPIFYKKLLELAPLDTKLVIDIELKDDEYKIEEIKNLRKISS</sequence>
</entry>
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    <accession>M2RAE6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700464.1">
        <property type="nucleotide sequence ID" value="XM_007702274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RAE6"/>
    <dbReference type="GeneID" id="19139024"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37602"/>
    <dbReference type="eggNOG" id="ENOG502T036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712942_0_0_1"/>
    <dbReference type="OMA" id="WLFNGYS"/>
    <dbReference type="OrthoDB" id="5089392at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="159" mass="17195" checksum="D9D506E9440E4731" modified="2013-05-01" version="1">MASHTQTMPLPIRTNTVDSQKSRSSSSGQISPPYSPASPTSRMATSPTEESFFGAITARICGRSRSRSRGAPSDKRPRSPPMAMPPVQPPHLRHASTASSTISPGPVATPGHSIRPTIQDVGRRTTSGSDPWRGRHSNDWLFNGYSVTASAKDFLQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RD65</accession>
    <name>M2RD65_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">COCSADRAFT_36131</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699106.1">
        <property type="nucleotide sequence ID" value="XM_007700916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RD65"/>
    <dbReference type="GeneID" id="19138669"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36131"/>
    <dbReference type="eggNOG" id="ENOG502SDB7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_0_1_1"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="182" mass="20109" checksum="A9085A7665688219" modified="2013-05-01" version="1">MSLFRTTLLQRQLFAPARITCIRYASTSTPENIVLPRLQTDLKIAMRSKNKPALNTIRGLQAEIINASKTAKPITTDGALYSLVQKQIKASSASIEEFRNAKREDLVEKEQQNLDILKAYADEIPTVSESEVDSLVKSVVEGLEEGKRNFGSVMGKIMGAVKGRPLDVEYVTKKIQEAVGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2RG19</accession>
    <name>M2RG19_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase Rpb6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_87368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD65704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19141182"/>
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    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_0_1_1"/>
    <dbReference type="OMA" id="ADYWDPE"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
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        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
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    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD65704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13511" checksum="7672EF9EFBEE042E" modified="2013-05-01" version="1">MGGGEDPDNADPNDDNVVVSGDASAAAAAREAAKNTVTSEKDKKVPNDKRTTTPYMTKYEKARVLGTRALQISGNAPVLIDVEGMTDPLQIAAKELQEKKIPLVVRRYLPDGFYEDWTCEELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RG43</accession>
    <name>M2RG43_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_309077</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RG43"/>
    <dbReference type="GeneID" id="19136339"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_309077"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057148_1_0_1"/>
    <dbReference type="OMA" id="LHVWAKE"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="274" mass="30878" checksum="9A63B6BBEF4DF718" modified="2013-05-01" version="1">MSGPYLHGHHASVLRSHSWRTVENSCPHLLPFLNKPSLKILDVGCGPGTISVDLAARVPQGFVYAIDPSANVIEKARKHAEEMGIKNIRFEVGDIFEWNKLEGVEEQGFDVVHAHQVLQHLQDPLGAMKEMKRLAKTGGILAIRDCNYGAMDWYPDHPMLHKWKKLYIKVALGLKAHPNIGKQLHAIAMEAGFPRSDIEASVAAWTFSTPEEREFWCGLWADRTVQSDYKKRALDSGHATEQDLEEISAAFREMEKKEDGWLVVINGQIICHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2RH66</accession>
    <name>M2RH66_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_34668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_34668"/>
    <dbReference type="HOGENOM" id="CLU_3068542_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="53" mass="6175" checksum="79BF1F3C925582AE" modified="2013-05-01" version="1">MRSEQNASIHFSSFYGIPRAFILYSSLFLHTPLYAPLTSKLIRLTIRRPRHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2RLH0</accession>
    <name>M2RLH0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_179141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698945.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2RLH0"/>
    <dbReference type="GeneID" id="19133182"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_179141"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="OMA" id="QYEGTML"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="88"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="399"/>
            <end position="618"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="620" mass="69192" checksum="F0D3AB025FCE786D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQ44</accession>
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            <fullName evidence="4">MARVEL domain-containing protein</fullName>
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    </protein>
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    <organism evidence="2 3">
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696232.1">
        <property type="nucleotide sequence ID" value="XM_007698042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQ44"/>
    <dbReference type="STRING" id="665912.M2RQ44"/>
    <dbReference type="GeneID" id="19135701"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_275649"/>
    <dbReference type="eggNOG" id="ENOG502S71G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108574_0_0_1"/>
    <dbReference type="OMA" id="WMMVMAS"/>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20965" checksum="58AFB0D423C74915" modified="2013-05-01" version="1">MARAGHSGTVVGSAIVVREKYYWPDLQLNIWTIVMLATAGLILGVNAQFMDIQNRMGLGTPWIMPYGVTVGTLAIIFIIIEIIYIAQRKLLPSVMMLFSFILLVLFLAGVIGTAIQLFAGPNINNQCNTYVFNNDARGPTMETLAFLQQRNICQCWQAQFAFWIIGTVFLVWMMVMASQVNSNTYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQF1</accession>
    <name>M2RQF1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_134972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696316.1">
        <property type="nucleotide sequence ID" value="XM_007698126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQF1"/>
    <dbReference type="STRING" id="665912.M2RQF1"/>
    <dbReference type="GeneID" id="19130947"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134972"/>
    <dbReference type="eggNOG" id="ENOG502S5V1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024412_1_1_1"/>
    <dbReference type="OMA" id="MPWNAQL"/>
    <dbReference type="OrthoDB" id="2440523at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF2">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="293" mass="33371" checksum="D0B92C36662BE1FA" modified="2013-05-01" version="1">MPQSRPKPSEIAAEAKRVWMPHIWKHYIRDSKTSYLYPDSAQIRVNVDKRSSQRTRVAVMEGDPINYALGWYQSALNADPNCKRIPVVNVANEKRAGGDWESGLMAPEECFARRSNLVHALTMPWNAQLGVEENFYPIPQRGGIYSPEVYVFRAGPEQDYAPFSDMASLPVISVAPVRRPKLDESGCKYSFAQERELMREKMRAVLRIASYCGHRNLVLGAFGLGPIFRNPAQEVACMWRQLLFEEEEFHGAFQDIVFAIDSSMVGSPSKGCMSDVDIFRREFDPATIWPTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUF1</accession>
    <name>M2RUF1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_41356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705210.1">
        <property type="nucleotide sequence ID" value="XM_007707020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUF1"/>
    <dbReference type="STRING" id="665912.M2RUF1"/>
    <dbReference type="GeneID" id="19139971"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41356"/>
    <dbReference type="eggNOG" id="ENOG502S2MG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028361_0_0_1"/>
    <dbReference type="OMA" id="WQGVDNS"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39563" checksum="2098F356B91C5C33" modified="2013-05-01" version="1">MADQPISLVDHTNGDNTPSTTVTQSEQQLTNASSHIDILYENQRGWFVFGIPLFSSKALWNLRIDPAPWQDAKFKPSAVNITNAQVPDPSWVWDWKTWYVDMSLDVDEEGWQYNFFFNGSAWHGNHPWFHSFVRRRRWLRRRVKQRLPPKTRANAKERMFGEQFSIGTTLARSTTFGTGSGLLDSSQTSLDEEIRDIATLMRKLKAAAIDREKIVYIHKFINDGGEELHYLAEQIPTIMSMLIFQNSRHQLLSTLMDRFDAAKEHREQHEKDGKPEDEAEERRINNLLKAVEAADNECKKLEYWSDIKNLTEEGKAGNATDPGMGWDEKWQGLDVSGASYPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXV1</accession>
    <name>M2RXV1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704059.1">
        <property type="nucleotide sequence ID" value="XM_007705869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXV1"/>
    <dbReference type="STRING" id="665912.M2RXV1"/>
    <dbReference type="GeneID" id="19139714"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40367"/>
    <dbReference type="eggNOG" id="KOG4555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074601_0_0_1"/>
    <dbReference type="OMA" id="ILYKAAR"/>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="238" mass="26319" checksum="45870EC1752B0B3C" modified="2013-05-01" version="1">MAANMPNTRLSANDARILNALFDPETLPSSVAKSRDNAAIDKSMPPDPRISASQLSELEKQQNDIIRNVSSNSDKTTIDDAITQLNKTLVACPYYASAHVNRAMLRRMRIEASLTEGQTIFSTTTHDIEDLFYDLSRAIHLSLPASSPADPVSEYAARILRTAYSHRAYLYLKAVEAETLLNGLSKSELEELASKDFAQAARYGDEVAREMSVRTNPYAKMCGAIVRNALQEEMKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2S3T6</accession>
    <name>M2S3T6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_38655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702082.1">
        <property type="nucleotide sequence ID" value="XM_007703892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S3T6"/>
    <dbReference type="STRING" id="665912.M2S3T6"/>
    <dbReference type="GeneID" id="19139309"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38655"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_0_0_1"/>
    <dbReference type="OMA" id="HYEADIY"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="7">
        <location>
            <begin position="751"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD61853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115943" checksum="3D46CB98317571D6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2S5C4</accession>
    <name>M2S5C4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_38316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701588.1">
        <property type="nucleotide sequence ID" value="XM_007703398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S5C4"/>
    <dbReference type="STRING" id="665912.M2S5C4"/>
    <dbReference type="GeneID" id="19139222"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38316"/>
    <dbReference type="eggNOG" id="ENOG502QV0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003608_0_0_1"/>
    <dbReference type="OMA" id="LWVTVKP"/>
    <dbReference type="OrthoDB" id="47488at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04486">
        <property type="entry name" value="YhcR_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024679" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="303"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="612" mass="66094" checksum="EDCAF8D3A6516306" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6Y2</accession>
    <name>M2S6Y2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_165888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ND90Pr / ATCC 201652</strain>
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        <property type="entry name" value="tRNA_TruD_broad"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
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    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="19138927"/>
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    <dbReference type="HOGENOM" id="CLU_2996219_0_0_1"/>
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    <dbReference type="OrthoDB" id="3693782at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PROSITE" id="PS51257">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025325" evidence="1">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="62" mass="6504" checksum="216D8BD92669ABB3" modified="2013-05-01" version="1">MKYFTLVTITTIVAFATAHPAAQGIGQSVVACSRICAGPSLSCSGDEFVQHTGDCYTCCRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2S860</accession>
    <name>M2S860_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_30935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705185.1">
        <property type="nucleotide sequence ID" value="XM_007706995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S860"/>
    <dbReference type="STRING" id="665912.M2S860"/>
    <dbReference type="GeneID" id="19136345"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_30935"/>
    <dbReference type="eggNOG" id="KOG1487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="290"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40229" checksum="336067F1CB512E82" modified="2013-05-01" version="1">MSTTVDKIKEIEAEMAKTQKNKATSFHLGQLKAKLAKLKRELLEPSSSGGGGGIGFDVARTGVASVGFIGFPSVGKSTLMSKLTGQHSEAAAYEFTTLTTVPGQVMYNGAKIQILDLPGIIQGAKDGKGRGRQVIAVAKTCHLIFIVLDVNKPLTDKRVIENELEGFGIRINKSPPNIVLKKKDKGGINITATVPLTHIDHGEIKAVLNEYRMANADVAIRCDATVDDLIDVIEAKSRSYIPVIYALNKIDAISIEELDLLYRIPNACPISSEHGWNIDELLEQMWEKLNLVRVYTKPKGKMPDYSAPVVLRSTACTIEDFCNSIHKTIVDNFKHAIVYGKSCKHQPQRVGLSHELADEDIVTIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2S907</accession>
    <name>M2S907_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_358353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700834.1">
        <property type="nucleotide sequence ID" value="XM_007702644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S907"/>
    <dbReference type="STRING" id="665912.M2S907"/>
    <dbReference type="GeneID" id="19138554"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_358353"/>
    <dbReference type="eggNOG" id="ENOG502SRU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959716_0_0_1"/>
    <dbReference type="OMA" id="YQTHEYE"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="310" mass="34903" checksum="277592EA0938CE36" modified="2013-05-01" version="1">MAAALPIALYDLHSGIYIPPVGPARVVATVRQKTISRLKRLFPQLFALSNPGPPNLSLEIILMIAEYFDKCTLRLECKKDPDRRFCFPFCGYIPYHHMRLVMNRHFYGPEHGLPLQALSERQNYQTHEYEVECSISQHARIFGDELLVLTVISMTQLRGDLVLLRSHVESFGGSVCQHLTISQRSPVCIPIQFPELAKKGNASGSFPACGPMYGSCTSCLTYYSINITWQGLEKGYSIEVLVYRGLGDCRTPESWYWRTMARWDPSEKSRSAYSPHNPPGSIRDRWDEAGGVAEITDGAWRRASRAAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCB0</accession>
    <name>M2SCB0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_164237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="279" mass="31704" checksum="EBB5C1719D9A2308" modified="2013-05-01" version="1">MTVHLWLPCQWSPSFLPYSYFIRELSTSTFNHGFSYNPFSSLDSFLAIFLTLATNIETINLTATRAEPLANCREILGISWFDYPVDATQQEQQPFAKLSDLCIAEIKPQGIEAGHTFCMSVMPSVKCLRLPGWGIDGIDLHHDTPLALQHLDLRDVAVSPVHVMRCFFLGQFANLRHLTLDGTQDLRHRLNDLSWFCGTFDYKVLGRRLVQYTPLLEVLEMRMKKDSTITWPFSIGSLVGLTKLHTLRISIDHLVFADGLLNPDPVDPHQILPASLRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFT9</accession>
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            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD61305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3998">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Surf1/Surf4"/>
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        <property type="entry name" value="Surf4"/>
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        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
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    </dbReference>
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        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="214"/>
            <end position="231"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="254"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD61305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34252" checksum="3B5871F0504EAD6F" modified="2013-05-01" version="1">MAQIRGTAGYHLGNQSPFGNSGRNDDMNNDPSPLDQLRAQTSKLEDMLDTVADPIKPYLPAIGRFLIVVTFLEDALRIVTQWRDQLTYLHDYRHIPNGLTHMFLIVNVIAMTVCSIGVIARKYSEYSVGGLMGVVVLQGLGYGLVFDLNFFLRNLSVVGGLLMVLSDSWVRKKFAPAGLPQLDEKDKKMYFQLAGRVLLIFLFVGFVFRGDWGLWRIIASILGFIACVMVVVGFKAKFSAVMLVLILSIFNLYVNNWWTLHPHHPHKDFAKYDFFQILSIVGGLLLLVNMGPGQFSVDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGA3</accession>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66278.1"/>
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    <dbReference type="GeneID" id="19136095"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_296672"/>
    <dbReference type="HOGENOM" id="CLU_2223059_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025397" evidence="2">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="106" mass="11771" checksum="1F22489D0E9C59EE" modified="2013-05-01" version="1">MANSIFVILPIVILLEGLFYVEEGIPLSLSHEIASRQVTHLSLIPVVWGPDREDATPHTPTFSPDNPRALMHSPRDPPSLTRCLTTRNPNKTVNSPESTYHESFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGE9</accession>
    <name>M2SGE9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_123224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702832.1">
        <property type="nucleotide sequence ID" value="XM_007704642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SGE9"/>
    <dbReference type="STRING" id="665912.M2SGE9"/>
    <dbReference type="GeneID" id="19130550"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_123224"/>
    <dbReference type="eggNOG" id="ENOG502QTX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_1_1"/>
    <dbReference type="OMA" id="YCASPIA"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF7">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="73"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="385" mass="42609" checksum="D724B759373C4B3C" modified="2013-05-01" version="1">MHRLGLLEELRQYCVNETGMELVDLHGKSLMRFGVTKAGDKGGTFELTNEFEFMRGDFVKMMYTASLKDRDTLTAKGHTRGSITYLFNTTLTAISQDTTPDLATATFSTGQTTPYNLIVAADGQNSRTRRLVFGEAINTSAYTSLNTHAAFFPIPRSPRETSLARMYFSPENRLTMTRSGDRSETQVYLIQMQNPQRTPVLKAAQKLPVREQKEVWAELYRDAGWDCERFTQKLAGVEDFYATEIVQVKMPGKQLYSGRVVLLGDAGYCASPFTGMGTTLALIGAYVLVGELGGHGNDVGAALRAYEEEMKQPIEENQELGVLVNGGKGVFPRSAWGLWVVNTVLWTMSVLRLDKVLGMLAGLMPEGKGSGWKLPEYSGMNVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGT6</accession>
    <name>M2SGT6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_353738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697931.1">
        <property type="nucleotide sequence ID" value="XM_007699741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SGT6"/>
    <dbReference type="GeneID" id="19138255"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_353738"/>
    <dbReference type="HOGENOM" id="CLU_211836_0_0_1"/>
    <dbReference type="OrthoDB" id="3696837at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="54" mass="6540" checksum="DED6942C7B6571F2" modified="2013-05-01" version="1">MRELHEELNIRIYSIFYKKLLELAPLDTELVTDIELKDDKYEVEEIKDLRKISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIE7</accession>
    <name>M2SIE7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">COCSADRAFT_122493</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702437.1">
        <property type="nucleotide sequence ID" value="XM_007704247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SIE7"/>
    <dbReference type="STRING" id="665912.M2SIE7"/>
    <dbReference type="GeneID" id="19130525"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_122493"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0042555">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="RHEA"/>
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        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="term" value="P:double-strand break repair via break-induced replication"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCM_N"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="393"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD62130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="809" mass="90001" checksum="DBC07D958FC198DA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJQ1</accession>
    <name>M2SJQ1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_289092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJQ1"/>
    <dbReference type="GeneID" id="19135947"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_289092"/>
    <dbReference type="HOGENOM" id="CLU_185444_0_0_1"/>
    <dbReference type="OrthoDB" id="10334605at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025063" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10736" checksum="F240162540DC65C1" modified="2013-05-01" version="1">MIEWMCLFYWLLVLITSRHYRIKSGRDDIHGANIAHKYLGSPTCVLSRGESEFEHWVHGAAHQPFTQATGCPNRVSGGMVNAHYGKPIAFLQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SK97</accession>
    <name>M2SK97_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_94688</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702036.1">
        <property type="nucleotide sequence ID" value="XM_007703846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SK97"/>
    <dbReference type="STRING" id="665912.M2SK97"/>
    <dbReference type="GeneID" id="19141576"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_94688"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_1_1"/>
    <dbReference type="OMA" id="WASAYEQ"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025531" description="beta-glucosidase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="15">
        <location>
            <begin position="755"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD62745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="832" mass="90083" checksum="68F6E64F7273BEEA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKE3</accession>
    <name>M2SKE3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_188322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697243.1">
        <property type="nucleotide sequence ID" value="XM_007699053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKE3"/>
    <dbReference type="GeneID" id="19133623"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_188322"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="OMA" id="IANTAYC"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28020" checksum="40C6BDB9FA5CBCA2" modified="2013-05-01" version="1">MSQRTPDMTLASTFTRTSHAHPTPTTNSPPGLIILIIGASHSISAVIVKAYVLAGASTLILAARPSSATELSSVSQRILSSCTKSSTPAPTIHLEQVDISSSSSVSSLAQRISSKLPNLDIVILNSGLTGPLVLHVDKGDPQDFSNVLDAIVKGTYHVAQYFIPLLKANEGGKKMFIAVGLIAACITEGPFASTAYCLAKLAQARLVEFLAEQYKGEGVLAVAVHPGAVNTKMASVATPESLRAFLSDDVELCGAFCVWLSREKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKT0</accession>
    <name>M2SKT0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_293213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_293213"/>
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        </source>
    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="2">ND90Pr</strain>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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    <feature type="non-terminal residue" evidence="2">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66091.1"/>
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    </evidence>
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        <source>
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    <sequence length="55" mass="6200" checksum="48260CE29666045E" modified="2013-05-01" version="1" fragment="single">MGLHEPMPNPEPSNAPPRPPTYEELAESWSQLNATNNLLRRNLDQMATRLKDAEG</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    <sequence length="298" mass="34851" checksum="77EC6A322B48DA7B" modified="2013-05-01" version="1">MTTKDGTFEDSFARRMPLEIKQMVFKWAVSNNDNNDEDDNITDIEVELAHDNKQSLKSPALDLLATLAKWYLADVYKEAALYLTIQSFRWVFISNSEPYHSLLSVFYKKVPFDIRKRIKHVYLRKLRVLMPQVSNYSEYLRRIDEDGSHSRLKIFRALLKDIPEGIDLLSLMLPSIKKLDIGLDVCDLLLDFRAVAPALYEIVDELRKDPNAFSSYTAYLAIVYPLIFLKNISKISMRIVWDEHFEQKTDFEQEPDPYGTDKGEQELRELLFDLLRKDSYELCSEVDTRDLVGWIVSI</sequence>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMW9</accession>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ND90Pr</strain>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445726">
        <property type="protein sequence ID" value="EMD58107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698406.1">
        <property type="nucleotide sequence ID" value="XM_007700216.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706192.1">
        <property type="nucleotide sequence ID" value="XM_007708002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMW9"/>
    <dbReference type="GeneID" id="19138543"/>
    <dbReference type="GeneID" id="19140166"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35822"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_42107"/>
    <dbReference type="HOGENOM" id="CLU_1896036_0_0_1"/>
    <dbReference type="OrthoDB" id="3807107at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="134" mass="15339" checksum="31CA2F8312D14051" modified="2013-05-01" version="1">MSANKDPLQPRLRQLAAKFDSCLHNAQLSDIELLELYHSINIHDKIAKEAAMPEPNLRHLVVLCNMNDAITLGQYQLYQKRARAHDVTMYSASLLQASSDYEKECLKASDRFSIASRQCDKSLQSRIHNIHLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN68</accession>
    <name>M2SN68_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_274203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696152.1">
        <property type="nucleotide sequence ID" value="XM_007697962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN68"/>
    <dbReference type="GeneID" id="19135674"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_274203"/>
    <dbReference type="HOGENOM" id="CLU_2605881_0_0_1"/>
    <dbReference type="OrthoDB" id="3689690at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="79" mass="8897" checksum="36FDCFA1C22DD0A6" modified="2013-05-01" version="1">MEANNDRKLGYSVFCSFCLGALPIVHYRRGQSFRVRLVSIMCLMLIFVVAQSTTEPKDLAVQHNDIFRRAYGGPNSALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNA0</accession>
    <name>M2SNA0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_176750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KB445658">
        <property type="protein sequence ID" value="EMD58267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706028.1">
        <property type="nucleotide sequence ID" value="XM_007707838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNA0"/>
    <dbReference type="STRING" id="665912.M2SNA0"/>
    <dbReference type="GeneID" id="19133048"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_176750"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OMA" id="GLNRGYY"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD58267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="497" mass="54872" checksum="9CD6B29108337730" modified="2013-05-01" version="1">MSIPQHGNSSSRPSISFDLNRYPIPSKLFIDGRWTTSKSNNTQSYASAVNDQVICEDFQWAGKDDVEDAVESAATGLKKWQSLSKAERRDALLRYGKLVREHAEQIFWLEAILVGKTRKFSMFEIDHAVEALTYFAGLTFALDSRVVEREEDHVQYMIRQPYGICAVVLPFNGPLVCYCMKVAAALAAGNAVVVKASELNPFSTLFAVSLATEAGIPPGVINCVTGDGSVGRALAEHMKIRKISFTGSLAVGREVQIAAARSNLKNVTLQLSGKSPIIVFPDADLDKAARHCGMFLALNGQGCTLGTRVYLHKSIFKEMLPKIESLVQSYDDNLGSDPLKADTWSSPLFHHRQRERVLQYIEQGKKEATLLRGGEPIQGPGCFLRPAIFVDPLPDARILREEIFGPVLVVLPFEDDDEILRLANDTEYGLRAYVWTKDLGRAFRFTNLLEAGCVGVNEGPWSLHTTYGGWKQSGVGLENGEAGLLDWVQTKSVMIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNR4</accession>
    <name>M2SNR4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_128298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Salamov A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
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        <property type="entry name" value="Small_GTPase"/>
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            <begin position="137"/>
            <end position="158"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    <sequence length="243" mass="26073" checksum="A03862DD27571354" modified="2013-05-01" version="1">MADTSAQPKPSSSVKLVLLGEAAVGKSSLVMRFVNNDFQENKEPTIGAAFLTQKCNLPSRTIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDITKPSSLTKAQHWVAELHRQASPGIVIALVGNKFDLATAGDEDRPEDTDAAPAAEGEEEQAQDDQDSRRVPSKAAKAYADEESLLFFETSAKTGHNVAEVFTAIANAIPEASLKGPRHVGGQTNLARQDADRVNLGSAQPQGPKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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    <dbReference type="HOGENOM" id="CLU_2203168_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000016934">
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    </dbReference>
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            <begin position="20"/>
            <end position="44"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="123" mass="13340" checksum="49235BF25660EF6F" modified="2013-05-01" version="1">MQLMPGGHVGCHRRCRSTPQTAVADDMPPPIHTPQAPHLPTFPGADPPSRSCLLQCHTAHIYLLCSSPVQSNPVFSLMTPQTHAASKAEDASVHRRSLTPTALALPSPSFAFTLVRPQYMYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQA0</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="186" mass="20370" checksum="A667F8CD15B5C3A7" modified="2013-05-01" version="1">MLGNGRATTRQRQGKPRAAAVGCPCHCASRRPQSRHCVASAGPAHPPRHANHGMPLRRGRPAMHASDPRQPTTWLSAEAHPANRAKPRPLPACPHGSSRPRIVCHGGSGSGRRFPGLQMRCDATGQQNRHGHIRPHPLSRPFPPPSQHEPRLSRPVPPAFLLHASRLMPVCRPDKLCIATLWFQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQQ5</accession>
    <name>M2SQQ5_COCSN</name>
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        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
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    </protein>
    <gene>
        <name evidence="11" type="primary">PIM1</name>
        <name evidence="18" type="ORF">COCSADRAFT_115426</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699228.1">
        <property type="nucleotide sequence ID" value="XM_007701038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQQ5"/>
    <dbReference type="STRING" id="665912.M2SQQ5"/>
    <dbReference type="GeneID" id="19130282"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_115426"/>
    <dbReference type="eggNOG" id="KOG2004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_1_0_1"/>
    <dbReference type="OMA" id="WLTNIPW"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000113">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000002">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="17">
        <location>
            <begin position="162"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="16">
        <location>
            <begin position="871"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="261"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="804"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1068"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="395"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="814"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1088"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="963"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1006"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="582"/>
            <end position="589"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD64605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121391" checksum="A551C093DB9048BB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR19</accession>
    <name>M2SR19_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_159747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD60012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="361" mass="39958" checksum="B839B54F8477E551" modified="2013-05-01" version="1">MSLPTAPLGRNGPQVNRLGFGLMGLSMSYGPPKPDNERLALLDQAYELGERFWDSSDLYGDNEDLLGKWFKANPSKRADIFLATKFAIKNGGAEIDSSPEYVKVACEKSLERLGTSYIDLYYCHRVDRKTPIELTVQAMADLVNLGKVKYLGLSEVSSDTLRRAHKVHPIAAVQVEYSPFALEIESKQIDLLRKCRELGVAVVAYSPLNRGMLTGAYKSPDDFEETDFRRVAPRFSKENFPKNLKLVDRIVDIAKAKGVTPGQLTLAWLMAQGDDIFPIPGTTKAERLEENVASLKVQLTKEEEKAIRKACDEAEVVGTRYPEFFMQTCYADTPPLEHNNGTATSGSGVKPTHSADIMGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2STR4</accession>
    <name>M2STR4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_308383</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698754.1">
        <property type="nucleotide sequence ID" value="XM_007700564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STR4"/>
    <dbReference type="STRING" id="665912.M2STR4"/>
    <dbReference type="GeneID" id="19136327"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_308383"/>
    <dbReference type="eggNOG" id="KOG2895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018994_0_0_1"/>
    <dbReference type="OMA" id="WKRRVPT"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="463"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="104"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD65675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="508" mass="58685" checksum="3785A2BB6288F69A" modified="2013-05-01" version="1">MSAPDDDAGPVPPKSHSEPQLGVSALSARPLPGDSTHSGTAFLDDTAPSSVNQPTSSPGLSRSASFSNSSYHDESDPEDASFFPPVEKLTMFDFVENLALAQRIEKIQNSISSQTERIKNQAKNRGITRDRVVEEWRRRVPTEAEQLDKYKKRMRRSVDRLNQRWNESLTVTAREKTSFIAAVLNIFVSGYLVGSHPEWFPHWYTAQLLYFMPIRFFTYHKKGYHYFLADLCYFVNILLVLTMWVFPQSKRLFISTYCLCMGNNAVAIIMWRNSLVFHSMDKVVSLFIHIMPCVTLHCIVHLLSPEYQQEHYPAIYNIRHSDPTSPHHYGLFQMMLWATCPYAVWQLSYHFLITVRRRDQIAAGRPTSFTWLRKSYAKTWIGKVVLALPEFLQEPAFMFIQYSYAVLTMIPCQVWFWYRWPSGLFLSIVFVWSVYNGATYYIDVFGNRFQKELEQLKKDMAKWQSSPEGGFTPYTPAGDNAEKQLGYIPPLEGSTSVRPVDGETRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU02</accession>
    <name>M2SU02_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_203258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704436.1">
        <property type="nucleotide sequence ID" value="XM_007706246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SU02"/>
    <dbReference type="GeneID" id="19134248"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_203258"/>
    <dbReference type="eggNOG" id="ENOG502SUZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023459_0_0_1"/>
    <dbReference type="OMA" id="VDIWCGD"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="52"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="677" mass="76119" checksum="CE22ECC2E70EDC88" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU85</accession>
    <name>M2SU85_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_98799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703736.1">
        <property type="nucleotide sequence ID" value="XM_007705546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SU85"/>
    <dbReference type="STRING" id="665912.M2SU85"/>
    <dbReference type="GeneID" id="19141823"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_98799"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034009_0_0_1"/>
    <dbReference type="OMA" id="SFYTKDV"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="146"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD60362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="409" mass="46558" checksum="427F4986CE649A7F" modified="2013-05-01" version="1">MAPRPPPPAVTDPPKPGAITNPAVEQKIGQATSVIIPLLEFGAVGYETWVFVYLICIKYLINPSDQIQRDFNIQPRRSTGIALIVVYALLMLFLTITWLRLLQMIWSRPDIVPFGNTAQEKEHASTRDFAFDQYDAFVCDYQGLPLWCDKCHNWKPDRTHHCKELGRCVRKMDHYCPWAGGIIGESTHKFFMQFVAYAALYTTFTWIVVAIFLAERNSKMGSRPGTWIGALAVGVLFSLFSFTMSCMTGWNLMINYTSVEGIQRGGIHNIAFLVSQPSRRSSTTLPPGTPPLPSGKAHKKNSDRTTEGERVEEDWPILTTVTRASKRSYVVMQTKPFEHPWYTSLMQGWKDTMGNGILDWLLPFKQSPCKNRSHRGEFAWGEVVYDMARMYEEKHPEARLALLHGSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUA6</accession>
    <name>M2SUA6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_99359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703752.1">
        <property type="nucleotide sequence ID" value="XM_007705562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUA6"/>
    <dbReference type="STRING" id="665912.M2SUA6"/>
    <dbReference type="GeneID" id="19141849"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99359"/>
    <dbReference type="eggNOG" id="ENOG502S42E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067890_0_0_1"/>
    <dbReference type="OMA" id="CHLGFVR"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30565" checksum="51DC297DE61C8AB2" modified="2013-05-01" version="1">MSSPSYPKTAVNKLGRLPNRGYPRYIKKFPGTYDYQTIHTLINRTPILHVSFTDPAHPFPVVLPMLGCTGNYSSPNDSPAQDVYLHGYISGRLFKQSAGSPQQQNQQEKNEEGLPVTIAASNLDGLVLSLTPFHNSCNYRSAVVYGYASLVEDEDEAMWAMREITENMLPGRWEGSRVPPTKAEVNSTGVIRVRVVSASAKIRTGGPSEDRADLKNAELVKKTWTGVVPYWGSWGEPVPGKENGCEEVEEYIERWRVVENNRGRQEAFDATTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUV6</accession>
    <name>M2SUV6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_244497</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="DCTN4"/>
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        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
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            <end position="211"/>
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            <end position="403"/>
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            <begin position="173"/>
            <end position="194"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="14">
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            <begin position="378"/>
            <end position="396"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00093507"/>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    <sequence length="119" mass="13122" checksum="1B6C77D5EA93873A" modified="2013-05-01" version="1">MHVPMYVVCGQRPSIYTVVLYTYTLNWLCFHVVAVGNCALTWASHAWAPCPHTHTTLCLAAPRLALPCRARSLACLASCVVFRRVATRANAPGPCYPLLDPRPWRPPSRSSASSARRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60956.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="201" mass="21871" checksum="DFBAFAC5735C5F7D" modified="2013-05-01" version="1">MCVAELCVTVLPCKHRWYHLVRPCTPSSNLSTCGKKLGISGWEVKCNHCPYCHGHVSEFEYKLIGDGPAPPVGSLSGLARAHSTSLNAARRDIRLDNITRTDSATSVGSKSSLVTAASEKNRAMNSRLDAYFFPSPDSPYPAVREDDNESNPCGSPSDTSVSDYSSVRHASISMPAGAETHKANMLSRVRQRTKRISGIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SW75</accession>
    <name>M2SW75_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crh-like protein</fullName>
            <ecNumber evidence="14">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_97196</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="14"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703543.1">
        <property type="nucleotide sequence ID" value="XM_007705353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SW75"/>
    <dbReference type="STRING" id="665912.M2SW75"/>
    <dbReference type="GeneID" id="19141723"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_97196"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_3_2_1"/>
    <dbReference type="OMA" id="DDDNWEG"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 14 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026188" description="Crh-like protein" evidence="18">
        <location>
            <begin position="20"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="270"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="284"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD61256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="377" mass="39593" checksum="4FAE8D12C57B2F8C" modified="2013-05-01" version="1">MLFPTSLLVLSGLTYSVFGQTHTDCNPTKKSCPAAAALDTSYYSRDFTKEGADDDNWKMTAAGVSYSDKGAEFKISKKGDHPTIQSKWYIFFGSVSFLMRVAPGTGIVSSAILQSDDLDEIDWEWLGGQAAEVQTNYFSKGNTATYNRMAKAAIPSGNAETELHNYTISWTQNSMQWIIDGSVQREVKYADVNSAYGYPQTPMNVRIGIWAGGDPDNSDGTIEWAGGLTDFGKGPYSMVVEKVEVINHAPAKQYHYGDLSGTYDSIVVDKKGDGNGDKSKSDKSSSSASASASASASKSMTTSMSSSATASATSSATTSGASSEGASNGPSKTAAAAVADQAASTSSALPESNGAGVESVKWRYAALMGAVAIAFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWZ4</accession>
    <name>M2SWZ4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_173696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702727.1">
        <property type="nucleotide sequence ID" value="XM_007704537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWZ4"/>
    <dbReference type="STRING" id="665912.M2SWZ4"/>
    <dbReference type="GeneID" id="19132874"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_173696"/>
    <dbReference type="eggNOG" id="ENOG502R029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076082_0_0_1"/>
    <dbReference type="OMA" id="NPPFMVD"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="1">
        <location>
            <begin position="148"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="355" mass="38726" checksum="A3BB0983E8EE31F6" modified="2013-05-01" version="1">MTESTAFQALTRHLAKSNYVFVCPSPETQGRVVQKRHSNVSTKDAQTASDFFGWNLSCARETLKSMIPDAIFEQLCKSSVIVEDNNKMYRSTIRVSNFYLQDPLNRDPDTTSLYYIHSSFPASSNSVFFGPDTYLFISFLQTLPRYLPQAPSLAIDVCCGSGAGAIHIARTYPQAKVLGLDLNPQALSLGGVNAQLAGVEVTFSESNLYTSLPEEMKGRGVDLIVSNPPYIASSVDGKDLPIYADGGAGFGLDISIRIVEEGIKILSSNGVIVVYTGVAIPTADPGHDAFLEKLKQVEDGELAEYKILHPDMWPEEIGKGAYADVCRIQIVGAVLRRNVKSKEETKAAARSQWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYD6</accession>
    <name>M2SYD6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trm112p-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_173353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702311.1">
        <property type="nucleotide sequence ID" value="XM_007704121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYD6"/>
    <dbReference type="STRING" id="665912.M2SYD6"/>
    <dbReference type="GeneID" id="19132847"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_173353"/>
    <dbReference type="eggNOG" id="KOG1088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086140_0_0_1"/>
    <dbReference type="OMA" id="NMLTSKC"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16681" checksum="060A331245522CF7" modified="2013-05-01" version="1">MKLLTLNFLTCAIKACKTNPASFPLHPRDAELEIVEADVNLAFLKNILPRILWNELRVICSELGLPELPPTAPTPADLVEPSSSSASALDTAEATPAADAQEEEEEEPSQTAKDLHRILLETCIKEGKLVCGACQHEYAVKEGVANFLLPGHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2T056</accession>
    <name>M2T056_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701599.1">
        <property type="nucleotide sequence ID" value="XM_007703409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T056"/>
    <dbReference type="GeneID" id="19139233"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38354"/>
    <dbReference type="HOGENOM" id="CLU_2170633_0_0_1"/>
    <dbReference type="OMA" id="CHFTIAP"/>
    <dbReference type="OrthoDB" id="10310485at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025516" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14467" checksum="C2F182920C48BEDE" modified="2013-05-01" version="1">MVVCLDLALTFVPCTVWIGLTLTPGATMPDRATRWPFVFWASFIARLHARRLQSSRAANMTTYYVPSALNRPADPGPGSWKTPFPGKPNFCRPLVAPSVAVVHAVFCHFTIAPRTARSCRQTWCSGPDGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0V7</accession>
    <name>M2T0V7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_222761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2S1</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696295.1">
        <property type="nucleotide sequence ID" value="XM_007698105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2S1"/>
    <dbReference type="STRING" id="665912.M2T2S1"/>
    <dbReference type="GeneID" id="19135726"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_276539"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_2_1"/>
    <dbReference type="OMA" id="DMVNIEE"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001856">
        <property type="entry name" value="RAS small monomeric GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25359" checksum="218D3E3AE1E565BF" modified="2013-05-01" version="1">MDENNRITITVCGDGGCGKSSITLRLVRSEWTSEYDPTIEDSYSVTRTIDGVPYYLMLTDTAGQEEYRGLWAASNLQSDAFLLVYDITAANSLDALDYFMEMIDMETDNRLDNGKIPPIKCVVGNKCDLQGQRVIEAKKGLEWARNRKCGFMETSAREMVNIEETFALLVRRVVEARRLTANENAANRTAALPISNANLSGAHTYSEKHDSDESRQSFWSKLKCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2T3</accession>
    <name>M2T2T3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metal homeostatis protein bsd2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_81137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696302.1">
        <property type="nucleotide sequence ID" value="XM_007698112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2T3"/>
    <dbReference type="STRING" id="665912.M2T2T3"/>
    <dbReference type="GeneID" id="19140819"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_81137"/>
    <dbReference type="eggNOG" id="KOG4812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041193_0_0_1"/>
    <dbReference type="OMA" id="SFVWNGM"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37271" checksum="BA269DED2E97B568" modified="2013-05-01" version="1">MPSQRYERVAAQDEDDSHASSTSAQQWPPASPPPSFHSRASSPNGTSRRLLAQDPAPTDEDRTLADTFDSDSDDDDDDNGDDRQRLMRGNPRSEDEPPAPGIQRRVTELPVFNTQAPSSGRVYGGGNGGVWANLSAKPTRGEDAEEKPPTYEQAAADATPPYWETTILAPGTFGDEVFVEGLPVGSLFSFLWNAMISMSFQLVGFLLTYLLHTTHAAKNGSRAGLGITLVQFGFGFRSAVLNPSNGSNDNPGQGFNGGVPSDPNSHDFDPDKVSTGGSAGTGGDSTPASSAITGSDWVAYGLMIVGWFILIKSVSDFIRARRHEQLVLQSPDRGLGVAVVAEGESPERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2T8</accession>
    <name>M2T2T8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_276687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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            <end position="66"/>
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            <begin position="191"/>
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            <begin position="274"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD68995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34014" checksum="45574E835E586EDB" modified="2013-05-01" version="1">MTYTKKQIVTCLSVVYLVIAAALAGANTLSYAASRANARSVPIAETLTGFTTALPIVSGLLLELGYDLTRRRERRQRLGRGDIQRPPLVIIANTLIFIYSTVIITLSGTHVAPASSLNCGLRERWQTLFKHKDATAIRQIQDAFSCCGLVNSRDMAWPFPDRTHDSRACEATYHGRASGCLVAWKAEEQKIAGLLMTVVGMVFLWQFAIIAIPTQKDSWLHKIVPDRLSRVLAGDEGGDADSRRAIDYVPGYNRYSDRIEEEAEEDDEQTPGRAIEDGIRHTDHVFPAQIGRDRQPSVENEWSRGA</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69150.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="256" mass="28394" checksum="D085CBC3485C1A88" modified="2013-05-01" version="1">MDQIPSILYADENFKTWLILGASRGIGLEFVKQLLAKNERIIATVREPWAGHASGLWGQAGGDHGRCQMYTCDILSELSIEKFVAQLAAQPNLKIDYVVLNAGVLRYPNRATELSFDEFAFHLHTNTIGPIIAAQKLLQTKIPIGTIVFMSSDSGSHGNFREMEDGFAAYAASKAALNMAARHMAAELKRKDDDTIILCMHPGEVATDMANIQLPWTVEGIISPEESVVKMIEVITSKGIQHSGTFWTWENKPYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4A0</accession>
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            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700463.1">
        <property type="nucleotide sequence ID" value="XM_007702273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4A0"/>
    <dbReference type="STRING" id="665912.M2T4A0"/>
    <dbReference type="GeneID" id="19139023"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37601"/>
    <dbReference type="eggNOG" id="ENOG502QUK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_3_0_1"/>
    <dbReference type="OMA" id="LEHSHVW"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF129">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="473" mass="51390" checksum="5108E864BB62AD40" modified="2013-05-01" version="1">MRQERATLPTPTSSNSFWHSEPNEYLIGHRTTENLPAEADIVIVGSGITGASAARYLAEDERANGKSIVMLEAREACWGATGRNGGHCQPLLFDRSSDVARFELKNVATVRSYVQDNSVPCEWRDVAGCRTFWNQAALKEVENELRHLRNVAPEIAAKVTVIKDKEELKKHRVAPDCLAATLSEGAASLWPYKLVTFILQKLVQDGRVNLQTKTPVAKITTSEGKHTLHTPRGTISSKTVILATNGYTSALLPHFADLIVPCRGEMSALFPPEGSTLLPNSYGMVAALGQPAHNDDYLIQRPFEGVPNPAGHLMFGGGRGAGNYPSLGISDDSIIDEGSAAYLRGALLKVLELDGKTEGLKELKAAAQWTGIMGYSRDNHPWVGKVPDRDGLWLCGGYTGHGMPNGTLCGKAIVDMVLAEIGGQDVSAVQAQMVQQGDIPKSYILTKERIDKARRMLTVHQQEEHGVYMNGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4A9</accession>
    <name>M2T4A9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_32012</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694170.1">
        <property type="nucleotide sequence ID" value="XM_007695980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4A9"/>
    <dbReference type="STRING" id="665912.M2T4A9"/>
    <dbReference type="GeneID" id="19136601"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32012"/>
    <dbReference type="eggNOG" id="KOG2240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098726_2_0_1"/>
    <dbReference type="OMA" id="RMQQSVR"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD69265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="160" mass="17609" checksum="D1C1883CE669AC54" modified="2013-05-01" version="1">MDHAKLARMQASVRIGGKGTPRRKVKKVHRGAGTDDKKLQTALKKLNVQPIQAIEEVNMFKSDGNVIHFSAPKVHASVPANTFAIYGHGEDKELTELVPGILNQLGPDSLASLRKLAESYQSMQKEKGEDSEKKDEDDEDDDDIPDLVAGENFESKAEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4W1</accession>
    <name>M2T4W1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_186361</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694782.1">
        <property type="nucleotide sequence ID" value="XM_007696592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4W1"/>
    <dbReference type="STRING" id="665912.M2T4W1"/>
    <dbReference type="GeneID" id="19133558"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_186361"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_5_2_1"/>
    <dbReference type="OMA" id="QIVNHMV"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000055">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="14">
        <location>
            <begin position="94"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="13">
        <location>
            <begin position="285"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD69465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="605" mass="66979" checksum="5429A3E6184C0825" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M2T685</accession>
    <name>M2T685_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_325807</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700256.1">
        <property type="nucleotide sequence ID" value="XM_007702066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T685"/>
    <dbReference type="STRING" id="665912.M2T685"/>
    <dbReference type="GeneID" id="19136831"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_325807"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_1_1"/>
    <dbReference type="OMA" id="MVDIMKF"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        </source>
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        <source>
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        <source>
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        </source>
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    <sequence length="853" mass="92829" checksum="866CBF3ED15195AE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6L8</accession>
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        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="12" type="ORF">COCSADRAFT_216437</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="313"/>
            <end position="484"/>
        </location>
    </feature>
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        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD70050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="507" mass="54339" checksum="5CAFE9E871D5A6BD" modified="2013-05-01" version="1">MAHPSGSGGTSFAPTPTHPHQLSRETSRDELDMAESLRLLNQTHEHQKPRVEATSQEQQQQQQQQHTHAQEDQRSEIYHSLEDAVPIADAPPTPSTAASLQIPNMNYETPNASITGQICSNCKTTQTPLWRRSPAGETVCNACGLYMKARNQSRPVNLKRNTQTQPSMSVQQSPTPGSTDGGRTCAGNVAGSPRVATYVAADQMAAGTCPGGGRCNGTGGQQGCSGCPAFNNRVSKTAKFALAQANAAPGENRGGSDAASSTSASASTSAIPACQNCGTTITPLWRRDDAGHIICNACGLYYKLHGTHRPVAMKKQEIKRRKRIVPAAETGSQAASSVANYSPPQRPSQTPAFEHSVSPDPSTALESREDYTPEPPRGPIAVDFTHYYSNSSVTSNPVALTPSMQPSAPSPRKRSRSATLDPEEPVNPLPHRPNAISSILNPSQTDADANIDPSLSVPLRTSGGTSPNSTLSQEEKAAKRERLKREAEAMRLELERRQKELEELEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7J2</accession>
    <name>M2T7J2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaminase GtaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_171000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699658.1">
        <property type="nucleotide sequence ID" value="XM_007701468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7J2"/>
    <dbReference type="STRING" id="665912.M2T7J2"/>
    <dbReference type="GeneID" id="19132721"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_171000"/>
    <dbReference type="eggNOG" id="ENOG502QPQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008020_1_1_1"/>
    <dbReference type="OMA" id="WAGMIRV"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
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        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026169" description="Glutaminase GtaA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="106"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="344"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="78873" checksum="C2C38EB7090C4C25" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7T0</accession>
    <name>M2T7T0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_303886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698485.1">
        <property type="nucleotide sequence ID" value="XM_007700295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7T0"/>
    <dbReference type="GeneID" id="19136236"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_303886"/>
    <dbReference type="HOGENOM" id="CLU_1234910_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="224" mass="25484" checksum="730D815C365DC0C3" modified="2013-05-01" version="1">MHAPLDIIVPPSQARLVHPRHCHYHCHYHCHASSTAMVHPVRKQIRRTSLSVFVCRPLSVSLSNKNKNITNPNPGENQSQTSHPLLIGRILSWFPHLFIFFLSSPCSRLFSVSPLSVFPLRTERRRPPLVRTCLVHILLKYLSHFTSWPLHLHSQTTLAKGIRILHFETTSLHPHPQKVAGSTRQTKKKRTRKEKMTDIIPSKKASDLPKGQSSPHESTNASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8K6</accession>
    <name>M2T8K6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_35366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698288.1">
        <property type="nucleotide sequence ID" value="XM_007700098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8K6"/>
    <dbReference type="STRING" id="665912.M2T8K6"/>
    <dbReference type="GeneID" id="19138248"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35366"/>
    <dbReference type="eggNOG" id="KOG3170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072604_1_0_1"/>
    <dbReference type="OMA" id="FCEIRAN"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="46"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="250" mass="28513" checksum="E35FA0B485273EA8" modified="2013-05-01" version="1">MQMPDMPVNVAVDDPNADTEWNDILRKHGVIPEKPPSPTPMIQEALEQARQLAHENRLEGKDLDELDELEDLEDDDFLDSYRQKRMAELSSINTASVYNQVYHLQKPDYSRDVTEASKDAYVLVLLTSSTGTNTESRIMIEHWRELAKRFGDVKFCQMRADLCIEGYPDKNTPTVLIYKDGDIKRQIVTLMQLAGPRTSVQDLEKVLVDVGAVKLGDSRLQRKKEEDGEESSNKIRQGKTVAEDDDSDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9E1</accession>
    <name>M2T9E1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_35841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698412.1">
        <property type="nucleotide sequence ID" value="XM_007700222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9E1"/>
    <dbReference type="STRING" id="665912.M2T9E1"/>
    <dbReference type="GeneID" id="19138559"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35841"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_1_1"/>
    <dbReference type="OMA" id="ESSALWW"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="210" mass="23067" checksum="04AE9892825DEFD1" modified="2013-05-01" version="1">MPLLHLANELLCSISENLQLERDINAFAQTNRRLYHLLNSYLYRYNIRHSESSALWWAARHGQEATAQKLLEERADDQGASDWYWLLCVAAEQGHKGMVKLLLDKDAAGDGQGGGYGDALQAASYKGHEQIVTLLIDRGANVNAQCGQYGNALQAASYKGNLQIVKLLLDKDADVNAQGGQFGNALQVASYGGHESIVKLLLERGAQQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9I8</accession>
    <name>M2T9I8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_310987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698935.1">
        <property type="nucleotide sequence ID" value="XM_007700745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9I8"/>
    <dbReference type="STRING" id="665912.M2T9I8"/>
    <dbReference type="GeneID" id="19136380"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_310987"/>
    <dbReference type="eggNOG" id="KOG4499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_3_0_1"/>
    <dbReference type="OMA" id="WAGTMRY"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="329" mass="36683" checksum="5A67D10D96083F09" modified="2013-05-01" version="1">MSEVKKYEITEPWLKTHCALGEGPFWEEDRNSIRFLDVEKQAVMRVDLAKGPSSFKTIKNYDISIGCTADIEGNDREFIFAGKYGFGIANKETGEYRWLKKVWSSSEISANKHEIFRGNDGAVDSQGRFWAGFMFDPLVSDMRSDGAVFRLNPDLSLDRPMDDICIPNGTTWNKQDDILYFADSPSKTIYQFDYDAKTGEIKNRRPYFVMPEDNRYGEDAVPDGHCLDEEGYMWTALHGGSCVLRISPQGEIVAEIKVPTSQPTCPCFVGEELFITSAGGTSGENGGPVDEFAGCCFKINVGLRGLKKFKFKGGDKIEGGKLNGQVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAT2</accession>
    <name>M2TAT2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_87271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699000.1">
        <property type="nucleotide sequence ID" value="XM_007700810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAT2"/>
    <dbReference type="STRING" id="665912.M2TAT2"/>
    <dbReference type="GeneID" id="19141177"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_87271"/>
    <dbReference type="HOGENOM" id="CLU_1085818_0_0_1"/>
    <dbReference type="OMA" id="MTIEIGR"/>
    <dbReference type="OrthoDB" id="3800599at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="229" mass="26096" checksum="4D201658A2D24228" modified="2013-05-01" version="1">MALDQDGQLRCPTDSTSGISGSFQHFEEPSQTLRCVFQSNLTLAERIGQDIRAIFGTQCTPLKEETVIEFPHRSDTFKCLSEEELAVTQLALIKDHVGINAEEVFSRWNTDVAAPNWNANVIQPAVKLFMGWNRSFRTLFSMSQEAFLRVVAWGELVRLMNQSWTVMQCQPGEKVMFAQLGQVHRQFFKAKVNYDKEKKDRKISRFEALGCDMIAAYLVTMTIEIGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAW3</accession>
    <name>M2TAW3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_137921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697872.1">
        <property type="nucleotide sequence ID" value="XM_007699682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAW3"/>
    <dbReference type="GeneID" id="19131070"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137921"/>
    <dbReference type="eggNOG" id="ENOG502RXC5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046558_0_0_1"/>
    <dbReference type="OMA" id="QTRCVQI"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.160.10:FF:000001">
        <property type="entry name" value="Altered inheritance of mitochondria protein 24, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD66361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="381" mass="41353" checksum="CDC3996C32D9A677" modified="2013-05-01" version="1">MLRTAASPWANLARTCAPAGRPSIAARCINISATSPSPEPSLQQAVSVEGTATPMHTPDARFDVIGTPFSLLSVSLSASQTLYTRRGTLVGLSGKSENTLSTLSVLEPFQRAPVGIPFLYQKVSSTSPVTALISTKTPISSIVSVNLDGRDDWIISQRQALLAWTGLTLKLKPQYNVKLGLAHWGNTYITGRGLLALTGNGQIYQVHVKAGESYVAHPSNVVAYTASNTPPVPFRFKSSNLRFQVPDLGFGSLVQNTQFFRTMSKTATWRALATTYHTLKTWMRRTVWGDRLFLRFEGPTTMLVQSRASRISDVLTLRDVDEIADSPPGAVEDAVTRKIKEEIKSIGEQGTKAPVPNTDASGTVRYATIKDGKAEFEKPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBN4</accession>
    <name>M2TBN4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CinA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_34838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <end position="167"/>
        </location>
    </feature>
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            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="121"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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    <sequence length="175" mass="18136" checksum="D312B530352C2B5D" modified="2013-05-01" version="1">MPPPSFPPEELRLIVQEVATLLKERKETISVAETAAGGLISAALLSFPGASSYYRGGLTLYTLESRIAFAGWTQESVSGYSGPTPAVVSGLAEHTRSKLGSTYAVSESGTAGPTGGSTRNRTPGYVALAVAREGGDTATREAETKSSGREGNMVAFAVEALKLVRDVIKADGGKL</sequence>
</entry>
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    </protein>
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        <lineage>
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            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="460"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="544"/>
            <end position="608"/>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
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            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="63542" checksum="B1B55C2C4B9453DA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TD51</accession>
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            <fullName evidence="11">Amine oxidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_35183</name>
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    <organism evidence="15 16">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
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        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
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        <property type="nucleotide sequence ID" value="XM_007699411.1"/>
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    <dbReference type="STRING" id="665912.M2TD51"/>
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    <dbReference type="eggNOG" id="KOG1186">
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    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="OMA" id="LYAGGWY"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="13">
        <location>
            <begin position="244"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD66677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="688" mass="76664" checksum="5291EE7511A40DFF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEM1</accession>
    <name>M2TEM1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_34049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696524.1">
        <property type="nucleotide sequence ID" value="XM_007698334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEM1"/>
    <dbReference type="GeneID" id="19137418"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34049"/>
    <dbReference type="eggNOG" id="ENOG502SQU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133933_0_0_1"/>
    <dbReference type="OMA" id="CRANAPG"/>
    <dbReference type="OrthoDB" id="4153862at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025873" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="9876" checksum="32316996F574C18A" modified="2013-05-01" version="1">MQFTTSAIILALSALAAAMPQGANANRPVPNGACCVANTSLKQDVCNVNGQTGRCVPDSVNNCGAQLTCIEDSRLTCDPNTLERGRPLCRRTPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF23</accession>
    <name>M2TF23_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_111021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697027.1">
        <property type="nucleotide sequence ID" value="XM_007698837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TF23"/>
    <dbReference type="STRING" id="665912.M2TF23"/>
    <dbReference type="GeneID" id="19130142"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_111021"/>
    <dbReference type="eggNOG" id="KOG3742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015910_1_0_1"/>
    <dbReference type="OMA" id="RDVRNHI"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="704" mass="79705" checksum="F069B1E14691F923" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF96</accession>
    <name>M2TF96_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_32885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695395.1">
        <property type="nucleotide sequence ID" value="XM_007697205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TF96"/>
    <dbReference type="GeneID" id="19136942"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32885"/>
    <dbReference type="eggNOG" id="ENOG502S2KS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086074_0_0_1"/>
    <dbReference type="OMA" id="CNMWRTV"/>
    <dbReference type="OrthoDB" id="61370at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="249" mass="27341" checksum="41F03671A15E0D02" modified="2013-05-01" version="1">MTRRTVYAAGLVLTLACTIMTIASISMPRWVSYSPNGEREYSYGLHTRCSAITGTCVSFPKSSDCTKDPSFCNMWRTVGFLTSFGVVVELCAIVAFVVIISGGVQRRAAGWQVAVGVLSFSAIVQCAGMAIVAFLFDHDDRFWNGWHLDLSWSLCTASWTILILTSIGIAASAFYLPAEGDYELIPEDYYGPPDDRLLSRISAWDNGFKGPDSGMQYSYQRDQDSMSDVVSIAASSIAASHRRESDVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFZ0</accession>
    <name>M2TFZ0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein alpha-3 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_133578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFZ0"/>
    <dbReference type="STRING" id="665912.M2TFZ0"/>
    <dbReference type="GeneID" id="19130893"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_133578"/>
    <dbReference type="eggNOG" id="KOG0085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444929_0_0_1"/>
    <dbReference type="OMA" id="RFNWDEL"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:heterotrimeric G-protein complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="69113" checksum="66FEF568198E0FB1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2TH70</accession>
    <name>M2TH70_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_22544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695359.1">
        <property type="nucleotide sequence ID" value="XM_007697169.1"/>
    </dbReference>
    <dbReference type="GeneID" id="19134666"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_22544"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002763_0_0_1"/>
    <dbReference type="OMA" id="FDRHTQY"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="613"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1111"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD68062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1303" mass="144429" checksum="A5109DD1A4991CAE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2THC1</accession>
    <name>M2THC1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_33060</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695442.1">
        <property type="nucleotide sequence ID" value="XM_007697252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THC1"/>
    <dbReference type="STRING" id="665912.M2THC1"/>
    <dbReference type="GeneID" id="19137020"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33060"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_12_0_1"/>
    <dbReference type="OMA" id="ADIHYEV"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
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        <property type="entry name" value="Globin"/>
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    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
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    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
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        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="150"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMD68097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="432" mass="47832" checksum="A24BFB47EAE85D8E" modified="2013-05-01" version="1">MATLTPTQVQIIKSTVPVLAEHGTAITSRFYHDMLQAHPELKNIFNNTHQATGHQAQALAGSLYAYAANIDNLGKLSPAVELICHKHASLFIRADQYDIVGKHLLSTMSSVLGAAATPEILDAWGAAYWQLANIMINKESQLYRSTSYWPSWQDFRIAKKVQESEEITSFYLEPVDAAKLKLPRFKPGQYISVRVFVEELDGGVWQARQYSLSDAPGKSYLRISVKKEAGVVLGENKDMTHVGYISNLLHDAKHEGDVVQVSHPFGDFHLVDSEEAGHHDDNTAATAGGPVVLISAGVGVTALMSMLNFLIDEADSPRPITWIQGARNSQTRAFKKHMDQCVVANHGNVHAVYYLSRPSQEDMQGHDYDIKGRVDLDRVDRTILHTDNSSTMYYCCGPTSFMLDVEAQLKSYGVPSERVKMELFGTGGVPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2THF5</accession>
    <name>M2THF5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_80073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695824.1">
        <property type="nucleotide sequence ID" value="XM_007697634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THF5"/>
    <dbReference type="STRING" id="665912.M2THF5"/>
    <dbReference type="GeneID" id="19140764"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80073"/>
    <dbReference type="eggNOG" id="ENOG502RPQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024519_1_0_1"/>
    <dbReference type="OMA" id="WRYELDP"/>
    <dbReference type="OrthoDB" id="5280838at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55968" checksum="B5F5F6FC57FEFADC" modified="2013-05-01" version="1">MVSYPDSASAERSLPIRRPSSVASHSSRASTVRRHRQTRSNFGGSSLVSQNEFPIFTHTGDVEIIISNGRKEQRYLLHKLILTQCSGFFEAGTSDEWATAGDVTNAGPTNGTTLARIPSGSRPEQKRKWRYELDWGNGDDDVPMLVQKKNQPSTMFGGDPSTSTQPPPARNNKPAPPQSGFFRSVANFSTVNVPSAPPELDPDDDTFRDYDNLFRIFYNYPPSLDTINIATAYVECKSLLQLADMYDALGVIGPRVDHHLLRFQGRLWKQIAKYPPSYLKLGYMARSKAIFAEAMVHVVGQWPQGINQLRGQIAEPVIELIEDKVDEMDELKAKIEVKLFRLSLTTSRGERVSPSSNWLDWIAVSLFRQWLAENTTPPPAPILKSPRPQGPRGESAPLPPPPIFNTGRIFRLLGQAGSSYLNHDECKRFLRLNPEHYNRDNLKRLERRIDEIKNKAKDIVKPLMRNFLELDLREGGLPYLTCTRIDPQDFPWDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2THF9</accession>
    <name>M2THF9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_178032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695829.1">
        <property type="nucleotide sequence ID" value="XM_007697639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THF9"/>
    <dbReference type="STRING" id="665912.M2THF9"/>
    <dbReference type="GeneID" id="19133119"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_178032"/>
    <dbReference type="eggNOG" id="KOG4453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031477_2_0_1"/>
    <dbReference type="OMA" id="NYWREMS"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52215" checksum="B34F7074FFD44B5A" modified="2013-05-01" version="1">MPQDYCFAAAVAVGPSHPLLTRPKHTGVLKATLPRDSCDTPTQPRPLCPESSGPRSLLVHLALLCSTARSTLSGVIRTPTFPYFPVCWRVAMESSRQYQVPHTPRVISPSPTPSEAGSTRDGYFGPVTRSATRKQRVTSPPPIDEDLSGSDPDQRARTRSRSPAVAKMAGKRRMSALASRRQMNGVSKKELSLPGDTANGHLSPAAANKNYWREMSRSPSPLGLIPIHQKWRSFIHRHEIPRKILHVSIGFLTIFLYCTGTQTSQIHNVLLTLLVPIALTDVIRHRYWQVNRLYIRFLGALMRESEVDGYNGVISYLLGAWIVMRFCPKDIAVMSILLLSWCDTAASTFGRLWGHLTPRVRKGKSLAGSIAACVTGVITAAVWWGWLGPTFSEYNHGEHTFAFQGALMLPLQARERLNLSVSQASITGHVALGVMSLAAGIIASASEAIDVFGWDDNLTIPVLCGAGLWGFVKMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2THY1</accession>
    <name>M2THY1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_79109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696334.1">
        <property type="nucleotide sequence ID" value="XM_007698144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THY1"/>
    <dbReference type="GeneID" id="19140711"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_79109"/>
    <dbReference type="eggNOG" id="ENOG502T2RR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119650_0_0_1"/>
    <dbReference type="OMA" id="NERDDNM"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="143" mass="16092" checksum="E4BEBC923451D667" modified="2013-05-01" version="1" fragment="single">RDLINSLVKSMKRPADEKCFTCLCKDGVLRILYFLPASLDEPTPIVVYDAKPLSLGLLKAYLDYRMEWSQEVEDRFRGVDGTSVPQGHWLHTPPGVIESRGSKNERTEEIHRYNDKVRQGEGSSNAARPACGGMPNNFDIGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKK0</accession>
    <name>M2TKK0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_32363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694271.1">
        <property type="nucleotide sequence ID" value="XM_007696081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKK0"/>
    <dbReference type="STRING" id="665912.M2TKK0"/>
    <dbReference type="GeneID" id="19136742"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32363"/>
    <dbReference type="eggNOG" id="ENOG502QPI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000998_3_0_1"/>
    <dbReference type="OMA" id="GPNLWND"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="164"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="392"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="473"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="763" mass="85046" checksum="44E7465A0B686245" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2TL45</accession>
    <name>M2TL45_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_166820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695071.1">
        <property type="nucleotide sequence ID" value="XM_007696881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TL45"/>
    <dbReference type="GeneID" id="19132476"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_166820"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045863_0_0_1"/>
    <dbReference type="OMA" id="GIHYGTH"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="183"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="368" mass="41136" checksum="296A95A0473FFEC9" modified="2013-05-01" version="1">MVDNRGSTMPPGHRATIGHLQTFELPESLSGNAADKALGKSMIDAWRKDGILQISMDPINRKLADAAFLCSKKFFSLDYNKKASCLDDQSFAGYIASGEEITDNIADYSEIFTVTKDLALSDFRVQQKWPCHGPCPWPFGQMKTVMQAYMDYLGESGEKMLQLIAWGLGMEDGNALTRYTQDGWHHMRILRFPEANNVNGKGKAGRGIGSHTDYGLLVIAAQDDVGGLFIRPPIQGETFANWKESAAGKHEDADGWVYVPPVPDVFTVFPGDMMQYITNSFLPSTPHKVGLNTRERFAFAYFHEPNFSAVMKPLPGFEARDPISGIHYGTHFTNMFMRNYPTRVTADRIRAEDRMALLESPSLRELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSF9</accession>
    <name>M2QSF9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_42098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445708">
        <property type="protein sequence ID" value="EMD58124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706174.1">
        <property type="nucleotide sequence ID" value="XM_007707984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSF9"/>
    <dbReference type="STRING" id="665912.M2QSF9"/>
    <dbReference type="GeneID" id="19140163"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_42098"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_3_1"/>
    <dbReference type="OMA" id="AVHTQHI"/>
    <dbReference type="OrthoDB" id="3791627at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD58124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="523" mass="57782" checksum="C10546855A6BD1E8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2QVV8</accession>
    <name>M2QVV8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_41102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ND90Pr</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704850.1">
        <property type="nucleotide sequence ID" value="XM_007706660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QVV8"/>
    <dbReference type="GeneID" id="19139908"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41102"/>
    <dbReference type="eggNOG" id="ENOG502QPR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024588_2_0_1"/>
    <dbReference type="OMA" id="GLYDGNY"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF20">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="220"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="428" mass="46045" checksum="704B602F2C213F1D" modified="2013-05-01" version="1">MTSSSLKINGDRLNSTLQDTCTQYGALAAPSTGMCRLTLTPEDQAARDWLVAECKSLGCEIKVDQMGNIFAIRGGTAKDKKPIGMGSHMDTQPAGGRYDGILGVQAALEVLRTLHENNISTHCPLALINWTNEEGARFPGAMMSSGVWSQHSSTPLSTCWSILDTDGITMKDALQSINYLGETPCSHLDNSLHCHFELHIEQGPLLERAQKTVGVVETVQGMQWYAVRVLGKEGHSGTTPMPDRSDALVTASRLITAVRDTALHTELGVATVGVIKSDTASQATIPAGVAFIIDIRCSTDALVAQLSNAIFAAFDKIMTEETNGTSYKVQRTWGLPESKFHPHCIEAVRGAAVKLVGEDQVMSMMSRAGHDSAWTSRVVPTSMIFVPSRDGISHNPEEYTSPEHCALGAQVLLDAVLAYDEMVAKGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2QVZ6</accession>
    <name>M2QVZ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_127796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705031.1">
        <property type="nucleotide sequence ID" value="XM_007706841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QVZ6"/>
    <dbReference type="STRING" id="665912.M2QVZ6"/>
    <dbReference type="GeneID" id="19130697"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_127796"/>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004457_0_0_1"/>
    <dbReference type="OMA" id="WWREQRG"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="431"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="727"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD59269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="808" mass="91715" checksum="1E73CB461099A2C0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2QXW4</accession>
    <name>M2QXW4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_29971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704023.1">
        <property type="nucleotide sequence ID" value="XM_007705833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QXW4"/>
    <dbReference type="STRING" id="665912.M2QXW4"/>
    <dbReference type="GeneID" id="19136149"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_29971"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OMA" id="QFMMYEL"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000119">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD59909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="330" mass="35967" checksum="F30BF9435B7D53BE" modified="2013-05-01" version="1">MSQAQEKAQEKLAESTTAVPQSTAAQQSDNVAHALAGAGGGLLSMALTYPLITLSTRAQVESKRAQSSTLNAARRIIKREGVAGLYAGMDSALFGITVTNFVYYYWYEWTRSFFEKAALKAGRASSKLTTIESMIAGAIAGSATVLMTNPIWVINTRMTTRKSEAQEGSLPGAPVEKAPSTLATLFALIRDEGPARLFAGVMPALVLVINPILQYTVFEQLKQLLEKKRRVTPKDAFYLGALGKLLATSITYPYITVKSRMHVAGRDGPRENMMTTFRRIIREEGYTGLYGGIGPKVTQSVITAAFLFAFKDALYAYTIQARKKLALRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2R1G8</accession>
    <name>M2R1G8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_39798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703110.1">
        <property type="nucleotide sequence ID" value="XM_007704920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R1G8"/>
    <dbReference type="STRING" id="665912.M2R1G8"/>
    <dbReference type="GeneID" id="19139570"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39798"/>
    <dbReference type="eggNOG" id="ENOG502QV77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024994_1_1_1"/>
    <dbReference type="OMA" id="KECRSSM"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="192"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD61089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="486" mass="52344" checksum="89EAB63BD143B838" modified="2013-05-01" version="1">MASKLPLPAPPRTPTPPPDEDAPQPVGLGFEGDLSSRTLASSANGLLSPMSATFPSKQYATLAPGDSISQRASPAVLYTPASATFPYTPASAASGAMDTDGPSLSGSENPNPFNFQSVTYQPGQPQAKSNDVGRRRGHKYKHSSVSHQIFLEPAPRAPLQLPASLPIPTFKEYRSSMSKDQKLRLAWCFCHLVVAGLVQWGAHESLALTVLSRLIFYDALGAFLCVAVDVGANFEVWKRSSIRHPFGFERLEVIAGLGMSVGLLFMGLDLISHGLTHALEDAGGHHAHHADGHERVSPGSIDLAALSGIVSTLVSAIVLKNHARIGKVMRLGAIANLPSVLSNPSHFLTLSCSSLLLILPLLSIQMYVWLDRTLSFSVAFSMVALGWIQGWTLGKMLLMSYSGPGVSEVVHELEADPAIRTVEEAKFWQVHYGLCQANLKVRVRNMDEIGRLRDRVGSLVRNRLGGGYGSGGQKWEVSTQITLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2R2R9</accession>
    <name>M2R2R9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS19m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_96097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702847.1">
        <property type="nucleotide sequence ID" value="XM_007704657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R2R9"/>
    <dbReference type="STRING" id="665912.M2R2R9"/>
    <dbReference type="GeneID" id="19141659"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_96097"/>
    <dbReference type="eggNOG" id="KOG0899">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_1_2_1"/>
    <dbReference type="OMA" id="YVAFEIT"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="93" mass="10523" checksum="80325AFA9231B713" modified="2013-05-01" version="1">MFPTRALCARSVWKGPNIVPLPIVQKKAGERVPPIKTQARSATILPNFVGLKFQIHNGKSYLDITITEDMVGHKLGEFAPTRKQFMYKQTKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2R363</accession>
    <name>M2R363_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_39343</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702629.1">
        <property type="nucleotide sequence ID" value="XM_007704439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R363"/>
    <dbReference type="STRING" id="665912.M2R363"/>
    <dbReference type="GeneID" id="19139477"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39343"/>
    <dbReference type="eggNOG" id="KOG0766">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_0_3_1"/>
    <dbReference type="OMA" id="WGIYEEL"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000103">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="116"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="222"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD61644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="318" mass="34222" checksum="F0E57C5EA4E5C774" modified="2013-05-01" version="1">MSDGGKRPSSYFHFFAGLNSGILSAVLLQPADLLKTRVQQSRSSTLLGTIQSIASGPNPIRQFWRGTLPSTLRTGFGSAIYFSSLNALRHRASLVAAARADVSLRGGEHSSSLPKLSNTANLATGAFARTWAGFVMMPITVLKVRYESNLYAYNSMLSASRDIFRTEGLKGFFAGFGATAVRDAPYAGLYVLFYEQSKRRLSSLASKIEETSGVATKLSSSTSAGINFVSGVAAAGLGTTVTNPFDAIKTRIQLMPDQYGNTIQAGKKMLAEEGVRSLFDGLGIRIARKAMSSALAWTVYEELIRRAASLKEVVEDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3U8</accession>
    <name>M2R3U8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="5">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HCR1</name>
        <name evidence="7" type="ORF">COCSADRAFT_95821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702260.1">
        <property type="nucleotide sequence ID" value="XM_007704070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3U8"/>
    <dbReference type="STRING" id="665912.M2R3U8"/>
    <dbReference type="GeneID" id="19141641"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95821"/>
    <dbReference type="eggNOG" id="KOG4813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087988_0_0_1"/>
    <dbReference type="OMA" id="KPHYALW"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD61884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="268" mass="29849" checksum="24DCFC86EAA25D49" modified="2013-05-01" version="1">MAPGKWDDEEESSGPPSPTVAPIARRSKFEDEEDEDVLESWDAAEDSEVEREKAKKAAEAKAKADAEAKANHKSKAQRIEEHRQAALRRRQMDDDGESEEEETEAERRARLRQQEIDGSRAQAEELFGDLTVSNKRSGKAVTIADESDPNNTINLSSLSIFNPNTKDQFTKLRETLTPLIAANSKKGQYTLFLQEFTKQIAKDLPSEQIKKIASGLTTLSNEKMKEEKAAEKGGKKTKAAKTKTTLNASRDVSLKADTRAYDDDDFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3Y0</accession>
    <name>M2R3Y0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_147093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702282.1">
        <property type="nucleotide sequence ID" value="XM_007704092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3Y0"/>
    <dbReference type="GeneID" id="19131401"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_147093"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="FMTGGHL"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32130" checksum="834F48619E18D9B7" modified="2013-05-01" version="1">MQRTHTTESMRVPYSNISTLNMNKAPRPGIERAPTSTNLTRPMPIQRLEGKVVMITGGGGKVGVESAGRLLIEGCNVALIDIEQTALEAAVPVLKAAIPTGAPIESRLLTIVADATKEADVEACAKKVVQRFSKLDAALLNCCQRGASKSIFDVTEDDFERIMTINAKSAFLGVKYAATAMQTTSGSGSIIIRSSIAGLRGFPNLISYSASKFALRGIALTAAEELGPLGIRVNTIHTSIIETPGYKDGWSKEKLKELKEETALDRFSSPDDVASVVAFLVSEDSKFMTGGHLKIDGGCVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2R7N6</accession>
    <name>M2R7N6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_191252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RD18"/>
    <dbReference type="GeneID" id="19136423"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_313577"/>
    <dbReference type="HOGENOM" id="CLU_1959385_0_0_1"/>
    <dbReference type="OMA" id="FPCASLL"/>
    <dbReference type="OrthoDB" id="10264490at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="128" mass="13739" checksum="B9207D8AF561DC4C" modified="2013-05-01" version="1">MLSRGRRVLLACLLDVGGGRRTSGGSGGRKRVSAVASTAHHSFLVLDSQCSSFPILSSTSFAPLSFAFLHRFPCASLLQPKTTYRSIVYLQSRHYGTVASSSLTSHVSILHKTTRVAPTLAGSFHAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M2RGF1</accession>
    <name>M2RGF1_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_189538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007700689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RGF1"/>
    <dbReference type="GeneID" id="19133676"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_189538"/>
    <dbReference type="eggNOG" id="ENOG502RZ6G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="WSIVHII"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="Trans_reg_galc"/>
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    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="782" mass="88994" checksum="FC0DE7CEF0EE6783" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2RM30</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67674.1"/>
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        <property type="nucleotide sequence ID" value="XM_007699083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RM30"/>
    <dbReference type="GeneID" id="19131869"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_158040"/>
    <dbReference type="HOGENOM" id="CLU_1906535_0_0_1"/>
    <dbReference type="OMA" id="LAMQPHM"/>
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    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="164" mass="17835" checksum="F08C5FEE3A765E42" modified="2013-05-01" version="1">MLSSVGVHTSRASLTPAVLTLQHPAIFSTTGNDIATAEITSDVAVPASRDAFDETLSSSARLFLINTNCKLLRPYRCTSMNNQAALWLARTRQVQCSVISNKKQTTDRLAMQPHMNRRKNIPRAATAGSAGIPWLKTLLTEIRERASTSTGAPTKLKVVGDTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M2RNG9</accession>
    <name>M2RNG9_COCSN</name>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_33134</name>
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    <organism evidence="10 11">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ND90Pr / ATCC 201652</strain>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
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        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
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        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="698"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="978" mass="107577" checksum="CD86F5758FF139B7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2RPJ4</accession>
    <name>M2RPJ4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_134347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696097.1">
        <property type="nucleotide sequence ID" value="XM_007697907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RPJ4"/>
    <dbReference type="STRING" id="665912.M2RPJ4"/>
    <dbReference type="GeneID" id="19130923"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134347"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308819_0_0_1"/>
    <dbReference type="OMA" id="HSIEAPQ"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="337"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="953"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="844"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="899"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD68519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="107584" checksum="386C7D420916D308" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQL9</accession>
    <name>M2RQL9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_33724</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695611.1">
        <property type="nucleotide sequence ID" value="XM_007697421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQL9"/>
    <dbReference type="STRING" id="665912.M2RQL9"/>
    <dbReference type="GeneID" id="19137281"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33724"/>
    <dbReference type="eggNOG" id="KOG2632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084816_0_0_1"/>
    <dbReference type="OMA" id="NTYPIVH"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="60"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="262" mass="29393" checksum="688CF62899EA38E6" modified="2013-05-01" version="1">MPAPSLPQFNPARIRSYILRLPFCTKVVVAAIVGLWIATIPFPWIRDVGRLEPAKMDFTQMHRLNLFPVLHWNFIHMIFNLFAVTPLIERFESEYGTLVTLALFTGPFGTIPGGVYTLLEKFVLRSNTAVMGASVWVFLLLSAEVMKTQKTNPFFSVGPYKIPTWTTPLILIVITSILVPYVSLVGHLCGAGLGYLWATGYIKFLVPHEKILRWIETKLNLLGRLPHYVSVDQKTYGRYGVLPTTGIPLGPRSPDVGQRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2RVG4</accession>
    <name>M2RVG4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UEV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_194446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705494.1">
        <property type="nucleotide sequence ID" value="XM_007707304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RVG4"/>
    <dbReference type="STRING" id="665912.M2RVG4"/>
    <dbReference type="GeneID" id="19133896"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_194446"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017548_2_1_1"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="503"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD59068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="63486" checksum="1BB75EEC3053BC1E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2RWS5</accession>
    <name>M2RWS5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_126791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_007704567.1">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Bradshaw R.E."/>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
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    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
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        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
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    </dbReference>
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        <location>
            <begin position="56"/>
            <end position="192"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="220" mass="23910" checksum="DC2FAB057B9A652E" modified="2013-05-01" version="1">MASNNNKTTPKITSLTELPSSEAKWIKLQKATYTDAHGASRIWEIASRKTTGSAGVDAVAMGNIIYHPSKPPSTIVVIQFRPPVGGFTVEWPAGLIDKDETPEEAAVRELYEETGYKGTVVSTSPAVAADPGMTSANLCLCMVEIHLNEGDPEPEQHLDEGEDIQRVNIPVAELYTRLEEFAKEGYVIAAKLYHWAAGAQYAIDHPELFQKAGKKAEGSL</sequence>
</entry>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_104431</name>
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    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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            <taxon>Pleosporales</taxon>
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            <taxon>Bipolaris</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445662">
        <property type="protein sequence ID" value="EMD58210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S762"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104431"/>
    <dbReference type="HOGENOM" id="CLU_3055907_0_0_1"/>
    <dbReference type="OrthoDB" id="3701958at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="54" mass="5990" checksum="3DB829E6F884910E" modified="2013-05-01" version="1" fragment="single">VRVVICRGRFGFGSGPSSLEQDVTEGENPLLPCKAPSTSRVVWECSSKWEVNFF</sequence>
</entry>
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    <accession>M2S780</accession>
    <name>M2S780_COCSN</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_92614</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703072.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19141457"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92614"/>
    <dbReference type="eggNOG" id="ENOG502RZ5C">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
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        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="370" mass="40597" checksum="9788905391C52BB9" modified="2013-05-01" version="1">MIPQDVIEKALSRAQESASHSWEHSTVFEALLEYRNPSYSVFSPDPFPNGATPRLKIQDIDALRYVRPLIRTDTPTLSEDNGSSADPTSLCLPTLLLAHSPSLPPSTRTTYSTALSRQLDQLLKETPRFPNGALSHRSAYPSLWSDFIYMAPPILAYIGVSNRNVSLICESVRQCKLYCEVLGTPSGSWRHIANLSPTTAEKVKQDDGAWSTSNAWAAAGMARVLATLLHSPFAAQTKAEQVLLVEMIKGILDAARAVDTHPSRLLRNYLDDESAFVEVAGTALMAATVFRIAGLKGAGAVFGCEYTEWAREKMRAVAEHVDVRTGVAAPVVNSLREREEMPLGEVNPEAQAFVVLLFAAWRDWSQAQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7I2</accession>
    <name>M2S7I2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_204479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445657">
        <property type="protein sequence ID" value="EMD58335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705994.1">
        <property type="nucleotide sequence ID" value="XM_007707804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7I2"/>
    <dbReference type="STRING" id="665912.M2S7I2"/>
    <dbReference type="GeneID" id="19134296"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_204479"/>
    <dbReference type="eggNOG" id="ENOG502SK7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654004_0_0_1"/>
    <dbReference type="OMA" id="GFYWPSA"/>
    <dbReference type="OrthoDB" id="3701586at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024772" evidence="1">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="417" mass="45690" checksum="DE1251C56EE04524" modified="2013-05-01" version="1">MIPNNLILLSALAASALAAPSGVVKRQSNEDNLWQVPVRRDPKEPGQDRWTQINSVVTPIDKAADDNRKFSYYPSLYNMGGALFLLFSGAPKDVDGMGQDVRISYSTDGKWSKPEIAFPAALLPNQTTIETSEYYCKRGIPQRALQALSIVYIGGGESDATYYAVAQSSDNVCPGHTESAGRIARKLRRDPLAGETFSGDPCWIETNDYTGSHEWAETVYGTKYQMKVCDDKEKILAALSNPQSVPSQATSLFNEPLVAADGKHNVSYPTNAIYLPGSSDTGRYMRFWADVSMRNKTGNAFIQQTNIYSSYKAWFGSSEGSSQLRVYVSNSGMNSDSSQEILTVATSRGDDLAFRNIGILRSDSEEKVPVGTRPIYGSDLAGFYWPSAVFQGDKLVVAYSENKANIQVSTINFADLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7S1</accession>
    <name>M2S7S1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_176614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705880.1">
        <property type="nucleotide sequence ID" value="XM_007707690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7S1"/>
    <dbReference type="GeneID" id="19133044"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_176614"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042557_2_0_1"/>
    <dbReference type="OMA" id="QCMGRYV"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20615">
        <property type="entry name" value="CYP_GliC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="507" mass="58272" checksum="BC54E876A5B5688A" modified="2013-05-01" version="1">MKPKHLAWGLSITTLFTVALLKAISLSQNVLVNLISSILNWYLHWRYPIKDVDGTKNLPSLPYVWPNGNGDAAKFLQGRENGEEWRKKLGSTYRIWSGSTPEVVISEPEHLKELFKDSDQHYKAVNNDSGYLMSQLLGQCVGLLSRKSWQSLRSQVEGPFTHVAIANDAALIRAQTRKFVEQLSNTGDFRNGIFDPAKDINFYPFFVVATLLYGDLDAEDVQWLRKIAPLRQKLFTYVISGGLARFSVSRFLPTTANRLLHEFQQEWSCFNESIYEKAKARGDITPMTKLWEDSKEGRIDQVQLLQTLDESLFANLDVTTGAISWNFIYLASSPNDQARLVEEIKRECGPDDIHWDAYIARSDTFLASCINESSRLRPVAPFSIPQAPPTNRRIGKWMLPGRTMIIVDSYGLNIRNPFWGEKSQEWIPSRFLNIKPSQLRYNMWRFGFGPRQCMGKFVADRMLRSIVASIIRDWQLQLRPEDANTDFTVNPDEWITHPDIRLICKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7T2</accession>
    <name>M2S7T2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_120374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701422.1">
        <property type="nucleotide sequence ID" value="XM_007703232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7T2"/>
    <dbReference type="STRING" id="665912.M2S7T2"/>
    <dbReference type="GeneID" id="19130446"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_120374"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008679_1_0_1"/>
    <dbReference type="OMA" id="HKAGPPF"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">ND90Pr / ATCC 201652</strain>
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    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705356.1">
        <property type="nucleotide sequence ID" value="XM_007707166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8G9"/>
    <dbReference type="STRING" id="665912.M2S8G9"/>
    <dbReference type="GeneID" id="19133885"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_194314"/>
    <dbReference type="eggNOG" id="KOG3023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055657_0_0_1"/>
    <dbReference type="OMA" id="CTDILPR"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000026">
        <property type="entry name" value="Gamma-cysteine synthetase regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="75"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD58885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="316" mass="34569" checksum="BC097C3904FC7524" modified="2013-05-01" version="1">MKLILSTSNIMSGGPSVIRRPLFEKSNTELTSSLRANFSAHQPSPPPSKPNHRTWTTATDSALYVPTHTPSPLTEPRESYDITVKLFYLPNIPADRRCAQTREAIELVLKELGTSSIDLLIVSFPGISFDADDEESDFEDDDPPSPPSATQSTSENTAGDCLDAGVPPEDLETMIKTWHALEKLQSEGLVSKLGIAEFGVARLTRFLERTNIKPSVNQINVRDCCVVPKPLILYAKQQQIELLTHNDCTNILPRGTLRQILGAGENGSGVLAGEGNEEGLKGDVEPQWVVKYTAVVKDRGVVENKGYFAVAELRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SA51</accession>
    <name>M2SA51_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_199593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700050.1">
        <property type="nucleotide sequence ID" value="XM_007701860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SA51"/>
    <dbReference type="GeneID" id="19134102"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_199593"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OMA" id="MAIIVSC"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="89"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD64183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="574" mass="64248" checksum="F57DC83D42A9A36B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB55</accession>
    <name>M2SB55_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_199906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700286.1">
        <property type="nucleotide sequence ID" value="XM_007702096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SB55"/>
    <dbReference type="GeneID" id="19134116"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_199906"/>
    <dbReference type="eggNOG" id="ENOG502RI5K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073660_0_0_1"/>
    <dbReference type="OMA" id="ESWYRTT"/>
    <dbReference type="OrthoDB" id="3684889at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="311" mass="36038" checksum="B2DA114277251D98" modified="2013-05-01" version="1">MDSDSESELMENPRDFAQVLQHLLMQQIQEYQETQARKPKEPSPIVEEKKSALRPLSPRECHSLCTSVHQALPREIRDMIYGYIHAHETIYVGPEYFEKTTVPCESDAKAHYWSAQYVGTEMQREMIESWYRTTLFYFYDKGNNSRVIERFLVTDRWGHDIKPQDLICRARVELSVEERLHTKYKERPCCVVKDAGGKLTSVFKLFHQLPNHVEFFMRVQTYDAPHTGCMSASELCGAIHALVEELVTLHSMGHRVVVQWPDLNNVELSWKNGAFKASEWTKQLVQAAPMKLNYKYAMPESSAGDVSQTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SC77</accession>
    <name>M2SC77_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_315977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699453.1">
        <property type="nucleotide sequence ID" value="XM_007701263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SC77"/>
    <dbReference type="GeneID" id="19136471"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_315977"/>
    <dbReference type="eggNOG" id="ENOG502SURR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_754680_0_0_1"/>
    <dbReference type="OMA" id="FRHGIFP"/>
    <dbReference type="OrthoDB" id="5427732at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025468" evidence="2">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="376" mass="39034" checksum="520EA49A7B1C03AA" modified="2013-05-01" version="1">MRSFCQVAVMALPLFSAIAATEPKNVADPPKTIYATAQEAFQDLLNALPEESLQAALSNLKDFKNGIFESHHRGVENIHSNNPALASKLIVDAVNDLRKRQTPSNGTNSATTASNPPESIQNSTPAPTTSDNLQPPETSSAAPPPPPPPGTSEASADTVIQTQTQTQTQTQTQTQTQDQTQTQTQTQTQQQTTTAVSTTTQLRPAIIPVESTVTKDGKTIVQTTAVLSEVTASVAVTVVRTNPAGSTVTETENRPAVVKTTTDRAGRTTVTTSAVNFAPTAGQVTSTTDSRGSVVLTTLTPGGGLVSSIKLITTTDAQGRQSTMTTYAFVDPVQATGAANSPNAPGDDKPSLQTGAAVVNGAQYAAVGLGALAFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SD95</accession>
    <name>M2SD95_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_35348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698283.1">
        <property type="nucleotide sequence ID" value="XM_007700093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SD95"/>
    <dbReference type="GeneID" id="19138236"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35348"/>
    <dbReference type="eggNOG" id="ENOG502RF66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_963135_0_0_1"/>
    <dbReference type="OMA" id="KWFDQPE"/>
    <dbReference type="OrthoDB" id="5086080at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF7">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32178" checksum="59C7146A2D2DCB8E" modified="2013-05-01" version="1">MDHEPKNAAPTQIYITQKRNRPASEQECRERKRAVDRQAQRSLREKTKIHIAKLERTIEILRNKDRNDTTATLLSEIDALRAENEQLKHTIESVKSLVGINVVSQDILPAKPGPGTEDANYSPTVAAVGHNLPEPPTTSIDRDPQPSPLPDMNQSTSIERTTSEDEQKWFDQPEFPDQTDFFQPSPSPNGPTVINQSTTTVIDLDGMTITPDPDELAAPDTNRELTHSPGLQLPPTFAPKKHAEETLQELLEAAPFSSMMQEIMGAKMFLSLPHHSPHRPPSPSVTLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDE1</accession>
    <name>M2SDE1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701901.1">
        <property type="nucleotide sequence ID" value="XM_007703711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJR9"/>
    <dbReference type="STRING" id="665912.M2SJR9"/>
    <dbReference type="GeneID" id="19130484"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_121368"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000690_2_2_1"/>
    <dbReference type="OMA" id="EWRLDQI"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF128">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="705"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="705"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD62565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="844" mass="97389" checksum="8815CE82161BFDA4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLC1</accession>
    <name>M2SLC1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger double-stranded RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_80038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695712.1">
        <property type="nucleotide sequence ID" value="XM_007697522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLC1"/>
    <dbReference type="STRING" id="665912.M2SLC1"/>
    <dbReference type="GeneID" id="19140762"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80038"/>
    <dbReference type="eggNOG" id="KOG4727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067237_2_0_1"/>
    <dbReference type="OMA" id="VDHRRKW"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger double-stranded RNA binding" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="214" mass="24396" checksum="BED2CB10D5F40D3B" modified="2013-05-01" version="1">MSGKAGAYGTTGGGDTDFRKTWDRDEMAKKAKEREAKEREEGKERYEAKMAGKSYRRRASTPEDLKQTEARAERIDWSKMIGKQTLTSAAAAVGKRGRGAGAYCGACDLTFKDNIQYVEHLNSKQHLIATGQSGEVRRATVQEVRDRLRYLKRKQDEAKILDVIDLDSRLAMNREQMEKDAEEKRRLRNEKRRAKKKTDSNAMEWKVEGDGVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SM59</accession>
    <name>M2SM59_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_104369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445660">
        <property type="protein sequence ID" value="EMD58231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706081.1">
        <property type="nucleotide sequence ID" value="XM_007707891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SM59"/>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="204" mass="23132" checksum="81CC64B43117DADB" modified="2013-05-01" version="1" fragment="single">VRSVTNKDVGLRVLREAPIQAQSIDIVAVHGLGAHPDDSWCKNAGTAEEPRWRNWLIDNDMLPVVAPNARIMRYGYESQWFGKEAMQQSVSTVAERLLRALKRERKDVPFRPLVFVAHCFGGLVVLKALLEAEQYPNEWPGLFSSTTGLVFFGTPFRGAEGMDQMEMLEAARREYHEDQLQPAALELLKEDARPDKQDSDRLLL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="EMD68968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007695912.1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD68968.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="226" mass="26150" checksum="B1B9FAE3BB0228C4" modified="2013-05-01" version="1">MEVFFPTLDRFETVFSDNVVPDGAAHMRSSVSGEMQQHFYWGSMRDRLAAAQTDHLIGERAFPKSSTERVEKGDTRKQRITVPGRKNLAVIRSGQDWSNTNPSERKRYLETMHPVLTKGMEFLRDEGEEIGCISNRFMECMHKTSPEQNTERTFGLSYFDDLKSLEGWSKHHKTHLDIFGRFLQYASELQSNVSLRLFHEVMVLEPEQQFFEYIGCHDTTGMLASV</sequence>
</entry>
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    <accession>M2SPH9</accession>
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        </submittedName>
    </protein>
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            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="247"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58652.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="791" mass="86916" checksum="DD05BA47E4CFC814" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQK1</accession>
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        <recommendedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
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        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
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        <property type="protein sequence ID" value="EMD69523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="665912.M2SQK1"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_155694"/>
    <dbReference type="eggNOG" id="KOG3730">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:triglyceride biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
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        <property type="entry name" value="GPAT/DHAPAT_C"/>
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        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="206"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="844" mass="94530" checksum="82686917632CDFB0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQT9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_155772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694881.1">
        <property type="nucleotide sequence ID" value="XM_007696691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQT9"/>
    <dbReference type="GeneID" id="19131719"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155772"/>
    <dbReference type="eggNOG" id="ENOG502SM8K">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_044491_0_0_1"/>
    <dbReference type="OMA" id="ENRWMLQ"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="381"/>
        </location>
    </feature>
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            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
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            <end position="103"/>
        </location>
    </feature>
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            <end position="118"/>
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        <location>
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            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="466" mass="51184" checksum="FFD3EE1C5E57C482" modified="2013-05-01" version="1">MRGVQSALFHYASCAPCTGYSDGRKRRKAAKEARKLREKLELEQPGAYYHPEPTGTNAYWSEEIAMGPGPPPRRARKTNTTQRTGSRGLPTRGTQSSTLSKGGSSLDVDHAAENRLSDDTLDDDDETWNHKRYQREDEDLWGYDDHSTALEHTMTGSSVGGGGYQLQRPNVSRAGSYYVARVPPVNELHPPVVSLPSPDPSENKWMLQPPPKASVMAGKERAKNRSRSGSGASSRVELSLGRQVSTRQLMQKLERGQTPDRLTNSPNGSYSNLAHGRCKTPQARPPSATSSSPNRKRRDTAMARDLAIARTDTASTQHSSPDPSDITVRGSSTLSVDVQVLRTHQSRPVLSTVSSSNSGQDENTLPEKPKPAYRSSTTPDLSSLNCLQDLVSSQALLTSRFVSAPLVEAKIRLPPSEEDIAARARKDKTLRKKEDDDEVDAIVNVPFDRESGPPEKDPAFRWSVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQZ7</accession>
    <name>M2SQZ7_COCSN</name>
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        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_106463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694930.1">
        <property type="nucleotide sequence ID" value="XM_007696740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQZ7"/>
    <dbReference type="GeneID" id="19129999"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_106463"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_1_1"/>
    <dbReference type="OMA" id="QNNFGIV"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF28">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025261" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="494" mass="53617" checksum="DAAEAB1049340F46" modified="2013-05-01" version="1">MRFLALSSITWLASTAAAYSYSCNACQELSSALPNNTFYPSAQTYNASIQSYPFLQLRLHPSCIVRPSTSQDVSTAVSILAQTNCTKFAIKGGGHNANAGSNNIDDGVTIDMQSLKKVEVAKGDQVVQVGAGALWQDVYDTAEKRNLTAMGGRIGVVGTAGFLTGGGISFLSPEHGWACDAVVNFEVALANGKLVNANSTSHSDLYAALKGGQNNFGIVTRFDLKTYPARSIWGGRTVYGPNATAALLSAYTDFKSGEYDPYAAGWVTVRYNHTAGTFNPVSIMWHTKPTEKPGALKAIIDVQPQVMNGRVEAPISEHTRNASRQVSANPQRTIWATTSFKISPTIMHSIHDMWRKIIPEISEQYASAKPIAEITFQALPAPPRNGTAPNSLGFGPEETPEKDLVFLQIIFTFENAAAADGFEEGLIDLVKLVEDITKKEGVYHPYKYLNFAASFQDPLGSYGKKELRKMYKVADKYDPQGVFQTHVPGGFKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR00</accession>
    <name>M2SR00_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_313785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699305.1">
        <property type="nucleotide sequence ID" value="XM_007701115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR00"/>
    <dbReference type="STRING" id="665912.M2SR00"/>
    <dbReference type="GeneID" id="19136427"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_313785"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_1_1"/>
    <dbReference type="OMA" id="DKWGIPT"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10420:FF:000007">
        <property type="entry name" value="5-formyltetrahydrofolate cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="167"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD64715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="248" mass="26820" checksum="45E70CEDF495DFA8" modified="2013-05-01" version="1">MAGSLAAVKKELRKKIRTILSQLPDAAAASQTANATATLLAMPEYQAARRISVYLSMPGGEISTSDIVRNALGNGKKVFIPYTYTLDTPDQGQPKSIMDMLELHSMTDFDSLKPDKWGIPTPSTESISSRANCFGGTGVTNGKTNGIKDGLDLIVMPGMAFDAQFGRLGHGKGFYDFFLTRCHHESRMPFRGKNYWYSVCGGLTDHVKVGLALTEQLLPPNESVPMDSSDFHLDALITGAGELRRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR54</accession>
    <name>M2SR54_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homoserine kinase</fullName>
            <ecNumber evidence="4">2.7.1.39</ecNumber>
            <ecNumber evidence="5">6.3.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">COCSADRAFT_32410</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4"/>
    <dbReference type="EC" id="6.3.3.1" evidence="5"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694286.1">
        <property type="nucleotide sequence ID" value="XM_007696096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR54"/>
    <dbReference type="STRING" id="665912.M2SR54"/>
    <dbReference type="GeneID" id="19136761"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32410"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021258_1_0_1"/>
    <dbReference type="OMA" id="CLMEERH"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000016">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="20">
        <location>
            <begin position="66"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like N-terminal" evidence="21">
        <location>
            <begin position="416"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="22">
        <location>
            <begin position="535"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMD69733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="710" mass="75977" checksum="8369D3A6C4091F65" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRE4</accession>
    <name>M2SRE4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_315444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699411.1">
        <property type="nucleotide sequence ID" value="XM_007701221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRE4"/>
    <dbReference type="GeneID" id="19136456"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_315444"/>
    <dbReference type="eggNOG" id="ENOG502RZS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_1_1_1"/>
    <dbReference type="OMA" id="MTDGHSA"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        </citation>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
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                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704549.1">
        <property type="nucleotide sequence ID" value="XM_007706359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRR6"/>
    <dbReference type="GeneID" id="19133864"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193665"/>
    <dbReference type="eggNOG" id="ENOG502SHMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546286_0_0_1"/>
    <dbReference type="OMA" id="CCINIAP"/>
    <dbReference type="OrthoDB" id="3788364at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946:SF4">
        <property type="entry name" value="COAGULATION FACTOR XI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025743" description="Apple domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="499" mass="50907" checksum="52FD6FD8FC807ADF" modified="2013-05-01" version="1">MSSALFLASVLALRASSLICPSLPTCPDDNECTFSSNGADFKVSCATDFYGGDMGRVYAATVAECMKICASADGCVALSYVGTDCYLKNALNGGSTSAGVTGASIISRVNPTPPSSSPAGPQQPCPASISCPDNNGCLSSDSTTGRSFTLSCGIDFYGGDLKLEWTDGLEACSAACAANSECVAASFVGNSGSSGPCYLKSKNLGPVADSRVNGFSVKSLSAPATPSSTPATPNTEDITKLLNTPEDIQFCASYINYSPPVETLRTAATISAVTRTTTTNLVTSTPSAVTLVETVVVSGETTTVASTETVVITTTVQGNLKKRLQATPAAALETPSVLQGWSPQDISAACSKVATFTSTTTLTTATETVYTATETSSTTTTTVAPTPTITMATTSPLIRTVSVTSTTLATVTSRIPVLEQPQCDSRPVRLCCINIAPWSTNSGVWGGICGYTPSNPAELVGARCITRPASGQCPAGTSQACCRGTVPGQCALGTQCARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRW8</accession>
    <name>M2SRW8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_36369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699153.1">
        <property type="nucleotide sequence ID" value="XM_007700963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRW8"/>
    <dbReference type="GeneID" id="19138716"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36369"/>
    <dbReference type="eggNOG" id="ENOG502SYD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1428675_0_0_1"/>
    <dbReference type="OMA" id="MRKGKWC"/>
    <dbReference type="OrthoDB" id="5281164at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="190" mass="22013" checksum="04468C8B6E72D5CF" modified="2013-05-01" version="1">MLTAPILRLPVELHSEIIKLLDIRDRVNLASTSRYFRFLIPAPTHSELLVAEDSAWAKSSQLYACKGCLNFWSWASFEDSMRKGKWCRSGTLASSRLCLKCGVNSALYTPGVHLRVCNRVHVLCAQCRRLTDQIGRHGMCTACSPDMPRDHQSQYFDDEDDWTYMKDRMSDCNHMQEFSDWPEEEHLSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRZ9</accession>
    <name>M2SRZ9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_26005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699059.1">
        <property type="nucleotide sequence ID" value="XM_007700869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRZ9"/>
    <dbReference type="STRING" id="665912.M2SRZ9"/>
    <dbReference type="GeneID" id="19135414"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_26005"/>
    <dbReference type="eggNOG" id="ENOG502SH47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013296_2_0_1"/>
    <dbReference type="OMA" id="SMRYQMA"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF82">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="267"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="652" mass="72915" checksum="8DA455CDFB6B3A4E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS41</accession>
    <name>M2SS41_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_175469</name>
    </gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698519.1">
        <property type="nucleotide sequence ID" value="XM_007700329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSR4"/>
    <dbReference type="STRING" id="665912.M2SSR4"/>
    <dbReference type="GeneID" id="19141146"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86882"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_3_1"/>
    <dbReference type="OMA" id="DQVLMDH"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000023">
        <property type="entry name" value="Hsp70 chaperone (BiP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="571" mass="60932" checksum="477E3CFE72AF4266" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSU6</accession>
    <name>M2SSU6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_85983</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698535.1">
        <property type="nucleotide sequence ID" value="XM_007700345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSU6"/>
    <dbReference type="STRING" id="665912.M2SSU6"/>
    <dbReference type="GeneID" id="19141082"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85983"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_1_0_1"/>
    <dbReference type="OMA" id="FIQHCQA"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="8"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD65365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="398" mass="43784" checksum="41B79C8DB996E46E" modified="2013-05-01" version="1">MNSATSGYKNVAYFVNWAVYGRNHHPQDLPAEELTHVLYAFADVRDTGEVFLTDSWSDTDKHYAGDSWNDVGTNVYGCVKQLFLQKKRNRKLKVLLSIGGWTYSSHFVTPASTAQGRAKFASSAVALLANLGFDGLDVDWEYPANESQANDMVLLLQETRRALTAYSNENANGQHLLLTIASPAGPKNYNIMKLAQMDQYLDFWNLMAYDYAGSWDNTSGHLANWAPSMSNSNSTPFSTTQAINDYVAAGVPASKIVLGMPLYGRSFANTDGPGKPYQGVGQGTWETGVYDYKVLPQAGAQVYTDSQITASWSYDPNSRMMISYDTPEIVAKKTQLIRDNGLGGGMWWESSSDKKGSESLVSTFVNNIGGIGALDQSTNLLSFPTSKYDNLRAQFPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST23</accession>
    <name>M2ST23_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_99931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704418.1">
        <property type="nucleotide sequence ID" value="XM_007706228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2ST23"/>
    <dbReference type="STRING" id="665912.M2ST23"/>
    <dbReference type="GeneID" id="19141883"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99931"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OMA" id="ASITWHH"/>
    <dbReference type="OrthoDB" id="3676828at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="52176" checksum="0146E5043B83393A" modified="2013-05-01" version="1">MLQPLQNGSRVLEYLDNTPNQGIFRALDLLNREVLVITSPEFIKEILQTNAYDFRKMANVQNFMKVLLGDGLLTVDGEEHKQQRKALNPAFSAKHVQKLYSVFYSKTREMITYIKEDMNTSQGQKGISVDITAWVNRAALDIIGIAALGIDFNSLANPTNELSRAYQVIFEPDNTSNIIFLLSIFFTTWAVKLLPLKKAREIRAGSAYVKRYIEEVVTRKTQEHDDEKAPHKDILSVASQYGNLSTNELVNQARTFLVAGHETTATAMQWALYTLTRPENLHVQQRLRDEIHKQLPPLDSEQEISAYTLGKNLPYLDAVSKECLRVYGPSPFSRRTAVRDTVLCGIPIRKGTSFLIPNWAINKSKKLWGERAREFDPERWLHGNQAPNGGADALAFQTFSSGTRGCIGKSFALAEFKIMLAGLVGTFEITKAADEKEIETEWAIIARIYNGFKVNLKPVSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2STD4</accession>
    <name>M2STD4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_151285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704278.1">
        <property type="nucleotide sequence ID" value="XM_007706088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STD4"/>
    <dbReference type="STRING" id="665912.M2STD4"/>
    <dbReference type="GeneID" id="19131553"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_151285"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_0_1_1"/>
    <dbReference type="OMA" id="PSLYAMM"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="269"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD60032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="457" mass="49621" checksum="00FF9CA75C756D14" modified="2013-05-01" version="1">MVREKQPVYVLGVGMTKFIKPRGKVDYPELGFEAGVKAMLDAHINYDDVDQGVACYCYGDSTCGQRVFYQFGMTGIPVYNVNNNCSTGSTGLYMGRNLIAHGAADCVLVVGFEKMFPGSLQTFFQDRANPTGTSGLMMKETRGVTNAPGAAQMFGNAGREHMEKYGSELRDFAEIGRINHAHSKNNPYSQFQDEYTLEQVMKAPMIHEPLTKLQCCPTSDGSAAAVLVSQEFLDKRPELKDQAILIAGQRLATDTPSLFNRSAIELVGYSMSELAAKDALAEAKVTPDDVKVCELHDCFSANEMVTIEALGLAPKGKAHELIRQGGITYGGKVVINPSGGLISKGHPLGATGIAQCAELVWHLRGWANNRSVKDTKVALQHNLGLGGAVVCTVYKRHDGSAAMDKSDEEISKITGLGYNPATVAKGFTKEQVDSVRSKKARSEWALQDTQQKVESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU10</accession>
    <name>M2SU10_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PNG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein png1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_309673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698833.1">
        <property type="nucleotide sequence ID" value="XM_007700643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SU10"/>
    <dbReference type="STRING" id="665912.M2SU10"/>
    <dbReference type="GeneID" id="19136354"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_309673"/>
    <dbReference type="eggNOG" id="KOG0909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031058_1_0_1"/>
    <dbReference type="OMA" id="AWDKPRL"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="7">
        <location>
            <begin position="230"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="441" mass="50217" checksum="4014E311A0318D3C" modified="2013-05-01" version="1">MDHNTRAPRAATNAMDTDRLAAELTEQFRHVLSTKRINDLTSRSSQSRSSSPAPRDFGSPQPPPSQAAPPAYSSIKNIPLVPEPPRDARSLRFKNMLHSLSNMPVRWENPGLLDEALRVIPLEQIYNEAEEESQILQAEAESMGAGKKAAWGYQDCVVRALLRWFKRSFFSWVNNPPCSRCYSPTVAMGITPPLPDEQARGASQVEAYRCSNDGCRNYERFPRYNDAFVLLQTRRGRCGEWANCFSMLCRAVGSRVRWVWNAEDHVWTEVYSVHRKRWVHVDACEEAWDKPRLYTDGWGKKLSYCIAFSADGAMDVTRRYVRDAKHAAERNRAPEAVLLYIMDEIRATRRANMSKQDKFRLQGEDIREAKELRAGVISSIAQAVCKLRPEDIINGQVTRRLDADAQKALEGRLSGNSAWIRARGEGGQQQNQQDPRNQHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU70</accession>
    <name>M2SU70_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_355236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698883.1">
        <property type="nucleotide sequence ID" value="XM_007700693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SU70"/>
    <dbReference type="STRING" id="665912.M2SU70"/>
    <dbReference type="GeneID" id="19138351"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355236"/>
    <dbReference type="eggNOG" id="ENOG502T2UE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_1_1_1"/>
    <dbReference type="OMA" id="HDIETHW"/>
    <dbReference type="OrthoDB" id="3778131at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="29"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="195" mass="21898" checksum="20CF9BE33FBDAA7B" modified="2013-05-01" version="1">MSSRSDVLHHSALTRPENGLWSRKSRPDLSHDYVTSPKADLRETTNMYYLEVELPGIGGPHDIETHWLDESTLQIKATIHKTNLEAMWCDDKSDDKPQQQAIYAGGTDNKVDKKISSKENILGQRRGRQGSHVASTMNFWLNERKAGVFMRNVCFAVAVDIDSVQARLSEGLLMIMVPKKDAAALEAKEIFIESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUL8</accession>
    <name>M2SUL8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">60S ribosomal protein L7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_148886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD60761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007704968.1"/>
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    <dbReference type="STRING" id="665912.M2SUL8"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_148886"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_0_2_1"/>
    <dbReference type="OMA" id="IVEPWIA"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="29421" checksum="BDA2A83F2D95389D" modified="2013-05-01" version="1">MSTKSTVPTQSDITLVPENLLKKRKSQEKAREERAIATREKRDKNKKKREVIFTRAEKYVKEYRDAERERIRLSREAKKSESLYVPEEPKLAFVVRIKGINKIDPKKRKTLQLLRLLQINNGVFIKLTKATMEMLKIVEPFVAYGYPNQKSVRELIYKRGYGKVDKQRVPLTDNEIIEENLGKYGMICMEDLIHEICTVGPNFKAASNFLWPFKLNSPTGGFRKRKFKHYIEGGDLGNREEKINELIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWG7</accession>
    <name>M2SWG7_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_239957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703481.1">
        <property type="nucleotide sequence ID" value="XM_007705291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWG7"/>
    <dbReference type="GeneID" id="19134978"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_239957"/>
    <dbReference type="HOGENOM" id="CLU_2359553_0_0_1"/>
    <dbReference type="OMA" id="SSHQCFC"/>
    <dbReference type="OrthoDB" id="3688590at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="93" mass="10219" checksum="367B0875D421B01D" modified="2013-05-01" version="1">MGRDTRRQYSSSHQCFCVLPSRGHLLQRLYDWPGLHVVVTIAVLPVASLLHDSQRLCPVVRPGVCGAHVGRASAKVVLRGKTTRAMPMIMNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWM3</accession>
    <name>M2SWM3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_149908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703528.1">
        <property type="nucleotide sequence ID" value="XM_007705338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWM3"/>
    <dbReference type="GeneID" id="19131516"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_149908"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_3_1"/>
    <dbReference type="OMA" id="KHWTIAV"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025429" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="83"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD61237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="390" mass="42351" checksum="886ECF7B13136958" modified="2013-05-01" version="1">MTGKLALAILASSACALVAEPRSAAYSVDALAAAPRSFDFEAEFRKLRSRHPTTENVEKRQADIAGQQEGSVTVLPNDPGVTYLTPTIIGNQTFNLIYDTGSADLWVFGNETSQMQGPDKTYYFPSSSAQLLPNYNWSITYSGGSSANGIVYTDIVKAGPVVAEKQAVEVATYVPSYIDSDGLMGLCFGILNQVKPVQQTPFFETVAPTLKKKVFAANLRPEGNGSWDFGYLDESKYIGDITYTPVVGNMKHWTIAVGEYGAGNKTFESATIGNTTVDSGSPLIYLADQAVANYYSQVPDYELTLGGSNTFPCNATLPDFTFKIEDQTFSVPGQYLNFGVSDPLRKRCAGVIVGKRTLRNSLFGSIWMKNFYVVHNIEDSIPKLGLAPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZK6</accession>
    <name>M2SZK6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Blue light receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_38328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701592.1">
        <property type="nucleotide sequence ID" value="XM_007703402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZK6"/>
    <dbReference type="STRING" id="665912.M2SZK6"/>
    <dbReference type="GeneID" id="19139226"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38328"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024414_1_1_1"/>
    <dbReference type="OMA" id="WLDATEM"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD62381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34291" checksum="3DC452CEE0259CA9" modified="2013-05-01" version="1">MPFATCTSQNWAEHATQYLADFLHVLSPEGRLVYISPSCSSITGYEPADLLGCFIGDLVHPDDNILITEFFRTIFFTRTTRVIYRFLKKDKTWLVLESSFTPSTQVPICRTESNPSPRFRPHVVVLARPYLTKHKMILDSFLEHIVLYEKLQQQIRDLKNEERRDEAEALTNAQNERPFSVHQGVMSEVSQSSQIDSNNFVESVAGPGSERAVVGDLGIPILATLSRGHERPASSMRRKKRPKNEDPLICHSCATVQSPEWRRGPDGLKTLCNACGLRWSKTIGATMMEKVDTPRKRNEAGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2T022</accession>
    <name>M2T022_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_342617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701766.1">
        <property type="nucleotide sequence ID" value="XM_007703576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T022"/>
    <dbReference type="GeneID" id="19137554"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_342617"/>
    <dbReference type="eggNOG" id="ENOG502RJ2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065176_0_0_1"/>
    <dbReference type="OMA" id="TFAKENW"/>
    <dbReference type="OrthoDB" id="3695611at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="302" mass="34136" checksum="69B28215A7FDE786" modified="2013-05-01" version="1">MAPILRPRPTKGKNQPPPNSPSKGSAASAPKPPKETSTASTRHSHPRIPTQGSPSVSQPRHTQPSPSPRAIAPNPPNPAPAPSSNYNHYNPSTGGYSTLLQPQQSTRASQGRLSSSHNTARTTSTARTTTRTTSNAPTSTGTTSNAPATTRVTPTVFNTTRTTSIAPTSTRNVPTTPTVEELRQRRKARIQELCADISASYRHFLEILQLIPLDWSRDERPDPYLKSLLANRMMPQDRECELALAITFAKENWWHFATWPEDVKKYAELERDKRRREWEQRQREWERRHWEWVEKREKEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0Y4</accession>
    <name>M2T0Y4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_161430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701188.1">
        <property type="nucleotide sequence ID" value="XM_007702998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0Y4"/>
    <dbReference type="GeneID" id="19132098"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_161430"/>
    <dbReference type="HOGENOM" id="CLU_829099_0_0_1"/>
    <dbReference type="OMA" id="NADLACF"/>
    <dbReference type="OrthoDB" id="3726939at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="324" mass="36390" checksum="2AFDB8A8392FBD9E" modified="2013-05-01" version="1">MSVYGGSVLNWTSVTGCVGIPNLQLKMINDPEREDAIGTIYNEAEPPSRLRLMIGTYKNQTICEVRTEYVQAQIRCSRAADNADLACFVERMRHDPSFAGSGNLMALDIGLNYTILQQIPWTFASSHPGEPSILEMWLKDPTTAFNTDEFLNIGNVEFWYKDISLGLFADRLAMVLNTHLRASLQMSYIVGSDGLALKNESQSWAQANGTWAEKISLRYQLNKVWFLLYLLSAIVRVICALANIVLRTIIHIPDFLDSVSTLTRDSNYIHVATPGSTLNGIDRSKLLRDKHIMVQDVQPENEVGRLALSDSLRSISVQQDRIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1D0</accession>
    <name>M2T1D0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_79833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695974.1">
        <property type="nucleotide sequence ID" value="XM_007697784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1D0"/>
    <dbReference type="GeneID" id="19140750"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_79833"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OMA" id="PDHDWST"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="335" mass="38064" checksum="1601DF5D6611C0A7" modified="2013-05-01" version="1">MQYARLGTSGVKTSRIILGCMAFGSPAWEGSSWTLPEDESMKVIKRAWDLGINTWDTANTYSNGESERILGHAMKKLNIPRSKVVIMTKLYYPVMDDESRPQPPDSYSQQLVNQMGLSRKHIFDAVEASLERLQTSYIDVLQIHRLDRDTPPKEIMRALHDLVCIGKVRYLGGSSMYTWEFARLQYTAKLNNWTTFTSMQPFYNLLYREEERDMIPFCRSEGIGIIPWSPLARGLLGRPVGTTSSRNEADAKTKKWFGDAEPEIIRHVEELSKTKGCSMASVATAWVIKKGCSPIVGLTSVERVDQIMESLGVELSDEECKYLEELYRPRSVQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1S0</accession>
    <name>M2T1S0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_182268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1S0"/>
    <dbReference type="STRING" id="665912.M2T1S0"/>
    <dbReference type="GeneID" id="19133350"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182268"/>
    <dbReference type="eggNOG" id="ENOG502QW2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280886_0_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="9">
        <location>
            <begin position="86"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="638"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="974"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD62972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1117" mass="124478" checksum="EF8BE55FDFB45852" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1T7</accession>
    <name>M2T1T7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_33378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695526.1">
        <property type="nucleotide sequence ID" value="XM_007697336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1T7"/>
    <dbReference type="GeneID" id="19137149"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33378"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_1"/>
    <dbReference type="OMA" id="CELHIWP"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="102"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="347" mass="37441" checksum="CE1A902FF2FBD534" modified="2013-05-01" version="1">MSSQPPPYPYPYSQAAQLDPRITLPRPAIDSALAPIVDSVLLPEELDIKFMRGFDLSVTLDMILESHPHLTHAQHAVPGSAGHTIPLSVFMPATAQGPLPLLFFVHGGGMISGDRFSTIPSLVDLVQDVPCAIASVEYRLAPETPAPGGAEDCYNSIVWMSTHAADLGIDAARIIVCGSSGGAPLAAAACLMARDRSNPAVPIKAQMLLSPMLDDRCNSVSDRQFEYGVPWNGLTNRAAWNHALAGQRDTEHVSHYQAPSRATDLSSLPQAYIDAAECEVFRDPAIMYAMNMWRSGSSCELHVWPGGIHLFDAIDNPEVPVVGAAIAAKRAWLKRMMRDPRADKDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2T335</accession>
    <name>M2T335_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAM86 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_90842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700679.1">
        <property type="nucleotide sequence ID" value="XM_007702489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T335"/>
    <dbReference type="STRING" id="665912.M2T335"/>
    <dbReference type="GeneID" id="19141369"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90842"/>
    <dbReference type="eggNOG" id="KOG2497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038942_1_2_1"/>
    <dbReference type="OMA" id="PIRTYRI"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39938" checksum="7666EE472F600E38" modified="2013-05-01" version="1">MENPEQLAQLRVLQRQYFQLVEPQQLRWPDNATLKRPLVQAWLFGNLFDPSKVSSPPPARYQLRVLKELVGKLERSMTDPEEDEISDDIMEAMTTLLVASLPSETDAAQQKAFVTYSFPQQSTDDSDSGERAVTLLEARSVISSSGTTGLRTWEAALLLGSYLASEPGHVFINQKWVFELGAGTGMLSILCAKHLGVAGIVATDGDEAVVDAINTNLFLNGLDVDDDSSCQVRTAALKWGYPVDATTFSEDYGMEVPDVVIGADVTYDKSVISRLVSTLREFFDLNPALLVFISATIRNEQTFETFLNACERNRFSFERVEWRLVPEHVQEGPFYPTSTPIQIWRIARGQNTNNLFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2T370</accession>
    <name>M2T370_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_33758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695622.1">
        <property type="nucleotide sequence ID" value="XM_007697432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T370"/>
    <dbReference type="STRING" id="665912.M2T370"/>
    <dbReference type="GeneID" id="19137298"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33758"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="OMA" id="EQPVMRQ"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD68895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="511" mass="57091" checksum="FFE352C088C060AC" modified="2013-05-01" version="1">MPHAALTRESVASHNKPDDLWCIIDHKVYDLSEFVDAHPGGSVVLEQVAGQDATTAFYNLHRQEVLEKYSELCIGTIEGERSEVLIQKSGELSPVPYAEPLWLRPQFKSPYFNESHRALQREIRKFVDTHITPEAQQKEKDGTYISQELIDKMAANDMLAMRLGPGKHLHGKNLLGVVKGEEFDYLHDLVQAQEGVRANARGFQDGNMSGMTISLTAVLQWMPESELKTRVVNEVLSGKKKMCLAITEAFAGSDVAGIRTTATKTADGKHYIVRGTKKWITNGMFSDYFVVGCRTDKGFSVLLIERDAAVETKLIKTSYSTTAGTAFVEFNDAKVPVDHLLGEEHKGFIVIMSNFNHERFMMACAVIRQSRTVVEECLKWCNQRIVFGKKLIEQPAIRQKLAKMISHVEANQAWLESIAYQMTHMSYAQQSKLLGGPIGLLKSYATRSAHEIADEAVNIFGGIGLTQSGMGRVIEQFHRTYKFDAILGGTEEILGDLGVRQAMKNFPKSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T470</accession>
    <name>M2T470_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_166213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
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    <sequence length="338" mass="37288" checksum="2C1FD6920EA8458B" modified="2013-05-01" version="1">MNIPGYDALVYYTTQPNNYIGTTLFLSYIVAALYATFAIIYSLYSQYATIFGGPASKKDEKLDAARTARARHIKIYAFLASLSFATLSYNMLMFLITHFLEWNAKNSPSPSAITIEQLKRWMLESTLFQDFAQDLVKNAPNASWTEAAILATWFWNIYMAQKARERKYDASMVRKYTLLSQILPISFTVLLFIIQLHLSSPDISPTETSKEPAKPKSVPRRRSPIASLQIPNILLNASLLALPALRSNSIFMVLLLLTRAILLLPHSAIMSLRDADVVKCITVSGGFAVASVATMRKDLSYGGVLGSLGDGGYAIKALAWDALFGLIAYAVLGWGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5U5</accession>
    <name>M2T5U5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_190487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700194.1">
        <property type="nucleotide sequence ID" value="XM_007702004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5U5"/>
    <dbReference type="GeneID" id="19133720"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_190487"/>
    <dbReference type="eggNOG" id="ENOG502RH40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433447_0_0_1"/>
    <dbReference type="OMA" id="DMDAGNY"/>
    <dbReference type="OrthoDB" id="3798353at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="631" mass="70016" checksum="75112122081056BD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6B2</accession>
    <name>M2T6B2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_32606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694338.1">
        <property type="nucleotide sequence ID" value="XM_007696148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6B2"/>
    <dbReference type="GeneID" id="19136841"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32606"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OMA" id="GFVRMIS"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="84"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="602" mass="64134" checksum="73E046AFCF0E3BC8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6Y8</accession>
    <name>M2T6Y8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_32810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
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                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Han J."/>
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        <source>
            <dbReference type="EMBL" id="EMD64987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="264" mass="26724" checksum="E50A1BCE04744212" modified="2013-05-01" version="1">MRASALFAPLFLAATALGQAVEEGIAPDATIPDGCEATVDTPFKIGTLENPSLKKRETAQQASDGELYCTLKDGILHDQFGRTGSIVANRQFQFDGPPQAGAIYTGGFSVCKNDSLAIGGSTRWWRCMSGAFGNLYDEWIGAQCHEIRIQAIFDKSSSSSSSDASKTSSASSDASATESSVSGSVTSTANSTTSLTSGASSTFASATSSSDSESSRSSGSAGSSTSPTGSADAPPANGAAPSLLAAPFAVFGVSAVFFGAALML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9X4</accession>
    <name>M2T9X4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_35965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD66031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698440.1">
        <property type="nucleotide sequence ID" value="XM_007700250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9X4"/>
    <dbReference type="GeneID" id="19138630"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35965"/>
    <dbReference type="HOGENOM" id="CLU_2426871_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="104" mass="11595" checksum="11BD66D0AE719DCA" modified="2013-05-01" version="1">MIAAVKSGDSTRTCSASTSLFTHSMLRIDHLPSRHVDGTILVHLWWSMGVVSSRPWILRACGSWIATTATSCNSSSFIKLSCTSPCFLTLSWIMRNALFMLRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2TA95</accession>
    <name>M2TA95_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_85358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697683.1">
        <property type="nucleotide sequence ID" value="XM_007699493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TA95"/>
    <dbReference type="GeneID" id="19141055"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85358"/>
    <dbReference type="eggNOG" id="ENOG502TDF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091797_0_0_1"/>
    <dbReference type="OMA" id="KKMWPPV"/>
    <dbReference type="OrthoDB" id="3796455at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD66106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="184" mass="19906" checksum="A2CB764B4C9A6451" modified="2013-05-01" version="1">MPPKKDTAGGEANELLPGFTDKETKLIAAAYLSSTGPDKFDYDHMAALTKNTAGSLKKMWPPVKRKAIESHPSFAKFLGQSNGDATASTSEAPKLTAAPKSRKRKPADETPEEPAKSEPDSSEPDKKPTKKSAPAGKKKGRGRPKKQAKIETMDEEDSADGGDGRGEFTSKRAVQRWLQSTDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAL2</accession>
    <name>M2TAL2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_86411</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698953.1">
        <property type="nucleotide sequence ID" value="XM_007700763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAL2"/>
    <dbReference type="STRING" id="665912.M2TAL2"/>
    <dbReference type="GeneID" id="19141107"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86411"/>
    <dbReference type="eggNOG" id="ENOG502QR6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_3_0_1"/>
    <dbReference type="OMA" id="SGWGTPW"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
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    </dbReference>
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        <property type="entry name" value="Tripeptidyl peptidase A"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
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        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
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        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF39">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026590" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="20"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="217"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD65937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="612" mass="67164" checksum="FF22FF9115541525" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2TC68</accession>
    <name>M2TC68_COCSN</name>
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        <recommendedName>
            <fullName evidence="8">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_302496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699999.1"/>
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    </dbReference>
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    <dbReference type="OMA" id="HEAEYTH"/>
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    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
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        <property type="entry name" value="HTH_APSES_sf"/>
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        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD66796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="644" mass="68808" checksum="26239657E220CA09" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCJ2</accession>
    <name>M2TCJ2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_179781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="100"/>
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        <location>
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            <end position="208"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33845" checksum="E3C9634DD7C947B5" modified="2013-05-01" version="1">MAPTSSSPNLSKRSFCPDAFPNYTIQVYLGYYLVFLIIFLAIFIASFFIHKRSGGAGKSLIGFAYILTLLLAIVSLALDLTSLLRSQCQTGGLQEMRDMALASNIIGFISIWGMLFLVVYQVNISLRKQLGSAVMMFRIICLVMVGVMGLIYIAYISLSSYLWISALGMWSEERYKLLLSSHRLSLAVRVLYTLCVIVSAALATMTLSGLRRAQLAAGDLIGWVAALHIFMFIWSSLSIVLQALSLYTEGFDPHTSIALSYVLTVFQALSFVALLGIAKHTCWKQSHKPVQHVHAPVMQGHTAYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19140859"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_81878"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="OMA" id="MEIHPWY"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD67051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="275" mass="30854" checksum="404046EB2721A0AA" modified="2013-05-01" version="1">MLLDFSRTTLGTANVNGTRCIEYIQRGLTAGYRSIDTAQAYRNEEAVGQAIREHSVPRKQIHVMTKVSTGFKQNPGSLNEVKDAVEGSLTRLKIGYVDAMLIHHPGDDTVDPEAAYRRRVTWQGLETLVELGKVRNIGVSNFNIAHLRELKQYARILPVVNQIELHPWCQQRELVNHCQKEKIPLQAYLAISRNSQESDEGLKALAKKYNVSAAAILICYSVRKGFLPIVKAEDPQHLVSNLKAEKLCIEDEDLAVIDSWDMGKSGSISEYLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">COCSADRAFT_34161</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696556.1">
        <property type="nucleotide sequence ID" value="XM_007698366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDL9"/>
    <dbReference type="GeneID" id="19137490"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34161"/>
    <dbReference type="eggNOG" id="ENOG502S1AX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032494_2_1_1"/>
    <dbReference type="OMA" id="LFEWTRF"/>
    <dbReference type="OrthoDB" id="4708870at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="386" mass="44012" checksum="A5F4C43007C74A4B" modified="2013-05-01" version="1">MGGLAFADTVAESGQPIVVPRLSRELYKQLSAHYQRALETIFEKVVIPREAPGKADHGDIDYLVDGLRSPYTENNVWDLICDLFKAEAHILRGGSASYAVQHPATIGLYVQVDVELCVGHGTSDSAELFEWTRFVKSDSDLLQIIGVSHRPLGLVCNDQGLHMRVQEIEPYNKKKALLFLTRSPEEALEFYGLDIAKYRTGFTNEEDLFDWACSGRFFAREIFQSRTEKHNDRARQTKRPMYRRFVEEYIPSHPDKGACKAWTREEVLHEAIRIFGKQAGYDAMMEEHRLKTAEEELWKEIREAVPVQSNSIALILRGLRRWVAFENGHPFITTEPNLAEPLVWSKFVSPDTRDVVLAWVKDNYGQVKSLEKARASASKEAAKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2TES7</accession>
    <name>M2TES7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_292734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697315.1">
        <property type="nucleotide sequence ID" value="XM_007699125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TES7"/>
    <dbReference type="STRING" id="665912.M2TES7"/>
    <dbReference type="GeneID" id="19136023"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_292734"/>
    <dbReference type="eggNOG" id="ENOG502SR0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066899_0_0_1"/>
    <dbReference type="OMA" id="VYRLWLY"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40854" checksum="A852C117C4D8075B" modified="2013-05-01" version="1">MLFEDLATELVVQVFLSCTSVTDVTALSSTCKRFRNIYSSSQKLAILESAAEAQFGPLHDLTQLLTHNASQPAHIFRSVPFSLALLTQIVTYGRVAEKWCEIYPFKKWKHNFESRRLLTPNERYSLRRAIYRIWLYSCAFHNPAHPRELRATRLILLKRAALLHNWSTCDLAEIADIHNVIREVVQSNICPSNGTIARKFKKRHPGNEHGLLFNIHLNYPPTAPQAYNPFTTSNPLSTHFNNTNTYTSRFAATKYSLSPSHEVGAEGWGDDIPHYYVVEDYLKLDPAQILYLKENAPLKGMVENYVRSLCHEYDWFSNNGETWVQTLEFVLDERGEDVGEFMDAIAEGELGVAVAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFY6</accession>
    <name>M2TFY6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_33124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695456.1">
        <property type="nucleotide sequence ID" value="XM_007697266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFY6"/>
    <dbReference type="STRING" id="665912.M2TFY6"/>
    <dbReference type="GeneID" id="19137043"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33124"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903169_0_0_1"/>
    <dbReference type="OMA" id="YHEVIRE"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD68161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="308" mass="34625" checksum="318BD1C5E36FEA76" modified="2013-05-01" version="1">MGGSAVDLDTKDFPRVVGEYNFLVVWRLCLPSWLFEWLQYAPIFPHARFRVQSSDKLFDLGEALCKQAAQATPDTTATETNVHTLFTDPTAKYPTQSSWSSPELGAEMAGQVLAATETTSSALAFIYYELAKNQQLQKMLYRELIAHEGYEDLDTLKLLDACIKEGLRFRPPVALTGSRCIPKGGLEVLGYYLPAGTVVTTQSLSMSRQRPDLFPDFDAYNPLRWMDEDDEFSAERRKLVVPFGVGARRCPGGNMATYQMRLILVATIRAFKITLAPETTPQAMEPFEANGYRSRHDRCDLIFTPHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2TH09</accession>
    <name>M2TH09_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_273452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026042" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="90" mass="9382" checksum="6687752550F97727" modified="2013-05-01" version="1">MQFTTTSAITLIAFASSVAASPLEARHDALEDWQVTDLAVSVPMGRPGSYPWGTLKANITDPNAINLGTSSDGSQMIVPAGSKGVVSFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLU3</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_32333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694264.1">
        <property type="nucleotide sequence ID" value="XM_007696074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLU3"/>
    <dbReference type="GeneID" id="19136734"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32333"/>
    <dbReference type="eggNOG" id="ENOG502R2MX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1185381_0_0_1"/>
    <dbReference type="OMA" id="YSQHNGC"/>
    <dbReference type="OrthoDB" id="3912456at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="230" mass="25230" checksum="0F723E1E235161E3" modified="2013-05-01" version="1">MCYHNYSQHNGCGHIGESHEHPWTLCDQAIQRLNNLRGPGSPPVSPPATAPPKRTSSTRRFFSLSGQLSRSNTSASTSSRRSGASAPRTSVSSSGSYTYTVELDYSTLPDHQLAAVRCADPTRRTYVSRGMVVCKECARWIEAMRSMIQFYDKKGSVRGTAAFEKFLKWEGEGGGEREGDLTVPLDSGDDGAVYGARQAIILGHPESAMNAEGPRGLGTLEREMESRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLX3</accession>
    <name>M2TLX3_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_32365</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694272.1">
        <property type="nucleotide sequence ID" value="XM_007696082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLX3"/>
    <dbReference type="STRING" id="665912.M2TLX3"/>
    <dbReference type="GeneID" id="19136743"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32365"/>
    <dbReference type="eggNOG" id="ENOG502SP0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056959_0_0_1"/>
    <dbReference type="OMA" id="CYELAMQ"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="366" mass="38974" checksum="E0EB678677D25C6D" modified="2013-05-01" version="1">MASTPTSFDWSVGGGSSTGSHLNLDTSIPATFTADDLDLGAFSARSGSMPSIAIDECEPFPNLSSPSSPVPSLWLGTTRASSPDSMPSGPPPPPSASSLSNYTTPSSYSSGKLPTTTSPLPSGEMHIAPSWEFMAHPHLPPSQLHPPTNAPMSRPAHSRKTSTSSLSAGSTDQTMSPIPEIEDDLLPLAPAPRLPRQGIFAARRAESPGPSSSRSSYTDRSRALATTPLPSRFEAETLTNEFIRHLESLDYKAYSLSPLLFARFCEAVYPNAQPSSAVELSVSMAMARFHVFLAMAIAMKVRIRDAPEHTNALLETCYELAMQQTGSSTFWQEAGAMEAAQLLALFAALRKSGGGEEGGLRHSFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TM81</accession>
    <name>M2TM81_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_214309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695046.1">
        <property type="nucleotide sequence ID" value="XM_007696856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TM81"/>
    <dbReference type="STRING" id="665912.M2TM81"/>
    <dbReference type="GeneID" id="19134462"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_214309"/>
    <dbReference type="eggNOG" id="KOG4067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084839_1_1_1"/>
    <dbReference type="OMA" id="WWAKFER"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="216" mass="22554" checksum="A2DBB23C6DE5790E" modified="2013-05-01" version="1">MSSPVGIIISGRPVITEPSSIISPTQSAFQIPSQPSFSHIVVFLLPGVALPDGTAAAVYAQLPGTTEFKLLGAIANEKPSAIFKVNTKAGSLGSDDSMVDEGVSMDAANGSTALLALGISVEPAQQVTAAIEQNKAQAAAGPQPTGAIQGNELVLRGQRSVETKVLAQRIIKNCYDFLTSWGTGDTVPLKAFQAWWTKFEGKIERDPGFLERGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2TMX4</accession>
    <name>M2TMX4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_78219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695195.1">
        <property type="nucleotide sequence ID" value="XM_007697005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TMX4"/>
    <dbReference type="GeneID" id="19140651"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_78219"/>
    <dbReference type="HOGENOM" id="CLU_097238_1_0_1"/>
    <dbReference type="OMA" id="NNPEFPA"/>
    <dbReference type="OrthoDB" id="4093325at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD70052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19108" checksum="D0B0FE38C35FE7EA" modified="2013-05-01" version="1">MALASASQVFSIVPLSGTSPIHLGAVGTYDNGLAIGPKQNASCGVPDVNYASFFLSDEPNNLYLYTDNPPRRAFVDLSEFGNSRIRFYSGVAPTPDENFELAQFTIKDDALFLVDHSPEGVRALNFQGCPLRNGEGYSVNVNNPEFPASPSCIEFTARVSYTDKPIKCLYNDIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2TN49</accession>
    <name>M2TN49_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_217147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695240.1">
        <property type="nucleotide sequence ID" value="XM_007697050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TN49"/>
    <dbReference type="GeneID" id="19134516"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_217147"/>
    <dbReference type="HOGENOM" id="CLU_061412_0_0_1"/>
    <dbReference type="OMA" id="YNTVVFD"/>
    <dbReference type="OrthoDB" id="3693656at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD70107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="290" mass="32473" checksum="19AB4CAC0F407910" modified="2013-05-01" version="1">MSERIQPQQCDEQNREYVPSTRSIYYDGRIANALFPPSYPNNDPDTPTWKDGLREIEAFDWLRNDDNEMYNEGEASPLETILTPNPATIVEGCSEYGKTSSLPYGYALSDPTPALDHLSSETATTRVPEVFKPYKPVPSCTSPPGILEPTPIYEPTNPVHGLRPYLSAQSYSSTPVCPSTPPYQNPYTDPVVQTPQNVQAPRSLEYLQSMRYSPPLVTIRERKVPGDEVLVEMLYNTVVFDSSPSSIPTPKNPNKSQEYFNNMKIREPGNISPTVPLVPTPKKESKVQIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TN78</accession>
    <name>M2TN78_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_107483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695269.1">
        <property type="nucleotide sequence ID" value="XM_007697079.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2TN78"/>
    <dbReference type="GeneID" id="19130029"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_107483"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="OMA" id="ECKQTFE"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="7">
        <location>
            <begin position="296"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="831"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="872"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="914"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="956"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1124"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1166"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1208"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1251"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD70142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1393" mass="154562" checksum="7086FDCE96F313BF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSE1</accession>
    <name>M2QSE1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nonribosomal peptide synthetase 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular siderophore synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_358670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ND90Pr</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445723">
        <property type="protein sequence ID" value="EMD58109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706190.1">
        <property type="nucleotide sequence ID" value="XM_007708000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSE1"/>
    <dbReference type="STRING" id="665912.M2QSE1"/>
    <dbReference type="GeneID" id="19138574"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_358670"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_3_1"/>
    <dbReference type="OMA" id="WALHPAI"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="307"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD58109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="918" mass="101092" checksum="200182394B63B245" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSX1</accession>
    <name>M2QSX1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_280891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445658">
        <property type="protein sequence ID" value="EMD58274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706034.1">
        <property type="nucleotide sequence ID" value="XM_007707844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSX1"/>
    <dbReference type="STRING" id="665912.M2QSX1"/>
    <dbReference type="GeneID" id="19135808"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_280891"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_1"/>
    <dbReference type="OMA" id="RHIFEND"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="262" mass="27624" checksum="A58ABA04C7DB2A76" modified="2013-05-01" version="1">MKIANRTFLISGGVSGLGLATARALHQQGAYVSLLDLNAENGSKVVSELGSRAKFFETDVSDTQAIAAAVQGTVAWVKETGKHIGGVVAGAGVGMPGLIIDKKNEPLSLENIDFVLNINLRGTLDLIRQTLPQMTTAPSSGPDGARGVIIMIASSAAFDGQMGQVAYAASKGAVASLTLPLARDLSRYGIRAVTIAPSMFDSAMTRMMSDKVRKSLESSMEFPKRPGQPDEFARLVVECIGNDMLNGTVLRLDGAMRMPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2QTM8</accession>
    <name>M2QTM8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_103326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705635.1">
        <property type="nucleotide sequence ID" value="XM_007707445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QTM8"/>
    <dbReference type="STRING" id="665912.M2QTM8"/>
    <dbReference type="GeneID" id="19129838"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103326"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030612_1_2_1"/>
    <dbReference type="OMA" id="GSMSMCA"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD58524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="440" mass="49258" checksum="CFB9513F286E42C6" modified="2013-05-01" version="1">MEEEDLHDTYDPTSDPEEQKLIISVLDSFRSYRRHAHYNATHTRRQAFYSLPSAHWTLLSQPPFSLLATFSTVDDLIDQNANLAEAIFAAGFKSFLAPTLDSEWVASIVPEKYARDEFKVFDIVLDALIVDGRGSRAGQNDLEKARSCVNQFYREWSEQGQEERKACFDPVLSALQGEFAQRAKTADAASEQDRGDFRVLVPGVGLGRLVFDVCRAGFSVEGNEISYHMLMASALVLNETKHAHQFSIAPWALGSSNHVSRADQLRTVEIPDVHPATVLGEEQASRVPASDRMSMSMGDFCVVYGRSDYTGVFDAVTTVFFIDTAPNLIRYIEAVANCLKPGGIWVNLGPLLWHPPPPRRNHGEEDEEEASRIESDAGIGDPGSFELTNDEVIALVQHLGFNIERQETDTIQTGYITNTRSMLQSTYRPSFWLARKKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2QTX8</accession>
    <name>M2QTX8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_41704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58589.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62244.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R507"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_28637"/>
    <dbReference type="HOGENOM" id="CLU_1610610_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="165" mass="17992" checksum="F6F877E31628501E" modified="2013-05-01" version="1">MSLAPGMRDSNHCVAVYLNAASVSFSTENLIIIVLHIICVPHAEALDCGSSESTDALYPLCNGLLRNLSGCYLSVASPSTRLTSIDNWKLSSLLGHSAFVPDSIVLRPDGMSLAELHWEDKSTSTANLMPSHALEPTEEQLRRQYLRSSRLSLSGFKSHNFTTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2R5G3</accession>
    <name>M2R5G3_COCSN</name>
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        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
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    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_38356</name>
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    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701601.1">
        <property type="nucleotide sequence ID" value="XM_007703411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R5G3"/>
    <dbReference type="GeneID" id="19139235"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38356"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_3_2_1"/>
    <dbReference type="OMA" id="DILSWSM"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024120" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="82"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD62414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="431" mass="45788" checksum="F5FF809991B73249" modified="2013-05-01" version="1">MYILNAKIALLAAATASLTVAWPTAILDAAGHDPEVLKRAEEEVAKAMQARQSNSASAATSIFEPVPIFDAKAQYIDVSAGSGHEYVPPGPDDLRGPCPGLNALANHNFLPHNGYATVAQYVEATTKVVGMGPTLALLLSAVGGALSGDILSWSMGGKPSLGQAGLTGILGNGLTGSHNKYETDGSPTRGDLYQTGNNFKTVPAQFQQLIDASPGGFVTLESLTAFRSARVDAQRKSNPYYFSGPFAGVLVQPAAYTFIFRFMANHSAENPEGVLPYDVLQSWFGIQGTNGKYTAVQGGERIPNNWYRRPIAYPYDTPYFLADTLNAATLYPKFLEVGGNTGQPDSFVGIDVASLTGGIFSSANLLKGNNLACFVYQISALAKPDILLGLLTTLLDIVNNAVAALSCPQLKNFDQSVLKQFPGYNRQNVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2R9D0</accession>
    <name>M2R9D0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_90970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700606.1">
        <property type="nucleotide sequence ID" value="XM_007702416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R9D0"/>
    <dbReference type="STRING" id="665912.M2R9D0"/>
    <dbReference type="GeneID" id="19141378"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90970"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035744_1_0_1"/>
    <dbReference type="OMA" id="DAIKWKV"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD63514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="423" mass="46827" checksum="73C33DF88169FAAA" modified="2013-05-01" version="1">MKDPVEKRAKDPVQVVKQLLRTVVRMFYETEHIVIMDALCYHGALPVADMTIILDAGKNSKHVSKVAGKLREAGLCSSYTQHVMRQGANKASSREFFYIDWRHAVDSIKYKIYKIDEGIKRDAKPTTEKPEFKCLRCKSTYTTMQALDHPDDNPGPDDSGFLCARCGFRLDEIDPDAQADDIDDTPAKFNKLFGPLIETMKEIESMGSLPAMEPADIISERIELPRDRNVDPGTQVEVIETTVLRPTAVKGIDTGPEKINVQIGSSAEQNEKQRMAEKARQEKISMQNQLPSWHTQSTVIKDAAGNTTAVKQEDNGVDTPTIKIEGGDAIASNQNLDAVFAQIEAERRRKEQEEEDEDDEDEDEDEFEDVDVGTPSALPDAKRVKLESSAAPTPSAAATPAVITPAASNGGDESEEDEFEDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2RFQ8</accession>
    <name>M2RFQ8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_139691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="154" mass="17634" checksum="B63FC52EEF0DB559" modified="2013-05-01" version="1">MDPVLRKAPRGRPLEANNIDHVIRCYGGKTIAIDMEPHQMQKSKQPKDMVQYIDFLNRRNGELRLELTFYRECYQHAEKFKEKITGISQDLLQACIIGVLDGIDFGEIRDHSSAVSDAVDQYSYAQEQAFHAFIAPYKASRNPTKTTVSIDGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RKI7</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007698726.1"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_178910"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
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    </dbReference>
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        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
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        <property type="entry name" value="adh_short"/>
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    </dbReference>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="304" mass="33036" checksum="20198625E3FFEFD3" modified="2013-05-01" version="1">MENLPVDHFVKAQQFVPVVHRDVYPAIDPKQSSLSQQGKVIIITGASQGLGARSFVPSFAAAGAKAIILVARRADKLEEVAKSIATSYPNVETLSISTDIADPKSVAALYQKVKEKYGHADVLVNNAGLFKAIGPVKDVDQAAWWDEITLNTRGTFLMTQSFLKHLPSADTPAKIITLTTGAAYEVFPSLSAYGISKLTVLQLMTYVAAESPNVFAVALHPGIVDTEMTIDSFKRFALDTPELVGGVGVWLAGWQGVDRKFLEGRFVSANWDVEELVKRKEEIEKEGLLKMDLKGTLGAGQFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RKX6</accession>
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        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
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    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_179016</name>
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    <organism evidence="5 6">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697011.1">
        <property type="nucleotide sequence ID" value="XM_007698821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RKX6"/>
    <dbReference type="STRING" id="665912.M2RKX6"/>
    <dbReference type="GeneID" id="19133173"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_179016"/>
    <dbReference type="eggNOG" id="ENOG502QRHZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061316_1_0_1"/>
    <dbReference type="OMA" id="HFNLPWH"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="116"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="332" mass="36574" checksum="99FE88B903CC8FCF" modified="2013-05-01" version="1">MLRTLSLARFPAASRAQPLRRFSIKATTMAPLRAGFVPEHFCTPLEFAKRHYGLDVDLIPFPSGTGHMVTAIQAGEIDLAVGLTEGWISALGKAQAAKQDAGFKIVGTYVETPLCWAISTGAKRDELKGVQDLKGKKAGVSRIGSGSYVMSFVLADQQSWLNTSSDSPPFPVEILNTFKNLRDAVNSGAADFFMWEHFTSKRYYDNGEIKRIGEIYTPWSSWKIVAANHLLTSKSGSKPSLAPELEDMLDKVNKGVKHFEENTEEAVKFIITKLDYSEEDAREWLKTVKFSQQVKGVDKAVVEKTVGILQKAGVLGKDVNQADMIALERVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2RN06</accession>
    <name>M2RN06_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_32973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695423.1">
        <property type="nucleotide sequence ID" value="XM_007697233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RN06"/>
    <dbReference type="GeneID" id="19136984"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32973"/>
    <dbReference type="HOGENOM" id="CLU_1740375_0_0_1"/>
    <dbReference type="OMA" id="CRQDEWV"/>
    <dbReference type="OrthoDB" id="10377994at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="150" mass="17006" checksum="E014344A9A3B8060" modified="2013-05-01" version="1">MKVTVDAGMDGNDVSMMCYTHLPGNLRDSLHEKLQTDPCTYYSLLLHSTIFYATDQSVPQASDRAGILCRQDEWVLRLIATWSSFAGDTSRARRHADFGTVPRSWFLFLPTTHTMPVYRDAGRAGLCLHEIAWVPYICHTHVRLQRHGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RNK5</accession>
    <name>M2RNK5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_108466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695881.1">
        <property type="nucleotide sequence ID" value="XM_007697691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RNK5"/>
    <dbReference type="STRING" id="665912.M2RNK5"/>
    <dbReference type="GeneID" id="19130056"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_108466"/>
    <dbReference type="eggNOG" id="KOG1442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021601_0_0_1"/>
    <dbReference type="OMA" id="GMGSWAV"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
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        <location>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </evidence>
    <sequence length="361" mass="41234" checksum="962FD35D533280C7" modified="2013-05-01" version="1">MFVPRALRLKGVREKPRPNTSNPSVSNAETDRDEALVKAMQNTRTNSLTPQPEERVALKATKSGPRFTVKPVTPEYVAQLAAGIELIFTDYAHQEKERAKWLRDRYRTVDGEENYIHLTAILEHPNISSLKPEASQVLLQQALRDHPSKMLQVSNNGYHIRRKPSSYPPKYLPHNSFEVVDDDGLAFWDQRTIYVEPHIRNMCQTPAKVAQWLTEHGPLRLKWLPVQAVHTLWNSCAFVVLSGSVMHEDVWQKWREADKPENWKIMTKVEHTKRTAEYVALLEKQNPRGMRKTKVDDSELPPIARPAVLPLAVNSTQENTGNDIQQGKKKRKRRKPNKSAPNTGDADADDAADEPNTKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT24</accession>
    <name>M2RT24_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_278624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705839.1">
        <property type="nucleotide sequence ID" value="XM_007707649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT24"/>
    <dbReference type="STRING" id="665912.M2RT24"/>
    <dbReference type="GeneID" id="19135762"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_278624"/>
    <dbReference type="eggNOG" id="ENOG502SDA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006300_0_0_1"/>
    <dbReference type="OMA" id="KRAYGAP"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="699"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1086" mass="119248" checksum="7BF6EFA8DB256256" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2RTX2</accession>
    <name>M2RTX2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_342177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695192.1">
        <property type="nucleotide sequence ID" value="XM_007697002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RTX2"/>
    <dbReference type="GeneID" id="19137525"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_342177"/>
    <dbReference type="eggNOG" id="ENOG502RZI8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056771_0_0_1"/>
    <dbReference type="OMA" id="MSPHWLY"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD70049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="308" mass="33856" checksum="45F7589AB1322733" modified="2013-05-01" version="1">MTLKYTPLTDFRLPDYPDAPLTLDGAPLGIVDTESLASEITNNKNTTIPPAIGIATLLYNWHPNALAAFLDLDAWFSFTWTVSIEPGTPSGCKIEIGRIGNQITFGQLDASGENWAIMLTYNIKEPPKKGTWIPNPKESMLGPRDITSSALIPRLASTLLSRLLVQRRWETGKRIKHNLCVEYAPMDIWGDGIPMSPHWLYKALDLSTCTSCGSAGAADKALQRCGKCGTATYCSDACQKGDWKVHKGVCTMGLEDRGQAIRLVEKGGLIAWDEERMFAVEGSEEVSRNPYFEGCVGKRVRAVVSNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RVQ3</accession>
    <name>M2RVQ3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_255231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
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    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_255231"/>
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            <end position="103"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="134"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="315"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="396"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="464"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="494"/>
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    </feature>
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            <end position="515"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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        <name evidence="4" type="ORF">COCSADRAFT_202905</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
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    <dbReference type="GeneID" id="19134239"/>
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    <dbReference type="eggNOG" id="ENOG502SNIG">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="280" mass="30539" checksum="1E2FE2897D77D2C1" modified="2013-05-01" version="1">MITVLTYPSQTLTLPPNSHQFPVQHKTSDFNSAALQSAFTGYDIILNTMAGGDSDLQISIINAIVAAAVKRFVPDEFSHDNLNKQLQACLPTHAERAKVINHLKNLSDAIATGYTLNTKIINGYMGFDIEWQSATFHGTGMEMFAASSLARIGQVVARVLAHWEKTKNQYIYAAGAVISANEVLKSVEEMTGQEFAVGSYGVEECVEEGWKRIERGYPDSGLALLERSILYDGQLNASAPFRIHNANDMLGLAPESANSMVTEAYHRLKHLGKPGCACAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2S1E0</accession>
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        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="11 12">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD61063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="19133435"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_183961"/>
    <dbReference type="eggNOG" id="KOG2398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003525_0_0_1"/>
    <dbReference type="OMA" id="ETTVRWN"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106006">
        <property type="term" value="F:cytoskeletal protein-membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
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                <person name="Henrissat B."/>
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                <person name="Han J."/>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2S445</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD62133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S4Q7"/>
    <dbReference type="STRING" id="665912.M2S4Q7"/>
    <dbReference type="GeneID" id="19133401"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_183255"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_1_1_1"/>
    <dbReference type="OMA" id="KMINYRM"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD62133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="210" mass="20588" checksum="F06D52F4A458F1F4" modified="2013-05-01" version="1">MSGAANRQGKMQNLINYRMKVTLQDGRQMVGQMLAFDKHMNLVLADTEEFRRTRRKGKAAPGATQQVTETEERRAIGLTIIRGAHVISLSVDGPPPADPAARLGANSGPSTTAALAAGPGVARPAGRGLPVGLTGPAPGVGAPGPGFGGGFPGAPGGFGGPPGFPGRGGPPGGPPGFPPAGGPPGFGGPPGFGGPPGFPGRGGPPGFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6G4</accession>
    <name>M2S6G4_COCSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_223954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702028.1">
        <property type="nucleotide sequence ID" value="XM_007703838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S6G4"/>
    <dbReference type="GeneID" id="19134645"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_223954"/>
    <dbReference type="HOGENOM" id="CLU_046000_0_0_1"/>
    <dbReference type="OMA" id="QADWSIL"/>
    <dbReference type="OrthoDB" id="3737134at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="491" mass="53968" checksum="03733999D4B0DC03" modified="2013-05-01" version="1">MVLSLVRNQGVPALAYPVNDESVLWPCSLKILHSDDQFALSLGHSVSIHGVDDPQLLTLRYEGDNLIPGKMSLGNVDIALPGTSLHDIARHGKPRPRMLSLTLKAPCSVWYPHTLGKRGLGLHTGFHELLTLARATEVRILFDINWLEKSNLARLQGVIEGSRQPTGVPAIPQFTRLYHQADWSILNCIKDTEPEALPSIENAVVGAPPPIEEAVDDAPPPYARVSGKRSRNARTSLTPDSPLPKRLLQDHTYPRSSKERASPASPLSAKSTASSTATVQVDIFQDLVTSAVEKVLPDLMRAQFPTILQDLLPGILAGSSPSPSLSPTRHSSQLANTPIKHRPIPSQKPTPSTVVKSVISAYTETHLQRILADALDQASHQASEIHNSANAEFEDHLADTRLDFAALKEDHLTAFNDECNEKLVEFKERLVEEKDEVEVEVKAHADMVVLKTWDRLNRVDGEVCPQCKCVCSTRHKQSEVSQARRAISLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7X9</accession>
    <name>M2S7X9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_41671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_41671"/>
    <dbReference type="eggNOG" id="KOG0254">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
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    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_Sugar_Transporters"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="24"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="EMBL" id="EMD58550.1"/>
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    </evidence>
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        <source>
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    <sequence length="552" mass="61314" checksum="6E956E62D190BDE3" modified="2013-05-01" version="1"> </sequence>
</entry>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007707021.1"/>
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        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="349"/>
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        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="374" mass="40645" checksum="72E2764B7F83E3A6" modified="2013-05-01" version="1">MSPIAPGQLPAELVNLLALHSSFLTALSLHYAHNGISTPADLQALTASTTLVWRQRKVTYDDVRLLIGILDHGPSGANNPYYLSDYGRGKICIEIKESSPMMNGMTHMNEQGLQEMFKEGLDTLWSQWCASQKMSTRPIAVPKRGRGRPKKTDVNQATMETFLDDASISKFLSQLPLAEITTCGSLIALAPSQEKGRKRLREFKESVQQGRAQKKTRPATGKENESTTCQTQQTQPAQPKITEFAAVRKTNLLDRILAKQEAAKAGPAAPSPAELQRRAALQRTPEVLGVLSLLCASKPGSRVSFSTTTLVQALQGSIRTPISKDEAMKCVEVLASEVAPGYVSLVSMGAMSSVVINQMMRPTDIKSRLIALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2SC02</accession>
    <name>M2SC02_COCSN</name>
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        </recommendedName>
    </protein>
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        <name evidence="20" type="ORF">COCSADRAFT_141090</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699395.1">
        <property type="nucleotide sequence ID" value="XM_007701205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SC02"/>
    <dbReference type="STRING" id="665912.M2SC02"/>
    <dbReference type="GeneID" id="19131189"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_141090"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_3_2_1"/>
    <dbReference type="OMA" id="WAHKSYN"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="353"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD64838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="480" mass="54446" checksum="76DB6844C6D37D13" modified="2013-05-01" version="1">MPSHQPTAGMMAVDPDYVKQPSSMASTSEPNRNPKYDPKKPHITDTPITKSNWYKHVNWLNVTFIIGVPISGCIAAFWTPLKWQTALWAVIYYFWTGLGITAGYHRLWAHKSYNASLPLSIFLALVGGGAVEGSIRWWSRDHRAHHRYTDTNKDPYSVRKGLLYSHLGWMVMKQNPKRIGRTDITDLNEDPVVVWQHKNYIKVVIFMGLIFPSAVAGLLWNDWKGGFIYAGILRIFFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWSIWLWSKLGLASNLKQFRANEIEKGRVQQLQKKIDQKRAKLDWGVPLEQLPVIEWDDYVEQAKNGRGLIAVAGVVHDVTDFINEHPGGKTLIKSGIGKDATAMFNGGVYFHSNAAHNLLSTMRVGVIRGGCEVEIWKRAQKENKEVNIVKDEQGNPIIRAGNQVTKVAQPMLSASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCD6</accession>
    <name>M2SCD6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_99895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704340.1">
        <property type="nucleotide sequence ID" value="XM_007706150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCD6"/>
    <dbReference type="STRING" id="665912.M2SCD6"/>
    <dbReference type="GeneID" id="19141880"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99895"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029282_1_2_1"/>
    <dbReference type="OMA" id="WQRKRIV"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="334" mass="37210" checksum="86FD74A33C3B6932" modified="2013-05-01" version="1">MLSSCSLRHPAYQLLWRNVLVSRASPCRPLARSFHASTPRQDPIIDAILYLPHEMISLIHTAVPWHAAIPLSAFLARGLLVTTAGTRARALMARYIGLHPLRQALAFQTRDEILKRGNFRSPQQALVTVKKEVKDVTSALDKRWNVTLSGQISWTLAQIPIFFAMAETIRQKCGAQDGLLGMTMSIFRGESTRMTTETGQVVARVTPTDWFEPTLATEGMLWFPDLLLPDPTGALPFIASGIMFANIYTSKNTVESGAKWPNVLRRTLLFVSLLIGPLCQNLPAALMLYWSSSTASVMLWNAWLDRKYPAPRGYTACKRPLLLPPAPISKLCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDP2</accession>
    <name>M2SDP2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_85810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698575.1">
        <property type="nucleotide sequence ID" value="XM_007700385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SDP2"/>
    <dbReference type="STRING" id="665912.M2SDP2"/>
    <dbReference type="GeneID" id="19141076"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85810"/>
    <dbReference type="HOGENOM" id="CLU_127753_1_0_1"/>
    <dbReference type="OMA" id="PQNVDAD"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="103" mass="10668" checksum="F701D037076F0DE6" modified="2013-05-01" version="1">MAEPQPSTIHEGASTPALDGTPSTPSNGAKKEVDGKALDKAMKGLSVKDKAEEEKKKNIKIEAGDVAVLVSELEITKAKATELLRANEGDAVKALVAFVTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEU2</accession>
    <name>M2SEU2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_237950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703336.1">
        <property type="nucleotide sequence ID" value="XM_007705146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SEU2"/>
    <dbReference type="GeneID" id="19134923"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_237950"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_49_0_1"/>
    <dbReference type="OMA" id="YGWIDDA"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="29"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="319" mass="35964" checksum="53D19218B8B4B178" modified="2013-05-01" version="1">MQQENESLKLPDGRKLSYAIYGSPVPQRTIIYLHGYPSSRYEGKLWHSSCATHNIRLIAPDRPGNGLSTFQHNRRILDFPADILALTEHLKIHQFYVLGVAEGAPYALACIKEIPKERLLSASIVGGLYPVKLGTSGMILPSRIVLWIAPWMTSFTAALFDNKMGRPSRNEDPRVFEDALSREVENWHPGDQKAIRCANVWPTFVAMTKESFHQGSEGVGWEAKLNGSEWGFELAHVHVGEGEVPLTLWHGKDDRNSPIGMVERAKELLPGCVLRLKEGEGHFGFISRDADEILEDLVRREGKEEKEEFMMVSVTQVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFJ5</accession>
    <name>M2SFJ5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_163576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703505.1">
        <property type="nucleotide sequence ID" value="XM_007705315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFJ5"/>
    <dbReference type="STRING" id="665912.M2SFJ5"/>
    <dbReference type="GeneID" id="19132258"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163576"/>
    <dbReference type="eggNOG" id="ENOG502S6EF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147114_2_2_1"/>
    <dbReference type="OMA" id="KYKLRIH"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="10">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD61205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="111" mass="12459" checksum="E423D6F07C3B73B8" modified="2013-05-01" version="1">MALAAYRNLLRSARIAFQGDTHTFVAARAEVRKNFESNRNLRIGSEELQKSLVHAEEVSKFLRENVVQGQAEDPDGKYKLRIHEHTERGDNEDIKKGKGKTTLGGTKCCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFW7</accession>
    <name>M2SFW7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_34707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697483.1">
        <property type="nucleotide sequence ID" value="XM_007699293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFW7"/>
    <dbReference type="STRING" id="665912.M2SFW7"/>
    <dbReference type="GeneID" id="19137818"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34707"/>
    <dbReference type="eggNOG" id="ENOG502S0R5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015147_1_0_1"/>
    <dbReference type="OMA" id="KYSWMTG"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="310"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD66123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="622" mass="66654" checksum="C204DD54FDDF3D70" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SG03</accession>
    <name>M2SG03_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_45542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702656.1">
        <property type="nucleotide sequence ID" value="XM_007704466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SG03"/>
    <dbReference type="STRING" id="665912.M2SG03"/>
    <dbReference type="GeneID" id="19140204"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_45542"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_45_8_1"/>
    <dbReference type="OMA" id="VNGMIHA"/>
    <dbReference type="OrthoDB" id="3664645at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="96" mass="10337" checksum="5107434498C0BF7D" modified="2013-05-01" version="1" fragment="single">MTALHWAAVNGMIHAVDFLIDKGLDVDRRCKRGKTALVLAAENGHTTMVELLIEKGADVNALSTEPRKSTPAVWAAILGHDKVLKTLIQHGADLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIE0</accession>
    <name>M2SIE0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_147569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702430.1">
        <property type="nucleotide sequence ID" value="XM_007704240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SIE0"/>
    <dbReference type="STRING" id="665912.M2SIE0"/>
    <dbReference type="GeneID" id="19131419"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_147569"/>
    <dbReference type="eggNOG" id="ENOG502SNCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102622_1_1_1"/>
    <dbReference type="OMA" id="RSWINEC"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="80"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="197" mass="22137" checksum="5344708A420A8AA7" modified="2013-05-01" version="1" fragment="single">MADVSIVYTEFSISHTLPSDTREALPFLVEQYHECCAHHAQCSTPESAELDQYPSRLLDIGHEGSKIILRNTKMFSNQQYVCLSHCWGESKPYALNSTTQQDLEGGVDAENLPKTFQDAIHVTRRLGIRYLWIDSLCIIQDSEPDWEAESSRMGQVYARAACTIAATASSGSDGGLFFERHPQQSLPRLLDIHFDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKJ9</accession>
    <name>M2SKJ9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_291961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697284.1">
        <property type="nucleotide sequence ID" value="XM_007699094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKJ9"/>
    <dbReference type="STRING" id="665912.M2SKJ9"/>
    <dbReference type="GeneID" id="19136017"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_291961"/>
    <dbReference type="eggNOG" id="ENOG502R82D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041583_1_0_1"/>
    <dbReference type="OMA" id="FHRTSKW"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD67688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="287" mass="32462" checksum="6DBB3795F89C43BB" modified="2013-05-01" version="1">MAVKKRQKTLSHGRPPISKPKERMTSERSRTIIRTHHRLQKEHAAALKKGDLSSAEEIARAIEKNGGIKTYQAASKQGQAKDRGGDSSKILVEWLQKSHVLAVKERSHIIHKLRCLEIGALSTKNEISKYSSVIDMTRIDLNSQGPGIEKQDFMQRPLPTADSERFDIISLSLVLNYVPDATGRGEMLKRITKFMRRSTVKADDSLLALPALFFVLPLPCVDNSRYLDEELLLQIMGRLGFSMTFSKKTSKLCYYMFVLTREPTKATTEKKKIRDGPGMNNFCIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLX6</accession>
    <name>M2SLX6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_339910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701488.1">
        <property type="nucleotide sequence ID" value="XM_007703298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLX6"/>
    <dbReference type="GeneID" id="19137398"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_339910"/>
    <dbReference type="HOGENOM" id="CLU_2527306_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="84" mass="9233" checksum="CAC48E34DDF3118C" modified="2013-05-01" version="1">MKHEIITISAKKQADGTDHTCVGHCVSRYGAIFAQYVIALVVYLRAPPVHKRLPSNSKDVAESLKIVTTKSSTYHPITKTIPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMI9</accession>
    <name>M2SMI9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_272231</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696003.1">
        <property type="nucleotide sequence ID" value="XM_007697813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMI9"/>
    <dbReference type="STRING" id="665912.M2SMI9"/>
    <dbReference type="GeneID" id="19135637"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_272231"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="11"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="196"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD68383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="398" mass="42466" checksum="F432A84EC8C622FE" modified="2013-05-01" version="1">MSDIHRASTTAPVNIAVIKYWGKRDPKLNLPTNSSLSVTLAQSDLRTHTTASCSSGYPKEDTLLLNGQSQDVSGARTQACFRELRALRKELEAKDSSLPKLADLPLRIVSENNFPTAAGLASSAAGFAALVRAIANLYELPASPTELSRIARQGSGSACRSLFGGYVGWEQGSAADGSDSVAFQVAPASHWPNMRAVVLVVSAAKKGVSSTTGMQTTVATSSLFQSRASETVPRRMKEMQDAIQNKDFEAFGKVTMMDSNSFHATCLDTFPPIFYLNDVSRAAIKIVESINAAAGKIIAAYTFDAGPNAVVYYLEENEKEVAGLFKTILNEKDGWQGQRGQAVQANAEALEKVKSEAGPAIALLEEGVSRVILTGVGEGPVRTEESLIDEKGEPVKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMU9</accession>
    <name>M2SMU9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_134300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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            <begin position="36"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68498.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44917" checksum="D2A8BCBF226751BC" modified="2013-05-01" version="1">MLDQLRSYYSFLKPQSGVYQYMPFNKAPTTRSRTRIALITGACIIAALSVSALFVHPVEKARQYGIFQSTDTSGHGSIPSIVHYVQIKKDEKSVLKFPFSSFLNICAAVLYIKPERIYIHTDFSPSEISEASEKGDRWTKSVINTFADLVIWNPVHAPTFAGTNENQHIDAIQHKSDFLRWEALEKTGGIYMDWDVFPLRPLTPLLTTGFAFIGGRHYGGAGEQSGINGTINNGVFMTKPNSTMARIVVREQHAGFNGKWAANLQSMTNVAERLVPIPYEVLILDRTAFAPTHWFQDSTDPLFKPNEGKPASPVPEKTNSTDAMEIYEVAIKNRRRRAEWEMDFSSTYMLHAFALNRYYKYVNPKTILSRTSNFGIATYDTVRHMVDMGYVGEHDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN44</accession>
    <name>M2SN44_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_196484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696143.1">
        <property type="nucleotide sequence ID" value="XM_007697953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN44"/>
    <dbReference type="STRING" id="665912.M2SN44"/>
    <dbReference type="GeneID" id="19133986"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_196484"/>
    <dbReference type="eggNOG" id="KOG1914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007630_1_1_1"/>
    <dbReference type="OMA" id="VQLWSVY"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="223"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="870"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117464" checksum="FD9CF4D2D240DF34" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN49</accession>
    <name>M2SN49_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_351407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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            <end position="49"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="306" mass="33132" checksum="9AD3A483977E4C09" modified="2013-05-01" version="1">MAVPGTPGQTLRPPEVTHTRPEDPNTPSLANLRTTKRHRQAEAAPIPISFGDSANKRQLVTGAVTEKITAAQAAAKTRHSIITAIANAIDHCLENYTSAAERLVAQELQQRVVYALTNSIHHPSTTTPQPASDAGPKPTRTYADVAELPNSHPMQKRGAAITKTAATHRNGVTLNKPPNKPIPDSRILFQLSTAQRVKDPSPFVMRKALCAKIDNLILQDIPRLTTTKTGWALTPANDAIKSRLLQLDNVEVMLETLGAVGFQLPEKWINYAVQRVEAALIGLHIGGDAAVLISEENVAEEVYSQT</sequence>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">COCSADRAFT_176510</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNI8"/>
    <dbReference type="GeneID" id="19133040"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_176510"/>
    <dbReference type="HOGENOM" id="CLU_1864960_0_0_1"/>
    <dbReference type="OrthoDB" id="10463112at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025629" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="137" mass="15012" checksum="B26C240282855B1D" modified="2013-05-01" version="1">MKTPLIVLASGLLTAPPLGCQNVTAYNCACNPFTFNGCFKDPKKKVLLADHLAFLERDRDNRHENCRGRWVRLKHEAVKMIDGTGFGVCSGQARSITSTWRESTSADVLPGFAVTIGSSQSQGPVYYIYAPLLGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP56</accession>
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    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_263653</name>
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    <organism evidence="6 7">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
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        </cofactor>
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    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
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        <property type="protein sequence ID" value="EMD58532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007707452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP56"/>
    <dbReference type="GeneID" id="19135490"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_263653"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="WYSNRPP"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD58532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="60158" checksum="B87702105555117B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPC3</accession>
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        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_130386</name>
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    <organism evidence="7 8">
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        <name type="common">Common root rot and spot blotch fungus</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694499.1">
        <property type="nucleotide sequence ID" value="XM_007696309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPC3"/>
    <dbReference type="STRING" id="665912.M2SPC3"/>
    <dbReference type="GeneID" id="19130785"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_130386"/>
    <dbReference type="eggNOG" id="KOG2857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063513_2_1_1"/>
    <dbReference type="OMA" id="GVCATEP"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="199" mass="22412" checksum="C7ADAB083335F4B8" modified="2013-05-01" version="1">MATVLCGVCETEPKKYKCPTCALPYCSLTCFKTHKVTHPEDAASSTSKLAKPTIPQPPPPAPIPRYLKSRTDFSTLATSPKYQALIKANPILLSTFQRVYAKTIQPDPEDERRRRMLERNMSRGRGSRGRGRGRGRGGRNWEDREERWTPKKGDKDAMAVLKAIRNGEDNQEEKEAMAQFVELVEELFGKKDKTTGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQP7</accession>
    <name>M2SQP7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_106245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694859.1">
        <property type="nucleotide sequence ID" value="XM_007696669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQP7"/>
    <dbReference type="STRING" id="665912.M2SQP7"/>
    <dbReference type="GeneID" id="19129990"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_106245"/>
    <dbReference type="eggNOG" id="KOG2110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_5_2_1"/>
    <dbReference type="OMA" id="NIAILEM"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46540" checksum="914002ACDEE9BFDF" modified="2013-05-01" version="1">MNFVTFNQDHSHLGVGTTNGYRIYTTDPFNKQSESREGDVSSLEMLFSTSLVALTLSPRVLRIQNTKRHSTICEMTFRTAILAMRMNRKRLVVVLESELYIYDISNMQMLKTEKTSPNPNAICALSASSENNYLVFPLPTKAAPATFQPPSHAPPKTDHIAPTSGEVLIYDATKMEAVNVIEAHNSPLSCIALNSDGSLLATASEKGTIIRVFSIPDAQKLYQFRRGSIPARIYSMSFNSASTLLSVSSATETVHIFRLGAPNSRSNSVSSGPTRPGGSAHQRNSSRASEEASDEFGASTADMAPPERKAINPTFGSLIRRTSQTVGKSFAATVGGYLPNAVAEIWEPSRDFAWVKIPRSPNSSSSGPVRNVVALNNNGPQIMVVTSEGNYYVFNVDLEKGGEGTLYKQYSLLEPNELAASNSQDLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQS0</accession>
    <name>M2SQS0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_30912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704827.1">
        <property type="nucleotide sequence ID" value="XM_007706637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQS0"/>
    <dbReference type="STRING" id="665912.M2SQS0"/>
    <dbReference type="GeneID" id="19136340"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_30912"/>
    <dbReference type="eggNOG" id="KOG2299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_0_1"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="58"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD59466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="343" mass="38175" checksum="05CE1F10027521C9" modified="2013-05-01" version="1">MAEAQDDVHMDTQDMEDETPPSDVFMAPSISKPHLLGGRSYSHFSPIPKQIADDMAREVVLGVDEAGRGPVLGPMVYALFYLPIELHRSLLAEIHHFDDSKVLKANVRSDLMRTLCTQGTDLYEAGGWATRLLSAQDISAHMLQPSVYNLNAQAMDATIDLIKEVLAKGVNVKEIYIDTIGKPEIYQKKLERIWPTISITVAKKADSLYPVVSAASVCAKVTRDAALDVCYEPYHSRTDPEAEDGAQVQAAWGSGYPSDARTSAWMKQNMDPLFGWGNETRFSWGTAKEMLEGKKADVSIDWPAEDDGNDMRMTDFFNGKNEAIGDELVDWFGKRVTEEMEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRT0</accession>
    <name>M2SRT0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_175375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704557.1">
        <property type="nucleotide sequence ID" value="XM_007706367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRT0"/>
    <dbReference type="STRING" id="665912.M2SRT0"/>
    <dbReference type="GeneID" id="19132962"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175375"/>
    <dbReference type="eggNOG" id="ENOG502RYCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022622_0_0_1"/>
    <dbReference type="OMA" id="PEWYTSI"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="348"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="521" mass="58353" checksum="CEF1C9F7D324240A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRY9</accession>
    <name>M2SRY9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase acuF-like C2H2 type zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_25997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="Horwitz B.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703269.1">
        <property type="nucleotide sequence ID" value="XM_007705079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUZ7"/>
    <dbReference type="GeneID" id="19134900"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_237074"/>
    <dbReference type="HOGENOM" id="CLU_1461176_0_0_1"/>
    <dbReference type="OMA" id="CKPPLHQ"/>
    <dbReference type="OrthoDB" id="3695639at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="177" mass="18217" checksum="2FC9DDC1CFDA4C18" modified="2013-05-01" version="1">MSCLSSIRSNFGSVFQSKKKENPTLAEKSANTSHVSSRPSVSTSTQTSSPSYKPPLYQVPSAIVTATEKGMISASLCSVSQPPSASTSLTSTSTQTISAAAPSPFHSLPLASPSPLSLSSSSALSPFCPSPLLPMSKAEGNARESTSSTTTLTRGEEACVSGHSSQRASVRFKGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVT1</accession>
    <name>M2SVT1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transferrin receptor-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_183877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703313.1">
        <property type="nucleotide sequence ID" value="XM_007705123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVT1"/>
    <dbReference type="STRING" id="665912.M2SVT1"/>
    <dbReference type="GeneID" id="19133430"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_183877"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005688_1_0_1"/>
    <dbReference type="OMA" id="YPRKDGR"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="317"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="506"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="766"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="100158" checksum="D536A9C22A048D0E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVU7</accession>
    <name>M2SVU7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_237825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703326.1">
        <property type="nucleotide sequence ID" value="XM_007705136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVU7"/>
    <dbReference type="GeneID" id="19134918"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_237825"/>
    <dbReference type="HOGENOM" id="CLU_2037632_0_0_1"/>
    <dbReference type="OrthoDB" id="10314634at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="124" mass="14039" checksum="FE28651799146367" modified="2013-05-01" version="1">MHPLGQALVFPLLTTVLTWQWLGVIFSSSILIAVIRRPMTRDPGTPLHVCHQFIHKTEIVDKTMRVSSGRIFVRRPGHGCGRYSQGAMMLACGWHHTHDLGDDYVQCIACVDIECVHRHEVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWJ1</accession>
    <name>M2SWJ1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_39890</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703130.1">
        <property type="nucleotide sequence ID" value="XM_007704940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWJ1"/>
    <dbReference type="STRING" id="665912.M2SWJ1"/>
    <dbReference type="GeneID" id="19139590"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39890"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039068_5_3_1"/>
    <dbReference type="OMA" id="AFNKAMH"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 12 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="15">
        <location>
            <begin position="81"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD61207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="379" mass="42662" checksum="61E9D3C68E17AA7C" modified="2013-05-01" version="1">MSSVALEKEDHTRDAEFNKAMHGQTAKSRGGMTAILGKDKAAQQAAVDEYFKHWDNKAAKDETEETRKERRDEYATLTRHYYNLATDLYEYGWGQSFHFCRYAYGESFYQAIARHEHYLAHKMNLQDNMRVLDVGCGVGGPAREIVKFAGVNVTGLNNNDYQIERATTYAEKEGLSHKLNFVKGDFMQMSFPDNSFDAVYAIEATVHAPSLEGIYSEIFRVLKPGGVFGVYEWLMTDKYDNDNPHHREIRLGIEIGDGISNMEKVEVALAAMKAAGFVMEHHEDLADRDDPYPWYWPLSGQLKYISTLGDIPTILRMTKVGRGLVHRFVGCLETIGLAPKGTQKTADSLALAADCLVAGGREKLFTPMYLMVGRKPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWU4</accession>
    <name>M2SWU4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear architecture-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_39174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702586.1">
        <property type="nucleotide sequence ID" value="XM_007704396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWU4"/>
    <dbReference type="STRING" id="665912.M2SWU4"/>
    <dbReference type="GeneID" id="19139434"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39174"/>
    <dbReference type="eggNOG" id="KOG2439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_0_1_1"/>
    <dbReference type="OMA" id="GYLHHVL"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="7">
        <location>
            <begin position="133"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD61441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="621" mass="66176" checksum="8B3CEFF40DF59EBA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXJ1</accession>
    <name>M2SXJ1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_232534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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            <begin position="38"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="262" mass="28047" checksum="188C03E1BBA900E5" modified="2013-05-01" version="1">MHFYSTLSYLGLFASSVTARALETPPEIVPRPPFFALAGDSTTAPQSENGGGWGAGFINTTLHAGAAAKNFGHNGATTVSFREGGDWANVLAAAKAASKDFDVYVTCQFGHNDQKPAKNISIEQYSANLARFVHDVLDIQAWPVLVTPLSRRKFDSDGHVKEDLADVTAATLKVASQTGAQVIDLNAASTKYLNAIGPDKAHTYNLAPSDNTHLNNGGSIVFGNLVALLMNQELIQLSTKYLSPINDIADKLEKGEYVFAYV</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
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    <proteinExistence type="predicted"/>
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            <end position="32"/>
        </location>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
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            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="160" mass="18708" checksum="2BF330D1AA7B50AF" modified="2013-05-01" version="1">MDEDLIAFGIVMLLFLSFPFLTVLSITGCIAYSRTKVWDKARNQRAVSLESSETNRLVDDGDNNDDSDFYDTEDEEEHKQRQAEDEADKHITFGQKFRKEFRKVWTGKGKNDILKQKEREERRKLAKAVARELDRRERRMARRAATKVQSSEDLPAYTKA</sequence>
</entry>
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    <accession>M2SYV8</accession>
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        <name evidence="3" type="ORF">COCSADRAFT_228193</name>
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="324" mass="34877" checksum="47B2A08C121E36C4" modified="2013-05-01" version="1">MKILITGANGFVGQILAHHLLTTNTATHLILADLHEPPNPSPSSSSSENVTCTAADLTSPAACTALISQNPDAVYILHGIMSSGSEANLDLGLAVNFESVRTLLDTIRTLRPGIKVVFTSSCAVYGRAAVENVATEMDVVPMPESSYGTQKLMIEFLINDYSRRGLIDGRAVRLPTVFVRAGAPTAAASSFVSGIVREPVKGIEAELPVDPKIGIWLTSPRTLAANLVHAVKVPKEKFGHFRQVLLPGYTATSGEILDALEKVAGRETRALVKEKRDEGTERIVLSWPAKYDTTRAKELGFSEDVGLEQTIRDFIEGEKLKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0J3</accession>
    <name>M2T0J3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_268398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695771.1">
        <property type="nucleotide sequence ID" value="XM_007697581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0J3"/>
    <dbReference type="GeneID" id="19135566"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_268398"/>
    <dbReference type="eggNOG" id="ENOG502RYRX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_1_2_1"/>
    <dbReference type="OMA" id="SWWATGF"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD68065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="565" mass="62849" checksum="A0F4440081934191" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0L9</accession>
    <name>M2T0L9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Cytochrome P450</fullName>
                <ecNumber evidence="14">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="14">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_343176</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="14"/>
    <dbReference type="EC" id="1.6.2.4" evidence="14"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702044.1">
        <property type="nucleotide sequence ID" value="XM_007703854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0L9"/>
    <dbReference type="STRING" id="665912.M2T0L9"/>
    <dbReference type="GeneID" id="19137587"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_343176"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_7_0_1"/>
    <dbReference type="OMA" id="ASYNGEP"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
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        <location>
            <begin position="498"/>
            <end position="640"/>
        </location>
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        <location>
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            <end position="938"/>
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        <location>
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        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="403"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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    <sequence length="1112" mass="124018" checksum="36183A0DBDA34C44" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0N2</accession>
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            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="402" mass="41152" checksum="5D2FC347A58D12E0" modified="2013-05-01" version="1">MMYSGMTLTTTPLTLTMCEMGLPTGSPGGSVNTATVSRLTGAPPLLDATDAPTDSASGLISSTLTLSVAVSSSIVPIASDGTYPGADGISSVGQSIVGPSVSDISDTTQRVSDAVSSILPTGSFSNTGGPSTPVATAGTSNISGVSSVAGLSPGGNTPTQIGLRSETTFPASTQTSTSAGLYKPTGVLLGMDSNPRNGTISLSPLSIDALKLALFLKNLGVWVFNESRIVELSSLSASLVADIAVLDTLRTLLIQSGNMDVPSCKYDLLKNMTELSFLMVTLKSIDLGVFMSMAEAADRLVAILLSSIASVDAKYIALLGDHTHYNASVQSFDTPATPAWAYNIALRYSQPGSCSVQLPLPILPKLTINNSTSAHVQPGTKVNVEWGAAAILSGTAFAVLRP</sequence>
</entry>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0W7"/>
    <dbReference type="STRING" id="665912.M2T0W7"/>
    <dbReference type="GeneID" id="19139075"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37754"/>
    <dbReference type="eggNOG" id="KOG3655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013085_2_0_1"/>
    <dbReference type="OMA" id="FKEPRGA"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11962">
        <property type="entry name" value="SH3_Abp1_fungi_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11961">
        <property type="entry name" value="SH3_Abp1_fungi_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000242">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000273">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000045">
        <property type="entry name" value="Actin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035719">
        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035718">
        <property type="entry name" value="Abp1_fungi_SH3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="677"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="769"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="741"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="752"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="85686" checksum="4D03E36CD397EA11" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1Q0</accession>
    <name>M2T1Q0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_167681</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696046.1">
        <property type="nucleotide sequence ID" value="XM_007697856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1Q0"/>
    <dbReference type="STRING" id="665912.M2T1Q0"/>
    <dbReference type="GeneID" id="19132531"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167681"/>
    <dbReference type="eggNOG" id="ENOG502RNK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033658_0_0_1"/>
    <dbReference type="OMA" id="DYTPHFL"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="311" mass="34235" checksum="ACB20BA29B2C6A18" modified="2013-05-01" version="1">MNVQYQAFTPPHLLNNNNRRSPTRNIMPSSTAMTGRKRKADDEGSAGDDDRMSASPSTSPAILPRPAPRGMKRMRTNVSGRQLPLPRLLETLSADEMRNLLQSICQRHPDIGNEVVTTAPRPSIQSAMEVLSKYEAAFQGAFPFGNRASSDYAYNRVRQQLDDLLDSLKDFTPHFLPPNEQQPATSLAFLDGATEILHRLPNWDTYQHNRHKQEAYEEMAKAWAIVIREAAKRAGGIQLQYGGWDQKIAKHNEVSGGKMQEAVSELRGGLGWMGAETGNATTAGPTDAMSIRQQLLSGNYGSGSSASIGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3E0</accession>
    <name>M2T3E0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_76162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694425.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3E0"/>
    <dbReference type="GeneID" id="19140548"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_76162"/>
    <dbReference type="eggNOG" id="ENOG502SI8G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_25_2_1"/>
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    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF57">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
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        <location>
            <begin position="114"/>
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        <location>
            <begin position="145"/>
            <end position="170"/>
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    </feature>
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        <location>
            <begin position="4"/>
            <end position="176"/>
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        <location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="244" mass="27235" checksum="FE778D44DD63E6E2" modified="2013-05-01" version="1" fragment="single">ISFSILWNATVCFSKLSALLMYPALIPTSSMLKWACVLGTLIITWNMADVIAALLICQPLAKNWDFRLPGTCGGQPAFCFSMRLVNLLTDAVIIVLLMPYLYNLRLTWRKKLAAMALLSVGTGTWAITIYRQILLPSLDFADMTYNGVLATILSGLEPAVAIALACIPLMRILFRKSRRTTHSSYQYGSNRQTDLFPKKRSETHGLNLTATFSKLVDKNDASSQVELQSIKPSHIFRVSPVYEH</sequence>
</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10659" checksum="192F853947B637C1" modified="2013-05-01" version="1">MALRNLFKNDLVLVSTNLAVVAGVATLLGSRVEKKLDRMEEEQEARLDEIEGTIRGHIGLIEDSLDRIEGKPNAGKQDKLYNQRTRDAKRGEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4V2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_160512</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="420" mass="48073" checksum="8D45557571A0A109" modified="2013-05-01" version="1">MARNARQKAACNLRRGSRPVFQFTKLPAELQLLVICRCDLISIGRLLSVIWYVRSLCIQYPDIVIQGSLSEIPQPVAGLLHVATASHNISDDDFDSDKPLDLLEQANLDQWPAICSRFLRSGDNVLDYMRGLVDIYVEVDVAADIVAQGMNAAMQIYIDPHVAVTPVVLSVAEHTRLVSALLIVKIYYQLRSEFVPNGHTSVKDFATAFMQTLAPWQMAQGSSVEGFLDSCQKSPGGLYDEIIDKRYTCCECLLQKSSYLRNYSRAAAMDMDRGHVFGRDTSFLRYSHAVAEQHRRIDRRESWAGHVGYAQHPAIQLRNYGWIMYKTISPSDMMRRQLVWRVGMLFWDQSRLAGWGMVDASDVVTLGTRTAWRLGYMRRWYPYSLQRDRISDTTSQQIVEWTRNHEQINFEEFLARQLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2T530</accession>
    <name>M2T530_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Organic hydroperoxide resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_190466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700177.1">
        <property type="nucleotide sequence ID" value="XM_007701987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T530"/>
    <dbReference type="GeneID" id="19133717"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_190466"/>
    <dbReference type="eggNOG" id="ENOG502S77G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106355_2_1_1"/>
    <dbReference type="OMA" id="SACFSNA"/>
    <dbReference type="OrthoDB" id="60422at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797:SF2">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19171" checksum="63E486224192DF1D" modified="2013-05-01" version="1">MASRTFTPMLRQALRVSQRNIVAAPCRRFLNTETAPNLYSARAKVVGARTGHVDGENLKVELTMAKVLGGAGDKGKTNPEELFAAGYGACFQSAMNASAASLGIKMPTTPEDSIVESTVELVGSMKDLDLGLRVNLLVKVRGLSEQELEKVVNKAREVCPYSRATQGNVHTTIKCETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5H4</accession>
    <name>M2T5H4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_325851</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700260.1">
        <property type="nucleotide sequence ID" value="XM_007702070.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2T5H4"/>
    <dbReference type="GeneID" id="19136833"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_325851"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_4_1"/>
    <dbReference type="OMA" id="WVMKPIN"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000048">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="433"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="809"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1268"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1051"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1417"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1113"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1190"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1453"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1485"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1500"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD64491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1509" mass="166159" checksum="FFB8279EFD31898A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6F2</accession>
    <name>M2T6F2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_143178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700293.1">
        <property type="nucleotide sequence ID" value="XM_007702103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6F2"/>
    <dbReference type="GeneID" id="19131275"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_143178"/>
    <dbReference type="eggNOG" id="ENOG502SQH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_12_4_1"/>
    <dbReference type="OMA" id="KHQWNVT"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="37"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="265" mass="29506" checksum="663CBF318956BD33" modified="2013-05-01" version="1" fragment="single">MPPTGEMPLNPNAPTIWPWGLPIIITCFALAGIAMMIRIFTRAYLTRLFTFDDIVMTAAALTYFAFVSVTLDSISMGFGKHQWNVTVGEAMRALRRAYWVQIVYCIAMYTTKLGVLLQIKSTFNSKSRDFMFWSSWACIASFSCVYTASLFTWIFPCNPIKKKWEPFIPGTCLPTHAGPSLLSGIINLVTDVALLFLPIYAVSRLQMSIKKKFAVSGIFGAALLACISSAVRLHYTILHLDSKDNTYWLAVVAVCAIIEISALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7B5</accession>
    <name>M2T7B5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_181056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699600.1">
        <property type="nucleotide sequence ID" value="XM_007701410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7B5"/>
    <dbReference type="GeneID" id="19133280"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_181056"/>
    <dbReference type="HOGENOM" id="CLU_1769070_0_0_1"/>
    <dbReference type="OMA" id="DDTYKWI"/>
    <dbReference type="OrthoDB" id="3668416at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026160" evidence="1">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="131" mass="14637" checksum="626ADFDFB6BF210C" modified="2013-05-01" version="1">MRFLQIIPAVFAASTLAAKFEGFVDISCQRYSGDYRLITAADQQKIVVDKWASTVTAQETSRAFSPKGICPSNADDTYKWIEMPQWNDVETRFGRTAGGAIAVVYFNETDTYHACRYLASVQPNGYKGQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7I8</accession>
    <name>M2T7I8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_190140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699654.1">
        <property type="nucleotide sequence ID" value="XM_007701464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7I8"/>
    <dbReference type="GeneID" id="19133710"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_190140"/>
    <dbReference type="eggNOG" id="ENOG502SP10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_1_0_1"/>
    <dbReference type="OMA" id="HCLRIVR"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="270" mass="29968" checksum="57ED4BFA0FF6AB6E" modified="2013-05-01" version="1">MFARYKPLSSGDSASEHSPDLDSTHRRLYRVIALTVLTIANVCVLGLSIAIWRTTPTTSLATPNIPDAQPSELARVESLPIEFIPFYWNTPWGSPNASEADRLWDNINTAHGHIAVAHEFAAENHWPSSLDIPGKPGKGLYLLQAYHQLHCLQTSLSVLLQRIVRAAYLTLKRQELPIFPSDHVLHCFDALRQHIMCHADNTPLYGHGHGTAGDGQLHQCRDWNALRDYATKNTACFRDGKPGMSFEDRFGVCDDGTDGLEEHAPVLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2T861</accession>
    <name>M2T861_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_159090</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698584.1">
        <property type="nucleotide sequence ID" value="XM_007700394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T861"/>
    <dbReference type="STRING" id="665912.M2T861"/>
    <dbReference type="GeneID" id="19131941"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159090"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_2_1"/>
    <dbReference type="OMA" id="KNVTPRL"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="343"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="422"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="491"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="790"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="896"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="939"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD65436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="967" mass="108687" checksum="F66FD48C386CC246" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8A5</accession>
    <name>M2T8A5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_86191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698615.1">
        <property type="nucleotide sequence ID" value="XM_007700425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8A5"/>
    <dbReference type="STRING" id="665912.M2T8A5"/>
    <dbReference type="GeneID" id="19141097"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86191"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="OMA" id="HVVAFQV"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026321" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="189"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="657" mass="71888" checksum="5AE5E9F22E0C3FCA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8E2</accession>
    <name>M2T8E2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_354694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698643.1">
        <property type="nucleotide sequence ID" value="XM_007700453.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2T8E2"/>
    <dbReference type="GeneID" id="19138316"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_354694"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001366_0_1_1"/>
    <dbReference type="OMA" id="DDYLVIW"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="10">
        <location>
            <begin position="486"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="11">
        <location>
            <begin position="1088"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1231"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1293"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1238"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1309"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD65516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1365" mass="153997" checksum="8E3243124EF53200" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8H9</accession>
    <name>M2T8H9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_35599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698352.1">
        <property type="nucleotide sequence ID" value="XM_007700162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8H9"/>
    <dbReference type="GeneID" id="19138405"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35599"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044999_0_0_1"/>
    <dbReference type="OMA" id="FKRVCEE"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36638" checksum="2344034521FD876D" modified="2013-05-01" version="1">MVAISAVRSHNATLKSVLPNPVAVFVGGTSGIGLFTARELVCHTVSPTVYLIGRNATEASKIVDELREINSASKVSFIQKDISLLKNVDEACNEIKSKEKHVNMLFMTCGYLSVKGRDETAEGLDRKFSLHYYARMRFIQQLTPLMDAAAASNELSRVVAVLDPQAGLRLRGVNFSDLSLKNTFSLKNVLVHASAMLSLSVAHLANQHPKTAYIHAYPSGVETGVTRQLFGPVNGAVKFVLSKLGRLMFVPQGESGERHLFAATSPVYAPRVAAETTNMVGSDGVVGSGSYLLNWNGEILADTDNARKLRDEGGVDKVWQHTEEVMKSIEERGSYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBN2</accession>
    <name>M2TBN2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_169485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698036.1">
        <property type="nucleotide sequence ID" value="XM_007699846.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2TBN2"/>
    <dbReference type="GeneID" id="19132635"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_169485"/>
    <dbReference type="eggNOG" id="KOG2776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240479_0_0_1"/>
    <dbReference type="OMA" id="CYYFVPP"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000748">
        <property type="entry name" value="PHD finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000016">
        <property type="entry name" value="Putative curved dna-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026389" description="PHD-type domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="943"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1187"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="951"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1096"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1227"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD66576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1701" mass="186700" checksum="FFDCDA221C87C323" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCF5</accession>
    <name>M2TCF5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scytalone dehydratase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_178687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696690.1">
        <property type="nucleotide sequence ID" value="XM_007698500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCF5"/>
    <dbReference type="STRING" id="665912.M2TCF5"/>
    <dbReference type="GeneID" id="19133154"/>
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    <dbReference type="eggNOG" id="ENOG502SNND">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101889_1_0_1"/>
    <dbReference type="OMA" id="VWKWAGI"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NTF2-like_dom_sf"/>
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        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD66886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="157" mass="17579" checksum="8BA2CD69F8830CE5" modified="2013-05-01" version="1">MSPPTYEEILNCQTVLFEWAESYDSKDWKRLRACLAPTLAVDYSAFIDKKWDALPADEFVGMVSSTHFLGNPLIRTQHLIGLGTWDKTSADTIVAHLQLRVAHQKYTDETLGDVRLTANDHGTGVLTLKCIQGEWRFAGLIPRSRWSAGDVAKVFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDK7</accession>
    <name>M2TDK7_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_35317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697631.1">
        <property type="nucleotide sequence ID" value="XM_007699441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDK7"/>
    <dbReference type="STRING" id="665912.M2TDK7"/>
    <dbReference type="GeneID" id="19138214"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35317"/>
    <dbReference type="eggNOG" id="ENOG502SPBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_5_0_1"/>
    <dbReference type="OMA" id="EAWWRLS"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="214" mass="24530" checksum="D4FB2F0EC08CE67D" modified="2013-05-01" version="1">MMRAFYQDAHWASLWKGVTLDTIIYDCARRLPWNIVKVTSPKRHRKVVEEATGNVVGYARWIIPDGHVDTWANGIVLETDLEKRQAYEQAFQDVTDDGKIRGIDHQMVDELSEAIEKAEAEVLSTGEEFLILDYLATHPEHQRRGIGSMLLAEGLAYADRNSLRTIVVAKTPGVKLYQDHDFQVIKLVQQERPQYGWSKPYTTTILIRQPKPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TE30</accession>
    <name>M2TE30_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydantoinase/oxoprolinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_23446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696421.1">
        <property type="nucleotide sequence ID" value="XM_007698231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TE30"/>
    <dbReference type="GeneID" id="19134842"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_23446"/>
    <dbReference type="eggNOG" id="ENOG502QQBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007154_0_0_1"/>
    <dbReference type="OMA" id="WYISETD"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.390.10:FF:000002">
        <property type="entry name" value="ACR027Cp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="209"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="603"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="4">
        <location>
            <begin position="768"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="993" mass="105965" checksum="FE1AA6DE9AA979F3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEN6</accession>
    <name>M2TEN6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_136919</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697286.1">
        <property type="nucleotide sequence ID" value="XM_007699096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEN6"/>
    <dbReference type="GeneID" id="19131030"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_136919"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_8_1_1"/>
    <dbReference type="OMA" id="PMGIKYA"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="262"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD67691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="667" mass="72947" checksum="DB723676ED661092" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2TG80</accession>
    <name>M2TG80_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_33202</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
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    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
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    <dbReference type="STRING" id="665912.M2TG80"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_33202"/>
    <dbReference type="eggNOG" id="KOG0420">
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    <dbReference type="OrthoDB" id="10249039at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD68251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="183" mass="20716" checksum="3D7CCBB419520E19" modified="2013-05-01" version="1">MMKIWSMKKQQQQDEAAAAASSKKKKVTPAQLRTQKDLEELSLGTTMKTHFPNPDDILNFELTIDPDEGMYKGGRFKFDFKINQNFPHDPPKVKCTQKIYHPNIDLEGNVCLNILREDWKPVLNLNAVVVGLQFLFLEPNASDPLNKEAAEDLKANREGFKRNVRASLGGGTVKGQSFDRVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2THC7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_274808</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THC7"/>
    <dbReference type="GeneID" id="19135684"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_274808"/>
    <dbReference type="HOGENOM" id="CLU_139867_0_0_1"/>
    <dbReference type="OMA" id="AETSWHA"/>
    <dbReference type="OrthoDB" id="10379326at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="153" mass="16464" checksum="A5F338C9EDCD8D3C" modified="2013-05-01" version="1">MWCRLGSWHEHGQVRYIMSLRAEDQETRVIGGIAGGGEPAAETSWHAVKRGKRDFYLPGAGCGTGGSRHPQMNGHAREAGGIPPTNVMVVMMLGTGMGTRRMKSMTMQLMQTMARQDPPDATQTQRRCNASVRAGQMGGQSGSHVLRAATIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2THD5</accession>
    <name>M2THD5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_109395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696195.1">
        <property type="nucleotide sequence ID" value="XM_007698005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THD5"/>
    <dbReference type="STRING" id="665912.M2THD5"/>
    <dbReference type="GeneID" id="19130090"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_109395"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_5_2_1"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000004">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="300"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="518" mass="56582" checksum="1145FC71CDFB9B01" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2THI0</accession>
    <name>M2THI0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_275666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696234.1">
        <property type="nucleotide sequence ID" value="XM_007698044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THI0"/>
    <dbReference type="GeneID" id="19135704"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_275666"/>
    <dbReference type="HOGENOM" id="CLU_2263525_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="103" mass="10809" checksum="A27A91CDAE9AA6FE" modified="2013-05-01" version="1">MGGLRRGPRSVMLLSYGNKTRKIACGSACGFPGCGWVGLARLRYSGEGEKIGRIDDLVRGAACLTLDLFCTPLCACMGLGGWAWFGLVGGRLSWACGLVDCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2THX5</accession>
    <name>M2THX5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">COCSADRAFT_33246</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695490.1">
        <property type="nucleotide sequence ID" value="XM_007697300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THX5"/>
    <dbReference type="STRING" id="665912.M2THX5"/>
    <dbReference type="GeneID" id="19137103"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33246"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="22">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMD68307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="151" mass="17098" checksum="89366A4458E79CA6" modified="2013-05-01" version="1">MSTAARRRLMRDFKRMQTDPPAGVSASPVADNVMTWNAVIIGPADTPFEDGTFRLVMHFEEAYPNKPPGVKFISQMFHPNVYGTGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNTSSPANVEASNLYKENRKEYTKRVRETVEKSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI25</accession>
    <name>M2TI25_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_33726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695613.1">
        <property type="nucleotide sequence ID" value="XM_007697423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TI25"/>
    <dbReference type="STRING" id="665912.M2TI25"/>
    <dbReference type="GeneID" id="19137283"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33726"/>
    <dbReference type="eggNOG" id="KOG2908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042989_0_0_1"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="177"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="383" mass="43992" checksum="0E5D2DB280F165D6" modified="2013-05-01" version="1">MAMDTDAIPNLLGDARDEAPEELQEYFIAFEDFWERKLWHELTDKLIEFFDHSGSAKQRIPFFENFIKTFANKINQLKLVTLGLNAASQYQDDKERLAFVNELAKSVNKPASQDAYVYATVAAASIQLRLRDEEGAKKKLDECEQIIDQFDSVETVVHASFYRASAEYYKSKHEFAAYYKNALLFLACVDLNDLELRERQSRAYDLSIAALVSDSIYNFGELLLHPILDSLVNTPHAWLRDLLFAFNRGDLMAYDVLSNNITKVPLLKEHQTFLYQKISLSALTETVFRRPPHDRAMTFSEISQETKVQPNEIEHLIMKALSLGLLKGQIDQVAEIARINWVQPKVLDMKQIEGMRTRLKEWDASVNQLGNWIEGVGKDVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIF2</accession>
    <name>M2TIF2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-2-oxoglutarate aldolase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_33387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695530.1">
        <property type="nucleotide sequence ID" value="XM_007697340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIF2"/>
    <dbReference type="STRING" id="665912.M2TIF2"/>
    <dbReference type="GeneID" id="19137154"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33387"/>
    <dbReference type="eggNOG" id="ENOG502SG3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="OMA" id="KHAVACY"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF47">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33228" checksum="F47C9C4607F2686A" modified="2013-05-01" version="1">MAPPPAPGVWCPAVTFFTPDSETATLDLVAQKQYFTYLSKSGLTGLVILGSNAEAFLLTRDEKRALMKCAREAVGPDYPLMVGISGFSVPQVLENISDAIEAGANYGLLLPAAYYGPATSKEVVMAFYNEVAQKSSLPVVIYNFPGICSGVDLDSVTIAALAQQNPGKIVGVKLTCGSVAKITRLCAELPSDMFSTFAGQADWMIAGLAVGSAGCVSAFSNVFPKVCSKIYELYTSGKTKEALELHRKAALAESPIKAGIAPTKHAVSQYSAKAAGIEGAEERLNPRRPYMPVGEALKTSVKNTMGELAAIENSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJP3</accession>
    <name>M2TJP3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_32137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694211.1">
        <property type="nucleotide sequence ID" value="XM_007696021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJP3"/>
    <dbReference type="STRING" id="665912.M2TJP3"/>
    <dbReference type="GeneID" id="19136657"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32137"/>
    <dbReference type="eggNOG" id="KOG3904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018689_0_0_1"/>
    <dbReference type="OMA" id="IIMFPPQ"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="380" mass="42024" checksum="8BEDEB4611306F61" modified="2013-05-01" version="1">MSTKSDHQSPKKPAKSPVVPRPSASVLLISPTNQILLLHRVSKASTFASAHVFPGGAVSKTHDGEMPGPDHPDRHRDGPAYRMAAIRETFEECGIVLAKSKKTGRLFTEISDEEREQGRKAVHNGEIKFGDLLEKWGAVPDTESLIPFTRWVTPAVTPESLPKRFTTQMYIYLLPLGSVSPTKHAAPRGTPPSSGLEEEAEIIIPKPRHDGGIEHTAARFLPPNKWIDLARQNRIILFPPQFFLTLMLSPYLASTVTSSSSPTPSLSELQAERDRLLDFLQKPRIYNGQPEVPFTEACISPIVLGEGEYGESKQDGIGGVDKSTAVLVLDRPGKEVEEQGQGRRGIREWVITAKFKKEGPRDVDVRRREEILGKEVKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK11</accession>
    <name>M2TK11_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_210826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694816.1">
        <property type="nucleotide sequence ID" value="XM_007696626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TK11"/>
    <dbReference type="STRING" id="665912.M2TK11"/>
    <dbReference type="GeneID" id="19134398"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_210826"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_0_1_1"/>
    <dbReference type="OMA" id="CVGEHKD"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="7">
        <location>
            <begin position="170"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="476" mass="52865" checksum="7BF2BB5F73EC2691" modified="2013-05-01" version="1">MSAMMLRRQNLQRFQRLALSQTSRSLSQTPRYVHQSARQNVSVPTSSPTSDLLSSQPESHIAQTKSVLGRLPTSTVLRSYLITAMSSQPLLLNACFGLLRRMLESKSYIMSIERNPVLSNLLKKTFYAQFCVGEHKDEVVRNTEFARTLGYGGILFEYALEVLGGEAPTAAETKKEIEVWRKGMLQSVDMAKEGDFVGLKWSGLGRHALQLLQNQQDATPEMWDAITAACDAAAAKGVSLLPGAEEEATNLGLEKWTLALQKKYNTPERGHAVLYITYQCYLRNIAERLAQHLEMASKGGYIAGVKLVRGAYLTSEPKHLTFDTKAETDANYDAIADAVVRQQWTDKVSAPTPGTPFPKVNIVLATHNLASVKAAQKIRASQMLTTSPEKLPRLTYAQLQGMADEISQALVQDETMKADKQAKVVKCMTWGTTAECLNFLLRRASENKEAALRTEDTRRAMGKELWRRLKGTFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKE2</accession>
    <name>M2TKE2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_32320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694259.1">
        <property type="nucleotide sequence ID" value="XM_007696069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKE2"/>
    <dbReference type="STRING" id="665912.M2TKE2"/>
    <dbReference type="GeneID" id="19136728"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32320"/>
    <dbReference type="eggNOG" id="ENOG502R216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035067_0_0_1"/>
    <dbReference type="OMA" id="PRGFHEV"/>
    <dbReference type="OrthoDB" id="3776883at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="501" mass="56833" checksum="E7C489A659FAB41C" modified="2013-05-01" version="1">MSTVTQDEVIKASLLTPFKYLAENSKPMKRKFSMLIRWYFLIQGLIDGLEGDQGDFCKRFSSAVKRIDEEKHDEEDGTQNRTRRNREAIEESPEPEDADSTYTLRSSSRTGKTHVINGEKPEPQSPSVRSSRDLRNSKGNHDLERLLEYLNNHNALYLLDNLPEVSEVQFVGQTSIPEAQPMKLFVGREAKSGDDIYAYMVSLPRGFHEVRFYVQTAHDEEPMKTETVAKQRLIHPFSKCYPKQPCVLEQSDRARLTLMVKFYFISAGIATDCVLKETKKYPERLRVALDYIADRMGPAAAKPPSHTKDEDDDAATADAAPAPNNPPKHRLSSESSYIDESDIQSTLALEPPRLPHSHNRTPKPPVFARKSTYSIAPRQGTSQPPSRTTSPSTFLPPTTDATTTDTSSPAIQPLRGNPKRSAEDAEFEDLARIVMKEQTLTREIHALQHEMDVLEERKTIWMEKWQAQFQSVNEKLEAVTRERVGVRMQFKKQRLGGGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2TL02</accession>
    <name>M2TL02_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_32092</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694199.1">
        <property type="nucleotide sequence ID" value="XM_007696009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TL02"/>
    <dbReference type="STRING" id="665912.M2TL02"/>
    <dbReference type="GeneID" id="19136642"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32092"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080880_0_0_1"/>
    <dbReference type="OMA" id="YSEHYFN"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000004">
        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD69362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="200" mass="22265" checksum="0B2F9163A2A09773" modified="2013-05-01" version="1">MRPAATRFASVIARRALRSPLRDQLPVGRVIASRAPVTTNTTCFRPLHVSASLRSIMPDSEDPKPPELPSQETPAKATDISMQEFHERADHYLGELQQRLEEAQENDPAIEVDYSAGVLEVTSQNNTFVLNKQPPNKQIWLSSPISGPKRFDWVVSQEGMGEKEGCGIGDWVYLRDGSSLTEILRKELGVDVSVDDEVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSQ7</accession>
    <name>M2QSQ7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_49884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445661">
        <property type="protein sequence ID" value="EMD58214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706086.1">
        <property type="nucleotide sequence ID" value="XM_007707896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSQ7"/>
    <dbReference type="STRING" id="665912.M2QSQ7"/>
    <dbReference type="GeneID" id="19140267"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_49884"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1726616_0_0_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16803" checksum="04F2C5977EE20091" modified="2013-05-01" version="1" fragment="single">FYKTGDIAYFSTDGSLIIVGRKDNQVKLHGQRIELGEIEFQMRAVLGKSVTSVAVDVLGPATNNIQTSLVGFIENSSASVETDVQRNDGGRTDVNEDNQGKTMLYDIPPVRLEAIREALRAKLPSYMVPSTVWSLNTFPKLPSGKMDRKTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2QV79</accession>
    <name>M2QV79_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_348498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705478.1">
        <property type="nucleotide sequence ID" value="XM_007707288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QV79"/>
    <dbReference type="GeneID" id="19137898"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_348498"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037774_0_0_1"/>
    <dbReference type="OMA" id="SSKEAGW"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001190">
        <property type="entry name" value="Short-chain dehydrogenase/reductase SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF15">
        <property type="entry name" value="OXIDOREDUCTASE UCPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="507" mass="53037" checksum="A516F6C7258962AB" modified="2013-05-01" version="1">MRFTELSAALLLAPLVAAHGGGHTPKIVGSGSKDIGKLRSRNILDSRAPRVAGPEKALSKRQGGADGRCGAEHGNASCAEGYCCSTAGYCGQGSDYCAAPDCRFQYGPACDANQVPTGGSTRNTPRTKLGNQPYGGEGIYDCIVPNTIAITYDDGPYIYTSGVLDQFAAYNAKATFFVTGININKGAIDDKSTQWPSIISRMIAEGHQVASHTWSHQDLSAITKEQRYDQMVRNEMALTNIIGKFPTYMRPPYSSCTAGSGCQKDLTDLGYVVSYFDLDTDDYNNVTPDLIQNSKNRVGAAINPSNPAEDNFQAIAHDIHQQTAQNLTGYMLDLMTQKGYRLVTLGECLGDPEANWYRTPTSRPASSSVFTPPASSTASGAASATSSGAVVTPTAVSPDSSCGSKVGYTCLRFAQGECCSQYGFCGNTADHCGTGCDPKFGKCSVAGSSAPVSPASSTVSGSTRPASSTGSVLPTPSPSNGVSQDGSCGGEKGYTCAGYFEGECCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2QVW2</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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    <dbReference type="eggNOG" id="ENOG502S4C9">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
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        <property type="entry name" value="BC10"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_175927</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
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        <property type="nucleotide sequence ID" value="XM_007706926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QWB6"/>
    <dbReference type="GeneID" id="19133001"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175927"/>
    <dbReference type="eggNOG" id="ENOG502SAX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="OMA" id="RWKNGSN"/>
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    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="424" mass="47060" checksum="683DB5DA33A85DBD" modified="2013-05-01" version="1">MDPLSATASVIAILQLSAKVLSYLNDVKDASKGRAQCAIEASNLHNLLTNLRFRLEEGHGHQPWFSAVQALAVENGPLDQFKQALETLQAKMTDGGRLKKVNQALIWKFKKEEVDTILARMERLKTLVEIALQMDHLRARKLSQAIKDDTGSIRTHVSAIESAVNKVQQVQVTATQRILLEWISSSDYPAQQSDIIKRRQEGTGQWFLHAPEVARWLGDAKTTLFCPGIPGAGKTMVAAIAVDQLLDLAQNGAYGVAYVYCNYKSQADQDIVSILAAILKQLVQSRPSALGPVERLHQKHAGRGTKPSLDDIYSTLRDVLTQYPYVHIVVDALDECQNETRRQLCTKLFDLQKGADMRLMVTSRFVPDVEDAFRLASRLEVEASDEDVKQFVAGQIHRLPGCVQRSAALQKLVQERVVEAVGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2QWN5</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_250745</name>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704551.1">
        <property type="nucleotide sequence ID" value="XM_007706361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QWN5"/>
    <dbReference type="STRING" id="665912.M2QWN5"/>
    <dbReference type="GeneID" id="19135209"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_250745"/>
    <dbReference type="eggNOG" id="ENOG502RZF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026455_2_0_1"/>
    <dbReference type="OMA" id="ININRWT"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="595" mass="65640" checksum="59492C0D4978F3D4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2QX58</accession>
    <name>M2QX58_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_40809</name>
    </gene>
    <organism evidence="9 10">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <property type="nucleotide sequence ID" value="XM_007705288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R1N7"/>
    <dbReference type="STRING" id="665912.M2R1N7"/>
    <dbReference type="GeneID" id="19132917"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_174485"/>
    <dbReference type="eggNOG" id="KOG2491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017925_1_0_1"/>
    <dbReference type="OMA" id="EYHTENV"/>
    <dbReference type="OrthoDB" id="10257415at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="69942" checksum="4DF88D0BC91C5AEB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2R468</accession>
    <name>M2R468_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_38789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702116.1">
        <property type="nucleotide sequence ID" value="XM_007703926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R468"/>
    <dbReference type="STRING" id="665912.M2R468"/>
    <dbReference type="GeneID" id="19139343"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38789"/>
    <dbReference type="eggNOG" id="ENOG502S1Q4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="OMA" id="GIWDRAD"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="352" mass="37040" checksum="E962A26D53EAB140" modified="2013-05-01" version="1">MAPPVLQTPLSQLLGIQYPIILAGMARTSGGPLAAAVSNAGGLGVIGGLGYTPAQLQSIIDDLKSNLNDQNLPFGVDLALPQVGGSARKTNHDYTHGQLDELIEVTIKNGAKLFVSAVGVPPARTIKRLHEAGILIMNMVGHPKHAKKALDAGVDIVCAQGGEGGGHTGDIANSILIPAVVDVARKYKSPLTGEPAMVVAAGGIYNGRSLASSLMQGAQGVWVGTRFVASTEAGCSKMHKENVVTADFTDTGRTLVVSGRPLRVRYNDYIKEWHQREDEIKKLTEAGIVPIAKDMDDGKDVDIPFLMGQVAGVIDDIKPAKQIVDEMVQEAVDMLRLGQTYIGGAAGVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2R6G5</accession>
    <name>M2R6G5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_173170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702029.1">
        <property type="nucleotide sequence ID" value="XM_007703839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R6G5"/>
    <dbReference type="STRING" id="665912.M2R6G5"/>
    <dbReference type="GeneID" id="19132835"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_173170"/>
    <dbReference type="eggNOG" id="ENOG502SJG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_0_1_1"/>
    <dbReference type="OMA" id="VPIREWI"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="279" mass="31676" checksum="524234DBF59FD82D" modified="2013-05-01" version="1">MIGPPITRRNVSDVQQAEIPKLIWYKLGPNGLSDEARAWTDSCVKNNTGYKAHFLTDEGSDTYVRKTFAFRPDIVDTYLALPIPIFKADLLRYLLLWDQGGIWSDLDVSCEDIPIDDWVPASYKNSAAIVVGWEFDQGWPGKYVRQFASWTIMSKPRSPHMMQVVDDILETLRVETTEHGIGVQNVTLEIMGDVVDFTGPRRLTRSLFKSLEKQMNRTLDVSEFHEILQPRLVGDVLIMPGQSFAASSNTYTVEQQKDLPPQLVEHHYAGSWKNDKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2R7R5</accession>
    <name>M2R7R5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">COCSADRAFT_37897</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701028.1">
        <property type="nucleotide sequence ID" value="XM_007702838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R7R5"/>
    <dbReference type="STRING" id="665912.M2R7R5"/>
    <dbReference type="GeneID" id="19139122"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37897"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="OMA" id="VKQMQVW"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="40"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="338"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD63024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="494" mass="53206" checksum="49A2A83F59A0FF69" modified="2013-05-01" version="1">MPPRISLASSRALSSPLTRCVRLQPQRRFLSSSADAPEVYDVVCVGGGPAGLSLLTGLKASPITNGLKVALIEGQDLHKSRLAQDASLETFSNRCSSLTPASVRNLQEIGAWAHVNQPRVQPYQEMQVWDGVSGARISFDWHTAKPLLTPRNPAQPTTIAYMIENVNTVTALLSRLEELGGVDFYTSTKVSSIDLGTDTDKMDFSSWPILTLSNGKSLAARLLVGADGANSPVRTFAGIESRGFDYNRHGVVASLKLEGQGWGREGHKIAYQRFLPTGPIAMLPLPGNMSTLVWSTTPERAAKLKALSQQEFVAMVNAGFRLSATDLEYLHTLSSGHEEEVAWREKHTPVDEHAIPMWVTNVQAGTVASFPLRMRHADTYTGERVALVGDAAHTIHPLAGQGLNQGQGDAAALVRTISYAVQTGQDIGSTLALESYNSERYAENNAMLGVCDKLHRLYSVESGPLVGLRSLGLRAVDSMGPLKGFFMSKAAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2RAL8</accession>
    <name>M2RAL8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_144477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700899.1">
        <property type="nucleotide sequence ID" value="XM_007702709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RAL8"/>
    <dbReference type="GeneID" id="19131315"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_144477"/>
    <dbReference type="eggNOG" id="ENOG502SKMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_31_1_1"/>
    <dbReference type="OMA" id="DAKCIPT"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="66"/>
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    </feature>
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            <end position="110"/>
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            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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            <begin position="234"/>
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        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD63924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="385" mass="43269" checksum="6A3E83C346E2CB7F" modified="2013-05-01" version="1">MALSNLQPLAYVVAYITFAFGTISIFLRFYCRRYILHLWGWDDHFAVLILVFSIGQQVILHMFLYWGCGLRMATLTTHQQLQILKWLFIEQVAYYSVHWVIKSAFLLFYLRLSTRKPFRIAICIGGAINGTILIINTLMACFQCVPFDEILHPGTHPNAVCINRLAMLIVPSVLNIFADFYILILPIYTVWHLQMTLGRKLRVIGVVAFGSSSVIIACFRLIPLFELFRSPDTSWVLGKMVIIAALEIQCAVIAVNLPSLKPLWTRMMGDSSSGSGPGGDSDSNKKRYRLSSRGHIITFGSEGRELRAGKWAKKSHRGSVARTDQGLTVTESEEELCRQGGISLRMLNQMSAGEAGAIKIQKDIHIQSSEGDSDKVITENYISRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">COCSADRAFT_62413</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19140395"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_62413"/>
    <dbReference type="HOGENOM" id="CLU_2984451_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="58" mass="6700" checksum="2B19F96B5CDF946D" modified="2013-05-01" version="1" fragment="single">MTYAQQEQERQANKSRRPAPTYRLRPAANDPFPSQQTDDTNPTATVVQDNENNEEHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RB98</accession>
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            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_117101</name>
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    <organism evidence="3 4">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699986.1">
        <property type="nucleotide sequence ID" value="XM_007701796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RB98"/>
    <dbReference type="GeneID" id="19130349"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_117101"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_3_0_1"/>
    <dbReference type="OMA" id="KMVTMFS"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="319" mass="35608" checksum="BAF5C25D8D4CD144" modified="2013-05-01" version="1">MAYQRKKSLLIGINYVGSSHELRGCHADVDNMAEFLYYRGYNNSPQDRVILTDRPEVPPDSPYYPTGHNMLAAMDWLVSEPGCTLFLHYSGHGGQIADTDGNRTTGLDASLVPIDFEQRGQISSTILHQHLVTRMARDCTLFVIMDCCHSGSALELPYVYRSDSDGQISLMDNLKTGLHLAEEARDIISGGFTFDKVGEAQQLLAGASSFFKGLRHMGEEQEEGLEDGEFADQYGHERKMVTMFSGCKDEQTSADAQIEGRATGAMTWAFLEMMKSTERPSYAETLKHTRKLLDESNYTQIPQLSCGLDIDLDEMTLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2RCS7</accession>
    <name>M2RCS7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_357694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007702137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RCS7"/>
    <dbReference type="GeneID" id="19138518"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357694"/>
    <dbReference type="eggNOG" id="ENOG502QWK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038069_0_0_1"/>
    <dbReference type="OMA" id="VCSHNAS"/>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62520" checksum="74914B7C77791BF8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2RE20</accession>
    <name>M2RE20_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_36367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700962.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19138715"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36367"/>
    <dbReference type="HOGENOM" id="CLU_2096691_0_0_1"/>
    <dbReference type="OrthoDB" id="3801583at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="116" mass="12786" checksum="360B4D6609E6E303" modified="2013-05-01" version="1">MPTNSTDETSRKNERSMHKPTSDDENIARLRGGAGTSQARHGCSLLFKQLLLTCHRPDSNSSSDTEDSPIRIRDPTYIARTMRRAQGNARLPKNLSRTTATSRTTRSSSSNGNVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2RHJ3</accession>
    <name>M2RHJ3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_137577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD66209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697759.1">
        <property type="nucleotide sequence ID" value="XM_007699569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RHJ3"/>
    <dbReference type="STRING" id="665912.M2RHJ3"/>
    <dbReference type="GeneID" id="19131058"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137577"/>
    <dbReference type="eggNOG" id="KOG2581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019858_1_2_1"/>
    <dbReference type="OMA" id="AKVYFYF"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="251"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD66209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="505" mass="57278" checksum="B9EB4CC61CEA4F90" modified="2013-05-01" version="1">MADSMEGVVTAGEAPKTENVEQKAIADIRSNFVLLERAVAQFDTRFTLRALRSISSLRKRLTDRVLCSVVILTYSPNNATARTFIEYIGMDGEAIQSVVSQYKEEVQLNKNSTKEPLPEVDIYIAILIQVYLYDQKEFEEGAEFSEKLVDKIRELNRRTLDSLAAKAYFYFSLFHEEMDPKPPSKQSPVITIRGKLLAALRSAVLRKDPDTQASVTTLLLRNYLSTADITQADLLVAQTQFPPNAPNNQVARYLYYLGRIRAIQLSYTEAHEHLTSATRKSPSAHCATGFYQASMKLLCVVELLMGDIPERDVFSQPRLERAMEPYFRLVQAVRVGDLQGFLKVVQQSSSIFHRDGTYTLILRLRQNVIKTGIRMLSLSYSRISLRDICIRLGLESEESAEYIVAKAIRDGVIEASIDHEKGFMQTKVAGDIYATREPGEAFHERIRACLTLHDECVKAMRYPMNQHRLELKNAQEARERERELAKEIQDGDIDEDDAAGDFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2RHR4</accession>
    <name>M2RHR4_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_158415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697820.1">
        <property type="nucleotide sequence ID" value="XM_007699630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RHR4"/>
    <dbReference type="GeneID" id="19131895"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_158415"/>
    <dbReference type="eggNOG" id="ENOG502SR1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906178_0_0_1"/>
    <dbReference type="OMA" id="DPGYDCD"/>
    <dbReference type="OrthoDB" id="4186058at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="304" mass="34746" checksum="D8AF86ADF8E02544" modified="2013-05-01" version="1">MAQHHQPPVTTLNGHLQSPPMTPSPEAHSRFPPPPRQSSPQYKRMASCVQTPPLEYIEPTGFNHQFSFTRPQPCEPCSRPSSDSDQAFAATTCEDSEFECDSDDENDSDQESEPEEQPPLRRVEKAQFILEELDDDPGYDCDVEVLQPDHCEDAKSERNGVKAEIFARMNELQLEEDSSDDEKRVLKYRQKKKRWSAGIFKKRSYSQSVEGDSDYSDNDPLDDMDPSARRLRRRVRGPRRESLIFVDRGVSNTNNILEVEEPEEGIVLHSKGPPSIPSDDGFTLDELPFWTAHDNIDIEYSIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RHR8</accession>
    <name>M2RHR8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_188674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697824.1">
        <property type="nucleotide sequence ID" value="XM_007699634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RHR8"/>
    <dbReference type="GeneID" id="19133640"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_188674"/>
    <dbReference type="HOGENOM" id="CLU_519695_0_0_1"/>
    <dbReference type="OMA" id="HHRPCAL"/>
    <dbReference type="OrthoDB" id="3779310at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="544" mass="60313" checksum="33416BD169755B5C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RHW3</accession>
    <name>M2RHW3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_34911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697527.1">
        <property type="nucleotide sequence ID" value="XM_007699337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RHW3"/>
    <dbReference type="GeneID" id="19137940"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34911"/>
    <dbReference type="eggNOG" id="KOG2432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534259_0_0_1"/>
    <dbReference type="OMA" id="EANLEHW"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="22"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="503" mass="56025" checksum="4FAB2E99917DFC38" modified="2013-05-01" version="1">MDKLREPKLSPIATGGFRHWAVAFIVCNFNVDIGPEIEILYPPHIPFSTSDLSAICFNSFPEQQNTETAEDLCYDFAITNNSPDIQLTSPNAPHGSAVTFYASCIFRQEFDDTMKRSFNQRALVLISHHNFTALNHRILQKMTESGHLSDPTTLEAAYKQMNNWMPPALGHHNLPFLGSMLRLDIAPHRAFPLQGLPGPNPLMSDTAQSIYAYEPIGYWDSIMHYMPCITDLYVLYEKLILCESVIVIAKSPQLASEAVSSLLDLICPVPYAGVVRPYMTMQANFKSIGIDGGTPTSFIAGVTNPFLLKRIIAAVEASHQARPHILYLQNFDGPVPMRRHHSLHHKSSRNALLDLPGGGIEVHTPPKRFLKSDPTVVSQIDALLKLGDQTQDLGPIIRRHFAELTAQFIAPINRYLATSHVVTPGGNSRYASFQVREFLSSVSKHGTSVKFRGSNPLQRHRARDGMYETFCNSPNFYSWLEMKISLENEASAGMLNAPVVHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2RM90</accession>
    <name>M2RM90_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_82727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697319.1">
        <property type="nucleotide sequence ID" value="XM_007699129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RM90"/>
    <dbReference type="STRING" id="665912.M2RM90"/>
    <dbReference type="GeneID" id="19140912"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82727"/>
    <dbReference type="eggNOG" id="ENOG502SEUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106353_1_1_1"/>
    <dbReference type="OMA" id="KRPFKMS"/>
    <dbReference type="OrthoDB" id="3990500at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024974" description="FUN14 domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17458" checksum="A11C3EA653E4B79B" modified="2013-05-01" version="1">MLFILPGLRRGLMLSTPLILSTPLLAHQFRNAQRIRCDGPDPITKITSDLKSNYAAEARTPVITQSGAVNPRAIRQISMGSILGVIGGLGISVFSKPLAILIGLGIFAVQFIESRGIHIIPYSFLQRRLKSMNVRSLVQDNVAFKLSFGLTFAMAAFAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2RMD9</accession>
    <name>M2RMD9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_83062</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697355.1">
        <property type="nucleotide sequence ID" value="XM_007699165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RMD9"/>
    <dbReference type="STRING" id="665912.M2RMD9"/>
    <dbReference type="GeneID" id="19140931"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_83062"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_127_1_1"/>
    <dbReference type="OMA" id="QDSKCEQ"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="135"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD67794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="420" mass="47748" checksum="D2A86CCF190E8DA6" modified="2013-05-01" version="1">MTSRISSMMGIKSSTNADKNGDVKATNGATANGRPPPVRQGSINRKDVPTAPYKRFWLNEDGSHEHHLKVAKRQEKLSDMFQNLMLGKKKGEAPEDQPLSLMSNWVDVMRNEKEKLAEQKNAVNALPQTLVQKYGKCQEVVGRGAFGIVRVAHKQDPKDSKREQLYAVKEFKQRPGESAKRYQKRLTSEFCISSSMQHPNVITTLDLLQDEKGTYCEVMEYCSGGDLYTLVLAAGQLEVAEADCFFKQLMRGVEYMHEMGVAHRDLKPENLLLTTHGSIKITDFGNGECFRMAWEKEAHMTAGLCGSAPYIAPEEYVDKEFDPRAVDVWACGIIYMAMRTGRHLWRVAQKGEDEFFDRYLEDRKQEEGYRPIEVLRRRQCRNVIYSILDPIPARRLTAHQVLASEWVSEAKVCRAGNEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RNI3</accession>
    <name>M2RNI3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_167448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695863.1">
        <property type="nucleotide sequence ID" value="XM_007697673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RNI3"/>
    <dbReference type="GeneID" id="19132516"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167448"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043418_1_0_1"/>
    <dbReference type="OMA" id="QANEKFY"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="331" mass="36220" checksum="593416A53F1C2515" modified="2013-05-01" version="1">MTLLHTLLRATAFKNPLLRTLVPTVALAYGIQAAVAIPSITAQTERYYDLSGSLTYLSCTALSLTLPYLRARAAGTATNGLVDYFGNQGLGQGTTWWWRQALLSAAVGLWATRLGSYLFRRISSDDGKDSRFDSIRSSPPKFLVAFFAQAAWVSLCTLPVILVNSVPRSAYASSLLGQAVSSKPYLTDILGLAIFVFGLGFEVVADRQKDAWVQAKKAKKHEEQFLTHGLWAMSRHPNYFGEATLWSGIAVAAAGLLVRQPAQTALGLSGGLSGKMLVTGMCVASPAFVSFLLLKISGVPLSEEKYDKKYGGDEEYQRWKRETPMFFPKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2RNQ4</accession>
    <name>M2RNQ4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_270975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695920.1">
        <property type="nucleotide sequence ID" value="XM_007697730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RNQ4"/>
    <dbReference type="GeneID" id="19135615"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_270975"/>
    <dbReference type="eggNOG" id="ENOG502SD7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891800_0_0_1"/>
    <dbReference type="OMA" id="PPDTMES"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="384" mass="42581" checksum="E129C5712FAC171B" modified="2013-05-01" version="1">MKLKMLNGAPRREHLDFSDSCLLPADECNGFSVAARCEMPPVDSTPTMKWRCLAKKDTRLQSEWQHPYLPGSILGSHMADISLPEVVQFQSFAQEDTTALDATVSFNDPTFNTDGLIEHSLVFHDSLLSSQVVPGEGPDSTINSSSFLSTSFETTTSDYSSPHKADQHTIIHVPLKLSITPLASLPSAQQLRAIYPQTPTPNFICVVTTSPEKREIFVRRGGYKMDLWEIIVADDSFSGFKTAFWMRPNLDSKDERTRSQRSLLEALQGIKVGDIILLTNVALTSFRDTVFGQSLNPAIARARTDIHVLMKSNGISAAQPGRLPSQVDEAFTRVKKWARMHVASDIGGSRKRKGSAPKQGDFVKRTFATRDLDDSMPPDTMESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RNX0</accession>
    <name>M2RNX0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_108716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695966.1">
        <property type="nucleotide sequence ID" value="XM_007697776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RNX0"/>
    <dbReference type="STRING" id="665912.M2RNX0"/>
    <dbReference type="GeneID" id="19130068"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_108716"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SM22CALPONIN"/>
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        <property type="entry name" value="CH"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
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        <location>
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            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="667"/>
        </location>
    </feature>
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            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="405"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="667" mass="75180" checksum="2CF1E553534B5DCF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQD4</accession>
    <name>M2RQD4_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_23192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697193.1"/>
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    <dbReference type="eggNOG" id="KOG2372">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
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    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TLDc"/>
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    </dbReference>
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        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="139"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="363" mass="39431" checksum="D1585C659CACB329" modified="2013-05-01" version="1">MSHAQETPSSPPLRSSSSQTSPPPNRATPNRSSSYFTYPVSYAVSGILRRLNTESSPNPGPHSKSDSNSNRNSIGRLPAQLQSTASALSHSLASLVSSDSVDMNSVFQPTHRIASPFQPPPLTPLSLKGWRSGMRENGKLLSKALAEEIRLLLPPRLQLVDEWSLTYSLEQNGVSLATLYKEADEYRGRRGGFVLVVRDGSGGTFGAYLSDAPHPSSSFYGNGECFLWRAQILAGLPDLQLNLPPPPSEDTTNAVRMTTISSPKTKADKLALSENDQATRSGASTPERIRFKAFPYSGVNDYMIFCEHSYLSVGGGDGHYGLWLDDNLENGVSDTCPTFGNEPLSDEGKKFEVLGVELWYIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQM4</accession>
    <name>M2RQM4_COCSN</name>
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        <recommendedName>
            <fullName evidence="6">Vps41 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_109913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696370.1">
        <property type="nucleotide sequence ID" value="XM_007698180.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2RQM4"/>
    <dbReference type="GeneID" id="19130107"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_109913"/>
    <dbReference type="eggNOG" id="KOG2066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001285_0_0_1"/>
    <dbReference type="OMA" id="CYIRLQD"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000510">
        <property type="entry name" value="Vacuolar assembly protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="6">
        <location>
            <begin position="172"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 beta-propeller" evidence="6">
        <location>
            <begin position="385"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="909"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="1189"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="881"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1334" mass="145737" checksum="F44E68F5B746307C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQV7</accession>
    <name>M2RQV7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_130198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694434.1">
        <property type="nucleotide sequence ID" value="XM_007696244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQV7"/>
    <dbReference type="STRING" id="665912.M2RQV7"/>
    <dbReference type="GeneID" id="19130776"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_130198"/>
    <dbReference type="eggNOG" id="ENOG502QQBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009030_2_2_1"/>
    <dbReference type="OMA" id="NPWRTTY"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD68964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="651" mass="72661" checksum="623129A5E88BFF08" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSZ8</accession>
    <name>M2RSZ8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_61297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694415.1">
        <property type="nucleotide sequence ID" value="XM_007696225.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSZ8"/>
    <dbReference type="STRING" id="665912.M2RSZ8"/>
    <dbReference type="GeneID" id="19140386"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_61297"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="OMA" id="WSMGPFF"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="180"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="651" mass="70887" checksum="4264E8E45F7DBB9A" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT60</accession>
    <name>M2RT60_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_76878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694982.1">
        <property type="nucleotide sequence ID" value="XM_007696792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT60"/>
    <dbReference type="GeneID" id="19140585"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_76878"/>
    <dbReference type="eggNOG" id="ENOG502T5N9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811338_0_0_1"/>
    <dbReference type="OMA" id="ACQPFGN"/>
    <dbReference type="OrthoDB" id="3942472at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41440" checksum="E54B47AC57FA5AE4" modified="2013-05-01" version="1">MAAPSYARATASSTSKASPKSSRTTRNLEWVKPTPSPSSKRLTESPNNFTPTSQEKKKALKRPSTLTSHQKDNMIYKRDLYHITPKDSSKPCSLSLLPSELRTQIYTYILPSTYYISPSWPSFSKPKHHAPPALLHISRAIRIEAAYTYYTTTTFHFTVRNLDFSPVTRWLEDLAPQHRALLPRNHHGLEINVIPAVRSTFTYPPKGWLLDADIEHHWRACQPFGNIYTVRGEAHKIHFVVFCRLAEWWRWCGVLHLKGEVKCNYAFEQSPFANPFGIPDFLDEVVLRAFLRHHGCVIGMSCVDKAWRRNRRAAAGMKGEGLRFLEALDKWYKDRWGEQESINEWDVNMEEAKKAIGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUH0</accession>
    <name>M2RUH0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_77410</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695328.1">
        <property type="nucleotide sequence ID" value="XM_007697138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUH0"/>
    <dbReference type="STRING" id="665912.M2RUH0"/>
    <dbReference type="GeneID" id="19140611"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_77410"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_59_3_1"/>
    <dbReference type="OMA" id="TEWHPIS"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="315"/>
        </location>
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            <begin position="1"/>
            <end position="58"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="492"/>
            <end position="553"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="12"/>
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            <begin position="48"/>
            <end position="57"/>
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    </feature>
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            <begin position="458"/>
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        <location>
            <position position="93"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
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        <property type="nucleotide sequence ID" value="XM_007706658.1"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2RW86</accession>
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        <recommendedName>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59328.1"/>
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    <dbReference type="GeneID" id="19134273"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_203738"/>
    <dbReference type="eggNOG" id="ENOG502SQ3E">
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    <dbReference type="HOGENOM" id="CLU_011409_12_2_1"/>
    <dbReference type="OMA" id="QMEYLLR"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
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    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
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        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
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    <dbReference type="InterPro" id="IPR036864">
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="568" mass="63581" checksum="1ED11988E1798B26" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2RWC7</accession>
    <name>M2RWC7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_257889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705099.1">
        <property type="nucleotide sequence ID" value="XM_007706909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RWC7"/>
    <dbReference type="GeneID" id="19135368"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_257889"/>
    <dbReference type="HOGENOM" id="CLU_1434338_0_0_1"/>
    <dbReference type="OMA" id="QFEYSIA"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024498" evidence="1">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="189" mass="20080" checksum="85FDBF14C6BF2916" modified="2013-05-01" version="1">MFSKTILLMALNAGLTLAGNAILTNRCSYDIWVSSVGGSHQTPCTLVPARTQYTEVLYNTGTSLKVSSTDSIKNGEHTQFEYSIADGKIWYDISFVNCAKGNSASACPGHAEGLSMRGTDNQCSAADCAAGDYCPSQAYYVDTPLIKLGIKEPVFDCPTTDVDIHMTVCSGEGSLKRSVAGRVAIDLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2RY42</accession>
    <name>M2RY42_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_99727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704245.1">
        <property type="nucleotide sequence ID" value="XM_007706055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RY42"/>
    <dbReference type="STRING" id="665912.M2RY42"/>
    <dbReference type="GeneID" id="19141871"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99727"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="OMA" id="SHSCAVA"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD59983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="486" mass="52716" checksum="EDA56EA91C99BF56" modified="2013-05-01" version="1">MQGATIQAPGLSTFLKSLKSTPVDASVEHFTSLLKRRQIRNSRPCAIATTALLLRVVGEFKGRDAAKLIERIKQVGRRLTSAQPREVVVGNIVRRVLGLVREVVDEHADGQTPTGSDRGNATPHAHASHDSLHRPALQSSISTFSPLRHAVAEPMPTGGFTDNASDASEPSRRPPLLTSHTSYAPASAAPLVHSLFGLFSQPADTPSATSTPTGQASPTGRSNLTALNLERLAGMERGQNLDLKGEVMEGIRELQDELETSDKQIAEVALEHIHANEIILTHTASTTVQKFLLFAARKRKFTVVHAETYPDDHTATHGILLTGKKREANPDDDEDDDKWKPLTDAGIQVYVIPDSHVFAIMSRVNKVILATHTVLANGGLVAAAGAHMIAKAAKEHQTPVVVLSGVYKLSPVYPFDIDELIEYGDAGSVVPFDDGEFVDKVDVENPLYDYVPADLVDLYITNLGGHAPSYLYRIVADHYRSEDITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZN6</accession>
    <name>M2RZN6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_163837</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703841.1">
        <property type="nucleotide sequence ID" value="XM_007705651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZN6"/>
    <dbReference type="STRING" id="665912.M2RZN6"/>
    <dbReference type="GeneID" id="19132272"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163837"/>
    <dbReference type="eggNOG" id="KOG3459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_2_1_1"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="35"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="117" mass="13415" checksum="778E1AE1C5974685" modified="2013-05-01" version="1">MVDAKIQELLSKPRSELTEYEVAQVEEHELTTGPLSILQTAVRSRTQVLISCRNNRKILARVKAFDRHCNMVLENAKEMWTETPRLANGSYGRKVNKDRFISKLFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2S013</accession>
    <name>M2S013_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_244641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703902.1">
        <property type="nucleotide sequence ID" value="XM_007705712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S013"/>
    <dbReference type="GeneID" id="19135088"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_244641"/>
    <dbReference type="eggNOG" id="ENOG502SRHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120129_0_0_1"/>
    <dbReference type="OMA" id="REQTRIP"/>
    <dbReference type="OrthoDB" id="5405107at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="181" mass="19246" checksum="6B6B72EB9580BED7" modified="2013-05-01" version="1">MLSSIIPLPTLLLTLYTLSLIIPTISRLRRYESASKTAAQYSNTAAKKLHKTQVTQASGVVATVVSLISSLYLLSSPDAALLSPPVIAVLNTIICALAYAHMAGFWNEREQTRIPLVKDFNEAIRGSEKVVLLLGTLGLGWGVAAGVWVVGMGEGLMGLAVWVVAVGARVWGIAGEMGWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2S565</accession>
    <name>M2S565_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_38265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ND90Pr / ATCC 201652</strain>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
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        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
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    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="508" mass="59076" checksum="874112FAC4CAF91C" modified="2013-05-01" version="1">MGLLQDMTQRLPTTKESLDRFDDLSRRAEKTTPRLSFFRRRVRLKGSSSVSIPLGLVLLFPCLVIIIIIILFVRSPDSQGIMNMPAGTPPSIRKISEKYDKPFAVGCLEPQVNGPRANAAFVVLARNKELDGVLQSIKSIERHFNRWFHYPYVFLNDGDFNETFREVVLKHVSAPVEWGKIPPEQWGFPDWVDPDVAKEGIAKQGDNAIMYGGMESYHHMCRFYSGKFYQHELLAKYDWYWRLEPEIKYFCDITYDPFIHMIRNKKTYGFTIAVKELRETVPNIWRYASAYKRNNNLTSKGMWEMFVEKPKPEDEDTQKNEPKPKKAFFPQDIMDSEFGSDALPEIHPENMEGESYNMCHFWSNFEIANLNWFRSQEYNDFFELMDRSGGFWMERWGDAPIHSLAVGALLGPEDIHYFRDFGYRHTTIQHCPANAPARQLPRDPYLELTTENEKERIEEDKYWATPDPVKENGVGCRCKCDTDIVEVEGKEGSCFPEWVEVAGGWASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGZ2</accession>
    <name>M2SGZ2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_158578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="3"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697964.1">
        <property type="nucleotide sequence ID" value="XM_007699774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SGZ2"/>
    <dbReference type="STRING" id="665912.M2SGZ2"/>
    <dbReference type="GeneID" id="19131905"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_158578"/>
    <dbReference type="eggNOG" id="ENOG502QQFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031603_2_0_1"/>
    <dbReference type="OMA" id="TPQPFRM"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000299">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF40">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025411" description="mannan endo-1,4-beta-mannosidase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="34"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="496" mass="55890" checksum="AEB6C65923A49DEE" modified="2013-05-01" version="1">MKASLQLLLASLAAGSVLPRNEQSSHESAIADDDFVYVEGTRLYDKDGLHYLTGMNYWACMNLAASDSAGGNYSRLVTELDQMAAHGVNHLRIMAGSEGAPTPQPFRMSPALQEAPGEYNEEIFKGLDICLAEMSKRGMRATMTLNNQWQWSGGFAQYVSWATNNTKIPYPPSWNLTASPQREVPGTGWGNYTEQGVDAASYNDFVAYANLIYNNTQAEQWYMDHIKTVMSRRNTVTGLLYTEDPAIMTWQLANEPQPSDILGYTGPYNLFSVPNPNDLLFPWVDRISRYIHSISPRQLISVGLESKQGEYYFKRVHDFPTVSYATTHCWVQNWGIYDMYGESDANLATSQQFARDFMKNSSRWALDIGKPVFLEEFGMARDNWVNKNKEYPYLSSAPTTHKDAYFTTIIGTVMDEFRNGGAYVGTCPWAYSGVYRPETQQANEFGMVWAGDPPHESPGWYGLYDDDHAMDIVKAQQEMIVQWIAENGNGTSHQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SH44</accession>
    <name>M2SH44_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_234960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703002.1">
        <property type="nucleotide sequence ID" value="XM_007704812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SH44"/>
    <dbReference type="GeneID" id="19134856"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_234960"/>
    <dbReference type="eggNOG" id="ENOG502S8CY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004543_2_0_1"/>
    <dbReference type="OMA" id="TSKFGTW"/>
    <dbReference type="OrthoDB" id="5346713at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="978"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1129" mass="120817" checksum="1CD5EACA6AC6A2C9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHK5</accession>
    <name>M2SHK5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_85344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698116.1">
        <property type="nucleotide sequence ID" value="XM_007699926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SHK5"/>
    <dbReference type="GeneID" id="19141054"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85344"/>
    <dbReference type="eggNOG" id="ENOG502SKU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054245_0_0_1"/>
    <dbReference type="OMA" id="VSDHRLK"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="292" mass="31356" checksum="DAC5F670546DB149" modified="2013-05-01" version="1">MTVDDPSDTPAPFSYDAGDAGSRSRLAVPSRQVAYASQPSAPARRAFFDPWNSSSTGHQRAENWLSGSTLWRTSRNLKLGEQFKGGRHGGKRIADTVGAGSDDSANVGLHGLRTGGQKSLAEVWAAGKSCTQPSKNKEPKTESEFEPETYSESNICEDSSVPPEKQLFAGLCFYLNGSTAPLVSDHKLKQILATHGATHSTTLGRRIVTHVILGTINARGGAGGGLAATKLQKEIVKTGGKTVKFINADWVLDSIKANRRLPESRYSPLKFAPKSQSTIFSTMRARTPPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHW6</accession>
    <name>M2SHW6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 19">Pyruvate carboxylase</fullName>
            <ecNumber evidence="6 19">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">COCSADRAFT_38783</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="6 19"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702113.1">
        <property type="nucleotide sequence ID" value="XM_007703923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SHW6"/>
    <dbReference type="STRING" id="665912.M2SHW6"/>
    <dbReference type="GeneID" id="19139340"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38783"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_0_1_1"/>
    <dbReference type="OMA" id="AEACICY"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000002">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
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        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
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        <location>
            <begin position="135"/>
            <end position="242"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="270"/>
        </location>
    </feature>
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        <location>
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            <end position="502"/>
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    </feature>
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            <end position="759"/>
        </location>
    </feature>
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            <end position="443"/>
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            <end position="474"/>
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    </feature>
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        <location>
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            <end position="739"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="759" mass="84432" checksum="F7B3284A46E56903" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNT0</accession>
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        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_41898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502SRG9">
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    <dbReference type="OMA" id="VRQICDM"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14308">
        <property type="entry name" value="UBA_Mud1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="471"/>
        </location>
    </feature>
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            <end position="57"/>
        </location>
    </feature>
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            <end position="101"/>
        </location>
    </feature>
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            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="493" mass="53959" checksum="F9BA4CCAECBAC759" modified="2013-05-01" version="1">MRFTPAEETEQTESPCRESPPHASLGAPVVAIQKSPGWPATQRSKCASSSQPNQNPSKNDCSSFEGHTADGEPVVSKTNSPLISMKTPTPRPESHTNDQAEAKISPRLHKSRAPPSSDDELSAIGLLQERYKPRPSRSRSLKVDTEEPIDYSVRPEKAAKLSKRRRTTADMRAANAITTPEKVRQICDMGFTPSTTARALRRNNGDIIQTVDWLVTNNIGHDELAPQSPPKPMPKPREEGEPEVVDVQTVQGIMRNLDEYRRDDCETAEHGQAAGPDADSSTTDLIDVNTVAETSNPNKRSETDQNMSPTKVQVVIPKKSPKAAVARAEDAINVSSKKSKRKRITLDQTESESFSLLVPVPAPVNEKKRGRGRPKKTPTTSDAIGPIVPREQEEKEGQPSGSLQPIEQKLATEKIDPSSDITPDEPQPVEPVISQDTERVKVPTKLDPAPTSETPEKSAKPITPSSMTKGKVPYRVGLSKRARIAPLLRTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>M2SPS0_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">Cnl2/NKP2 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_171371</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701949.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SPS0"/>
    <dbReference type="GeneID" id="19132740"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_171371"/>
    <dbReference type="eggNOG" id="ENOG502S7X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077446_2_0_1"/>
    <dbReference type="OMA" id="REQDMDR"/>
    <dbReference type="OrthoDB" id="2311687at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018565">
        <property type="entry name" value="Nkp2/Cnl2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09447">
        <property type="entry name" value="Cnl2_NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21796" checksum="F7E17F9462B5971F" modified="2013-05-01" version="1">MPSQEAKILCDFLLTPAPLRDFITLREFTDIFPRAHRANPAVQDIYRELQRLRDKDIELVRRDIADEVKRSKQLRREYARERRQVDDAIVAGLDPIALQMEQELSGEGRKKPHTLWTVHSDIEEACQSLEAQIAEIEQQNRDVLREVQDVVGALSDLRHGRFPVSTSGDSLGEEVTVALRQLETVCGKPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ60</accession>
    <name>M2SQ60_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_256655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705023.1">
        <property type="nucleotide sequence ID" value="XM_007706833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ60"/>
    <dbReference type="GeneID" id="19135340"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_256655"/>
    <dbReference type="HOGENOM" id="CLU_2775772_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="69" mass="7773" checksum="BF67DE78DAD03C6F" modified="2013-05-01" version="1">MKKRKKNKTKDSPSHDNSSTKQGLASRSIKVPDQLLQLTRKNNTLRCAPLSLLPSYTGNHLPIIYTLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQV4</accession>
    <name>M2SQV4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_203869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705184.1">
        <property type="nucleotide sequence ID" value="XM_007706994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQV4"/>
    <dbReference type="GeneID" id="19134279"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_203869"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="IPIDNAW"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="27768" checksum="F6A954FB813CB8B4" modified="2013-05-01" version="1">MSIASLQDKVAIITGCSSGIGLATTRLFLERGASVFGIDIGAQPQKLIEDFSTFIFYQSNLTDSQAVEHAVAKCIGKHDRIDVLVNCAGVSDGWSSADTIHEEEWERVMAINLTVPIRMMKAVLPAMKSQKKGAIVNVASKAGMSGASAGIAYTASKHGLVGATKNVAWRFHNEGIRCNGVLPGSVATNIASSVQMEHFDSAGFNAFFPIVQLHVSKDNEGTPVPYISVDHVARGIAFLASDESQMINGAMVPIDNAWSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR43</accession>
    <name>M2SR43_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_151909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704594.1">
        <property type="nucleotide sequence ID" value="XM_007706404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR43"/>
    <dbReference type="STRING" id="665912.M2SR43"/>
    <dbReference type="GeneID" id="19131570"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_151909"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OMA" id="APCMHAG"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="479" mass="52251" checksum="F16748DC8EB7D71C" modified="2013-05-01" version="1">MSPGKVSTLDFEKFYNIVDGQQRGSDQIHHGINPATGQELWDVPVASEKDLNDAVASAKKAFPAWRDTAVEERKALLAKVMESFQQHSDEFINLLCKESGKPRKWSAFEVGSIAGFISHHLTLNLPTEKLEDDEKTVYTEYSPLGVCGAICPWNFPLILMVGKVAPALLTGNCMIVKPSPFTPYTALKFVEVAQDILPPGVLQVVGGNNELGVQMCLHPGIAKISFTGSTATGKKVMETCAKTLKRVTLELGGNDASIVLPDVDIKKVAPEVVMGAFQNSGQVCVATKRIYIHESIYKEFLQEMVNFTKQIKVGSPDDGDNMLGPVQNQMQYERVKGFFEDSKSKGYNFAVGEPDVAASKGFFITPTIIDNPPNDSRIIQEEPFGPIVPTQPWSDLEEVIARANDTNTGLGACVWGKDVEKASKIARRLEAGSVFVNSFEKPTPQALFGGHKESGIGGEWGTTGLLAYCNPHVIHVYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRI0</accession>
    <name>M2SRI0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_164955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705126.1">
        <property type="nucleotide sequence ID" value="XM_007706936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRI0"/>
    <dbReference type="GeneID" id="19132347"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164955"/>
    <dbReference type="HOGENOM" id="CLU_1740374_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="150" mass="16964" checksum="2A027E4D3FD3E8EE" modified="2013-05-01" version="1">MGVIVGPERLHMPQDHDSFYTVEELTSLLSPVRQQGPHDWVGLYGELHKIFDLTLEGAHIVIFPSWGIERKDCFCCCGAAVPKCSGNVDMRVDVQQGEDLLCIPQQLWPLNTDDHIGIERDIAVDLILYIFQSRPKTAELDTEFPYKANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRV9</accession>
    <name>M2SRV9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mpv17/PMP22 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_40738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704473.1">
        <property type="nucleotide sequence ID" value="XM_007706283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRV9"/>
    <dbReference type="STRING" id="665912.M2SRV9"/>
    <dbReference type="GeneID" id="19139820"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40738"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_8_1_1"/>
    <dbReference type="OMA" id="WYQSKLA"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21429" checksum="8DB1DE4ED7E52D54" modified="2013-05-01" version="1">MAFRWYQSKLRTSPLLTQSITTAVLFATGDTMAQQGVERRGLDKHDLMRTGRMAAYGGCIFGPAATTWFGFLVRRVNLPSKNGTIVARVACDQFLFAPVNMTVFLSSMAYMEGNSPTQRLKDAFVPGYQKNLMIWPWVQFANFKYVPAEMRVLVVNIISLGWNCYLSYLNSAGGKKPALPVGETKEGGQLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS53</accession>
    <name>M2SS53_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_100424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_007706012.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10265068at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD59921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36700" checksum="ACEB26731BD437E2" modified="2013-05-01" version="1">MEVAAAMVSFVGLVGTVAQGQKFLYDFTTNMKDCPKDIHEMKTDIELVEALITQVVQQSNERDGRLRESAVLARAIGHAQESVKDLKKELAMYPSNGKHRRFRFATKLSQTKKLRASLDRSKTIMLDLKTQLHSDLLYEIRDMNQEVLRSIENTSGNLETHDRNSHKVTQKSMVQEETTDNSRGKAEALVPPASDTSSEGLTNVEIAAKNLEHTTGLLMETGISSSPALLPSTPALSREVSDISVISSSQETTASSISSSQSIPPSVSQDAQKANIASKHPLLQFKDNQFQFLVAIIFTQRATKQKNLACQHVVTTDTTLLEYMEHLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSW9</accession>
    <name>M2SSW9_COCSN</name>
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        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
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            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
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        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">COCSADRAFT_114081</name>
    </gene>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007700358.1"/>
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    <dbReference type="STRING" id="665912.M2SSW9"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000005">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="338"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="813"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="582"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="705"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="813"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="947"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1044"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD65385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1082" mass="121449" checksum="9A4977709DC41857" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST46</accession>
    <name>M2ST46_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_70880</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="665912.M2ST46"/>
    <dbReference type="GeneID" id="19140471"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_70880"/>
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    <dbReference type="OrthoDB" id="20872at2759"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="26"/>
            <end position="114"/>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="244" mass="27866" checksum="7AE502B87FC79C0F" modified="2013-05-01" version="1" fragment="single">MLLLFTEIDRGFGWTDDLVGGNIPPYAILSHTWQGEEVTLADLKDSPNGGRDKKGYKKLLFCAQQAALDGLEYFWVDSCCIDRSNSVALEDAINSLFYCYRNAAKCYIYLSDISTPDWEETSKKSDCRWQSAFRKSKWFARSWTLQELLAPRSAEFFSCEGQKLGDKNTLRQTLHEITGIATQALEGRPLAHFSVRERLLWAANRGATLEEDQVYSLLGIFGIKMTMMYGEGSWNACLRFWDEI</sequence>
</entry>
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            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">COCSADRAFT_180251</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
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            <begin position="318"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="815" mass="92095" checksum="C27A21A6FFFE7CE6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU46</accession>
    <name>M2SU46_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_98899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SU46"/>
    <dbReference type="STRING" id="665912.M2SU46"/>
    <dbReference type="MEROPS" id="M20.005"/>
    <dbReference type="GeneID" id="19141828"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_98899"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_3_0_1"/>
    <dbReference type="OMA" id="CNVKFMI"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="214"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703924.1">
        <property type="nucleotide sequence ID" value="XM_007705734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUY9"/>
    <dbReference type="GeneID" id="19132280"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163931"/>
    <dbReference type="eggNOG" id="ENOG502RY3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_3_1"/>
    <dbReference type="OMA" id="LSWVKID"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026006" evidence="5">
        <location>
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            <end position="266"/>
        </location>
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    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="6">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="266" mass="28926" checksum="472D127C87F619B5" modified="2013-05-01" version="1">MMGLLTTVTSSLLLAGVSAHARIEKITTSAGLVYNGWDPVSSETLTPPRPLAAWSAVNMGNIFVSPSHFNTSNITCHDNAIPGALHVNTTAGDTLQLKWNEWPVSHVGAVMTYIAKCNTTCSKANKNTLSWVKIDELAWLNSTGWDTLELGGTWATDVLIANNFTWEVKIPEVLAAGYYTLRHELLALHVAEQLDGAQAYPQCINLRVDGETGAEAKHLEGGVLGTNLYRPTDAGILVDVHKKLTGYDTPGPKLWEYASPLRQPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703226.1">
        <property type="nucleotide sequence ID" value="XM_007705036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVI7"/>
    <dbReference type="GeneID" id="19137683"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_344945"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="OMA" id="SIYGYAC"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
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    </dbReference>
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        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025398" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60847.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="531" mass="57194" checksum="266B742A41C65242" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVL7</accession>
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        <recommendedName>
            <fullName evidence="3">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_197839</name>
    </gene>
    <organism evidence="4 5">
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        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697869.1">
        <property type="nucleotide sequence ID" value="XM_007699679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVL7"/>
    <dbReference type="STRING" id="665912.M2SVL7"/>
    <dbReference type="GeneID" id="19134041"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_197839"/>
    <dbReference type="eggNOG" id="ENOG502SKET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055874_0_0_1"/>
    <dbReference type="OMA" id="MADGPKT"/>
    <dbReference type="OrthoDB" id="187522at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264:SF1">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026020" description="Inosine/uridine-preferring nucleoside hydrolase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD66355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="340" mass="37106" checksum="F20249EF4DEAEB74" modified="2013-05-01" version="1">MFVSLKWIYALAILSLLSFVESANQPTKEFIVDTDLFDAIDDTAALLLASTLPNTKLLAVNVNVNSAYSALAASAIVNYYGYSSIPIGLQRPYTNVTSSEPFGKEYASRVAIRWSGGSVPWFEVNKTLDPVELYRKTLGEAKNGSITIVSLGFMGSLSGLLNSTADKYSPLDGYGLVKAKVKELVVMGGGYLAEGSLDQEYNFAIQEAPHVVNTWPNLVPMTFIGAELGVQVLTGARLTTCGPSGDPVRTSFEWWGGANVSQYSWDHLAMAYAGRGLGNWFEYANANGYNYVYPNGTNIWVEDERITNQHYLKLKTSNETVAKGLEDLLLRGAWANAQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVU2</accession>
    <name>M2SVU2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_163375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703321.1">
        <property type="nucleotide sequence ID" value="XM_007705131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVU2"/>
    <dbReference type="GeneID" id="19132238"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163375"/>
    <dbReference type="eggNOG" id="ENOG502RACY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043852_0_0_1"/>
    <dbReference type="OMA" id="VICTDDM"/>
    <dbReference type="OrthoDB" id="3767798at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="350" mass="40796" checksum="1BC3DF06F3F8BED9" modified="2013-05-01" version="1">MAPKDLLRSRPCGVSTVLILILGSLIFRWATLRDLSEYDPFVPILQGEIVARVPGLGDAYGMANNHLDSSLDLEYWRERMRGTITIDSDLESGSGDSMDTEFQQALRESRDDYFDTVDGELKQFIHIPVGAPPHLRVLPQQSLWNRPYFRDPRRGLNHFDYIDNTWVLRHPALHHINPSDFDFAAEYLESDGFGIRLPLDPDSSSSEDYSTVLEQCHAAWNVADSLDMHDLMEHVVDKLEAIKPGRDEMMVFACRIFGKRGGVDLPGHYRLKEYLAKFIAENWWEYIRELGEWFVKRLERLPELERDVCKKRLEVLNERLDKEDGEEEEEEEEEEEEEKEEQCEEDMEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SW29</accession>
    <name>M2SW29_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_85248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697976.1">
        <property type="nucleotide sequence ID" value="XM_007699786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SW29"/>
    <dbReference type="STRING" id="665912.M2SW29"/>
    <dbReference type="GeneID" id="19141049"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85248"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017900_0_0_1"/>
    <dbReference type="OMA" id="HSPQMED"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
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        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="382"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="104"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="568" mass="62939" checksum="F47303CAB8793A0D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWD1</accession>
    <name>M2SWD1_COCSN</name>
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        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_113170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWD1"/>
    <dbReference type="GeneID" id="19130209"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_113170"/>
    <dbReference type="eggNOG" id="ENOG502QS7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010399_2_0_1"/>
    <dbReference type="OMA" id="VEWMCVP"/>
    <dbReference type="OrthoDB" id="406733at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="2">
        <location>
            <begin position="349"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD66590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="738" mass="83957" checksum="13132523026ABADD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWH5</accession>
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        <recommendedName>
            <fullName evidence="6">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_96978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD61336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_007702712.1">
        <property type="nucleotide sequence ID" value="XM_007704522.1"/>
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    <dbReference type="STRING" id="665912.M2SWH5"/>
    <dbReference type="GeneID" id="19141713"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_96978"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="OMA" id="PMWLGDV"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001614">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="136"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
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        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
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            <begin position="375"/>
            <end position="414"/>
        </location>
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        <location>
            <begin position="415"/>
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    </feature>
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            <begin position="257"/>
            <end position="277"/>
        </location>
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        <location>
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    </feature>
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        </location>
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        </location>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD61336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1241" mass="135096" checksum="313E7A4AF1BDDFF2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWX5</accession>
    <name>M2SWX5_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_169697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD66810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700012.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SWX5"/>
    <dbReference type="GeneID" id="19132643"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_169697"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028907_0_0_1"/>
    <dbReference type="OMA" id="RPLNMAF"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="Mo25"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="607" mass="68555" checksum="0C6C125573579652" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXU5</accession>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
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        <name evidence="6" type="ORF">COCSADRAFT_182975</name>
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    <organism evidence="6 7">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702181.1">
        <property type="nucleotide sequence ID" value="XM_007703991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXU5"/>
    <dbReference type="GeneID" id="19133386"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182975"/>
    <dbReference type="eggNOG" id="ENOG502SJ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_2_1"/>
    <dbReference type="OMA" id="DIDMMCL"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="93"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="207"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="440" mass="49279" checksum="200938ECF853FA7A" modified="2013-05-01" version="1">MTSTTTIKICSNGDHMDVYEELGNNLLQALLTYSQRLRQENLSMLGLFPNSSEISKSLSEEGRREKGRVIELAQEILATTIDPTTSLLLDSLQFHFCSCLKVVLDLGVGHQMRKDEQKSLEQLAKAVGADQALLTRIMRVVMTKYVFAEPQPGVYCHTSISWEMQEPAMHHLLLHRLDEGFRSASREPDALRLNNYRDPLPDDMSGFNLAFDCSENFWEFIANTDIKRGHRFNQAMKAVTINSLAEIPSLFPFASLAKDGGLIVDIGGGLGQVSRHILSCNPGAGLRCVVQDQHAFAGSLPKRPDEVDVHEKENEALALEFQQHNFFDPQPVRGAAAYFFRHIFHDWSDTACLKILRQIIPAMHPQHSRILICDQIVGDKSPSVSSVLYDVDMMTLFGGKERSLLQFLDLIKAADQRFYIDDVKRSAGSATTIIVVKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY79</accession>
    <name>M2SY79_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702093.1">
        <property type="nucleotide sequence ID" value="XM_007703903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY79"/>
    <dbReference type="GeneID" id="19139320"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38705"/>
    <dbReference type="eggNOG" id="ENOG502QW0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_0_2_1"/>
    <dbReference type="OMA" id="SNAWRPL"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="34"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="357" mass="40119" checksum="987D68BEC42FF665" modified="2013-05-01" version="1">MSGLDYSSLVSIPISYATCSLGSPSNPPPLLDRLQAISDAGFSALELSFPDILSYGQTLLGHEVQPSNYDELCTVAAEIKKECDQRNLGIMMLQPFANYEGWPEDSPGRKDAMDRARGWIRIMQACGTDMLQVGSTDTPLEKLERSKMVSDLQVLCDMLNEHSFRLAYENWCWSTHAPDWKDVWSIVQQVDRPNIGLCLDTFQTAGGEWGDPRTASGMREDVSKNELEKRFQKSLEELSTSIPKEKIYLLQISDAYKVPQPMNAERDESGLLPRGRWSHDFRPLPYNGGYLPVVDVARAVLKTGFRGWFSYEVFDGGSDGKKTDVDIVTYARAAKNVQERLLQECAGQKVHEEMATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZF1</accession>
    <name>M2SZF1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_95267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702453.1">
        <property type="nucleotide sequence ID" value="XM_007704263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZF1"/>
    <dbReference type="STRING" id="665912.M2SZF1"/>
    <dbReference type="GeneID" id="19141605"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95267"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_2_0_1"/>
    <dbReference type="OMA" id="HCRLAQS"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD62152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="745" mass="80214" checksum="70D30EB47E1B9316" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZW1</accession>
    <name>M2SZW1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_201129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701840.1">
        <property type="nucleotide sequence ID" value="XM_007703650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZW1"/>
    <dbReference type="STRING" id="665912.M2SZW1"/>
    <dbReference type="GeneID" id="19134178"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_201129"/>
    <dbReference type="eggNOG" id="ENOG502SMRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_4_2_1"/>
    <dbReference type="OMA" id="LMRNEHI"/>
    <dbReference type="OrthoDB" id="5271017at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF3">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025475" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="24"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD62481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="220" mass="23394" checksum="B3ABECBA392EB89F" modified="2013-05-01" version="1">MKVSAVILAVASLASAHYTLPSINGGVPWAHVRQAKNWQDNGFVGDVTSNDIRCNQLKPGTATMTVAAGSSVKVSVNPNAYHPGPFQSYLAKVPAGADINTWDPTGAVWFRIYAEQPKFGNQLTWLAAGTYDIKIPQCIAPGKYLMRNEHIAIHTAGQRGGAQFYLSCAQIEVTGGGSTSPRNLVAFPGAYSATDPGILININYPIPTSYVNPGPPTFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0Q5</accession>
    <name>M2T0Q5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_33076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695446.1">
        <property type="nucleotide sequence ID" value="XM_007697256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0Q5"/>
    <dbReference type="GeneID" id="19137027"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33076"/>
    <dbReference type="eggNOG" id="ENOG502STNI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120569_1_1_1"/>
    <dbReference type="OMA" id="TYFEPIE"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="104" mass="11916" checksum="1B3A716B145B0C5A" modified="2013-05-01" version="1">MPKIVRLTLFKIGDKDTIQEVIGLYSTLAQDATKDGKQYIQLAQASAPYDDHRSQGYNLMARCVFDSLTDMEYFDQADEVHAGIKKQLLHRFEAKPLIIYSDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0R8</accession>
    <name>M2T0R8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_334286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701147.1">
        <property type="nucleotide sequence ID" value="XM_007702957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0R8"/>
    <dbReference type="GeneID" id="19137176"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_334286"/>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="OMA" id="TNFRSTH"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33264" checksum="80DCD59E50A48BCB" modified="2013-05-01" version="1">MDTRYLHSGLPGLTAHPTMVCHRESYPALEAVQRSAAGKYVLITNASHGIGRAIAVSWARAKAAGIAISSLNAEDLEFVAEEIRRINHNIPIVAMTCDTTSSFDVNNFFSATKDILGRLDVAIANVGTTHLDYLDITDDNDLWWADVMTNFRSTHLTAHQYLRTFGPSPIGTFISITSGANFCVGAGVSSHEFAQQIDHRLLEFLAFEYPMMKAFSLNSVPIHVRRTRLIHGHPEICNPELVGLFSVWLGGGRADLLRGNSLRAEWDIGELERNMWQALEKDTLKQKISSGCLRLAMRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0Y7</accession>
    <name>M2T0Y7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_121581</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701988.1">
        <property type="nucleotide sequence ID" value="XM_007703798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0Y7"/>
    <dbReference type="STRING" id="665912.M2T0Y7"/>
    <dbReference type="GeneID" id="19130495"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_121581"/>
    <dbReference type="eggNOG" id="KOG2263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_1"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071265">
        <property type="term" value="P:L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="18">
        <location>
            <begin position="4"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="17">
        <location>
            <begin position="435"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="382"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="524"/>
            <end position="525"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="662"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMD62672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="766" mass="86494" checksum="177722B869D6F708" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2T137</accession>
    <name>M2T137_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_187237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="188" mass="21568" checksum="9BE5935F9CB577B4" modified="2013-05-01" version="1">MTEALLLRTFPLATFMIKVRYYGVGSVAFKNIRNSILDTLIASTLDGRESVYQKKTPVVHECFLSWCVRTIKSLYDLSEYHKNPLSFFYNSTNGPNTWISRGIPEHQGGGTWIEYKKNITITTLVIDPTHTNYSIEYGSSNVTAQNFMTIFGEFFPSPYSIDNISTIPILQYKRLLLRHRPLTTRPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1D3</accession>
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        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">COCSADRAFT_119937</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007703092.1"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_119937"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="NAYAVYT"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="351"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD63011.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="555" mass="61204" checksum="5BF8941AFFC5007C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2T223</accession>
    <name>M2T223_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_92985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701461.1">
        <property type="nucleotide sequence ID" value="XM_007703271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T223"/>
    <dbReference type="STRING" id="665912.M2T223"/>
    <dbReference type="GeneID" id="19141478"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92985"/>
    <dbReference type="eggNOG" id="ENOG502QVAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017851_2_0_1"/>
    <dbReference type="OMA" id="KKVHTEQ"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="247"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD63251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="641" mass="71284" checksum="D35AC736820818F9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2M8</accession>
    <name>M2T2M8_COCSN</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_145636</name>
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    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007703286.1"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_145636"/>
    <dbReference type="eggNOG" id="ENOG502S3YY">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237144_0_0_1"/>
    <dbReference type="OMA" id="TWDTNSV"/>
    <dbReference type="OrthoDB" id="6365728at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1497"/>
            <end position="1525"/>
        </location>
    </feature>
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        <location>
            <begin position="1697"/>
            <end position="1802"/>
        </location>
    </feature>
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        <location>
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            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="659"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="746"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
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            <end position="447"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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            <end position="1321"/>
        </location>
    </feature>
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        </location>
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            <end position="1423"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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    </feature>
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        <location>
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            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1793"/>
            <end position="1802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD63282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1831" mass="206316" checksum="DEA9B70562BD0759" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2W3</accession>
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        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_33674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695598.1">
        <property type="nucleotide sequence ID" value="XM_007697408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2W3"/>
    <dbReference type="STRING" id="665912.M2T2W3"/>
    <dbReference type="GeneID" id="19137257"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33674"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034860_0_0_1"/>
    <dbReference type="OMA" id="CRDREVW"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="381" mass="44177" checksum="EBA7D31AA6F6C1A5" modified="2013-05-01" version="1">MRRRRSDELPRLEKKLAWPSFRMRRQYVYYIIGFVFACWVLYPTHKPVPETVGVVKINWSNYAYSVYATDSASLCHAVMVLDALGRFGSKADRVLFYPEHWDTTVESSRDRDSQLLNLARDVYKAKLYPVKPLQVAGRTETEWLWDETVTKLMAFSLEYYDRVISLDSDITLLSPLDELFLLPPTPIAMPRAYWTDSKPWPLSTKLMVIQPNAKQLEKFKILMEGGGDSMLVRMHRYDMEILNERYEESALVLPHRPYALRTAEFRKHEHADYLGDADEKWDAEKVYKEAKVIHFSDHPLPPPWFTWPGGSVSEMQPDCRGNGEGSCAERRIWTGLYQDFQNRRRDVCKLLSVPAAPWALLKQQAGFNTTSTEHVAPQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2T405</accession>
    <name>M2T405_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_90858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700773.1">
        <property type="nucleotide sequence ID" value="XM_007702583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T405"/>
    <dbReference type="STRING" id="665912.M2T405"/>
    <dbReference type="GeneID" id="19141371"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90858"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_19_1_1"/>
    <dbReference type="OMA" id="YARPNID"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="422"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD63747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="594" mass="69041" checksum="179990C19929E48D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4X8</accession>
    <name>M2T4X8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_36622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="ADH-like_N"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0521">NADP</keyword>
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    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="10"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="343" mass="37206" checksum="97342BF53FEAF20F" modified="2013-05-01" version="1">MHAIAVTQYGPISNIKAINLPPSADPQGHDIPVRVKACSVNPVDTKVRAGTYDDYPDYYDRTPSLPQILGFDGAGIVESVGSEVAHFKPGDEVYYSGSPIRQGSNAKFQLVDSRAVALKPKSLDWGQAAAMPLTWITAYEALVERMEIQRGEKAGILIINGAGGVGSVASQIARHVLDLPVVVTTASRDETVKFSKDVGGATHTINHHKDISAEIEKLKLDVPIKYVFITHTPTSGYLAPAAKICAPFGKVCSIVQDKEMPMYATEFMAKSLTFVWALLGTKPYYGVDVESHGRILEDLARMLDEGTVKCHCMQKLKLDEEGVRKAHEIIEGGKAVGKVALEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
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    <name>M2T5B9_COCSN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="6 7">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5B9"/>
    <dbReference type="SMR" id="M2T5B9"/>
    <dbReference type="STRING" id="665912.M2T5B9"/>
    <dbReference type="GeneID" id="19130356"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_117287"/>
    <dbReference type="eggNOG" id="ENOG502S09W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377890_0_0_1"/>
    <dbReference type="OMA" id="CGAANWC"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_1"/>
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    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47849">
        <property type="entry name" value="CHITIN-BINDING LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47849:SF8">
        <property type="entry name" value="LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026430" evidence="4">
        <location>
            <begin position="18"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
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            <end position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
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            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD64192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="198" mass="20172" checksum="B17D779626E52439" modified="2013-05-01" version="1">MRFSTFALLSLVSGVLAGNCGPQNGNAKCASGECCSQYGWCGTTVDHCDAKTCIKDFSGASSKCNSKSPAQTFPDGVPEIDVCGHAQGGVSCPGAGANGYFYRCCSSAGHCGPKNDLQDQNLYCGTGCQAGFGKCDNQKAPGEPAGEKGVSQAGETCGPIVNKKCASGLCCSGSNFCGTGEDFCGAANWCQSKWGRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T602</accession>
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        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_140624</name>
    </gene>
    <organism evidence="11 12">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699248.1">
        <property type="nucleotide sequence ID" value="XM_007701058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T602"/>
    <dbReference type="STRING" id="665912.M2T602"/>
    <dbReference type="GeneID" id="19131172"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_140624"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OMA" id="GTWTHIT"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="69"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD64631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="451" mass="49940" checksum="6B0F20D351FF325F" modified="2013-05-01" version="1">MPASSTSSPSCPSPSSSNTITTPQTRLSQISSHIDPMAATAFDANVVPQAPEDPLFGLMAAFRRDEHPNKVDLGIGAYRDDNAKPWILPVVKMAEERLRSDPNLNHEYLPIAGLPEFTTASQKLVLGGDSPAIKDKRVTSLQTISGTGAVHLGALFLAKFYKPQTERTVYFSDPTWANHFQIFSNVGIQYKTYPYFSKDTKGLNFDGMISAIQGAPEGSIIVLHACAHNPTGVDPTQDQWKKIADVIRSKKHFPFFDTAYQGFASGDLATDGWAIRYFVEQGFEMCIAQSYAKNFGLYGERAGCFHFITSPSSDAESTITRIASQLAILQRSEISNPPAYGARIASTVLNDPTLFAEWEENLRTMSGRIKEMRKELRSKLEQMGTPGTWNHITDQIGMFSFTGLTEKQVLKIREDSHVYMTKNGRISMAGLNSHNIDYFAKAVDKVVRETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T654</accession>
    <name>M2T654_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_37044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699853.1">
        <property type="nucleotide sequence ID" value="XM_007701663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T654"/>
    <dbReference type="STRING" id="665912.M2T654"/>
    <dbReference type="GeneID" id="19138881"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37044"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043994_3_1_1"/>
    <dbReference type="OMA" id="EFKHWVV"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF85">
        <property type="entry name" value="INHIBITOR (TFS1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21605" checksum="0F3225A471D73E03" modified="2013-05-01" version="1">MTTTSLVDALKSANLLPSSIIPDYFTPTIDLSVKFPSGLAPERGSLARVSQIAEQPFISISSTSDSTSSASTYAFMMIDPDAPTPDDPKFAYWRHWVITSIPSTVSPAEDITSKGKTLTQYLAPGPKDESGPHRYLFLLFEEKEGETLERAEIGGEEFVERRSFRAEELVAKKGLKLVGVQWMRGVGDGWNGGKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6M3</accession>
    <name>M2T6M3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_140581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699222.1">
        <property type="nucleotide sequence ID" value="XM_007701032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6M3"/>
    <dbReference type="STRING" id="665912.M2T6M3"/>
    <dbReference type="GeneID" id="19131170"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_140581"/>
    <dbReference type="HOGENOM" id="CLU_2628744_0_0_1"/>
    <dbReference type="OMA" id="CINQIRQ"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="97" mass="11382" checksum="8510BCADF97CF34A" modified="2013-05-01" version="1">MALYPEYYTQHKVHGRKHTDHCINQIRQLIMCHGDITPIPTKYYAGYGGNYINSDQVHVCRDFESLLRWTTSRHNGREAVDPRYRNGTAKVLDFDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6T8</accession>
    <name>M2T6T8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_189745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699282.1">
        <property type="nucleotide sequence ID" value="XM_007701092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6T8"/>
    <dbReference type="GeneID" id="19133691"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_189745"/>
    <dbReference type="HOGENOM" id="CLU_1055782_0_0_1"/>
    <dbReference type="OrthoDB" id="10382524at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="235" mass="25848" checksum="D254E13B9BE42514" modified="2013-05-01" version="1">MSHMAYRFYQDHIEVSGCLCSISQRFCSTLMFFRQTILYEFDRSFWSDMILSVSAIAGITTAVFTVLIAGLGTVIYINRRRHQIRNKISFRAKTIAHSSPNTSRLQMLSSSAFITDPTKRTQDYHGRYPSLEKGPGPTVVKKGWSSMRSDFQSLKDTSNLPAIGSLDTCNNLTMPSARATVGADEGAPVPNTMTEPVSTGATTLAAARTMEIKRGPEDALKSRPSSLHQAVLDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7C0</accession>
    <name>M2T7C0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_36454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699171.1">
        <property type="nucleotide sequence ID" value="XM_007700981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7C0"/>
    <dbReference type="STRING" id="665912.M2T7C0"/>
    <dbReference type="GeneID" id="19138734"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36454"/>
    <dbReference type="eggNOG" id="KOG1467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_3_0_1"/>
    <dbReference type="OMA" id="MRDYVIC"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD65111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="502" mass="54407" checksum="2341BAA66FFA2CD9" modified="2013-05-01" version="1">MSEEPATMPAPVPAPDSTVSAAAPAPAEGAPAPANGDATDGPKKLSPAELKKQKQAEKQAKRAQAKAAGGAPNQQQGPPKDGQKQQKDSKQTSKDDKSKPLPVRRRPSQQNVPNSKEPEKKSKKDLSSKQTGLFFGHLYSQPKQQSLVGASKDVHPAVLALGLQYSSYTICGSTARMVAMLLVFKTVIEAYQTPPGNSLARHLTSHHLGPQIEFLKSCRPLSISMGNAIRWLKDVIIKIDPSTPENEAKRDLIEEIDIFIRERVTAADRLIRDLAATKIQAGDVILVYAASSIVEQTIIHAHESGIPFTVIVVDSKPLFEGKQLARKLANRGITVRYYLVTGASHAVKDATKVFLGAHAMMSNGRLYSRVGTALISMLAYSHSIPVIVLCQSVKFTEKVALDSIVGNEVAPAEEMLSEAERRALLPLKSRLPSSKNDDKTGSEDAPADTTDVLKWIEEAKNLHHLQVLYDVTPAQYINMVITEYGSLPPSSVPVVHRLSTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2T955</accession>
    <name>M2T955_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_87545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698834.1">
        <property type="nucleotide sequence ID" value="XM_007700644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T955"/>
    <dbReference type="STRING" id="665912.M2T955"/>
    <dbReference type="GeneID" id="19141189"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_87545"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_0_1"/>
    <dbReference type="OMA" id="QVKVERW"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="24"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD65781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="853" mass="91908" checksum="882365C324CACFA7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9N5</accession>
    <name>M2T9N5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Negative regulator of the PHO system</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_354868</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with a number of cyclins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698711.1">
        <property type="nucleotide sequence ID" value="XM_007700521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9N5"/>
    <dbReference type="STRING" id="665912.M2T9N5"/>
    <dbReference type="GeneID" id="19138320"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_354868"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OMA" id="NWQIFVP"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07836">
        <property type="entry name" value="STKc_Pho85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="135"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD65617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="454" mass="50707" checksum="A19BCA9CA12D3EA2" modified="2013-05-01" version="1">MAMQRRQLRGQVGALFSGCIFSVPSVPHQSPSRLLDRVVSLYSNTPAPDAARSSCSSSSLRIASQLTTASAILWDPKFTSRAPPGSLHPVHAGTLVPPHRTDSSISVRNLGDGDANGDTTPIVPTMDNRRHPSSFQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLDSEEGTPSTAIREISLMKELRHENIVLLHDVIHTENKLMLVFEFMDKDLKRYMDSRGDRGALDPATIKSFMYQLLKGIAFCHEARVLHRDLKPQNLLINNRGQLKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAEMYTGRPLFPGTTNEDQVQKIFRLMGTPSERSWPGISQLPEYKNNFPVYHTQDLRLILPQVDQVGLNLLNSMLQLRPEMRISAANALQHPWFNDLPQRQQEVAQMQAQAHAQAQQAQMGGGYQVPQNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2TD24</accession>
    <name>M2TD24_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_351903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696877.1">
        <property type="nucleotide sequence ID" value="XM_007698687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TD24"/>
    <dbReference type="STRING" id="665912.M2TD24"/>
    <dbReference type="GeneID" id="19138125"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_351903"/>
    <dbReference type="eggNOG" id="ENOG502SZ3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_990821_0_0_1"/>
    <dbReference type="OMA" id="TWAKFNT"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="282" mass="30770" checksum="332C681F5F7DE2A2" modified="2013-05-01" version="1">MITRQQHLDYTTALLKGRTLTTLMRATDHEAALLQTAQSAFLSPSALSHWGYERTHFILPPSSPLYHLQQSLGVDPSTNTAIGHSHLDSGVRNGVYVPVTWAKFNTVINAEAGMIAAVDNESPTQILLREGGGKEGGEKERGATLPELRYWSDVVFLQWQIVTVGNANLQFVFRLGITNGATLDVLQRILRKHGVVGREVVWTAREDKEAVAAILGTPNGSGVARLLLHHKRELGHKVVEEVRLVGWKGEGVGEPSLVFRIGNVYGEGDEGSQETIRGGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDG6</accession>
    <name>M2TDG6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_34117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696544.1">
        <property type="nucleotide sequence ID" value="XM_007698354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDG6"/>
    <dbReference type="STRING" id="665912.M2TDG6"/>
    <dbReference type="GeneID" id="19137459"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34117"/>
    <dbReference type="eggNOG" id="KOG0431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005723_0_0_1"/>
    <dbReference type="OMA" id="MLPDKHP"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="309"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="839"/>
        </location>
    </feature>
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            <dbReference type="PROSITE" id="PS50030"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="EMD67077.1"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_136207"/>
    <dbReference type="eggNOG" id="KOG1508">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAP-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00956">
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        <location>
            <begin position="9"/>
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        </location>
    </feature>
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            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="346" mass="39831" checksum="82105E636C7E1FE4" modified="2013-05-01" version="1">MEDHTHEEVSARFEELAALEHEFEDAEEEIIRKAEAIQTPLFKKRAELVEKIPHFWALVFEQAPPEIDNFIQPTDSKLIAECLSTVEVSRFELDDPNGSPRSFLLRLGFTENEYFEDKVLEKKFWFRKTRDWQGLVSEPVKINWKKGKDLTDGLTDAAYKLGQLRAKLAADTTNGAARNEEVKSAEYKKLAQMIETATDASISFFGLFSFVSGYRWVSAQESAQAVKEERERFEKVRRGEKIDDDEDEEDEDPFDYQEIEVFPGGDEVATIIAEDIWPNAIRYYKATFEEEEDDEELSDLDVMDDSDDDDDDDDDDDNDEPVDIRALVGKGRKSAQEPPAKKQRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF40</accession>
    <name>M2TF40_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_293877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697403.1">
        <property type="nucleotide sequence ID" value="XM_007699213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TF40"/>
    <dbReference type="GeneID" id="19136039"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_293877"/>
    <dbReference type="eggNOG" id="ENOG502SUW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127248_0_0_1"/>
    <dbReference type="OMA" id="HLARLTW"/>
    <dbReference type="OrthoDB" id="4502894at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="172" mass="19470" checksum="7728F4778D691810" modified="2013-05-01" version="1">MDPIIVLSIARRLVLHLARLTWWPIAKLITLAVILLRPFYLLVTFALLPFIHLAHAIFQVVSLPFTVKWLEQIETLYVFLGIAALIGCITGTTLFIMFKFLSSTLRINAPIVPEKPVETRTAAQYRAERRAKKGEAVHHLPAITPVILKKPNGPRRRGLLSQAIIEEEDSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI56</accession>
    <name>M2TI56_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_33312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695510.1">
        <property type="nucleotide sequence ID" value="XM_007697320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TI56"/>
    <dbReference type="STRING" id="665912.M2TI56"/>
    <dbReference type="GeneID" id="19137129"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33312"/>
    <dbReference type="eggNOG" id="ENOG502SMDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_0_1"/>
    <dbReference type="OMA" id="FGPENYV"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="309" mass="33401" checksum="466AD18C4E4F9A32" modified="2013-05-01" version="1">MTSVIVFGPTGQVGSVVARTAGELGAKVWLAMRDTSKNIPGLTKEAESAGDYHRIQADLEKPETVSQAVKTSGAKRAFIYLVHHASDHLHGAITAMKAAGIEFVVFLSSFTILVNKGLREIPSSDLLPYVHAQVEANLDDVFGSDYVAVRPGCFITNLLSEKAGIAANDVKLYGAGFKEDNMVPSDVGRVIGNIVVSGPKNGQKKVYLYGPQVYSHYESIAKIGEILQKDLKITILGPKEGHEKYMNSGMPKIFADYMVEVMGTNGIDKGNGEVFPNYEEGVSNVTLYTGQKPTSLEEWVKQNKALFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIA3</accession>
    <name>M2TIA3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_134165</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696044.1">
        <property type="nucleotide sequence ID" value="XM_007697854.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2TIA3"/>
    <dbReference type="GeneID" id="19130917"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134165"/>
    <dbReference type="eggNOG" id="KOG1920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001477_0_1_1"/>
    <dbReference type="OMA" id="WRESLYC"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Ohm R.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="MohdZainudin N."/>
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                <person name="Dhillon B."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695107.1">
        <property type="nucleotide sequence ID" value="XM_007696917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TMH4"/>
    <dbReference type="GeneID" id="19134479"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_215240"/>
    <dbReference type="HOGENOM" id="CLU_2413111_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="92" mass="10706" checksum="749C3A7B4170FB64" modified="2013-05-01" version="1">MYAYQLRTARQIQTRPEAHQMPPTHLCMYDGMIQSTYACRRCDLENSSIFLFLLQLLAPTALVFERLVLKWSRLQRVASPFQVHSETSNSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSL4</accession>
    <name>M2QSL4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_185965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445677">
        <property type="protein sequence ID" value="EMD58174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706127.1">
        <property type="nucleotide sequence ID" value="XM_007707937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSL4"/>
    <dbReference type="GeneID" id="19133538"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185965"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
    <dbReference type="OMA" id="NDCNWQF"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="167"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="392" mass="43640" checksum="3827ED6733586B7A" modified="2013-05-01" version="1">MVSAGLLIEALEGLDANSFVNEAERVRAMDALALALSKVHKPWDIVWQHCWVNPATNACVKTLIDAGVFSKWIKTGGGEKTCAELAELTGADVVLIRRMIRQISGQNLAIETAEDTYKPTPWVRALAEDQALANVYGGFYGFVNSPMFRTLPAYLKKTGYTIPTNPNDCNWQFMRGSNENLFQSLSANPAAAREFNDAMESHSKHNLTPWVDVYPTETLVKESKPDRPLVVDVGGSKGHDLTKFHLRHPDIPEGSLVLQDLPDILKELTIDDTISIHPHDFFEPQPVKGARVYFMHNVLHDWEDIQAKQILSHLAEAMEPGYSKLLIHESLVSSVKPLARVTTSDITMMACLGAKERTEAEWRALVESAGLKVLNIWRPPHSVESIIEVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2QUF1</accession>
    <name>M2QUF1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 12">Cysteine dioxygenase</fullName>
            <ecNumber evidence="3 12">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_41333</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="3 12"/>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705208.1">
        <property type="nucleotide sequence ID" value="XM_007707018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QUF1"/>
    <dbReference type="STRING" id="665912.M2QUF1"/>
    <dbReference type="GeneID" id="19139969"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41333"/>
    <dbReference type="eggNOG" id="KOG4064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079443_4_1_1"/>
    <dbReference type="OMA" id="YTENQVT"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000189">
        <property type="entry name" value="Cysteine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="10">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD58769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="206" mass="23419" checksum="53FA78F160EAB515" modified="2013-05-01" version="1">MIGRNTEVDEFRALVKAINEKLGPSSGIDSADVDEKELQQLMEAYVSNESEWKRYYFASDKVPYTRNLVDKGNGKSNLLILVWGPGKKSPIHDHANAHCIMKVLKGRLTETRFATPTDEDVKNHRPMKKTRETTYSENQVTYMADNLGTHRISNPDPTDYAVSLHLYTPPNAATFGCNVFKEDTSDVIHNKQCHFFSEYGVKMSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>M2QVR1</accession>
    <name>M2QVR1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Plasma membrane ATPase</fullName>
            <ecNumber evidence="4 18">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">COCSADRAFT_41056</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cell membrane</location>
            <topology evidence="2 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="4 18"/>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704843.1">
        <property type="nucleotide sequence ID" value="XM_007706653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QVR1"/>
    <dbReference type="STRING" id="665912.M2QVR1"/>
    <dbReference type="GeneID" id="19139901"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41056"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="OMA" id="VIEFHPF"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 18" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="862"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMD59179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="928" mass="101461" checksum="43769ACBE40625D6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2QWF1</accession>
    <name>M2QWF1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_258561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705143.1">
        <property type="nucleotide sequence ID" value="XM_007706953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QWF1"/>
    <dbReference type="STRING" id="665912.M2QWF1"/>
    <dbReference type="GeneID" id="19135382"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_258561"/>
    <dbReference type="eggNOG" id="ENOG502RR78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_0_0_1"/>
    <dbReference type="OMA" id="PRRKWVF"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29773" checksum="FF9C13CAFB561C5C" modified="2013-05-01" version="1">MSTPAPSTVRRSLADEETPLLGRNGADGGKSDAHATLHRMRCYMQTNVNRNWADVVLILCYMITGLLDSSAVFIWGSFVSMQTGNTVYLGLGIVAPSEGIRWIKAGISITAFCVGSFCFARFHRYFSPAKRWVLIASYSFQMLLIVFAAIITTFGKNTGEGLHWQVLLPLASVAFQSSGQAVTSRALKYNGLTSVVLTSNYCDLFSDPELFKMSNVERNRRIGAPLALVIGACMGGLFAHSSVGLAGSLWTAAGLKFMAIFAWALWKSEKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2QY94</accession>
    <name>M2QY94_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase ucpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_99488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704270.1">
        <property type="nucleotide sequence ID" value="XM_007706080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QY94"/>
    <dbReference type="GeneID" id="19141859"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99488"/>
    <dbReference type="eggNOG" id="KOG1207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="FPQWGAY"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD60019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="26384" checksum="7E8A300EC003A9AC" modified="2013-05-01" version="1">MGRLDGKVVLVTGGGSGFGAGISKGMASEGAKVLVCDINATGGQETCSANPSSLAFHQMDVTKSADWKASVAACIEKFGRCDILVNNAGWSYTNKPTTTVTEEEFDRVFDVNVKGVYLGCNAWVDQAIERGEGGVIINIASVGATRPRPGLVWYNASKGAIWNATKGLAAEYGPHQIRVVSICPLVTATGLFSAFTGMEDTPENRTKFTSNVPMGRIGEVDDVVNACIFMASKEAGFITGVNLEVDGGRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZC3</accession>
    <name>M2QZC3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_242584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703769.1">
        <property type="nucleotide sequence ID" value="XM_007705579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZC3"/>
    <dbReference type="STRING" id="665912.M2QZC3"/>
    <dbReference type="GeneID" id="19135042"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_242584"/>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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            <end position="154"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease III domain"/>
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            <end position="437"/>
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        <location>
            <begin position="603"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="723"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="EMD61429.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="731" mass="82920" checksum="D8B3F4B47D08466C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3A4</accession>
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            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="5 6">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702959.1">
        <property type="nucleotide sequence ID" value="XM_007704769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3A4"/>
    <dbReference type="STRING" id="665912.M2R3A4"/>
    <dbReference type="GeneID" id="19134835"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_234249"/>
    <dbReference type="eggNOG" id="KOG2523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090468_0_1_1"/>
    <dbReference type="OMA" id="GVENIHY"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000006">
        <property type="entry name" value="Translation machinery-associated protein 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="90"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="192" mass="21221" checksum="46B20AC46AA476A2" modified="2013-05-01" version="1">MFKKDITSGAKSKVKSSAQRGIRSKVLEEYPKLEPYIEDILPKKEQLDLVKLPDRVSLYTLNSTPLFFQHMDDALLPHLTLVHKYPFAFNRLRIDRGAIRFVLSGATLMAPGLTSPGGRLPGADLSDEDKEKYGAEELKEGAVVVIEAEGKETACMVGVLKMGTEEMKKVKKGQACEAGHYLGDGLWGLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3N9</accession>
    <name>M2R3N9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_146923</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702220.1">
        <property type="nucleotide sequence ID" value="XM_007704030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3N9"/>
    <dbReference type="STRING" id="665912.M2R3N9"/>
    <dbReference type="GeneID" id="19131393"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_146923"/>
    <dbReference type="eggNOG" id="KOG2719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_3_3_1"/>
    <dbReference type="OMA" id="FVIEEKF"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="42"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="230"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD61824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="462" mass="53026" checksum="9EDC534E40CE145B" modified="2013-05-01" version="1">MIQALLQRLARWLDRPQFPWKRLVVGFSLAEFALENWLLFRQYRVLQRTSIPKALDKEIEKETFDKSQQYGRAKAKFSFISGVFNQLKHLASLYFNLYPFVWTAAGTVLARYAPARFSGEISQSLLFMYMLGWIDLVAGLGFSYYHSFVLEEKFGFNKMTVKLWLTDMVKGQALAIAFGIPIGSAFLAIINKTGQGFFYYLWMFMLVVQITGMTVYPILIVPLFNKLEPLKPGKLKESVEALASKLNFPLSELQVIDGSKRSAHSNAYFTGLPWIGKKKIVIYDTLLEKSTEKEVEAVLAHELGHWKMNHTSRLLFISQAHLFYIFALFSVFINNRSLYADFGFHREQPTIVGFMLFNEILSPTDSIVKLLLNIWTRSMEYEAADAFAVKLGYARELGASLIKLQIQNLSSMDADWFYSSFHHSHPILTERLKAMKWTGEKKIVVDKAADEDKAVKAADREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2R9Y9</accession>
    <name>M2R9Y9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_37458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700429.1">
        <property type="nucleotide sequence ID" value="XM_007702239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R9Y9"/>
    <dbReference type="STRING" id="665912.M2R9Y9"/>
    <dbReference type="GeneID" id="19138989"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37458"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_1"/>
    <dbReference type="OMA" id="FATIKKY"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD63689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="325" mass="36017" checksum="29A6D51F4054F2D4" modified="2013-05-01" version="1">MPSSLDQLKAAGTTVVADSGDFATIKKYQPQDATTNPSLILAASKKPEYAKLIDAAVAYGKKNGTDIENQVDVTLDNLLVQFGKEILQIVPGKVSTEVDARFSFSTEQSVNKALRIIDLYKEAGIDKERVLIKLASTWEGIKAAEILQSKHGINCNLTLMFSQVQAIAAAEAGAYLISPFVGRILDWYKAANKKEYTKEEDPGVKSVQQIFNYYKKHGYNTIVMGASFRSIGEVTELAGCDYLTIAPNLLEQLYNSEDEVPKKLIAEDASKLDIEKKSYINDEAEFRFYFNEDQMAVEKLREGISKFAADAVTLKDILREKIQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBA7</accession>
    <name>M2RBA7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_89487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699994.1">
        <property type="nucleotide sequence ID" value="XM_007701804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBA7"/>
    <dbReference type="GeneID" id="19141300"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89487"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_2_1"/>
    <dbReference type="OMA" id="NYPWIHI"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
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        </location>
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        <location>
            <position position="560"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
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        </ligand>
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        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="595" mass="66008" checksum="75EE41BF599D1047" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2RD70</accession>
    <name>M2RD70_COCSN</name>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">COCSADRAFT_314350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VerF-like"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
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    </feature>
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            <end position="321"/>
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    </feature>
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            <end position="357"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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        </location>
    </feature>
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        <location>
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            <end position="321"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD64764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1073" mass="118464" checksum="82AB04A912D53001" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2RDZ4</accession>
    <name>M2RDZ4_COCSN</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="1 2">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699523.1">
        <property type="nucleotide sequence ID" value="XM_007701333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RDZ4"/>
    <dbReference type="GeneID" id="19133704"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_189992"/>
    <dbReference type="eggNOG" id="ENOG502SSBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1586319_0_0_1"/>
    <dbReference type="OMA" id="PWHWIEI"/>
    <dbReference type="OrthoDB" id="3679868at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="168" mass="19479" checksum="F0F9BBB43F5EE364" modified="2013-05-01" version="1">MSKFAPDNPESVSKAMLSWARENSHKVGRIAALDYGWEAWVQADLGLYLSVEASTTKAILRREETPYDDGRRVDLGIHGPDDTPWHWIEIKTQTPNQTKKKFLENLMADWKKLDNVVVGQYHARLWAVGFWPNDGEGKPENFANWGFEVANDMYVLYRTWYNPKFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2RF86</accession>
    <name>M2RF86_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_159084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
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                <person name="Dhillon B."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="128"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="445" mass="50009" checksum="5508A7E52F3B761C" modified="2013-05-01" version="1">MASHKRGGGFNHYSRDHHSKKHNPPLQRNAPQPELSSASMQTGLVALLDRFVAEETTPGADKEILYHANELRRRLCARDHGTSSQAKRELDAKRPDKAVQVAVPDYVHRKVQESKDLPPLPPIAEPHLHEAVFTHRSAIYDPSIPGSSLGGDLSLDYERLELLGDAYIELIASRALYNRFPHVDVPELCMWRERLVENSTLGKFSEAYGFPDRLKHRAQWDKNSKQYHKVVADMVEAYVAAVVLSDPTHGFEAAEAWLTELWAPQLLGFREKIIENPQARDQLNKLVLGKGVKLITKEEKPMTYDSNSVQCYHMGIYLTGWGYNDEWLGSGEGQNKVQAGVAAAADALKRDSPVLKDAIRQKDELRAARLKEQEEKAKINQGTDTPAVNSGGGGESGAKEKIDDDNNASSKKRKKEDESASPEQKKHRKEKKKKKETYSKILERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RM95</accession>
    <name>M2RM95_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_111846</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697324.1">
        <property type="nucleotide sequence ID" value="XM_007699134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RM95"/>
    <dbReference type="STRING" id="665912.M2RM95"/>
    <dbReference type="GeneID" id="19130166"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_111846"/>
    <dbReference type="eggNOG" id="KOG4123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022957_2_0_1"/>
    <dbReference type="OMA" id="HGIHPRY"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024754" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD67749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="516" mass="58797" checksum="84F99D14B8A83DC7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2RMD4</accession>
    <name>M2RMD4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_111920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697351.1">
        <property type="nucleotide sequence ID" value="XM_007699161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RMD4"/>
    <dbReference type="STRING" id="665912.M2RMD4"/>
    <dbReference type="GeneID" id="19130168"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_111920"/>
    <dbReference type="eggNOG" id="KOG3368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_4_0_1"/>
    <dbReference type="OMA" id="GKLMYGM"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000013">
        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD67789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="176" mass="19717" checksum="7C438B9D228F4FBB" modified="2013-05-01" version="1">MVLYSFYIFDRHTECIYSRRWTPARPTSSSSKPTTAAAAAARPTSGNSIVSNGDVVAAVRKGMSHSDDEKLVFGLVFSLRNFVTKLGGADDTFLSYRTGEYKLHYYETPTRMKFVMLTDTKVINLRQYLHQIWANLYVEYVVKNPLAPVEHPGGIGVANELFERGLEAFITAVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSV0</accession>
    <name>M2RSV0_COCSN</name>
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        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_106384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694901.1">
        <property type="nucleotide sequence ID" value="XM_007696711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSV0"/>
    <dbReference type="STRING" id="665912.M2RSV0"/>
    <dbReference type="GeneID" id="19129998"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_106384"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OMA" id="MFLKINM"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="654"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="767"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="864"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD69629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="909" mass="99650" checksum="D5C369E2F854F4D3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUJ8</accession>
    <name>M2RUJ8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_41388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705216.1">
        <property type="nucleotide sequence ID" value="XM_007707026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUJ8"/>
    <dbReference type="GeneID" id="19139977"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41388"/>
    <dbReference type="eggNOG" id="KOG4498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035338_0_0_1"/>
    <dbReference type="OMA" id="ENGECTW"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000404">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37424" checksum="9AF14DB6857A8446" modified="2013-05-01" version="1">METSEAKAAAPVPPPIMTSTPQPPATQVPSPPHSQSGLAADPKASMDVAENTTPPFSPSSQTPVLGREQEEFEGTLDVNNDIPTEKDLSAVADMLVLDAQGQSRPFKELYQAPHVASRQLIIFIRHFFCGNCQEYLRTLASSITPDDLLALPTPTFITVIGCGRPELIPMYTETTGCPFPIYADPTRKLYDYLGMTRTLNLGAKPQYMQTNVLINSVQSIFQGLSTGKKALKGGDFKQVGGEFLFENGECTWAHRMKTTRGHAEVSAIRGLIGLDSTRPPVRRRWSHEVKGPEKNRRRTVSWGRLRSKSKGGKDISVASSKQTTPDRILEEESEALAGISKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2RYQ5</accession>
    <name>M2RYQ5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_175251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704358.1">
        <property type="nucleotide sequence ID" value="XM_007706168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RYQ5"/>
    <dbReference type="STRING" id="665912.M2RYQ5"/>
    <dbReference type="GeneID" id="19132953"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175251"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OMA" id="WRWVDNG"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000013">
        <property type="entry name" value="Rh-like protein/ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF9">
        <property type="entry name" value="SIMILAR TO AMMONIUM PERMEASE, BUT NOT NORMALLY ACTIVE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD60158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="454" mass="49462" checksum="9BA6EEB78A066B2F" modified="2013-05-01" version="1">MGLPTEVLQAWAACDRTDTLFVLVCSVFCWGIIPAVGIAYSGYTTRSNSLAAIVPAVLSVIVCSIQWFLIGYTLTYGEGGAIFGDFKYAFHKGVLAEPVGTIPAVLFSFFQLVFQATVCAIAVGGACERGRILPLIPFIFLWSTFIYNPLAHMVWGGGFLMDLGVLDFAGGTPVHINSGASATAMSVYLSYPLFRSRKSSIRTPSHLVIHRPVNSLCQLLAMISIWGSWLAFDAGTTLAFNFKSVMALCVTNLCAASGALTWMLYTYMEVGRWSLDSCFMGAISGLIMITPSAGFIDLPTSFFFGILGALVCRQALRIKFTDFARRWRWVDHGDTFATHCIGGVLATISTGCFARKEVAGYDGVTEIVGGVFFDGNARQLGIQIMEALVGFTWSFIGSYVIYALIDCVPGFEVLAEDKDIIAGLDASQLDEETLWTETQKYYPYAELEGELHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZ81</accession>
    <name>M2RZ81_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_29589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703557.1">
        <property type="nucleotide sequence ID" value="XM_007705367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZ81"/>
    <dbReference type="STRING" id="665912.M2RZ81"/>
    <dbReference type="GeneID" id="19136074"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_29589"/>
    <dbReference type="eggNOG" id="KOG2111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_0_0_1"/>
    <dbReference type="OMA" id="GGPQCMC"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="392" mass="42660" checksum="9F3A349B360A2692" modified="2013-05-01" version="1">MNTRPILDSDTGPFVLSASFNADCSHFSVALETGFRVFSSTTCEERIAREVGGGIGCAEMLGNKSYIALVGGGKQPKYPQNKVRPEDSDWIWVDKTDIIYKVQIWNDKTERFTTSVEFKTPIQRVRLSQTHMVVALLNSVCIYKMKVPPVKTAEYETVNNPFGLLELGSNIVAFPGRAAGQVKIYDLNTGNVSIIPAHESPLRAIGISRSCDLIATASEQGTIIRLWSFPSCTKLAELRRGVDPAAVFSLAFSPDGSTLAVTSDKSTLHIYDLKTATAAAQADPAQHKYGILSKIPLLPRQFSDTYPTATAKFEMGDEPTSWGPHGKSATLSAGIPGVPGGRPTKGLIGWLDDQTVLVLGAGQDARWERFVMGVDDKGKKCLVANGWRRYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2S1D3</accession>
    <name>M2S1D3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_39757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703102.1">
        <property type="nucleotide sequence ID" value="XM_007704912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S1D3"/>
    <dbReference type="GeneID" id="19139562"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39757"/>
    <dbReference type="HOGENOM" id="CLU_2527302_0_0_1"/>
    <dbReference type="OMA" id="ASHVGIC"/>
    <dbReference type="OrthoDB" id="10312329at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="84" mass="9563" checksum="FE1358BA0F66834A" modified="2013-05-01" version="1">MPPHRNTATSPILPTHNQTLPANSQQASSDRSNRRHGRHKRKRAACWYKCGENVWRSRLDTASHVGICLAALMTLIFFLRRGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2S5F4</accession>
    <name>M2S5F4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_146103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701773.1">
        <property type="nucleotide sequence ID" value="XM_007703583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S5F4"/>
    <dbReference type="STRING" id="665912.M2S5F4"/>
    <dbReference type="GeneID" id="19131368"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_146103"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010236_4_2_1"/>
    <dbReference type="OMA" id="GIIRAGP"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="625" mass="70275" checksum="00490298011FD0B8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2S654</accession>
    <name>M2S654_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_56169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_56169"/>
    <dbReference type="eggNOG" id="ENOG502RH4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095015_0_0_1"/>
    <dbReference type="OMA" id="NNAYRPK"/>
    <dbReference type="OrthoDB" id="3787285at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="157" mass="18341" checksum="75D76E53052D1D84" modified="2013-05-01" version="1" fragment="single">LNNAYRPKDLQCLRHTFIILVQLAQKFESLLLAEALSTFWDHTKSKINRHEKSEYLADWKKAAEKVQESHATRPLAAFIQQRRGRARPAPAVKYGHRKVNFRLEVPAFANPACALPAIAPVRYPRDEYFDKLNKIQYQQREMKETLENVKGKLDRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6V2</accession>
    <name>M2S6V2_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_57594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701111.1">
        <property type="nucleotide sequence ID" value="XM_007702921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S6V2"/>
    <dbReference type="STRING" id="665912.M2S6V2"/>
    <dbReference type="GeneID" id="19140343"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_57594"/>
    <dbReference type="HOGENOM" id="CLU_000680_30_5_1"/>
    <dbReference type="OMA" id="THTTIKV"/>
    <dbReference type="OrthoDB" id="3942798at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD62878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="145" mass="16607" checksum="46BFA3A06B6A0E21" modified="2013-05-01" version="1" fragment="single">AAKAILNRKAKIFLKWAPGHTDIEGNEKADSLAKEATKQTPKESKTSLAFIGTKIKLLQRASQAEEWRKYREKAREKKTSYGAIFNLKLKNQLVIPRGTKREISSSFYSLKIGHGYFNAYLKRVKRRETELCKCGRPQTAEHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8L6</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_41482</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58925.1"/>
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        <property type="nucleotide sequence ID" value="XM_007707046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8L6"/>
    <dbReference type="STRING" id="665912.M2S8L6"/>
    <dbReference type="GeneID" id="19139997"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41482"/>
    <dbReference type="eggNOG" id="ENOG502SB4N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014048_2_1_1"/>
    <dbReference type="OMA" id="WELGTIP"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="580" mass="63534" checksum="E0F33F8456B5D1C6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8M7</accession>
    <name>M2S8M7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_330444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700067.1">
        <property type="nucleotide sequence ID" value="XM_007701877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SA72"/>
    <dbReference type="GeneID" id="19141304"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89579"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_7_2_1"/>
    <dbReference type="OMA" id="PWLDQPV"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="299"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD64208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="615" mass="69274" checksum="2A089F6165654CC5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAH7</accession>
    <name>M2SAH7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_40711</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704467.1">
        <property type="nucleotide sequence ID" value="XM_007706277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SAH7"/>
    <dbReference type="STRING" id="665912.M2SAH7"/>
    <dbReference type="GeneID" id="19139814"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40711"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1051"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1080"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="110"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="199"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="282"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD59515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1167" mass="123774" checksum="9F3788162B9C4C01" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAW8</accession>
    <name>M2SAW8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_152065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704649.1">
        <property type="nucleotide sequence ID" value="XM_007706459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SAW8"/>
    <dbReference type="STRING" id="665912.M2SAW8"/>
    <dbReference type="GeneID" id="19131580"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_152065"/>
    <dbReference type="eggNOG" id="ENOG502QRSY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034992_1_0_1"/>
    <dbReference type="OMA" id="PIWGLGC"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF46">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone/stilbene synthase C-terminal" evidence="5">
        <location>
            <begin position="265"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD59640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="48049" checksum="D9EF3F7802E4EE6D" modified="2013-05-01" version="1">MITQFHQHLNHHILRLSSTIGMTRSSNNDGVYITGLGHQYPEHAIRQEDFEGFLQRLYPEHVSSPAVQKLIGFNTKTQISSRPTVFDHTKWTQKDATPPTLGSISHDFRTVGVTLAASACKKAIQEARLESHEITHIVAVTCTNSDNPGYDLFVCEKLGLGPDVQRVLVQGVGCAGGLSALRAAADIAAAASLKRRKARVLVIACEICSLFFRAEIQNILQGGDETLRIAPALFSDGAAALVVCNELALAPSQAPVYQLREWASMVAPGTSSFMSYNFGKNGLIATITKDVPKAAISAIAPIFQQLCNTSNGAISNRVPLPQMPADFDWAIHPGGAAILHGAKDSLGLTNDHIRASLDVYKRYGNSSSASVLVVLDNMRHLGPGRDDVAAVSFGPGLTVEMCMMTRCRSSNLRMSVHRRQRASSFWAALQSRFSRKDAIHHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBQ5</accession>
    <name>M2SBQ5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
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        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
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    </dbReference>
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        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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        <property type="entry name" value="GNAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="238" mass="26904" checksum="D14ACE91EFF33247" modified="2013-05-01" version="1">MYLRPAQPSDEPAIVSICARAFYNEDLFGRVMHPHRDQYPEDLEIYWRGVVRRDWASPRNRVFVVVCPKNPEQNQHDKEEDEVVGMAIWQRQGNDATAQKIIQEHTDPTPLFQHIPARENRAADPTKKNHLADSAKYTEHYWSAPHSENWYLSLCAVDPAHAGHGYGRVLVQWGLDRARQEGVDASVISSETSPAFYLRCGFDEVVGNAHEGEGNPLQVDAVKGGDILFMWGGGKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBZ8</accession>
    <name>M2SBZ8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_40452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704086.1">
        <property type="nucleotide sequence ID" value="XM_007705896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBZ8"/>
    <dbReference type="STRING" id="665912.M2SBZ8"/>
    <dbReference type="GeneID" id="19139741"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40452"/>
    <dbReference type="eggNOG" id="ENOG502S18W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="OMA" id="TPLQYIY"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025253" evidence="2">
        <location>
            <begin position="20"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="4">
        <location>
            <begin position="140"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="3">
        <location>
            <begin position="358"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD60015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="769" mass="84066" checksum="D26CF52854073583" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCB7</accession>
    <name>M2SCB7_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_170772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699481.1">
        <property type="nucleotide sequence ID" value="XM_007701291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCB7"/>
    <dbReference type="STRING" id="665912.M2SCB7"/>
    <dbReference type="GeneID" id="19132711"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_170772"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1098406_0_0_1"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:DNA replication, removal of RNA primer"/>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M2SE95</accession>
    <name>M2SE95_COCSN</name>
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            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
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        <name evidence="14" type="ORF">COCSADRAFT_35616</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
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    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD65578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2355" mass="262410" checksum="8A9CAA686E5905CB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFG3</accession>
    <name>M2SFG3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_58006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698457.1">
        <property type="nucleotide sequence ID" value="XM_007700267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFG3"/>
    <dbReference type="STRING" id="665912.M2SFG3"/>
    <dbReference type="GeneID" id="19140347"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_58006"/>
    <dbReference type="HOGENOM" id="CLU_527442_0_0_1"/>
    <dbReference type="OMA" id="HREKTFR"/>
    <dbReference type="OrthoDB" id="3688235at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="484" mass="55314" checksum="2534FF941ACAF1CD" modified="2013-05-01" version="1" fragment="single">LPVPEWWLHYVGVDKRKVCRCSHPARHREKTFRLIKEWPELEASLNFYMDRMNYKTCTIAEYMDYQLKREKLWENAGIYIRSFHWADPARMFVCRCAERTCYKYSMLKDPVQMEQCAEYFLLHRDEITASQEKWERHDEDLPPPYAPNAQSELKYSRQQYQRPTQNEHTSKPSQRIPKPEMGMRGSAEPLTPRFVEPRKDGAAMQQESEMPPQVWRHARPSLWKYSDGNSSSASTPLGSSFYAPSEEPRVPATAPLENRPAPWNGSDSGYSSTQKHQGQRDARAEGIHSRSKSYELDHDRADSSFDMHSMHSGIGTIPISKSSTSSSQSSSKLKPTMSIPDAPEQENDADSYTPTIDLYFRIADEDETNISSVYRQSNPPSTASSQNLPFFYENYLSDNSHKEAVQKDVAELSPEAYYYGDRYAIPTGHDNQNKGSSGHISELSAETPAAELSADAPRQRHTPTLNALEGRDWGTIPEMEAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2SH39</accession>
    <name>M2SH39_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_39427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702646.1">
        <property type="nucleotide sequence ID" value="XM_007704456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SH39"/>
    <dbReference type="STRING" id="665912.M2SH39"/>
    <dbReference type="GeneID" id="19139494"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39427"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD61725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="449" mass="48923" checksum="35C1C5A731070BC0" modified="2013-05-01" version="1">MSAPAHKFKVADISLAAFGRREIELAENEMPGLMETRRKYAEDQPLKGARIAGCLHMTIQTAVLIETLKFLGAELTWTSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYEWCLEQQLTAFKDGKSLNLILDDGGDLTALVHKKYPEMLKDCYGVSEETTTGVHHLYRMLKGKGLLVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKVAVVAGFGDVGKGCAQALHSMGARVIVTEIDPINALQAAVSGFQVTTMEKAAPQGQIFVTTTGCRDILTGAHFEAMPNDAIVCNIGHFDIEIDVAWLKANAKSVTSIKPQVDRYLMKNGRHIILLAEGRLVNLGCATGHSSFVMSCSFTNQVLAQIMLYKASDEAFGNKYVEFGKTGKLDVGVYVLPKILDEQVALLHLAHVNVELSKLTDVQAEYLGLPVEGPFKSDIYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SL19</accession>
    <name>M2SL19_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apoptosis regulator Bcl-2 family BH4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701016.1">
        <property type="nucleotide sequence ID" value="XM_007702826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SL19"/>
    <dbReference type="STRING" id="665912.M2SL19"/>
    <dbReference type="GeneID" id="19139110"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37857"/>
    <dbReference type="eggNOG" id="ENOG502QSSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036627_0_0_1"/>
    <dbReference type="OMA" id="NHWNAWK"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47601" checksum="FB5E9FCC9180FAFE" modified="2013-05-01" version="1">MFSLPRISLPSFLRGGEGSYLTVNLPSVEIHDIETAAEKRPRTLKHLLKANHANYGILYHNLIFHNHAPHILGSAYLLGGTAEHLNDIYEKEAEELEPWQDAPGEITKDDWRDFLGKPEYQRAFIDFFEDQLVTKKYSVEQVLEEFLFEGKEPLINGMISGLAHPLIHLGYAYELNSKTVAIEALAMGSCCYSSLHKYVDDPKYTKPSPHSATGAQSGLIGLLDKVRQDSRFDGLYDDRSGDITKVLEEQEEALLEYWNAWDITSPTEQFRAAQEVGMGLLVGTPALSHGKYDFFIVHVLTSSHAVRILLPLVPAKFHVSLLRQWWLFALAVYIAQTRPVIDMDKAIPGEDSKKSWKHVVDKALNGPHAKDAHYVKALRALKVAEETWGASDNASSHWLNAAVKFADEFEGWGGFGTAEDEAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLX0</accession>
    <name>M2SLX0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_359607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701483.1">
        <property type="nucleotide sequence ID" value="XM_007703293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLX0"/>
    <dbReference type="GeneID" id="19138629"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_359607"/>
    <dbReference type="eggNOG" id="ENOG502RJ9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1441871_0_0_1"/>
    <dbReference type="OMA" id="KHLRWEC"/>
    <dbReference type="OrthoDB" id="3686475at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="188" mass="21491" checksum="1F8A475E4AB2E15D" modified="2013-05-01" version="1">MIVSSITANLFLGLVVLTSAILIVIIIYLLIRFVNRPKRKVNLRQDFEPRLLDPESSRESRLSHRLSRQQTQREQREDLLQHYSSVSRPPSIELLPKIKTSSSDDRASEWLEQGVSDKGFDVVEGDLGEKKHEMRQVAVMKPKKHLRWECTDENMDGCDRVPGVAEDTKGDRTACTEYQSEKALDVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLX2</accession>
    <name>M2SLX2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_33130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695459.1">
        <property type="nucleotide sequence ID" value="XM_007697269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLX2"/>
    <dbReference type="GeneID" id="19137048"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33130"/>
    <dbReference type="eggNOG" id="ENOG502QRGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032158_1_1_1"/>
    <dbReference type="OMA" id="GSMPVCH"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="49604" checksum="CC60FEE4A0C96EB3" modified="2013-05-01" version="1">MSYLQNSLRRFRRTQTHNVDTIRLQPLAELSGSLGDLGTLLPLMTALVISNSISLPSTLLFTGAANILTGLSFGLPLPVQPMKAIAAVAIARKFSLNENAAAGIVVAVLVGFFSVTGLLNWANRVTPIPVVKGIQVGAGLSLCLSAGSNMLLPLTWTGPWWGDNLLWALAAVLLLLCTFAHPRMPYAMIVFTTGIILSLASSQDADITVPEAAIPILHPSSHDFWTAISTASLGQFPLTILNSVIAASALATDFFPSPPYPIAPTVTELGVSVTAINLVGCWFGAMPACHGSGGLAGQYRFGARSGSSVILLGSLKFTLGLVAFWNSPAIITLLANIPKSLLGVLVLAAGLELARVGESVNTDARDLRVLERDLTWDGKRVRELDERDRKERWTVMLVTVAALLTFKNDAVGFVAGLAWHWGFDVARRVQGWRHGESEGRVWMTVGHGRDESAGLLAHTESDTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SM15</accession>
    <name>M2SM15_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_191532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701524.1">
        <property type="nucleotide sequence ID" value="XM_007703334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SM15"/>
    <dbReference type="STRING" id="665912.M2SM15"/>
    <dbReference type="GeneID" id="19133770"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_191532"/>
    <dbReference type="eggNOG" id="ENOG502RGZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_4_3_1"/>
    <dbReference type="OMA" id="FYMGVDY"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025114" description="endo-1,3(4)-beta-glucanase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="34"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD63345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="591" mass="61089" checksum="F1FEF7AEBA6920C3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMY5</accession>
    <name>M2SMY5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_330260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700707.1">
        <property type="nucleotide sequence ID" value="XM_007702517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMY5"/>
    <dbReference type="GeneID" id="19137010"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_330260"/>
    <dbReference type="HOGENOM" id="CLU_2512297_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="86" mass="9092" checksum="D252D38974A9CDCF" modified="2013-05-01" version="1">MDDDATGDPARPATRGPAVRVLSEGASWRCRKRCIRRAAGGWGFGGGGGGGAGVGGLDGWVDGWMDEAVERGMRWMHCAREFSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNW9</accession>
    <name>M2SNW9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_176082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705319.1">
        <property type="nucleotide sequence ID" value="XM_007707129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNW9"/>
    <dbReference type="STRING" id="665912.M2SNW9"/>
    <dbReference type="GeneID" id="19133008"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_176082"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_0_1"/>
    <dbReference type="OMA" id="YYDEQLA"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="93"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="328" mass="36061" checksum="D4FCCC483D1B2011" modified="2013-05-01" version="1">MSTAYFLSRSLLRAFSPFKFRRASTPLYSSRCLATPSNPHGASVAAGVRVDHAEEIDNQTVAAMGRTKAGKSLKVRKYPTFTRLEDERLYRKQHLAAAYRVFASRGFDEGVAGHISVRDPIMTDHFWLNPLSTHFSLMHVSDLILVNEEGEVVEGDQPINAAAFAIHSAIHKRRPEVHAACHAHSVHGKAFSAFGRELDMITQDSVRFYKSHGVYNQFGGIVLASEEGERIADALGDGKAAILQNHGILTVGKSVDEAAFWFLSLDKTCQAQLLVDAAAAGSGHKPKIIPESEAAETYKQVGTPEKGWLAFQSYYDEILAKTNGEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNX8</accession>
    <name>M2SNX8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_116875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699917.1">
        <property type="nucleotide sequence ID" value="XM_007701727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNX8"/>
    <dbReference type="STRING" id="665912.M2SNX8"/>
    <dbReference type="GeneID" id="19130341"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116875"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OMA" id="WNAPIFT"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="484" mass="52585" checksum="443F10779E09193F" modified="2013-05-01" version="1">MAESIETRLFINNEFRSARSGESFTVKRSYDDSIIAENVQIAGEQDVNDAVDAAHAAFKHWRKTPAPERAKCMLKLADLIEENLEWLAELETAAMGAPISATKWIASTMPTWWRYYAGWTDKLGGESLEDLDGSYRMVRYEPLGVCAGIASWNATLFYLSWKIAPAVAAGNTFIFKSSEKSPLGALRFADLVRRAGFPPGVINLITGFGQTGGLLASHQNIRKISFTGSTLTGRKIQIAAANSNLKRVTLELGGKSAAIVFNDADIDEALTHMSQTFLLNCGQVCAATSRLLVQDTIAESFVAELKTRFQGFAKALGDPSDPNTFLGPIADRMQRDRINSFIDAARTENLNILAGGQSQGPQSQFIQPTIILDPPSSSTLYRDEIFGPVLVIKTFKSEAEAIDMANDSAYGLGAALFTKDVPRALRLSSDLECGFVGINMPITPSAYTPFGGAKESGYGREGGRMGLMAYMEPKTVAIAMKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPG4</accession>
    <name>M2SPG4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_26372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699718.1">
        <property type="nucleotide sequence ID" value="XM_007701528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPG4"/>
    <dbReference type="STRING" id="665912.M2SPG4"/>
    <dbReference type="GeneID" id="19135493"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_26372"/>
    <dbReference type="eggNOG" id="ENOG502ST1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602655_0_0_1"/>
    <dbReference type="OMA" id="CEWRRAT"/>
    <dbReference type="OrthoDB" id="5328813at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="455" mass="51328" checksum="8366493F4C62C14D" modified="2013-05-01" version="1">MTERKSPGRLQPHHRQPQSQSTSTSNNTTTPPKASRPAPNMPKDQARRRIFPLNDMHKHQSGRTPGPTQPTTNIEDPAPPSQDATNESGQQPTQSPSDTEKVRRDSSNLWESTMNDAVQRESEELVRQNHELRCQVAQLEDQLMYPNSARQHSDRPKSTGQVGDLKLRLQAAEKESQERLQQIISLKSSISSLTRVQSQVTDSDLVASLSELANRVREWTISTLRRTKLNLENLPKETEETVCKLYPQYRNGIQGADKFALYQAIISTLLMPIFETPLVFGLPTSLAAIQSFADEVHDSGPAFSEWKRATIQVLESSRIQPDLVREQEELLHRILGDVCHLFFTLTSTTITSSAQLALSGILKNAVDFQRTLALQKARYQLLFFRSEGRKMYLDDRTMEAINDADSTMDDDTVMEADRTFLFCAFPGLVKHGDEWGEHHEMSNVLLKARVCSGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPQ1</accession>
    <name>M2SPQ1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_103432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705775.1">
        <property type="nucleotide sequence ID" value="XM_007707585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPQ1"/>
    <dbReference type="GeneID" id="19129846"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103432"/>
    <dbReference type="eggNOG" id="ENOG502S0NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033551_0_0_1"/>
    <dbReference type="OMA" id="NHAWLAL"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="392" mass="43301" checksum="85FABAD43570993A" modified="2013-05-01" version="1">MDNDRRPRHTPSGYASQQGTLLPPQASYPVVSAPDRFRQPPLTAPAPPTSLPSSGSRASPQGYGYAYGESAQFGSSVQPSNVSYSAQDYGTDQQQQAQRTPQQYSPYGQNIMYGAQASATGSSQYEPVEQYQQNRDSAIQVLSTGFGVAQQQYYEGGPTSAPAATIASQSVPSQYPSLAYTASQTQVGREALAPAYSAAGMTDPNQATSQPGYPQASYSESQSGSGNDYDDFYRTYQSELKKTFEHVRDSRLSEAGTMLFRMSDWLLHFAETLAGLVRDDETYYQQRLQLWEEFNTCWLSTLQKQKAMTQEMINTGQRPQAPKSLIDYDFLEKMGTQLVKNCDSMEKHGLVDYQMGVWEEEIVAMLTSCMDLLEEVGAGPSAQRPTSTARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPR5</accession>
    <name>M2SPR5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_348585</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705519.1">
        <property type="nucleotide sequence ID" value="XM_007707329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPR5"/>
    <dbReference type="GeneID" id="19137903"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_348585"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="OMA" id="SCMTTDI"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Condon B.J."/>
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                <person name="Lindquist E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705164.1">
        <property type="nucleotide sequence ID" value="XM_007706974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQR4"/>
    <dbReference type="STRING" id="665912.M2SQR4"/>
    <dbReference type="GeneID" id="19135397"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_258920"/>
    <dbReference type="eggNOG" id="KOG3999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035754_0_0_1"/>
    <dbReference type="OMA" id="VCWMRLE"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="326" mass="35548" checksum="2A358D81EAF85873" modified="2013-05-01" version="1">MQQADRMRFKASIQNITTFTKLTASLNSLGPLAWVKLSEEQVCFTIIPEQGTQVWAVLSIDSIFETISVQSAANNVINLEVPLASLNRALKSAINATSAQIRLTKKDNLPMLALTIVTTTAFESDFGGGNRETIVTQEIPVRVLAPDTVAHLHEPACREPDVHIILPPLMQLKSISDRFTKLALADTKTGSTTTSARTRLEIAANMHGCLKMSIRSDAMNISSIWTDLNNPELDPGHVAGGENGIAEHPSTRMKQLGSADGRSDEGWAVVRIDGRDWGKVMSVGRLGGRVIACFCHEHALILYVYLPNDNGEDESVLTYFISSYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQS2</accession>
    <name>M2SQS2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_140619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699247.1">
        <property type="nucleotide sequence ID" value="XM_007701057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQS2"/>
    <dbReference type="STRING" id="665912.M2SQS2"/>
    <dbReference type="GeneID" id="19131171"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_140619"/>
    <dbReference type="eggNOG" id="KOG3894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047847_1_0_1"/>
    <dbReference type="OMA" id="YRIRTHI"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="266"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD64630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="356" mass="39893" checksum="B4640FC6AF165547" modified="2013-05-01" version="1">MDITPTFNQVLAKHNAPPIKPFKFRVEALDDFVKEAYRIRTHITKLHTDLKSIRQSYLSTANPPRRKQLARSSTSSTVDKDSKYLSDAQRNEIDLQAKQSIRQLNDAIKTLGVAEQARQAAQSQVALRKRAKQGLGALGRWAAGGAITAKSPEEEIEEAKANTIKAHRESIIWSLQKQLEECGQFQSNMMEIRLTREVEKSKSVLHKTRITAPAMADYNEPKGGQGAEADYRGTASYNPDEGSTVIENQLDPEQLQLFAQENQDMLKQYEDQLDKIRATEKSLTEISELQSTLASNLSMQAAHIDQLVEDSLNTQENVGSGNKELKRATERGSTAQKVFWATSVFCATLVLWDLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR37</accession>
    <name>M2SR37_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_32393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694281.1">
        <property type="nucleotide sequence ID" value="XM_007696091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR37"/>
    <dbReference type="GeneID" id="19136755"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32393"/>
    <dbReference type="HOGENOM" id="CLU_2573716_0_0_1"/>
    <dbReference type="OrthoDB" id="10392813at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="81" mass="9265" checksum="83F9F2FF21D2059B" modified="2013-05-01" version="1">MDRGARVRVCPCFLATANGFTLLAINGLAMLDDQHKQGAAVRRDSIKRKYTKGNMEYTPKEKRYDDNDVAGEMKKQKKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRI7</accession>
    <name>M2SRI7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="15">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_30866</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="15"/>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704825.1">
        <property type="nucleotide sequence ID" value="XM_007706635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRI7"/>
    <dbReference type="STRING" id="665912.M2SRI7"/>
    <dbReference type="GeneID" id="19136334"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_30866"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="242"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD59417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="441" mass="49980" checksum="3A117E7945FE1E1A" modified="2013-05-01" version="1">MQSPPSIPIAPSPTTYIKLEQYGYAIQDADKAIEIDPNNVKAYFRRASANTAILKHREALRDWKLVVKKAPNDANAKLRMTECDKIVKRDAFLKAIEVEDAPSAAEGLDLEHMVVDPSYDGAKLEDKMTLEFIEDMIERFKNGKKLAKKYVYQIIIAVMDIIKKEPTMVEHDVEQGHEITVCGDTHGQFFDLMEIFRLAGKPSEKHAFLFNGDFVDRGSWSTEIALLLYAYKWLYPNSFFLNRGNHETDDMNRMYGFEGECKAKYTERVFKLFSESFSALPLATLIGKKYFVLHGGLFSDDQITLDDVRKLNRFKQRQPGQSGLMMEMLWTDPQTSPGRGPSKRGVGLQFGPDVTKRFCENNGLEAIIRSHEVRMGGYEVEHDGRCITVFSAPNYCDSTHNKGAFIKIGPDYKLSFTQFDAVAHPNIKPMAYASQGMAGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRN3</accession>
    <name>M2SRN3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_347375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704730.1">
        <property type="nucleotide sequence ID" value="XM_007706540.1"/>
    </dbReference>
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            <end position="244"/>
        </location>
    </feature>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <dbReference type="GeneID" id="19134634"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_22342"/>
    <dbReference type="HOGENOM" id="CLU_062481_0_0_1"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
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    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
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    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD70203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="345" mass="38953" checksum="33578AAC5C0C5E8D" modified="2013-05-01" version="1">MDDEGPKWRLDHADTGLSTCQQAACKRNKTKIGKGELRIGTHTLFDNGIERRWYMAWRHWECATKHQIAGLKETTENDPTKAPGYDRLSQKSQEQVRLAFEEGMPFDKGFKDIREDLAKTSCKYAKEYRDAECYKADVATRAAACRGCDCVSDNIKITKGHLRLGILVNFDGDHTSTYYKHWRCMSEYDLACAQMCYEKGEFYGIDKIPEELKEVVLKTLETGEVVEPPEPKIVPPKARAKPKLKTSRSKKTKVKPEPSISSEESEGPLEDLSDELQETIPPSPATKPKAKKSKAKRRPAKEIDSSSEAEPEYIPRKSRSRSSPFKEANVLAEAATSAPEDLMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSX1</accession>
    <name>M2SSX1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tctex-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_40596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704130.1">
        <property type="nucleotide sequence ID" value="XM_007705940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSX1"/>
    <dbReference type="STRING" id="665912.M2SSX1"/>
    <dbReference type="GeneID" id="19139785"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40596"/>
    <dbReference type="eggNOG" id="KOG4081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109453_1_0_1"/>
    <dbReference type="OMA" id="YKFACNS"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21456">
        <property type="entry name" value="DLC-like_SpDlc1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14982" checksum="D3B39BC18BC04968" modified="2013-05-01" version="1">MASHSPLPTDDLQQIAKTACEQAVGAATSYDHTKVGDWNSEIIQYILKTLISKTTPTADSSNPDAPSQPAYKYIANSTVIQHHGNSPAEIEKQGRRGMHSAVGAFWNNEKDGTYTYKWEAADSKGMDIVITITWIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST30</accession>
    <name>M2ST30_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_35496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698326.1">
        <property type="nucleotide sequence ID" value="XM_007700136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2ST30"/>
    <dbReference type="STRING" id="665912.M2ST30"/>
    <dbReference type="GeneID" id="19138330"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35496"/>
    <dbReference type="eggNOG" id="KOG2819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032056_3_0_1"/>
    <dbReference type="OMA" id="YRKNDQK"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="520" mass="57610" checksum="F1235425502BCA65" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUD7</accession>
    <name>M2SUD7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_193114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703770.1">
        <property type="nucleotide sequence ID" value="XM_007705580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUD7"/>
    <dbReference type="STRING" id="665912.M2SUD7"/>
    <dbReference type="GeneID" id="19133839"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193114"/>
    <dbReference type="eggNOG" id="KOG3326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943336_0_0_1"/>
    <dbReference type="OMA" id="EMEGAKF"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="318" mass="35153" checksum="3E6C0D6D2E4C9684" modified="2013-05-01" version="1">MASSRIVTRSSRALLSLQRTQCRTFSIAPLRNGEFDALNKRTNDTSETYRKYQIEKPLNPHLTNSASTIANKMPSVGKDSAPPELITQVDDKFAPKDSSPENTERMTGGTQSSKAQDVSGTNSELGVGEMEGAKFKVEPLKRTGEDANTMRARLLYQSRKRGTLESDLLLSTFADAHLGTMSPSLMQQYDTFLDENDWDIYYWATQEPTPTSHETAEGGGSTLSTSNAQGLDAATQTKLPEKDERKRDPGEGEWAQTVGTFKPAYRPVPTRWKGSEILSLLRKHVNERKAGGVIEGEGQKQQEGKGLGMMPEVKNFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUT5</accession>
    <name>M2SUT5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_174163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703214.1">
        <property type="nucleotide sequence ID" value="XM_007705024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUT5"/>
    <dbReference type="GeneID" id="19132898"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_174163"/>
    <dbReference type="eggNOG" id="KOG0247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009436_0_0_1"/>
    <dbReference type="OMA" id="DECYHEM"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000091">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="453"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="910"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="920"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="548"/>
            <end position="555"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122449" checksum="B708BB46A0267D3E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVY2</accession>
    <name>M2SVY2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_149732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703468.1">
        <property type="nucleotide sequence ID" value="XM_007705278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVY2"/>
    <dbReference type="STRING" id="665912.M2SVY2"/>
    <dbReference type="GeneID" id="19131506"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_149732"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_12_1_1"/>
    <dbReference type="OMA" id="KQIMRAM"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="161" mass="17377" checksum="AC72D27782A7E211" modified="2013-05-01" version="1">MTALKFVRSVWESFRANSGLEPRLLNGLRVTSAVPGRVKFELDIKKEHTNRLSILHGGTIASMVDLGGSLAVASRGLFATGVSTDLNVTYLSSGGKVGDLIKAEVSCDKFGKTLAFTSINFSNSKGEIFARGSHTKYVALAWKDPNNIVEELSPKSSEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWW9</accession>
    <name>M2SWW9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_231768</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702799.1">
        <property type="nucleotide sequence ID" value="XM_007704609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWW9"/>
    <dbReference type="STRING" id="665912.M2SWW9"/>
    <dbReference type="GeneID" id="19134786"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_231768"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_3_1_1"/>
    <dbReference type="OMA" id="DMHVSGI"/>
    <dbReference type="OrthoDB" id="5295093at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="15">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="14">
        <location>
            <begin position="297"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD61461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="486" mass="53050" checksum="37D8AE606BD47A3A" modified="2013-05-01" version="1">MSAKSILEADGKAILNYHLTRAPVIKPTPLPAQATHNPPPKLASLYFPADEDVKGVLDQAEATYPWLLTPGSKFVAKPDQLIKRRGKSGLLALNKTWPEAREWIEARAGKEQRVETVDGVLRQFLVEPFVPHPQDTEYYININSVREGDWILFTHEGGVDVGDVDEKAEKLLIPVDLKEYPSNEEIAATLLKKVPQGVHNVLVDFISRLYAVYVDCQFTYLEINPLVVIPNEEKTSAEVHFLDLAAKLDQTAEFECGAKWAIARSANALGIAAAPAKDGKTTIDVGPPMEFPAPFGREMSKEEAYIAEMDAKTGASLKLTILNATGRVWTLVAGGGASVVYADAIASAGFASELANYGEYSGAPTETQTFHYARTVLDLMLRAPQHEEGKVLFIGGGIANFTNVASTFKGVIRALREVAPLLIEHNVQIWIRRAGPNYQEGLKNIKSVGQELGLNMHVYGPEMHVSGIVPLALIPGKTTDIKEFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX20</accession>
    <name>M2SX20_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_230741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702744.1">
        <property type="nucleotide sequence ID" value="XM_007704554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX20"/>
    <dbReference type="GeneID" id="19134770"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_230741"/>
    <dbReference type="eggNOG" id="ENOG502SWHW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137468_0_0_1"/>
    <dbReference type="OMA" id="ETGYQWS"/>
    <dbReference type="OrthoDB" id="5377039at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="149" mass="16329" checksum="2FE1F067CBC45B87" modified="2013-05-01" version="1">MSDRDGDSTMHSSPRNASDDEMFPDEALPNNPATPHNANLAAVNEISPPNSQSQTRETLGVNSNGKRPLSGGTMQSSATNTLSTSGTHTDPETGYQWSKQEDQPGYEWMNTRAREEENRALDNIVDKGYMIKLRYGDPLDASVAAKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYC3</accession>
    <name>M2SYC3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_82931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697012.1">
        <property type="nucleotide sequence ID" value="XM_007698822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYC3"/>
    <dbReference type="GeneID" id="19140922"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82931"/>
    <dbReference type="eggNOG" id="ENOG502SSEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_1_0_1"/>
    <dbReference type="OMA" id="MGADREW"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623:SF17">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="525" mass="58708" checksum="3E369316C6D2706B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYU5</accession>
    <name>M2SYU5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_226369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702321.1">
        <property type="nucleotide sequence ID" value="XM_007704131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYU5"/>
    <dbReference type="GeneID" id="19134684"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_226369"/>
    <dbReference type="HOGENOM" id="CLU_1277429_0_0_1"/>
    <dbReference type="OMA" id="CATMPNQ"/>
    <dbReference type="OrthoDB" id="3694042at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="208" mass="21749" checksum="1DBB65C74F42386D" modified="2013-05-01" version="1">MDGCATMPNQHAQLPCTSARPPYVLSQQATSISSSPALPSYCARFCGLQGIPLVRPGCVSHDDMVLRGAALCRPIRKVLLLLLLLPRAVCQGPVTESAIAATQSSLSIARRSTWGLPAPYLSTGPNSQSASSLPCLPRLSGFAAAVQDLGAAACTSPGNEPWFTIHTPHRAPFLPANIALAHDAHFDAGAFAQHSRSTKPVTLGVTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYX1</accession>
    <name>M2SYX1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_290001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697155.1">
        <property type="nucleotide sequence ID" value="XM_007698965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYX1"/>
    <dbReference type="STRING" id="665912.M2SYX1"/>
    <dbReference type="GeneID" id="19135970"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_290001"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="OMA" id="HTFPTAW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
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    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="94"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="355" mass="38566" checksum="40EFEEE464B46E9E" modified="2013-05-01" version="1">MALDFSQYGGPSEEWLALEKTLPQLNFDTSADPATLQKFVNAEREGKAAEAMQHFTPHVTTKDYSIPTRDGSTIEARSYRPVEKDASEKLPVYLYFHGGGFIFGSIKSEDPTCAQTAIKTDCVVLNINYRHAPDHVFPTAWLDSQDAFAWLHKNIEEVGGDPSRVIVGGVSAGGTLSSSLALEQHLGKSDVTKDLPKLIGQVLIIPCLSSPYTYDEGPAKKLKVPSYVENANAPLLSANVANFFAGLLQTGKPDLKCTKLNVGNATEDEVKGMPPSVFGIAGLDPLRDEALLYAKTLSEANVPTDITVFKGVPHGHRRFGNALKASEHWDQCINNGILWILSKPEATGKFNVKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZ97</accession>
    <name>M2SZ97_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_136808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZ97"/>
    <dbReference type="STRING" id="665912.M2SZ97"/>
    <dbReference type="GeneID" id="19131028"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_136808"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_1"/>
    <dbReference type="OMA" id="MPIRKEG"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000136">
        <property type="entry name" value="DnaJ domain-containing protein Psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="376" mass="40084" checksum="8A3C3E66B972883C" modified="2013-05-01" version="1">MVKETKLYEALGISESATQDEIKKAYRKAALKWHPDKNKDNPQASEKFKECSQAYEILSDPEKRKTYDQYGLEFLLRGGVPQEDAGGPGGNPFAGAGGPGGFPFTSSGGMPGGTRTFHFSTGGGGGNGFNFSNADDIFGEFMRNSAGGGGGGDDFDFGGFGMGGMPGGMGGMPGMGGMGGGAGGKGGRFRGGRRAPEPEVTVVEKPLAVSLEELYNGTTKKLKIKRKTYDQSTGKQSTQDRILEVPIKKGLKPGSKIKFSDVGDQVEGGTQDLHFIVSEKPHAMFTREGDDIKHIIELDLKEALTGWRRTVQTIDGKQLSVGSGGPTGPNWTERYPNLGMPKSKKPAERGDFIVGVKIKFPTSLTSAQKEKLKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZQ8</accession>
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        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_158155</name>
    </gene>
    <organism evidence="9 10">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697362.1">
        <property type="nucleotide sequence ID" value="XM_007699172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZQ8"/>
    <dbReference type="STRING" id="665912.M2SZQ8"/>
    <dbReference type="GeneID" id="19131875"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_158155"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051898_7_0_1"/>
    <dbReference type="OMA" id="LWRCVTS"/>
    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD67805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="263" mass="28521" checksum="44C004B7FCDC33E4" modified="2013-05-01" version="1">MDVFWTLPPVSRTITAAAVVVSALGYGGILNLYHVIFATQYVFTTKMIPQLWRIFSAFLLTKPKFGILLDPYFLYQYGSSIERESSRFSQPGDFFVYTMFVGSVIVGTAGCLLGSYTFLPALSLAYAYTFGQDNPTRSVQFFILNFDAKFLPFAMLFLTFVIDGPDAAASQLTGLIAAHLYDFLTRIWPTFGGGTNYIRTPQIVKGWFSATAGSVQDRGYGHAVQGRGRAAGAPGSGAQPTTGRTTGANTPWSGMGPGRRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZT7</accession>
    <name>M2SZT7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_200976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701708.1">
        <property type="nucleotide sequence ID" value="XM_007703518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZT7"/>
    <dbReference type="STRING" id="665912.M2SZT7"/>
    <dbReference type="GeneID" id="19134173"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_200976"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026457_5_0_1"/>
    <dbReference type="OMA" id="PQRAYKN"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43760" checksum="24460A787C0F0DC1" modified="2013-05-01" version="1">MAKSTAVTKKTEKATEAPLTTKPVNGTPYQLDPSQVERAAKALVAHMKKHVEEKQEKAPTKSLAADEDGAEEVDEPIFLSLSTKKQIANTKSMKPVAIKLPHPIIASDVRVCIFTKDPQRAYKDLVASDAFPAALRAKVQRVLGVEKLKKRYKAFEQKRALLAEYDVFLVDDRVIKIVAEFLGKVFYKSKSKRPIPIRLTAGAYIDKSAKKDSKESKDLVGTPQGVAKEIESALNSTYLSMSPSANTSIKVANLFMTPQQIAENTAAVVSEVVDKHVGQGWRNIRSLHVKGPATKALPIWLAEELWVEDSQVRDGPYQGTITEGTAKGKSAERKRKWDEWEEELLDDEVFAAKQARREAKKNKKSEKKSSISKEKRKALKQDVLKSVQTPLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZZ6</accession>
    <name>M2SZZ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_219901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701746.1">
        <property type="nucleotide sequence ID" value="XM_007703556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZZ6"/>
    <dbReference type="GeneID" id="19134565"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_219901"/>
    <dbReference type="eggNOG" id="ENOG502QTDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013895_0_1_1"/>
    <dbReference type="OMA" id="PTMMLKL"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="378"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="700" mass="76659" checksum="934B9E14B1C6835E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0X8</accession>
    <name>M2T0X8_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_37762</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700984.1">
        <property type="nucleotide sequence ID" value="XM_007702794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0X8"/>
    <dbReference type="STRING" id="665912.M2T0X8"/>
    <dbReference type="GeneID" id="19139078"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37762"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="737"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="554"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="824" mass="91268" checksum="64CA75BF442ED50A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0Z0</accession>
    <name>M2T0Z0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_33152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695467.1">
        <property type="nucleotide sequence ID" value="XM_007697277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0Z0"/>
    <dbReference type="STRING" id="665912.M2T0Z0"/>
    <dbReference type="GeneID" id="19137058"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33152"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034385_1_0_1"/>
    <dbReference type="OMA" id="KNWRYPG"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="80"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="479" mass="54217" checksum="57492BFF01AB607E" modified="2013-05-01" version="1">MSFSADKVSHLKGAFSQRRFSSSKDPTESELGSSIHRQFRQSHEGHKPHAGLDATRASTGVVWTSEQAYKHGFLEHPEEWANLGQGAPEVDDSIEGCFERPREVDISAHGREYGPTAGIRPLREAVATLYNEHHRKWRKSQYTWENVCIVPGGRAGLIRIAAVLGNCYLGFFIPDYTAYNEMLSLFRNIAAIPVPLGEADQYHMSPDKIAEEIARGTSVILTSNPRNPTGQMVTNPELAQIQNICRDRATLIMDEFYCGYNYTTNCDGTVISAADNVEDVDEDDVLIIDGLTKRFRLPGWRVAWVIGPKEFIQAIGSCGSYLDGGCNVPFQEAAVEMLSPPRVRNEMRALQMHFRTKRDYVIGRLQEIGFKFPYMPNSTFYLWLDLSNLPEGINDGLNFFQACLEEKVIVVPGIFFDLNPSRRRDLFDSPCHHFVRLSYGPRMDVLEKGLDSIQRIVTKYREQPQKHRAVSHRPRGTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1I2</accession>
    <name>M2T1I2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_92898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701193.1">
        <property type="nucleotide sequence ID" value="XM_007703003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1I2"/>
    <dbReference type="STRING" id="665912.M2T1I2"/>
    <dbReference type="GeneID" id="19141475"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92898"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2764685_0_0_1"/>
    <dbReference type="OMA" id="MNNSIFP"/>
    <dbReference type="OrthoDB" id="5599418at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8511" checksum="AA26A3063FF48ADA" modified="2013-05-01" version="1" fragment="single">DHEIILNKGAKLSPGLIYPIAPEHNAELRDYIQKNLKKGFIRPGSGPIASPILFVKKPNGKWRLYVDFRRLNSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1I7</accession>
    <name>M2T1I7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700989.1">
        <property type="nucleotide sequence ID" value="XM_007702799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1I7"/>
    <dbReference type="GeneID" id="19139083"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37772"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_1"/>
    <dbReference type="OMA" id="YPECLEY"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="85"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="327" mass="35404" checksum="C61CD738B7B04472" modified="2013-05-01" version="1">MGLNTDIDFVAAAAPVISAMVGAQKPALHDIESRRKWFSGLPIGPTAKGLVLEKHTIPASDGYELLIYHYKKEVTIDQASPAPVIFHIHGGGLISSSAANSIPMISECVLATGVQVFSVDYRLAPEHPYPTPLEDCWSGLRWVLSKAADFGLDTASIAVMGESAGGNLAAAVALLARDRGLSPPLAKQILIYPMLDDRNSSKGIGPVCIWNEVDNVTGWTAYLGHEPGRSGVPMFAAPARAENVEGLPPLYLDVGQLDLYMLEDLEYATRFVNAGIETELHVYPGLPHGFDFLAPGHPITKMAKENRYRTIRKLYRDSQVQSEAIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2G1</accession>
    <name>M2T2G1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_327307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700521.1">
        <property type="nucleotide sequence ID" value="XM_007702331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2G1"/>
    <dbReference type="STRING" id="665912.M2T2G1"/>
    <dbReference type="GeneID" id="19136886"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_327307"/>
    <dbReference type="eggNOG" id="KOG2767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_1_0_1"/>
    <dbReference type="OMA" id="YRYKMEK"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="252"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="415" mass="46354" checksum="A4045E7B74B6952C" modified="2013-05-01" version="1">MATVNIRRDVTDPFYRYKMERIQSKIEGKGNGIKTVIVNLTSVAGSLARPPAHVIKYFGFELGAQTNTSPNDDRWIINGAHDASKLQDYLDGFISKFVLCKKCKNPETDVHIKDGNITLDCKACGKISEVDPRLKLSSFILKNEPKKGKKDKSSKKAERRARKEAEARGEAGSPDNGSPGDSAEENGDDGDLALEAGSDDELTRQINEGAKEIEEEDAKEVEWSIDTSEAAIRARAQDLPDDLKRALVIEEDEEGGSNYDTFGKWIIDTGAEKGGVENLDNVDIYIKAKELGIETKHRTLTVIPQTLFTEKIVKQIDARAPMLKKMITSDKHEKAFLGGIERFVGIDKPELIPQVSAILLKVYENDLVSEEQLQTWCSKASKRYVDLKVSKTVRKSAEQFKNWLEQEESEEEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3K0</accession>
    <name>M2T3K0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_90691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700823.1">
        <property type="nucleotide sequence ID" value="XM_007702633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3K0"/>
    <dbReference type="SMR" id="M2T3K0"/>
    <dbReference type="STRING" id="665912.M2T3K0"/>
    <dbReference type="GeneID" id="19141361"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90691"/>
    <dbReference type="eggNOG" id="KOG0945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031126_1_1_1"/>
    <dbReference type="OMA" id="HRTCRIP"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD63816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="375" mass="42512" checksum="84B6342A9C0C1C4D" modified="2013-05-01" version="1">MVDQDDNGAAGSSFTCWLLDTRSIWPGTKITDSEAAREALSLVSLEERENITRKYHIADARMSLGSALLKRLFVHRMLGIPWKDIRFGRKRDPKHGKPIALLPPPQHGPAPLEFNISHQAGLVALVGCKTDELDAEVGVDIVCVNERDEYRVIDKEGFDGWIDMYAEIYSQEELFDLKYNVDSFPLLDGTMVTQEIIGRHDRCCARHKQLSITLPNGEKRVFDSELLIDAKLRRFYTFWCYKEAYIKLDGEALLAQWIPRLEFKNVRAPRAGTPARCSTHGTWGERISDAEVWFTMKADGKGPAGVKGMKRDESKRLDDTRVEIQAFDEKFMIGVAAKERTDAVVDGNRQKLPEVLTQFQALHLDEDIMSVARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3L1</accession>
    <name>M2T3L1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700456.1">
        <property type="nucleotide sequence ID" value="XM_007702266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3L1"/>
    <dbReference type="GeneID" id="19139016"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37584"/>
    <dbReference type="HOGENOM" id="CLU_584174_0_0_1"/>
    <dbReference type="OMA" id="TFEIDWQ"/>
    <dbReference type="OrthoDB" id="3660227at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="466" mass="53549" checksum="57FED9EBC403CB11" modified="2013-05-01" version="1">MATELAANPGFGALPNELVMSIIDCMPIENPKDILNLSLTSRRMYLLSLDHLYSHVLVSCPWPLTRTLLHDPKLAARVQQVTWNLSTGKDNSTENRKMLSRLMRSFEPVGVQPSIDHERLTATWRDHEFMAFFITVTPAIETLTIKETYGWRDNIYWFGKPVSEAGTLQNLRNVHIHGPLCLEQIAHLFRVPSLRNVTIVDIVQLERQTHDYVEWNDEIPLYTVLERGVSGVENIVLKRACVETKTLAHFTEACRQLKSFAYEHDIHNNLRSRRSPNLISKFESLTSVLTHNRASLERLSVRGDHHMLYQKHMLQLARLASRMSNLRSLDMGLIAHDDDPDQCTPEFVAELVRYLPPTLEELTFEIDWQEHWGSKGWEGPTEILRHLADIAPATLPLLKRVAVVDWPPKLGHFPPDFAMLYQCFAEHNIHFASIPVTIDAPDPIRISDCVEPGWIFVEVADVEWHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4E1</accession>
    <name>M2T4E1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_177087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694667.1">
        <property type="nucleotide sequence ID" value="XM_007696477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4E1"/>
    <dbReference type="STRING" id="665912.M2T4E1"/>
    <dbReference type="GeneID" id="19133065"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_177087"/>
    <dbReference type="eggNOG" id="KOG2368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_3_0_1"/>
    <dbReference type="OMA" id="VATAWDC"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="380" mass="40489" checksum="9A2073D27BF9626F" modified="2013-05-01" version="1">MSAKFLCLRSARLAARYPCHRRAFASAASSRADHVRIVEVGPRDGLQNEKQTVPLATKIDLVERLAKTGLTTIEAGSFVAPKWVPQMANSAEIFEHVLSHPPPSPQPITYQWLLPNVKGLDNFLSTWQSKSQPGQDAYSTPPPSPGPNDGSVSNASSQAEASSSPSSPRHEVSIFTAATESFSQKNTNCSIAESLKRFEPIMSKAKEMNLNVRAYISVALGCPYEGPNVDPHKVAELAVSLLEMGADEISVGDTTGMGTAPKTMELLKTLNAAGIDKNDLALHFHDTYGQALVNSVVALEHGIRTFDAAVGGLGGCPYSPGATGNVATEDLVHCLHSLGANTGVDIEKLAEVGQWISQELGRPNESRAGKATLAKLRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2T518</accession>
    <name>M2T518_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_32214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694232.1">
        <property type="nucleotide sequence ID" value="XM_007696042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T518"/>
    <dbReference type="GeneID" id="19136688"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32214"/>
    <dbReference type="HOGENOM" id="CLU_033666_7_3_1"/>
    <dbReference type="OMA" id="FERGFNP"/>
    <dbReference type="OrthoDB" id="4156902at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="94" mass="10520" checksum="2C62A49C4F2A5E80" modified="2013-05-01" version="1">MAPNTDSYTRVLIVTLKSPPVGKSTSQISELTGVHPRTIDRIYGRAIAAGFEPNVLPLKILPHHVQDAPRSGRPAKQTKEVKEQIFQQVRCDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5M9</accession>
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        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_171597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700289.1">
        <property type="nucleotide sequence ID" value="XM_007702099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5M9"/>
    <dbReference type="STRING" id="665912.M2T5M9"/>
    <dbReference type="GeneID" id="19132750"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_171597"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_14_1_1"/>
    <dbReference type="OMA" id="HANDSWA"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026257" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="553" mass="58465" checksum="F75B2F4ED493A8B8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6H2</accession>
    <name>M2T6H2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">COCSADRAFT_36212</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699121.1">
        <property type="nucleotide sequence ID" value="XM_007700931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6H2"/>
    <dbReference type="STRING" id="665912.M2T6H2"/>
    <dbReference type="GeneID" id="19138684"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36212"/>
    <dbReference type="eggNOG" id="KOG2958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_1"/>
    <dbReference type="OMA" id="CFENRGA"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
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    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="209"/>
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            <begin position="218"/>
            <end position="375"/>
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            <begin position="279"/>
            <end position="306"/>
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            <position position="199"/>
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            <begin position="28"/>
            <end position="31"/>
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            <name>UDP-alpha-D-glucose</name>
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            <position position="52"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <name>UDP-alpha-D-glucose</name>
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            <name>UDP-alpha-D-glucose</name>
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    <sequence length="411" mass="46444" checksum="438262C38525CCC0" modified="2013-05-01" version="1">MTDPVLNDISHRRFNLLRGSWILVSPHRTKRPWQGMQESPSKTTLPDYDPKCYLCPSNTRANGEHNPKFENTFVFVNDYSAVMEEQQEYRPDSKDGSLASRLLRAEAVTGKCYVICFSPSHNLTLADMSPAQIVPIIETWTNIYVAHLDSKSPLAKLASAINIPPLPQGPLTPPSAQYRYMQIFENKGTAMGCSNPHPHGQIWTTTSLPEEPATELVQLSKYRKENGGSHMLVDYAELESKEKARTVFENESFWAGVPYWAVWPFEIMIVSKQHKRSLVDFTKDERAQLAEAIAEITRRYDNLFETQFPYSMGLHQAPLTGTADEIECSHFHIHFYPPLLRSATVRKFQVGYEMMAEPQRDITPEQAAERLRSCDGELYRRRLEASPVTNGVNGVNGVNGVNGVNGINGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2T888</accession>
    <name>M2T888_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_159110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD65461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007700412.1"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_159110"/>
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    <dbReference type="OMA" id="YPVRPWE"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="223"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1379"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1381"/>
            <end position="1403"/>
        </location>
    </feature>
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            <begin position="1404"/>
            <end position="1415"/>
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        <location>
            <begin position="1416"/>
            <end position="1444"/>
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            <begin position="1458"/>
            <end position="1472"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1473"/>
            <end position="1486"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SMART" id="SM01281"/>
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        <source>
            <dbReference type="EMBL" id="EMD65461.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1557" mass="172277" checksum="45AD03672FE09FDF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8G2</accession>
    <name>M2T8G2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 78 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_356654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699702.1">
        <property type="nucleotide sequence ID" value="XM_007701512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8G2"/>
    <dbReference type="STRING" id="665912.M2T8G2"/>
    <dbReference type="GeneID" id="19138445"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_356654"/>
    <dbReference type="eggNOG" id="ENOG502QV6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007933_2_0_1"/>
    <dbReference type="OMA" id="WAPMANP"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026326" evidence="1">
        <location>
            <begin position="18"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="2">
        <location>
            <begin position="709"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="811" mass="87096" checksum="6B57FDD840FAA0F2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T912</accession>
    <name>M2T912_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_86479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698579.1">
        <property type="nucleotide sequence ID" value="XM_007700389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T912"/>
    <dbReference type="GeneID" id="19141114"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86479"/>
    <dbReference type="eggNOG" id="ENOG502QRRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024655_2_0_1"/>
    <dbReference type="OMA" id="KSCTACV"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD65427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="405" mass="45142" checksum="15641B8644A3D5DE" modified="2013-05-01" version="1">MLGYISSTRKKSCTACVKAKRRCDLGYPFCKRCFVKGLDCTYPNPRKTPVSVRDTEIVIRHTDTPPPRDTSQPATIASASAAANAATSVEPDCNFARDPWIVLRRDGESSESDEGSSLSSSPEVWMGHDNPLTARPPLRRTLLPTVVVPVLLNERQSTFVIEGLCSLVTSMACSGTTHFLHRNLFADHDQPVAYQDCVAISALYMAQNASYTGNILVNSINAKIAALVKEAPTWSLMQHLAAVQALIIYQIIRLFDPILGAQEQAVKHNVLLERWATSLFHRLCYDMPFFADERSRWVFTESLRRTLFMAVFTRCSWSVFTCGGLASQVHVLAGMPLTKDLGRWNQEENKALCQGESMQCQEQELISYVDMSVDWSHDKSVEELGSFGQLLLAPCRGRDDLRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9C6</accession>
    <name>M2T9C6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_114376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
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        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Aldolase class I"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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    <sequence length="313" mass="34478" checksum="47C3E992223060CB" modified="2013-05-01" version="1">MASSLNQLKATGTTVVCDSGDFVTIDRHKPQDATTNPSLILAASKKPEYAKLIDAAVTWGKTHGDDIDDQVDATLDCLLVQFGKEILNIVPGKVFTEVDARFSFDTEASVNKALRIIDLYKEQGIGKERVLIKIVSTWEGIKATEILQSMHGVNAIAAAEAGAFLISPFVGRILDWYKATNSKDYSNSEDPGVESVGKIFSYHKKFGYKTIVMGASFRSIGEITELAGCDYLTIAPILLEQLYNSTHSVPKKLDASSAKLLDMERKTYINDESAFRFCFNEDQMAVEKLREGISKFAADAVTLKEVLREKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697471.1">
        <property type="nucleotide sequence ID" value="XM_007699281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TA75"/>
    <dbReference type="GeneID" id="19137793"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34676"/>
    <dbReference type="eggNOG" id="ENOG502SPG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089692_0_0_1"/>
    <dbReference type="OMA" id="FHTNDED"/>
    <dbReference type="OrthoDB" id="8121437at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD66086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="273" mass="31440" checksum="5C809290A3D36817" modified="2013-05-01" version="1">MNYLCVPCNRSFSSSKAFEQHKKNSPVHKKTFCCETCNCPFKSEKALIRHRLKCKVDQEASLNQHPDEVALSTALARCSIPDTSALTFQNRAQTLVSANPVAITTTLPKIAKSNKLRLKQETREYFMFPELHSKIAEAVLLEIITTWFNNNDDDNFIYRYHTHIMGKFTCHNNKCGKKCWTSRKVPIEISGYDRNGYSAIVYNQRCKSCNCLGTFAIDEESYIKRVSYRIKKWAGVEVVQPDYEGKPTKPHERAYCEGCKRGKCTEDEDFWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2TA87</accession>
    <name>M2TA87_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_86158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698875.1">
        <property type="nucleotide sequence ID" value="XM_007700685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TA87"/>
    <dbReference type="GeneID" id="19141093"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86158"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075838_2_0_1"/>
    <dbReference type="OMA" id="AMCYQWK"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="187" mass="21592" checksum="588E2DC53ED365C9" modified="2013-05-01" version="1" fragment="single">SSYHELVQHHRSTLHRIICDGCDDGGWWIPDSQAYKEHLTDDNVCTVYERHFDSLNNLRHHKLVHLEPSIECYGCTRSFTTYSGMIIHLESGTCTSGIDTLDLNESAAMCYQWKKFLDEEYRDDILSCYDFEEEYFSAVYLFRCPECDTTFSKLSGLFQHVSSGSCEQKLNGGPIAKLVKWLSNRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBZ1</accession>
    <name>M2TBZ1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_301278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TBZ1"/>
    <dbReference type="GeneID" id="19136178"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_301278"/>
    <dbReference type="HOGENOM" id="CLU_2542425_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="83" mass="9744" checksum="DF5FC59EC7C52F5B" modified="2013-05-01" version="1">MTHKRSSFYLPFFLFIVATGIVNYIFSLDAEYAVDMYQVSSSTIARTKQYKFLFFSLVVISLFCFFYGLPHGVPAHFWRHCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2TC10</accession>
    <name>M2TC10_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_301569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698133.1">
        <property type="nucleotide sequence ID" value="XM_007699943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TC10"/>
    <dbReference type="GeneID" id="19136185"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_301569"/>
    <dbReference type="eggNOG" id="ENOG502TN0Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674400_0_0_1"/>
    <dbReference type="OMA" id="PAWWCKF"/>
    <dbReference type="OrthoDB" id="3944493at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="408" mass="45603" checksum="BCD4BB2D2934DAAB" modified="2013-05-01" version="1">MPSFSFWKSPKTEEPAHEPLLATHTTCDEVDIPDTIIPKNLDLDPGKEDSGVFLFDELDIQPPMCHPQVTTEVDGACTRETFVSPVPENTAERIDSPLEGLVEQSPLRSRVSEQCVFSETAPEYPPMVVMDVSTTTPKENNYNVEISKNDDHMPSSQPTASTPSMSPKQTAPAKPATHQRKTSIARLRRPAELNLATNTTSSSPSQPCSELEQRYALIRNSKTQSKAALRSPTALLEERLNLTPKKTPGSENKVRIFTPPQTPEDGCWIPGPGVATNAFTSSSIRACTEKTGRPAWWCKFDKLVVFDGIDHDASGEMTIRTRTSKGLSVARRRGDLESIVIPLDCSHCQEMLNRHEWKYDMRICKRSVCWDCKERCKWEAEEEKRAKSVQKSGKAEGNRFRADSVLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2TC41</accession>
    <name>M2TC41_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_112791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697900.1">
        <property type="nucleotide sequence ID" value="XM_007699710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TC41"/>
    <dbReference type="STRING" id="665912.M2TC41"/>
    <dbReference type="GeneID" id="19130194"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_112791"/>
    <dbReference type="eggNOG" id="ENOG502S3Z0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_5_2_1"/>
    <dbReference type="OMA" id="YGPFRSH"/>
    <dbReference type="OrthoDB" id="3679575at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="5">
        <location>
            <begin position="66"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD66397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="305" mass="34228" checksum="3ACE76C2A810DE53" modified="2013-05-01" version="1" fragment="single">MAPICPPPPPPPPPPPPLYGAPFPEKPAMPVIFDTDLTTVVDMTKAKNIAVHKIDKSIWHLQDSDRILKRGPNVKVTEAEALRFIASSTHVPVPEVFGAYEKDGFGNIFMSRVIGTPLHDVLHTFHEAQVERVTTQLSGFVQSWMGLRGDFFGSMGFKPCQDVFFQHLPAANMPDRKYGPFRSHTEYCNGLIDALRNSRPYGRFDANDAHLIERIQRLGDKCAVFCHGDLTPDNILVDDQLNVVAILDMGVSGFSIPEREYFEAKSRARNSLWSSMIDQIIPKIPDNTYALLLELERELVRYSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TE57</accession>
    <name>M2TE57_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_34314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696590.1">
        <property type="nucleotide sequence ID" value="XM_007698400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TE57"/>
    <dbReference type="STRING" id="665912.M2TE57"/>
    <dbReference type="GeneID" id="19137583"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34314"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049943_1_0_1"/>
    <dbReference type="OMA" id="HVCVCNL"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000228">
        <property type="entry name" value="Galactinol synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
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        </location>
    </feature>
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            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="422" mass="47961" checksum="30BA29D4E6CE253D" modified="2013-05-01" version="1">MADKSRHGSPPSKNAYATLLTRPSYLAGAILLAYTLHKHSPSTPLIICYTPDTLPESSVTAFAAEAKHSNIILQPVEHLRLPEDGTAHGMVAERFIDTWTKLRVFDLWEMPQKWERLCWLDADMMIFSDPSPLVFNAQNDEYLTGGDGIRTMAVHTCVCNLDHDVWAPAEWTKENCAMTPLSSPDQLAEVKSEPYTLSNFNSGTFLYRPSKQLADFVKQKFEELGNARLRAMKFPDQDFLNEAFDRRWSPLSWRTNALKTWRYWHRNIWTDDSYVAVLHYIVDKPWAARNNPDGSAGYLGKDGETHKWWWDEFEVWRREREEQGEKELLGVVEKYVASKDGAVNEEMKAIGGGAQDFAKKWDKKEKEDEKENEGRGGKEGGGLKLSDDAQKKADDYGQGSHGPILRKPMLGERGHGPVVHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19130987"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_135820"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67147.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="121" mass="12617" checksum="439D22EE769A37A4" modified="2013-05-01" version="1">MSSLTAQESSNTQHQNPINPGDDTCGTFKGDPSVPFKTGGSTDPAGLSTSVDKSSYGQQNASDTSEQRRGEDVTQNTKQEYEGSSNVGVKTGSESLLDSVERSVKGDRSGVDVGQVTGGRK</sequence>
</entry>
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    <protein>
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    </protein>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699222.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2TF48"/>
    <dbReference type="GeneID" id="19131044"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137288"/>
    <dbReference type="eggNOG" id="ENOG502RXR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="RLPWEWY"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="103"/>
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            <end position="131"/>
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        <location>
            <begin position="405"/>
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    </feature>
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            <end position="342"/>
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        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="454" mass="49928" checksum="049E6D663B408289" modified="2013-05-01" version="1">MDGAPESHAISPQLRQRMLNRAATFGEGVQPSTPPAAVSRRRSSLVSNLSDTRPSLWSSTDNLLRAGVKYDMDRQDAASDEPSRWIALPVVAAVVPAIIGLTVENGAVIATDVLILVLAGWFLHLSVKVPWDCYHDAQQRRYISDEADDDTYDDTIHEVNENDVHGIAEGAGDAASQEQVDMSPALSVTSSAQQEAREALKRSELLAFVGCFLGPLLGALLMHTVRGQLMRAEGIVSDANLSIFLLIAEIPPVNRLIKMRTERILHLQRIVRDAPRGAVRPVDAQQLSQRMAELESRLDGASSSNNKNTSQIDVEKLSTEIRQTTQLQLDALNRAVRRYEKRHMAQSIQIEARFQDLEARLQDTLALAAAAARTGHRPGIVTVTLSWIAGTISSMLQLVWDISMYPFRTAAIILSVIKSMFVPDKRQIKPRTKGGQVNGHTSIPSSRMQSKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF61</accession>
    <name>M2TF61_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_294188</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TF61"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_294188"/>
    <dbReference type="eggNOG" id="ENOG502T17J">
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    </dbReference>
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    <dbReference type="OMA" id="PMANAWI"/>
    <dbReference type="OrthoDB" id="2355426at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026708" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10216" checksum="06E4D62704EBFF76" modified="2013-05-01" version="1">MKLNTIMLLPAFATAIHAWTLVLGGQVFDGKGNRGCSRVTANAGSRLDWDRAILSSCCVHLYSDAGCSKQNGYSCSDWEKNLGQNVRAFKVTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF68</accession>
    <name>M2TF68_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_157782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697060.1">
        <property type="nucleotide sequence ID" value="XM_007698870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TF68"/>
    <dbReference type="STRING" id="665912.M2TF68"/>
    <dbReference type="GeneID" id="19131851"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157782"/>
    <dbReference type="eggNOG" id="ENOG502RZVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079143_2_0_1"/>
    <dbReference type="OMA" id="DINFTHG"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="36"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="226" mass="26252" checksum="EC47A583457C2BED" modified="2013-05-01" version="1">MAQDQSRGEETTGLSEWKQRPPYRIHEKNEDFDVKYEANCHCGKVKYQLNRREPLDSKLCHCTTCQTQHAAPFQWAAIFHKTDINFTHGHHNLEWYDPTEKSIEHKLPCKVRCSYCHSPIMDEGRNMILLFPSLVHLKTDEDKAYFKPRCHMFYGQRVMDVPDGLPKWSGLSGESDLIEDSPPDLVRETERKREEERNKKMSEGKPDEVTKEGTQGRKEGTGSNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFE5</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_34262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696577.1">
        <property type="nucleotide sequence ID" value="XM_007698387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFE5"/>
    <dbReference type="GeneID" id="19137555"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34262"/>
    <dbReference type="HOGENOM" id="CLU_112522_0_0_1"/>
    <dbReference type="OMA" id="GRCQHFE"/>
    <dbReference type="OrthoDB" id="3679329at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="217" mass="23570" checksum="4A53A2B2D05DDEDD" modified="2013-05-01" version="1">MRASIATIATLTSQIVHAQSGMNMFPGSMVSGSMLTCQSGYVPSLTCENPVPETCACTCSDGMTFNQSRPPVVDPAPPPVEPPHQLVEKPCTTEIIQPWREITLPHVKNSYEPSEMFEHEVEVAEGSVFVVADSVGRCQHFEVFVDGVSVGETDGTGELDGFHCGTPENCMENHGGSKGYFTLPGGKHTIGLKWIRISDKCKHIKEGYGSYQIYKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2TH53</accession>
    <name>M2TH53_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_156513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695760.1">
        <property type="nucleotide sequence ID" value="XM_007697570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TH53"/>
    <dbReference type="STRING" id="665912.M2TH53"/>
    <dbReference type="GeneID" id="19131768"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156513"/>
    <dbReference type="HOGENOM" id="CLU_438033_0_0_1"/>
    <dbReference type="OMA" id="PEIGQSN"/>
    <dbReference type="OrthoDB" id="3693399at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="624" mass="69341" checksum="65397916E150649F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ12</accession>
    <name>M2TJ12_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_105425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694594.1">
        <property type="nucleotide sequence ID" value="XM_007696404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ12"/>
    <dbReference type="STRING" id="665912.M2TJ12"/>
    <dbReference type="GeneID" id="19129971"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_105425"/>
    <dbReference type="eggNOG" id="KOG0529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031996_2_0_1"/>
    <dbReference type="OMA" id="RKFPKCY"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="359" mass="41753" checksum="F78001175BCD3A4C" modified="2013-05-01" version="1">MASHGIARGTGPVVRSEEARQKELEQIAQYKELADLVNTKIAEKQHTIEALGLVTKLLNENPEYYTIWNHRRRVLVALVKAESPGQSPHDLLQDDLQLTFALLRKFPKCYWIWNHRNWLLRQGEALMGVEAAHKLWSGELQLINKMLHADSRNFHAWGYRRIVVSEIERLAADSEPTTENTPKSLAESEFEYTTKMIKTNLSNFSAWHNRSQLIPKILLQRNADSKARRAFLNSELSLICEAINTDPFDQSIWFYHQYLLSVLSPSCPPNHQVVQDLTNDERQKYYENEMEYIREILEDEADCKWIYEALLGLAEAYLEVDAGTGTFTTKGMKSWLGELKRLDPLRRGRWDDLERRLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2QS79</accession>
    <name>M2QS79_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_47231</name>
        <name evidence="4" type="ORF">COCSADRAFT_69876</name>
        <name evidence="3" type="ORF">COCSADRAFT_72098</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr</strain>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445789">
        <property type="protein sequence ID" value="EMD58044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KB445770">
        <property type="protein sequence ID" value="EMD58063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KB445696">
        <property type="protein sequence ID" value="EMD58144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706155.1">
        <property type="nucleotide sequence ID" value="XM_007707965.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706237.1">
        <property type="nucleotide sequence ID" value="XM_007708047.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706256.1">
        <property type="nucleotide sequence ID" value="XM_007708066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QS79"/>
    <dbReference type="STRING" id="665912.M2QS79"/>
    <dbReference type="GeneID" id="19140228"/>
    <dbReference type="GeneID" id="19140460"/>
    <dbReference type="GeneID" id="19140488"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_47231"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_69876"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_72098"/>
    <dbReference type="HOGENOM" id="CLU_206083_0_0_1"/>
    <dbReference type="OrthoDB" id="3686619at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="52" mass="6090" checksum="67C84F93CC44270D" modified="2013-05-01" version="1" fragment="single">MATPNEKPLKKPKMATPEKYDGSRTELRTFLTNIDLYCEFNEVPNDQEKILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2QUZ5</accession>
    <name>M2QUZ5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_165202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705413.1">
        <property type="nucleotide sequence ID" value="XM_007707223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QUZ5"/>
    <dbReference type="STRING" id="665912.M2QUZ5"/>
    <dbReference type="GeneID" id="19132367"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_165202"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_3_1_1"/>
    <dbReference type="OMA" id="IHHAAIM"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000291">
        <property type="entry name" value="APSES transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="502"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD58959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="692" mass="77419" checksum="99AEBA43858C2113" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2QVM6</accession>
    <name>M2QVM6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_152571</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704936.1">
        <property type="nucleotide sequence ID" value="XM_007706746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QVM6"/>
    <dbReference type="STRING" id="665912.M2QVM6"/>
    <dbReference type="GeneID" id="19131595"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_152571"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="OMA" id="FNWYNTT"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023484" description="Mannosyl-oligosaccharide glucosidase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="17">
        <location>
            <begin position="39"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="16">
        <location>
            <begin position="303"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD59144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="812" mass="93027" checksum="5F9702E16ED55C33" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2QYV6</accession>
    <name>M2QYV6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_249958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704391.1">
        <property type="nucleotide sequence ID" value="XM_007706201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QYV6"/>
    <dbReference type="GeneID" id="19135191"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_249958"/>
    <dbReference type="HOGENOM" id="CLU_148143_0_0_1"/>
    <dbReference type="OMA" id="TWPTEYK"/>
    <dbReference type="OrthoDB" id="10423392at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="147" mass="16014" checksum="943E1A185E693599" modified="2013-05-01" version="1">MHPLTRRTLADVTTPTRQEPPAAAVAPCASIVSAFRACHARLHATCIQIHATPRASPRPSANHHRPPPNHCSHPARLPTCTPPTTANHPHSTYAQFLRPPASPLCLLASCKLVPLVRGYSARKNPSSTSTWPTEYKRLHLTASSPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZJ4</accession>
    <name>M2QZJ4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_40132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703623.1">
        <property type="nucleotide sequence ID" value="XM_007705433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZJ4"/>
    <dbReference type="STRING" id="665912.M2QZJ4"/>
    <dbReference type="GeneID" id="19139656"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40132"/>
    <dbReference type="eggNOG" id="ENOG502RXXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077738_1_1_1"/>
    <dbReference type="OMA" id="FQGPIAC"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000048">
        <property type="entry name" value="Free methionine-R-sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="61"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="175" mass="18960" checksum="488736FF2E94CB0B" modified="2013-05-01" version="1">MVHADSSTFAHGMSKKEVYGQVLEQARALFDGQRNWVCNFSNAASLLWHAYHSLPAPSSAVNWAGFYFTDRSNPSHLLLGPFQGQVACQVIAFGRGVCGKAAKEAKTQLVDDVEKFPGHIACDGASRSEIVVPIVKDGKVVAIIDIDCAELNGFTTQDQEALEELAQLLAESCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZR3</accession>
    <name>M2QZR3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_98539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703884.1">
        <property type="nucleotide sequence ID" value="XM_007705694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZR3"/>
    <dbReference type="STRING" id="665912.M2QZR3"/>
    <dbReference type="GeneID" id="19141800"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_98539"/>
    <dbReference type="eggNOG" id="ENOG502SSCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099931_0_0_1"/>
    <dbReference type="OMA" id="QEWTMEF"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="164" mass="18574" checksum="B54DB8EEC5557051" modified="2013-05-01" version="1">MYTRTVFLIVYAAARVQRAHFSIWVPDAEGAQQGSRIHVVGNPMIGYFLEFKRDYEPLETKRVLQLIEIGPVLVQHLSEISSEAQDMPRNNLEMAATQIQPPRANPNFLTVSTTSSDSQTWMLEYVRHLVTLGYLDEAAIDIVQSNQDPPQVGIRLRPTAARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2R1K3</accession>
    <name>M2R1K3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_163504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703442.1">
        <property type="nucleotide sequence ID" value="XM_007705252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R1K3"/>
    <dbReference type="GeneID" id="19132250"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163504"/>
    <dbReference type="HOGENOM" id="CLU_130501_0_0_1"/>
    <dbReference type="OMA" id="QNTHIKQ"/>
    <dbReference type="OrthoDB" id="10389213at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="158" mass="17642" checksum="60BB10A8925305B2" modified="2013-05-01" version="1">MAPRKTKKAAKTKRTPSQVKRNTRSHQTRTSPQESPSQNIYIKQEESDETLLTTPGHTTHAHLTPTHKSSSTTYKIKKSTSYPKTPLNAVQSIAMTRCRNSIRRAEFREYVRLGITPLEGKGSGIVQGGQGMTNPLVDEGGEEEIPIIQENSRNELEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2R2J6</accession>
    <name>M2R2J6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_123124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702797.1">
        <property type="nucleotide sequence ID" value="XM_007704607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R2J6"/>
    <dbReference type="GeneID" id="19130546"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_123124"/>
    <dbReference type="eggNOG" id="ENOG502S837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573828_0_0_1"/>
    <dbReference type="OMA" id="EIHNYTY"/>
    <dbReference type="OrthoDB" id="5325276at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="441" mass="49413" checksum="18203867D1BC1DE1" modified="2013-05-01" version="1">MKEKIKAVLHRRKGSTPAQSPRASYEQSEGVIPRAEQLPSSPSQRHRPKSSASQSASLRTEYAQQPKTTHTNGIATHSAALPLESVHNTQSDHSKFVNSASDGNTPVPPAPAPSKQSIVAGTNIGHSAPSHSDLSKPLPAIPNSTSYNHGDARDKLVGRAVTTNGGIVEEAQSHDPKDLARSSQSLEREHHVHQDMAVKPAGFDSTSDRHSVYGSDEEWQVKQKSMLNGIVNLNDTVETDRETSWAPAVTHEVIKRHEHEIVQHKIYREIHNYTYYHRLQPVMQTEVLPPRHFIPNPDGEGLIEISADELPSRTGKNRWWDIVQKEPVLTKAPFQWRTEPQIIEGKPYMTDEGFERRETTIIYPPTLEDMSDYDGIVQPVHFDHKTGKRWLGELTTIDKLQRQVDGASEDDFMMMKNITADLPEIPNSPSVKRRLVGRDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2R6C2</accession>
    <name>M2R6C2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_201285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701997.1">
        <property type="nucleotide sequence ID" value="XM_007703807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R6C2"/>
    <dbReference type="STRING" id="665912.M2R6C2"/>
    <dbReference type="GeneID" id="19134186"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_201285"/>
    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_3_0_1"/>
    <dbReference type="OMA" id="RYQNWDW"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="100"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="451" mass="50881" checksum="1C7A6D2E6161ED4F" modified="2013-05-01" version="1">MAPSRGCAISYAQRIFSGYVIRPHRNFFSLSVDRASRNPISQTRLFRLSHHRLSSFQQCSYLTFTDTLADPANKLQSYVSTSSDPYCNLSIEDHILRKSPPDSTILFLYVNRPCIVIGRNQNPWSEVNLGILDAARGTHDPKDTEPPGIGTVDLVRRRSGGGTVFHDEGNLNWSITCPRADFTRDKHAEMVVRALRKLGVQRARVNERHDIVLDQGQGNDGQPFDPEDTHRTPYTIQNRALPRPLKVSGSAYKLTRQRALHHATTLLSSPNLHIIPHYLRSPAKSVIRAQGVESVSSPVSNIGLDVKTFQLRLQEEFSLMYAGLGPPSTIQTVGDEFLDIPDIRKGYNELQSEEWMWSQTPAFSLILDPKDDIGVEIKVHHGVIKSLDFPNSSLSHENRSALDTALVGLELHKIQDWTAFLQKCIHSWDNELATIARRLDELLPIPRMFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2R6G1</accession>
    <name>M2R6G1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_93576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702025.1">
        <property type="nucleotide sequence ID" value="XM_007703835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R6G1"/>
    <dbReference type="GeneID" id="19141511"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_93576"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="OMA" id="KIAWGIS"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="69"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD62729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="489" mass="53033" checksum="4191FF46C2274763" modified="2013-05-01" version="1">MANLKVPASAHRLSFNRTAAQTVKQTTVVQEHSLLEPLSPLPDIERHSTPAAEDDVFGNEEGAEIQYKTCSWWNTGILMLAENVSLGVLALPQALAILGIVPGMLCICLMGIIATYTGYLIGEFKLAHPSVQSYADCGQLMSGLIAREVIAVAQVLVLIFIMGAHILTFAVAMNAMTNHGACTIIFSVVGLFVSFLLGLPRTFKNISYFSIFSCVSIIVGVTITMIAISIQKPDMNNMVVIRPDVPLVKGLAPVMNIVLAYTGHVAFFSFASELKDPRDFRKALFFEQGIAVTFYLLISAVIYYYAGPLVSSPALGSASPLVSKICFGIALPTIIVAGVVNGSVATKYVYLRVWKGTNEVHTNSWRSLGSWVGICSGAWLASWILAEAIPNFNLLLGLIGALFGSWFSYAFPPLLWLWHNKVNGRLFFSKRQMVFTVLNFSIVLLGMAIFGLGMWSSGWALHDGSGGKVFSCEDNWHPVSWVAGGTDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2R9V3</accession>
    <name>M2R9V3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_330127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000016934">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="51"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="89" mass="10056" checksum="F9C18EFC725AE579" modified="2013-05-01" version="1">MACREKNRNLPGFECQVSVTRRVVYCVLHKAKGMTNDLKLARYAMAPRRTTHSYVILAILVLLAILPILRRNACACHGYAALEIQGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="RQQEGPY"/>
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            <end position="85"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="111" mass="12881" checksum="3F862F1147AC4CEC" modified="2013-05-01" version="1">MRIHSVFHKKLLEPAPLDAELATDIELEDDEYEVEEIKDLRKISNQPMVRIAVVRQQEGPYQGQSSPQPALSPDPKDSRWQDPDQQTLALVPWSLEARDEDEKFLQPHERP</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_313317"/>
    <dbReference type="eggNOG" id="ENOG502S13F">
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    <dbReference type="OrthoDB" id="5422068at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
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        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
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        <location>
            <begin position="8"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD64674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="371" mass="41190" checksum="BA9F547C2C1E3522" modified="2013-05-01" version="1">MTDDTITLTASCLCKAHVHTTTIPKFSLPLKAHICHCDTCRHVSGSLYSSLAFWPSPRSTVDLSGYKFFNFSPAFDLLFCATCSTPMIGAFKDETKPLLMVTGALNNFACDVEVVKWSHMGFIGDTRDGGASVWMKYINASGPPLKCFKTETRGDGVEELADDWQLQLESPDTTTEQQDAIPIRCKCRGVDLVLNRGNYDHVATEHLPWNVDPTSRKLKAELCSCDSCRLHTGNDVFYWTFADLRHISFPISSDENGFPSNMQDLAALVDSKDARIGSLVYYESSPGVHRYFCNTCSTTIFYTVSTRPRFVDVAVGTLEAKDGARAESILAWQFDYGVGHKEDGAGGWREGLFERIEKSLKEYGHTRSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2RDF0</accession>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <reaction evidence="12">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
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        </reaction>
    </comment>
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            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
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    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
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        <property type="entry name" value="DHODEHASE_1"/>
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        <location>
            <begin position="419"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="EMD64849.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="352" mass="38983" checksum="CB3E38FA28CC005F" modified="2013-05-01" version="1">MCQWYSLFNGCTMIFDWLDDAAEETKMFLSILMYEQVPFELPRKLWIVHHTALLPYTVRIHPFTSLTPHSCAYEYGGRESPNALVYIGGLTSGPQTSSLVLKIDSAMENMTETDTLSYSVFEFRMRSSYTGFGYSSLKNDVEDLAALVRYLKGESVGKEKVVLMGSSTGCQAIMTYATTLPASPPVNGYILQAPTSDRETASLLMPPKFLHTSLQHAEDLIAEGKEMQIMPSDLIPPIFSSPISAYRWHSLVSVGGDDDFFSSDLPASTHESSFGRLGKPTLIIVSGKDEIVPPNVDKEALLKKWVDAMPMGLASDQSGVLPDADHELTTDGRTRSFMDKACRFLKDLEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2RHU0</accession>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <lineage>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10071381at2759"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
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        <property type="entry name" value="Rad21/Rec8_C_eu"/>
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        <property type="entry name" value="ScpA-like_C"/>
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        <property type="entry name" value="FI11703P"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04825"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66504.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_354175"/>
    <dbReference type="HOGENOM" id="CLU_083651_0_0_1"/>
    <dbReference type="OrthoDB" id="10393613at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="209" mass="22517" checksum="96F15E69B6D8220B" modified="2013-05-01" version="1">MEDARYSVFACSRTDPLASALYGARVERGRGAAGMDMRRGCQSPPATSGSPVEPLSGSGRSRLATTAPCSSWGATRPRDWSALGFTGLAYCSRPLHLLFDGLNKVQQIDNSQSLTTAPALARCASPLRRDKLVRQRRPRSTRSIITAAKKACGHLAAAPAAEPLVTKPLHDPPDVLYMLYMHRLGVPPQLQGVLQLGAMSLRLRLLPLC</sequence>
</entry>
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    <accession>M2RJE5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_158899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698217.1">
        <property type="nucleotide sequence ID" value="XM_007700027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RJE5"/>
    <dbReference type="GeneID" id="19131927"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_158899"/>
    <dbReference type="HOGENOM" id="CLU_1396189_0_0_1"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="195" mass="21042" checksum="2691636BC0ED3786" modified="2013-05-01" version="1">MSIVVRTTADALFNVLGVPFAEIKASGMLTKNGILIWGGGNAVGWAAIQLAKAAGISPTISTASSSHHQILRDLGSTNCFDYRDDDVVTKIQIAIDQSGQPLKLIFYSVCTNGQAPSTSRFDAINTASGAIFTGTLLVLSDKNKRIWCLAAQVWDLNLPPPIGSISANKEWELRLIETVSWATENYGKGFRRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RKB5</accession>
    <name>M2RKB5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_48693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698475.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2RKB5"/>
    <dbReference type="GeneID" id="19140247"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_48693"/>
    <dbReference type="HOGENOM" id="CLU_004184_6_0_1"/>
    <dbReference type="OMA" id="CTFEVTR"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="33"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="176" mass="20364" checksum="BD96551B88EBBA45" modified="2013-05-01" version="1" fragment="single">IRLLELLPKTQWRNNCQPACRLFHTSLDKHPPYLALSYVWGDKSDPRRILVDGCTFEVTRNLFEALSGIVESESFIIWIDAICINQVDDEEKGWQVALMGDIYRQTSEVIAWLGPSAHNSDAVLEHLDILGSISESLGLPTDTSLCLTAWKSHRYLLRLSDLDHLFRRQWWSRIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2RLF9</accession>
    <name>M2RLF9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_34276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RLF9"/>
    <dbReference type="STRING" id="665912.M2RLF9"/>
    <dbReference type="GeneID" id="19137562"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34276"/>
    <dbReference type="eggNOG" id="ENOG502SXHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023876_0_0_1"/>
    <dbReference type="OMA" id="RYEIRIW"/>
    <dbReference type="OrthoDB" id="5213630at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="483" mass="54776" checksum="CADC2CBE7D5E7216" modified="2013-05-01" version="1">MATLSPDVRDSTLKSLKLTCPSAEVIHPPSSQSQSSDDMPPTEQQGYPFPEVGDEWSDEEVLIPRQRRKTQYIPPSMFEKITATSAESSSEDSSTPSPRPQRSGGKVSPNVPLKSPSRQSASRGNSQDELVQRFYQLTKERDALRKELQRKSMGANGTSTRGSKLYRTEEDTLIEELFALRHEIRNWSEEYFSGPIKTSSKRPYLTRAGELFGNLTDNYHVYLKDPEDRPLLIQAYVWMRLQQKIFNNWQKGSGYVWAGKLGDKKLRDINDTLRKAVKNEAEAEEYHRWRSLTVNLLVPQVDGKWRPTFDATPVLKQISRFCSRMRHKLRPWATRSLSTGKEQLGTIVSASVALDLKMKRQRADYRFVTFTGGKKDQYWGYGYYDSEMEDVYDDDSDDMGGGYGSSDNPRGRRVELALAPALERCGNANGHVFDQSFMLVKADVSCKRLEKRRKPQPRPRGGGGGSVAGGRGANNRFSGFWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2RLJ5</accession>
    <name>M2RLJ5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_34309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696589.1">
        <property type="nucleotide sequence ID" value="XM_007698399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RLJ5"/>
    <dbReference type="STRING" id="665912.M2RLJ5"/>
    <dbReference type="GeneID" id="19137582"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34309"/>
    <dbReference type="eggNOG" id="KOG3624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_4_3_1"/>
    <dbReference type="OMA" id="FGWAQVW"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="89"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="548"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="83713" checksum="EB075665E44EB92B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2RLT9</accession>
    <name>M2RLT9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_290612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697200.1">
        <property type="nucleotide sequence ID" value="XM_007699010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RLT9"/>
    <dbReference type="GeneID" id="19135988"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_290612"/>
    <dbReference type="HOGENOM" id="CLU_2589588_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="80" mass="9341" checksum="0C6482F44FDBE8BC" modified="2013-05-01" version="1">MFAYFNLAYRFLYIFSFFLPFPILRSCVRVASIYYCSFFVVVPPIPKLAYLLLLLPTVAFVDLRMSLSFSTPFFICLPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RP06</accession>
    <name>M2RP06_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_134024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695989.1">
        <property type="nucleotide sequence ID" value="XM_007697799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RP06"/>
    <dbReference type="STRING" id="665912.M2RP06"/>
    <dbReference type="GeneID" id="19130914"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134024"/>
    <dbReference type="eggNOG" id="ENOG502SH94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_3_2_1"/>
    <dbReference type="OMA" id="ATLWPQV"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140160" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD68364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="523" mass="57243" checksum="30141C12A01A5907" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRP0</accession>
    <name>M2RRP0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">geranylgeranyl diphosphate synthase</fullName>
            <ecNumber evidence="1">2.5.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_21474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694060.1">
        <property type="nucleotide sequence ID" value="XM_007695870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RRP0"/>
    <dbReference type="STRING" id="665912.M2RRP0"/>
    <dbReference type="GeneID" id="19134471"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_21474"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650545_0_0_1"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="422" mass="47948" checksum="FB93ED5FC62AB9AC" modified="2013-05-01" version="1">MYMRLDITLERRHRNFTRTIPHKGVRQHNEGRQTAFAGTTLCEDIAGMLKPAQDPMKQDWIGSSMSGLLSSLGDPINGNFSALALPPTKPKCMRLVAYLLEYIFLHDSVIELEQPGMRKQYGTLDECLDFRLIDAGTSVIEALLLLGMGVTLTEEEDAQLEPIRKPGFIALALADDYLSFDREYLEFSDPRYHPEPRYDPNAGLEDELTARSMPEALGINYEARFIHNRLHSALLILDDVEDGSTLRRGDPAAHPVFGVAQTINSGCYELVRAVEEARQLGPDAIEIVLEGLDELHVGQSYDLYWKQNNLCPSDNEYLEVYQIRDYKNLGSKDYTEKKRFCQDLDEGKFSFPLMHASNVQSEITQLLCELLQRRSDAGHLSYEQKKLILKQLDRTGSEVYKGVKKIEGAMKIENWVLRALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRX4</accession>
    <name>M2RRX4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_208934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694686.1">
        <property type="nucleotide sequence ID" value="XM_007696496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RRX4"/>
    <dbReference type="STRING" id="665912.M2RRX4"/>
    <dbReference type="GeneID" id="19134365"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_208934"/>
    <dbReference type="eggNOG" id="ENOG502S7PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052690_0_0_1"/>
    <dbReference type="OMA" id="SNLRTWA"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="307" mass="34072" checksum="4D2FFC7EAF0159B9" modified="2013-05-01" version="1">MLPPVDPAVLQRNPNFEILYKDLCTRKLNPNGSTRETKKQRVHDEIRRALSAARTSLLTTQILIDTLSDLPSKAADLPPELHSVIDIATAQLRGQIPSSDREILSADLEAFLTNSDIISDALSTQLSKTTTHLCKIADPLNPPSPSDLSARTNALQTEATLTLPDELQSAHLHLTHSFTVLLATHSTLLTTAIKILEQTQQGALARHTRSSADLLHARSVLLGLQAKIHTYSHPPPAEFVDALRQFKKSQGSGEKALRDREALARRELELYEHAGEKGMKELARRKEWILAEVQRVEEEVRKLERGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSX6</accession>
    <name>M2RSX6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_41998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445657">
        <property type="protein sequence ID" value="EMD58333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705961.1">
        <property type="nucleotide sequence ID" value="XM_007707771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSX6"/>
    <dbReference type="STRING" id="665912.M2RSX6"/>
    <dbReference type="GeneID" id="19140136"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41998"/>
    <dbReference type="eggNOG" id="ENOG502RI6K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406557_0_0_1"/>
    <dbReference type="OMA" id="QSAPTWE"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:1990904">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="618" mass="69381" checksum="6EF3A0548ED1664B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RU09</accession>
    <name>M2RU09_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_154326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705736.1">
        <property type="nucleotide sequence ID" value="XM_007707546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RU09"/>
    <dbReference type="STRING" id="665912.M2RU09"/>
    <dbReference type="GeneID" id="19131663"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_154326"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="OMA" id="YQNFPKT"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54055" checksum="F8BCFFD3520BCA53" modified="2013-05-01" version="1">MAPALLLDESSSPCTVSVTSASPSTDNCTPVMAASWNRQNRRSPLLKRSVRSVPLWLTSAKGSWLSVTDGTKTWKLFDASGGAGVSNIGHGDRRVHEAIKRQEETGVAYAASMSFDTEAAWEFADYLVESTGDEMAEVAFYSSGSEATEAAKKLAYQYHSKLKQKGQPGRRWFIARDRSYHGATLGALEVSGHKGRKGMYKQILPDNTQFVSPCNPYRDMKDGETADEYVKRLAEELENKICELGAGTVAGFFMEPVVGAALGCVPALPGYLTAMKKVCKKYNILFILDEVMCGMGRTGYLHAWQEEGVVPDIQLVGKALAGGYAAVSALLVSADIVETLGVSCFAHGHTFQNFPAACAAGLAVQKIVHQDHLVENVKDKGDKLMKKLVARLGDHPNVGNIRGAGLFRGIEFVRDKKSKTPFDSEAAIAWRIHEQGLRDGYNVYVYPGSGTVDGERGDHIIIAPPFNITDSDVDTIVESVSKLIFDFFEDINSPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUE0</accession>
    <name>M2RUE0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_78536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695305.1">
        <property type="nucleotide sequence ID" value="XM_007697115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUE0"/>
    <dbReference type="STRING" id="665912.M2RUE0"/>
    <dbReference type="GeneID" id="19140668"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_78536"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_3_1_1"/>
    <dbReference type="OMA" id="PQCGSPF"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024397" evidence="4">
        <location>
            <begin position="19"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="7">
        <location>
            <begin position="118"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="232"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="361"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD70189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="658" mass="73958" checksum="595C124F77A3F926" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RYX5</accession>
    <name>M2RYX5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_346797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704407.1">
        <property type="nucleotide sequence ID" value="XM_007706217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RYX5"/>
    <dbReference type="STRING" id="665912.M2RYX5"/>
    <dbReference type="GeneID" id="19137797"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_346797"/>
    <dbReference type="eggNOG" id="KOG2254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005482_2_1_1"/>
    <dbReference type="OMA" id="YIQMIHA"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="10">
        <location>
            <begin position="74"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="11">
        <location>
            <begin position="410"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD60223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="687" mass="78098" checksum="6D210AFB4118A45D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2S1I2</accession>
    <name>M2S1I2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_39797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703109.1">
        <property type="nucleotide sequence ID" value="XM_007704919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S1I2"/>
    <dbReference type="STRING" id="665912.M2S1I2"/>
    <dbReference type="GeneID" id="19139569"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39797"/>
    <dbReference type="eggNOG" id="ENOG502S4R7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030267_1_0_1"/>
    <dbReference type="OMA" id="HAKVGVD"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="262" mass="28505" checksum="C035D22873DF9049" modified="2013-05-01" version="1">MAKALRQTQGGRQRKGSLRKAAMARMRERSSSLRKAAKPSIITSFDKPPLNSSPADTTAWVPAIQLPSSPTEPTCASRDVPEPPPSPPLLASPISPMASPAAPYASTTDDDDVMSFYRPLAASSDYSSFAVPSQGPVASLAHRRSTRSNRRTSITALVTPAEIDSDDEWDYSETEWWGWVVLIATWIVFVVGMGSCLGVWSWAWDVGETPYAPPDLEDDATLPITGYYPALIVCTAVTSWVWVVVAWVGMKYFRHAKVGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2S252</accession>
    <name>M2S252_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_97055</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702683.1">
        <property type="nucleotide sequence ID" value="XM_007704493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S252"/>
    <dbReference type="STRING" id="665912.M2S252"/>
    <dbReference type="GeneID" id="19141717"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_97055"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_5_1"/>
    <dbReference type="OMA" id="HDNAYYQ"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="245"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="552"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD61293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="625" mass="71197" checksum="CAC205B919624DC9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2S440</accession>
    <name>M2S440_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_38750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702106.1">
        <property type="nucleotide sequence ID" value="XM_007703916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S440"/>
    <dbReference type="STRING" id="665912.M2S440"/>
    <dbReference type="GeneID" id="19139333"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38750"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_1"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="70"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD61948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="500" mass="54403" checksum="0F5A362716A548ED" modified="2013-05-01" version="1">MESESDNDFRDDKSVSEHEEVEETKPKSALKKGREPAPVVERPELPEQPDPSTLDISTLSPLSPEIISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGYANAKIYQCDNSECPRPTCYRSYKSEKEVDPPCEREGCGGRYRLKRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLNHIIILQNKVDLMREDSAAAHYESILKFIRGTVADGSPIVPISAQLKFNIDAINEQLISKIPVPVRDFSAKPHMIVIRSFDVNKPGAEIDELKGGVAGGSILTGVLKLGDEIEIRPGIVSKDSAGKIQCKPIFSRVVSLFAEHNDLKFAVPGGLIGVGTRVDPTLCRADRLVGFVLGLRGHLPNIYTELEVNYFLLRRLLGVKTADGKQAKVAKLAKNEVLMVNIGSTATGAKVVAVKADAARLSLTSPACTEIGEKVALSRRIEKHWRLIGWANIVAGNILQPIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2S4W1</accession>
    <name>M2S4W1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_229110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702491.1">
        <property type="nucleotide sequence ID" value="XM_007704301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S4W1"/>
    <dbReference type="GeneID" id="19134739"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_229110"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OMA" id="FISWTCC"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF38">
        <property type="entry name" value="PROLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="59"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD62203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="559" mass="61084" checksum="7AD02DE5FBB6B640" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7E6</accession>
    <name>M2S7E6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">COCSADRAFT_37906</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701031.1">
        <property type="nucleotide sequence ID" value="XM_007702841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7E6"/>
    <dbReference type="STRING" id="665912.M2S7E6"/>
    <dbReference type="GeneID" id="19139125"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37906"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_1"/>
    <dbReference type="OMA" id="FPFNKFP"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="217"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="755"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1019"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMD63033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1172" mass="128808" checksum="D8CEDF68FE02D9F7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7U6</accession>
    <name>M2S7U6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_182495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701454.1">
        <property type="nucleotide sequence ID" value="XM_007703264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7U6"/>
    <dbReference type="GeneID" id="19133362"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182495"/>
    <dbReference type="HOGENOM" id="CLU_1053713_0_0_1"/>
    <dbReference type="OMA" id="RELIYGH"/>
    <dbReference type="OrthoDB" id="3673901at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="41"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="264" mass="30725" checksum="896EB393A4AFCC10" modified="2013-05-01" version="1">MDPLNRLKRRLSKRSFPRAYEDPTHPYEDDESDTATMVEIEQDSSFLRLPANVRELIYGHVLGGTQIRVCDTRNCTRRHKCRSRGRKFHFATYFHLRRRHLALLTTCRQIHAETRLLPFALNEFHGYHWDMQLAVYYRLTDAQVGAMTNLRVYFECNDVIYYPALGRRSPSVNLGKDALATLRVLGHLRGLRKLTVEWVGPHDWEHDWDMVEGRMAYLIEEELEQIRGSCDIKVVVVGCDYVEDLDTGPVPVVGDMQKLVSFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7X6</accession>
    <name>M2S7X6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_176363</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705650.1">
        <property type="nucleotide sequence ID" value="XM_007707460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7X6"/>
    <dbReference type="STRING" id="665912.M2S7X6"/>
    <dbReference type="GeneID" id="19133029"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_176363"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="OMA" id="CWWLAST"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_C"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="8 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
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    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024784" description="Probable beta-glucosidase G" evidence="18">
        <location>
            <begin position="17"/>
            <end position="771"/>
        </location>
    </feature>
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        <location>
            <begin position="691"/>
            <end position="760"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    <sequence length="771" mass="84078" checksum="DE0902C9D23D0E84" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2S864</accession>
    <name>M2S864_COCSN</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">COCSADRAFT_259565</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="140" mass="16228" checksum="9265D3EA162C3FCE" modified="2013-05-01" version="1">MIWTEDMGREYTKDYGAIQYCEILFLVCTFYSKMHRTSISRLSSVLTTGTDIAHSRGQVHLCKKTDRNSVGPSMRRRWRQRIPIFKKKVAANTSSGDIWATMRLVLNNIFFFSKDRLFGYGRSETGLLLFVGARKTRSGW</sequence>
</entry>
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    <accession>M2SAF5</accession>
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        </recommendedName>
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    <organism evidence="8 9">
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD64308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701947.1"/>
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    <dbReference type="AlphaFoldDB" id="M2SAF5"/>
    <dbReference type="STRING" id="665912.M2SAF5"/>
    <dbReference type="GeneID" id="19136752"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_323812"/>
    <dbReference type="eggNOG" id="ENOG502S8TF">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034677_0_0_1"/>
    <dbReference type="OMA" id="DPPPFGY"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
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    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="375"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="438" mass="48479" checksum="BE8F975C5A7D9EBB" modified="2013-05-01" version="1">MNDKDPPPFGYTFADDFFDNAAPHYDNNGPSLLSDMENQQLDNFFSSTNPFDLLDPQHIPPALDDKSTAHDYNNWEDFIAPPTVHRVTSTIPDQARLQTTFQQEPHHASSSSLHSSFLANTQDELQAAATLFNHAQPSYTNGRLHSFPEQPAAASNFLTNVAPSLNHAPLPMSVQPHGLMNQRMPSLLPNHGGHALDPQFPPQWTNKAPQHTQTDFGPPLQKIDLKRSYTFGTDNSFNSPSGYSGANGRSAEHSAARHSINDVEETHQHLLRAVAGIDTARTTSVAYQDSSSAVAGASRDDDDEEQSDDSASQEEHDDRPAKRRKKSIAQPGKETPRKAARNGKARKTSLTDESKKKRTAASTQKTHRENLTEEQKRNNHILSEQKRRDLIKQGYKDLNEVVPAVRGGGLSKSQILVEAATFLEKLIEDNIAYRKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBG3</accession>
    <name>M2SBG3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_40996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704536.1">
        <property type="nucleotide sequence ID" value="XM_007706346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBG3"/>
    <dbReference type="GeneID" id="19139883"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40996"/>
    <dbReference type="eggNOG" id="ENOG502STJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1590324_0_0_1"/>
    <dbReference type="OrthoDB" id="5599418at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19391" checksum="440E83DA13361988" modified="2013-05-01" version="1" fragment="single">FRKARLPDIRIFEKGSHEEYTQWKMQIHAFFEDPLIKQKALQYLRTTKQGKGEFLFYENLKVINQLSSNAPSYSTSLPTSTLAAVDEMDWTPNIGAMRPRTRNEYWGTQNQIAQRKEEGSCLRYGIHGHLVRQCKAAVPKRTRKLETVTKVLAATLEDESSDEGKEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCF3</accession>
    <name>M2SCF3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="13" type="ORF">COCSADRAFT_40576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704124.1">
        <property type="nucleotide sequence ID" value="XM_007705934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCF3"/>
    <dbReference type="STRING" id="665912.M2SCF3"/>
    <dbReference type="GeneID" id="19139779"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40576"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089418_1_0_1"/>
    <dbReference type="OMA" id="AEWIISF"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024882" evidence="12">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD60145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="216" mass="24338" checksum="99847309DD768702" modified="2013-05-01" version="1">MPSLLLVVFILQLLLHVINTVGKNTVNELLWILYNKLPTPSSGSAKRCQILKKEIVQLKRELGNTSPQDNFSKWAKLDRQHNKAVAEYQKLDGSLRSHHSAFTSAVSTLRWLGTQGLRFVLQFWFAKSPMFWIPAGWVPYYVEWILSFPRAPLGSVSINIWGIACASMIALVAEAVAAAWVLIMHKPTPVAAEKQRQKQEAMAFSANQKPAEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDU1</accession>
    <name>M2SDU1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_159112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD65463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_3_2_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUI1-like domain"/>
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    </dbReference>
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        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
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        <property type="entry name" value="SUI1_MOF2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUI1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD65463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="115" mass="13037" checksum="1DF0044028617C5A" modified="2013-05-01" version="1">MSIENLKSFDPFAEADEDTGQVKQTQQDYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVSDAEMGEVVQLQGDQRKDVQDFLTDKKEGLGLDAKTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEF9</accession>
    <name>M2SEF9_COCSN</name>
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        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_236611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SEF9"/>
    <dbReference type="STRING" id="665912.M2SEF9"/>
    <dbReference type="GeneID" id="19134886"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_236611"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_37_1"/>
    <dbReference type="OMA" id="DEDNPCR"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="247"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="509"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD60850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65533" checksum="24E427A3054E4392" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SER4</accession>
    <name>M2SER4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_124224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698992.1">
        <property type="nucleotide sequence ID" value="XM_007700802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFF1"/>
    <dbReference type="STRING" id="665912.M2SFF1"/>
    <dbReference type="GeneID" id="19141140"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86793"/>
    <dbReference type="eggNOG" id="KOG1338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017135_0_0_1"/>
    <dbReference type="OMA" id="NAHVNHG"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="25"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD65988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="478" mass="54268" checksum="8761A377BBEEF906" modified="2013-05-01" version="1">MANFQSASNRFLAWFKDCGGVFRDDLLEVRDLRSKDAGRGIIAKQDIPEDTTLFTIPRNIIISIQTSDLAEKLPGIFEQPVDADDDNEDDDNEDDQDHESEALDSWGSLILVMLYEYLQGEASRWKTYLDILPQAFETPIFWTPDELKELEGTSLTTEKIGKKESDRMLRERILPIVTSHPDVFSPPGAPRLNEDDLLSLAHRMGSTIMAYAFDLENEEEQSEDEEDGWIEDRDGKSLIGMVPMADMLNANAEFNAHVHHGDQLQVTSLRESIPAGSEILNYYGPLPSSELLRRYGYVTSEHHRYDVAEISWSLVRTALAEELKLSEDTIADIERKLESELEEFFVIERDAGEPSSYGTLTQPPVLREISTELEEQTKAFLKALKKRDPKRKRSETICNTVLEKALRTRLGQYPTSAKQDESLLSKEGLSKRHRMAVEVRLGEKRLLQEALALVQAGKNTVREHEEEGRVGKKAKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SH12</accession>
    <name>M2SH12_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_298754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697974.1">
        <property type="nucleotide sequence ID" value="XM_007699784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SH12"/>
    <dbReference type="GeneID" id="19136130"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_298754"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024886_0_0_1"/>
    <dbReference type="OMA" id="SEKWIIP"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD66498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59024" checksum="3098D6FAB108EBB5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M2SH95</accession>
    <name>M2SH95_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_182980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702188.1">
        <property type="nucleotide sequence ID" value="XM_007703998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SH95"/>
    <dbReference type="STRING" id="665912.M2SH95"/>
    <dbReference type="GeneID" id="19133387"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182980"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_1"/>
    <dbReference type="OMA" id="HDMDNMH"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <location>
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            <end position="23"/>
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    </feature>
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            <end position="71"/>
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    </feature>
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            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="338" mass="37382" checksum="32AC3A98B9A546B9" modified="2013-05-01" version="1" fragment="single">IDSDQAIYEEDIGTHGRKGGCFSQRRASAPAVDGMGDILKSAIHPTAETPISSLDSRSLSSFPSSVDDDTDPSDSLLVLAPLYIPRSKNNEASARKRPGFTTKRYNPGASSRTWHDWLVRLFAGRKPTLSSQIGHKRTDSFICNSIRAESASQLLKTPKGQDTTKAPTQKHDFKHITSCNHAPRLLLPKVIPSVRTPESHLVTHCISYTRISPAPLTAYTGYTVVAHDDYTPERVVRGFDVPGRSAIVAPLSKRNNTAANLLDRDRDAWSSWNRNITCPTDLPFEKMHPGRVSVPRQSEANSRNKTGGCEMDHLDCQDASQCSNIAVEEYPFSQCCYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHU2</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="21 22">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD66788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_5_2_1"/>
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    <dbReference type="OrthoDB" id="14612at2759"/>
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        <property type="reaction ID" value="UER00711"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:biotin carboxylase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:fatty acid biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
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        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
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        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
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        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Rudiment single hybrid motif"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="63"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="215"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="698"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1522"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="1868"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1225"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMD66788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2286" mass="254551" checksum="564EA0AF509501D3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIA9</accession>
    <name>M2SIA9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_122405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702408.1">
        <property type="nucleotide sequence ID" value="XM_007704218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SIA9"/>
    <dbReference type="STRING" id="665912.M2SIA9"/>
    <dbReference type="GeneID" id="19130522"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_122405"/>
    <dbReference type="eggNOG" id="KOG2699">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SL64</accession>
    <name>M2SL64_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_266756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695676.1">
        <property type="nucleotide sequence ID" value="XM_007697486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SL64"/>
    <dbReference type="STRING" id="665912.M2SL64"/>
    <dbReference type="GeneID" id="19135535"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_266756"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_0_1"/>
    <dbReference type="OMA" id="IHRHPRD"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD67918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48563" checksum="47FADF1EFAEC999D" modified="2013-05-01" version="1">MGDAINATETSLTNLEYGDRWRLHRRLMHTAVGTQAVRNYRDFQAAESALLIRDFFLDSNDFELSIERYSVSVASIIGWGRRIDRKNDYVAQLALAFMEAVDYVIPGVFIMEAIPLLLHAPAWLYELPSKLRSGSATMSRYFYLLTQEGAEAKRDNFAKYVLEAQHKHHLSDVEAAGLTSLIIGGGVDTTSSTMLSCILAMAYFPRIQAKAHAEMDAVIGHDRSPSWTDIDAQKIPYLIALVKETLRWRTVTVLAGIPHANTKPVDYNGYHFPAGTNFTANLWAIHRHPRDFPDPDNFLPERFLDGEGSAKMPYPNKYGMNPFGWGRRRCSGQPLAEQGLLYSMARMIWAFDILPGLDENGNQVKLDIFAYTKSENMRPEPFKVRFVPRSERIKEVMLQEAAEAREALRFYDGETKVTVEKALESPVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLZ0</accession>
    <name>M2SLZ0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_104582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445684">
        <property type="protein sequence ID" value="EMD58161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706139.1">
        <property type="nucleotide sequence ID" value="XM_007707949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLZ0"/>
    <dbReference type="GeneID" id="19129923"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104582"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_11_1"/>
    <dbReference type="OMA" id="NDGRYKE"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6941" checksum="5193989B6E19B3F9" modified="2013-05-01" version="1" fragment="single">LYNDGRYKEAEELDVQVMQMRKRVLGDEHPNTLTSTNNLAFTLQSQARREEALALMEICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMX9</accession>
    <name>M2SMX9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_178332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696101.1">
        <property type="nucleotide sequence ID" value="XM_007697911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMX9"/>
    <dbReference type="STRING" id="665912.M2SMX9"/>
    <dbReference type="GeneID" id="19133134"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_178332"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001366_2_0_1"/>
    <dbReference type="OMA" id="GIMDETN"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="3">
        <location>
            <begin position="129"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="453"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1244" mass="141108" checksum="605039A859B1ACCA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN42</accession>
    <name>M2SN42_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_104477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445666">
        <property type="protein sequence ID" value="EMD58197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706103.1">
        <property type="nucleotide sequence ID" value="XM_007707913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN42"/>
    <dbReference type="GeneID" id="19129912"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104477"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OMA" id="ACAIICV"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="279" mass="32002" checksum="4D1F7A4D640F51FB" modified="2013-05-01" version="1">MVGLRGYVRRKILRNLGLDDWFLLAGLIHCRFQHYPNYYEAIRYGLSRHVHTTTLPERSEFLKIMWVTSVMYGALIMMLKITFLLQYRRVFPLPIFQRLCDASLVFIVIWATAATLGSLLNCPPIKSNWDPLRYKDCKERLRFWYAMGVLHVVSDAAIFAMPLPLLQTLTLPRLQKGVLMGIFSLGFFTCAISIIRLTTLRSSTMSDDPTWAMQNTVLWSTVEVACAIICVCIPTLRPLLRLCTGWQKHSNDITELTPTPRLEEEDGKSAETNINGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN54</accession>
    <name>M2SN54_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_55781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700501.1">
        <property type="nucleotide sequence ID" value="XM_007702311.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN54"/>
    <dbReference type="STRING" id="665912.M2SN54"/>
    <dbReference type="GeneID" id="19140320"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_55781"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043857_0_2_1"/>
    <dbReference type="OMA" id="THKAHAR"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD63745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="132" mass="14866" checksum="8C0EED3F805F1F01" modified="2013-05-01" version="1" fragment="single">IAAAGFKNGDLPNTLTHKPQSRQLVTGVHIVSDISCRSCGSVLGWKYVDAAEDSQKYKIGKFILEAKRTVKGSEWDQSLEEEDNGMVTEAKETDIEFDSQDEDECEDLFSGIWTPQLAARRRKRRAYPQVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNG2</accession>
    <name>M2SNG2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_332275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700852.1">
        <property type="nucleotide sequence ID" value="XM_007702662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNG2"/>
    <dbReference type="GeneID" id="19137097"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_332275"/>
    <dbReference type="eggNOG" id="KOG3039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053742_1_1_1"/>
    <dbReference type="OMA" id="PCVTKFM"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001463">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="247"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD63860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="358" mass="40094" checksum="C3C79F13D930948F" modified="2013-05-01" version="1">MPPPKTVFTSYERNSLKDRWGSQSTRLTRDSFLPFGSCQLCLLPSVDPVCCSQGDLFCRECALTNLLAQKNEMKRLEKLNERQKLEEEENELREEEEARLRAVEEFELVQQGLSFKAGSSAKMVGREGGKIMVEEEQDPKAASQGRGTKRKFEIDEEELKRIANEEQRKAKRNLDEERKAAKGYLPSFWVPGETPDQHHKTAEKAKNTPICPSSSPDQPHSLSLKGLTSVHFHEEKSTETGKPVRTCPSCQKALSNNTKAMLAIPCGHVLCKPCVDKFLRPEHRHHRDAHDDSPEPDSIHCYVCDADLSAAPDAKEGKKRKKKEQAPKPGLVEIQSEGTGFASGGKAMVKREGVAFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP43</accession>
    <name>M2SP43_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_320632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699960.1">
        <property type="nucleotide sequence ID" value="XM_007701770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP43"/>
    <dbReference type="STRING" id="665912.M2SP43"/>
    <dbReference type="GeneID" id="19136627"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_320632"/>
    <dbReference type="eggNOG" id="ENOG502QPJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057759_0_0_1"/>
    <dbReference type="OMA" id="NHWPLRE"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00838">
        <property type="entry name" value="MPP_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052963">
        <property type="entry name" value="Pantetheine_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492:SF2">
        <property type="entry name" value="[ACYL-CARRIER-PROTEIN] PHOSPHODIESTERASE PPTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="329" mass="37480" checksum="307921CA2D755461" modified="2013-05-01" version="1">MDPLLAAAETAAADFARTPSPPNTPPSAATLPLSRLWAIGDIHLSFKGNREALEKLIPHPHDDLILCGDVGETAEHCRMAFTKAKECFKNVFWVPGNHELYTLPTNKENGARGEAKYMECVEIAREFGILTPEDDYMLWQGEGGPCLIAPIFTLYDYSFRPDWVKLQDALAWAREQDIEATDEHLLHPDPYSSRIEWCNALVDKTEKKLEAAVAAHPDVPLIIVGHWPLREDLVKLTKVPRFSLWCGTKRTENWHNRFNAKVVVSGHLHIRRTDWIDNTRFEEVSLGYPRQWHDCVEHGLDINDLLREILPGPKTPPVGECRTIWRHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP88</accession>
    <name>M2SP88_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_130322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694482.1">
        <property type="nucleotide sequence ID" value="XM_007696292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP88"/>
    <dbReference type="GeneID" id="19130780"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_130322"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_2_1_1"/>
    <dbReference type="OMA" id="HHMCRFQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="403" mass="46749" checksum="F1F565F782DCD23F" modified="2013-05-01" version="1">MYKLTIWPPPRRPLRPLLRALSSHWKAILVIAFLMLLEVLFHIHSFTITRPSRPLDAPFHTGCQNPVANTTARENAVLLMLSRNSEVSGAVASVRSTQKQFNDHFGYPWVFLNDKPWSEEFKEKVGAAVQNTSAMGRVSVEFSTIPKAMWGFPSWIDQDRARRTMKAMQEDDIQYAAKEEYHHMCRFQSGFFYKHPSLLPYKYYWRVEPSISFTCAIPYDPFSHMRRNKKRYAYTIALWERGKTVPSLFRKLSDYKTTRAIQTSPLWTALHDPSFAPWPLRPALAWLRNRNAEGDLWNMCHFWSNFEIGDLDFFRGEAYTTLFDFLDREGGFYYERWGDAAVHSLAVAMLLEPGELHWFSDWGYVHGGLQVCGEERGGCGCECDAQARVVEPVCLERIGATMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPL0</accession>
    <name>M2SPL0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_117390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700094.1">
        <property type="nucleotide sequence ID" value="XM_007701904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPL0"/>
    <dbReference type="STRING" id="665912.M2SPL0"/>
    <dbReference type="GeneID" id="19130359"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_117390"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031814_1_0_1"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="228"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD64245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="485" mass="53529" checksum="C5FD3E7FF9DBA9E1" modified="2013-05-01" version="1">MGDPQFAKYPDLQLSQHIFQLTNPAASKQAKQAALKSVQDGITENKMAPLYRYLAHPVDGVLNAQGEGSADQPSKNRRPSASLATMLATRTPTLEVPLPWDEKLYESLKAECEKELEAIQKEEEEAEEKAGETEVQAARGKRAELYNRIGDKDKAIASYEAIFEKTGILGTKIDLVLAIIRIALFFGDRILAKKSIDRASALVESGGDWDRRNRLKAYTGLHYLTVRSHSQAAPLLLDSLSTFTSYELCSYSNLVVYAILAGSVSLKRVDFKSKVVDAPEIKAIVGTSEEKLSAITGQASAGPAAGDEEMADASGSTATPVPTVVNLTTLGGSQDQEAAVDFSPLSKLVKSLYEGDYKGFFGALGEVETNFLSQDRYMYEHRGWYVREMRLRAYQQLLQSYRVVGLESMARDFGVTIDFLDKDLARFIAADRIPCTIDRVKGIIETNRPDDKNKQYADVVKQGDQLITKLQKYGQAVRLRGSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQR8</accession>
    <name>M2SQR8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_348577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
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        </cofactor>
    </comment>
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        <source>
            <dbReference type="EMBL" id="EMD59097.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
    <sequence length="350" mass="40149" checksum="6EF8A9148F47CA26" modified="2013-05-01" version="1">MSPSILHDYNETSIFLGKKADIKQKSDSSAPAVSLPSAAEFVPPPSRFVAECHPLEKQITAEVDGYFLTHWPFKTAKDRKKFVAAGFSRVTCLYFPLSMDNRIHLACRLLTILFLIDDILEDMSLEEGCAYNEKLMPIARGDVQPDRNVPVEWIMYDLWEDMRSHDRQLANDVLEPTFTFMRAQTDKARLTIRGMGPYLIYREKDVGKALLCSLMRFSMDLQVSPEELASVQPIEQNVAKHLSVLNDILSWDKELLAAQTGHPEGSALCSAVQVLADETSLTYAAAKRVLWVMCREWEYEHEYLVEKRRRDERFPHSENLMRYIKGLEYQISGNEIWSKTTLRYNAPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007706604.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SSP5"/>
    <dbReference type="GeneID" id="19133486"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185038"/>
    <dbReference type="eggNOG" id="KOG4124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_293008_0_0_1"/>
    <dbReference type="OMA" id="STVQDMD"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ADC_dom_sf"/>
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        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="611"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="672"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="171"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="398"/>
        </location>
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        <location>
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            <end position="471"/>
        </location>
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        <location>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113176" checksum="4C50A492CD5ECA59" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2STR9</accession>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703826.1">
        <property type="nucleotide sequence ID" value="XM_007705636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STR9"/>
    <dbReference type="STRING" id="665912.M2STR9"/>
    <dbReference type="GeneID" id="19133453"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_184289"/>
    <dbReference type="eggNOG" id="KOG1720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017787_1_1_1"/>
    <dbReference type="OMA" id="KFERVDM"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="247"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="319"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="410"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="521"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD60491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="629" mass="70091" checksum="7BA8A84BB79C5A59" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY20</accession>
    <name>M2SY20_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_188013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696932.1">
        <property type="nucleotide sequence ID" value="XM_007698742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY20"/>
    <dbReference type="STRING" id="665912.M2SY20"/>
    <dbReference type="GeneID" id="19133611"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_188013"/>
    <dbReference type="eggNOG" id="KOG4126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008539_6_0_1"/>
    <dbReference type="OMA" id="RSGMEYP"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.140">
        <property type="entry name" value="Alkaline phosphatase, crown domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042085">
        <property type="entry name" value="Ap_crown"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Kema G.H.J."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="518"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="518" mass="59500" checksum="E4134E2A36C1574E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name evidence="2" type="ORF">COCSADRAFT_24085</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="80"/>
            <end position="100"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="308" mass="35577" checksum="5E1296D275233B78" modified="2013-05-01" version="1">MKSHHTYEYMGLTPEAARLIYNDGKKIRDGIMDNYGEEFDSEFLECSLEAYLVQRVTEVCDDEIFGNYFRTLEHVNEHVLEQEQSLGPNPRRRATEDDVVIPPPPGHRVLFKSVEFHKAQAVFGTEETDNGEMSQELNLLPLLSSRYSTDLCRYGGLYLTDALWVAKAHALYPKRTCPPADIRTLELHAPNEHFDKLKSHRCGNSISKHLMKIQSAFQILHAPCTTQNYRLGHWNQITDRHLLTRMITDEYGAPKQEVAMQYVWPNPEAIFDLSEDCKDKTRLGKPLKDWSLVKELEKNTLVKERSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
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    <dbReference type="STRING" id="665912.M2T0R9"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_33100"/>
    <dbReference type="eggNOG" id="ENOG502S8JK">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025540" evidence="1">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="230" mass="25628" checksum="624D241708357EDE" modified="2013-05-01" version="1">MISPLPLLALFTHLATSTMSANTTTTTIEPFNLSAKAGTDIWRKPPSTNVFNAAFYPSTLATYPLKQFQRAKISFALPPSNELRRYDQAGLVLHLTKEGVADNATKWIKTGIEFYTGKPFVATVGCDIWADWSLVPMPEFVNGTQPAATIEARKEQDELGKSLWIYWIVRDEQGKEVERRPLREVNWFAAAEDEGWNVSIAGYVARPTTAGGNELLEAEFKEGLEIEVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2T100</accession>
    <name>M2T100_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_92428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007703010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T100"/>
    <dbReference type="STRING" id="665912.M2T100"/>
    <dbReference type="GeneID" id="19141448"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92428"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="OMA" id="EYCGHIV"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
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    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
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    </dbReference>
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        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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        <alternativeName>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701497.1">
        <property type="nucleotide sequence ID" value="XM_007703307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T274"/>
    <dbReference type="STRING" id="665912.M2T274"/>
    <dbReference type="GeneID" id="19131355"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_145700"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037142_0_0_1"/>
    <dbReference type="OMA" id="SKLFWGS"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="286"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD63311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="442" mass="51122" checksum="21DBE7DFD1C96C96" modified="2013-05-01" version="1">MSNQCILRITRELGEIQRGSDLSIAVACRDIDVRHVRALIIGPPDTPYEFGFFEFAVKFTRDYPTKAPSVTAITTNGGRTRFNPNIYAGGKVCLSILGTWRGERGEEWSSAQGLESILISIQSLMSGNPYENEPGFEDANSDYDKKNQEAYVDKIRHESLRISVIERLEEYLGINRQRPGVTIYNAEEDYQSNRDDAPFEPFKDLCKRRFLWYYQSYLTRVDEAVKQNKDGDRFEKMPFEGPGNTMEGVFQYTSLRERLVKIFETLNKEMESWALEGMSAVKKEMSIANNLQRQYEQIVEKYKKQDAIALDLDLVDKNPFVWQLVLFGRPMTNLDGGMFRIRLYISPKFPDVLPRVRFETPILYHHRVSPDGILCYDAARKDDMRSHIEAIIAAIEEESPAYDPRTLVNPEAAKLFWGSPEDKKLYNRRLRRSAQDSAENFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2T275</accession>
    <name>M2T275_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_161625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701350.1">
        <property type="nucleotide sequence ID" value="XM_007703160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T275"/>
    <dbReference type="STRING" id="665912.M2T275"/>
    <dbReference type="GeneID" id="19132111"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_161625"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054430_1_1_1"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="262" mass="30192" checksum="B8C69FB068DCB596" modified="2013-05-01" version="1">MRNRTGPYGGLLRLEPHMVVRPVRILQAARMVSTLVGQSGREYSLQKVLQRHPKKPELSVCLALYGKTPYAVKPVSESILGHLQKFKAGFKTHPHLRNPIDKIEKRDHSCLRILQNRFARIDVKPEDIFLNWYVDSSDEFHLGKIVLGDMDCALKLKGDKLLSYKIGNIIWRKSGRTARKRRRKAFQSLLLYSFGALVQHVDDAKTGEILTGLWQAVKENEFRNLTDEAKRLILRMTNLDPAKRATMSEIVKDDYWVEDENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3C2</accession>
    <name>M2T3C2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_55083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700500.1">
        <property type="nucleotide sequence ID" value="XM_007702310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3C2"/>
    <dbReference type="STRING" id="665912.M2T3C2"/>
    <dbReference type="GeneID" id="19140315"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_55083"/>
    <dbReference type="eggNOG" id="ENOG502SSCW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718776_0_0_1"/>
    <dbReference type="OMA" id="WDRFDYF"/>
    <dbReference type="OrthoDB" id="3933088at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="391" mass="42388" checksum="7787DE445EEA2D4E" modified="2013-05-01" version="1" fragment="single">EYDDYDAEFFYVEDEYMAADDLAEHAVASPPPATCGDEDMEEDWDRFDYFNDLEYASDGYDDTKFQPLDVKGAKAGSKRKRPVRRPPRKSKADTNTSMGAEPAAPTHSPIVWRSQADRGVKPKALEENAEPYALFKNWRERLANIPEWAKGSPPTSPGAPSISSEKGKGKMAFITEPASPPYDEDEEEGHDEAMSEQGQGISQEALLAALQRQLAAAGGPLSGMDPQQLLEFAMRMAADQDAGDDIAGEMADAMLEGSDEEDDGDAEEKLLSWVAQQRNGNKEVAEADSVPTDVAPSSKRLPTPPPSTATRNVSASQTDTTPSVPTPTSQSTDSKIPKPSRKRKADDEDSTDAPIKTAKKRSTRSFDAPTAASQAKAATAKPATRSRTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4N0</accession>
    <name>M2T4N0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">COCSADRAFT_32122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694204.1">
        <property type="nucleotide sequence ID" value="XM_007696014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4N0"/>
    <dbReference type="STRING" id="665912.M2T4N0"/>
    <dbReference type="GeneID" id="19136648"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32122"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="327" mass="35697" checksum="C2AA3E2CF9FE86AD" modified="2013-05-01" version="1">MAVTEQDTQVVTLRKILTSESEPLARRFRALFSLKYLAGLNPPTEQTVPAIEAIGAAFSSPSALLKHELAYCLGQSGHDAAIAPLRAVLQDKEEDSMCRHEAAEALGALSDKGSLDLLKQLRDDVQEVDVVRETCDIAVDRIEWDHGLQKGQEKLKKSDFTSIDPAPPLPQSTEKLSIPELEKTLLDTSLPLFQRYRAMFALRDLSSPPDLPTAIPAVQALARGFSDPSALFRHEIAFVFGQLSHPASIPSLTEALSNTNEASMVRHEAAEALGSLGDEDGVEETLRKFLNDPEQVVRDSVIVALDMAEFEKNGEMEYAIVPQVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4R6</accession>
    <name>M2T4R6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_105936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD69425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="19129984"/>
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    <dbReference type="eggNOG" id="ENOG502QU3W">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="697"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD69425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="905" mass="101271" checksum="C24705D51351B4B8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2T573</accession>
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        <recommendedName>
            <fullName evidence="15">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_160373</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD64127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701815.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2T573"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_1_1"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
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    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="283"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00734"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD64127.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="59904" checksum="492BE0C0C99171F3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5L7</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_89856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5L7"/>
    <dbReference type="STRING" id="665912.M2T5L7"/>
    <dbReference type="GeneID" id="19141320"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89856"/>
    <dbReference type="eggNOG" id="KOG0507">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_45_2_1"/>
    <dbReference type="OMA" id="VRWLLQF"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
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        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD64526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="100" mass="11023" checksum="012D811D27821DF0" modified="2013-05-01" version="1" fragment="single">TPLLWAAERGHDGVVKLIFQTSKVDVNCKVRWSGRTPLSLAAEKGHKAVFQLLLEIDKVEIDSEDDSGQKPLSWAAKGGHDDVVKLLLETDKAKVESDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">COCSADRAFT_141120</name>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699404.1">
        <property type="nucleotide sequence ID" value="XM_007701214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6I4"/>
    <dbReference type="STRING" id="665912.M2T6I4"/>
    <dbReference type="GeneID" id="19131190"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_141120"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_3_1_1"/>
    <dbReference type="OMA" id="THNWIAS"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD64851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="575" mass="64673" checksum="2D2507C8B5A76D86" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7X6</accession>
    <name>M2T7X6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_198312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7X6"/>
    <dbReference type="STRING" id="665912.M2T7X6"/>
    <dbReference type="GeneID" id="19134060"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_198312"/>
    <dbReference type="eggNOG" id="ENOG502QSAP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042679_1_1_1"/>
    <dbReference type="OMA" id="AINCWAS"/>
    <dbReference type="OrthoDB" id="2125396at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNI-like"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="48168" checksum="B36CAAC393D4636A" modified="2013-05-01" version="1">MCNIGNYANYLPDELLLEILSHLESWSRLERQITLARFSAVNRYAIVAIQPLYEAPFLLGRAYDLFVRTISPSVNARIKPSPLSGLVKDLDLSHIVHQGAKSTTARLLGRTKSSLEVFVAPQASFAINCWASLSKCTRLRVLDLSLVSECIDFQSLNQTIRQLPQLRELYLPRCSSRYEKATSPTSTLRWPPRLQHLALSGSVSGQFLWDMLQQPDNFPPTFSSISIHHCPALDHSGVKPLLSTLATNLTAVELRDLPAVKQGRLNGVLEWLPKLVSLTIALDYIDSRFGSMPMDFSQARWEEARPLTSLTLVSSGRQGDPARSFTPTDLYSLIDERWLGCLRYLNVGVSTEWDKEYEEELGALEYLLIEELDKENWVEGRWHYEDIWSLIGTTRNMDYEEWIHGTTLGRKMRPRFRLLQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2T849</accession>
    <name>M2T849_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">DUF8040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_305378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T849"/>
    <dbReference type="GeneID" id="19136260"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_305378"/>
    <dbReference type="eggNOG" id="ENOG502RG6G">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1475857_0_0_1"/>
    <dbReference type="OMA" id="AYGWDHD"/>
    <dbReference type="OrthoDB" id="3853825at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="178" mass="20469" checksum="B2878C6256D9FC82" modified="2013-05-01" version="1">MDGIEAMGARRAMSLMFTVPERFISFAHMDQKTFFELSDWILANVASQITPEISVEESLFVFLDIVAQGNSFSEVAYGWDHDVELTQGIFLNVLNALTVLRERREIADSCPPFTQTRKRWEVARRWNQKRSRPNPSGVVRIGYDEMCRDGLEVDQECLKEALVALNNFIHENADYDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8H8</accession>
    <name>M2T8H8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_113823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698470.1">
        <property type="nucleotide sequence ID" value="XM_007700280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8H8"/>
    <dbReference type="STRING" id="665912.M2T8H8"/>
    <dbReference type="GeneID" id="19130237"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_113823"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OMA" id="GFAGISQ"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000104">
        <property type="entry name" value="Related to enoyl-CoA hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF68">
        <property type="entry name" value="CARNITINYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="281" mass="30064" checksum="5990B31372420BDD" modified="2013-05-01" version="1">MSSVKPQTTPPPTSHVLLSYPADHVLLVTINREKQMNSIPFEGHLEMGEVFDWFDHEPNLRVAIVTGAGTKSFCAGQDLIQLGKIRSGQLKATPGLMRHPLSGFGGLSRRMGKKPVIAAVNGFALGGGFEIVLGCDMVVAAPHATFGLPEALRGIFAGAGGPPRLVRNVGLPIASEMALTGKPITAQRAKELNLVNRISPSKETVVQEALKLASEIAAISPDSAIVTRAALREAWETGSVERATQLVIEQYNHGLNTGENALEGLRAFAEKRKPNWQPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAG5</accession>
    <name>M2TAG5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_310717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698923.1">
        <property type="nucleotide sequence ID" value="XM_007700733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAG5"/>
    <dbReference type="GeneID" id="19136374"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_310717"/>
    <dbReference type="HOGENOM" id="CLU_1855105_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="138" mass="14576" checksum="6B01B74B2C064882" modified="2013-05-01" version="1">MVEGWAGARGVIGHVACPEALSDARACNPCPQSWRSRVVGAVDCFSPPCSLALFLSLFFFFHLSDPVVVVCVEAAVPAQYPTSTAQHCTAPQHPVAARTPHPGCVSLRQPGLILVSARLPANSALNAAIQRRGRAYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAH7</accession>
    <name>M2TAH7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_310854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698933.1">
        <property type="nucleotide sequence ID" value="XM_007700743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAH7"/>
    <dbReference type="GeneID" id="19136379"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_310854"/>
    <dbReference type="HOGENOM" id="CLU_2922464_0_0_1"/>
    <dbReference type="OMA" id="HVYLHHV"/>
    <dbReference type="OrthoDB" id="10425707at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8263" checksum="378DCCAC46143A9C" modified="2013-05-01" version="1">MQVCGGLYVGDPDTQVHVYLHHVLELGVCDACVRVKSMQAHLRTHTYTHTHTLTHSHTHTHRHTCISLLLLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAT0</accession>
    <name>M2TAT0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_297228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697846.1">
        <property type="nucleotide sequence ID" value="XM_007699656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAT0"/>
    <dbReference type="GeneID" id="19136106"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_297228"/>
    <dbReference type="HOGENOM" id="CLU_1085891_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="256" mass="28525" checksum="0788D9F09C36BEA8" modified="2013-05-01" version="1">MVLHTRHAFSLSHTHTHTHTHTHTPPRQAKYPLQACIFCPQSHRLLLQFPPPSLLSSTKQKKSEEKVSSITVMHTLPFAKRSRNRVSRSQTRHRYAAAEVRDWGSRRARAVRLSFVASCASFCVPASRTTPSSYRLERQNNPSQKHSRTPLRLSRPYGISLSIYLVDVSSARFSTHTTQPDSAHYLSSAKRPSAGGGSSAFDSRRPRKGLARPFLALRFNDAGQARSLCPFSTGLVLSLGASRLRVLAVSGRTAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAY6</accession>
    <name>M2TAY6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_198855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD66042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699030.1">
        <property type="nucleotide sequence ID" value="XM_007700840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAY6"/>
    <dbReference type="STRING" id="665912.M2TAY6"/>
    <dbReference type="GeneID" id="19134076"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_198855"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1147108_0_0_1"/>
    <dbReference type="OrthoDB" id="4241701at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF132">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MPSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD66042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="242" mass="27110" checksum="84DA969D59B0A205" modified="2013-05-01" version="1">MFFHQHHRHSAQILPLETMPENEHESAFDEALRQAMQIGVELKNEIERLENHSPQLILFEGTLLFYLEALLLLSSLPNESKRSSGDFVDILRQCGSKRRNARLVAQQTPDSWAGGFPQLTLALQGYSHTIICFVFIKVGSSINVQQQVVRILSTMGTYYSTIHLLSLYNGTSNLDQVHPASENAIQALPKNVESVEDICGICLASMEIAKMPCNHQYHSECLSGWLGTANSCPNCRKKLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBD4</accession>
    <name>M2TBD4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_112979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697983.1">
        <property type="nucleotide sequence ID" value="XM_007699793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TBD4"/>
    <dbReference type="STRING" id="665912.M2TBD4"/>
    <dbReference type="GeneID" id="19130201"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_112979"/>
    <dbReference type="eggNOG" id="KOG4589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_2_0_1"/>
    <dbReference type="OMA" id="WSQVAVN"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="75"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="358" mass="40604" checksum="AFCD19E72ECFE729" modified="2013-05-01" version="1">MLSHRLFRQITDSLLLGFRVYPEATVCFASACLTCSSRTHIFAQSIRHSSSSSTRWKSRQGRDFFAKEARVQGLKSRAAFKLLELNDKHKLFRPGQTVVDLGYAPGSWSQVAVNRTSPDGRVIGIDLIPAQPPRGVSTIQGDFLSPIIQDQVRAYVRDTDLGRPRRQVSSSTSEGLTEEELDEMQRGYIEIERQAQLDGADPEAIGRPIEDWDGDKPISTNLSLKERDMQRGRTVDVVLSDMSEPWDQTTGFYKKSLSDPYIRMMNTSGNAFRDHTGSMDLCMAALMFAFDTLKTDGHFLCKYYKGAEEKAFEMKLKRLFAKVHREKPESSRAESREAYFVALRRKETPTKEDVFGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEG7</accession>
    <name>M2TEG7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GEgh 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_135799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696868.1">
        <property type="nucleotide sequence ID" value="XM_007698678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEG7"/>
    <dbReference type="STRING" id="665912.M2TEG7"/>
    <dbReference type="GeneID" id="19130986"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_135799"/>
    <dbReference type="eggNOG" id="ENOG502SJ8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047729_1_0_1"/>
    <dbReference type="OMA" id="ANIVNQC"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026447" description="GEgh 16 protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="35692" checksum="B433CFCE3B75162C" modified="2013-05-01" version="1">MYFSAATSVALAALLTTVHSHAVILAAVGDSGESQGFLVDPELARNCTTISPCQQDATIIRDEEITQNIVNACGRTEIAGNIDIGEQTENELAAGRMAKVSAGSTVAVTIHQVNADGAGPFECDMDETSNAVTTFTPLKVSNNVPGSFGLSQAKEKEFTINVQMPDKFNCLGASTGNICTIRCRNNAIAGPFGGCFAVQQTDGTGRTDKSASAVDTAQTLEGISAQILQNQKDLPAAIAANQAAGAAGGNEGASAISALLPEATQDPNAGNGNRGNQNGNQGQGQRGQQGQGQRGQQGQGQGQGQQGQQGQGQGQGQGRGQNQGNGNGQNQGNRNNRLRRFASKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF02</accession>
    <name>M2TF02_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature viability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_168983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697370.1">
        <property type="nucleotide sequence ID" value="XM_007699180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TF02"/>
    <dbReference type="STRING" id="665912.M2TF02"/>
    <dbReference type="GeneID" id="19132608"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_168983"/>
    <dbReference type="eggNOG" id="KOG2637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028555_1_0_1"/>
    <dbReference type="OMA" id="TAQHFTL"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54149" checksum="71E01836A97188C7" modified="2013-05-01" version="1">MPRRKFIDKKTAINFRLVHRAQNDPRIHDEDAPQMVFAETVAPNQREVSEPAGSSRASQYSAATGRSKIKSRRDLESEYGSKVRNNEGEAANYGIFYDDTEYDYMQHMRDLGSGGGDAYFVEAKQEKKGKQKMDLADMLRDASLNDSKSQADMSVSSNISSVSDFFGEDMAPSEFVRKTTYQDQQNIPDALSGFQPDMDPRLREVLEALEDEAYVDDEEDIFNELAQDGYEIDQREWDASADFDDDERDPMDRFLDEEDPGWETDDTIKASSPKVKATKASEDSTDPSSLPAPDAAPAPADAEDMAYLKEFKKFKEDVKAAKPNKPTDAPADTQSFITGASALTSGGRKKKRKGAMTSTSGYSMSSSALHRTEGLTLLDQRFDKIEEEYANDDIFDFPDDASMVSGMSKMSGMTGMSQWSSSQAPPLLRSDFDSIMDDFLGNHHTQGKRRVKKGKQQTGLEQLDEVRKGLGAPIVKPKDHFSVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFN2</accession>
    <name>M2TFN2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_33021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695436.1">
        <property type="nucleotide sequence ID" value="XM_007697246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFN2"/>
    <dbReference type="GeneID" id="19137006"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33021"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="OMA" id="WSTCKVR"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF4">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="90"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="552" mass="61497" checksum="B3E27EC6ECCC891A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGH4</accession>
    <name>M2TGH4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_137205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697380.1">
        <property type="nucleotide sequence ID" value="XM_007699190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGH4"/>
    <dbReference type="GeneID" id="19131040"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137205"/>
    <dbReference type="eggNOG" id="ENOG502QTVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_0_2_1"/>
    <dbReference type="OMA" id="DNHDFNQ"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025921" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="247" mass="26911" checksum="29334957BE114672" modified="2013-05-01" version="1">MRFASVPFVALAAVGVVSAQGAMDTWNPAGTGDSRGPCPMLNTLANHEFLPHNGRNFTLDILKHALKTALNISDDVTVLLHTAALTTNPGGSTWGLDTLSKHNILEHDGSLSRQDNAINGDSTSFNATIYQRTRSFFTAPTISLQMAANARLARMLDSLKINPQFSITLPAVGFSHLETAIYMIVFGDRSKKTAQRDQVDFFFAENERLPTELGWKTPSTVISGADVKEYQNLVVANTKYQPDIMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGI9</accession>
    <name>M2TGI9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_352865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697392.1">
        <property type="nucleotide sequence ID" value="XM_007699202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGI9"/>
    <dbReference type="GeneID" id="19138187"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352865"/>
    <dbReference type="HOGENOM" id="CLU_688883_0_0_1"/>
    <dbReference type="OMA" id="QCDWPSS"/>
    <dbReference type="OrthoDB" id="3801582at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="400" mass="42878" checksum="28F0FFFA9A058ECE" modified="2013-05-01" version="1">MTSQNSFQPLSDDVNLASSNFTEDSFFDFNGASSDGNLPIADLSDDLPLSFAEEEFWGGFEELPPLEPSVSQSSFFDSFASEDTFSSFQSDMSLWTTEAFNEESVNIQCDWPSSPPTKTSDLPTVDSSVTTPPVSQAIDPARSKPSEQPVGAIEALWGPIMSSSPQKSALTPPTKKEPLPKMKTTKVIKQKTTPKKTAPKKKTPKNLSTPTRRSEDRSIKDLYNSTWASLTDEEKGRLLLPLLQGVDPNTGKKITKAGTLLLPPDYEVIGANTQIDLTQSPYPHANTTSSSPSASTAHNSDSVLAVPEYLPYISDTTSFNDVNLDAIEAFNRCGMGATDAMGDSDIDTRGTVGKGLGGPCGNGIIGGAIEMPTPPSVYGSARQQEALERNAMLCAQGPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIG9</accession>
    <name>M2TIG9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_33397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695535.1">
        <property type="nucleotide sequence ID" value="XM_007697345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIG9"/>
    <dbReference type="STRING" id="665912.M2TIG9"/>
    <dbReference type="GeneID" id="19137160"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33397"/>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021430_1_1_1"/>
    <dbReference type="OMA" id="GWHRSYN"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MBOAT"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="636" mass="73108" checksum="905FD13CAB4865AC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TII7</accession>
    <name>M2TII7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_205525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TII7"/>
    <dbReference type="STRING" id="665912.M2TII7"/>
    <dbReference type="GeneID" id="19134313"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_205525"/>
    <dbReference type="eggNOG" id="ENOG502S0YX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_572377_0_0_1"/>
    <dbReference type="OMA" id="MARVDQH"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="484" mass="52715" checksum="357E60086D3F51B3" modified="2013-05-01" version="1">MFGTLHCNSPTKEAEFVERPYGSLNPGMNSACDRCRAYKVKCTVSGKSCSRCRRLKKTCSFTSVRQRSSQRVCKTEVNSKRQESQSSDRSAQPQTSPSPKDSGNEGEDHIKQRGSISLGQIDKNDGSEKGDPQIPDYTSHQLSEASSSSSSSSSSSSSTTSSLPFLADYDQRDMSEQRDDLCTCSILPFPFCSSSVHYNSPDAIARSNIGTPQALPTPPASRDETPQQQLPNSQLHDPQFEMGPIDTQSLDISALASSMYWSQSSFEKTCQCLADVIFALEKLEASCSSGSRAGLDSIVANQKEATELCRCMLKCSNCMAKRENFVLIVFMSERIVVACSRIVTMYRMEDGGLRNNTHNHTGTTTVTPSQLACLPGPHLSGTTTDMDMDSQCLAAAAASVAASSPSRPPTSGWQQLLLGDYKINSALEWDHLVRALINFQLRAVKALLSDVKSIGTMILGDAQKESLAHAETIVNKLEQDIYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKB6</accession>
    <name>M2TKB6_COCSN</name>
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        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_206558</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694546.1">
        <property type="nucleotide sequence ID" value="XM_007696356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKB6"/>
    <dbReference type="GeneID" id="19134329"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_206558"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031986_0_0_1"/>
    <dbReference type="OMA" id="PPYEMTQ"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD69127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="422" mass="45481" checksum="DD451195D04530F6" modified="2013-05-01" version="1">MHPGSDPMGAPPSFAARRPHAQQLGSFELPPPPMHKYPFSNTITTSQSQQAPVTIASVGNLLTPPNTNHSDVISSTGVSAAGSHYSTAMAYSNGQYIYSPPAQASAAQYGYQAAHHQQNQYGQARGGMFAPSRGEGQLGRQDSLGKGLNPPPYEMTQQLPPFTPSSNGSSMPSISTQHHHHQQMMGNQTPVSSSGPQQSPALSQDSFRPPQPPTPTYSYHNSGTPQHSNFPYSTGPSPTLSQQQSPISAGGSMQRMSPAVSQGPIPSIPSNNPAHSPYQYQQRPSLQYRGGQAPVFSNVQNPAGGLALVGHPGMMSGFNSGHAAQMPHFMGHPQHQPPTANDRPFKCDQCPQSFNRNHDLKRHKRIHLAVKPFPCNHCDKSFSRKDALKRHILVKGCGKVVGENDTKRESHSPRAEDLKSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLW9</accession>
    <name>M2TLW9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_177383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694936.1">
        <property type="nucleotide sequence ID" value="XM_007696746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLW9"/>
    <dbReference type="GeneID" id="19133081"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_177383"/>
    <dbReference type="eggNOG" id="ENOG502T6K0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105525_0_0_1"/>
    <dbReference type="OMA" id="WKKMHTC"/>
    <dbReference type="OrthoDB" id="3794829at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="228" mass="25225" checksum="B69F5EA3242A81EE" modified="2013-05-01" version="1">MCLYWKKMHTCGHPSDRPYIEMCRPGLLSNNVCLDIKEDEQYRPSHFPCYLCIKAEARAEIEAQVRSDQEAIAKARQARENAVKEKVAAEIRAKEERVRREAREKAAREREAEQRAKQEKEEDEIRAKKEGGPWIETLGGKKFKAKKNAGSSGTTSSPTKLLNSLSVAKMATGPKNTKENSTGNGDGGEMTGSKTVGVDMGGRAGVWGPKKILTRQENDVGTGFGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2QX93</accession>
    <name>M2QX93_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_203422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704679.1">
        <property type="nucleotide sequence ID" value="XM_007706489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QX93"/>
    <dbReference type="STRING" id="665912.M2QX93"/>
    <dbReference type="GeneID" id="19134258"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_203422"/>
    <dbReference type="eggNOG" id="ENOG502SBHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015423_0_0_1"/>
    <dbReference type="OMA" id="KYGVENR"/>
    <dbReference type="OrthoDB" id="2587563at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="696" mass="76202" checksum="6D9B521BBF51F20C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2QYA7</accession>
    <name>M2QYA7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704091.1">
        <property type="nucleotide sequence ID" value="XM_007705901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QYA7"/>
    <dbReference type="GeneID" id="19139746"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40467"/>
    <dbReference type="HOGENOM" id="CLU_2352211_0_0_1"/>
    <dbReference type="OrthoDB" id="10293305at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="101" mass="11408" checksum="2CEA83FB9A5E27A3" modified="2013-05-01" version="1">MVDGSDDERVGQVFRDYRGWKEQDMGMGGTRRTVPWWAPACRMQMQQGENGSIASAFCLCVCGIIVLWVFRETGMRAMIVENVPCRLNPEVYTSVAVIVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2QYM4</accession>
    <name>M2QYM4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_40541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704113.1">
        <property type="nucleotide sequence ID" value="XM_007705923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QYM4"/>
    <dbReference type="STRING" id="665912.M2QYM4"/>
    <dbReference type="GeneID" id="19139768"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40541"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023312_0_2_1"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000104">
        <property type="entry name" value="Dual specificity phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="68"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD60109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="324" mass="36006" checksum="0C672BA7DF0E0933" modified="2013-05-01" version="1">MALLDRVPGNLNLYIGGIFTLRRREALEQANITHVLSVLRTPLDDALFAPFKHMVVEVDDVDDENLLQHFPATNRFIRDGLDAGGGVLVHCAMGKSRSATVVIAYLMQQHNISPSEALSHVRQARSICEPNPGFMDQLNLYAQMHTPPDIESTPAYQRWVYQREIELSRACGQAPDADKIRFEDEHVADEAAAFELRCRKCRRALATSQYLLSHGSSFTAKDDEAEVPTSAKCAHYFLDPLSWMRPELEQGKLDGRLECPKCHTNVGKYAWQGMQCSCGDWVVPGISLAKGRIDEARKATFGIRRPPGASGPPAVGDSHPKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2QYR8</accession>
    <name>M2QYR8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_126493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Han J."/>
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        <source>
            <dbReference type="EMBL" id="EMD64434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="493" mass="55659" checksum="D5085CF4F0181585" modified="2013-05-01" version="1">MSLGIYASSGTPTIYTMTTTKPLKVLYFDGQAASLTHWGTLDSQMALLKNKVPDNPSERLVFDEDQRARELCTLLKSLSIDGTVRMNAGFEVLICDYVAAGVRQVHVSNITVPGNMEREHDPSLPRDPNRVPPLGYGNEFAPQNSWEWIRSGTWHYGTGEAVPGGNKETRVSLDLCGFITYYDPFLRSLSGHHHSQQDVLYQNGWGLRRGHRLLGISADDIGTVKSWLKQITALGKQDCSGIDWQALTETIVKQHGTRAREMLATVRHAVKDNNTMQEALTKVHELTHAVLYTYLEYPTAVGISPAAAKKETISRCSRIYTDHVDSNRLNDFEVIIRDSIQVLMHKLCSWEFDLFALSDRYTSDLFDPKHELVASSELVSKTSVRAAFDYIRTSTEELMEWIGWDSWHGCEHRCAFNELCYIPMWPVIYAPGKHQGGIFADDSYTEAEMSEFWRPKCINRTLFDQGGGRAREPSHQLPDVPSHLPTSKLMIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJV3</accession>
    <name>M2RJV3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_110311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696749.1">
        <property type="nucleotide sequence ID" value="XM_007698559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RJV3"/>
    <dbReference type="STRING" id="665912.M2RJV3"/>
    <dbReference type="GeneID" id="19130119"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_110311"/>
    <dbReference type="eggNOG" id="ENOG502S8RU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086132_1_0_1"/>
    <dbReference type="OMA" id="YPEWLWR"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD66974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="237" mass="25676" checksum="AA2E02261B9276C6" modified="2013-05-01" version="1">MICRSCLRAASRSAHQIPPVSLRRPQNPRFFTTASPLRNATPISSSTATQSKPRQGDLSSPHAPPTATSTSAAQPFSEPLTPAPGPDVKAAAAEAAKKKVAPLIKSSIPAGHPLKGLNFLKDRQDPIAAPDDEYPAWLWTLLDRQEKKAEKGAGDLFSKSKKQRRLAAKRLRKEQAENPEMMIPKVPLYEQTIDLPAGDGTLSGAVQAAEARDELTKAMRNKRRASIKEANFLKAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2RMG8</accession>
    <name>M2RMG8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_293625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697378.1">
        <property type="nucleotide sequence ID" value="XM_007699188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RMG8"/>
    <dbReference type="STRING" id="665912.M2RMG8"/>
    <dbReference type="GeneID" id="19136035"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_293625"/>
    <dbReference type="eggNOG" id="KOG0658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="OMA" id="MKTTMPM"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="398" mass="45563" checksum="83611CA0D5E65412" modified="2013-05-01" version="1">MSQNRPSAFSSLRMGEVIREKVQDGLTGDYKDLAYTQCKIVGNGSFGVVFQTKLSPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFFYNNGERPQKDEVYLNLVLEFVPETVYRASRYFNKMKSVMPILEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPSTGVLKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTRDQIRTMNPNYMEHKFPQIKPHPFSKVFRKADPSAIDLISKLLEYTPTQRLSAIDAMVHPFFDELRDPNTRLPDSRHPNGATRDLPELYNFTHHELSIAPHLNSQLIPPHHRATLAARGLDFESPSFKPLTKDQMMARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2RNY4</accession>
    <name>M2RNY4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_271785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695977.1">
        <property type="nucleotide sequence ID" value="XM_007697787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RNY4"/>
    <dbReference type="GeneID" id="19135630"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_271785"/>
    <dbReference type="HOGENOM" id="CLU_2454588_0_0_1"/>
    <dbReference type="OMA" id="CNWRRIM"/>
    <dbReference type="OrthoDB" id="10474426at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="89" mass="10171" checksum="0ABBF6FDE139FB81" modified="2013-05-01" version="1">MIAGLSVDMRIDRSCLSGRVRSARCSGGVEKGHVRDRRRRCRNRDAVARFEARRLVRICYVLESVKNECNWRRIMGVFALSFTGIVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RPK0</accession>
    <name>M2RPK0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_46957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695636.1">
        <property type="nucleotide sequence ID" value="XM_007697446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RPK0"/>
    <dbReference type="STRING" id="665912.M2RPK0"/>
    <dbReference type="GeneID" id="19140222"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_46957"/>
    <dbReference type="HOGENOM" id="CLU_000134_45_11_1"/>
    <dbReference type="OMA" id="NAQSEQY"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="77" mass="8458" checksum="50EEF19BE81E1C92" modified="2013-05-01" version="1" fragment="single">YGNTLYAASIEGHEPGVKLLLDMGADVNAQSEQYNSALQAASFRGYDQVVRLILDADADVNAWSEQYSSAFYASYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQ97</accession>
    <name>M2RQ97_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_157151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="10"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696275.1">
        <property type="nucleotide sequence ID" value="XM_007698085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQ97"/>
    <dbReference type="STRING" id="665912.M2RQ97"/>
    <dbReference type="GeneID" id="19131811"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157151"/>
    <dbReference type="eggNOG" id="KOG1661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_0_4_1"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000235">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="222" mass="23787" checksum="877468342D705DCD" modified="2013-05-01" version="1">MAWQSSGDTNEALVTNLASNKLIKSDRVKDAMLKVDRAHYAPSSPYEDSPQPIGHRATISAPHMHASACESLLDYLKPGSKVLDVGSGSGYLTAVLANLVAPNGTVTGIDHIQPLNDLATANMSKSDQGRRMLESGQVKFVTGDGRKGWAEGAPYDAIHVGAAAAEHHQILTDQLKAPGRLFVPVAEGWAQHIWVIDKRADGSLERQKLYGVQYVPLTDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQU2</accession>
    <name>M2RQU2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_52399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694403.1">
        <property type="nucleotide sequence ID" value="XM_007696213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQU2"/>
    <dbReference type="GeneID" id="19140292"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_52399"/>
    <dbReference type="HOGENOM" id="CLU_1964740_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="127" mass="14482" checksum="43D2ED36DC7BBF6C" modified="2013-05-01" version="1" fragment="single">MPNGSLKYNQPELAKVAKVAEQVETLQKQWQEKATLWASETDPYPPEVTNDKKKLKALRECTSTYIPPHMRTELIKTLHESPEYGHAGVDEIVRRLAKVFTIPRLRAKLPRSLEPGSARFCDTILVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RR84</accession>
    <name>M2RR84_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_340865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694513.1">
        <property type="nucleotide sequence ID" value="XM_007696323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RR84"/>
    <dbReference type="STRING" id="665912.M2RR84"/>
    <dbReference type="GeneID" id="19137443"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_340865"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="OMA" id="TESYNCA"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="365"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="592" mass="67603" checksum="1B6D19441C5591D3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRD2</accession>
    <name>M2RRD2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_31884</name>
    </gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <accession>M2RTL5</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="473" mass="52776" checksum="16DD46672090B070" modified="2013-05-01" version="1">MAHPNLRPETPNHTPSPVYIQTSPPGYACIHPTALDPAYNGPARPPSPVVVTTPAVSINSTTAVGFVANHTRSFTPHSNTDDCPICLDSYTTEACLQITGITGCNHRIGSMCLQKMLDHHPGDEKKCPMCRTVWISGLAPNFAAQDRSLANIRAMRNMLRDRGGESSSSHNRLPPGYTAYPIMTTDSQGVVRTYIQPSSLWQRRYQSVLIDSSEEEEEDYATQVRNYEDLTAHIADIRRRADNLVADRTNRNRRQGRLQHGHEESQSGSGSETNRVESRRRRGAISANTPGANPLNRFMNVRALNAFRTAVNGTAPEVAARGDRFTGHIMRGMARARDEPSPRDGQHRATPGEGLMMAGQQQNTVSSAGTPASPNLQTRTRRPGADFGVTGPRSGIPQPHTRISQSFRSPEARAQYLDERERFLDVRYTNLLRWETALQERETRAENTLALITRQRSELEEMMRRQREESDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2RVP0</accession>
    <name>M2RVP0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_193940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704918.1">
        <property type="nucleotide sequence ID" value="XM_007706728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RVP0"/>
    <dbReference type="STRING" id="665912.M2RVP0"/>
    <dbReference type="GeneID" id="19133871"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193940"/>
    <dbReference type="eggNOG" id="ENOG502SV8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055859_5_0_1"/>
    <dbReference type="OMA" id="GTICCAL"/>
    <dbReference type="OrthoDB" id="3695367at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024796" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32299" checksum="4A6CE965FFEE0BE8" modified="2013-05-01" version="1">MMLPRFLLVISQIASAAGYCYSRNGTTLLNAAFQPCKSTTKYSACCMTNHSGAGDIGIADDVCMENGLCQNYAVYNGNNEGEQVWSRQGCTDPLWNSPYCLGDVCNKPEYADKWGNVGVHNCGGKNWCCGEKTCCGDKGKIFELAATVGPTSILSSATPLSSVTPASSATTSSASMPTSSSTSKGDISSGGLSTGVQAGIGVGVAIFGIVVAAIAWLISRSIRSSGGKDSPSDGSTLHTDVSQAEKQPLHVHAHELRSTHGYGELGHRENAELAAINLPQELEARRQNVHQGIRVPEAQSETYHFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RWK7</accession>
    <name>M2RWK7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_203843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705161.1">
        <property type="nucleotide sequence ID" value="XM_007706971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RWK7"/>
    <dbReference type="STRING" id="665912.M2RWK7"/>
    <dbReference type="GeneID" id="19134278"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_203843"/>
    <dbReference type="eggNOG" id="KOG3064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050888_0_0_1"/>
    <dbReference type="OMA" id="DKGQNFC"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="340" mass="39093" checksum="4E6F860089C6EC71" modified="2013-05-01" version="1">MASDDLVWSIIGTDFCSFKLKTTKDQTFCRNEHNVSGYCSKQSCPLANSRYATIRSDPATGNLYLYIKAIERAHLPSQWWEKIKLPKNYAQALELVDQHLAYFPKFLVHKNKQRLTRLTQVNLRIRRLAKEEERLGERLVPRLAPKVRRREEGRERKALAAAKVERAIERVLIERLRSGAYGDRPINVEPNVWKRVMRGLEKEGQLKGDQDLDDGIEDEDEENEYEQEMENGVGEVEYVSDIEGESDDEMEDFEDWIGGQSPDDGTSGEDEESGSDEEEEDVSEDEDTAALKKTLANLKRKRPAGPPPKPKKKPSKDSKGPKRKIEYEMERAPTREAMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2S0A0</accession>
    <name>M2S0A0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carbohydrate esterase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_193323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703969.1">
        <property type="nucleotide sequence ID" value="XM_007705779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S0A0"/>
    <dbReference type="GeneID" id="19133845"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193323"/>
    <dbReference type="eggNOG" id="ENOG502S2CW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_11_1_1"/>
    <dbReference type="OMA" id="MHETYSS"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF9">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025334" evidence="7">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="45"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD60678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="252" mass="26690" checksum="76CE5E12469C9E6B" modified="2013-05-01" version="1">MGLKSLLVAALATVAVATPIPDPLNVIRQSGPAAGQVITKCVAPGQIALAYDDGPSQLTQQLVNTLNAGGAKATFFVTGTLYGCIYNQRNALQNAYKSGHQIASHTWTHPQNFGSLSSNDLTSQMSRLEQALVNIIGVKPTYMRPPYLATGGNVLPTMRNLGYRVITADVDSEDWNGKTPQQSQQKFQQAGAGGNGHITLMHETYSSTVNTLTPWLINWAKNNNLKLVTVAQCLGDSAGAYKSGTPNGAGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2S170</accession>
    <name>M2S170_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_124329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703353.1">
        <property type="nucleotide sequence ID" value="XM_007705163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S170"/>
    <dbReference type="GeneID" id="19130590"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_124329"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OMA" id="AHRCEIT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000093">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD61003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55411" checksum="5DD9D452562109C5" modified="2013-05-01" version="1">MAIPSTPSLVLLTIGLVVAKFLYVGLTCPTRHLPGPWYTRFTHYRLKRAVVTGQRIFYIDSLHEKYGPIVRLSPTEVGVADLDAFKEIHKIGTKYMKSEWYLRLANFPKAGVFTMLDPREHGPRRKLLSRSFSRSYLVQYWEPIVKEKALLAVQKIKADAVKSTADVYNWWMLLASDVSAHLAFGDSFGMLEDGRTNQFMRVLKKLTMGAGIMVEMPLLRLLRFIPITAIQEMFNANEFILQGAGKAVETARSRTGENNIFAKVIEDCEKEGEGHIDDMDVRIEAMNVIIAGTDTTGVTLTYLTWAVLQRPELQTALETEVGRLQDDFTENDLINLPLLNAVIEETLRLYGAAPSSLPRVVPQGGTKFAGHFIPEGVTVDTQAYTFHRDPEIWSEPLTFNPQRWIPDKETGVAEALSPAAKLAFHPFGAGARSCIGIHLARMELRYACAFFFRECQGIRLGERTTPESMEFENFFLIAPKAHRCEITFSEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2S2F6</accession>
    <name>M2S2F6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_173721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703821.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2S6E2"/>
    <dbReference type="GeneID" id="19141519"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_93685"/>
    <dbReference type="eggNOG" id="ENOG502SNQY">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
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    </dbReference>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="427" mass="48121" checksum="1B3F9B46DB9B2F49" modified="2013-05-01" version="1">MSSPQDRGSVLDSSSSDSPTLSDCRNESIAPLPRRPIPRKGHTKSRRGCYSCKRRRIKCNERHPECSHCLKAGLQCEYPANIIQATQRSHAISGPRETGNFRPAPGVFSMGDMRLFHHFLITAYPHLPVGQDKIWVTVIPSFAHNYEYLIHSILALSASHLDAVTSSGVAEQAIQHRILAVKSLNEALSVPPKTRCERDARMAAALALAFQSTHLQDGMAEFLTMVRGCNLIAGDEMSLNEDSVFHVFREDNHLQTIRNRINTSSMSCVNQEDLDIASVSLSSIESLYMSDCERSYWEHLASVVNHAYERPIDAYTAFVTLYNIPSRWTHEQFQAFIDPNNNVAQILLAHFIAIQAILTPILYLERVGFQGVNAPTAVLGWIEGIYWNVAHHLRHYVEWPRQVSKYPFGRFMGQKLSDNPDIDPNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6N4</accession>
    <name>M2S6N4_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_27300</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19135660"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_27300"/>
    <dbReference type="eggNOG" id="ENOG502QSY9">
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    </dbReference>
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    <dbReference type="OMA" id="EPPEWRG"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="867" mass="96040" checksum="3E4E858FF5C8C7E5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2S776</accession>
    <name>M2S776_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_37855</name>
    </gene>
    <organism evidence="18 19">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701014.1">
        <property type="nucleotide sequence ID" value="XM_007702824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S776"/>
    <dbReference type="STRING" id="665912.M2S776"/>
    <dbReference type="GeneID" id="19139108"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37855"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OMA" id="RRVTDNC"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000006">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000011">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="249"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD62978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="451" mass="50056" checksum="77EB077A36C4DB12" modified="2013-05-01" version="1">MRGEICHLHIGQAGTQLGNSAWELYLLEHGLLPDGRPNPDAKELGENGSYETFFTETGSGKYVPRSIFVDLDPSPIDEIRTGAYRQLFHPELLISGKEDAANNYARGHYTIGKEMVDSVIEKIRRVADNCSSLQGFLIFHSFGGGTGSGFGALLLERLSTDYGKKCKLEFAVYPAPRVSTSVVEPYNAVLSTHSTIENSDCTFLVDNEAVYDICRRSLDIPRPNYEHLNRLIAQVVSSITSSLRFDGALNVDLNEFQTNLVPYPRIHYPLISYAPVISAKKSSHESFKVSDLTFQCFEPNNQMVVCDPRNGKYMAVALLYRGDIVPRDCSAAAGALKAKSSFNLVEWCPTGFKLGINYTKPISVPGSELAAVDRSVAMLSNTTAIAEAWSRLDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVANDSLDDEGVEEGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M2S995</accession>
    <name>M2S995_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_144463</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700893.1">
        <property type="nucleotide sequence ID" value="XM_007702703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S995"/>
    <dbReference type="STRING" id="665912.M2S995"/>
    <dbReference type="GeneID" id="19131313"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_144463"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_12_1_1"/>
    <dbReference type="OMA" id="MCRVRPP"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Salamov A.A."/>
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2S9U3</accession>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699885.1">
        <property type="nucleotide sequence ID" value="XM_007701695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S9U3"/>
    <dbReference type="GeneID" id="19140195"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_44523"/>
    <dbReference type="eggNOG" id="ENOG502SYDX">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084654_0_0_1"/>
    <dbReference type="OMA" id="MAKSIHT"/>
    <dbReference type="OrthoDB" id="3778423at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="188" mass="21922" checksum="5CF2AA8876433BFA" modified="2013-05-01" version="1" fragment="single">NGLYFQNMVDAKAVMNNVQWRAPVFDSTIPQTDKDHQDVVRKLLWAFKDMSMAKDTAENAYRKRLTLGEASYYQDWAIEACAWDIVRMAKSIHTDGFRAPIYDKNLVNYIGQTQEWTFEERIDWICTKNEKAWNIVGAPHKMYQSTLTNTIANANRGAWVKSGRQADTEHQARVNKRRKTIHFSDDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SA05</accession>
    <name>M2SA05_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_357023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700006.1">
        <property type="nucleotide sequence ID" value="XM_007701816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SA05"/>
    <dbReference type="STRING" id="665912.M2SA05"/>
    <dbReference type="GeneID" id="19138474"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357023"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_1"/>
    <dbReference type="OMA" id="PRDFKLC"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="40"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD64128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="429" mass="48053" checksum="457891AD6B8B3715" modified="2013-05-01" version="1">MSATPRRADPFKPAARVAGQRQDVWSIVNEAAAASPVQPIVNMGQGFFGYNPPAFVLDAAKAALDQVDCNQYSPTKGRPRLKKAIAHAYSPFFGRDLNPDTEVTITTGANEGMLSAFMAFLEQGDEVIVFEPFFDQYISNIEMPGGKVVYVPMRPPKEGATKTTSAAEWTIDMNQLEAAITPRTRMIVLNSPHNPIGKVFSRAELQAIGDLCVKHNILILSDEVYDRLYYVPFTRIATLSPEIAKLTLTVGSGGKNFYATGWRVGWLIGPEQLIKYVSAAHTRICYSSVSPLQEATAVGFEQADAHNFWDDSKKEMKAKMDKFTAVFDELNLPYSDPEGGYFVLVNMSKVKLPQDYQFPPHVAERPRDFQLSWFLIKEVGVAAIPPTEFFTPENAYIVEDWLRFAVCKNDDVLERAMERLRSLKKYIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCI7</accession>
    <name>M2SCI7_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_316874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699526.1">
        <property type="nucleotide sequence ID" value="XM_007701336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCI7"/>
    <dbReference type="GeneID" id="19136497"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_316874"/>
    <dbReference type="HOGENOM" id="CLU_2120886_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="114" mass="12832" checksum="0901247D1BD1696A" modified="2013-05-01" version="1">MVDCMVKVGLGLQHYSLHDHISNTPFFLFFSDSLDMFAALAYLCFFLSSCLSWFAWGLLTCGGMLPFPTLYCVALNMFLPSCGGEKQPWKYILLIPRLCLDMAMVIAMLIQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCR1</accession>
    <name>M2SCR1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_250542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704438.1">
        <property type="nucleotide sequence ID" value="XM_007706248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCR1"/>
    <dbReference type="GeneID" id="19135204"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_250542"/>
    <dbReference type="HOGENOM" id="CLU_1927425_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="131" mass="14232" checksum="375B57B9AB2C28B6" modified="2013-05-01" version="1">MFALGMMLIVTSICVTVPILYSVGTMGTIKALAAVSLVAANVKAALSSTGFTISMSDIDYFLPPRPVAKIFRCKETQTLFDDAPFVPFTVVKGDDSVMDVASLTIGYADDDVWQEGFMQGTYFIEHLQLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCU8</accession>
    <name>M2SCU8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_98508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703694.1">
        <property type="nucleotide sequence ID" value="XM_007705504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCU8"/>
    <dbReference type="STRING" id="665912.M2SCU8"/>
    <dbReference type="GeneID" id="19141797"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_98508"/>
    <dbReference type="eggNOG" id="ENOG502SP2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057752_5_2_1"/>
    <dbReference type="OMA" id="FYHMDYL"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="285" mass="31621" checksum="7CA6FAD4825FE40F" modified="2013-05-01" version="1">MDAPMIELKSALASLFQCGQYSDLTIVCGAKRYQVHRILLATRSTFFEGACRGGFREAESGVIDLSEDDAEAVEHMIHYFYHMDYLSKKPLSRRSSQRSNRPTSLRQRQTPSRKFILDPSDDPLLALVAAAAPVTPPSNEPTFQNVDASAKLAATPMVDQILEDDDLESIESEPESEIQSAHLVAHAKVYAIAEKYGIAGLKTLARSKFVDQINLHLASPEFPEACQEAYESTFHSDRGLRDVIIQVFRANPSLSLRPDVEMMVRETPGLAFELFRMASGLPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDA3</accession>
    <name>M2SDA3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_158951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698478.1">
        <property type="nucleotide sequence ID" value="XM_007700288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SDA3"/>
    <dbReference type="GeneID" id="19131930"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_158951"/>
    <dbReference type="eggNOG" id="ENOG502SN0B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040205_0_0_1"/>
    <dbReference type="OMA" id="ECHDASH"/>
    <dbReference type="OrthoDB" id="3692147at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="421" mass="48866" checksum="C294AF72C4072A31" modified="2013-05-01" version="1">MLSFLRRIKRWREERKLIESVEKQDNQIAQTPLVALNHEESEFIKNVKERNNQQAQELLAALHNLQYTMDPLISAKVYNIRFRPLTSRLPDELLLCARLRRKPHCYACDSLHSVYEFSSEYQQSSSHQPERRCPGQQGSVKLYKHIQINWASIKAHIDDWRRQQLYRGGDWQACLDNFNIECHDASHDISCKASDEPTWPRARLSTISIDSISPGTVVLSIEWAPHSRIGTMDLTADGRIPAPELRSPFQRLRGLGPANTLYPASHLGDSPEMAFFDPLSHRRHFVHYQNGDDDQTRPLPPPPLYLPFQKRMSLELLLILQRGLHGKKLDMELHSLRNDGDTSISSYYLTLHYKTDIIVCKVMDLADPTVKIVPTDCWLHAMDTQTYPQASHVKPQCRNIACVNYFKRRKGRHYCEGRYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDU3</accession>
    <name>M2SDU3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_244969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703931.1">
        <property type="nucleotide sequence ID" value="XM_007705741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SDU3"/>
    <dbReference type="GeneID" id="19135094"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_244969"/>
    <dbReference type="HOGENOM" id="CLU_2399495_0_0_1"/>
    <dbReference type="OrthoDB" id="10355402at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="112" mass="12709" checksum="89C860F023F4546D" modified="2013-05-01" version="1">MRVWRDFRYTLFLLFLCSSLQAPTWWVGVVFFWRGNARLGTLTYVGVLSLPPPPATVDAEKQAFSRYCHGSLNVYVCGCVGRKWLDGDCIHGGVDARNYVLTTLLYLQKSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEJ1</accession>
    <name>M2SEJ1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_159314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698761.1">
        <property type="nucleotide sequence ID" value="XM_007700571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SEJ1"/>
    <dbReference type="GeneID" id="19131953"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159314"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_2_1"/>
    <dbReference type="OMA" id="NCIARHY"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD65683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="635" mass="69030" checksum="071B9F89BCD0FC57" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEP5</accession>
    <name>M2SEP5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_149247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703295.1">
        <property type="nucleotide sequence ID" value="XM_007705105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SEP5"/>
    <dbReference type="GeneID" id="19131484"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_149247"/>
    <dbReference type="eggNOG" id="ENOG502SS3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="OMA" id="MDWSLPC"/>
    <dbReference type="OrthoDB" id="3557394at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Salamov A.A."/>
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    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
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    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702657.1">
        <property type="nucleotide sequence ID" value="XM_007704467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SGI9"/>
    <dbReference type="GeneID" id="19140211"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_46028"/>
    <dbReference type="eggNOG" id="ENOG502SMHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_1_0_1"/>
    <dbReference type="OMA" id="WETRSSE"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD61535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47816" checksum="2D066A3D5AD42EAD" modified="2013-05-01" version="1" fragment="single">RELLSKGRKLYPNQPFQILTHGGPKIVLPQRYLEEVRDSQQASFPPYVMSETPWNLPGFDGLMVSHKHAWLLREVISVKLTQSLGVITESLAEEGILVAEELFGNLAPGRWHTVTLLPEVTKIIGRFTARTMLGEELAHNPEYIDISIKYGVTALPAALQFRPWPRILWPIVQYFNPLCKTARCQVQRARQLITKEVERREKLARAAIAAGTKVPKTHDSVAWVLDQSKNKTDQKLDLVGFQLTISMVAIHNTGGHLFTALWCLIAYPKYIPLLREEAISVLKEYGWTRQALAQLKLQDAVHKECLRILRSNLSTARRQVVKGNLTFSDGFTIPNGRRFFVMPPADYQGENEEFYPERWLKKREGEGQANKYSFVTANLENPEFGIGKHACPGRWFANDEMKIALCILLLRYDWKATPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SH49</accession>
    <name>M2SH49_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_39439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702648.1">
        <property type="nucleotide sequence ID" value="XM_007704458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SH49"/>
    <dbReference type="STRING" id="665912.M2SH49"/>
    <dbReference type="GeneID" id="19139496"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39439"/>
    <dbReference type="eggNOG" id="KOG4089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086423_0_0_1"/>
    <dbReference type="OMA" id="HWFREDS"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="217" mass="25918" checksum="7078FF7027AA79E0" modified="2013-05-01" version="1">MDAVPISKKLIAFGSKKIYLPKFTVALVRTPKLSPYHARFLVPLDFSKYDLRDYLYHAYNVRCFNIRSYVKQMPVRDTREQPRHWFRPESQKYMTVEMEQPFVWPEIPDLEPWGQREKQNEVEEASRTNGAIDNNDKREAARKLREQAKKLLYKDVGRHGERSQLSEEVDAQDSEAQVEREREERMLNRMSRIKLWEKERTGKAVESDNRKHYAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SI77</accession>
    <name>M2SI77_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_192127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702394.1">
        <property type="nucleotide sequence ID" value="XM_007704204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SI77"/>
    <dbReference type="STRING" id="665912.M2SI77"/>
    <dbReference type="GeneID" id="19133790"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_192127"/>
    <dbReference type="eggNOG" id="ENOG502ST13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676432_0_0_1"/>
    <dbReference type="OMA" id="AIFRFHY"/>
    <dbReference type="OrthoDB" id="5309154at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="444" mass="49761" checksum="621C86F231758970" modified="2013-05-01" version="1">MKATEEGSDRSAEMSICIEGSANPLPEYGEYVDPVDHAICSYVPLEKGQKPKFSGKFKGTTLDIVCDALMDGIHRKYYSYGARAVRFQKSKKIEIDKFLFKTEDGVIDSQMVVSTLGMATTQSDLPETIGTMELRLYCTRKIGVSHEVKGVKQYYTEDNRKQNNEDNSTSNNDDNQKPENSKKGSEKTNQIVSYRQVAPTSQLDIERDSAPISEQAIASYYNKMVPSRPGKEPWAIFRFHYRSKEALESSGVVCDPKDKKPTSARVLSFLEPVPPLIVETKCHPRTPAASEEPFSKASTPIETKPESLADPAVTTMTPVAESTISTTSESGAKRLSATINETLPEAKRPKVLPPSPSTKANSLKSQLAERRKKLAELYKNHCQEAETLATIQRKIEPYEQRMMEELERINQEITGEETALKDVLERRSHFEKVLQEFEDGQDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJE4</accession>
    <name>M2SJE4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_83310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696999.1">
        <property type="nucleotide sequence ID" value="XM_007698809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJE4"/>
    <dbReference type="STRING" id="665912.M2SJE4"/>
    <dbReference type="GeneID" id="19140950"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_83310"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012437_1_2_1"/>
    <dbReference type="OMA" id="ECSHEYT"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="610"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="620"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="662" mass="74408" checksum="6914386A23A8FD5E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJN6</accession>
    <name>M2SJN6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MTHFR SAM-binding regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_136346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697066.1">
        <property type="nucleotide sequence ID" value="XM_007698876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJN6"/>
    <dbReference type="STRING" id="665912.M2SJN6"/>
    <dbReference type="GeneID" id="19131008"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_136346"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_2_1_1"/>
    <dbReference type="OMA" id="GLMPINS"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="405"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD67398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="653" mass="73159" checksum="2324EBB191923A2D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJY7</accession>
    <name>M2SJY7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_201228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701948.1">
        <property type="nucleotide sequence ID" value="XM_007703758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJY7"/>
    <dbReference type="STRING" id="665912.M2SJY7"/>
    <dbReference type="GeneID" id="19134184"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_201228"/>
    <dbReference type="eggNOG" id="KOG2774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_19_0_1"/>
    <dbReference type="OMA" id="HWHASPR"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="303" mass="32611" checksum="1DADF47EF501D924" modified="2013-05-01" version="1">MENKQYILITGAGGFIADVFEPPCPDASRVVTSKADLTQSSAVDSLLCSQTWSACYLLHGIMSGGAEANFDLGLIVNVDSHRLILDYLRRNQPGVIVVFPSSLTVYGPPDPSSSFISERTIPIPQSSYGAEKLIVETLINDYSCRGLIDGRICRLPTVIVRPGAPSAVASSFASGIVREPLKGESSVVPVSMDLEMWVCSPKTVVRNLVAIKDVSAENFSSNHGRTVNLPGQTVKGGQILDALMEVDGREALALVEEKRDLKVEAIVASWPARFDIALAESLGMSRDISLTEEVERFAKSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKS7</accession>
    <name>M2SKS7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_92811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701206.1">
        <property type="nucleotide sequence ID" value="XM_007703016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKS7"/>
    <dbReference type="STRING" id="665912.M2SKS7"/>
    <dbReference type="GeneID" id="19141471"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92811"/>
    <dbReference type="eggNOG" id="KOG0037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051357_0_1_1"/>
    <dbReference type="OMA" id="YNKSYNP"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
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        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
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    </feature>
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            <end position="286"/>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_269886"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
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</entry>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445656">
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    </dbReference>
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    <dbReference type="GeneID" id="19134288"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_204361"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025943" evidence="2">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="156" mass="16872" checksum="70F059901DF82495" modified="2013-05-01" version="1">MQYRLVSMLAAGVLVAMSSAAPVPSPDNLSITNPPNTIELGKPSSEISWGRSVDTEVTNPDVVDISPPTSEIIWSKEKKARGVEFEKPKDSFNLGNANTVVTWGKRDSTTGVTPEDTIELGKPSTEITWSKEKRDELVTPDDSISLGKPSTVVTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMP8</accession>
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            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
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        <name evidence="1" type="ORF">COCSADRAFT_53840</name>
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    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445784">
        <property type="protein sequence ID" value="EMD58052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706247.1">
        <property type="nucleotide sequence ID" value="XM_007708057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMP8"/>
    <dbReference type="GeneID" id="19140303"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_53840"/>
    <dbReference type="HOGENOM" id="CLU_204930_1_0_1"/>
    <dbReference type="OMA" id="FDTCINR"/>
    <dbReference type="OrthoDB" id="3935025at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="5959" checksum="095D2DE75A829A47" modified="2013-05-01" version="1" fragment="single">ATGAILKKPSKPDYSTPKAYRVITLLSCLGKVIERIIAKRLSYLAETTNLLHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMY1</accession>
    <name>M2SMY1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_103200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705622.1">
        <property type="nucleotide sequence ID" value="XM_007707432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMY1"/>
    <dbReference type="GeneID" id="19129830"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103200"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OMA" id="CDGMMEV"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF26">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY OXIDOREDUCTASE (JCVI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="248" mass="26828" checksum="96D5B8651C594FDC" modified="2013-05-01" version="1">MASTTVLITGANRGIGQGLTECFLAEANHTVIAAVRNPEHPTVQKLQELPKDPDSQLIVVKLDASVEEDAKNAVTELQQKHGIDHLDIVIANAGIGYIYPTVADVKISDIKAHMECNVYGVIALYQATRDLLKKSSREPIFLPMGSSAGLLINHLPIPNAAYAPTKTAINWYTIRINDEDEWLNCFTIDPGHVSTDLGDGAAVAVGIGEKAPLSVQDSCEGMMKLFARATKKEFGGKLMVYTGKVSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN27</accession>
    <name>M2SN27_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_178363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696131.1">
        <property type="nucleotide sequence ID" value="XM_007697941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN27"/>
    <dbReference type="STRING" id="665912.M2SN27"/>
    <dbReference type="GeneID" id="19133138"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_178363"/>
    <dbReference type="eggNOG" id="ENOG502QZJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011099_3_1_1"/>
    <dbReference type="OMA" id="EMTELSW"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="543" mass="60973" checksum="DF34DF25D2E26B5D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SND6</accession>
    <name>M2SND6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_103508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705716.1">
        <property type="nucleotide sequence ID" value="XM_007707526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SND6"/>
    <dbReference type="GeneID" id="19129849"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103508"/>
    <dbReference type="HOGENOM" id="CLU_2564579_0_0_1"/>
    <dbReference type="OrthoDB" id="10346434at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="82" mass="9539" checksum="C0CC8D5014594E07" modified="2013-05-01" version="1" fragment="single">TRDRTQKALGGKSRQSFSLPPVEHVLPRYIGAGTSTVSTMTRQARWISWAEVRRGVQKWVGMWVRERRKGYAQTEQIRQQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNP6</accession>
    <name>M2SNP6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_37658</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700482.1">
        <property type="nucleotide sequence ID" value="XM_007702292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNP6"/>
    <dbReference type="SMR" id="M2SNP6"/>
    <dbReference type="STRING" id="665912.M2SNP6"/>
    <dbReference type="GeneID" id="19139042"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37658"/>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026390_0_0_1"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="MnmG N-terminal" evidence="18">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="19">
        <location>
            <begin position="211"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD63930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="511" mass="55982" checksum="26324B78E1E0CC11" modified="2013-05-01" version="1">MYSGTKLTELPPGVSATHSPQLRKRGSSTQIAPTAQAIDTTDYREQRRRIHHEADVVIVGAGILGCAAAVAFGKQGRSVILLEKSLKEPDRIVGELLQPGGVNALEKLGMRDCLDDIDAIPCYGYQVMYHKEQAHIPYPDNLIKSAPSKAPEGRSFHHGRFISKLRAKAKATPNVTVVESTVTSLVKSDHTNQVVGVSCQTEGEQDYFFGAVTLVADGYASKFRKEYIPHQPQVRSKFWGLEMIDAQLPVPNHGHVILTDAPPILIYQIGTHETRILIDVPENLPSASPKNGGIKNHMLNVALPRLPECVQPAFRKAVEQGKLRSMPNSFLPPSTQKQAGLIILGDAMNMRHPLTGGGMTVAFNDVVLLSSLLSPANVPSLEDSEAVLAALGKFHWQRKNGTSVINILAMALYSLFAADNTYLELIKKGCFKYFLRGGASVAEPSGMLAGLITHPWMLVYHFFYVAVYAIYVRLAEVPFYMIPWTLTVESTMVIWTAVCVIGPYIIAEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPP0</accession>
    <name>M2SPP0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_90497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700115.1">
        <property type="nucleotide sequence ID" value="XM_007701925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPP0"/>
    <dbReference type="STRING" id="665912.M2SPP0"/>
    <dbReference type="GeneID" id="19141350"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90497"/>
    <dbReference type="eggNOG" id="KOG0881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="166" mass="18215" checksum="3A02FC9F59B365B7" modified="2013-05-01" version="1">MATDVALDTTIGTVVVELYNDHAPKTCKNFSTLAQRGYFNGLIFHRIIPNFMIQGGDPTGTGRGGESIYGEKFEDEISPQLKHTGAGILSMANSGPNTNGSQFFITLAPTPWLDGKHTIFGRVKSGMQIVKKLGLVKTDKEDRPVEEVKIVRAYIPDDNAQALQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ01</accession>
    <name>M2SQ01_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATP synthase epsilon chain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_102217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704979.1">
        <property type="nucleotide sequence ID" value="XM_007706789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ01"/>
    <dbReference type="STRING" id="665912.M2SQ01"/>
    <dbReference type="GeneID" id="19129786"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102217"/>
    <dbReference type="eggNOG" id="KOG3495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187039_0_0_1"/>
    <dbReference type="OMA" id="NKYTQIA"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8200" checksum="59A62AB0A3B79A16" modified="2013-05-01" version="1">MAFAWKAAGLTYNRYIAVASRVVRRSLKDDKRIAAERRGESELKFSKWENGKQGEVKDLNAAALQAQADAAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQH3</accession>
    <name>M2SQH3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_347929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705102.1">
        <property type="nucleotide sequence ID" value="XM_007706912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQH3"/>
    <dbReference type="STRING" id="665912.M2SQH3"/>
    <dbReference type="GeneID" id="19137871"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_347929"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OMA" id="FRILVNF"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="339" mass="36457" checksum="EBC822FAA3C2EB6C" modified="2013-05-01" version="1">MATNKSFAAETGGLEIAKAYSSQIIGKTVLITGVSPGGIGEATARAFAHGGASIIIATGRSKTRVESLTKEISADYPSTKFVNVVLDLASLKDVQRAANEILNDRSIEKIDILVNNAGSQFGNAERELTVDGIETHLAANYLGHFLFTKLLLPRLLAAAKVNPPGATRIIPVGSEAAQFSPFRFSNWNFDPDKELAADEKPNWDLITNMTGVPETTNFDAFVAYGQSKTAAPLFAVHLNTLFAKEGIFAFALHPGGVRSTAALAIIEAVPAYDKLFTKTIDQGSSTILMAAADPGLNPEKGVWLEDNQLAEPVTWAVDKEKAERLWKLSEKIITEKLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQL8</accession>
    <name>M2SQL8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_171633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700316.1">
        <property type="nucleotide sequence ID" value="XM_007702126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQL8"/>
    <dbReference type="STRING" id="665912.M2SQL8"/>
    <dbReference type="GeneID" id="19132752"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_171633"/>
    <dbReference type="eggNOG" id="KOG2773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018299_2_2_1"/>
    <dbReference type="OMA" id="INFMAPN"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="181"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="366"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD64575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="482" mass="53489" checksum="09E3EAAAAAFF0EA0" modified="2013-05-01" version="1">MKKSKTRDFDPESLLDPAPSSSEDERSGSDVSDVEDEKVGREHYTVVGKSKLRKPVEVPLGPEYTGRKVDRKALEDSDSDDPFARSFDDEDSEASDDEGEDDINGAEFDREDESGGSDADGGLDLDMSDEDEENEEDEEDSEAEDEDKPDKDKKPDASAVRDLMVASKSFTSTIAAGTQSDVAKGEAVKTQRKTFDTLLNSRIRLQKALISTNSMAAEPYRDETAQEAPVEAAEAAALTLLNNLTNLRLSLEESRTGQKRKRANFDHATPSSEIWSTIQDTEKGTLPHRKAILERWSNKTKATTVTNNKARLNASAQQTLTEVLDSQLTSSHLVTRTQMPRSCAPLQSSNKAAQADPAIYDDADFYGLMLKELLEQRSADLNANGTAEFVVQAPWQVAREAKTKKVVDTKASKGRKLRYTVQEKLQNFMAPEDRGEWGDRQRDELFSSLFGQRLGLGEHDEVESEEEEQVDAEEAGLMLFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRV7</accession>
    <name>M2SRV7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_180979</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699531.1">
        <property type="nucleotide sequence ID" value="XM_007701341.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SRV7"/>
    <dbReference type="GeneID" id="19133272"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_180979"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_4_0_1"/>
    <dbReference type="OMA" id="LFRVCNM"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000868">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001214">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
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        <location>
            <begin position="440"/>
            <end position="538"/>
        </location>
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        <location>
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            <end position="1021"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS51192"/>
        </source>
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        </source>
    </evidence>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSZ4</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_354572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="382" mass="43118" checksum="488CE5C07520DE8E" modified="2013-05-01" version="1">MWPAKIIPALFSALLWQAILPPAHVVDVVEVTTLVVQVTRVYSTITVTQTVGTPTTAIDHALPITTSTPLPPAARPMLGPYNYPPSNESLAHDQTSSTSLVLEECVYLLSSLAVPQYSVLDMIIGIFMATSLVLFVWKILIPLIKLRIRNLIRIWPRTMEFFCITVQVIFGLDEEDVLWAAWMTCYKYFLGCILRALCEVDQSVRMLFGYIQITKLSIQVVCMRCVIFAFQIFGVDLKKGKPNGWVTEERLAQAQSQSKPVLYQDSPNSLMLGNKCVGYRSTIMELVHDNNYFRLVLCSMLNAHYNIANGKQPNALDGDHPYRTTLIKFNPVADKKTGLYIGYKGGTLRREDTLNKVYCVNVESLAKRIEHEPHRMAAILQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2STH8</accession>
    <name>M2STH8_COCSN</name>
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        <recommendedName>
            <fullName evidence="8">Protein phosphatase PP2A regulatory subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_174683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD60401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705573.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2STH8"/>
    <dbReference type="GeneID" id="19132924"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_174683"/>
    <dbReference type="eggNOG" id="KOG0211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015533_2_1_1"/>
    <dbReference type="OMA" id="NRVEAMQ"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="277"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="581"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68388" checksum="2D97D0205A49A1C6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2SV69</accession>
    <name>M2SV69_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_149327</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703320.1">
        <property type="nucleotide sequence ID" value="XM_007705130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SV69"/>
    <dbReference type="STRING" id="665912.M2SV69"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="GeneID" id="19131489"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_149327"/>
    <dbReference type="eggNOG" id="KOG3342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_0_0_1"/>
    <dbReference type="OMA" id="ILMNEYP"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD60961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="173" mass="19104" checksum="E6F503A5596CA987" modified="2013-05-01" version="1">MFGVAGMQPRQLAAQVLNFALVLSTAFMMWKGLSVVADSPSPIVVVLSGSMEPAFQRGDLLFLWNRGLDTQIGEIVVYNVKGKDIPIVHRVVRRYGGGKTPLRLLTKGDNNLADDTELYARGQSFLNRKEDVIGSVVGFIPFVGYVTILLSEHPWLKQVMLGIMGVMVVLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVG5</accession>
    <name>M2SVG5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_163250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703208.1">
        <property type="nucleotide sequence ID" value="XM_007705018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVG5"/>
    <dbReference type="STRING" id="665912.M2SVG5"/>
    <dbReference type="GeneID" id="19132226"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163250"/>
    <dbReference type="eggNOG" id="KOG3486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167122_2_0_1"/>
    <dbReference type="OMA" id="AMDRLWQ"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD60822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="87" mass="9559" checksum="05ED4983B38ACB2B" modified="2013-05-01" version="1">MENERGELVDLYIPRKCDATNRIIRPKDHASVQIAIANVTAEGRAIPGDNKSFALAGFVRAMGEADDSLNRLAQQSGYLEKVWSAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVH0</accession>
    <name>M2SVH0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_34871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697514.1">
        <property type="nucleotide sequence ID" value="XM_007699324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVH0"/>
    <dbReference type="STRING" id="665912.M2SVH0"/>
    <dbReference type="GeneID" id="19137911"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34871"/>
    <dbReference type="eggNOG" id="ENOG502SEUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061239_0_0_1"/>
    <dbReference type="OMA" id="MQNNDCE"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026162" description="Cupin type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="64"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="236" mass="24752" checksum="9A7B3A70B453E26F" modified="2013-05-01" version="1">MTILTNLILLPLTLLTTLTTSSTAATLETPKSRTLHPELNAALRTAATSFDRAALLPNNADWTYDFTKHPNYDSPTGAVINADAATFPAVTGLGSSVALLKLAPCGMLPPHLHPRATNIVTAITGNTTTWMIGENGVGVRRVELLPMMVTVFPQASLHMMQNNDCEPSLLISSLNSDDSGTLNILPSLWSVPQDIIGAGFGNDAFNAADVGKDIPAVGTGAIIGSAECKKRCGIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWE5</accession>
    <name>M2SWE5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_24705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697450.1">
        <property type="nucleotide sequence ID" value="XM_007699260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWE5"/>
    <dbReference type="GeneID" id="19135137"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_24705"/>
    <dbReference type="eggNOG" id="ENOG502SXAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1133419_0_0_1"/>
    <dbReference type="OMA" id="DRDEFGF"/>
    <dbReference type="OrthoDB" id="3694586at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="267" mass="27430" checksum="3481E2CCA94C6920" modified="2013-05-01" version="1">MANFAHRVSYVVRDKDDDDDDPKPGPPPPKETESPQAVSAVPPTATESLANTAPSSTSATLPTPPTPGAPEAPGASGTSGTSGTSAASGASGTSAASGTPGYSEGSRSSGDSFGPAESAGIGVGVALALLFLALGAWFFIRRRRKRRLSKASLGSSTPDTEAGFANKEYGAPSIREMEAGRRASELAAHMGPVEVPGDPEFVAELEGSDAAIGAVAEKKDRERLFADAPLDEPGDRDEFGFSRNNSRRSDVKGAIDFKGSDVKKFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWH2</accession>
    <name>M2SWH2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_35152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697594.1">
        <property type="nucleotide sequence ID" value="XM_007699404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWH2"/>
    <dbReference type="GeneID" id="19138098"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35152"/>
    <dbReference type="HOGENOM" id="CLU_831928_0_0_1"/>
    <dbReference type="OMA" id="AKESDAC"/>
    <dbReference type="OrthoDB" id="3934095at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="PRICHEXTENSN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="330"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="123"/>
            <end position="138"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="281"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66645.1"/>
        </source>
    </evidence>
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        <source>
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    <sequence length="401" mass="43544" checksum="09CC3F5BE170D339" modified="2013-05-01" version="1">MADLDVLMDETLTLCKTPPVPRRHPYRQFYQYKKPETAAPAEKPDIDMIGPPMFTFGSETDLVPQPLFSRGNSMPSRSNSLPSASSRPVRPPEPFQFNSDIVKSPSPLFSRRNTLPPRVRRAMASERKPSPLSHREDAQPPEPTHHPSALMPPPTSPNEQPPTLSTITTTINTTTTTKPQPTLSKATPSKPKPLPPKIFQAIPPPTRPPPPVPTMATPSKPAPSKAIATKTTPSKPTPSTPSSLTASTPKRPSPLSGKGSVRRPGPSQFAPFQPASPMVLSPVTSHTSSVASSPTPSVFSEAASFSASAPSTPSTPASSPPSSPDNRPRSPMCYFTPTYWTIMTSPSPVYIPRQKLRRKDSPKIENLRTLRAKESDACLEAMYDQRTSAYMDWTGFQALSN</sequence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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    <dbReference type="HOGENOM" id="CLU_1077717_0_0_1"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
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    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="258" mass="29029" checksum="D5EE4D4E229DEB18" modified="2013-05-01" version="1">MYNTEFKYAQNGGRSFIQLRLALPVETAVNSGPFTICPKDTSNVEEHNIFSLDGAMLAFDAVNIDFSLSSDCNVYNPFVLHTSPPTPHPSLPPNLHPVREQILIPHHPALDALLWPSVREKLICVLHLSSHQRPPITHGTRGEPIQRLIHDIYDYSSGYRVHSNTAGWSPHHEMAEESCEEVNGIDLSRIMPGKGRRETLSNTALVNLSQRKKVGRRAIYLHSNLNLFKTLISSLLTANDQATNPAKHRTYSTMLRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY89</accession>
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        <recommendedName>
            <fullName evidence="5">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_95854</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007703988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY89"/>
    <dbReference type="STRING" id="665912.M2SY89"/>
    <dbReference type="GeneID" id="19141643"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95854"/>
    <dbReference type="eggNOG" id="ENOG502S808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056788_1_1_1"/>
    <dbReference type="OMA" id="FPIKNRV"/>
    <dbReference type="OrthoDB" id="5386133at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
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    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
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    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
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    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
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    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix-turn helix" evidence="2">
        <location>
            <begin position="28"/>
            <end position="72"/>
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    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="87"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31220" checksum="949DC4ABF6D58AE6" modified="2013-05-01" version="1" fragment="single">VGRSRSITPIMLQALCEHLLEKPDLYQEEIAVFLWDKFQTQVTVHSIGRALASVGWSKKATRRVARQRNADLRDFYLYKLSAFRSYQLVYVDESGCDKRIGFRRTGWSPVGVTPVQIAQFQREQRYQILPAYAQDGVVFARVFQGTTDAAVFEDFIEQLLCHCGRYPEPKSVIIMDNASFHHTERVEQLCRDAGVQLLYLPPYSPDLNPIEEFFAELKAYIKRNWNKYAENPMQRFDLFLEWCVDMVGARIPSAEGHFRHAGVTIESVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZI8</accession>
    <name>M2SZI8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_179327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697308.1">
        <property type="nucleotide sequence ID" value="XM_007699118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZI8"/>
    <dbReference type="STRING" id="665912.M2SZI8"/>
    <dbReference type="GeneID" id="19133189"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_179327"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_5_0_1"/>
    <dbReference type="OMA" id="WQYAGLG"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="463"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="814" mass="89855" checksum="13022191573903F4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1M0</accession>
    <name>M2T1M0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1776-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_172474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701337.1">
        <property type="nucleotide sequence ID" value="XM_007703147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1M0"/>
    <dbReference type="STRING" id="665912.M2T1M0"/>
    <dbReference type="GeneID" id="19132792"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_172474"/>
    <dbReference type="eggNOG" id="ENOG502QWSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022136_1_0_1"/>
    <dbReference type="OMA" id="HDVRRYS"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49421" checksum="0AF9E55E3C6F198B" modified="2013-05-01" version="1">MSNNDQQVLGVLAEYSRDVRNFTGSIWDATDAHFAHVAGYIKKSLPETWLPERARPRPPPPPPHPIAGAYLYRLQDWVLRHRALTAAIVAFCATGGFLVWQEQKRYNRKRRAKRAGNGARMEVVVLAGPPNSPIVRSLSLDLERRGFIVYIVCSNMDEEQQVLGESRADVRPLHLDVVDTMGTQEAMRRFNELLTKPHVAFSGATPHNLNLRGVVLVPDLIYPTGPVETVSPELWSDALNAKVLNTIAVTQALLPTVCEFKSRVLMLTPSIIASLRPPFHSVETTIVSALEGFLASLRGELGTLGIEVLQFHLGTFDLTNVGPKHHVQSRSIGSPHAWPATTRALYASNFEAQARVAQSHGLLNQSGSSVRELHNGVFDALTQRRPQKVWRVGRGSVTYDLVGNWVPRGLIGWMMGLKRVALDTASKPRLEDSVQLQCWEKVDAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2C2</accession>
    <name>M2T2C2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_182591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701533.1">
        <property type="nucleotide sequence ID" value="XM_007703343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2C2"/>
    <dbReference type="GeneID" id="19133366"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182591"/>
    <dbReference type="HOGENOM" id="CLU_135127_0_0_1"/>
    <dbReference type="OMA" id="LANLWGM"/>
    <dbReference type="OrthoDB" id="3683448at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="118" mass="13410" checksum="C3AD6CEC780838C2" modified="2013-05-01" version="1">MPRPPCAPVQYAMRRMPASLALDLASQHQATARDCDTDTQGYDENHPQPSAKRLLLRICFDLSALANLWGMTLRPQCSNSTKQIRLLSSPGGPRIHLKGPYRCRILHMLRQYDIEPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2Y8</accession>
    <name>M2T2Y8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_91745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700529.1">
        <property type="nucleotide sequence ID" value="XM_007702339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2Y8"/>
    <dbReference type="GeneID" id="19141418"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_91745"/>
    <dbReference type="eggNOG" id="ENOG502SG6V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025630_2_0_1"/>
    <dbReference type="OMA" id="YHYANSR"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023:SF6">
        <property type="entry name" value="LIPASE CLASS 3 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023">
        <property type="entry name" value="LIPASE CLASS 3 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="303"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="601" mass="66150" checksum="2E623C59E59E0C16" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T344</accession>
    <name>M2T344_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_23266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695384.1">
        <property type="nucleotide sequence ID" value="XM_007697194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T344"/>
    <dbReference type="STRING" id="665912.M2T344"/>
    <dbReference type="GeneID" id="19134808"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_23266"/>
    <dbReference type="eggNOG" id="KOG1679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OMA" id="YEQAHAW"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD68875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="297" mass="31854" checksum="AB984CC06E7B88D2" modified="2013-05-01" version="1">MPFLRPAPRILYRAIQTRTFATAQTPAINVKNIPAPHCGSIRILSLNRPAARNAISRQLLAELSHQVNSIHDEGDNGPTRALILASDVDSSFCAGADLKERATFTQEETANFLASLRGTFTSISQLPIPTISALAAPAFGGGLELALTTHMRVFGSTTTVALPETRLAILPGAGGTYRLPAVIGLSRARDMILTGRRVAAPEAYFLGLCDRLVEVTPEVAKEEGATRKKVLEEAINLAMNICEGGPIAIRAALAAVEGCALGEKAENAAYERVVRTKDRDEALLAFREKRKPVFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T454</accession>
    <name>M2T454_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700451.1">
        <property type="nucleotide sequence ID" value="XM_007702261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T454"/>
    <dbReference type="STRING" id="665912.M2T454"/>
    <dbReference type="GeneID" id="19139011"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37554"/>
    <dbReference type="eggNOG" id="KOG0005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="77" mass="8634" checksum="35A1EB258497F735" modified="2013-05-01" version="1">MQIKVRTLTGKEIELDIEADYKVSRIKERVEEKEGIPPAQQRLIYGGKQMSDDKTAADYQLEGGATLHLVLALRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4D4</accession>
    <name>M2T4D4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_356948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699988.1">
        <property type="nucleotide sequence ID" value="XM_007701798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4D4"/>
    <dbReference type="STRING" id="665912.M2T4D4"/>
    <dbReference type="MEROPS" id="M67.A10"/>
    <dbReference type="GeneID" id="19138470"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_356948"/>
    <dbReference type="eggNOG" id="KOG1555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052991_0_0_1"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD64101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="333" mass="37164" checksum="29D3DADD5D87E862" modified="2013-05-01" version="1">MDRLSRMLAAAQGMGGMGGPQADTNLIDNSETVYISSLALLKMLRHGRAGVPMEVMGLMLGEFVDDYTVRVVDVFAMPQSGTGVSVEAVDPVFQTKMMDMLRQTGRQETVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVVDPIQSVKGKVVIDAFRLINPQTLMMGHEPRQTTSNVGHLNKPSIQALIHGLNRHYYSIGINYRKTALEENMLMNLHKHVWTEALLMDDFKSEGERNVDRLQKLVTLADGYEKRVKEETELTKEQLKTRYVGKVDPKKHISDVGQQLIEDNIVSVSRQMIDKEASVPKPNARQSGHASGGDDVEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T589</accession>
    <name>M2T589_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_357063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700023.1">
        <property type="nucleotide sequence ID" value="XM_007701833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T589"/>
    <dbReference type="STRING" id="665912.M2T589"/>
    <dbReference type="GeneID" id="19138476"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357063"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OMA" id="QQMHLFS"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48804" checksum="1D604661A4D36B6E" modified="2013-05-01" version="1">MKEIPSDGFIIFRGIFHTTTLITTSTEVLADVFVHKSHNFGKPPLRKTIMRKIIGNSLATADSDEHRHMRKIIIPAFHFRNIRDLYPMFWAKLTEFCHALSKDFGERSDRVLEIGHYSTQVTMDMIGLGGLGRDLNSLQYSDDELVKIYEDIFEPMKKKVLYFLFHIFLSPWVVERLPRGLNKRLKVGRSRLRKICSDFVAEKKVKIKVESSGSQKSQDILSCTIRSNEFPDENLVYHLLTTLAAGHLWSEIYEYIPDPKVLLKSAFDVAGLLESMPCLNCVCNEVLRLFPTIPIIMRVVIRDTTVAGHHIPVGTTVYLVPWATNCHSTMRGPDAEEFVSERWIDKETGRPTMRGGAESNYSFLTFLHRPRSCIGERFARAELRALMAALVGSFAMELADPLEKVVAGGTITSKPVNGMRLKLQPVGLGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5T7</accession>
    <name>M2T5T7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_160775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700317.1">
        <property type="nucleotide sequence ID" value="XM_007702127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5T7"/>
    <dbReference type="GeneID" id="19132066"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_160775"/>
    <dbReference type="eggNOG" id="ENOG502S03T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069181_0_0_1"/>
    <dbReference type="OMA" id="QWYARIW"/>
    <dbReference type="OrthoDB" id="4436466at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="257" mass="28842" checksum="6671470FCB259E2F" modified="2013-05-01" version="1">MNTISPPPQIKRLSGPKRVLGILVGITGGLGANALLAYSVSSFYTRNTKFVPFDTSAPDLTTKTFRDHNPLNNPPACIDHAIKQVPYGKLPEKYWVKGSGGRISVDQKALATDFCRGIWSGVAFRVQRRIMERKYRALEGRQDHLWDVKDLEKSSYPVGTKIVDHFEVVEHTDDKVIVRCGDSPLNRNQRSSDGLFSMEVSKDDEAQMATFHLKSVFLDTSPEGKGTQPQPAPLQAAHRWYTKLWMESATRKLIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2T655</accession>
    <name>M2T655_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_215053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695099.1">
        <property type="nucleotide sequence ID" value="XM_007696909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T655"/>
    <dbReference type="GeneID" id="19134476"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_215053"/>
    <dbReference type="HOGENOM" id="CLU_1517622_0_0_1"/>
    <dbReference type="OMA" id="VTYRAIM"/>
    <dbReference type="OrthoDB" id="3693354at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="162" mass="18914" checksum="833B6E7A6E7CDBC6" modified="2013-05-01" version="1">MLSHYSTLFVNPKSQANQHRTQNNSLFFTKSNKNPKSTTKKPKDTHKTRDLVSRYLSSPRISSIFHPTRKPNPKSLLKPQNYSMGARCSPHKNTRGARSSTGQPEWYVTYRAIMDEEEKRVKRVRKEEDRAWEKEVRRDKEKYARDTLGKEGVFADVFVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8J6</accession>
    <name>M2T8J6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_303907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698486.1">
        <property type="nucleotide sequence ID" value="XM_007700296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8J6"/>
    <dbReference type="STRING" id="665912.M2T8J6"/>
    <dbReference type="GeneID" id="19136237"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_303907"/>
    <dbReference type="eggNOG" id="KOG4324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009486_2_0_1"/>
    <dbReference type="OMA" id="CCEFTGY"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="108"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="114"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="711" mass="78734" checksum="58A0BA9BD9E653FA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2T964</accession>
    <name>M2T964_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_170257</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698840.1">
        <property type="nucleotide sequence ID" value="XM_007700650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T964"/>
    <dbReference type="STRING" id="665912.M2T964"/>
    <dbReference type="GeneID" id="19132682"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_170257"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_1_1"/>
    <dbReference type="OMA" id="RVHHIGE"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="33"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="394"/>
            <end position="516"/>
        </location>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="53" mass="5967" checksum="C2794E7984F25D69" modified="2013-05-01" version="1" fragment="single">VRSEQNASIHFSSFCGMPRAFILCSSLSLHTPLYAPLTSKLIRLTVRRPRHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAX8</accession>
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        <recommendedName>
            <fullName evidence="7">GED domain-containing protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="5 6">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD66037.1"/>
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    <dbReference type="eggNOG" id="KOG0446">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_7_1_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Dynamin_GTPase"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
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    <dbReference type="Pfam" id="PF01031">
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    </dbReference>
    <dbReference type="Pfam" id="PF00350">
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="26"/>
            <end position="314"/>
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    <feature type="domain" description="GED" evidence="3">
        <location>
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            <end position="687"/>
        </location>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD66037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="77912" checksum="A25F96DD74180EB2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBY7</accession>
    <name>M2TBY7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR1/FUN34/YaaH-class plasma membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_112706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697867.1">
        <property type="nucleotide sequence ID" value="XM_007699677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TBY7"/>
    <dbReference type="GeneID" id="19130189"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_112706"/>
    <dbReference type="eggNOG" id="ENOG502SKF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_4_1_1"/>
    <dbReference type="OMA" id="GNFFPMM"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31026" checksum="DADCD06C5B717600" modified="2013-05-01" version="1">MATVTSPAQPTHSHTSVASDHIDKEPRLTHAQTNITISPELFEKLYLAPKVPHANERVTQYANAVPLGFLGFVISTFSFAMILMGWGGASGLQSIAGIFFFTGPLLLTLSCIFLWIQAQFFPMMVTGLFSVFWLSFGLLQLPSAGIAASFSATGNAAEGAASKELNAGLALFCIVWGFAMATFGIFTIRMNLVFVGIFWLAATATWLLSAAYWEVSKANFGKAMKLQKAGGALNFVVAILGWYMLIVIMMAEMRWTVNLPVGDLTHYWQKTDIEIAAMENEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2TC13</accession>
    <name>M2TC13_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_169328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697880.1">
        <property type="nucleotide sequence ID" value="XM_007699690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TC13"/>
    <dbReference type="STRING" id="665912.M2TC13"/>
    <dbReference type="GeneID" id="19132623"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_169328"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1390110_0_0_1"/>
    <dbReference type="OrthoDB" id="3677895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21474" checksum="15D0AFC8E2EF6F5E" modified="2013-05-01" version="1">MSQHAFANRLAGNNFQDEFAAFRRGQGLPAMTIDIGYLLSVGFIAGQDVYADHVKAMGLKVMQTSDLHGLLAAAIEGLSKHPGQVMCGLPFNEHGDTWYWIYDARFGALRNLATGTSANKGQVVSLREELVRCGTISEEAVQIITKAMVQRLASLMMISEEDMAVECSVFDVMQNIPMTQLACNLAEKSKLLVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCE4</accession>
    <name>M2TCE4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_168142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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        <location>
            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="57"/>
            <end position="79"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2TE40</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="EMD67012.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="154" mass="17590" checksum="49AE8D53CDEB8B03" modified="2013-05-01" version="1">MPPSASAFHFVVITQRFIAAIVILHQVTQRLGVLIPFSSIDPPDVSTLFWRPCCCATWLSCARFSHVVVFHPALRCFIIRLLYIALRVLSPLRDRCSAWSVYPLLLVLKYKHSNSRPPSFPSMCHSCHSSFELYRLGAEPWSLITRTRSSDFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEJ6</accession>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
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        <property type="protein sequence ID" value="EMD67167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="M2TEJ6"/>
    <dbReference type="STRING" id="665912.M2TEJ6"/>
    <dbReference type="GeneID" id="19135889"/>
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    <dbReference type="eggNOG" id="KOG2565">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_5_0_1"/>
    <dbReference type="OMA" id="TTYSMHV"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF71">
        <property type="entry name" value="EPOXIDE HYDROLASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="356"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="419" mass="47033" checksum="0513FFB1B7D547FF" modified="2013-05-01" version="1">MGSVAHGDEAITTYSMHVSSKYLELTRKKLELTRLPRELELPEERMWEHGTPKRVLEPLLDFWLETYDWRAAESRFNSLLPQFRTTIRTTSPTGTQSLRVHFVHKRSTRPGAIPLLLAHTWPSSFIEVQRIINALTEPQYVPDMGGAVPQAFHVVAPSIPGFGFSDASMQEGFGLEGTAEVFWELMGRLGYSEFVAHGTGWGFSICRVLAIRYPKACLAVHTVNPAFKAPTYRQSPLQYVKWRIAELTQAKVPLLSFGYVGSDVELRSGQRREDLGMQNEIGNSQPLGPALHRLCSLRPQTLAFSLCDSPVGLLAALLDVIHTRDVAPRPFSGRPRSPFLSPVELEMQQSDEEQVEVGQVPSGLMPQSPEYTTREDESDGKRCTWSPTEVLNFTMLQWLPGPEAVSEHHPIRPPISYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <name evidence="2" type="ORF">COCSADRAFT_352798</name>
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    <organism evidence="2 3">
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_352798"/>
    <dbReference type="HOGENOM" id="CLU_1618868_0_0_1"/>
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    </dbReference>
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        <location>
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            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="164" mass="17356" checksum="CFC911D05A814748" modified="2013-05-01" version="1">MDYGPLAKSLGRWALTDSCCQPTASEVKGDALLTSYLWTADGPPKTLPSAGLAHAIKDQESQSHLSRLSDDTSNHASTVTPLPFPPGRPGLQEAQVCFQPTPVSTPTYETLFSDTLPLSPLVFLLTCSHAAMQPCSHADKHGVALVQASAIAMAHAQPSEGLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_34587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGE8"/>
    <dbReference type="STRING" id="665912.M2TGE8"/>
    <dbReference type="GeneID" id="19137738"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34587"/>
    <dbReference type="eggNOG" id="ENOG502S8KA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175230_0_0_1"/>
    <dbReference type="OMA" id="TFIFIWG"/>
    <dbReference type="OrthoDB" id="3928876at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="231" mass="24800" checksum="EBEEDFE90E5E602B" modified="2013-05-01" version="1">MPSIAQKAGDIVDHVGHRVHHAAKSVEAQIGATTNQLLPPRRREQMIEQSRDYANRNPKIAAFLTTQAAFTGIPLVLFLAFAAVTLLVSLTTCLFLGLLVSLSITFFVVGLALIFVVPTVFIASFSAIFIFIWGLAGFIILRKFNERGASAKPSTRFGDAVKNGNAAGTGETYADDPTSSGDGGPVSRVHGTVEWDRKWADGVKHDSVVLETDNAYQVLKAETPVPSVSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2TH99</accession>
    <name>M2TH99_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_274274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TH99"/>
    <dbReference type="GeneID" id="19135676"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_274274"/>
    <dbReference type="eggNOG" id="ENOG502QVG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053011_0_0_1"/>
    <dbReference type="OMA" id="RPRFMAQ"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="336" mass="37732" checksum="8FFFE8257320663B" modified="2013-05-01" version="1">MADVEVQYKLSQDQIDFFMENGWLKLSNCFTREQADKLQETLWTRLGMDPNDMSTWHTERTNMPFFHEFPVSTFAPKAWAGICSLLGGSARVDSNASTWKDGFIVNLGTPSGHNSVVRPQDLPQWHVDGDFFVHYLDSPEQALLVIPLWTDIVPGGGGTYICPAAIPHVAKHLYENPEGVSPRMTPRAQNPEFVEEKGLEWFNNLAASMPDDAFVEATGVVGDVYLLHPLMLHAASNNQLRNVRVITNPPVSVKEPFVFDRPDGNYSVVERKTMKALGKERLEGFKITGPRQIVVPERVRIQEEMKKKEEERLRKLKESAGLDGGKEEAKQVATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2THR6</accession>
    <name>M2THR6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_108559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695913.1">
        <property type="nucleotide sequence ID" value="XM_007697723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THR6"/>
    <dbReference type="GeneID" id="19130061"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_108559"/>
    <dbReference type="eggNOG" id="ENOG502SK3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009941_0_0_1"/>
    <dbReference type="OMA" id="IVETHAM"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="143"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="686" mass="78156" checksum="B88FC90F7C31F780" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI35</accession>
    <name>M2TI35_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_109931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696374.1">
        <property type="nucleotide sequence ID" value="XM_007698184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TI35"/>
    <dbReference type="STRING" id="665912.M2TI35"/>
    <dbReference type="GeneID" id="19130109"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_109931"/>
    <dbReference type="eggNOG" id="KOG4034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085757_3_0_1"/>
    <dbReference type="OMA" id="KERHYPT"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="217" mass="23996" checksum="3663287033E77B3A" modified="2013-05-01" version="1">MPRIQYLIPLLRPLAAPRVIASRQRLRFSTASTWRAEQPPPNAKPITNPSLPPNASSQHPSTPQQAQRAADLAAAESLTEGDSAQPPEPKPVLPSKHPRADIKPKDAATAPSLQKPKSPKKQKTPLVQKISLPPPKYHVSRSINKNLPIYTDYKRGGNLHLTTIRKITGDLSALRDELRVFLNKKNEDVKINSLTSHVIVKGHHTSQIAEFLQARGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK54</accession>
    <name>M2TK54_COCSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_206051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694515.1">
        <property type="nucleotide sequence ID" value="XM_007696325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TK54"/>
    <dbReference type="STRING" id="665912.M2TK54"/>
    <dbReference type="GeneID" id="19134319"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_206051"/>
    <dbReference type="eggNOG" id="KOG1408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005113_0_0_1"/>
    <dbReference type="OMA" id="ASYYTWA"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="832"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1072" mass="116274" checksum="8A175C3332ADBB33" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKM1</accession>
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        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_48329</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694398.1">
        <property type="nucleotide sequence ID" value="XM_007696208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKM1"/>
    <dbReference type="STRING" id="665912.M2TKM1"/>
    <dbReference type="GeneID" id="19140241"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_48329"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_14_1"/>
    <dbReference type="OMA" id="WAYINIF"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="744" mass="84690" checksum="270C6D7D227CBD25" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKU6</accession>
    <name>M2TKU6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_78822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694672.1">
        <property type="nucleotide sequence ID" value="XM_007696482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKU6"/>
    <dbReference type="STRING" id="665912.M2TKU6"/>
    <dbReference type="GeneID" id="19140685"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_78822"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_0_1"/>
    <dbReference type="OMA" id="FLERYMQ"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="142"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD69307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40570" checksum="5C5A448C060B078A" modified="2013-05-01" version="1">MAPAIRRLHVAVSGLGRMGARHANHFLHRTPKAELVAVFTPAENELAWAKENLELWGVKIYTDYDEMLKHEGLEAVCVATVTTVHAEQTIKAIEAGKHVLCEKPLSTKLDECRKVLETAKRYPHIKVMCGFSRRFDSSYLDAYNLALSGSIGRPTILRSQTCDKYDPSGFFVVYAEFSGGIFVDCNIHDIDLALWYFSAESKGKLLPRVKSVMAVGVTALEPDLAKFGDVDNGVGVVEFHSGQIAYFYSTRMNAPGQHDTTEIIGTKGKLAVNSNPATGLLENHTDTGIVREIPQNYYERFEQAFVEEARQFTDVVLDNKEVPVNLESSMEAVKIGVSLQDSLRTGKKILFDQQGNRVDDVRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLM2</accession>
    <name>M2TLM2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">COPI associated</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_77609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695194.1">
        <property type="nucleotide sequence ID" value="XM_007697004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLM2"/>
    <dbReference type="STRING" id="665912.M2TLM2"/>
    <dbReference type="GeneID" id="19140622"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_77609"/>
    <dbReference type="eggNOG" id="ENOG502S5A7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120579_0_0_1"/>
    <dbReference type="OMA" id="MDYSDAF"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD70051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14513" checksum="B2DA30169129C245" modified="2013-05-01" version="1">MDFSDIFRMVNFAVAVFVVLGGIAKLFPFNDFSHIILGVYLIIFGLGTALLEFQIPQQVARYASFMFSFLGRGIFYIFIGSVVVGDGWYRIIPGTIVGFIGVAYAALEFVPSIEPPANMRDADAGAGWGAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2QTX0</accession>
    <name>M2QTX0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_41701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705558.1">
        <property type="nucleotide sequence ID" value="XM_007707368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QTX0"/>
    <dbReference type="STRING" id="665912.M2QTX0"/>
    <dbReference type="GeneID" id="19140046"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41701"/>
    <dbReference type="eggNOG" id="KOG1462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016743_1_0_1"/>
    <dbReference type="OMA" id="NCVINPK"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="451"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD58584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="583" mass="63760" checksum="CFDDC50F39D198F3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZ55</accession>
    <name>M2QZ55_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_39969</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703577.1">
        <property type="nucleotide sequence ID" value="XM_007705387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZ55"/>
    <dbReference type="STRING" id="665912.M2QZ55"/>
    <dbReference type="GeneID" id="19139610"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39969"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_7_1_1"/>
    <dbReference type="OMA" id="AWPCSNL"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000009">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="46"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_94378"/>
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            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="86" mass="9196" checksum="ED8CB5979F422706" modified="2013-05-01" version="1" fragment="single">LLLDVVVGKGAAILELLSGEDQALLVRGNALLVLDLGLDIICPCLSARVPFQANISASIACDALRCGRLIDRGHAYRWCQRTPPRG</sequence>
</entry>
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    <accession>M2R5L0</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Rad26-like_helical_rpts"/>
        <property type="match status" value="1"/>
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            <begin position="325"/>
            <end position="371"/>
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        <location>
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            <end position="658"/>
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        <location>
            <begin position="665"/>
            <end position="728"/>
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    </feature>
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        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21048"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62464.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2R5V8</accession>
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            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
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    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
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    <dbReference type="AlphaFoldDB" id="M2R5V8"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="140"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD62554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="384" mass="42379" checksum="80E2C77F6A954BB1" modified="2013-05-01" version="1">MGITDSIGTTLSFISLLWIPATLLCCLPWVQKQMLYLHNITFFPGKWLTEPERAGFLKNQVVPFRIATKGKHELFAWLIAPLGVYAKNEIAFTEEKTGSKVEDTVAWKSLCKDPEARLLIYFHGNSATLAQERRTIEYRSFSAGASDKIFVLAFDYRGFGLSKGEPSESGLLDDAEAVIDWALNKCHVPPERIVLLGHSLGTAVVSGIAHRYAANSGIEFACLILCAAFTNAGNAFSSYSIGGVVPVLAPIRVFPAFQKWFAQRMVCTWRTDDRLAAMARTCSRFNLVLVHAESDSTMPWHETEALFHSTLRAAKDASPDDESFKEVEVVDLGKAGRREIWRSDSRSISKTIAKHGGHNTSMTWSPVALTILQVFGLTAGTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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    <name>M2R6Z2_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_358684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701114.1">
        <property type="nucleotide sequence ID" value="XM_007702924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R6Z2"/>
    <dbReference type="GeneID" id="19138575"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_358684"/>
    <dbReference type="HOGENOM" id="CLU_013929_8_5_1"/>
    <dbReference type="OrthoDB" id="3786747at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="55" mass="6222" checksum="C8454418B8F54FFD" modified="2013-05-01" version="1">MVSYRNNLKQSVRALAVAYDVPKSTLQRRLHGVQARLETASVNRKLSPIEEQSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2R7F2</accession>
    <name>M2R7F2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_335434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701221.1">
        <property type="nucleotide sequence ID" value="XM_007703031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R7F2"/>
    <dbReference type="GeneID" id="19137211"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_335434"/>
    <dbReference type="HOGENOM" id="CLU_1992440_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="125" mass="12626" checksum="13E2251049BF814A" modified="2013-05-01" version="1">MGSTNNSTTSTSTSTSTSTSTNSTGSTTSSSTSTSANKKKQCQQRRQKQQQQRRESHAVEPDVAGSMRRGGGLVGGGGMDQDAAVAVAVAVAVVKVVVVVVVVVVVAATTIAVSTRLATTVLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8T1</accession>
    <name>M2R8T1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_38208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701102.1">
        <property type="nucleotide sequence ID" value="XM_007702912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R8T1"/>
    <dbReference type="STRING" id="665912.M2R8T1"/>
    <dbReference type="GeneID" id="19139196"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38208"/>
    <dbReference type="eggNOG" id="KOG0675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018224_1_2_1"/>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023685" description="Calnexin" evidence="9">
        <location>
            <begin position="19"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD63354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="62539" checksum="F0243D4AFECB1D06" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2RA50</accession>
    <name>M2RA50_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_37513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSK1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD63754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700441.1">
        <property type="nucleotide sequence ID" value="XM_007702251.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2RA50"/>
    <dbReference type="GeneID" id="19139001"/>
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    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008307_2_2_1"/>
    <dbReference type="OMA" id="DKGMFKS"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="533"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="787" mass="84336" checksum="8C8EF86A096EC799" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RC02</accession>
    <name>M2RC02_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_36948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699830.1">
        <property type="nucleotide sequence ID" value="XM_007701640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RC02"/>
    <dbReference type="STRING" id="665912.M2RC02"/>
    <dbReference type="GeneID" id="19138858"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36948"/>
    <dbReference type="eggNOG" id="ENOG502S6Z4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029647_0_0_1"/>
    <dbReference type="OMA" id="ALWEKKF"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="34"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD64374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="459" mass="50256" checksum="BB125E28B287FC41" modified="2013-05-01" version="1">MPKRKRSSPAPAIESVSKSTPAKCAKICEKRLADAQKPLLQALRHASMLERQKHSRRKKYAVNKNETKTIHRLNSEYETLKALNLEQVGDQHLRKTLARVKSLKDAEPLQEYIAGIREGNKDVNTLNVTARLFKVKQVKNVVDRVVEDLKGVLGVAKGKEDAKEEVGGKKVQEKKAPKDEDTAKKEDVDMKDASDEGDDPYMAFSARIAEPSSGEDDSEASVTDDERPPSIVDSDSEHDPDTDLDADSESESEELGEVEEVDGANGELLSNEDSEDEDSRSDSDSDSAAIPTKNIKAKAIEEKPTSSAFIPALSHAAYFSGSESEASDLDVDVAPRKNRRGQRARQKIAELKYGQKAKHLEKAQRSATFDPKRGAVSGTDKRQRRGKPLGGGPQQSGGNAEPLGERSDKKDRKIGVGAKRDDKGELHPSWQAAKMAKESKKLKIDLSGAKPAGKKVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2RFN4</accession>
    <name>M2RFN4_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">Cellobiose dehydrogenase-like cytochrome domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_170044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698676.1">
        <property type="nucleotide sequence ID" value="XM_007700486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RFN4"/>
    <dbReference type="GeneID" id="19132668"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_170044"/>
    <dbReference type="eggNOG" id="ENOG502SQ2W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081649_1_0_1"/>
    <dbReference type="OMA" id="IYRIAQP"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023955" description="Cellobiose dehydrogenase-like cytochrome domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="2">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="221" mass="23582" checksum="3BAF0A7152A1FE76" modified="2013-05-01" version="1">MRFTGGLAAIVNLVQAWPASTDHTLSPRSTGYKDPETGFTFSETKAAATLTSNIIYRIAQPANISATQPYDIVLQVIAPSSLGWVGLAWGGSMVRNPLTVSYPNGQKATVSSRWATGHSTPQQYPSATYTPLSKGNKANSTHWQFTVKCTGCTSYNGSSGPVYVEPSGSRRLAFACSQGKVSNPGSTSASIPVHDVYNYITHDFSAGRNEGWAVLLERNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2RM47</accession>
    <name>M2RM47_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">COCSADRAFT_168875</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Endomembrane system</location>
            <topology evidence="19">Lipid-anchor</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697288.1">
        <property type="nucleotide sequence ID" value="XM_007699098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RM47"/>
    <dbReference type="STRING" id="665912.M2RM47"/>
    <dbReference type="GeneID" id="19132603"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_168875"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_3_1_1"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="22">
        <location>
            <begin position="331"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMD67694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="600" mass="68204" checksum="2833C0BA8D719137" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RMU8</accession>
    <name>M2RMU8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_32916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695402.1">
        <property type="nucleotide sequence ID" value="XM_007697212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RMU8"/>
    <dbReference type="STRING" id="665912.M2RMU8"/>
    <dbReference type="GeneID" id="19136955"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32916"/>
    <dbReference type="HOGENOM" id="CLU_3068538_0_0_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="5992" checksum="7AD1E5F3DE1EFF66" modified="2013-05-01" version="1">MFLIFALKDPSNNGVPKSDKWFPLCLFFLIFGLGSCFGWQTGYAINIARDFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQX0</accession>
    <name>M2RQX0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_204742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694442.1">
        <property type="nucleotide sequence ID" value="XM_007696252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQX0"/>
    <dbReference type="STRING" id="665912.M2RQX0"/>
    <dbReference type="GeneID" id="19134300"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_204742"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_5_3_1"/>
    <dbReference type="OMA" id="EDQWPEM"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000046">
        <property type="entry name" value="Nudix/MutT family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD68974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="161" mass="18481" checksum="7E1E881CA27CEC8A" modified="2013-05-01" version="1">MAATQQLSMQSRTGRLNQRYGSQGERLVAGVVPLSADKYYVLLIQSTKRNGWVLPKGGWETDEATAQDAAKREAWEEAGIICKINYDLGLIPEKRRPDQLTSQAPKASYHFFEATVEKQEAQWPEQHKRNRNWFSYSQARQALAERPELLDALDRCTMHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RR24</accession>
    <name>M2RR24_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_130325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694483.1">
        <property type="nucleotide sequence ID" value="XM_007696293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RR24"/>
    <dbReference type="STRING" id="665912.M2RR24"/>
    <dbReference type="GeneID" id="19130781"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_130325"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OMA" id="SKTRWIW"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32211" checksum="7FB1FA0E00C6DF64" modified="2013-05-01" version="1">MAGNTRPQYALITGCTPGGIGHYLALEFAQRGFHVLGTVRDPAKYPSPDPRITYLPLELTSNDSIASLHKRVTEITGGKLDILYNNAGRNYVVPALDYDEAELHELFQANLFSLMKMCSTFAPLLIEARGIIVQTGSLAGIMPYVWGAPYNAVKAALHAYSDTLRVELAPLGVRVITVVTGGVKSNIARQDRTLPPGSYMQPLAAEYQRRLKHSQELGMDTKQYARSCVKQVLAGDGLFSKTRWIWEGKMSWIVWFAWTYLPTAALDFYFTTTFNLNKLRGTAGPDKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT71</accession>
    <name>M2RT71_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_350802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705871.1">
        <property type="nucleotide sequence ID" value="XM_007707681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT71"/>
    <dbReference type="GeneID" id="19138047"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_350802"/>
    <dbReference type="eggNOG" id="ENOG502TDAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136344_0_0_1"/>
    <dbReference type="OMA" id="EWVRRTW"/>
    <dbReference type="OrthoDB" id="3786276at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="151" mass="16941" checksum="65123EE4B1A05378" modified="2013-05-01" version="1">MAVIRVLMRIEQLEGVQVGLSTSLEVMEDAEVRCFAVLSCPICRQRRFSLASVTVISATVTEWVRRTWLGGSIDNDVLLGDIHLDRADAEMLSRELMTLQLSHFVRVMTRLETTLSAASSVHTVGYQDIVRSKLQELHDCKDQIHKLSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT79</accession>
    <name>M2RT79_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">COCSADRAFT_166738</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694999.1">
        <property type="nucleotide sequence ID" value="XM_007696809.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2RT79"/>
    <dbReference type="GeneID" id="19132470"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_166738"/>
    <dbReference type="eggNOG" id="KOG0560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001975_1_0_1"/>
    <dbReference type="OMA" id="YGSYTQV"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000085">
        <property type="entry name" value="Sulfite reductase [NADPH] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
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            <end position="938"/>
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            <end position="267"/>
        </location>
    </feature>
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            <end position="267"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD69774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
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        </source>
    </evidence>
    <sequence length="1529" mass="168465" checksum="E4405F2F0B0FC71B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUD7</accession>
    <name>M2RUD7_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_165036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_165036"/>
    <dbReference type="eggNOG" id="ENOG502S997">
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    </dbReference>
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    <dbReference type="OrthoDB" id="2152896at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
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            <begin position="22"/>
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        </location>
    </feature>
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    </feature>
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            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="430" mass="45948" checksum="6339AC13DD0B9B79" modified="2013-05-01" version="1">MAGSLPKNRTHSQSISAANLHPAHRVTRRKSMSQTPVTNIAAIAAAAKGMSGAPLEGASSSGSSSGPRRSSKPASQFRGPSMATASSMASSVPAHGAQFGASSYGSAAKSEALTDGPTLATMLEQDKANAKSRNRRASEGSRLSKGDGKRSGSELRCEKCGKGYKHSSCLTKHLWEHTPEWQYTSKLLISKHQQVQLLEAASVLVAMNKESDGEHSDRSSPPASGSSDVREDLSSTETTPPPQLDDHAVGSYPHSHFGTRSMKRYSTNSSAYSQSYQSTVFSDNGNGNAHGHFRQWSNVSDRPTTSGTSVAGSYHDDANDHADLAAAVGLLSCSYGTPKTGPVALPADAPPVPPLPAKYFDLNARTLSGSTTVTAQQSSMRNSYRHISESKDVDMDDDHFADEEDYRYSNARSRSRIDEDDDEIFGRMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2RVT9</accession>
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        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_41050</name>
    </gene>
    <organism evidence="8 9">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD59173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007706650.1"/>
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    <dbReference type="AlphaFoldDB" id="M2RVT9"/>
    <dbReference type="STRING" id="665912.M2RVT9"/>
    <dbReference type="GeneID" id="19139898"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41050"/>
    <dbReference type="eggNOG" id="ENOG502QT50">
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    <dbReference type="HOGENOM" id="CLU_079101_0_0_1"/>
    <dbReference type="OMA" id="LWMDMVE"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="239" mass="26775" checksum="9A8BD13808353C77" modified="2013-05-01" version="1">MKVLTKEEEQAHYNATVKGGSIGGLIGTAVGAAAVVGASRRYHSFRALTVPFRAFLIASTGTFVAVIAADRASARYDIEHTPEKKRQIERDQQRESLLEANKTPFQRAKDWATENRYPLLFGFWVASMAGSWHMVNRNPYLSGSQKLVQARMYAQGGTLAALLGSFAIEGADAAKGKGRWETIKIIDPNDPEHKHIIEKKIHHERYAGEDQWREMVEAEEQRQKEREAAKANGQRAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RWE1</accession>
    <name>M2RWE1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_153094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705113.1">
        <property type="nucleotide sequence ID" value="XM_007706923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RWE1"/>
    <dbReference type="STRING" id="665912.M2RWE1"/>
    <dbReference type="GeneID" id="19131610"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_153094"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034301_0_0_1"/>
    <dbReference type="OMA" id="ELWTYPT"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="467" mass="51134" checksum="4738387F9F73D518" modified="2013-05-01" version="1">MAEALNTEDLVSHLQSVLLELNANPYPDVACPPDLPKRASVALILRIQPSYAHWPNSSDSPLPKRRRRSSAAKPADEFDFESSLSAFFNQEWVKHGDPELLFIKRATRIGDKWNGHVALPGGKRDPEDSDDQVTAAREALEEVGVDLSPDNAIAVGNLPQRIVTTSWGKVPLMVLCPYIYLLTSPFYPPQRLQPTEVASSHWVPIRALLSPALRTHEYADVSARLAKSELGIKRWFLQAMLSKMMFAAIQLVPANSTHCATIPDFIPIDEESQGILSHVRDALAGPASRSKDRKPPLLLWGLTLGVVSDFLEHIPPHNALELWTYPTFTSWDVRAILWAMSYRFRKQKAVEMSSAVSSVSDTSEGPTQDLPGIGSEAVGSLEEQEKPGEVGIAGLGVGRTWGQSGRSKIMARGAAVNSMLEGYYPIIRHAVTAALVVRIGVVGLAAFLTSKKLGPAPFEMVKSLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RX64</accession>
    <name>M2RX64_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_152048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704646.1">
        <property type="nucleotide sequence ID" value="XM_007706456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RX64"/>
    <dbReference type="GeneID" id="19131579"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_152048"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_1_1"/>
    <dbReference type="OMA" id="FWNCLAW"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF27">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="58112" checksum="D409D51F9C39955D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXZ0</accession>
    <name>M2RXZ0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_164106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007706020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXZ0"/>
    <dbReference type="GeneID" id="19132291"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164106"/>
    <dbReference type="HOGENOM" id="CLU_2454396_0_0_1"/>
    <dbReference type="OMA" id="CQNAETK"/>
    <dbReference type="OrthoDB" id="10361761at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025281" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9600" checksum="2D9C6DE084A09589" modified="2013-05-01" version="1">MRFIISIFALSAALASAMEVASAPATDASPAPVEQVCSDFLNRCTQDGDPCSTFCQNAETKELISIYEKFCLKVGEEWTCSGEQPNRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZ47</accession>
    <name>M2RZ47_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_124960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703696.1">
        <property type="nucleotide sequence ID" value="XM_007705506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZ47"/>
    <dbReference type="GeneID" id="19130612"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_124960"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OMA" id="GWGTSYV"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF66">
        <property type="entry name" value="MFS HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD60308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="531" mass="59860" checksum="E8D99785C3AC908D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZM9</accession>
    <name>M2RZM9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_150475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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                <person name="Wu D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701957.1">
        <property type="nucleotide sequence ID" value="XM_007703767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S681"/>
    <dbReference type="STRING" id="665912.M2S681"/>
    <dbReference type="GeneID" id="19134618"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_222726"/>
    <dbReference type="eggNOG" id="ENOG502QXN4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029718_0_2_1"/>
    <dbReference type="OMA" id="FRMERLI"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024708" description="cellulase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="73"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD62633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="370" mass="40345" checksum="DA02BCC8FE8D99D6" modified="2013-05-01" version="1">MLFKNLFVAVALVGTALACPHPKAAAHPKAAAQPQPADHAQAGSAAVAASSANTQATQSQSNGKLKWFGINESGPEFGEAHIPGLYNKDYIWVDTKQVDQFLAQGMNMFRINFLMERLTPNSLTADFDSNYLGNLTAAVKYITSKGAYAMVQPHNYGRFNGQVISDTAAFKTWWTNVAKQYKDNSLVVFDINNEFHDMSNDLVFSLNQAGIDGIRAAGATTQYITPEGNSWTGAWTWVSSGNAASLIKLKDPKNKLVFQMHQYLDSDGSGTNANCVSSTIFQERLVAATQWLKDNKLQGVIGEFGAGSNAQCLTAVQGGLDYMAKNSDVWLGAIWWAAGPWWGDYIYSMEPTTGAAWSYILPKIKSYFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6Q4</accession>
    <name>M2S6Q4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700970.1">
        <property type="nucleotide sequence ID" value="XM_007702780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S6Q4"/>
    <dbReference type="ESTHER" id="cocsn-m2s6q4">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="19139064"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37725"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_14_4_1"/>
    <dbReference type="OMA" id="WLYYFNE"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF11">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="10"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="544" mass="59115" checksum="A57F239CF45EB9E7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7Z2</accession>
    <name>M2S7Z2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_26733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700329.1">
        <property type="nucleotide sequence ID" value="XM_007702139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7Z2"/>
    <dbReference type="STRING" id="665912.M2S7Z2"/>
    <dbReference type="GeneID" id="19135552"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_26733"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331851_0_0_1"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025507" description="Epoxide hydrolase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD63373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22912" checksum="B167062F8D2E3E00" modified="2013-05-01" version="1">MCSLKRILPFISLSIATLQTTPLRDVSLNYQPRPYNVSIDLFVIESPRKKASIFRSTVNTSALAWFDSLLATDTKLITSINTNFSNFYITVPPPNRPYNDSRPDVIPILLLHGWPSTALKWVSTIPSLVSPDNNSEPAFHIIAPDIPDFGFSSVLNNFRVGLGYKRYAVYSTDLGTTIAMGLVVNPAESVMQYVTDFYITFPGPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2S863</accession>
    <name>M2S863_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700389.1">
        <property type="nucleotide sequence ID" value="XM_007702199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S863"/>
    <dbReference type="GeneID" id="19138949"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37312"/>
    <dbReference type="eggNOG" id="ENOG502QYB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_297922_0_0_1"/>
    <dbReference type="OMA" id="CETCQAS"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122070" checksum="9F98977D1189E78D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SA35</accession>
    <name>M2SA35_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_30851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD59400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704823.1">
        <property type="nucleotide sequence ID" value="XM_007706633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SA35"/>
    <dbReference type="STRING" id="665912.M2SA35"/>
    <dbReference type="GeneID" id="19136330"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_30851"/>
    <dbReference type="eggNOG" id="ENOG502RE6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_6_1"/>
    <dbReference type="OMA" id="CRKYAYD"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="339" mass="37740" checksum="BF194600E7FEF2E9" modified="2013-05-01" version="1">MSKLIVIIGITGNQGSSVAHTFLSSPTWRIRGLTRHPTSPTSQHLSSLGIEMIQADLHDPSSLSRAFDGANLIFSATDFWTPFFTPSNAARAAELGIPIGRLAYELEAEQGRNIVDAVAKVVDGLDEVGFVASTLCNARESSEAKYKELWHFDGKADVFPKYVKEKYPEVAKKTSYLHTGYFYTSWRYMPNRWFAKLPDGSVQMQSPTSPDTLIPHLHPRTDVGPFVQAMLKLPPGSTVMAASEWCTWPDWIKTWGEVTGVKTSYKQVSVEDFDKEIPGGAGKEIGEMFEFSSTWGYNANQKDTLMTWDLEKMGVHVPTMSLKEYCKKEDWVAAGILAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAT2</accession>
    <name>M2SAT2_COCSN</name>
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        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_40772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD59600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007706290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SAT2"/>
    <dbReference type="STRING" id="665912.M2SAT2"/>
    <dbReference type="GeneID" id="19139827"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40772"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="OMA" id="ISWGIVH"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="563"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="791" mass="86878" checksum="77923C6DDFE164DC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBM3</accession>
    <name>M2SBM3_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_40369</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704060.1">
        <property type="nucleotide sequence ID" value="XM_007705870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBM3"/>
    <dbReference type="STRING" id="665912.M2SBM3"/>
    <dbReference type="GeneID" id="19139715"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40369"/>
    <dbReference type="eggNOG" id="ENOG502QQTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007201_2_0_1"/>
    <dbReference type="OMA" id="IWAEAST"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="813" mass="91307" checksum="E45C33A804D56318" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDB1</accession>
    <name>M2SDB1_COCSN</name>
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        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_35361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD65293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG4835">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
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            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="308" mass="34382" checksum="06E3CDB94A51262F" modified="2013-05-01" version="1">MDPQIDLPDLVEDLEVDIDELTTALEPLLSKPLSTTASSLPLLDKAKLYCLAAYAIESLLFASLTASGVNATEHAIFKEIARLRQYNSKIKEIEDRGIKGSAEGRARLDVAAAGRFIKHGLLGNDKYDLERQERMAKERARAHLKAQQINKKFDNEGKEVQKGQNVTPKKRGAEEKEEEDEEDEQVLEGLEEEPAVKKARVQDGTEADIPQPRKRGRPSKKDRKAEEAQTRTTRKRNTRLANQDAEENQEEEGQAEEEGEDDDEVADQAPKTRSETFTALLDGSLSEKHKQKKAKGRGGKKNGKGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SEE9"/>
    <dbReference type="STRING" id="665912.M2SEE9"/>
    <dbReference type="GeneID" id="19131136"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_139805"/>
    <dbReference type="eggNOG" id="ENOG502SE79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050897_0_0_1"/>
    <dbReference type="OMA" id="NAYYTVG"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="434" mass="42174" checksum="338045385FEDD75B" modified="2013-05-01" version="1">MSALDQIKQQNAALQSSVGNISKVAGPTAKKSTTATPVKPATKAAPVKKASAVTTDTTSPAATPVKRVPRKLNAAGTPTSNVTKTTTTPAAAKKLDSTPAVKKTPVTAGKTSVSEVSKPARTRTPLGTIKPLPVRNKSAADTPVTKSASTVKKTTTSTPVKSTSTPVKATPVKAPTTAGKNTSTVKKTPIKVNPDGTYPTPLSIIQAYPPPGQQPPKRAPGAVGKTINTATGTLNKTVGTTTGTLNTITDSATAGVNRTVDGVTGVAGKGLDKLPAGVGKPVKHVTDGVGKTATGAVDNAYYTVGSATKGVQGTVSKTTGALGRGDVKGTVAGATSGVGNTVTGVGKGLGNTVGDGLAGLGSTVGGPVGGVVGNVGKGANNAVSGITGGLGDGVSKLGKGDVIGGVGSTLGGVGRGVGGLLGGITGYGEGREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEI3</accession>
    <name>M2SEI3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_139902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698752.1">
        <property type="nucleotide sequence ID" value="XM_007700562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SEI3"/>
    <dbReference type="GeneID" id="19131142"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_139902"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OMA" id="QAFSYTF"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD65673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="558" mass="59187" checksum="F2D9481D380B4729" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEJ3</accession>
    <name>M2SEJ3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_124057</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
            <location evidence="1 15">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 15"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703251.1">
        <property type="nucleotide sequence ID" value="XM_007705061.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SEJ3"/>
    <dbReference type="GeneID" id="19130581"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_124057"/>
    <dbReference type="eggNOG" id="KOG1057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000914_2_0_1"/>
    <dbReference type="OMA" id="AQIWACS"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    <sequence length="1555" mass="171126" checksum="EBD92A05C181CB05" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGM0</accession>
    <name>M2SGM0_COCSN</name>
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        <recommendedName>
            <fullName evidence="13">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">COCSADRAFT_34936</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
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        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
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        <location>
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    </feature>
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            <position position="23"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="79227" checksum="946547882D287B2A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIX9</accession>
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        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">COCSADRAFT_93832</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
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                <person name="Han J."/>
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                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
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        <location>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="326" mass="36009" checksum="CEB450D7B66E4F53" modified="2013-05-01" version="1">MSIELTEHDWDSHKAIIHSLYLTENRKLQGAGSVMQEMLCKYDFKATPSSSDTSGSQKETEVWDGHDRIPEKNLKKELARYGYDVAFPYGCQAPTPKTPEGLYICTPAALQDDTTLLYDLPWFQFLDTIESRISPYPDLAAVAISMVNKSISNPSQSKPQDLGTVGYMSLIPDTVISALSKCVTTGITPTLSNTVRRIHSHLRAIIPEEFERESNAGHKDTSGLIKMTGNVQHLSLAVFLLTNNMLNTEKVAVMTQLFQDTSNVQFLRSLLSVRNPTVEALAEKLLLAAIQSEHQFMAQTCLEAGADPNSQLLGRTALQCQRTASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKR6</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">COCSADRAFT_352768</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67763.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKR6"/>
    <dbReference type="GeneID" id="19138176"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352768"/>
    <dbReference type="HOGENOM" id="CLU_2108820_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="115" mass="12009" checksum="451FFC2AF4293E5C" modified="2013-05-01" version="1">MVPQFRFSGAKARMALLRVALPLLSMSLLSLLLLLRGGCCHSNSATAATVLCQDSTAAKNLELSPNHSNQLIQSRRTASSPLASSEPAVIAIAAPDYEHRNGRRSPAGGGVSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLB3</accession>
    <name>M2SLB3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_161589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701322.1">
        <property type="nucleotide sequence ID" value="XM_007703132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLB3"/>
    <dbReference type="STRING" id="665912.M2SLB3"/>
    <dbReference type="GeneID" id="19132110"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_161589"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD63060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="261" mass="29897" checksum="84CE066D563E6CFE" modified="2013-05-01" version="1">MPQNEYIERFTKQHGKRFDHDERQRKKEAREGHNASKKAQNLRGLRAKQYAEKRRKEKIQMKQKIRAHEERNVKSNEAPEPATEALPSYLLDRSNEKNAKALSSAIKQKRNEKAARFSVPLPKVKGISEEEMFSVVKTGKKTKKKSWKRMITKPTFVGPGFTRRPVKYERFIRPMGLRYKKANVTHPELNVTVQLPIISVKKNPQQPLYTQLGVLTKGTIIEVNVSELGLVTAGGKVVWGRYAQITNNPENDGCLNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMT8</accession>
    <name>M2SMT8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_279469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705912.1">
        <property type="nucleotide sequence ID" value="XM_007707722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMT8"/>
    <dbReference type="STRING" id="665912.M2SMT8"/>
    <dbReference type="GeneID" id="19135780"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_279469"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_6_2_1"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD58466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22100" checksum="7875E8EC58C3C81F" modified="2013-05-01" version="1">MPNDKIPVLFMYTSPLTQSPSGVDVSISRPIDPGTDIWRESLRETVAYTLNSTEAFYTHSKILVTVLNRPVVGIAAALISFSDFISCAPHAYLLTPFTSFGLIAEGGASVGFVRCMGASKATEALLMSRKILADDLVACGFVNKIFKDCGEGEDEKLSERVVAHVDDILGPHLVGSSLLKTKKFLVLSMKRQIDQSVVTELMGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN65</accession>
    <name>M2SN65_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho1 guanine nucleotide exchange factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_331334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Leng Y."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Ohm R.A."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694447.1">
        <property type="nucleotide sequence ID" value="XM_007696257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP55"/>
    <dbReference type="STRING" id="665912.M2SP55"/>
    <dbReference type="GeneID" id="19134302"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_204886"/>
    <dbReference type="eggNOG" id="KOG1272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022996_1_1_1"/>
    <dbReference type="OMA" id="EFLPYHW"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="377"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="554" mass="62931" checksum="CEA78840B807EBFC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPC1</accession>
    <name>M2SPC1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_171206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700015.1">
        <property type="nucleotide sequence ID" value="XM_007701825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPC1"/>
    <dbReference type="GeneID" id="19132731"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_171206"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OMA" id="SICHEYY"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="70"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD64140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="461" mass="49014" checksum="8557C8A07EC02556" modified="2013-05-01" version="1">MPSDEKPNQLLSSSSSSSNTVQDVLDPSAKEQPPGEGVTTPDESGAALEAAQPQQPNANAASPPPNGGTLAWLQVFGAFFLTFNSWGVTNTFGSYQAYYETTLLQSSSSSTIAWIGSVQAYLMLVTGTLAGPIYDAGYLRALLLVGSFMIVFGHMMLSLCHAYWQVLLAQAFCVGIGAGLIYVPSVAILSTYFTTRIGAAIGIAASGSSLGGVIYPIVLHKLLPKIGFGWATRVLGFMVLGTLVVPNLVMRVRVLPPQTRTLFDLKAFLIPAYTCITLGFLLGFAGLNVPLVFAQIFAITEKITNADLGFYLIAILNSTSLFGRILPNLLSDKIGPFNVMIPCILMSAILCILFMTVTAPAGIIVLMALYGFFSGTFVSLPSTVIIYISGSAKNKIGTRLGQAFFFCAIGILIGAPIGGQIQKHSGYNDLWIFGSCLLFACAALVLIAKFTWEGLSLKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPF0</accession>
    <name>M2SPF0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_41729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
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    <comment type="subcellular location">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="89"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD64510.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="533" mass="58980" checksum="A1D204358722535A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQL5</accession>
    <name>M2SQL5_COCSN</name>
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            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
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        <name evidence="6" type="ORF">COCSADRAFT_32238</name>
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    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
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            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
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        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="332" mass="35853" checksum="460FDB59515AB7D7" modified="2013-05-01" version="1">MASIPKTMKAVYIEKTGGTDVLQYNDVPVPEPKEGEVLVKNEFIGINYIDTYFRSGVYKPTHFPYILGREGAGTIAATGPNTPADLKVGARVAYMGQSAYAEYVAAPAKTTVPLPDSIPTKTAAASLLQALTAVTLIREAYAVQKGDWILVTAAAGGVGLWLCQLLKAIGARVIATASTEEKRNLAKENGADVLLEYYEEDRDIFVKKVLEITGGEGVHAVFDSVGKATFDSSLAVVRRKGTMCSFGNASGPVEGFSLGRLGAKNIKLVRPTLFNYLATREEVLEASNELWKFIEKDGLNVKIHDIYSLSDIVRATQDIESRKTTGKLVLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR27</accession>
    <name>M2SR27_COCSN</name>
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            <fullName evidence="9">Serine carboxypeptidase S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_76240</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    </dbReference>
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        <property type="project" value="GOC"/>
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        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DUF7077"/>
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        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="33"/>
            <end position="234"/>
        </location>
    </feature>
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        <location>
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            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="1011"/>
            <end position="1132"/>
        </location>
    </feature>
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        <location>
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            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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    </feature>
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        <location>
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    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12584"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23274"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD59427.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695113.1">
        <property type="nucleotide sequence ID" value="XM_007696923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRR5"/>
    <dbReference type="GeneID" id="19134482"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_215340"/>
    <dbReference type="eggNOG" id="ENOG502S5DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084254_0_0_1"/>
    <dbReference type="OMA" id="GHWLDDD"/>
    <dbReference type="OrthoDB" id="4510061at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="179" mass="20213" checksum="6FDEC075D6CEA337" modified="2013-05-01" version="1">MSDGLNDARAMRVAEIMTDFRNLQHYLVQLRATPTAEEYYLDGYSLLRQCTSEAQAILQTPFASSTPSGTGDLEHEKRQLRAIIIDAAVRRFQCQRAYLRANAGLRWMNSRQSILRGEKPNASHMAALQQADATLRNELMAMTDAYIYDTLLAADAAQKKFLIDDPSLAQIQQIIMSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS44</accession>
    <name>M2SS44_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_193766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704641.1">
        <property type="nucleotide sequence ID" value="XM_007706451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS44"/>
    <dbReference type="GeneID" id="19133865"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193766"/>
    <dbReference type="HOGENOM" id="CLU_1128973_0_0_1"/>
    <dbReference type="OrthoDB" id="10328290at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="246" mass="27115" checksum="519B031175B0854D" modified="2013-05-01" version="1">MADVMQLGRQASRVERGAHVECLSGVLRVDHWLWLATEPYKVLQRTDWTRICQSGPYAFMALRPECQPVVFVSPSCTQPSFPCLIRLVASYQRHRMALAARIDRRAAETLIGLSIPMDGSWARMGGEAALERILVSFTACSVRVTACASFMLAPKPDVLVPGAGAQASWANGISSLPEIICKNIYVRAHKLKYMSKLEPTPGIPVEHGPDRRHKRVDLDVNPAVAVLPLLSPVLVSPLLTLRLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS74</accession>
    <name>M2SS74_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_318167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699607.1">
        <property type="nucleotide sequence ID" value="XM_007701417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS74"/>
    <dbReference type="GeneID" id="19136533"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_318167"/>
    <dbReference type="eggNOG" id="ENOG502TGB0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104690_0_0_1"/>
    <dbReference type="OMA" id="PWIAPPQ"/>
    <dbReference type="OrthoDB" id="3942886at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="231" mass="25961" checksum="F4E503F137A88665" modified="2013-05-01" version="1">MPPLPISTGVGCLDGWRTAVESQTLFSTVLLVSLFAITLRSIARILGRRRKSVLLFDKKMEDSGVGQEKLVVKKRKDSSQCGEMDVSARKQVHPDADSKENTNPEAQRHDTAHQSSMEQNQNEYLESLKQETLEPSRSPIYPWIAPPQSLPGPYDAPYFPVPLPTIAVAEITEECMKTEAPTDKRPEELETILYSRRIPTNISPENDTIREGVVTVSTRGWRRSQWTINTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSP0</accession>
    <name>M2SSP0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_40508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704103.1">
        <property type="nucleotide sequence ID" value="XM_007705913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSP0"/>
    <dbReference type="STRING" id="665912.M2SSP0"/>
    <dbReference type="GeneID" id="19139758"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40508"/>
    <dbReference type="eggNOG" id="KOG0439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032848_1_1_1"/>
    <dbReference type="OMA" id="GFKRPFN"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160219">
        <property type="term" value="C:cortical endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160214">
        <property type="term" value="F:endoplasmic reticulum-plasma membrane adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatidylinositol binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maintenance of ER location"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:reticulophagy"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="PapD-like_sf"/>
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        <property type="entry name" value="VAP"/>
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        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MSP"/>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="2"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="251"/>
            <end position="266"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="295" mass="31398" checksum="88AD8F7BB8D98C1C" modified="2013-05-01" version="1">MSVELDPVELGFKRPFQHEVSQTLRLKNPHSDPVAFKVKTTAPKQYCVRPNSGRIEPGKEVEVQILLQAMKEDPPPDAKCRDKFLVQSVLITADKEFANVGSLWSHIEQTSKSSIQEKKIRVLFLAPDEGGLSVTPAKTNSASHDSLVPSPSPSQEAFTPQRGGVSDASGPVSVPQDRPAGSKNLGEVRNETYNPATGGSAQGALNSAAASVSNAIPSSGDLEAQLAEAKAQIARLTQQVSEATGLRQRKTGSAQDSKSQVSTATEVRQAPAGGVPVQITALLCLISFLLAYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSV3</accession>
    <name>M2SSV3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_164280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007706162.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19132302"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164280"/>
    <dbReference type="eggNOG" id="ENOG502QT45">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006746_1_0_1"/>
    <dbReference type="OMA" id="SQFFYVA"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="5">
        <location>
            <begin position="34"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="812"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="812"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="903" mass="99622" checksum="CF1AE646A3384B4D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2STF8</accession>
    <name>M2STF8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_49807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704157.1">
        <property type="nucleotide sequence ID" value="XM_007705967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STF8"/>
    <dbReference type="GeneID" id="19140265"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_49807"/>
    <dbReference type="eggNOG" id="ENOG502T644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2764687_0_0_1"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="8077" checksum="42E8D3856936661A" modified="2013-05-01" version="1" fragment="single">DTRMRVLYTIGAIMTIGSTRSLPRVCAVFESQPAQFLGRISFSLYLCHITVFRVLRERFFNWTSQVLSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2STM1</accession>
    <name>M2STM1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_87451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698725.1">
        <property type="nucleotide sequence ID" value="XM_007700535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STM1"/>
    <dbReference type="STRING" id="665912.M2STM1"/>
    <dbReference type="GeneID" id="19141185"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_87451"/>
    <dbReference type="eggNOG" id="KOG1493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115512_0_1_1"/>
    <dbReference type="OMA" id="QWRWDTG"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD65635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="106" mass="12191" checksum="049483D6EF9B6F85" modified="2013-05-01" version="1">MKVTIREWNAVAAWHWDMPDDDVCGICRNPYDSTCSKCKFPGDECPLLLGECNHSFHMHCIFDWLKQESSLEKCPMCRQPFKSKSQDAPTATETPRQIQEPDTSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2STM8</accession>
    <name>M2STM8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TatD related DNase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_164251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704330.1">
        <property type="nucleotide sequence ID" value="XM_007706140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STM8"/>
    <dbReference type="GeneID" id="19132299"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164251"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_1_0_1"/>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000072">
        <property type="entry name" value="Hydrolase, TatD family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34598" checksum="938B56D0557B791D" modified="2013-05-01" version="1">MAASTQLKYIDIGINFTDPIFRGEYHGTQRHENDFEDVLQRAVDAGCKKFMVTGSDLEESKHAIEIAKAHPGLCYATVGVHPCSAKHFDKHPGGASELLFALKTLAIEAKEAGHVVAFGEIGLDYDRLFLTAKEPQLKYFEAQLEIAVEVQLPLFLHSRAASEDFERLLTAKLDQLPKRGLVHSFTGTAEEMQRLVDLGFDIGINGCSMKTDENIAVVKLIPLERLQIETDGPWCEMRPSHASAKFLKDAPPLPKAVKKEKWAKGMMVKGRNEPATIPHVAYAIAKIKEISVEEVCNAAWKNSVNMFGLGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUX5</accession>
    <name>M2SUX5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_150688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703909.1">
        <property type="nucleotide sequence ID" value="XM_007705719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUX5"/>
    <dbReference type="GeneID" id="19131536"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_150688"/>
    <dbReference type="eggNOG" id="ENOG502RYWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030268_0_0_1"/>
    <dbReference type="OMA" id="MDRASWY"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF11">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="475" mass="51893" checksum="EDE1BE4B1C0358CE" modified="2013-05-01" version="1">MAPAASSPSVSHFNEPFISALDAAAPSNASDDPSYYARYPRSLITTSNIDTFMTGTGSSIYESFAPLLESADHELILVTCFWARSASLDILNSVLRKLSTKAVIRGTQKIRVRLCFSSSSIFQKLFHSQGVTGQTYPPSTWVQKLGLPDPSELHGLNLEIKSIFLLPFSVMHPKFIIVDRKTAILPSCNISWEEWFEGAITLTGPIVTQFLKFYRSFWERKTDDLSTRPPSSSSDTPLPQPKQTSSLKSHVTLSAPEAPTVFLPSPHHRNPTFSPLTSSSLLQAPPTPLNLFVLTLFSKAERKITIQTPNLTSPPVLSALLRALARGVDVRILTSKRLMILEQLVTAGTTTTRCVRRLIRRYRALSSERQGLIDEESAIAAGQPGRLVVSYWTPLGGLKARGEEGGEAQQSHFKMVSVDEEVVVLGSGNLDRASWFTSQELGVAFFGKEVVSGILGAVEAGGRGRGKVVFDSGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVJ0</accession>
    <name>M2SVJ0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_174372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703386.1">
        <property type="nucleotide sequence ID" value="XM_007705196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVJ0"/>
    <dbReference type="GeneID" id="19132908"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_174372"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_1_0_1"/>
    <dbReference type="OMA" id="ERAINQD"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD61051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37069" checksum="2F02404DCC7F2988" modified="2013-05-01" version="1">MYALQVLHGVTVLISSDSITEDMNTEVEAVLMDMLGNVQDWKTIDLKTLIHRLAARVSCRVFLGPELSDNAEWIDIDVTYTENSMRVIYQLRSLHPIFRPIAQWWMPALRVCRLQVAKSREIINPLVQKRLQKKANGEATEKTADIISWIDDKARAKKTKIDFAELQLFLSFAAVHTTTEMISGLMCDLVENEHWISQIREETLLASMKLLGSAMKESQRLNKLTGLGTQRVVLSNVTFSNGTIIPRGYKLAVEHRFSDPTLYPKSEHFEAGRFLKLRDTDQSRWQFVTGSPEHLGFGYRKHTCPGRFFASNEINIIIVYLLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVS0</accession>
    <name>M2SVS0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_149266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703301.1">
        <property type="nucleotide sequence ID" value="XM_007705111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVS0"/>
    <dbReference type="STRING" id="665912.M2SVS0"/>
    <dbReference type="GeneID" id="19131485"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_149266"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074741_3_0_1"/>
    <dbReference type="OMA" id="PFQANYG"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="114"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD60937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="294" mass="31112" checksum="58D7D688D212E6CA" modified="2013-05-01" version="1">MAQYGYGQNPQYGAGNAQNLQFYSSSFSNQPVSGHSTPFQANYGAPASQAYPSQYGAGFSAPGVSGQMGMGTSGLRTGWLAAFGTEGYEGEPPLLEELGVNFKHIQMKTLAVLNPFGRIDQHIMDDSDVAGPILFFLIFGTSLLLSGKLHFGYIYGLAFVGTILLHQILSLMSPPVNTVEATPGDHGHPHGSHLGSSLTFPRSASVLGYCLLPLVLVAIFGIIVPLDGLFGYLLTSLAITWCSYSSSSMFTAVGRMTSMRGLVAYPMVLFYGSFGIMAIFSSRGTGQLAKAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVU6</accession>
    <name>M2SVU6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_239417</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703434.1">
        <property type="nucleotide sequence ID" value="XM_007705244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVU6"/>
    <dbReference type="STRING" id="665912.M2SVU6"/>
    <dbReference type="GeneID" id="19134963"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_239417"/>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_2_0_1"/>
    <dbReference type="OMA" id="MKCCHEM"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="98"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="594"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD61116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="675" mass="74140" checksum="7D58024C27716CB0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXJ3</accession>
    <name>M2SXJ3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_39344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702630.1">
        <property type="nucleotide sequence ID" value="XM_007704440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXJ3"/>
    <dbReference type="STRING" id="665912.M2SXJ3"/>
    <dbReference type="GeneID" id="19139478"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39344"/>
    <dbReference type="eggNOG" id="ENOG502S3XI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039527_0_0_1"/>
    <dbReference type="OMA" id="SGEKWQN"/>
    <dbReference type="OrthoDB" id="5407351at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="498" mass="55186" checksum="2072B20016543620" modified="2013-05-01" version="1">MADALCGPSNALQNFQKHTTVDRTLQQDRLVGRQSPVQGFRSAPGPNVGALDSEFDAFQTGRPGPPQDFQQFAPRFAQPPPQFAQVPQAPDWAADFQRLNVSGPPPQAFQQQRPQAASVASAWHQDFLKQQTPVAQAPALQQNTFGGMSGYGMGGFGGQAYMQTPSFQNAQMSDVAQGKQRAQNDVPAFDEAAFEQAFAQAQQDMMEVVEAEQAHAQPAQEALDLDRPGEMDPLLQRIRETRPAVYSAIQVWSETGLGRTSEAVAYLENMSQMERNGSLIQDANEGRWIVDSLQSIVNRDAPQEVKTRAEGLIKAINERLMSQYPLGTRVPMSEEQIWKDLEAAGYMRTPEPLQRMPQPPEEEQKQQEQPRPNQDDEMAATAGRLLERVADNTSEKFQNSQFLGLMRRLRDREVRVQEDKIVEVEGAAAAQQQTSTTSTTPPSTIPTAQQTNPQQTHQQPPSSTQIPHIDPTILSHAALDFEQPIYSDIGHGHEQQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXW7</accession>
    <name>M2SXW7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_285430</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696892.1">
        <property type="nucleotide sequence ID" value="XM_007698702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXW7"/>
    <dbReference type="STRING" id="665912.M2SXW7"/>
    <dbReference type="GeneID" id="19135888"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_285430"/>
    <dbReference type="eggNOG" id="KOG1123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_0_0_1"/>
    <dbReference type="OMA" id="RCQEIDY"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DEXHc_XPB"/>
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    </dbReference>
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        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="329"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="546"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD67165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="804" mass="90715" checksum="9C274A8F9B9EC7D5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXX1</accession>
    <name>M2SXX1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_95572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702200.1">
        <property type="nucleotide sequence ID" value="XM_007704010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXX1"/>
    <dbReference type="STRING" id="665912.M2SXX1"/>
    <dbReference type="GeneID" id="19141626"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95572"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036731_1_0_1"/>
    <dbReference type="OMA" id="LYENLDW"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="357" mass="38617" checksum="82F8CC875C426276" modified="2013-05-01" version="1">MRYLRFLKPPRILRDKTTNAASVACLATLVSDLGDSFLPHHVHLAAELLLCTHDVEHVLVWTSVRWASGMRSLPITIPLPKSHALPSSLLRLRVGIGPGNSPDEYSALAGQDARGVVSAWSAPFTLDDDAPKLVQRRFSLSPHSDIAIWEETGESIAKHLWDAGITLACHIPDLADTKSTLAKALLHSTEASPLTILELGTGCGIVGIALAQTISNANILLTDLPEAREIVQRNIDQASRAPGTKLSFLELNWDAQLPDESQSTLTSVNLVVAADCTYNPDSSPALVSTLSRLAMSNPAIVIAIAMKMRHSSEEVFFHLMAHAGFIETAKLEFLLPGDVEAGEEIIYLHVYSTSMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYA2</accession>
    <name>M2SYA2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_95107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702290.1">
        <property type="nucleotide sequence ID" value="XM_007704100.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SYA2"/>
    <dbReference type="GeneID" id="19141597"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95107"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001592_2_0_1"/>
    <dbReference type="OMA" id="KAVFFCA"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16568">
        <property type="entry name" value="RING-HC_ScPSH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000059">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="344"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1145"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1205"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1407"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1407"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD61926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1512" mass="170344" checksum="C5F250916C33EDAC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYE9</accession>
    <name>M2SYE9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_95404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702227.1">
        <property type="nucleotide sequence ID" value="XM_007704037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYE9"/>
    <dbReference type="STRING" id="665912.M2SYE9"/>
    <dbReference type="GeneID" id="19141616"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95404"/>
    <dbReference type="eggNOG" id="KOG3928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046315_1_0_1"/>
    <dbReference type="OMA" id="GLAHWMT"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD61832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="479" mass="52375" checksum="8A72A23428DB87FA" modified="2013-05-01" version="1">MPPSTCLRSFSQLSLDATPAVSRLLRPHVACFSTSSMQYAAVAKKKGMAAAPKKGVKSLNTKKGKKAPGAGDTGKRPAQGERKAQRKRIVLSNDNALEVSSLQDLAKDNVLSDKNEGKVMGLPQENVVDALRAVEAFKTSQGWSLFRRPAVLMRKEAIQLAKLFKDVEDSAAGQKKTVRRILCGERMSGKSTLLLQGLAMAFLRDWFVINLPEAQDLVNAHTEYAPLPDSEPLQYTQDTYTANLLQQMLKANSAFLQATKLSTKPNLPLPLATKATLKELVALGVANPEVSWPVFVALWNELSLPGRPPILLALDGLSHIMRHSEYMSAQVKPIHAHDLTLVRHFVDHLSGQKKFANGGVVLGATSQSNSPTSSGLDFCIQVAQARKVSADKVPQWNPYKSVDARVMEALKGLHDNSSDFNIIEVGGLSKEEARSIMEYYAESGMLRHRVDEGLVTEKWSLAGMGNIGELEKASVRMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYI8</accession>
    <name>M2SYI8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_226798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702343.1">
        <property type="nucleotide sequence ID" value="XM_007704153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYI8"/>
    <dbReference type="GeneID" id="19134689"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_226798"/>
    <dbReference type="HOGENOM" id="CLU_1927424_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025923" evidence="1">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="131" mass="14827" checksum="01F3A1D07A05460F" modified="2013-05-01" version="1">MLSYHIVSYRIVSSASLLLLLPPLSSPLKNPNPSMQSWYSTPSLCAAKTKRRNDASEMLWTDTTKKRQLAGRQDRILMPLNKGETNVQTKQSRDEEKESIIAKKKCLNHISSRLISIPSHPFIHERVSASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYZ8</accession>
    <name>M2SYZ8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CSI2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_95594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702352.1">
        <property type="nucleotide sequence ID" value="XM_007704162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYZ8"/>
    <dbReference type="STRING" id="665912.M2SYZ8"/>
    <dbReference type="GeneID" id="19141627"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95594"/>
    <dbReference type="eggNOG" id="ENOG502S625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037244_0_0_1"/>
    <dbReference type="OMA" id="ANAPYMQ"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025453" description="CSI2 protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="38713" checksum="07A3716352152241" modified="2013-05-01" version="1">MRPSAGIIGLLLIAVPTVLAQGNNAPNAPNAPDGTTTTQPTNDQTTQTTANTQTSQTATSATTEAASTTQTQTGSRSVFNLAGAPTLAGVGIPVPKIPDTSGAAFMQKSSLPDGTVFICVGAILAFFGAALMAWRGLVAWSLHRSVKRAALSQNMTDVKSMTAMPPNKRGMYNVVGANSTMSLDRLNAAPIGKSSRPFTGAPTSSSQRPVSSLFFSPTAGGATGIRDSVVNRSSAYLPAGYYASGTSAPASGSPQMNVGGQNFNNLSALSLSTPGNRFSARSGTSPPESPSLPPSRGGYSRAPPSREGLSVYKRSSVATLTTPGNTRSGVFGQDNNPSQLSLNVPGGTNVPGGRTPSGYLEDLFEHHGTNGNNGTERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZG1</accession>
    <name>M2SZG1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_183275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702461.1">
        <property type="nucleotide sequence ID" value="XM_007704271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZG1"/>
    <dbReference type="GeneID" id="19133404"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_183275"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_2_1"/>
    <dbReference type="OMA" id="DAYITYA"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="104"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD62162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="544" mass="59400" checksum="B38EC3C9EE6B43FE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZM0</accession>
    <name>M2SZM0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_220300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701780.1">
        <property type="nucleotide sequence ID" value="XM_007703590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZM0"/>
    <dbReference type="GeneID" id="19134570"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_220300"/>
    <dbReference type="eggNOG" id="KOG4539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043838_2_0_1"/>
    <dbReference type="OMA" id="PFFYLAY"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="38012" checksum="93BE27162252BD25" modified="2013-05-01" version="1">MRLFLLPISTRRSLIYCERLHEKAPKDRSLYDKITLKASETWVAWEKDQKAVWDWKRKVTFYGNQALTRIPYEEWGLKTIPALTAKRRQEILDGKAKYEVLFPGKYLPQERVPSLLEKLAKERQNMHRTKLIWSVVIMPFTAPFMLVPIIPNLPFFYVLYRAWSHWKALGGARHLEFLLKHNLPKHNPSWTLDELYTAGLMYPTRALSRAAPRPTPQQAQQVAAVVHQQTNNETEDVMVLQRWNGKLIAEQFNLPDMEVEIERAVSQVEKAIKSKEERMEEKIEQEMAAGSNGTRAKDALPKEILENIQNKAEDIAEDTKAGMNKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZS3</accession>
    <name>M2SZS3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_191566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701694.1">
        <property type="nucleotide sequence ID" value="XM_007703504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZS3"/>
    <dbReference type="STRING" id="665912.M2SZS3"/>
    <dbReference type="GeneID" id="19133773"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_191566"/>
    <dbReference type="eggNOG" id="KOG0879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="OMA" id="CVSIYGH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD62282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="222" mass="23320" checksum="ADEDE9B04263D9AA" modified="2013-05-01" version="1">MGCGGSKEKNASKPTEMARPVQLDTPGQHDINIPVAGEGATAKARRSPDNPIVYFDIAIGGQPVGRVQMELFLDVVPATTENFRQFCTGECKVGGYVGSTFHRVIPNFMIQGGDFMGGDGTGSASIFGSESFDDENFQLKHTHPGLLSMANSGPNSNGSQFFILTAATPHLDGKHVVFGEVLDGMDVIRKIESTRTGPGDKPLSPVTIAGAGQLAGAKPLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0C6</accession>
    <name>M2T0C6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_121193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701841.1">
        <property type="nucleotide sequence ID" value="XM_007703651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0C6"/>
    <dbReference type="STRING" id="665912.M2T0C6"/>
    <dbReference type="GeneID" id="19130478"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_121193"/>
    <dbReference type="eggNOG" id="ENOG502QRBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_2_1_1"/>
    <dbReference type="OMA" id="WAWLCGT"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="529" mass="57186" checksum="74C8D715EA78987E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2T117</accession>
    <name>M2T117_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">COCSADRAFT_119713</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701210.1">
        <property type="nucleotide sequence ID" value="XM_007703020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T117"/>
    <dbReference type="STRING" id="665912.M2T117"/>
    <dbReference type="GeneID" id="19130421"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_119713"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009279_1_0_1"/>
    <dbReference type="OMA" id="TWYAIGT"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="23"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="545"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMD62906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="751" mass="83867" checksum="494D5082C59FEB5D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2T134</accession>
    <name>M2T134_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_200555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701222.1">
        <property type="nucleotide sequence ID" value="XM_007703032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T134"/>
    <dbReference type="STRING" id="665912.M2T134"/>
    <dbReference type="GeneID" id="19134147"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_200555"/>
    <dbReference type="eggNOG" id="KOG4342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_0_1_1"/>
    <dbReference type="OMA" id="GQYWDAW"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="560"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD62921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1120" mass="127213" checksum="A98E2FCFCD02B56A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2C5</accession>
    <name>M2T2C5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_38043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701058.1">
        <property type="nucleotide sequence ID" value="XM_007702868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2C5"/>
    <dbReference type="STRING" id="665912.M2T2C5"/>
    <dbReference type="GeneID" id="19139152"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38043"/>
    <dbReference type="eggNOG" id="ENOG502S7S0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044030_1_0_1"/>
    <dbReference type="OMA" id="WEVAVWD"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52898" checksum="BD81F90C6FFDC336" modified="2013-05-01" version="1">MPRLVRRAPLAERIKAYTDPSDWLIWISEELNSSDWEDFASLYSLYIGFGANLLFVLAQANSGASAASDDDGVFNEVEGPGWLKSTLSLLVMVLGGISFVNAWLVWGKRRYYRLFEQKVDVAPRTPSAKRVRVDSSPAAASPMQFVRNLVQNNAADRAHPIEGRDVWEVAVWDPNPLCLKLFCLFSPLHVVLYYLNLPVGPLDPSPSVRVTTTILIGAVLSLQLWWLQSSFSQQIKDNALISRQVLHEYDSKFVHPSLQKPCRDVGVQTISKNRNQDSSVGVKGSSDDLASEIVTYTPKTVINRTFRTNPNASYASQYDPDNARSTSNTPSLRRRDSNPQYATTSTGTDADIFSPIRSSQPPNPFRQAPTISRNSIDTKVNDGGYLGINTHAASPLRKSTSAAFGRDGERSANRGRDSLGGAFERRASPSKKDVSPLKRISLGNAERERSERSLGQTDRLGRSTGFGGLNLGKREGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2C9</accession>
    <name>M2T2C9_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_92303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
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    </dbReference>
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    <dbReference type="GeneID" id="19141441"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92303"/>
    <dbReference type="HOGENOM" id="CLU_171219_1_0_1"/>
    <dbReference type="OMA" id="SAICKDY"/>
    <dbReference type="OrthoDB" id="3690319at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WSC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="65" mass="6905" checksum="D69114418F40D6BB" modified="2013-05-01" version="1">MTRQKCAAICKDCLYFALGHTKECWCGDAFHTATELVNDGACSAKCGGDKTHACGGDGMLPIYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2E4</accession>
    <name>M2T2E4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_37160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700355.1">
        <property type="nucleotide sequence ID" value="XM_007702165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2E4"/>
    <dbReference type="STRING" id="665912.M2T2E4"/>
    <dbReference type="GeneID" id="19138915"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37160"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_18_0_1"/>
    <dbReference type="OMA" id="HSTIDFI"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="203"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="468"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD63381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="631" mass="69505" checksum="1588CAC29B99AC08" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2Z0</accession>
    <name>M2T2Z0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_277091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696328.1">
        <property type="nucleotide sequence ID" value="XM_007698138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2Z0"/>
    <dbReference type="STRING" id="665912.M2T2Z0"/>
    <dbReference type="GeneID" id="19135734"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_277091"/>
    <dbReference type="eggNOG" id="ENOG502SH4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="OMA" id="SSGASWH"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026037" evidence="3">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="239" mass="26881" checksum="67E2BA4C6A23C074" modified="2013-05-01" version="1">MKVVSFILSALASLTAAQQATLCKDFEYYSSNGYELNNNIWGRSSATSGSQCTYVNSVSQTGAKWTSNWQWQGGRDNVKSYVYSGRQITKKPVSQYNNLETEAYWVYDTNNIRCNVAYDLFTSANVNHPTSSGDYELMVWLGRYDVYPIGSSQGMVNVAGRQWELFYGLNGNMKVYSFVTPSGPIYNFKASMKDFFQYLANNKGFPITSQNLITYQFGTEAFTGGPAKFTVNQWSANAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T446</accession>
    <name>M2T446_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_161176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700803.1">
        <property type="nucleotide sequence ID" value="XM_007702613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T446"/>
    <dbReference type="STRING" id="665912.M2T446"/>
    <dbReference type="GeneID" id="19132085"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_161176"/>
    <dbReference type="eggNOG" id="ENOG502SMMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_0_0_1"/>
    <dbReference type="OMA" id="MRDTWNA"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="220"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD63792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="318" mass="34501" checksum="855EF0B0541AE296" modified="2013-05-01" version="1">MASATATKLNRKALIGSSTSFWSHTSQLGFDLTHPSTHSSPISDPNYTIQTSAQPIKVDPAKSALIIIDMQNFFLSEAFGRNQQGAGHAACEQLVKHAIPAARKSGIRVVWVNWGLTEEEVKEMPPAVKRAFGFFAIPADSDFNADDAFGYHKSSVSVDRHGEENKSMYCGIGAECGTLALPDGKYVSGGRLLMRDTWNAALYPPLDAMYTEGGKLDSRPDVWIHKNRMSGLWGATTPLKEFLDQEGIRTLFFTGVNTDQCVGGTLTDAFSNGYDCVLLSDGCGTSSPEYAQQCWEYNASKTFGFCASCEQFANGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7G1</accession>
    <name>M2T7G1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_141779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699635.1">
        <property type="nucleotide sequence ID" value="XM_007701445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7G1"/>
    <dbReference type="STRING" id="665912.M2T7G1"/>
    <dbReference type="GeneID" id="19131215"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_141779"/>
    <dbReference type="eggNOG" id="ENOG502S90K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014251_1_0_1"/>
    <dbReference type="OMA" id="FTSWAEY"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF5">
        <property type="entry name" value="TAIL SPECIFIC PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026166" evidence="2">
        <location>
            <begin position="22"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="4">
        <location>
            <begin position="166"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="3">
        <location>
            <begin position="380"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="899" mass="97531" checksum="7AED8AEDADE97F01" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2T930</accession>
    <name>M2T930_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_114914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698814.1">
        <property type="nucleotide sequence ID" value="XM_007700624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T930"/>
    <dbReference type="STRING" id="665912.M2T930"/>
    <dbReference type="GeneID" id="19130263"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_114914"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_2_1"/>
    <dbReference type="OMA" id="QMFMQAS"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="174"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="320"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="45665" checksum="22F041DED5F952B9" modified="2013-05-01" version="1">MSSKPQIGFCGLGAMGIGMATHLVKQGYPVTGFDVYPPSLEKFAKAGGTPSSSLSASAKDKPFYIVMVASAAQAQPALFDADGIVNALPQGATLLLCSTVPSAYAQAVEKELVEIGRSDIAFIDAPVSGGAIRAADGTLSIMAGASAASFEKGQFLLEEMSAPSKLFIVNGGVGAGSNMKMVHQVLAAIQILSLNEAYGFAARMGINGQDLYDEVVGKKDAKAWSWMFENRSQRTLKEDYFPGASAVTIILKDTGIITSSARAAAFPTTLCSVAEQVYFSALDRGWGANDDAGLVRLWTSDPVTSIQSTLSPEEKAQKLEHAVNLLTGIHLVAATEAISLAKHVGIPLPQFYTLVCDAAGGSTMFKEAGQKMIEILEGKEDGSGSVLGGYVETLKLAVEEAQSIKCPVYLGSAALNKLLESGKELSLKGLLACYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9N8</accession>
    <name>M2T9N8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_25534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase_C50"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036864">
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="SEPARIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00906">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="9">
        <location>
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            <end position="2044"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="2509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
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        </location>
    </feature>
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            <end position="2507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EMD65677.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBC7</accession>
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        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <location>
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            <end position="401"/>
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        <location>
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            <end position="86"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007699914.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19136175"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_301069"/>
    <dbReference type="eggNOG" id="ENOG502QU5N">
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    </dbReference>
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    </dbReference>
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        <location>
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    </feature>
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        <location>
            <begin position="39"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
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        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="382" mass="43388" checksum="795CF45EE8586D24" modified="2013-05-01" version="1">MSKTKTKRARRELKCEGERKIAAHHRKAAAKAAETKQATTKPPAKKKQKMNSTTAKDAPPATKPAHVQPSQRKHAIPFGEYDHILLVGEGDFSFTRSLAIEHGCANVTATSYDSREDVESKYPTFGPISTELSSLTPPVPLFHSIDATKLSSYKHLRCKRDDDDDGEEGWDTIAFMFPHTGGLSTDVNRQVRANQALLVEFFKSCIDTKDAKRRLHILQTQKREKEESRKRKRDQSQGDSQQEQRKQQSVKPFLRIGGKIIVTLFEGEPYTLWNIRDLARHVGLRVVESWKFDWEQYPGYHHVRTLGALEGGGGWKGEDREARMYVFEKIPLVADSDEEKEMERVAKVARGGRLPSQKEAMKAALQGDEEKDDEEEDEEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFW6</accession>
    <name>M2TFW6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_33102</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695453.1">
        <property type="nucleotide sequence ID" value="XM_007697263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFW6"/>
    <dbReference type="STRING" id="665912.M2TFW6"/>
    <dbReference type="GeneID" id="19137039"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33102"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_4_3_1"/>
    <dbReference type="OMA" id="EQNCIDR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000069">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="189"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="86"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="337"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="425"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="502" mass="55513" checksum="C79198E86E3964D1" modified="2013-05-01" version="1">MRAFRHSLTECTANPTKSLRPAVLSSCRNYAQPAFAPKPTIDIKHIRQNPGLYEQNCIDRNYGAHSKSPWRIIELHDQWLALQQSSRNLRERNNQLRAKLARAAVQAKNGDGQSAALQKGTIADAKALKEELSSIEAQETQIQDEIEALAQDLPNLSSTHTPVGADFEVVGYINAQSESEPLQSQSRKSHVDIGQELGILDFTGSSQTSGWGWYFLVGDGAMLEQALVQYALSVARNKGWKAVAPPSIVYSHIAAACGFQPRDQNGEQQIYAIEQSEKDKAKPQLALAGTAEIPLAGMYANHKFEQAELPLKTVGVSRCYRAEAGARGANTKGLYRVHEFTKVEMFAWTLPDHAGEDYFAAQPASSSEAVFDEMLTIQKEILEALGLQCRILEMPTTDLGASATRKLDIEAFFPSRREKDQGWGEVTSTSMCTDYQSRRLQTRVRVKGKLEFPYTVNGTALAVPRVLAAILENHWNEQERTVTIPEVLRPFMGGQAKIGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2THL3</accession>
    <name>M2THL3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_270099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695871.1">
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Ohm R.A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694797.1">
        <property type="nucleotide sequence ID" value="XM_007696607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLD5"/>
    <dbReference type="STRING" id="665912.M2TLD5"/>
    <dbReference type="GeneID" id="19133934"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_195289"/>
    <dbReference type="eggNOG" id="KOG1993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003886_1_0_1"/>
    <dbReference type="OMA" id="SFHYVFH"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1045" mass="118026" checksum="F86FEE257DBF6DB3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2TND5</accession>
    <name>M2TND5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="10" type="ORF">COCSADRAFT_132828</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695307.1">
        <property type="nucleotide sequence ID" value="XM_007697117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TND5"/>
    <dbReference type="STRING" id="665912.M2TND5"/>
    <dbReference type="GeneID" id="19130869"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_132828"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="OMA" id="QCHLGAK"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="205"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD70192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="299" mass="32203" checksum="44435063B24420DA" modified="2013-05-01" version="1">MAPSNLPAIFNPTQQDIEMLLAAQCHLGSKNLQVHMEPYLWKTRPDGVNVLNIGKTWEKIILAARIIVAIDNPADVCVISARPYGQRAVLKFASHTGATAIAGRFTPGNFTNYITRSFREPRLIVVTDPRTDAQAIKEASYVNIPVIALCDGDSPTEYVDVAIPTNNKGRHAIGLVWWMLAREVLRLRGTLANRETEWDVMTDLYFYRDPEAEENKDSAGVEEAKVPGADEVGPAAVADGFTSEWEVSGASAGAFTAQAAAPGTSWDADAADWAASGDAQASGEGWGAETAAPATTTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2QTE0</accession>
    <name>M2QTE0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_279103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705888.1">
        <property type="nucleotide sequence ID" value="XM_007707698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QTE0"/>
    <dbReference type="GeneID" id="19135769"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_279103"/>
    <dbReference type="HOGENOM" id="CLU_2385997_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024252" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10889" checksum="4027B099F0AC7D77" modified="2013-05-01" version="1">MWRGRSCAVVGIWMLRGVLRSTVHTCSWRIDLRFVCYTSAMYVHAFMHAERERERERERERERGTDGRQAARSALVVLASPSQTRGAACCVTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZM1</accession>
    <name>M2QZM1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_99251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703848.1">
        <property type="nucleotide sequence ID" value="XM_007705658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZM1"/>
    <dbReference type="STRING" id="665912.M2QZM1"/>
    <dbReference type="GeneID" id="19141844"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99251"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD60519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="126" mass="13737" checksum="6E8DAF8D0D30EF3A" modified="2013-05-01" version="1">MAEDNSAAWPQADQALSQEILDLVQQATHYRQLKKGANEATKTLNRGISELIILAADTSPLAILLHLPLLCEDKNVPYVYVPSKMALGRACGVARPVIAASITTNEASDLMGQIRTLKDKVERLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2R0Y3</accession>
    <name>M2R0Y3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_237749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703318.1">
        <property type="nucleotide sequence ID" value="XM_007705128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R0Y3"/>
    <dbReference type="GeneID" id="19134916"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_237749"/>
    <dbReference type="HOGENOM" id="CLU_2061272_0_0_1"/>
    <dbReference type="OMA" id="CGPRCFR"/>
    <dbReference type="OrthoDB" id="3690641at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="119" mass="13523" checksum="39025BED9DD1E556" modified="2013-05-01" version="1">MAAKQACLPNALALPGRAVRVLCGPRCFRCVLTKTSQCRPPIQLWPAKPLVSRPRLQMPKSLHHQHPFSQQHPFCTRFPALFRPSTALPALFLHFWRHLRIPFLSSSPSPRPLSTPIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2R334</accession>
    <name>M2R334_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_39313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702622.1">
        <property type="nucleotide sequence ID" value="XM_007704432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R334"/>
    <dbReference type="GeneID" id="19139470"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39313"/>
    <dbReference type="HOGENOM" id="CLU_2867517_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="64" mass="7355" checksum="E1208DE9D808D922" modified="2013-05-01" version="1">MRARVSDTRMTHADRWWARFLNGFSQKRTGMGGAGRLTKNGHLDLRGCDCEFCCRVSHLPVPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2R401</accession>
    <name>M2R401_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_162462</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702296.1">
        <property type="nucleotide sequence ID" value="XM_007704106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R401"/>
    <dbReference type="STRING" id="665912.M2R401"/>
    <dbReference type="GeneID" id="19132182"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_162462"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="OMA" id="CYRSWVR"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="220"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="422"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD61934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="679" mass="70981" checksum="682E94708F6A3A01" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2RAR2</accession>
    <name>M2RAR2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_144554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700925.1">
        <property type="nucleotide sequence ID" value="XM_007702735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RAR2"/>
    <dbReference type="GeneID" id="19131318"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_144554"/>
    <dbReference type="eggNOG" id="ENOG502SAC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154032_0_0_1"/>
    <dbReference type="OMA" id="VQACTYC"/>
    <dbReference type="OrthoDB" id="2818448at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024270" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10426" checksum="16B7B2E49BB3C22B" modified="2013-05-01" version="1">MVRILSLATLLIASAITTQAAMFCQCLFGDGSHCCVYSDPQIGNLDCQRWCTNAHRADGATNPRNPLEVGTACNSNGKYSTVSGWNAQFRTSCYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBD7</accession>
    <name>M2RBD7_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_36718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699778.1">
        <property type="nucleotide sequence ID" value="XM_007701588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBD7"/>
    <dbReference type="STRING" id="665912.M2RBD7"/>
    <dbReference type="GeneID" id="19138806"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36718"/>
    <dbReference type="eggNOG" id="ENOG502S3AM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="OMA" id="VHPHTRF"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024673" description="DJ-1/PfpI domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="122"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="269" mass="29185" checksum="A63BFAFF7C4B3348" modified="2013-05-01" version="1">MYFCQKAYLAAAAAACTLISPCLSTPVQPPITNTSALPVHYGLVIFPHYQALDIFGPMDLVNSLFMTYRNKTKEPHISVLSRTMDPVSSAMMPGGFGEAILPTTTFKQYLSDHAPANDTATSVDGKPDIDVLIVPGGGGTRNDMSEEIAFIAATFPRLKYIISICTGASLLSRAGVLEGRRATTNKRSWAWATSHGNNITWIPTARWVQDGNVWSSSGVSAGIDAMYAFVSSVYGEDVATFLSLSLEYTRELHWYEDPFAAVWDVPGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2RCY6</accession>
    <name>M2RCY6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_115541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699273.1">
        <property type="nucleotide sequence ID" value="XM_007701083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RCY6"/>
    <dbReference type="GeneID" id="19130286"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_115541"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="OMA" id="AQQYVAF"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024467" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD64664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="551" mass="59576" checksum="23720AB16067720D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2RG67</accession>
    <name>M2RG67_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_86460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698817.1">
        <property type="nucleotide sequence ID" value="XM_007700627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RG67"/>
    <dbReference type="GeneID" id="19141112"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86460"/>
    <dbReference type="eggNOG" id="ENOG502S978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="MDVSYEG"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="269" mass="29396" checksum="74E4EE3FDF0765E8" modified="2013-05-01" version="1">MAPLRKYLRITKHSVIEVRIYLDRPADADAWLLKRDDPALPRVIQAVQPLVLPKLREENERGKGRGGAKAKKKGVKDVVIQDDFEVSIFLTELSSRHSVLTKQKIFKDKARIQSNSGKLTGWLTSGTSDQPVVINEDAAEPITIRQEDNSGAVNLFDIPEAKTAKKQHSEASDSETSDLIVSEQASITGNTAQDQDEGQRGDETKKLGLRTSYDGFSIYGRILCLVVKRRGARNAAPASGAASGSQAMLENWVSTQAVAGQQDEDDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2RH94</accession>
    <name>M2RH94_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_197610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697668.1">
        <property type="nucleotide sequence ID" value="XM_007699478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RH94"/>
    <dbReference type="GeneID" id="19134025"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_197610"/>
    <dbReference type="eggNOG" id="ENOG502SIZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013935_2_0_1"/>
    <dbReference type="OMA" id="NECRLLY"/>
    <dbReference type="OrthoDB" id="3549294at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="498" mass="56321" checksum="9C85EEC002FA248D" modified="2013-05-01" version="1">MDDEVRISEKQFRNTYAAGFETWAQLYSLIVKDAKLPSHCFFTKNTFPLLPTFPQSLELEEHSNGLTASGFSTWGSLPAKCARCIPSFRRRVQLEVAVKDPVLLSISDLAPTDSYSTSWFNSQNDYVTVLVLAWTYILSARWAEIMSPACSLTYTNNLAKHYDATTISNNPQHFIDSISTFSEAFGFLSRFCTRHNIVDQSHAALAAVLLLPCNTNGIRPLLLSIFYEPSIECNAVTPWLQGTLAAIESLAGEKLSIFGRMCMERRPEVACIWLGSAILGLQPKLLQDVKYGQIPIDLDSAAWTGTIQSFIQQPVSRPLTVNGYIQRADECRLLFLCQSKNHTRTPICQWKPFGKTPKDDVDLEVKVHEHCEGHGLQYQEFVWDCTEGELKLPSLQLCPHGIQGQPSIRKAQCTVPVVWKGLNHEKEAISENATRNIFSWLRSDGYAPCEKAISKHEWFMTYDSDEEQELIEEKTSMNDLKDVKKIEEWLTCSKESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2RHL0</accession>
    <name>M2RHL0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">COCSADRAFT_34799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697507.1">
        <property type="nucleotide sequence ID" value="XM_007699317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RHL0"/>
    <dbReference type="STRING" id="665912.M2RHL0"/>
    <dbReference type="GeneID" id="19137874"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34799"/>
    <dbReference type="eggNOG" id="KOG2420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029061_1_1_1"/>
    <dbReference type="OMA" id="HSPASWV"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023394175" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023394174" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="490"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="93"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="489"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD66229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="544" mass="60971" checksum="DA08F903DB11D6B2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJ78</accession>
    <name>M2RJ78_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_302064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_302064"/>
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    <dbReference type="OMA" id="CCFWCSL"/>
    <dbReference type="OrthoDB" id="3690794at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32830" checksum="19E43242D1BDE413" modified="2013-05-01" version="1">MERIAYFHSAHTEPIMSTSALWPSGHPNVLRRGSQSSSRSEEMRTLKHPQTSSFNRLPTELILKICGHISAHDLWHNIRPTSRLLAICAREVLPRKVFSESKIHISWCCFWCSLGRHCLHTACNPITWLFPDAKNVRVALISDRATIAKVIFGDLCNLVTSYEPKIRIRLGEEAQGVRCRSKAIRPRIQPHTADSASNLQSRQEEFVMWYFATQRRQRARSRILRCLGFAAHLLRFFTTSAVLLSVGLTLTLVVYVILEICKLGMSCYRSGRNFMRFCMGKFPLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2RME9</accession>
    <name>M2RME9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_24141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Han J."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Bushley K.E."/>
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                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="6182" checksum="82B1B0D49B0873C9" modified="2013-05-01" version="1" fragment="single">VINNVLYKYLRIFITTYLDNILVYSSGTREEYIKYVKKVLRKLKEYKLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSA4</accession>
    <name>M2RSA4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_176814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445730">
        <property type="protein sequence ID" value="EMD58103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706196.1">
        <property type="nucleotide sequence ID" value="XM_007708006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSA4"/>
    <dbReference type="GeneID" id="19133052"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_176814"/>
    <dbReference type="HOGENOM" id="CLU_2346538_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="97" mass="10673" checksum="4F7A1014CAB883A9" modified="2013-05-01" version="1">MLYSASYSSSIRLTLRSPPNISYSIPQQYGHICYASSFSFAHTTLSYTAYSCASAYHASYPLVSTIVVVASTTTSYYIASYILPALRQLQLSHHATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT57</accession>
    <name>M2RT57_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_131903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694980.1">
        <property type="nucleotide sequence ID" value="XM_007696790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT57"/>
    <dbReference type="GeneID" id="19130830"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_131903"/>
    <dbReference type="eggNOG" id="ENOG502SMXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040076_2_0_1"/>
    <dbReference type="OMA" id="GPMFADD"/>
    <dbReference type="OrthoDB" id="5343688at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="362" mass="40005" checksum="4CD6C31E070976C7" modified="2013-05-01" version="1">MRRQLPPTHLKVPPGPHAFPRQQFLGQETVVVNHYAGIEKAIPAIPSLPGFRTSAAFLTSLSANLRIDPDLPSPLPTPTNFRLNTFIQPVPPTSLSYSTSTAPYNPYISTAESHVMSSTVASAPEKAPADELPQLSTYTAETEDDRIEGLRLVADSVAQQRQVASKMMMFHPISLAAYFVAVAIAAQYMLRWYEDKLMLVTTIGGISMTFLIFIRWMTGGYISLAEDINMDWLGDDRLIVVKWGEDVIGSLVLGWADNDAAKKRGRRRRGKAVVRAWTVKLKYRGKGVGEGLLEEAVRVAGERGADGILFDPDHANSKRILPLIFNGFLNKQEAKAEKALQKVADAKGNFRQRQSSPTWGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2RTA2</accession>
    <name>M2RTA2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_41909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705811.1">
        <property type="nucleotide sequence ID" value="XM_007707621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RTA2"/>
    <dbReference type="STRING" id="665912.M2RTA2"/>
    <dbReference type="GeneID" id="19140116"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41909"/>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031077_1_1_1"/>
    <dbReference type="OMA" id="FKWKFSS"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="36297" checksum="FB4C94D6D207ED17" modified="2013-05-01" version="1">MSYFFSTPVDIDIVLEDLDDRSAVDVKLDKNRKEKVPLYLDGESVKGQVTVRPKDGKRLEHTGIKVQFIGTIEMFFDRGNHYEFLSLGQELAAPGELQHPQTFDFNFKNVEKQYESYNGINVKLRYFVRVTVSRRMADVVREKDLWVYSYRIPPETNSSIKMDVGIEDCLHIEFEYSKSKYHLKDVIVGRIYFLLVRLKIKHMELSIIRRETTGAPPNQYNESETLVRFEIMDGSPSRGETIPIRLFLGGFDLTPTFREVNKKYSTRYYLSLVLIDEDARRYFKQSEIVLFRQAPEGLTLAQEQNKLMAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUC4</accession>
    <name>M2RUC4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_165029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705274.1">
        <property type="nucleotide sequence ID" value="XM_007707084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUC4"/>
    <dbReference type="STRING" id="665912.M2RUC4"/>
    <dbReference type="GeneID" id="19132351"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_165029"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_14_1"/>
    <dbReference type="OMA" id="EREHSHE"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="123"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="499" mass="57464" checksum="A5717BFBF8837E12" modified="2013-05-01" version="1">MQRQLRREDYTVGWVCTLPVELAAVKTMLDEKHTDASRDVGDDDENVYTMGSITGYNVVINIAANHHFLIMLPISAQRSLSSRTQRMALQNNELFPRQSLLESLRFDQIDARQMTIKTAHAKTCRWLLQSEKYLNWLDTTKLDKHHGFLWIKGKAGTGKSTLMKYALVNARKAMENHIILSFFFNARGEDIEKSTIGAYRSLLLQLLENLPALWNVFNSPSFLKVTKDHQWNIETLKTLLEQAIQSLGDSSVVCFIDALNECEEEQVRDMVQFFEHIGDLVVSHGIYFQVCFSSRHYPYITIRNGLELVLEGHEGHSQDITNYVETELKIGKSKTAQQIRTELQEKSSGIFIWVVLVVGILNKEFNRGQVHLLREKLNAIPGDLHKLFSDILTRDSRNKDMLVLCIQWVLFAKQPLSPEQLYHALLLNINSNAISKLDPEETTKHDMKRFLLDFSKGLAEATVSKEPRVQFIHESVRDFLLKENGLSKIWPKFRSNFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2RVA6</accession>
    <name>M2RVA6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_262750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705466.1">
        <property type="nucleotide sequence ID" value="XM_007707276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RVA6"/>
    <dbReference type="STRING" id="665912.M2RVA6"/>
    <dbReference type="GeneID" id="19135466"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_262750"/>
    <dbReference type="eggNOG" id="KOG1425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022379_0_0_1"/>
    <dbReference type="OMA" id="YRDMKTE"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="121"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="411" mass="46645" checksum="430F476296A51B92" modified="2013-05-01" version="1">MPPPKSKKLTAQPVRTRQFAGKPAIAEPEEHSSSESESEDEQKPQSKPFAKPKPAPIASSALKSRLASRQKSEDARKALEEEFETESEDDEGKDGNGSGSGSGSSSGSGSDEDESSEEESSSEDEAPKKLLRPVFLKKSERNKIAAPVKSADELAAEEEARRQEQARALVQEQVEQRIAEKAAGKKDWDDDIEDTDINAIDDTDGVDPDAEYAAWKLRELKRIKRERLAIEEAEAERAEIERRRNLSAAEREAEDREFIEKQKEEKGDRGQMQYMQKYFHKGAFFTDELKELGVDRRNLMNARFEDDTNREILPEYMQIRDMTKLGKKGRTRYRDMKTEDTGKWGDFGDDRPRRDKGEYGVDERFRPDGHGARDRDRDGATGANAKPLGERKRFGESNDRDSKRPKIQDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2RX45</accession>
    <name>M2RX45_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_126950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007706441.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19130673"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_126950"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_005533_0_1_1"/>
    <dbReference type="OMA" id="PLPANWG"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COMT-like"/>
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        <property type="entry name" value="COMT_dimerisation"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="281"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD59613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="475" mass="52909" checksum="EE981C62567BDE57" modified="2013-05-01" version="1">MDFNSTTNKLMQLEALLHSALATLGVSSVNYKNSLPPRALFDAQRTILAAVGMITELVSTPSVRLLEVSMQYFEARALHITAEKRIPNMLAGCDENGVAVKELAEQAGCDALKLSRIMRCLCSIHIFKEVQPDRFANNEVSAALVNNEPLRAYIVMFAFDLYSASDHLPRSLFDKKMGPSYDVAETAFQKALGTHKPRWEWFEDKITVQNLLDGRCGTDGGQSGYPGPFGSELDKAVEGKAGSELIGRPELPIFGLAMVGGGRVLGKAHLYDYPWESLGSACVVDVGGGVGGFCLQLSQVYPQLRFVIQDRAPALEQAETVIWPKENPDAIAQQRVQFYPHDFFEPNPVKEAEVYWLRYIMHDWSDEYCVRILKAIKPSMGPRSRILICDQVMNTTLGSEELTAAPSPLPANWGYYTRYSHQRDLALMAAINGIERTPREFRTIVEKSGLKLLKIWDCRSQVSLVEVVLPESELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXH4</accession>
    <name>M2RXH4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_164631</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704741.1">
        <property type="nucleotide sequence ID" value="XM_007706551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXH4"/>
    <dbReference type="STRING" id="665912.M2RXH4"/>
    <dbReference type="GeneID" id="19132328"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164631"/>
    <dbReference type="eggNOG" id="KOG2817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020227_0_0_1"/>
    <dbReference type="OMA" id="FEATNND"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="13">
        <location>
            <begin position="168"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="14">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD59758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="417" mass="47648" checksum="E040DBED018FDCFD" modified="2013-05-01" version="1">MDDLREQVELLEKSANLSASIDHVQKAIDMLTAARAKIAADPTTAPLTLARLQDPFKQSLDTVQKDLKPIYSGLNKYGKALDKKFKDKPLPSAENDALSSHPSLINRAIAMHLLREGQFDVASTFVQEASRQPPRPEPTPNTPNPHIRESWERDLAEGTFNSEELQQKFAEMYHILHELRVQRNLQPAIQWARQRSAELEGRGSNLEFELCRLQYICLFDSHNQHSDAMDTEIPNGPLDAWAYAHREFPPFYKRYAREIRQFLGATAFWPNIQDSPYRRLFYNESAWEEVAHSFNREFCSLLGLSADSPLFIAATAGAIALPYLLKMQSIMKEKRTEWTTQDELPVEIPLPSQYHFHSIFVCPVSKEQSTDTNPPMMMPCGHVIAQESLDKLSKGSRFKCPYCPNESHPREARKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXQ9</accession>
    <name>M2RXQ9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_100400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704162.1">
        <property type="nucleotide sequence ID" value="XM_007705972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXQ9"/>
    <dbReference type="GeneID" id="19129693"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_100400"/>
    <dbReference type="HOGENOM" id="CLU_3111885_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="51" mass="6201" checksum="3ED488276F32ACED" modified="2013-05-01" version="1" fragment="single">IASLKKANEAIIKRRQRKKKRIQKQRVLTKRAREDLLAQRKANQQITYKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2S042</accession>
    <name>M2S042_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_193287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703929.1">
        <property type="nucleotide sequence ID" value="XM_007705739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S042"/>
    <dbReference type="GeneID" id="19133842"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193287"/>
    <dbReference type="HOGENOM" id="CLU_1481860_0_0_1"/>
    <dbReference type="OrthoDB" id="3687185at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="182" mass="19710" checksum="1DC053D32D190151" modified="2013-05-01" version="1">MAAALCSRQYVHVHYVCGCARASWAGMRAKCREYCCNAGGQQALLGGWACTLRRLPARSSQMPRRLTPPVQPLAWLFLAAVTARPVHWISTLPNSPPSKPYPLAASRPSRRLSFSRPSPSARALLALANCSALADKLYSSISHDSLVNTMILRESESNNMGRGAYDTTGTPKPSPTTTPPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2S1L9</accession>
    <name>M2S1L9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_345260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703446.1">
        <property type="nucleotide sequence ID" value="XM_007705256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S1L9"/>
    <dbReference type="GeneID" id="19137698"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_345260"/>
    <dbReference type="HOGENOM" id="CLU_767285_0_0_1"/>
    <dbReference type="OrthoDB" id="3792817at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="361" mass="40487" checksum="09B18C5D9E46CC9A" modified="2013-05-01" version="1">MAANMVKKGMNEKPGRDKATQQRGYMFGLKATHTLEIGVACHYRGHYIYAYPSSVPIDPILFATKTGVNVAGIKRSCASAHDPCDSGLVDKSRIHALERSCFHEREVQREHMKKMKKRRLDMKDEAVQAAYERISDMVQRLLDPKHSQFWEQPLGNGLYLMQLRKVFHLLVRLNAKSGFEYKHASILFTRDNIVVENSNDTKSANNSERTDDTENGVLVEFIEPENPVFQQRATSVLFASAQEKLSRLPSPTLDEQQRNIYIDRSDIAIWSAGGGCGLQSDFSSCDEIEGPVRRRPRVQTRGEGAPLVAIDTNSCDCRERKSQLPTAFVGSRATAEEYEAALTTIPAARRCDPRLPGQTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2S1T6</accession>
    <name>M2S1T6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_345310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <source>
            <dbReference type="EMBL" id="EMD62898.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="62" mass="7071" checksum="BE9690CE1438F706" modified="2013-05-01" version="1" fragment="single">RRVYLLTPNNYILLTVTECVNAVGYAILLIIIIKGDALLERYFTNLPNNYLIAYSDSGYIND</sequence>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701486.1">
        <property type="nucleotide sequence ID" value="XM_007703296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7W6"/>
    <dbReference type="GeneID" id="19137399"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_339915"/>
    <dbReference type="HOGENOM" id="CLU_2468921_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="88" mass="9416" checksum="5945249727EB7264" modified="2013-05-01" version="1">MSKPIPSTCLAQKTVPALSSKQKHIHTHIHTYTHLHIHPSTLPDHAPALSPHQVLALCPPGPAPASHAAPAPPTLLHLLHCSSWAHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8E6</accession>
    <name>M2S8E6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_171850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700663.1">
        <property type="nucleotide sequence ID" value="XM_007702473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8E6"/>
    <dbReference type="GeneID" id="19132764"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_171850"/>
    <dbReference type="eggNOG" id="ENOG502RYF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044619_0_0_1"/>
    <dbReference type="OMA" id="HDWETFA"/>
    <dbReference type="OrthoDB" id="3466836at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="64"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="361" mass="40330" checksum="13C7D8710B08C89B" modified="2013-05-01" version="1">MSARSYPIPFPGENTEDDDLAPFPEPEVSSLALDTKPGAQIHYTYYPASKSQGNNPNPFSQTLIVFLNGAMMPRSSWDAAIRSFLEKRITGRLPYPGLLSYDRYGQGESDPDPDDPHPPPSHGHDAISAVKALKQFTLQIWREHLDINKPTHYPCLIFVCNSLGCALARLFAQCYPGTVSGLLFLDSIMANSDYQAFWPDPDAPDFDPHILPDDVTADQVRAVREKYRSMLHPDVPSPEGLSRRNLAKLLPDAGAPKLEGYLGRGPYLTVVGHDWETFAEQSSNPPLNVPKALTMTYANPAWRRYNEELCHITEEGKAIGPITAVRCGHFIQRDDPRFVSDEMVSLLDRVVNRVQQVSNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAI2</accession>
    <name>M2SAI2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_26505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699721.1">
        <property type="nucleotide sequence ID" value="XM_007701531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SAI2"/>
    <dbReference type="GeneID" id="19135507"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_26505"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019364_0_0_1"/>
    <dbReference type="OMA" id="PAWGAKQ"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="290"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD64348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="536" mass="59412" checksum="3A6F702FD144DDCE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAP3</accession>
    <name>M2SAP3_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_36970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699837.1">
        <property type="nucleotide sequence ID" value="XM_007701647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SAP3"/>
    <dbReference type="GeneID" id="19138865"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36970"/>
    <dbReference type="HOGENOM" id="CLU_1626896_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="163" mass="18269" checksum="D4916C982094DBED" modified="2013-05-01" version="1">MCVCVCVCVWSEVGTPHLAYRLQRKPTFTLPFIPPSPSNNPIDPNQLQYSNPQFKLSILSIPIPRTNISTPQPPFHHMFYNSHKSKKNPRVRESKNNAFATREPPIPDPTFLPAHPSTQTSRPFPTHNGFEKAQFFSSLAFLLSGCADGSETACAPQHISKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB69</accession>
    <name>M2SB69_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_118053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700294.1">
        <property type="nucleotide sequence ID" value="XM_007702104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SB69"/>
    <dbReference type="STRING" id="665912.M2SB69"/>
    <dbReference type="GeneID" id="19130373"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_118053"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015320_2_0_1"/>
    <dbReference type="OMA" id="SNCKARN"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="361"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD64543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="420" mass="44942" checksum="8A3509D1F3ABE986" modified="2013-05-01" version="1">MGFSLNNPLPSSMASECRKTGKILASFVDPRQAFGPDKIIPPNVLANAKGLAILTVFKAGFLGTARFGSGVVVARLADGSWSAPTAIGTIGGGFGGQIGFELTDFVFILNDASAVRTFAQAGSLTLGGNVSIAAGPVGRNAEAAGAASLKGVAGIFSYSKTKGLFAGVSLEGSGIIERRDANEKLYGRRWTAREILSGQVPPPPAAEPLLRVLNSRVFSGVGGAQNVTNDAMYNDIPVYDDAHDNVVWQGRRGSAMGEGVRRDRTGSMGSHHDDYQYRDHQQTSSWADDVYDRQPSSAPSGLNRSYSTRANPTETFDRIDSRNRASTFGDDYYSYSDRKPGRPSAPKPVFGQTTGQKKASLQSDQAIAKFTFDADQPGDLGFKKGEVITIIKRTDNETDWWTGRIGSREGIFPSNYVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCL3</accession>
    <name>M2SCL3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_250036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_250036"/>
    <dbReference type="HOGENOM" id="CLU_2359399_0_0_1"/>
    <dbReference type="OMA" id="QEAFPPP"/>
    <dbReference type="OrthoDB" id="3688608at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
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            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD65558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SE68"/>
    <dbReference type="STRING" id="665912.M2SE68"/>
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    <dbReference type="eggNOG" id="KOG1235">
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    </dbReference>
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    <dbReference type="OMA" id="DVMTTMV"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
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            <end position="348"/>
        </location>
    </feature>
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        <location>
            <begin position="409"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="668" mass="75891" checksum="11A19C66071A09EC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEM3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_163328</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007705088.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19132232"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163328"/>
    <dbReference type="HOGENOM" id="CLU_1053711_0_0_1"/>
    <dbReference type="OMA" id="FRRNWAY"/>
    <dbReference type="OrthoDB" id="3795731at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="280" mass="31526" checksum="91EFCD83ECBC3110" modified="2013-05-01" version="1">MSPTVAFLTTFAPLPATTPSSHAHIINDFARGTSTPHLQDAIVTLLYNVSPSTLSTFLEPDIKEFRLVQTRRQGRDAGEELIVMKRSRKVIVGLATHSPDLFDTLEFDNLVRLEINAEGAWKVMYASYRDYFCDSWDDVWDGRTVNRGWDCLSLRAWVEDKRLESRKQLEILAEELMWAPINNAFQHHLHRNGPLHAPHHTNQQPATSNSNTENYTIAFPTLPPNTPETHAHTINLLTPPAHPSLQDTLVTTLFQVSPSTLSRFLGPTVHTFKEVLGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHJ2</accession>
    <name>M2SHJ2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_173287</name>
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    <organism evidence="12 13">
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        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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    <sequence length="1461" mass="161991" checksum="6D35892ADC9A12E8" modified="2013-05-01" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
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        <property type="entry name" value="AGP_Transferase"/>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        </location>
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        <location>
            <position position="411"/>
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            <dbReference type="EMBL" id="EMD62805.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="411" mass="46648" checksum="DD279C3F431FE312" modified="2013-05-01" version="1" fragment="single">PTDLNPSDREHFELFGHNIATVASALHDDVSEVTIEYMRGGSYNRVTGVNITSERRRTNLEWFVSTFGSYLPTQLTEMLKAPKDTGISYIVRIPRFINKETMNIMARDVAILKTVGALVQLPVPRVVRYDLTFQNAIGKPYMIQTRLPGKNFSTLMKDDSLNTEQLLSIAEQVSQLAPIIAAVEGPGGNISLSALSSDSKDLHVESLHLQHEELGDRNFNLAEHPQDTFEHLIETCRRWSEDCTEDGQSFNEIWLNFGIIIKSLNTRGFLNGPCVLAHRDLMPYNLLAEIRNDTQVQITGVIDWDSATMAPEFVAYKAPFWLWTEDHVDSDFADTEECANIVPVTEDAKTIKQVFMENASEKYKHFAFAPEAILARRMYVILKEGIPKDWHIEEAWKIVSEWHALHPEDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLP3</accession>
    <name>M2SLP3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_191424</name>
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    <organism evidence="8 9">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701423.1">
        <property type="nucleotide sequence ID" value="XM_007703233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLP3"/>
    <dbReference type="GeneID" id="19133763"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_191424"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="OMA" id="SWRGDEI"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="7">
        <location>
            <begin position="51"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="496" mass="55105" checksum="BB1B4F1166C18901" modified="2013-05-01" version="1">MAKRKRENGGEATKNGRQKNGEDKPKKKLIINAFVEMCSGHQSPGLWKHPDDRSHEFNNIDHWVDLAKLLEEAKVHGVFIADVIGGYDVYNSNLDAAIRSGAQWPVNEPLAVVSAMAAATKSIGFGVTVSTTYEQPYHLARRLSTVDHLTKGRLGWNIVTSYLDSAARNMGMKEQLPHDERYAQAEEYVKVMYKLFESSWRDDAVVRDRKKSMFSDPNRIRQINHKGKYFEVPGPHICQPSPQRTPLILQAGASKAGKSFAAQNAEAIFVSAHAPVVCKGNIAEIREIASTQFGRDGRSIKFLALATPIIGRTEEEAQAKLAEYRKYASLEGALSLFCGWTGIDLGKYGDEEELRHVDSNAVRSTVEGFARFSPGTSKWTKHTVAEHISIGGIGPIFVGTPSQIADGFQTWVEEADVDGFNIAYTLFPQSFKDVAELLLPELRKRGVFWDDYAVPGGTYRENFYGTKGQTGPPDEHVASTYRWKTGVDAKDHVIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SME5</accession>
    <name>M2SME5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_41981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445657">
        <property type="protein sequence ID" value="EMD58316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705957.1">
        <property type="nucleotide sequence ID" value="XM_007707767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SME5"/>
    <dbReference type="STRING" id="665912.M2SME5"/>
    <dbReference type="GeneID" id="19140132"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41981"/>
    <dbReference type="eggNOG" id="KOG3937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024943_2_0_1"/>
    <dbReference type="OMA" id="VWQSGGL"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="224"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="471" mass="53233" checksum="2750921156BEFEC6" modified="2013-05-01" version="1">MIPHFSPAHVELCEQPLLKILRNTWFDELFRPSMGPSTINNCVLLLDLPPKALAGIDLLSFTSSPRFRGVRNIPHGLHFVFAAIDGAMSVRHGAWFYVTPGMGSPQVFVKKWDQSTEDLVAETSQTEVLKHKANLGSIWKDGLTPYRQTVQEGDSGTEDGWKEECTDWSKLTTHITPTILSRICGLNPDHWNLTSASSASQDLDDIPGLESSNSMLRPEKELRFLPIDLKKTWREGATGRERTEAAQDRSWFLGDLIDKHCQAGDEQGRENEILGELQFAFLMVLTLNNNSCLEQWRRLLRLLLTCRQAVKERSHLFLDLFKCLRIQLGHCADAEGDLFDMNDAGGGFLRPLLGQFRRGLQDFDGKWKADMVDEVDDLQEYMEKEFGWQPEGSYLKRGMLELEDGERVELEVNGADAEDEVGDYAPTIVDLTPEQHKMLHGTDSGPTKDTRGDAGEESEDDVDLDDMDTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN87</accession>
    <name>M2SN87_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_134547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696168.1">
        <property type="nucleotide sequence ID" value="XM_007697978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN87"/>
    <dbReference type="GeneID" id="19130934"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134547"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="ERPWYTV"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD68613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="524" mass="57719" checksum="DDF6B068741340EF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP83</accession>
    <name>M2SP83_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_36669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699765.1">
        <property type="nucleotide sequence ID" value="XM_007701575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP83"/>
    <dbReference type="STRING" id="665912.M2SP83"/>
    <dbReference type="GeneID" id="19138793"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36669"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="OMA" id="YTVFTPY"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="137"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="389"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="432"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>FAD</name>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Salamov A.A."/>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705503.1">
        <property type="nucleotide sequence ID" value="XM_007707313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPN6"/>
    <dbReference type="STRING" id="665912.M2SPN6"/>
    <dbReference type="GeneID" id="19129825"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102973"/>
    <dbReference type="HOGENOM" id="CLU_2114647_0_0_1"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD59081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="115" mass="13235" checksum="DA48171C6F402437" modified="2013-05-01" version="1" fragment="single">FNAAAQRDSKVQLQIGEEAKREASAMKAIAVVTMTFLPATFISTIFGTNFFSFEVETEAGQSSFAMSRQFWIYRALSIPLTVTTLALWFWWSRWAEHLRLSRPRADAFRDKYISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPT3</accession>
    <name>M2SPT3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_76498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694626.1">
        <property type="nucleotide sequence ID" value="XM_007696436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPT3"/>
    <dbReference type="GeneID" id="19140570"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_76498"/>
    <dbReference type="HOGENOM" id="CLU_2120676_0_0_1"/>
    <dbReference type="OMA" id="FTTWNCT"/>
    <dbReference type="OrthoDB" id="3673434at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025668" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12329" checksum="7B2933D755509B95" modified="2013-05-01" version="1">MHFQTSLSTLLLLTTSTLAYDSISFTTWNCTDCNPVPGTFCSVNTRSQLRPNLCIPMWNGSTYIRTFDATIPSCQVNLYLEDDCTGAVEVHKEDGGRCETKGQTNSFQITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPU3</accession>
    <name>M2SPU3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_153342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705286.1">
        <property type="nucleotide sequence ID" value="XM_007707096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPU3"/>
    <dbReference type="STRING" id="665912.M2SPU3"/>
    <dbReference type="GeneID" id="19131619"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_153342"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_0_0_1"/>
    <dbReference type="OMA" id="HATWPKI"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="299" mass="31939" checksum="452939E7C07480D3" modified="2013-05-01" version="1">MARGGRGGGSRNPANQPREVQVSKKISWLLRHGADQEGLRLGKGGYVNVQDALNTKALQSLKITFAEVRDAVANNEKQRFSMIPVSIQESDDPAEYLIRANQGHSIKVENEGLLVPITTEAGNVPETVVHGTDERAWNLILKSGGLRPMGRNHIHFASGLPAGFKSLDSTSASADAAPVISGMRRGSTILVYVDIDAALAAGIKFFISENGVILTEGNEQGFLPYTFFKRVESRKKDGGVLMSDGKLPEGVTVNVEEWEKEFGQVQKGRGGGGRGGRGGGRRGGKSRAANDSRDTTGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ18</accession>
    <name>M2SQ18_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_194014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704991.1">
        <property type="nucleotide sequence ID" value="XM_007706801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ18"/>
    <dbReference type="STRING" id="665912.M2SQ18"/>
    <dbReference type="GeneID" id="19133874"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_194014"/>
    <dbReference type="eggNOG" id="ENOG502S0IF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036104_0_0_1"/>
    <dbReference type="OMA" id="WYTIKDK"/>
    <dbReference type="OrthoDB" id="3246050at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="520" mass="58184" checksum="99DFEB2180152CC5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQF7</accession>
    <name>M2SQF7_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">COCSADRAFT_153034</name>
    </gene>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD59361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007706901.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SQF7"/>
    <dbReference type="GeneID" id="19131608"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_153034"/>
    <dbReference type="eggNOG" id="KOG3185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pentein"/>
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    </dbReference>
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    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD59361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="246" mass="26395" checksum="A627DA6564C0273D" modified="2013-05-01" version="1">MAVRAQFENSNEVGVFSTLTNAYAIVAVGASENFYSVFEAELQDVIPICHATIAGTRIVGRLTAGNKKGLLVPTTTTDQELQHLRNSIPDEVKIQRIEERLSALGNVICCNDHVALVHPDIERETEEIIADVLGVEVFRQTIADNVLTGSYMALSNQGGIVHPKTSIQDQDELSSLLQVPLVAGSVNRGSAVVGAGMVVNDWMAVTGLDTTATELSVVESVFRLGEGNGPANINTTHKDAMVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQS1</accession>
    <name>M2SQS1_COCSN</name>
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        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_102408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705520.1">
        <property type="nucleotide sequence ID" value="XM_007707330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQS1"/>
    <dbReference type="STRING" id="665912.M2SQS1"/>
    <dbReference type="GeneID" id="19129799"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102408"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
    <dbReference type="OMA" id="EPHCENA"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF172">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="125"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="283" mass="31967" checksum="E4BD76683E174E73" modified="2013-05-01" version="1">MAPHADIDVNHVAQVLEPHCENAELVTISIGKIMDCDRVTEEILLNASKDLGFFYLDIFEHALHNAPRDKPAKLPKEFQQRREAFEAMNHTLGDMGRVILDSLSRSLNLDDKQNLAKHHRKGHASPTALGLLKYLPHEPKSEEVGHVSHTDIGSLSMVFSDIGGLQVYHPGKKTWMFIPPKPGHTVCNIGDSAEFLSKNLLRSSLHRVIPHPAEKGKSKLTVVYLMRPETDTVFVDREGKEWRSVDWHNMKNRLFAEDLESQASNLALTGRLGHDDLWDEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR11</accession>
    <name>M2SR11_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_115678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699314.1">
        <property type="nucleotide sequence ID" value="XM_007701124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR11"/>
    <dbReference type="GeneID" id="19130294"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_115678"/>
    <dbReference type="eggNOG" id="ENOG502SGAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044875_0_0_1"/>
    <dbReference type="OMA" id="LECFHPS"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="3"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="322" mass="36942" checksum="7632BAED571C14C2" modified="2013-05-01" version="1">MEKCYLYRLPNELLLHLFAPMPTLDLLPLTTISRRIYSLILRILHNRLVAAAELNSHSVLLECFHPSAKLTEPPYFCTYRGTDGLKLYHDIDPSEKNVGRLGEMYRMYSRYRPHRRDLEASGRRVKPRPGDVPGSRTFPGTVQDPYDGESVKQMLSLEAHELFTQLIAQTNLVKMGSRNLFTNFVEVEEGVLRVWREWLKDVSARCIADNRIASNEAVEEVGKGKGVVREIVEEKANLEDPSILWVSPRKDSGIRFHARERKLRKNLPILISADEDEDMPVTYEIEFDELLIRTSHLLLMLEKSMLQEDNSSGKAVVFGSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSE2</accession>
    <name>M2SSE2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-NAD kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_36532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699188.1">
        <property type="nucleotide sequence ID" value="XM_007700998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSE2"/>
    <dbReference type="STRING" id="665912.M2SSE2"/>
    <dbReference type="GeneID" id="19138751"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36532"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_1_1_1"/>
    <dbReference type="OMA" id="QKAFKEW"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD65200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55668" checksum="FD118EBF0CF12EB7" modified="2013-05-01" version="1">MATTYFDQLSPGIQGAIESELGDQDSKSIASVNSHDDALEVVFEGGYNGHRRKASLAPHPSGKMTSRPENDRRTTACIVHSLLEKHEGLPVKDHSQSYEGLAQERRVDKDADKERTHEREHSRLLTKKELSDMAFGIRELSKKLSQIRLKLHVKNIFIIGKAHDEGLIKHSHEVTEWLLTKDSAYTVYVEQTLKDNHIFNAKDLLDKDRFKGRLKFWTNEMCAQRPQTFDIVLALGGDGTVLYASWLFQRIVPPTIAFSLGSLGFLTKFDFELYPQSLSRAFADGITVSLRLRFEATIMRSQERDPKGRDLVEELIGEESEDHHTHYSDGTHNILNEVVVDRGPNPTMSSIELFGDDEHFTTVQADGICVSTPTGSTAYNLAAGGSLCHPDNPVVLVTAICAHTLSFRPIILPDTIVLRCGVPYDARTSSWASFDGRERVELKPGDYVTISASRFPFPSVLPLDRRRTDWIDSISRTLNWNSRQKQKAFKEWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSE6</accession>
    <name>M2SSE6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_99920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704256.1">
        <property type="nucleotide sequence ID" value="XM_007706066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSE6"/>
    <dbReference type="STRING" id="665912.M2SSE6"/>
    <dbReference type="GeneID" id="19141881"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99920"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_1_0_1"/>
    <dbReference type="OMA" id="REELMCV"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD60001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="112" mass="11240" checksum="11CE0D5E97DF0313" modified="2013-05-01" version="1">MSTAELASSYAALILADDGVDITADKLQSLIKAAKLEEVEPIWTSLFAKALEGKDVKDLLLNVGSGGGAAAPAAAGGAAAAGGAADAAPAAEEKKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSL4</accession>
    <name>M2SSL4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_180082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698480.1">
        <property type="nucleotide sequence ID" value="XM_007700290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSL4"/>
    <dbReference type="STRING" id="665912.M2SSL4"/>
    <dbReference type="GeneID" id="19133230"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_180082"/>
    <dbReference type="eggNOG" id="ENOG502QQFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_1"/>
    <dbReference type="OMA" id="CATCFFP"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="269" mass="29488" checksum="BEE902BB685FF1C0" modified="2013-05-01" version="1">MLITETHKDVPTEAGGDMRIFIFHPTIPNYPKTKFPGVVVFSEIYQVTGPVARFARQIASQGYIVAAPSSYHEFTGPEPLAYDVPGTDQGNEWKITKTVQAYDEDASLSVDTLLAMSTCNGRIGATGMCLGGHLAYRCALDPRVSAAICYFATDIHSGTLGKGKKDDSIARCKDIKGELVMIFGKMDTHVPPEGRDLIRKALHEAGVTFSFYEPAWAQHAFIRDELSKGRYDAALSGICFEMLKELFNRTLHSDLGPRSGGDVEIEDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSN7</accession>
    <name>M2SSN7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_35377</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="77" mass="8247" checksum="77CD4F1E27928D98" modified="2013-05-01" version="1" fragment="single">LFFTLPLAFTALVISTPTKLDNRFYLGKVQDTLEARQALVTQAPSIPPPPPASQPVVCSCPKILGRCIVDASCVCCN</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
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        <property type="evidence" value="ECO:0007669"/>
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            <begin position="219"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60356.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="231" mass="26510" checksum="3FFF3ACD5B9925CC" modified="2013-05-01" version="1">MDEYEEAVLFTFSLLESRLDRLEYVLGGPQEVAKDKPRTISDRIHKIEQSLQQLAGKTALLDEANSLLSKHKDVLKPQVDHEDDDYEDEDNAPLDTAYKTALVVERATSFATTASQLKALEDQHIPTTDGFTKLAALRPRIAEAEERQLQQALKMSELRRRNGLINQRYRQVMVLGAGRCWVDYNERLTQALRALVREEYRRRPEDEKDNGDEGAHEEEGPEEEDAEDDEL</sequence>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVK3</accession>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD66340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19133642"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_188716"/>
    <dbReference type="eggNOG" id="KOG1879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002668_1_0_1"/>
    <dbReference type="OMA" id="RQTKTRF"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_transf_24"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025399" evidence="10">
        <location>
            <begin position="27"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="41"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="273"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="410"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="666"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1202"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1488"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1489"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD66340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1508" mass="168874" checksum="B0817E03302847AC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVY0</accession>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_238227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705158.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19134928"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_238227"/>
    <dbReference type="HOGENOM" id="CLU_2621874_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025386" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8745" checksum="880753CFCCAB01B8" modified="2013-05-01" version="1">MVKRARIKALAVACVCSLCGEGATRRWANGGGQIRWQVPYSTYIVSTYVLEYVCIRRAATLLECLSWVVRRRGPKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWF6</accession>
    <name>M2SWF6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_122800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702696.1">
        <property type="nucleotide sequence ID" value="XM_007704506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWF6"/>
    <dbReference type="GeneID" id="19130535"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_122800"/>
    <dbReference type="eggNOG" id="ENOG502SZ93">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196215_1_0_1"/>
    <dbReference type="OMA" id="CFYHAYT"/>
    <dbReference type="OrthoDB" id="3699805at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="56" mass="6342" checksum="D1A425E163F5831B" modified="2013-05-01" version="1">MCFYHAYTHQCGHTQMVFQQLCPKGQMVQQKCNRGHDGVILATVKVETSCEVCPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX78</accession>
    <name>M2SX78_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">COCSADRAFT_96501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702782.1">
        <property type="nucleotide sequence ID" value="XM_007704592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX78"/>
    <dbReference type="STRING" id="665912.M2SX78"/>
    <dbReference type="GeneID" id="19141680"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_96501"/>
    <dbReference type="eggNOG" id="ENOG502QXG3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792651_0_0_1"/>
    <dbReference type="OMA" id="TSAFHLC"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD61432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="401" mass="43156" checksum="45794F76E9301341" modified="2013-05-01" version="1">MSDHSAKRQRLDSIGRFSPASPPFDVAAKASGQTTKTLPHPRTPTSPPYSSMNSQSNGGFSTTNTTTSSDRSPQSSVLMAHSLSQSAASASSLHPFPTPASTAGFLSSANVDSDGDATMEESADDDTLRSRCHRLSNHNRQAQSPYTPDGRLKAAQGISGSQLFKLNTDRIEKSRPHASQNLIRLYRLEPLASSVARNDPVTGEKINKLRKSYEGHIKQMQIAGKPKATKMDGVFRDLLMLPEEIWLPNHVQNREADKTALMPDGTGLTPDFSQLLDGAFAGMGPGPLPNADAAKYKAYLGTDDTVKPKAQDAPPQRTTPYTSSAPTPNNHINRGLVRPERSGSKRAYTDAAFQGYGEGFGDDYADSTGGEDTPGGSLANKRRKLQFERTSHSVEVGGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXL1</accession>
    <name>M2SXL1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_344402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702866.1">
        <property type="nucleotide sequence ID" value="XM_007704676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXL1"/>
    <dbReference type="STRING" id="665912.M2SXL1"/>
    <dbReference type="GeneID" id="19137652"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_344402"/>
    <dbReference type="eggNOG" id="KOG3401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_0_1_1"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="135" mass="15221" checksum="5CDDC90E19DF0567" modified="2013-05-01" version="1">MTKVQSMVASSRRKSRKAHFSAPSSVRRVIMSAPLSKELREKHGVRSIPIRKDDEITVVRGSNKGREGKVSSVYRLKYCIHVNGIVREKSNGQSVPTPIAPSKVVITKLKLDKDRESILERKSAGREEKKKQREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY37</accession>
    <name>M2SY37_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_202097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702992.1">
        <property type="nucleotide sequence ID" value="XM_007704802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY37"/>
    <dbReference type="STRING" id="665912.M2SY37"/>
    <dbReference type="GeneID" id="19134213"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_202097"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_5_0_1"/>
    <dbReference type="OMA" id="AMATNIQ"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="340" mass="35960" checksum="EF0EB4BD082CD737" modified="2013-05-01" version="1">MDSSEKLHVGWIGLGSMGLAMATNIQKHIQQHQDAYPQLKYWNRTISRGKPLEELGATACATVADLVQTCNVIFISVSDDTAITTLTTTIQNSGPLSQKIIIDTTTVHPSTTTIISTSFTQKDASYISAPVFGATPVAIAGQLLIAVAGPPQAITRVTPLLKGVLARRVLHVGDEASQAMLLKTTSNFITAGLMTLLSEAHVLAETSGLAASTLESLIEENFGAYALGVSRRLTSGSYLPAVGQAPASGLELGIKDVGHGVVVARGKGVELRIGEMYLEAAEEAKGYAEGRGRRADSSAVYGVLRQRAGLGFESEVVRRRDGHVIYPNIVDASVKPQPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYD8</accession>
    <name>M2SYD8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_95702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702218.1">
        <property type="nucleotide sequence ID" value="XM_007704028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYD8"/>
    <dbReference type="STRING" id="665912.M2SYD8"/>
    <dbReference type="GeneID" id="19141633"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95702"/>
    <dbReference type="eggNOG" id="ENOG502S8P5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_0_0_1"/>
    <dbReference type="OMA" id="ATHASCS"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="140" mass="15465" checksum="C6B60D0470607A9D" modified="2013-05-01" version="1">MNAFRCLRVASTSSCALLRLRTSGTAAATQRLSTPSQTRQISLLSPRRPLVPATYSSPSTLAPSGTSSSLANLETLDLVGRISAHPALGSTQIRCGPRDTYNPSHLVRKRRHGFLSRLRTKKGRKMIMRRLKKGRWNISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZZ1</accession>
    <name>M2SZZ1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701619.1">
        <property type="nucleotide sequence ID" value="XM_007703429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZZ1"/>
    <dbReference type="GeneID" id="19139253"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38427"/>
    <dbReference type="eggNOG" id="ENOG502S4HH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142422_0_0_1"/>
    <dbReference type="OMA" id="MRFTYIA"/>
    <dbReference type="OrthoDB" id="3695673at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026273" evidence="1">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="153" mass="14237" checksum="5738280EF85E75C8" modified="2013-05-01" version="1">MRFTYIATALFAAGAANAQVDSVIASLTSAVGNLPSDVASNVESLASRVTSVGGSVPSAASSIGSRITSGAAGLPSDAASAASSIRSSANAAASSIRSEAESALSSATASLGSAASSGASSTGSPQETGAANQNALPAMGAAAAGIFALAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T001</accession>
    <name>M2T001_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_94346</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701750.1">
        <property type="nucleotide sequence ID" value="XM_007703560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T001"/>
    <dbReference type="STRING" id="665912.M2T001"/>
    <dbReference type="GeneID" id="19141554"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_94346"/>
    <dbReference type="eggNOG" id="KOG3364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104368_2_0_1"/>
    <dbReference type="OMA" id="QFNYAWG"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD62357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="154" mass="17082" checksum="6710CDD0C2CAEF3B" modified="2013-05-01" version="1">MPPSLPYAADVESPLKPEELQVLRAQYEKEGEYVGLQTKFNYAWGLIKSTSRPDQQEGVRLLSEIFRNSRERRRECLYYLALGNYKLGNYAEARRYNELLLELEPANLQAGSLKSLIDEKVAKEGLVGAAIVGGIVVAAGVVGSLLLRGGPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0N9</accession>
    <name>M2T0N9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_79429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Hamelin R.C."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class III subfamily.</text>
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    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
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        <property type="protein sequence ID" value="EMD68255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T148"/>
    <dbReference type="STRING" id="665912.M2T148"/>
    <dbReference type="GeneID" id="19137092"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33205"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_0_1_1"/>
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    <dbReference type="OrthoDB" id="26569at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="133"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="84"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD68255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="900" mass="101069" checksum="70065409D417AD68" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1T6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">COCSADRAFT_38036</name>
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    <organism evidence="2 3">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="102" mass="11076" checksum="1E42AAC094D60CEC" modified="2013-05-01" version="1">MLTTLPIPHTLPVPAIPMQWLSITGTVRSCPRSSRRPPPTATCRTHPRAAETNASSSPAVSNTLDPSTPRPLFSSLPAILFPIPRFPLALMTYPVSQLRKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1X2</accession>
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            <fullName evidence="4">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">COCSADRAFT_200645</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19134153"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_200645"/>
    <dbReference type="eggNOG" id="ENOG502S9NN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084512_0_0_1"/>
    <dbReference type="OMA" id="KNPCGAQ"/>
    <dbReference type="OrthoDB" id="2439692at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF2">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026179" description="DUF7707 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="4">
        <location>
            <begin position="28"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD63022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="213" mass="22327" checksum="5A3679547DBFF30F" modified="2013-05-01" version="1">MRSVFALGIAALTGFTAAQTTPQMNYPYTIDPDTVPQSTRDYWCSQNTAQCPLICLQQPGVNSMSTESNDCDSDNLTYNCVCDNGISPNITEYSQTLPFFICQQWGNNCVDNCGNDSTCQSACRQDHPCGAQEPYRGNTSLPTTMASTAKPSGTASNTIPVTGFGGAEPTGSSGSNSGNNNNNTGAGSLFMPNAGLGLAALFGSVFFGFAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T322</accession>
    <name>M2T322_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_143777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700667.1">
        <property type="nucleotide sequence ID" value="XM_007702477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T322"/>
    <dbReference type="STRING" id="665912.M2T322"/>
    <dbReference type="GeneID" id="19131294"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_143777"/>
    <dbReference type="eggNOG" id="KOG3839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041093_1_1_1"/>
    <dbReference type="OMA" id="GCTADIR"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026039" description="L-type lectin-like domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="35"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD63596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="322" mass="36228" checksum="744A6DB8C2BF5513" modified="2013-05-01" version="1">MLLAKPWTSLCLMAGSLTGAWARSGGLTEDPDIKAISLRTHTLEPPYLDSDMQSRWWDFGGDTIIRTDKYIRLASDKPSRDGWIFSRVPLTATNWEVMFEFKIHGQGNLYGDGFAMWLTKQRAQPGNVFGHTDKFEGLGIFFDTYKNNRPGTVFPYIMAMSGDGNTAYDKDNDGKANELAGCSARGIRNAQIATKARLTYFQEQFLRLEIQYKAEDEWTMCFEIPNFKVPPVAYLGFSAETGELSDNHDIAWVRSTNLYKKSPGAMPSTGSTGGKTASSMSRERPSEGSWTWTFVKFVLFGMALTGAYVGFTVYRARQRDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3D8</accession>
    <name>M2T3D8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_171995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700769.1">
        <property type="nucleotide sequence ID" value="XM_007702579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3D8"/>
    <dbReference type="STRING" id="665912.M2T3D8"/>
    <dbReference type="GeneID" id="19132772"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_171995"/>
    <dbReference type="eggNOG" id="ENOG502S3W3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086393_1_0_1"/>
    <dbReference type="OMA" id="YIEMWDY"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD63741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="160" mass="18317" checksum="71192401CF40402A" modified="2013-05-01" version="1">MDMSYIGTTANTSTTNDYGIDVRRYSDSSTDSDIPEMVRFEEHKGAITNYIEMWDYVGGVMFRGFVVEREEERSMFVFFDEAVIGADLKAGLMALLELCEIDYFSCSRLVLCIDRHSDQVARNNLTKDLGWIGFGLTTLDDFSQGEKLTSDKWLFMDMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3T6</accession>
    <name>M2T3T6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin-11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_144458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700891.1">
        <property type="nucleotide sequence ID" value="XM_007702701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3T6"/>
    <dbReference type="STRING" id="665912.M2T3T6"/>
    <dbReference type="GeneID" id="19131312"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_144458"/>
    <dbReference type="eggNOG" id="ENOG502S1P2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052213_1_0_1"/>
    <dbReference type="OMA" id="DWIRPLA"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD63916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35907" checksum="AEF63C7B919AEADE" modified="2013-05-01" version="1">MSDEEKKPVDAPDTTDTTDTTDTPEAKEAVDKIAEAAPPARPSSISKTGLLAGVKKADETILRLNKLLASPGGLSAFLSTFNYTLYILAYAQTKSPAVSAFATKLLSLIRPACDDTKIPATTLVDNGTVPPIAALAVLISKTRTTLRLTGTLPLYAWLRSLASGPKPGTDVVLHRIATLQAMSYFAYQLLENISLLADSGVVSPRVISALNRGNPKTARLYLYAYRCWLGGVSCDFLRLMREWQIEGRRRLTRQQMVAEGKAIAEYQDEEDKRFDKRWWTDFVIASAWFPMALHFSSASGGIPGWNLGIMGACGLIAGSTRMKALWASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T485</accession>
    <name>M2T485_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_144309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700837.1">
        <property type="nucleotide sequence ID" value="XM_007702647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T485"/>
    <dbReference type="STRING" id="665912.M2T485"/>
    <dbReference type="GeneID" id="19131306"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_144309"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028824_0_0_1"/>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD63837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="46652" checksum="B92B86E832020AF8" modified="2013-05-01" version="1">MWDGLFMLLALSTVMGIASFLAGILPLSFNLSTRQLRIMTLLGTGVLVGTSLIVIIPEGIETMYSAGMKTHAHSRSVRSAAQPAILSARSLQGDLHAPEFPAWKRADQIEVKNLGEAVELQMNKAKYARQTEKPTEDPHPQKGGDDDSTEGHKEGHTRVHAPEDEEKPHGHAEASHDDGSSPHAYIGVALILGYILMFLVEHLPEALASGQPEYQPMHISLSNLARGPHNSSSLSVNGMGMQSAAVTPLATPGLPPPPTKKTPAATIGLVVHACADGIALGASSTAESTSLSLVIFFAIMLHKAPAAFGLTSVLLKQGLSKRKARTHLAFFSLAAPVGALATWTIVHMFGRNHLGGDEGLTWATGWVLCFSGGTFLYVAMHSMADATASQHAHEDPTANGYMEAYSGSNRMSKTDVSIVMLGMMLPLITQIGHAHSHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2T491</accession>
    <name>M2T491_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_142175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699969.1">
        <property type="nucleotide sequence ID" value="XM_007701779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T491"/>
    <dbReference type="STRING" id="665912.M2T491"/>
    <dbReference type="GeneID" id="19131234"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_142175"/>
    <dbReference type="eggNOG" id="ENOG502R8TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104718_0_0_1"/>
    <dbReference type="OMA" id="AATIFHH"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="163" mass="18010" checksum="FD247478B8082FF9" modified="2013-05-01" version="1">MPSMNSTVFHAYAYGTAFWYGLRGLCRVYDPIMVIGWFRPPSQLNLAPNDLETYNVRNDGWCLITLALVLISLTNAVPFTSESVKKFSSVPYAKAIVAATIFHHVATGIGAYQHYKLPSHYNTSMSIGVWGNIWLSLTGLFTLALLQSDAGDMSVEQAAQKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4U4</accession>
    <name>M2T4U4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_155635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694770.1">
        <property type="nucleotide sequence ID" value="XM_007696580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4U4"/>
    <dbReference type="GeneID" id="19131710"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155635"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OMA" id="EMERWFW"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59655" checksum="D620A3C80EF00789" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M2T511</accession>
    <name>M2T511_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Cytochrome P450</fullName>
                <ecNumber evidence="15">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="15">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_76344</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
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    <dbReference type="EC" id="1.6.2.4" evidence="15"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYP120A1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
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    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
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        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
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        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
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        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
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    </dbReference>
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        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 15" id="KW-0288">FMN</keyword>
    <keyword evidence="4 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0521">NADP</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="504"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="678"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD69510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120699" checksum="D46F5ABB457864A6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5D1</accession>
    <name>M2T5D1_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_60407</name>
        <name evidence="4" type="ORF">COCSADRAFT_64798</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr</strain>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="682" mass="74890" checksum="8398ABFC7E44BB2E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5K5</accession>
    <name>M2T5K5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_26657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699730.1">
        <property type="nucleotide sequence ID" value="XM_007701540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5K5"/>
    <dbReference type="GeneID" id="19135529"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_26657"/>
    <dbReference type="eggNOG" id="ENOG502T0EV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2133299_0_0_1"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="113" mass="12463" checksum="F5A4270077622277" modified="2013-05-01" version="1">MASPLIEFVKISFPAARATPDFRGSIERDFRVFDEKCVAVARGNGGVAFGWGVDEEEQEGVEGGMAVGFFVLRGWEGMEYFEQLVGTSEFKGAIEGLKGWGAPMNMWFVQRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5X0</accession>
    <name>M2T5X0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_357390</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700206.1">
        <property type="nucleotide sequence ID" value="XM_007702016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5X0"/>
    <dbReference type="STRING" id="665912.M2T5X0"/>
    <dbReference type="GeneID" id="19138495"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357390"/>
    <dbReference type="eggNOG" id="KOG0136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="OMA" id="WNMYNVL"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="283"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="488"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="686" mass="76289" checksum="CAE2484CFB706EBA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">COCSADRAFT_356003</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699382.1">
        <property type="nucleotide sequence ID" value="XM_007701192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T768"/>
    <dbReference type="GeneID" id="19138407"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_356003"/>
    <dbReference type="HOGENOM" id="CLU_818856_0_0_1"/>
    <dbReference type="OrthoDB" id="3690508at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="395" mass="42146" checksum="47A2D49959D54941" modified="2013-05-01" version="1">MRPRLGAACKHACVVWYVACDTMQPDCQPASQPASQPGWAGRSSAQTPRVLQTPHSPHPYPSTYYLLTRMHAFAYLLGTLAAFPVPSLWGSIESSLPLSRPVSGGFTLASREPTDAFAPRCHSTILISGQPQGPALARAQSQIHRREPIQWPIYGRPKENFSRRLIVRIISAVVQLGMHPGLEPHSPAGLAASTSAALPRQIAASEHGRPARREAKAHSAHTCAYGRPNANLLTKLGIVASLPITNQPDPAPPSLASSKATVTHDKGELANTYTLDTNRPRDKNECHQAFPPLADQLGVSTGPVQHKASSELLGPQIQVANPSFVPELSAGSPQCPTADLPDEEMLAVKAAADESRTLVGIMALATPFAPAEEILPQVIAPLTAVSSTSWIVERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">COCSADRAFT_141211</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
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    <dbReference type="STRING" id="665912.M2T7F6"/>
    <dbReference type="GeneID" id="19131191"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_141211"/>
    <dbReference type="eggNOG" id="ENOG502SDJU">
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    </dbReference>
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    <dbReference type="OMA" id="CGECTTN"/>
    <dbReference type="OrthoDB" id="2398441at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="E3_SLX5/Rfp1"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
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            <end position="232"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="504" mass="56355" checksum="166C5DDB445BABA9" modified="2013-05-01" version="1">MEGEELPFGYTHRREKRSHEQMDDDDDEGSASPAWRYNPFPDIHPHQTQPRYPSGLPLIEHHLPRPAYYDHAQDAAHNNYEDPHARRHHLQQPRRAPAFESALRAARPPIERASSSTATQPRPAGLHLPRMENMASSASVRFPGDGFDYRRPAGSSREPDVGSVDLTGEEEDVGPDLSRVDQEDDNGDHDNHDDDDDIIIDLTADDSGYGASQDGNSGRQRHDHVDQQDPNRARANGGPRLPRGMDIIIDLDNGEEEWRMATPAPEPSSPDIEFISSRTINPRRLPPPNLAGNNSDGDEVEFLRENALPEAEIRRRRTRELDNVLDLFGTLNGRFTHLRAQVDRFNAQINRTAGRFHEPVAPHRNSSRGHTHIRLGFIAPVMDFEGTGFNYGQAAREAPAPPPTYEAPPQAPEGFTRSPEEEGALICPNCEEELCVGSDEIKRQVWIVKGCGHVYCGECTTNRAAKRTAKGKERPVSTNPFKTCVVEGCDKNVSNKKSMIQVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M2T836</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_35462</name>
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    <organism evidence="1 2">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007700129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T836"/>
    <dbReference type="GeneID" id="19138311"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35462"/>
    <dbReference type="HOGENOM" id="CLU_1682068_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="157" mass="17449" checksum="FEEE784990190F8F" modified="2013-05-01" version="1" fragment="single">MLHSCHILHPYRTVPSPRANPGSSNSDTARDYTCCIRQNKRHPSFLTERSFTPQDEPRFFSGSGTARDYTCCIGKRRGRRVGKRFSCVDWGMRCFYAEASSRGGILYAAKWTHLLNDIGPKFISATYLTSSMHWKDVAVGSSGEALGCVDVGLGFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8C6</accession>
    <name>M2T8C6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_35537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698336.1">
        <property type="nucleotide sequence ID" value="XM_007700146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8C6"/>
    <dbReference type="GeneID" id="19138360"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35537"/>
    <dbReference type="HOGENOM" id="CLU_1626875_0_0_1"/>
    <dbReference type="OMA" id="CAKQKSN"/>
    <dbReference type="OrthoDB" id="3694694at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="162" mass="17869" checksum="84EBD9070C0C2827" modified="2013-05-01" version="1">MAMTYFKRWSTLPPSPTPSLNDSLSSSSSSTISTPPRSPTPSSTTRLFSALKSSTTFPLSIRKVSSPWHSSTTVQPHIPYLDNASHVGSTTSLCTADPTAIAGCAKQKSNEKRVLAWRRETRTLQIEYESLPLRRRREALERVNEGRVRLGLPRRSLGGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAV5</accession>
    <name>M2TAV5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-ribosomal peptide synthetase NPS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NPS1</name>
        <name evidence="5" type="ORF">COCSADRAFT_115356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD66017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699013.1">
        <property type="nucleotide sequence ID" value="XM_007700823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAV5"/>
    <dbReference type="STRING" id="665912.M2TAV5"/>
    <dbReference type="GeneID" id="19130279"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_115356"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_1"/>
    <dbReference type="OMA" id="FMMGTAE"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="543"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD66017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="636" mass="70243" checksum="2E246A1B831C999A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBS9</accession>
    <name>M2TBS9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_34883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0157">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD66317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59198" checksum="B63EF99DB5CC1759" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCW6</accession>
    <name>M2TCW6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_187917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696832.1">
        <property type="nucleotide sequence ID" value="XM_007698642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCW6"/>
    <dbReference type="GeneID" id="19133607"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_187917"/>
    <dbReference type="eggNOG" id="ENOG502QVMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041459_0_0_1"/>
    <dbReference type="OMA" id="IWEAVSA"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59733" checksum="64EFD499C3A70767" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDG5</accession>
    <name>M2TDG5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1682 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_138829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698185.1">
        <property type="nucleotide sequence ID" value="XM_007699995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDG5"/>
    <dbReference type="STRING" id="665912.M2TDG5"/>
    <dbReference type="GeneID" id="19131100"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_138829"/>
    <dbReference type="eggNOG" id="KOG2357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042570_0_0_1"/>
    <dbReference type="OMA" id="FDGFVWA"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD66792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49009" checksum="51F525C3800ADFF3" modified="2013-05-01" version="1">MADFVKGLFGGQKPMPAPAAGDDDFADYASAPDPKPAAISPVTTLTGAAQAAPTSFGANRPYTAWYRVWERTSIDDFQLEMYILPFLFLLVAFHLWGTNRNRSKAKTWIKAHAPVLTQEFAQVGYTRPQSEQSVTDVDSLLKEKAADEFQTYATGRQNVAFVDFRLSFSKGYNPFMWLGDHTLPLFFESFPPPVERVGATAYVFDGRETKIAPSYGQGDAKKVSNSTFDGFVFAVVHKDMMKRMREDRYDLSLTTTRDHAKLPVWTTVMSESAEVTDMLLTPELIKAIEQAGDNFEAIIVTDQPIDAPKTLDETKPRKRIHLSLKYSSDYTNTMPLFQYFLRLPDFLATSAHFRPEALRRIKQTRDEQIAKIRKAEDEEKAEERKLALDKLKKEQRDAKLGRLSAEEQRKFLEKEREKNARKGMKRSTVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2TE49</accession>
    <name>M2TE49_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_110396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696786.1">
        <property type="nucleotide sequence ID" value="XM_007698596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TE49"/>
    <dbReference type="GeneID" id="19130123"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_110396"/>
    <dbReference type="eggNOG" id="ENOG502SI2K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022883_1_0_1"/>
    <dbReference type="OMA" id="DCIATPV"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="444" mass="50735" checksum="A7F682F9FB12F6FE" modified="2013-05-01" version="1">MDILWSCTSTIFLCCWSMLCLNVPGRYDTNGTKLRRKAMIFVLTLFTPEVVTVAASGQYFAARQSVKDFKAANIGEWSPQHAFFAEMGGFVLQTRDWVPFPISAKQLLWLIQHEYVAIPPALTGRILDRNKADNLTRFLMVIQTVWFLANFFTRIAQNLSPTALELTTVAFIYASLPTMFFWWHKPADVSVPEILTTNASMAEILLTGGDAAREPYGHTPLDFLDRREWFWMIYWAHFRAAVRGLGVPAGTRVRPIDRFSNFSSAETPTWFFNLGAIYYFGFCAIFVAGWHLSLPSQREQLLWRVASLTALGTLVGCAVVTEMTFRIWPYLRNSLAARKEPDIAETDHSPSMIPFGRRKDKSRTTEGLRPRPRTIWDWIRNNTTSQNPRFSLPVLTAILMQLLCFTHLLARLYIVVGDFAAMRSLPSSCYKTTVWQQFIPHLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFG6</accession>
    <name>M2TFG6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_156456</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695722.1">
        <property type="nucleotide sequence ID" value="XM_007697532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFG6"/>
    <dbReference type="STRING" id="665912.M2TFG6"/>
    <dbReference type="GeneID" id="19131761"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156456"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_1"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="39"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="303"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD67991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="551" mass="60565" checksum="33507E2C3B5E2D86" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFJ6</accession>
    <name>M2TFJ6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_83298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697153.1">
        <property type="nucleotide sequence ID" value="XM_007698963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFJ6"/>
    <dbReference type="GeneID" id="19140949"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_83298"/>
    <dbReference type="eggNOG" id="ENOG502RIBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871957_0_0_1"/>
    <dbReference type="OMA" id="NAAAFKM"/>
    <dbReference type="OrthoDB" id="3793088at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="316" mass="35489" checksum="80E2BE7A058A47DA" modified="2013-05-01" version="1">MAVGTYVASKNLAEIREKLGEPFANSLEYLPLDKVITKTQKHEEDYISFMLLFGHVRNQCEDGNQEVWVMLSPPTKEGGQTRIEFNSYDSATGASEWHNNHNISTSAENAAAFKMPKKASLGKHTALARYYFLQKLAADEAKNNGISELKFPIPVKKGLLECLKTACSEFEGEAKAALARSVRQLSVTLPESQDSDDTLAFEDSKETFKEQVQRAWAVQTPHNNIAQALAILNDKEKNIKSHIANLDDHLIALTEQRVDLEQRCKHVEAERLVAEKEIASIKAQRDDLFKGMSPEAVFELGRSSERTNPTKRRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIT9</accession>
    <name>M2TIT9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_109323</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696167.1">
        <property type="nucleotide sequence ID" value="XM_007697977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIT9"/>
    <dbReference type="STRING" id="665912.M2TIT9"/>
    <dbReference type="GeneID" id="19130086"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_109323"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_1_1"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="71"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD68612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="462" mass="50692" checksum="CE609C9736A6BAF7" modified="2013-05-01" version="1">MSGQQCLRRLPAAMRSVRALRASPRCTPTARSYSALTKANSSGLLGQASRRPGQLSSQRLCALEQIRTYADTIVKVPEMAESITEGTLKQWSKQVGDFVEQDEEIATIETDKIDVAVNAPEAGTIKEFLVNEEDTVTVGQEIVKLEPGAAPEGGKKEASQEPKEPASQDQETSSQPEGQQEQSQPEAPKEESKPAPPKQQEQPKQESKPEPKKDSKPKEEPKPATPGSREERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSSIMEFRKLYKDEILKNKGVKLGFMSAFSRACILAARDVPAVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRNAESMDMVGIEKAIADLGKKARDNKLTIEDMAGGTFTISNGGVFGSLMGTPIINLPQTAVLGLHAIKEKPVAINGKVEIRPMMYLALTYDHRLLDGREAVTFLVKVKEYIEDPRKMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK92</accession>
    <name>M2TK92_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">COCSADRAFT_206305</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694532.1">
        <property type="nucleotide sequence ID" value="XM_007696342.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2TK92"/>
    <dbReference type="GeneID" id="19134325"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_206305"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_0_0_1"/>
    <dbReference type="OMA" id="QALRCGR"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1118"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1149"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1200"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1241"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1266"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1308"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="1086"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="257"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1357"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1488"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="1573" mass="176988" checksum="DD274974213A64F7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLK3</accession>
    <name>M2TLK3_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Shikimate dehydrogenase substrate binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_107251</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007696990.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="AIYVMRR"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="Shikimate_DH-bd_N"/>
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        <property type="entry name" value="Shikimate_DH_fam"/>
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        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Shikimate_dh_N"/>
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        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD70031.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="313" mass="34618" checksum="20D3A146AECC6413" modified="2013-05-01" version="1">MSTESTETRIPDVSQTERHGYLFGHPIAHSMSPLLHKTVYDGLGLNWAQYPLESKDMSLFLQLIKHPQFYGASVTMPHKVAILPHLDGLTEEGRDVGAVNTLFIQEDPSTGKRLYMGTNTDVIGIRDAFAYNIDASKYENRPALVIGGGGAARSAVYALRKWMKASAIYLVNRDAAEVSAVISECNARGYGSSLVHVSTLSQAQSLPGVGAIVSCVPNFSPVTLQEIEARDILNCFLQKKHKGALLEMCYHPTTWTEIAEIGKNEGWQIVLGTEALIYQGLEQDRYWTAREVRELPVEKVQEAIARKLSEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLL5</accession>
    <name>M2TLL5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_211401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
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        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">COCSADRAFT_32763</name>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD70136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696183.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018310_0_1_1"/>
    <dbReference type="OMA" id="MPYERSK"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
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        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0116">cAMP-binding</keyword>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="392"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="523"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD70136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="649" mass="70927" checksum="159B492F78CC6C9C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2QTR6</accession>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_129049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705663.1">
        <property type="nucleotide sequence ID" value="XM_007707473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QTR6"/>
    <dbReference type="STRING" id="665912.M2QTR6"/>
    <dbReference type="GeneID" id="19130733"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_129049"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_2_2_1"/>
    <dbReference type="OMA" id="CWALRNQ"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
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    </dbReference>
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        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="181"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="382"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD58559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="468" mass="51816" checksum="E366D4A20FAD4E33" modified="2013-05-01" version="1">MSEPDLHRAISMKPHPFHTHPDRIERTSSPHIHLTPVGSSSHGDGATRGKTGASSTAIDRSPSTSTDHHARHVPASSAGAADVESQSPPAYTPDTDPYRLAAAIKPESELALIRANTSRKRDGCGPISLNAKSRSAKKLEEFYSAQNENIERLLKPVDDHRRAAKEEGDANHLKYKIAVIGSFAANIILAVLQLYAAISSQSLSLFTTMADSLFDPLSNLTLILCNRAVARVDARKFPSGKARIETAGNLCFCALMITVSVVIIVESIRTVAEHSGPETNDFYLPSVIAVAIAFATKFSLFLYCWALRNKYSQVRILWEDHRNDLFINGFGVLTSVGGSKLKWWIDPMGAMILSVLIIFLWSRTAYSEFQLLIGVTADTSMLQHITYISMTHSPNILQIDTVRAYHSGPRLIVEVDIVMNPDDTLRATHDVAEELQIKLESLPDVERAYVHVDYETDHRPEHFLKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2QTZ9</accession>
    <name>M2QTZ9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_348849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705697.1">
        <property type="nucleotide sequence ID" value="XM_007707507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QTZ9"/>
    <dbReference type="GeneID" id="19137919"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_348849"/>
    <dbReference type="eggNOG" id="ENOG502S2ST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043165_0_0_1"/>
    <dbReference type="OMA" id="HEHQNPL"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023440" description="Peptidase metallopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43878" checksum="829E8B50CE18DC4A" modified="2013-05-01" version="1">MRISTRMLVIVLLAHAESALGGSRHWEAKAPNKQTNPSPDYPATDVLNATSSLLKRAISIDNRPGNNALPRIWPNKKIRYCFVEPDHVIRGLWDLARNAWATLEANGFSYEEVTNREQCEAEKATILHIHYNNHGKLATTLGIPSIDEKWNKENPDRKVEGPFIHLSDLQGIGQDNIAANVAHELGHAWGLVHEHQNPFFWELTPEDARNGWAFPQTKGMVSKFKTSDFKCDRMKDYKEAHDAVRAKIAEAIADGKELLRGELEVDLERLCISRGAAFKHRFLASEWLPYSNTGGFVMDEEFDPLSLMLYPSGAGGIGSGNNRAQVMVYKDGAPIPNRLAPTNRDIARLLALYSDTGSSTPAEPHTSKSSKLKNAFRKARIFLNRAGDTVSGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2QYA0</accession>
    <name>M2QYA0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_40461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704088.1">
        <property type="nucleotide sequence ID" value="XM_007705898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QYA0"/>
    <dbReference type="GeneID" id="19139743"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40461"/>
    <dbReference type="HOGENOM" id="CLU_116367_0_0_1"/>
    <dbReference type="OMA" id="FEAFVEW"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="148" mass="16392" checksum="CA0F984A7258E3E0" modified="2013-05-01" version="1">MISTPPTRIPVHEQKLAACSPLLRRLLSRAPRPNIRGGRILKFENVEVRTFEAFVEWLYGNSGTRMVRSNTSSVTNTTTTACGGDNDDDGGGEEGVVSEALRAFAREYEVAFLVEEEEQEEQESGCAGLESRRAWRDRGGACWIEGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2QYQ4</accession>
    <name>M2QYQ4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_164278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ND90Pr</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704351.1">
        <property type="nucleotide sequence ID" value="XM_007706161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QYQ4"/>
    <dbReference type="GeneID" id="19132301"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164278"/>
    <dbReference type="eggNOG" id="ENOG502S6DV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044597_0_0_1"/>
    <dbReference type="OMA" id="MLLFDCE"/>
    <dbReference type="OrthoDB" id="5358702at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD60144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="336" mass="38568" checksum="0F6F50E09BE9EE56" modified="2013-05-01" version="1">MDSEVSERSQLQKLAYTSLTEYFQEHDNEVIEIAILPPSVQPPDGVLIQEGSSLGISKKALILAYMEARGLFFGKRQSNDPSTINQTIQATEIILLFDPEHITAANYRKRVLAQLQDEHGLHAGNIFHKALLRELYFLDSVLTSPLHRQSKSPTLWYHRSRIVDSLILFGLTDTLDGQKVVFWNNELEAVCKSGEQHPRNYHAWQYARRLVQKAHGFGSDDQFAPLVKKWCCRHPSDISGWSFLLYLMPRLAPSLRQELVRDVLDYAIKFSIENESLWVFIRTALAQDMPSVDHSIVYQHLQDYVKILTNDERPQNEAHTASNALKWIDTYGQHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZZ5</accession>
    <name>M2QZZ5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_98505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703933.1">
        <property type="nucleotide sequence ID" value="XM_007705743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZZ5"/>
    <dbReference type="GeneID" id="19141796"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_98505"/>
    <dbReference type="eggNOG" id="ENOG502S0PF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094297_2_0_1"/>
    <dbReference type="OMA" id="PLTSKTM"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="194" mass="20931" checksum="5C1C08DA13EF7B4E" modified="2013-05-01" version="1">MSLSSFKNPPTYGTLLGSTLFQSFISGVVAFRVLPRSQFSQLQKNTFPIYFSLQTALPVAMLLTYPRGGATSLLPSFLQPASATNPPPSFSFFAPATPAASTNKLAAWLHATMFVTALANLVYIGPKTTEIMGIRKHQETRDGKKSYDNGPHSKEMQALNKQFAILHGVSTVVNLIGLGAMIWYGAVLADGMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2R089</accession>
    <name>M2R089_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_193361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R089"/>
    <dbReference type="GeneID" id="19133848"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193361"/>
    <dbReference type="eggNOG" id="ENOG502S84H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119611_0_0_1"/>
    <dbReference type="OMA" id="PADIWEP"/>
    <dbReference type="OrthoDB" id="3599804at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="190" mass="20407" checksum="446AC843711EDD5F" modified="2013-05-01" version="1">MAAHQEDSITKPPVLADPSEAKAPSNASTTEVMKSFEGFLSFVLSLSIFGASTFAVIVSEIANPSELGANPRFTRETVRTLLGISWLLFIVALYLVAVSMSLLAFQREHAKPLSDGIGKHTWERLGLVASSFIQLLVIAAFLFLSLVLVAYTPAVGWVAVAFTSIAAASAFVLLAIQWIELSRHKPGTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2R2V4</accession>
    <name>M2R2V4_COCSN</name>
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        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_232609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD61544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R2V4"/>
    <dbReference type="STRING" id="665912.M2R2V4"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_232609"/>
    <dbReference type="eggNOG" id="ENOG502S752">
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    </dbReference>
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    <dbReference type="OMA" id="KHNTHLC"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000011">
        <property type="entry name" value="37S ribosomal protein S18, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD61544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="217" mass="24225" checksum="52D2F0AE2D5DE885" modified="2013-05-01" version="1">MAHNTALRTFRSLTNTIATSCRHAQSLRPFTHSTRALNAAPTDRNKPDQSMDSLLSNVSQNFYQAGQDQFSTLIPNADGFPRVGNLVQREWEEDDKHKLHVYATKHNTHLCLTRPNRDPLISVSCGNIGFRKAGRGSYDAAYQLAAFLMNRIQDKGLLPQIKKLELVYRGFGPGREAVTKAILGAEGKKIRPLIVKLADSTRLKFGGVRSKKPRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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    <name>M2R4A9_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_227207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702366.1">
        <property type="nucleotide sequence ID" value="XM_007704176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R4A9"/>
    <dbReference type="GeneID" id="19134699"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_227207"/>
    <dbReference type="HOGENOM" id="CLU_3129645_0_0_1"/>
    <dbReference type="OMA" id="ALLWMHP"/>
    <dbReference type="OrthoDB" id="3675695at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="56" mass="6345" checksum="7D3718DD1B2D7BBB" modified="2013-05-01" version="1">MMAWVQTPSLLDTHTVIARVHPIGKGILLFIPLALLWMHPCASASARLRQRLNQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2R5S2</accession>
    <name>M2R5S2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Trichome differentiation protein GL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_221816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701873.1">
        <property type="nucleotide sequence ID" value="XM_007703683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R5S2"/>
    <dbReference type="STRING" id="665912.M2R5S2"/>
    <dbReference type="GeneID" id="19134602"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_221816"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046302_2_1_1"/>
    <dbReference type="OMA" id="THHHSMP"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901002">
        <property type="term" value="P:positive regulation of response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902584">
        <property type="term" value="P:positive regulation of response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902806">
        <property type="term" value="P:regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000037">
        <property type="term" value="P:regulation of stomatal complex patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000355">
        <property type="entry name" value="Transcription factor MYB124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD62524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45293" checksum="A5576781CECCF594" modified="2013-05-01" version="1">MVAHRRGPWSQHEDQWLVNLVARNGPHNWVRISQEIGSRSPKQCRERYHQNLKPSLNHDPITGEEGELIEKMVAEMGKRWAEIARRLKGRSDNAVKNWWNGGQNRRKRNPERADQRPRDYMHQAQPGFHYPLPSTLPHHEEYHQMTPRHDQQRHDSHRPSVHSPHALKLPQPQRFEPYPAPRPQPLDLATYGSHAAVRARGFETPMPSPSGYSIVSADGAPSLITDTGSESRSPRGAASPLDMTLAPLVGSREERKNSSTRYLPATGFAPEDDSSSDPYRRRGSLQLPPLHRNEAQASKAAPSFREPNYERPQPPQLLTQPTPQLTHHHSMPQSAPTSVPQRPLPPFHSLAEPRLPLPHSTSASSSPASRQLPSPYVLPSMPAEARSAPVSPKDRMSLRNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8A8</accession>
    <name>M2R8A8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_172560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701398.1">
        <property type="nucleotide sequence ID" value="XM_007703208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R8A8"/>
    <dbReference type="GeneID" id="19132796"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_172560"/>
    <dbReference type="eggNOG" id="ENOG502SJWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026304_1_0_1"/>
    <dbReference type="OMA" id="ACKQHAA"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="532" mass="60697" checksum="12BC225953D33B83" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RF82</accession>
    <name>M2RF82_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_189237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698576.1">
        <property type="nucleotide sequence ID" value="XM_007700386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RF82"/>
    <dbReference type="STRING" id="665912.M2RF82"/>
    <dbReference type="GeneID" id="19133663"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_189237"/>
    <dbReference type="eggNOG" id="ENOG502QPP7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026885_0_1_1"/>
    <dbReference type="OMA" id="FKVMMQM"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="472" mass="51932" checksum="1C1A0A205B41BE1E" modified="2013-05-01" version="1">MEISNQGSATNGGSEGWSPDSWRSKPIKQVVTYEDQAAVTSALTKLSSLPPIVTPTEIARLKASLRDAALGKSFLLQGGDCAELFSYCADNPIDAKIKLLLQMSLVLIWGSNKPVIRIGRIAGQYAKPRSSPTEMLDGKEIPSFRGDILNGYDPEARRVDPERLVSAYFHSATTLNYIRAQLASGIADLHNPLDWELGHVRDEELQSKYSQIVNSISDSLRFMKTIGADTSGQLQTVDLFTSHEGLVLEYEQSLTRRLKHPAGYTPSQPSNDGKGWYNTSAHFIWIGDRTRQIDGGHVEYFRGIENPIGIKVGPSMKNDELVELLNIVNPNKEIGKITLITRYGADKVESMLGAHIEAVKSSGHVVVWQCDPMHGNTRSTPMGIKTRSFNSIFSELSSALKIHKQHESFLGGMHLELTGDAVTECTGGSEGLVDEDLSLNYTTYCDPRLNEKQALELAFLVAGHYRADGQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RFD6</accession>
    <name>M2RFD6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">15-hydroxyprostaglandin dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_169952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698613.1">
        <property type="nucleotide sequence ID" value="XM_007700423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RFD6"/>
    <dbReference type="GeneID" id="19132659"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_169952"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_0_1"/>
    <dbReference type="OMA" id="AIHFMRH"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30472" checksum="363FF0CF242A7804" modified="2013-05-01" version="1">MGIEHRVAIVTGGNSGMGMGISRGLVEKGWKVAIVDIQENSELAEELGDAASFHNCNVADYDSQAEMFQQVWDRYGRIDALCANAGIVDKSSIFIFEHRGSDKIPPKPDLLCTDVDYKGVVYGTQLAIHFFRKNKVAGGKIIATASVAGIVPHESFPEYDGAKAAVVNFVRATARILKAKENIQINAVCPGIVQTAILPQGLIDAVSAECLTPVSTVVSGFEKFLEDDTLYGRILECSADKHFFLEPPTLANGHVSRKAVTVWEPAFKMYHGETSGLSDAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2RGX7</accession>
    <name>M2RGX7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_355427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698993.1">
        <property type="nucleotide sequence ID" value="XM_007700803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RGX7"/>
    <dbReference type="GeneID" id="19138367"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355427"/>
    <dbReference type="HOGENOM" id="CLU_1578243_0_0_1"/>
    <dbReference type="OMA" id="CARRHFG"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20162" checksum="FDC50EDA77D4395C" modified="2013-05-01" version="1">MAMSLAGSTSNASPLRASGSISSLDLESEVSWGDERKRPFFPPPDEDIFPTEQAFLDSLIPVPLETVEYDKRECAFCQTRYGETPDSRSGTPEMPVRLRCAHVFGEQCARRHFGQRLIIEFNLRPIEFHPGTRGNVLISNLYRYVVEMNQYLGDFDLFKGLLDNLYDTGRLNRFFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2RI85</accession>
    <name>M2RI85_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair protein rhp54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_298475</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697946.1">
        <property type="nucleotide sequence ID" value="XM_007699756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RI85"/>
    <dbReference type="STRING" id="665912.M2RI85"/>
    <dbReference type="GeneID" id="19136124"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_298475"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_2_1"/>
    <dbReference type="OMA" id="YTEHERM"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="233"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="566"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD66459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="91319" checksum="09EA764896B3E656" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M2RIX1</accession>
    <name>M2RIX1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_35165</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697596.1">
        <property type="nucleotide sequence ID" value="XM_007699406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RIX1"/>
    <dbReference type="STRING" id="665912.M2RIX1"/>
    <dbReference type="GeneID" id="19138105"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35165"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="OMA" id="MYTGHTL"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000048">
        <property type="entry name" value="ATP-binding cassette sub-family B member 10, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002773">
        <property type="entry name" value="ABC_prm/ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="183"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="503"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="746"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD66659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="781" mass="84280" checksum="036DDFF9C57E25EF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQF6</accession>
    <name>M2RQF6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_276890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
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        <text evidence="6">Belongs to the cullin family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF26557">
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    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024244" description="Anaphase-promoting complex subunit 2" evidence="8">
        <location>
            <begin position="19"/>
            <end position="923"/>
        </location>
    </feature>
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        <location>
            <begin position="493"/>
            <end position="790"/>
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    </feature>
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        <location>
            <begin position="602"/>
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        </location>
    </feature>
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        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="633"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD68804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="5">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="6" type="ORF">COCSADRAFT_209190</name>
    </gene>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD69354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696512.1"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_209190"/>
    <dbReference type="eggNOG" id="KOG4547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038849_0_0_1"/>
    <dbReference type="OMA" id="QWSLAAH"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
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    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="187"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD69354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="425" mass="45731" checksum="8AB234892C8A3246" modified="2013-05-01" version="1">MPAALSAPRSRDRAPPAKKAKLAQPHASATARQNGLKALAGGSMAKPMAKTIGLKNSRAEKVDDATAAIQGPADAHIADADVIEISSADEQSDDDSDDAHGHSAHTSVDQDTPAPNATADEDNEDVTFGDRLRAEAPEPVQESRIISVEDTFEPNPERTVATTKDRPLAPPNANSLGTVLTQALRTNDKELLDSCLQVVDVESVYATVERLPSPLVGTLLQRLAERLHRSPGRAGMLMAWVQWSLAAHGGYLASQPQIVKQLTALNKVLKERSSGLMPLMSLKGRLDMLQAQLDLRKRNQAANDDADEALIYVEGQDDYVSDDESVEGATATTKRLRAEMDDDEDTSSDEMGLNIEMDDVSDEDSEGSDDDLIDDEAEETDDDEGEDMSDPMSDGMDDGGASESEDESKPERRSTAARAGLKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSC0</accession>
    <name>M2RSC0_COCSN</name>
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        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_77485</name>
    </gene>
    <organism evidence="9 10">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="98" mass="11275" checksum="B87DE9239E45B341" modified="2013-05-01" version="1" fragment="single">MRSFCAEISRNRMPGSELSDAQRIYILAQAEGGCSTSEIATRLSCTRRAVNKIIHQWDTEGTYTKHDRMGRPPKLTSRDHRQLLRAVKKDPKIEYRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2RTG2</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_76802</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="53" mass="6269" checksum="085CFB21372EA382" modified="2013-05-01" version="1" fragment="single">RASKVESAYLEIVTKYNYYKEKSLRYFINTASRQYTGCITIKAEYSLFISNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2RVZ8</accession>
    <name>M2RVZ8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_41112</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
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    </dbReference>
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        <location>
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</entry>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Barry K.W."/>
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                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="T-complex protein 1 subunit delta"/>
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        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD63198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="484" mass="52611" checksum="190701B485D83344" modified="2013-05-01" version="1">MDKMIQTSRGQTIITNDGATMLKQMSVMHPSAKMLVDLAHAQDIEAGDGTTSVVVIAGSLLGAAERLLAKGIHPTVISEAFQRAAQEAISILTEMAIPISLTDRQTLLKTATTSLSSKIVAQEPKLPIMAVDSVLKVIDPKTADNVDLKNIRMIKKMGGTIEDSEMIDGLVLNQPVVKSAGGPTLKEKARIGLIQFQLSPPKPDMENQIVVNDYRQMDKILKEERTYLLNMVKKIQKAKCNVLFIQKSILRDAVNDLSLHFLSKLKILVIKDIERDEIEFICKSTGCKPIADIDSFTEDKLGSADLVEEVQASGARYVKVSGVKSVVNTVSIVCRGANSLILDETERSLHDAHCAIRSLVKKKALLAGGGAPEIEIAHQLSLKARELTGTEAICWKAFADAMEVIPTTLAENAGLNSIKVVTELRHRHAQDQKYAGISIKSGGVKNDISEENVLQPLLVSTSAIELAAETVKMILRIDDIALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2S828</accession>
    <name>M2S828_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_185705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705738.1">
        <property type="nucleotide sequence ID" value="XM_007707548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S828"/>
    <dbReference type="GeneID" id="19133514"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185705"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_1_1"/>
    <dbReference type="OMA" id="PGRFINY"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024800" description="Peptidase A1 domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="97"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD58675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="406" mass="42602" checksum="1CD71DA4CC5835BF" modified="2013-05-01" version="1">MPSIVNLTAALALAGSVAANPIQLDKRGTFSINQVPHSTHLKNGPADKVKALRKYGKPVPESLLKAAENRANMVVVEATSSSGSVAASPNDQYDASYLSPVTIGTKTFHLDFDTGSSDLWVYSSLQPQSQLSGRSYYTVDPSKAKSGYTWKISYGDGSGASGKVYADKVTVGPITATSQAVEAAQSVSASFSSDANTDGLLGLAMSSINTVKPVQQTTFFDTVKSQLAKPLFSVNLKYHAAGSYDFGFIDSSKYTGAITYVNVDASQGFWGFSATGYAVGTKTTSASIDAIADTGTSLVYVDDSILRAYYAQVRGAKVDSQQGGYVFPCSSTLPDFSIVVGGVKQTIPGKYINFAPNGDGTCFGGIQSSSDLGLSIFGDVFLKSKYVIHEMGSNGPRLGFAQQSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8U5</accession>
    <name>M2S8U5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_185501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705433.1">
        <property type="nucleotide sequence ID" value="XM_007707243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8U5"/>
    <dbReference type="STRING" id="665912.M2S8U5"/>
    <dbReference type="GeneID" id="19133500"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185501"/>
    <dbReference type="eggNOG" id="ENOG502SHWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002341_7_0_1"/>
    <dbReference type="OMA" id="NNREDIH"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="311"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="490" mass="56913" checksum="2730D1E8F05F92EB" modified="2013-05-01" version="1">MNARHDQISKAHNETFEWAYTSQSTADHSCKQFKFAEWLRSGDGHYWIAGKPGSGKSTLVKFLYDNPRTLLELEDWRGQKELVIASFFFWNSGTEGQRSVEGLLQSLLYEILRKCPNLIPIVAPQRWQEWSLNHSESVPWFQREMKDAFRRIQGQGAIFAKSCFFIDGLDEYDGDQLDLISILQDLTLSPDIKLRVSSRPWNVFQDAFGQNTERRLLFKDLTKPDIERFVRDKLESSPQFKSLTAMDNRYDEIVEEIVQNADGVFLWVFLIVRSLLQGLVNCDRLSELQRRIHMLPSTLGKYFLHIISTTDETYSERAAETFEIALKAIRPLDLLIYSYLDEEDPYYGINAEIKDLSLQETMHRLQAMKRRLNVHCNGLLEITIKSSSKRDAVLEMVNEDDLQIVRLFLDIGADPKEQQQACVAWEITLQRLENLAKRDDIVHSRRDEMLKCIEQYRSIFLAYGVELTPTKPSVDLNAHEDAWGTMHSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2S947</accession>
    <name>M2S947_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_263208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705498.1">
        <property type="nucleotide sequence ID" value="XM_007707308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S947"/>
    <dbReference type="GeneID" id="19135475"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_263208"/>
    <dbReference type="HOGENOM" id="CLU_2984415_0_0_1"/>
    <dbReference type="OrthoDB" id="3688333at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="58" mass="6500" checksum="B5072B9DE55BCAF7" modified="2013-05-01" version="1" fragment="single">RYPSVTTTTNMDTASQALAQRLPKGIRDTCAAQSEHSNVPISTLIHHRLRRRSRAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2S986</accession>
    <name>M2S986_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_102597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705518.1">
        <property type="nucleotide sequence ID" value="XM_007707328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S986"/>
    <dbReference type="STRING" id="665912.M2S986"/>
    <dbReference type="GeneID" id="19129808"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102597"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295431_0_0_1"/>
    <dbReference type="OMA" id="ICIRGPC"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="511"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2S9E6</accession>
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        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">COCSADRAFT_255654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="KOG2615">
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="554"/>
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        </location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD64143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="585" mass="63431" checksum="5163B54E59BDCACF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB56</accession>
    <name>M2SB56_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">COCSADRAFT_100758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD59720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007706522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SB56"/>
    <dbReference type="STRING" id="665912.M2SB56"/>
    <dbReference type="GeneID" id="19129721"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_100758"/>
    <dbReference type="eggNOG" id="ENOG502S3PB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026794_0_0_1"/>
    <dbReference type="OMA" id="KRAHFCF"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD59720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="422" mass="46376" checksum="DC3FF82C9887EDB3" modified="2013-05-01" version="1">MSIDINWDTITCGAEGSARAEKIRAFIHDRFQQVTLPRFIRSVHVHSFDFGSVAPEIEIKDICDPLPDFYEDDEDYPDEEGGEPEPEPDDEALHADDKLRDRETANPQRLHPDHAHVRPSQPRTKPSNKRGSLAPNEIGSPFFPGALTPGIPGGTSNMNYFHLPLSAGLSGAATPLAAVAGAQLHTWLDNPHGRPATPANMRLRHAASVNSLTLTPQSHPDPSSRPSSRHQQDEPKRPTFAGSDDGLSQDSYVRTPSASPNRMHEKSPDDIQVVTHVQYSGDIKMSLTAEILLDYPMPSFVGIPLKLNITGLTFDGVAILAYIKKRAHFCFLSPDDADALVGSDTGFNGLQTDARGQNPRPVQRPKIGGLLENIKVESEIGGQGSGKQVLKNVGKVESFVLEQVRRIFEDEFVYPSFWTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBS1</accession>
    <name>M2SBS1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_246908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704214.1">
        <property type="nucleotide sequence ID" value="XM_007706024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBS1"/>
    <dbReference type="GeneID" id="19135133"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_246908"/>
    <dbReference type="eggNOG" id="ENOG502RF8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015502_2_0_1"/>
    <dbReference type="OMA" id="FCYRIEA"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="583" mass="64354" checksum="74D44B8C9ADF5192" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCD2</accession>
    <name>M2SCD2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein root UVB sensitive/RUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_151456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704337.1">
        <property type="nucleotide sequence ID" value="XM_007706147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCD2"/>
    <dbReference type="GeneID" id="19131558"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_151456"/>
    <dbReference type="eggNOG" id="KOG4249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015325_5_1_1"/>
    <dbReference type="OMA" id="KWGNLAE"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="52"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="482" mass="51524" checksum="D556BF515E559B18" modified="2013-05-01" version="1">MSLQPAILAQMSEQDEAGKVVRTYVLSSSSSAVGEHGKHGEGKRVDVIVPKQAHKSVLQYIIDVFLPSGFPQSVTEDYIEYQVFDSLQAFSSSIAGMLASRAVLQGVGVGDSNATPTAALLLSVLQESVGRMATIAFADRFGTALEPECKMYRLTADILNDSAMILDCLSPGFPKPLRVAVLSFASCLRSLCGVCAGSSKASLSAHFATAGNLGEVNAKDSSQETVISLLGMLAGSFVVSHITSDLATWCTLILLLAIHLATNYAAVRAVSMQSLNRQRANILFSHILQHGIVLNPKEVSARERIFERGGVLRWADDEVLGKCRIGTSLSELLGRIGRRDKLSGSLAFCSSGGDDGSEVDVFDLLSIFEAEDYVLWATGGPAAYEAVIVLKAGCGPIDQLRAWAHALLVAEKRQRGGDSGGTRAKHGLVVGDLKDTLYEVRRMFDKYGDEMRAKGWNLDVAALETKAGMRLQISSTGPCTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFF8</accession>
    <name>M2SFF8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_174478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703472.1">
        <property type="nucleotide sequence ID" value="XM_007705282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFF8"/>
    <dbReference type="STRING" id="665912.M2SFF8"/>
    <dbReference type="GeneID" id="19132916"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_174478"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054430_1_1_1"/>
    <dbReference type="OMA" id="LVNWTCD"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="301" mass="34026" checksum="E56CBD45135BC64C" modified="2013-05-01" version="1">MAFTILDKSGRVYVQRELLQECKDPRLNISKADIFMRVAKPFYDLSLRLAADFPESRRLHMHIDSSEEESVLIYPFYQHTLLGMLQQDPEISGAAKKKVLQETGDAMQELHSKDWIHRACDEEGTKTITDVALGDFGLAFRFKTGALLSNTRAVGNAMWRSLEGQAGRGLSKVSGIYLFGLICIYTLGGREPLLINDYPELAKLGVSPQQAVLTRHFSCFGPANEGLLNVIDSEKWKKALRILSEMTYLVMQDQQDMSFEVWGHAFGSGAHKMISGMTKIDPRARPTINQIMEHLWWKEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SG31</accession>
    <name>M2SG31_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase ucpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_158345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697753.1">
        <property type="nucleotide sequence ID" value="XM_007699563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SG31"/>
    <dbReference type="STRING" id="665912.M2SG31"/>
    <dbReference type="GeneID" id="19131888"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_158345"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OMA" id="QVNDEDW"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF13">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD66203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27083" checksum="53B47A7B3F9CD5B6" modified="2013-05-01" version="1">MAATKVALITASSAGLGAQIARALAPDFRVVINYSSNSDRAQSLIKELTSIPGTSSEANPRFHLVQADMSSKPSVQNLVKETLEKMGRLDVVISNAGWTRMTTFTDIEQQVNDEDWDKCFTMNVKTHLWLAYAAKDALAETEGTFISTASVAGVKPSGSSVPYAVTKAAQIHLMKSLAVILAPKIRVNSISPGMLLTEWGLKFPESKRNAAINNTKLKRLATVEDCADQVRVLALSRSITGQNICIDGGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGU5</accession>
    <name>M2SGU5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_39314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702623.1">
        <property type="nucleotide sequence ID" value="XM_007704433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SGU5"/>
    <dbReference type="STRING" id="665912.M2SGU5"/>
    <dbReference type="GeneID" id="19139471"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39314"/>
    <dbReference type="eggNOG" id="KOG0285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_72_2_1"/>
    <dbReference type="OMA" id="FAMCFDQ"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD61615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="499" mass="54488" checksum="F0F85E074AD7C5F1" modified="2013-05-01" version="1">MADTAASRPPSTAEQLVRMSSKRTREIFAADFASSAALDHASNDSFSIHPTSPAPSTAADQAGVASRIRNEYEHVRELPPALAAKMASAASTAAERRKKIKAQNAEEKASDPKMQKMIEGVSEKADKARDAQSMQLAVRAGGKGAAPNAHGPTPNRDQTSSSLVRKDVVRQAKPEWHAPWKIKTVISGHMGWVRSVAMEPGNEWFATGAADRTIKLWDLASGQLKITLTGHISAVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYSLSLHPTVDVLCTGGRDGVVRVWDMRSRSNIHVLGGHKGTISSIQCQEAEPQVISGSMDSTIRLWDLVAGKTRTVLTHHKKSVRALATHPTEFTFASGSAQSAKQWLCPNGDFMQNFSPVNSIINTLSVNDNNMMFAGSDNGEVSFYDWKTGHRFQHTESIAQPGSLEAEAGVMCSTFDASGLRLITGESDKSIKIWKQDENATEETHPLDWKPTLGRQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SI06</accession>
    <name>M2SI06_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_85124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698229.1">
        <property type="nucleotide sequence ID" value="XM_007700039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SI06"/>
    <dbReference type="STRING" id="665912.M2SI06"/>
    <dbReference type="GeneID" id="19141042"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85124"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_7_0_1"/>
    <dbReference type="OMA" id="IMLEWAN"/>
    <dbReference type="OrthoDB" id="4161196at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1097" mass="124564" checksum="4EA4B9167B972228" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SII7</accession>
    <name>M2SII7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_168267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696779.1">
        <property type="nucleotide sequence ID" value="XM_007698589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SII7"/>
    <dbReference type="GeneID" id="19132564"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_168267"/>
    <dbReference type="HOGENOM" id="CLU_094266_0_0_1"/>
    <dbReference type="OMA" id="WLRPIPL"/>
    <dbReference type="OrthoDB" id="10396890at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="264" mass="28692" checksum="4C2D03D7B58F0EA2" modified="2013-05-01" version="1">MRPSRSLRPGQGSQARESGRGRGASSHNQTTSRNYRNERDYQNLDTLPPPAHWLQPTPAIVQYNFHHHLPIGGTSQVVQTHSSTGYIVGDVFVPISSTITTTVSTESHMEYGSPLEAYSPASEPPEPLPSHLDSHYFDNVGSQFAAEGTPSLAASDGSGDYTGIQDDRSPYPPVMDVANDGRAGGFDPARMPDLNKGGEVDSDRTDLLPSDPSRAYLESFPDEAWLRPIPLRIRRASTFPLLGQYGDATENLADNLETLQVTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJ41</accession>
    <name>M2SJ41_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_287333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696924.1">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MRX11"/>
    </dbReference>
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        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="241" mass="27644" checksum="0E6089EDA39EB87B" modified="2013-05-01" version="1">MEAYPKPRHQYIYTPRYGQRGILSYAGQAPNGAAPTGIIGGAYAYGFGYPAAAACQPVVYNTRPFYGPTYLYPYYNPGYTYYNSYPYGSLYPLANFYFSYQRSYYNTVPTYGYTAHVYPPGHATTTTTTYHVTNAQAPLYASPTAQLLRETRPAYAHGHAYTPQAPTREEIQLENRRIATQRGAYDARKIRPADARDDDPFWCREVNGEWHLRSYYQIENECHPGRWMMDAEIGFLVFHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SK23</accession>
    <name>M2SK23_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_34318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696591.1">
        <property type="nucleotide sequence ID" value="XM_007698401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SK23"/>
    <dbReference type="STRING" id="665912.M2SK23"/>
    <dbReference type="GeneID" id="19137588"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34318"/>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011526_0_0_1"/>
    <dbReference type="OMA" id="MIWLREN"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
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        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="826" mass="91787" checksum="4B5028BBDF503FD6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKT6</accession>
    <name>M2SKT6_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_158136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697347.1">
        <property type="nucleotide sequence ID" value="XM_007699157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKT6"/>
    <dbReference type="STRING" id="665912.M2SKT6"/>
    <dbReference type="GeneID" id="19131874"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_158136"/>
    <dbReference type="eggNOG" id="KOG4660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444140_0_0_1"/>
    <dbReference type="OMA" id="QMKLYAC"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="352"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="652" mass="73335" checksum="C0F3E1BCE82856C9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLU2</accession>
    <name>M2SLU2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_80313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695821.1">
        <property type="nucleotide sequence ID" value="XM_007697631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLU2"/>
    <dbReference type="GeneID" id="19140782"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80313"/>
    <dbReference type="eggNOG" id="KOG4561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034597_0_1_1"/>
    <dbReference type="OMA" id="AQWYNGM"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="69"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD68133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="392" mass="44599" checksum="78CA930E8B529C3B" modified="2013-05-01" version="1">MHDPFPIARPESLVKYVQPVADYLSLNTLPLHFHEVAVAYVLYDVTYRFIAPAFSRIFFPRVYATFNARTKLNWDVHIVSFVQSTLICALALWVMWTDKELNSMDRIERVHGYTGASGLIQAFAGGYFLWDLVITVQNVKIFGIGMLFHAISALCVFLLGFRPFVNYYACTFILYELSSPFLNIHWFCDKLNMTGSTVQFVNGLMLLFTFFSCRLVWGTYQSIRVFGDVYHLYMTGQVPQYDPEVGKLSDDTHVNNAGFKNDLLQYSAGQTIPLWLISAYLASNLTLNGLNWFWFSKMIETLRKRFDPPIGTKKAQPKVSAAPVEIPENEKVLIEGIHVSTPGVVEKDTEDYVNVASPRSLQFQKNKSGTHLEVKQSEVRSRNPSQRAAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMM2</accession>
    <name>M2SMM2_COCSN</name>
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        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_33329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695516.1">
        <property type="nucleotide sequence ID" value="XM_007697326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMM2"/>
    <dbReference type="GeneID" id="19137138"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33329"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OMA" id="MGAYMIG"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025116" description="Peptidase S8/S53 domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="149"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD68413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="405" mass="41917" checksum="071214CC13E22FC0" modified="2013-05-01" version="1">MHSFKTVLALGALLPAFLAQASKIIRTRNEHTIPGSWVARIEENEVLEAVLSTVLEAAGIESKETYSVGGVKGFTFDADDTILDMLESMGAIKSVEPDYKMYASVPVGSLNARQTNGTLTTQKGSPYGLGRISHREPGTRDYVFDSSAGEDTFIYVIDTGVNTEHTDFGGRATLGKSFISGSDGEDDQGHGTHCSGTAAGTKFGVAKKANIIGVKVLGADGSGSNSGVLRGIQWAVDDATEKGHINRTVLSMSLGGPFSQTTNDAIQSAVEAGAFVAAAAGNEGEDASNSSPASAPQACTVGATNERDLKASFSNFGKLVDIFAPGEKIQSAWIGSSTATNTISGTSMACPHIAGLAAYLIALEGPRSPTALCKRIQELATKDAITNLRAGEGSPNLIAYNGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMQ7</accession>
    <name>M2SMQ7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_358071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700654.1">
        <property type="nucleotide sequence ID" value="XM_007702464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMQ7"/>
    <dbReference type="GeneID" id="19138534"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_358071"/>
    <dbReference type="HOGENOM" id="CLU_047660_0_0_1"/>
    <dbReference type="OMA" id="EEGWIWV"/>
    <dbReference type="OrthoDB" id="3674062at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="473" mass="54049" checksum="1CD43FE8248E3169" modified="2013-05-01" version="1" fragment="single">MEALPNELLLEIIKQLFLEAFSTVLNIGLVNRRLHRLTNELLYSTYSLDRGNPALFIRTLASWPAHARRIQSLEWDCRPVHNNSLVTSDAFRFPGDLAPIERRNITKALGSKNPYETDDLNSILMDAGTDAYLNLFLSFAPDVCDIRIAIPSKWNYHAVWFTSSLGLRILSNLNKAYIVGPMRIRNVIPLFLVPSLRILTLDHVAHDRNRVLRGTFKWYGHDAAIQRLRKEKSWVESFHLQKCSTDTVEIAQLMPLFGRLKTFEFEFTGHDKDEANTTITHFVHSITNQSNSLKSLFLKDFRLALDPTALKGLSKLEHMDFLLLDMTMMCGSYLQKTTVESLSSVLQHLPKRLQHLHLIANDPDGEELKPSTAFTDALHGIAPIMKSILPALHTLKIADWDPLLGTFTCQTQVKAIQLAFAKIGVDFLWQPRDILINESNENDIITLEGKEEGWIWVQWVDSDELWNEGRNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ13</accession>
    <name>M2SQ13_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_260939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705334.1">
        <property type="nucleotide sequence ID" value="XM_007707144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ13"/>
    <dbReference type="GeneID" id="19135420"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_260939"/>
    <dbReference type="HOGENOM" id="CLU_3014048_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="56" mass="6405" checksum="F90F9D4B44FE21D3" modified="2013-05-01" version="1">MCVRACVRRLIQSLVWVFFSLLFGATPTYSLLRVAGAWCWEVMGLSSGYKSRETWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR18</accession>
    <name>M2SR18_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_177396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694945.1">
        <property type="nucleotide sequence ID" value="XM_007696755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR18"/>
    <dbReference type="GeneID" id="19133083"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_177396"/>
    <dbReference type="HOGENOM" id="CLU_2775769_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026045" evidence="1">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="69" mass="7287" checksum="8398C71DAA07C1F0" modified="2013-05-01" version="1">MNSFLLLTSLILASSVQARPAGNTPAPLPSSMTLDPVPGALPEDLPKVLPERRQVDLCTMFPIACPGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR98</accession>
    <name>M2SR98_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_87740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699375.1">
        <property type="nucleotide sequence ID" value="XM_007701185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR98"/>
    <dbReference type="GeneID" id="19141203"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_87740"/>
    <dbReference type="eggNOG" id="ENOG502SQZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040949_0_0_1"/>
    <dbReference type="OMA" id="GAFKGFY"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="404" mass="44798" checksum="1506A165AE85F592" modified="2013-05-01" version="1">MPGPYTFSPSHTRGDSRNSCFDSTRRYSLASETTGRQVIDSDAHETRKRSRYGDNAAQGSWSDYPLSNNRFVNNKSPPPLANDRYELAGGMDGPQTFGRRDGDYDDYFNLQSQRGTWSVPPTPQVGLSTQAAAGEMHTTPNGSKAWSLISLVGGVAGKLFEFCTVPFRGFQAGSGQKYNIESNADVAEKLGLQDDPYHPGPVQQPTPGTFPRDDYGIQPFPSITPERPRLAKRLRTTDNWVMVGTDCETESRPGTPRLSERRLPGHGRSPSSQIPRPVSRANLSTPSQKRPSLIPVSRRSTTDRHSLHSPAPSLSKFSPGTPAPSRSYSRLSYGSPTAFFDKNTSVASPLPQESQRLIDKVRREEMEEDERMRRMSLQMSAMLKEANEALGAKFEVEMFDDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRP6</accession>
    <name>M2SRP6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_194211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD59477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705174.1">
        <property type="nucleotide sequence ID" value="XM_007706984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRP6"/>
    <dbReference type="GeneID" id="19133881"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_194211"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_25_1_1"/>
    <dbReference type="OMA" id="QEHIQWR"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="240"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD59477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="787" mass="86944" checksum="678EBC5FA5E15D7D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRW7</accession>
    <name>M2SRW7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_215861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695142.1">
        <property type="nucleotide sequence ID" value="XM_007696952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRW7"/>
    <dbReference type="GeneID" id="19134491"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_215861"/>
    <dbReference type="eggNOG" id="ENOG502QS1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_7_0_1"/>
    <dbReference type="OMA" id="RDFISVW"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008119">
        <property type="term" value="F:thiopurine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259:SF11">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD69973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35448" checksum="B023391FAC7202AD" modified="2013-05-01" version="1">MATQNQDRLRTLFSSAPDSDHSNRWDNLWREATFLPWDRGHANPALIDVLSERSRPISSPDPNPSLGAPPPNSESAGYVSLPGPLRDDGKRRRVLVPGCGKGYDVALFAAYGYDAYGLEVSSHAAEAARKYLADPGKGPLEGEYAIKDEKIGRGAMKVVCGDFFDDGWLKDVDGWDGDEGFDIIYDNTFLCALPPSLRPKWASRMTELLRQSSSNNTGTGGVLICLEFPTHKPVNSGGPPWSLPPLVHTELLRQPGRDISYDDQGVVTKTDREDADNALVKIAHFTPRRTHEIGVIQGLVRDCVSMWRHKADCPEEQRWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS36</accession>
    <name>M2SS36_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_184508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704193.1">
        <property type="nucleotide sequence ID" value="XM_007706003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS36"/>
    <dbReference type="STRING" id="665912.M2SS36"/>
    <dbReference type="GeneID" id="19133463"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_184508"/>
    <dbReference type="eggNOG" id="ENOG502S7YV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070882_2_0_1"/>
    <dbReference type="OMA" id="KAKCFYF"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="130"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="191" mass="20728" checksum="ED49551512E86D38" modified="2013-05-01" version="1">MSVTTDGLDDVYEALERYNWDDDVEFQAGLQAIVGSNSTPEQTTELALRARCFYYARKYNKNIDFDAYKAYRNARNRPPPSPPSSTNVLASSVIDQELPSTTTSATTPATTTEPSGTLPSPPTATEPPAPYPTSFAHIVELITSGKPVPGIKEIPPTVLEGQGTQATKPKRKKPWEKDDVPVEAAKEASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS58</accession>
    <name>M2SS58_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_126038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704204.1">
        <property type="nucleotide sequence ID" value="XM_007706014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS58"/>
    <dbReference type="STRING" id="665912.M2SS58"/>
    <dbReference type="GeneID" id="19130647"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_126038"/>
    <dbReference type="eggNOG" id="KOG2771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024580_0_0_1"/>
    <dbReference type="OMA" id="HEPCVAC"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="275"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="424" mass="46735" checksum="4B76122E1FA095D7" modified="2013-05-01" version="1">MSTQSALAGRLVPLRTKDEVRASLETQPVYVVEVPAKFANAIKDAVQAALPDFRTSEISHLRRVVQFKYLPPHLQKDFYPPTRLPRGDEDDPALAFLSSSPASSPAQSGSAQTADEALTEHFDLVRYFLLCPTRYLSRADLVAIIRTCPPYDAKTTLPRIFHVTVPALAPISADQAAQWSNTYWPISYKNTNPYGPHPSLVQRNQDEIQPGAGTYLGLARAVGAQISDGCLGEEIGVVVVDHTKTKPEIIVVAGDCRWRSFTGTAEPHTGTGNVMAHSVLRAIAMVAKKRLRAASTDPVYLDRPLFCDSPLTSVEQEYFDTNNIHSSGYLCVDLDIYLTHEPCVMCSMAILHSRFRRCIFAKRMPHTGGMTADSPDNSSTAPTGLKNGLFWRPNELNWKFLAWEFKEDGEPAHGATGLNDTLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSF0</accession>
    <name>M2SSF0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_347387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704735.1">
        <property type="nucleotide sequence ID" value="XM_007706545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSF0"/>
    <dbReference type="GeneID" id="19137835"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_347387"/>
    <dbReference type="HOGENOM" id="CLU_1137901_0_0_1"/>
    <dbReference type="OMA" id="PQRYSHP"/>
    <dbReference type="OrthoDB" id="10498090at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="244" mass="26876" checksum="D6999DD2B1CA1141" modified="2013-05-01" version="1">MVCQAVRRLLAGGPAGMLDCLERCLGPERLVLVMLWMDVKAEMPTQSGTRLGHKQRGSMMVPPVMRSTMTTQHARRHGGVRCLNAMRGTGVRQGRPAGAESPFDKPQRYSHPQDDGQWLWHPSSPLAPENTHTYAPPASPPLLPPTPLRRDACPAPSSQLPACAVVWHSSKQRQHQAYQGRRLAALHAATWPDADAPIRLAINPITLGHEPFRSVQGAENRIHQLCVLSLRRIMSTYPAIPTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSM9</accession>
    <name>M2SSM9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_87523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698495.1">
        <property type="nucleotide sequence ID" value="XM_007700305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSM9"/>
    <dbReference type="GeneID" id="19141188"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_87523"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="OMA" id="TWRNYTL"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD65305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="522" mass="57190" checksum="9249E94B59662588" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSW0</accession>
    <name>M2SSW0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_48828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
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        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Steffenson B.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
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        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oxidored_molyb"/>
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            <end position="365"/>
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        <location>
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            <end position="512"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="64529" checksum="363E8055057F6E64" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SV12</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_163957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_163957"/>
    <dbReference type="eggNOG" id="ENOG502SZ4K">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="401" mass="43249" checksum="5BFC53807570D189" modified="2013-05-01" version="1">MAAYHTPSQTPSRRVLGNITPKALNTPQTQTKAYEASQASRAESPLKHVTPNTPTHFVDKENLTTPNATVKSKKRGIEEVDGAETVGSAKMLAHARDDSPSNTGARLTADAIQKHTENNPIGLADPGSPTERATPSPSPEPEPEPGLIQASQKSNQSFSDFLNYEMCASQRSDPGKEQERPAALAPAPPVTETKTKSRAEQLRTRLKFGLYKVKTNQVNKRDVDIIAPYEASALYSSNTINASKSTATTYSSESQGTGCVPNITISSPQRDQGPVFVKANLDPFRAISKLGPAPVQFALPPSGMSSSRTLQQYEITSSPPAVELPKSATPEQLMSPVRQGDHYQMIAGSGMRNDGYRAGESARERLQRLKQEQYTGEGLLNSIGVQGDAAEGLLQLMQHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWG6</accession>
    <name>M2SWG6_COCSN</name>
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        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_35146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697591.1">
        <property type="nucleotide sequence ID" value="XM_007699401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWG6"/>
    <dbReference type="STRING" id="665912.M2SWG6"/>
    <dbReference type="GeneID" id="19138092"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35146"/>
    <dbReference type="eggNOG" id="KOG3464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12029" checksum="A8AD95737B949369" modified="2013-05-01" version="1">MVNVPKTRRTYCKGKDCKKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKRAKTTKKVVLRLECTACKTKAQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_301475</name>
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    <organism evidence="8 9">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
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    <dbReference type="eggNOG" id="KOG1039">
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    </dbReference>
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    <dbReference type="OMA" id="YDMIPTI"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MKRN-like"/>
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        <property type="entry name" value="Znf-CCCH_4"/>
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    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
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        <property type="entry name" value="Znf_CCCH_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
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            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="658" mass="70358" checksum="81141E437D68061C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
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    <dbReference type="OMA" id="GVFDKEY"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="287" mass="32329" checksum="A68C8AE55EFA4616" modified="2013-05-01" version="1">MSELTNTRVPTPSNPSNLAPRYEIRKLKPVHLPWATAILAHSHGFHSNVWQKIWPDRDLGRWVVENSLNFEYLVRHQIDSGLSFGVFDTEYEFRTDTARATGGALLWDAAELNTESVEKTQGRAAESKRLLNQMDFPLVSIILSYDGFAPLSPKKMKPLLAAWPEFPILYGALEQRDQRDPASWKPTAPRQVLMRNATSTRGDYEGRGVMGAAARWLQREAALMGFRGIQIEAMADKVIRVWMEGVQKPFRGTVVSEFECQTLEVDGEGPFGAATQRIVKAWVDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX86</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_282845</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <lineage>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="161"/>
        </location>
    </feature>
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            <end position="193"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ND90Pr / ATCC 201652</strain>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD67355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="285" mass="32120" checksum="DBFC0F27C5DF195B" modified="2013-05-01" version="1">MSQFQFGADSRSGSSDDSDDDNISTLPFATPLRRSDFLAPDFSPASYLSTLHNRHQTLEDLRSELRSRSQLLSKELLDLVNSNYQDFLNLGNSLNGGEEKVEEVRVGLLGFRKEIDGLMDVVGKREEEVRELLEQKRDVRRKIEVGRRLIDYDARLKELEAELMIETSGQEPIIVGEEVSDSDEDEDEDEEEGSYTISVAKLRRNVVQHQLLLGLEKELDEHPFVAAQAARKSKVRTTLLMDLSTALRQAKSAGADGSGRVMKIMKIYADMEESAEAVKILKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZ34</accession>
    <name>M2SZ34_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_38984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702163.1">
        <property type="nucleotide sequence ID" value="XM_007703973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZ34"/>
    <dbReference type="STRING" id="665912.M2SZ34"/>
    <dbReference type="GeneID" id="19139390"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38984"/>
    <dbReference type="eggNOG" id="ENOG502S03H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_5_0_1"/>
    <dbReference type="OMA" id="AMGKYDK"/>
    <dbReference type="OrthoDB" id="9975943at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="241" mass="26544" checksum="FA3810C3050478D6" modified="2013-05-01" version="1">MHLILTGATGLVGASVLHNMLAQESISRISILSRRPVKMAEGHAKAKVIIHNDFSKYDEALLRELKDAHGCVWAQGVSQNAVSKEQYLQITHDYPLAAAQAFSSLHPDSPFTFVYVSAEGATQSPGIFTTLYARVKGQTESALFDFGKKNAMFKVYNVRPCGVDWSGHPEIHPFIPRQDMFKKVVLPALNVVWSSMMTPTREMGKVMTELAMSRGEPLEGPDVGMEGRLLSNIALRRMGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZ38</accession>
    <name>M2SZ38_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_343867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702494.1">
        <property type="nucleotide sequence ID" value="XM_007704304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZ38"/>
    <dbReference type="GeneID" id="19137626"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_343867"/>
    <dbReference type="eggNOG" id="ENOG502SPC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_940101_0_0_1"/>
    <dbReference type="OMA" id="QASETNC"/>
    <dbReference type="OrthoDB" id="3694323at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="296" mass="32701" checksum="8F1901BB83A4B638" modified="2013-05-01" version="1">MVTGSTVFEYNALPECTSSCKIIQASETNCVPPVSNHFTYQDCVCQSTYLGSLQKSGAICHGACSDEDDELIHEYYNRMCGQSNIPETTTSRLPPTTTLSTLITGYKTLVTVQAPMKSAPPPQQTHVEVIENQEPWLQQNGKYFARIGGGVVILIAILLVLVHLYKRHNRKSALENAGQRHPFIPLQDVNPLPNQPFGPATHQQPSLQPHSSSESDLGYSSRFPGITRPQPSFTFGATVRAYASDSQNDLHEMQHPTGRCGTLCRSLSRTERLIIERIRTTGRPDIPISATPKIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZG5</accession>
    <name>M2SZG5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_38952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD62167.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="264" mass="28702" checksum="DFE24AFEA2F2B7A0" modified="2013-05-01" version="1">MAALYTGAPPQGGPGYSFKQTPTTVSSGERQHGFYPYTDNGGSTLGISGADFAILAGDTRSTSGYNINTRYAPKLFKIGGEGSDSKGARIVLSVVGFAADAHALKERLDTIVKMYKYQHGKPMTVSACAQRLSHILYNKRFFPYYVHAILGGLDEDGKGALYSYDPVGSYEREQCRAAGAAASLIMPFLDNQVNFKNMYEPGSGVGHELKSKQAEPLPRDHVEDLVRDAFTSAVERHIEVGDGLQMMIITKEGIAETYTPLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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    <organism evidence="7 8">
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        <lineage>
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            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007703659.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SZX4"/>
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    <dbReference type="eggNOG" id="ENOG502RZKF">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016846">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CENP-V/GFA"/>
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    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF8">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mss4-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
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            <end position="252"/>
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        <location>
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            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
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        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51891"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="279" mass="29363" checksum="E7B606C7DEA1A993" modified="2013-05-01" version="1">MRSSLSVRRLSRRSASIRTQQAPPPPQQHPPSTSTLEAKTALPAAFQRDYSATATQGPTLRSCSPPISSTRRTRASTTTVIPGRSTYRSKLDPAATAETTTTTITAPYFGLTGLSSPTSPSTSGVPPAPAPAPAQEATATCLCGAVHLAFPTTTPGLVASFVCYCADCRKGGAEAGVVVKDEYLKHLRGTLNLSSFSQSVFTPSSHSSTTFFCQACGSNMYRVGVAFPGCAIVRLGTVDDARLAEGMLRPTRELCVKERASWAGGVKGDEVKRRVGLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703783.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19140410"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_63607"/>
    <dbReference type="HOGENOM" id="CLU_1180724_0_0_1"/>
    <dbReference type="OMA" id="SEHNFAH"/>
    <dbReference type="OrthoDB" id="3673440at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="219" mass="25007" checksum="D104E85B1DB8A241" modified="2013-05-01" version="1" fragment="single">VYLNDKLKKKEVEKAVQVTRQSQVRFGFIGKDSESEQMRDNFLLRFPPEIRNLITEYVLSLGDGTAGNVLIACPPGPHKPLCEGLSILSLCKQLTIEARSMLEARTTAYIPIMADMNFCKLVSDMNENGNASLPEIQSTVFAGLTSFRHAHFYLHVKYHSSLFRRYSEPDLSEDIAHIYDVLKQAFRIWRAASEHNFAHLKEQGLKRKAILHLDHLFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0I5</accession>
    <name>M2T0I5_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_156524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695770.1">
        <property type="nucleotide sequence ID" value="XM_007697580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0I5"/>
    <dbReference type="STRING" id="665912.M2T0I5"/>
    <dbReference type="GeneID" id="19131769"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156524"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_9_1"/>
    <dbReference type="OMA" id="WCSKYAQ"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="180" mass="20081" checksum="3319E048B2F292AF" modified="2013-05-01" version="1">MDGLSGAASVIAVIDIFAKIVSLCVQYSTDVKDAKNDIGRVQKKADAINRTLERIKQLLDSQDKTCPSATKSLFDSLQQCLKELKDLKLELEPGKTRRGMSRYGLRALKRPFKSKQVDKIVLNLSGYEQTFNLALQVDQTTLLLSIEQKLGLPKLPVATGAYFNSHDEEHNARCLLNTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2T2</accession>
    <name>M2T2T2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_200930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701526.1">
        <property type="nucleotide sequence ID" value="XM_007703336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2T2"/>
    <dbReference type="STRING" id="665912.M2T2T2"/>
    <dbReference type="GeneID" id="19134165"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_200930"/>
    <dbReference type="eggNOG" id="KOG4346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005799_0_0_1"/>
    <dbReference type="OMA" id="AGIMVKL"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000004">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000007">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="583"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD63347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="950" mass="105394" checksum="6ED0122856B31BFB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T408</accession>
    <name>M2T408_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_356764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD63986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699906.1">
        <property type="nucleotide sequence ID" value="XM_007701716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T408"/>
    <dbReference type="GeneID" id="19138452"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_356764"/>
    <dbReference type="eggNOG" id="KOG1807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407684_0_0_1"/>
    <dbReference type="OMA" id="WAFLEEA"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="8">
        <location>
            <begin position="600"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD63986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="674" mass="76190" checksum="EA90A1AF34B0DBED" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T414</accession>
    <name>M2T414_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_90624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700778.1">
        <property type="nucleotide sequence ID" value="XM_007702588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T414"/>
    <dbReference type="STRING" id="665912.M2T414"/>
    <dbReference type="GeneID" id="19141358"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90624"/>
    <dbReference type="eggNOG" id="ENOG502QV1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155618_0_0_1"/>
    <dbReference type="OMA" id="YLKVATH"/>
    <dbReference type="OrthoDB" id="3686395at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="136" mass="15399" checksum="9A95E98FB6A15EE5" modified="2013-05-01" version="1" fragment="single">QVLQDYLKVATHVLPNDVKLLKPTLWHSDLHTDNIFVDPFQPTKVLNIIDWQAANVSPLFLQARHPSFTKFEGPIPEGVKPIPHPDNFEDMDEEAQYQAKNLRAAQSVYKPYGIYIHARAMSGDCSCAAISRQSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2T519</accession>
    <name>M2T519_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_142185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699971.1">
        <property type="nucleotide sequence ID" value="XM_007701781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T519"/>
    <dbReference type="STRING" id="665912.M2T519"/>
    <dbReference type="GeneID" id="19131235"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_142185"/>
    <dbReference type="eggNOG" id="KOG2424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062463_0_0_1"/>
    <dbReference type="OMA" id="TQPNVYQ"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD64077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="287" mass="31381" checksum="EE9C80FA7D1F8132" modified="2013-05-01" version="1">MSADPRLRARQQQQQATPTAVPPPPPPPPAEPQSVGMDGAGDAQPDQNVVPDNSFKLKFCTVCASNQNRSMEAHLQLASAHLPTISFGTGSLVRLPGPTITQPNVYHFNSTTYRAIHDELAEQNAALYTNNGLLNMLGRNLNIKGYPERFQDWVPGKPRLDHAEDKGSQGTEAGVVDVVITCEERCFDAVLEDLHNKGGKLNRPVHVFNVDIKDNHEEALVGGKAILDLALSLNEAAAQEREIHGDSGWQSGGGAARSGFDERVPEILATWQERWPNMPALWSLAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5L1</accession>
    <name>M2T5L1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_177420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694966.1">
        <property type="nucleotide sequence ID" value="XM_007696776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5L1"/>
    <dbReference type="STRING" id="665912.M2T5L1"/>
    <dbReference type="GeneID" id="19133085"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_177420"/>
    <dbReference type="eggNOG" id="ENOG502QQ9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033363_1_0_1"/>
    <dbReference type="OMA" id="WLAERYW"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55286" checksum="53469C27B061F119" modified="2013-05-01" version="1">MGRHANPDIRRAFAEFQDQETPSKCNKVRCRHCGYVRAKNTTRQIEHLQECQAYLASSDAQAHLLAQQQQQQDGTPAEPNMAAGSSQIFSGQQPNPNLQVQRRGPNTSKRARDTQPIIAPKTVPVPTVMPSLTAHLLNVCAGPLRQATQRPFLSHAGCGSLTAEPLSWWLVQDGHYARGFIRFAGQLLAKIRLPQTPNSQFHPMYRTMDLLISALNNMRREIQFSEITATKYGLSLGTELPTPVTRGLMDLLISASSSSASLLEGMVVLWGTEHAYRAAWQYASTFSSSLPTSISDSHIAALHQVLIPNWTSPPAYKFLDATRALVDELANITTTRDGKEEMVRCEELFRQICWLAERYWPAIDENGGWIDPPMGYTIPGARPVTMNRNVIHPNMTGPSMHGPGMNMHGNPVNGNMAGPAPTPNMHGHVNTNMNNNANANPNINTSTNMNTNANNSNSNRNNSAPSAPINAGVRKESTSVNDNRSQQSMDRANSMDSDSGESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6R8</accession>
    <name>M2T6R8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_159940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699479.1">
        <property type="nucleotide sequence ID" value="XM_007701289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6R8"/>
    <dbReference type="GeneID" id="19131996"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159940"/>
    <dbReference type="eggNOG" id="ENOG502QW09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022148_0_0_1"/>
    <dbReference type="OMA" id="TWEYGNE"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025664" evidence="1">
        <location>
            <begin position="23"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="422"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="540" mass="59429" checksum="E783E6D6CDC6F060" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6U4</accession>
    <name>M2T6U4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_36061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699088.1">
        <property type="nucleotide sequence ID" value="XM_007700898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6U4"/>
    <dbReference type="STRING" id="665912.M2T6U4"/>
    <dbReference type="GeneID" id="19138651"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36061"/>
    <dbReference type="eggNOG" id="KOG3908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_1_0_1"/>
    <dbReference type="OMA" id="IDLFDCV"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025711" description="Queuine tRNA-ribosyltransferase catalytic subunit 1" evidence="7">
        <location>
            <begin position="26"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="256"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD64687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="410" mass="45301" checksum="5379B91A4A8E6D9C" modified="2013-05-01" version="1">MAPASMHSALAFELLATCSVTRARAATLHLPHGPVPLPIFMPVATQASLKGLTPDQLEDQGCCLCLNNTYHLGLKPGQATLDSIGGAHKLQSWRHNILTDSGGFQMVSLLKLAKVTEEGVRFLSPHDGSPMLLTPEHSISLQNSIGSDIIMQLDDVIVTTSPDHARMKEAMERSVRWLDRCIQAHKYPEKQNLFCIIQGGLDLEMRRECTVQMVARDTPGIAIGGLSGGEEKESYCKVVKTCTELLPQKKPRYVMGVGYPEDLVVSVALGADMFDCVWPTRTARFGNAITSRGSLNLRNAIYSEDFSPIEDGCNCTCCRPTSAGGLGITRAYIYHVTAKETAGAHLLTMHNVYYQLNLMKLVRQAIIEDRYPQFLREFFNKLYNGQKDKYPRWAVDALRGVNVDLLSNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6Y1</accession>
    <name>M2T6Y1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_32798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694376.1">
        <property type="nucleotide sequence ID" value="XM_007696186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6Y1"/>
    <dbReference type="STRING" id="665912.M2T6Y1"/>
    <dbReference type="GeneID" id="19136903"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32798"/>
    <dbReference type="eggNOG" id="ENOG502SMZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077703_0_0_1"/>
    <dbReference type="OMA" id="ARSAFAW"/>
    <dbReference type="OrthoDB" id="5272500at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD70165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="318" mass="34754" checksum="88CBC7779E8B84AA" modified="2013-05-01" version="1">MDNCHAIYTESPFAISQEDVDALNLSKAFCALRRCLAGQADFCASHSTCSPQAKQTWLLHRDILHALIMPIVTLFSRASTLASAALCTQRASDLELAFSGESRSAFIGLQCFITEEADWCHTRGCPACVVTETLSTDSHIRLTIAASLLSTATVATPTQEEPPSQDSQDRTLPPLPHILPALQHAVINDPFWEGSDIWSYILSRATQLSAGIQALIAECINLESLVSSPTTTDRPASKRGMTHPSVPFVAFGQAAPEKGVKLRKSKLAKRQLRLRDEEVELMRRVAMQCWAKAKVPKNLRADALALGESKRSRSLTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2T856</accession>
    <name>M2T856_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_88333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699608.1">
        <property type="nucleotide sequence ID" value="XM_007701418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T856"/>
    <dbReference type="STRING" id="665912.M2T856"/>
    <dbReference type="GeneID" id="19141233"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_88333"/>
    <dbReference type="eggNOG" id="KOG1069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_2_2_1"/>
    <dbReference type="OMA" id="SYKCPAT"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD65117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="258" mass="28142" checksum="9267018BF57B2020" modified="2013-05-01" version="1">MVVPTVTLTHLNRADGSATYTHNGYSIIGAVNGPIEVQRRDELPEEAAIEVNLRPAAGVGSPRERHLETLVHNTLRSIILTQSIPRTLVQITLQVRSLPEEDSTAGINTSLSLLPHLLHTALLALLSASIPLSTTLTSVMVAQPASPSSALLSPTANQLLRAKPIRSVHVFAFSGKRKMLLSESEGSFSYEDWNEACQMAEETCCGEDDSEDQGGIKLDVEGDAMEIDAQAEAESLDKWLRSVVKRKVEHEQRWRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8A7</accession>
    <name>M2T8A7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_116678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699648.1">
        <property type="nucleotide sequence ID" value="XM_007701458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8A7"/>
    <dbReference type="STRING" id="665912.M2T8A7"/>
    <dbReference type="GeneID" id="19130333"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116678"/>
    <dbReference type="eggNOG" id="ENOG502SVM5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068958_0_0_1"/>
    <dbReference type="OMA" id="DSFALYS"/>
    <dbReference type="OrthoDB" id="5397846at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="64"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="317" mass="35574" checksum="6E50A3EB77A492DD" modified="2013-05-01" version="1">MSAATASAETFASGRYSKRKRTQVSYHLDDLEYSDTESDFESPQAKKPKARTTKALPKRKIFPFLDLPAEIRNTIYNYALYDPSGINFVGTYQKKRRVAARVSAEYASNASGRYYSPTSKRVVEDVLDADGDHTSLVPSLLAVNKQIYSEGIDILYGNQLTFIDSFALYSFLINLGPTRAQRLKKLRILGWLHSRGLKVYNNACFAALAWATNLTSLVVHVRINKYCSPRRGADQFYRDAFPWLEAVGAAKGKRDAALDVVMLDDAYLSDPCDSDESVPSPEERVEQFKAELAKYLDAHRDGILAKPKNKMAKKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2T976</accession>
    <name>M2T976_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_86086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700426.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_86086"/>
    <dbReference type="eggNOG" id="ENOG502SN0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891389_0_0_1"/>
    <dbReference type="OMA" id="WRYINNI"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
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    </feature>
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        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="314" mass="35488" checksum="F952237809807FB6" modified="2013-05-01" version="1" fragment="single">IVPYSRYHGEDIPKGAVKQNDLLFWRYINNILYNPIFGLVKISFLITLSKLRSCNCWIIVSLWTLISVNALFIILAVFGGTFKCWPIQKAWETSIPGYCPPRAPYIFSTIGTTIATDFLVALIPAWIIHDLRMPLKNKLAVVMFLSLPLAVTAIGCWRLQTFIAVFSLPKGASEDPYNLRNALTIIEGNLGVIAACGPTPKWILGCFIPYFNTSLRSHVYTPNSLANRRHRVRGYLQSHNDIELRTDVLVVSYTQSTKNPSWKVCRDTGSAKQWPTLDAEKGTKKTTTVELECELLDMKPGQESKRPEPTLFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TB94</accession>
    <name>M2TB94_COCSN</name>
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            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_112905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697962.1">
        <property type="nucleotide sequence ID" value="XM_007699772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TB94"/>
    <dbReference type="GeneID" id="19130199"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_112905"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_7_1"/>
    <dbReference type="OMA" id="FQAFGSC"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005275">
        <property type="term" value="F:amine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF21">
        <property type="entry name" value="DITYROSINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="502" mass="54430" checksum="35381ACC84CF1ACF" modified="2013-05-01" version="1">MRSPIEFEKSHHYDQCRDSVESERSSSRHSVDEEAQQSFADDVPLAPCPPPAQPYSAFSLNRRRFILGVVTAAGFFGPLCGAVYLPSLRLFQKIFNASEAAINGTVSIYMVVFAIAPLFGAAASDVGGRKTVYMAGLGSFLIANSLLATLPAYIWLLYILRIFQAFGSCIVFSVGAGTVADITEPASRASALAWFLMGPQLGPILGPLIGGQFATESRWRWVFAFLSMTSFPVYLAIVFCMPETLRSLVGNGASVAKQPWISMPKFWTKPCTDTNVPKVPRPSFRKFMRLLKYPPHLIVCFNGAFQFAGLYGMYISFPTIWQEGYNWTTAEVGYAFLCPGIAMFLASIVVGRLSDYMRKKAIANSPDGKVAPERRIAIQIPGFLCAAAGKLMFGWFTLNHLHPALGLCGSALAAVGVSIVFVTSTSFQTECDPTQTASLVALGGFLRNVAAAICAAIMGGILDGMGWGWAFTGLGIMDLLCIPGIILILTRGAKFREELKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBK2</accession>
    <name>M2TBK2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DWNN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_34816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
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        </subcellularLocation>
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    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Common root rot and spot blotch fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    </comment>
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    <dbReference type="STRING" id="665912.M2TBL2"/>
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    <dbReference type="HOGENOM" id="CLU_005024_2_1_1"/>
    <dbReference type="OMA" id="IYAQAMS"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="GAL4"/>
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="PANTHER" id="PTHR47338:SF19">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
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        <location>
            <begin position="60"/>
            <end position="80"/>
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    </feature>
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        <location>
            <begin position="61"/>
            <end position="73"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66257.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="684" mass="77957" checksum="82F2A3614FF88069" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBR1</accession>
    <name>M2TBR1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_296920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697831.1">
        <property type="nucleotide sequence ID" value="XM_007699641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TBR1"/>
    <dbReference type="GeneID" id="19136101"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_296920"/>
    <dbReference type="HOGENOM" id="CLU_1547422_0_0_1"/>
    <dbReference type="OrthoDB" id="3689582at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="173" mass="19494" checksum="3C5233777CEF547C" modified="2013-05-01" version="1">MRVDCAKIENSVLYPLRCRSFTVFAYTRYLLHHPLSKPHPYFTFPDTNSNCWIQTPFLHEKPRLPVFDKAKPASTRPGRPSPRNWSANAFRGPLSCLPCRHRFRSLPFTSFTQITGLPPHNLREFLSPFSTVSTVFASSQTPTAISNNLQASYIMAKPLEGTTSSSSLSSISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCJ9</accession>
    <name>M2TCJ9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_33857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696482.1">
        <property type="nucleotide sequence ID" value="XM_007698292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCJ9"/>
    <dbReference type="STRING" id="665912.M2TCJ9"/>
    <dbReference type="GeneID" id="19137345"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33857"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037982_2_1_1"/>
    <dbReference type="OMA" id="TRCWYEM"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="373" mass="40442" checksum="A1945757D1F034DC" modified="2013-05-01" version="1">MSDLNSTDDDLLTRLNALKKSSVSLDTNYNASIAPAEPPKPTDDLAARFARLGSVSPAGSPQPSRTASTNNIRAPTVAPGASNYLEGVSQGVGSSNVEFNDEDEKSLEELLGELNDAIGDRKEWDVSKEEQQDVGKLLKDMRKILPEVVNSRAQGQGDKGKTEGLTDWESIEVNVGSGEVGAKQDSDEEVDEEGKKKTEDDEADDIIARVMAELEISKKYDPPSPASEDNKSDSGDQKLRNETTDNDLSLPSAPQDLPNPDTQAIEDDFTARLAALAAPSPSQTDALGLPSAPSFAPTKKPPVSTNLQKKIDEEIDTWCIICQDDATLKCLGCDNDLYCQNCWMEGHKGESAGFEERRHKAVLYSRKKKQTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCY4</accession>
    <name>M2TCY4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide hydrolase</fullName>
            <ecNumber evidence="1">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_157526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696845.1">
        <property type="nucleotide sequence ID" value="XM_007698655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCY4"/>
    <dbReference type="GeneID" id="19131830"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157526"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877182_0_0_1"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041015998" description="Peptide hydrolase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="3">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="317" mass="33726" checksum="1600F808CC98ACD5" modified="2013-05-01" version="1">MRYSIIFTALVASASASDKPAVSPVLLKSQILRDNLLASVRKLEDFANTDYTAEVADKITLIARGTCDYGIKSAYSGPAGAVGSILYNIDDRGPEDGTLLAPPRPEGPYVPTLNIIKNVSTPIVAALKRGEKISASFDVYSDIRNITSSNLIATTKSGDHNNKLIVGAHSDGVLEGPAINDVASGLNAVTFAFWTTQLAGYLPGSTHFIKNLTPADNAKTRAYLNFDLQYFKAAGTSTILKEYDGRSDHVPFVDAGIPVGGTSTGPDVQKTPEQAAIFAGTAVATYANSWEGFPKRTTSVAKRSLIRARDSNEKSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDP4</accession>
    <name>M2TDP4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">ATG12-activating enzyme E1 ATG7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-like modifier-activating enzyme atg7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_303242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698235.1">
        <property type="nucleotide sequence ID" value="XM_007700045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDP4"/>
    <dbReference type="STRING" id="665912.M2TDP4"/>
    <dbReference type="GeneID" id="19136222"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_303242"/>
    <dbReference type="eggNOG" id="KOG2337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012998_2_1_1"/>
    <dbReference type="OMA" id="RQIWDAI"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="12">
        <location>
            <begin position="360"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD66857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="716" mass="80006" checksum="7B1645058D255201" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF12</accession>
    <name>M2TF12_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_34611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696654.1">
        <property type="nucleotide sequence ID" value="XM_007698464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TF12"/>
    <dbReference type="GeneID" id="19137756"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34611"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_2_1_1"/>
    <dbReference type="OMA" id="KPFIVWM"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
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        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
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        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="78274" checksum="76F0A5F4363CA8C9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFJ1</accession>
    <name>M2TFJ1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="7">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_34304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="7"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696588.1">
        <property type="nucleotide sequence ID" value="XM_007698398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFJ1"/>
    <dbReference type="STRING" id="665912.M2TFJ1"/>
    <dbReference type="GeneID" id="19137579"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34304"/>
    <dbReference type="eggNOG" id="KOG3984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_1_2_1"/>
    <dbReference type="OMA" id="EGVYAQF"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="322" mass="34851" checksum="46C01362C093666E" modified="2013-05-01" version="1">MESTQDAAAAPNAYVRATETAKYVRSQLPETLQNPKVAIVCGSGLGGLADTIEPEPKVELAYGTIPYFPKSTVQGHAGKFVFGHIGPQKTPVALLVGRAHFYEGHSMDLVTFATRVCKVLGVETMIVTNAAGGLNQTYRVGDIVCLNDHLNMAGLVGFHPLRGPNIDEFGVRFPPLSDAYDLDLRRRTHKAWAKLGLDQQQRRLHEGVYAFVAGPTYETRAECRMLSMLGADVVGMSTVPEIIVARHAGMRILAFSLVTNVAVLEAGSCGNDATIQNMNRAQLTEHLSQGKANHEEVLEAGREAAKDMQALVKQILSDLGEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGT8</accession>
    <name>VOSA_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spore development regulator vosA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vosA</name>
        <name type="ORF">COCSADRAFT_62627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Fungal Biol." volume="119" first="884" last="900">
            <title>The regulatory gene VosA affects conidiogenesis and is involved in virulence of the fungal cereal pathogen Cochliobolus sativus.</title>
            <authorList>
                <person name="Wang R."/>
                <person name="Leng Y."/>
                <person name="Zhong S."/>
            </authorList>
            <dbReference type="PubMed" id="26399184"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2015.06.009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (By similarity). The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity). Regulates spore viability, trehalose accumulation, and tolerance to thermal and oxidative as well as ion stresses (PubMed:26399184). Positively regulates conidial pigmentation and pathogenicity on barley (PubMed:26399184).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimeric complex with VEL2; the formation of the VEL2-VOS1 complex is light-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is up-regulated in conidia (PubMed:26399184).</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal velvet domain contains a NF-kappa-B-like fold and is involved in DNA-binding.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Reduces the amount of thehalose in conidia, tolerance to heat, oxidative and osmotic stress (PubMed:26399184).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VosA subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EMD67942" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67942.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695649.1">
        <property type="nucleotide sequence ID" value="XM_007697459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGT8"/>
    <dbReference type="SMR" id="M2TGT8"/>
    <dbReference type="GeneID" id="19140401"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_62627"/>
    <dbReference type="eggNOG" id="ENOG502RYQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286061_0_0_1"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="PHI-base" id="PHI:5104"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000435788" description="Spore development regulator vosA">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Velvet" evidence="2">
        <location>
            <begin position="46"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="7">
        <location>
            <begin position="274"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q5BBX1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="26399184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="26399184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="26399184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD67942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="348" mass="39180" checksum="BB951B517124316C" modified="2016-03-16" version="2">MAFSYNYSLQASYPSQRAYVPYQQTQVPTPSPIYSLPITNTTTSGALSPSSCFLSVRQQPKEALVTVKGKEKFRKPLDPPPMLELKVSSDIDPSQQFLQNPYLFVSVSLYKHDKDEPIEGTPFDVLAGTLVSSLHRLKDVNNKDGAFFIFGDISIKVQGTYRLRFTLYELQPSYFTLSDLEQHKDLERYQGAALDPPEYGTYQCLGHVLSDKFNVVLPKDFKGLEESTYLSRAFSDQGVRLRLRKEARGMMSNKRSISGSGDLTSDQSQQQQQQQPLAKKRREDSVESANPSSLMSGFYQNVSPFVNTPYLQSQGLQGQTLQNQGLQAPVRHDTSYAWNLAYDPSFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2THB0</accession>
    <name>M2THB0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_156549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695790.1">
        <property type="nucleotide sequence ID" value="XM_007697600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THB0"/>
    <dbReference type="STRING" id="665912.M2THB0"/>
    <dbReference type="GeneID" id="19131771"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156549"/>
    <dbReference type="HOGENOM" id="CLU_2120884_0_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12841" checksum="B22EAE14F0B18E59" modified="2013-05-01" version="1">MANIYNDDLLCSECFLKLMHARISSEFLSDEDHSDYLVQEFQDIQNICQTTIAVNIATRSLPNYMVALTPTPSFIFINVMGTTSNNSMHTCNDIARQYNVSTGSLVYLTQNEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2THV1</accession>
    <name>M2THV1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_133856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695940.1">
        <property type="nucleotide sequence ID" value="XM_007697750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THV1"/>
    <dbReference type="GeneID" id="19130907"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_133856"/>
    <dbReference type="eggNOG" id="ENOG502SJ2F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="OMA" id="WCIRILM"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Dhillon B."/>
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            <dbReference type="PubMed" id="23236275"/>
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    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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            <strain evidence="12">ND90Pr / ATCC 201652</strain>
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            <end position="892"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        <source>
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    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD69121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="892" mass="99266" checksum="5D2DBE69445DA1B5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ87</accession>
    <name>M2TJ87_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_155461</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694645.1">
        <property type="nucleotide sequence ID" value="XM_007696455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ87"/>
    <dbReference type="STRING" id="665912.M2TJ87"/>
    <dbReference type="GeneID" id="19131700"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155461"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="AYFERDH"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000697">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000525">
        <property type="entry name" value="Serine/threonine-protein kinase KIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="7"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="388"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="479"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="692"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD69261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="745" mass="82580" checksum="BCCDD78BF22221DC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJQ3</accession>
    <name>M2TJQ3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_81454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696406.1">
        <property type="nucleotide sequence ID" value="XM_007698216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJQ3"/>
    <dbReference type="GeneID" id="19140833"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_81454"/>
    <dbReference type="eggNOG" id="ENOG502SXDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122062_0_0_1"/>
    <dbReference type="OMA" id="NDHPGRN"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052590">
        <property type="entry name" value="Stress/Virulence-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569:SF5">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 10 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11021" checksum="78740AAC1E37240A" modified="2013-05-01" version="1">MASSNPANFANLPKDELREIAAKGGHASHGSGHTDSSSNDHPGRNPDGTFTKGSEVAKDLGAQGGHASHGSDDSGSHAHKDSGRNPDGTFRKGSELASELGAQGGHTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKW9</accession>
    <name>M2TKW9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_186613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695014.1">
        <property type="nucleotide sequence ID" value="XM_007696824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKW9"/>
    <dbReference type="STRING" id="665912.M2TKW9"/>
    <dbReference type="GeneID" id="19133569"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_186613"/>
    <dbReference type="eggNOG" id="ENOG502QVDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017872_3_0_1"/>
    <dbReference type="OMA" id="EHLPMFF"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="484" mass="55418" checksum="252E3F096D8B3E62" modified="2013-05-01" version="1">MLPSYSTSKGKMHRHAFSNGAYPSQGGGTFSIQPHKFQPRSQPALRRRRTLIQRLLLVGSLFFTALFFFFPNLRPNLGSGPLSLITSSDDSQLETVRYYDLNNVQGTARGWEREERILLCAPLRDASPHLPMFFSHLKNLTYPHNLIDLAFLVGDSKDNTISLLTEKLKELQADPDPKQQFGEISIMEKDFGQKVNQDVESRHGFAAQASRRKSMAQARNWLLSAALRPTHSWVYWRDVDVETAPFTILEDLMRHNKDVIVPNVWRPLPDWLGGEQPYDLNSWQESETALALADTLDEDAVIVEGYAEYATWRPHLAYLRDPYGDPDMEMEIDGVGGVSILAKAKVFRAGCHFPAFSFEKHAETEGFGKMAKRMKFSVVGLPHYTIWHLYEPSVDDIRHMEEMEKERKAKEAEEEAKKAKEAKIKESFDEKKGDWEKEKAAVQELIQKSKSEAKEGEQKDKQLEEKKKEEAKEEKLTEKKEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2TM42</accession>
    <name>M2TM42_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_32455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694298.1">
        <property type="nucleotide sequence ID" value="XM_007696108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TM42"/>
    <dbReference type="STRING" id="665912.M2TM42"/>
    <dbReference type="GeneID" id="19136785"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32455"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="OMA" id="EGYNWGQ"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="329" mass="37481" checksum="737E0812C49E9963" modified="2013-05-01" version="1">MDTNMEDVKMPEPMQLSSAPTSEPTTIPTLDGWIESLMSCKQLAESDVQRLCDKAREVLQDESNVQPVKCPVTVCGDIHGQFHDLMELFKIGGPNPDTNYLFMGDYVDRGYFSVETVTLLVALKIRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALIDNQIFCLHGGLSPSIDTLDNIRALDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDEHLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2TNC2</accession>
    <name>M2TNC2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_217966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695296.1">
        <property type="nucleotide sequence ID" value="XM_007697106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TNC2"/>
    <dbReference type="GeneID" id="19134535"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_217966"/>
    <dbReference type="eggNOG" id="ENOG502RIMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069404_0_0_1"/>
    <dbReference type="OMA" id="NETEWWT"/>
    <dbReference type="OrthoDB" id="3695466at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD70177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="344" mass="38535" checksum="472F65E2B6C24C3E" modified="2013-05-01" version="1">MNQQPLLDTRPEIGHSRNGIQKNRMWLGHVHDSLSDEFGGVTYDRRCQTWDNQRGDDEIEGNSQSTRISPGIRHDILSNSSEATSPLISDTVPSQLQGSTREDEPSYHKQAIGSERLQEVQLDDNETEWWTGISDVSTLNHDNDLSVSAQRHNSIFTRKSMYCSAFTSNDTMPFDYFGYAEPVESFDPGSYSMRRITGISQDSGYFSTAGSVAPQTPPPNSSPTTSSFPPSKESESNPESVRCAQCEIIFAGRYGKGNLRRHTKSVHQTMGKTLTCNACHMTFARSDALRKHMLRKHRDLPPPPSKQTSTIQPSSHEHIFSSYYRSAPAPYLHADDLRGLADPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSC9</accession>
    <name>M2QSC9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_50959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445735">
        <property type="protein sequence ID" value="EMD58099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706201.1">
        <property type="nucleotide sequence ID" value="XM_007708011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSC9"/>
    <dbReference type="STRING" id="665912.M2QSC9"/>
    <dbReference type="GeneID" id="19140277"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_50959"/>
    <dbReference type="HOGENOM" id="CLU_2229441_0_0_1"/>
    <dbReference type="OMA" id="HATYVRA"/>
    <dbReference type="OrthoDB" id="3925403at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="106" mass="11543" checksum="C3930970BA6B946F" modified="2013-05-01" version="1" fragment="single">QLVTYRSPDQKRGLDAVVQGVSPLIVVLPTGGGKTLLPFTAAILDRSQQIDRLSVTILVVPFRALIEDMLVRLAQANIQAIEWQPGEIGELQRRSRLASVVVVSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSH6</accession>
    <name>M2QSH6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7888 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_185970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445700">
        <property type="protein sequence ID" value="EMD58139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706160.1">
        <property type="nucleotide sequence ID" value="XM_007707970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSH6"/>
    <dbReference type="GeneID" id="19133539"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185970"/>
    <dbReference type="eggNOG" id="ENOG502SWEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118201_2_0_1"/>
    <dbReference type="OMA" id="NWAYLVG"/>
    <dbReference type="OrthoDB" id="3685327at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057210">
        <property type="entry name" value="DUF7888"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25411">
        <property type="entry name" value="DUF7888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023386" description="DUF7888 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7888" evidence="2">
        <location>
            <begin position="51"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="178" mass="19178" checksum="D63825F3FD3445AB" modified="2013-05-01" version="1">MVQIASFFTLLAMGSSVFATPMVNIDTISVEQGLALRATNDLPNVARSPAAGAAAAAIAPVVIDIATRVVKMIDSIRDDVERRKQFTQRVASDVHARYPGFNIVVCNVGYKLEGPGYQNVVSTKYHAAVGADVTYDVVLFSSPKTFTRQGDGGFQNWAYLVGKQCRTDGGFIDCPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2QWQ9</accession>
    <name>M2QWQ9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_100576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704564.1">
        <property type="nucleotide sequence ID" value="XM_007706374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QWQ9"/>
    <dbReference type="GeneID" id="19129705"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_100576"/>
    <dbReference type="eggNOG" id="ENOG502SDVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604309_0_0_1"/>
    <dbReference type="OMA" id="PHEGPIG"/>
    <dbReference type="OrthoDB" id="5222339at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="171"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="414" mass="45161" checksum="4E81C2D6321F9D0E" modified="2013-05-01" version="1">MAYSAPPTGILSMDDFMKQNQDEHQAQREARYSTASPPIKKATTSENTTPLTPVVVGARSSKHTILLHEKYQALGIPQPLFTYEGNTISGWAASVSFPGLENVEELQGLSGDRRFNSKQEAKEALSEKAFAVLEEMERQGRVKKAEKNRKKSVGGQLEQQQNLTEREPVENYVGKLLEYQRSISGPQPTYTDYQSGTHFACLLTLEGQPHPFGTLTSLFSSKKAARQDAARHAVEHFKALGTWPQDTLIGGIKKKKQSKPASPPSPSSSSSILSPIQPPNLNSSISAGASSFAQQVAILAASLTLPTPEWKYTSHPSDPNFHSIACFFRSAGPHEGPIGEVRNVFGKKKAKEECARLTLEYLLDVREKRRAYGARMMAGVRGGEGVVGGVEGRRVESADGSEDEFVDAEEGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2QX18</accession>
    <name>M2QX18_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_203340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD59594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007706432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QX18"/>
    <dbReference type="STRING" id="665912.M2QX18"/>
    <dbReference type="GeneID" id="19134254"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_203340"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007931_0_0_1"/>
    <dbReference type="OMA" id="MDLQARK"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024036" evidence="4">
        <location>
            <begin position="25"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="863" mass="95707" checksum="7274D718A500029C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2QX66</accession>
    <name>M2QX66_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_252239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704657.1">
        <property type="nucleotide sequence ID" value="XM_007706467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QX66"/>
    <dbReference type="GeneID" id="19135246"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_252239"/>
    <dbReference type="HOGENOM" id="CLU_109434_0_0_1"/>
    <dbReference type="OMA" id="ERETHII"/>
    <dbReference type="OrthoDB" id="3695563at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="163" mass="18698" checksum="1F1D85E1476B7341" modified="2013-05-01" version="1">MSFFPIIPSTSLHSSILALPPPHHDHNHNHDQTPTHHAIHMDHLPSLLSHLLAPVSHTQCTSSMPCSTPPPLSESHPHQEERKERETHIIRLAEEEELARLQHGEQDGTPLCREEGIATWHQHQHQYQHQHLERNDSMEAQKKSRRGSLEWLAGVIKERKGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZX7</accession>
    <name>M2QZX7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_345897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703914.1">
        <property type="nucleotide sequence ID" value="XM_007705724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZX7"/>
    <dbReference type="STRING" id="665912.M2QZX7"/>
    <dbReference type="GeneID" id="19137741"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_345897"/>
    <dbReference type="eggNOG" id="ENOG502S8IT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030750_0_0_1"/>
    <dbReference type="OMA" id="TKTAGWW"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="482" mass="52946" checksum="8A1C5E5DB24952BD" modified="2013-05-01" version="1">MSMQSIYKSESEGVDLDNLLEDYVDTDLLRPFNNSSSAHSSPDVLACLLGIASSNESDLFGAESILNRETKTAWHKPLQECDQSFASPWSDYSASPSYFASPSATESYSDSESLNYQGFIGSVGEQLRSMSQPCTPRPYTSRRSLEKAVAFQNQMKYRGTRKSSETLPTRPSRTMQASHSRPYTPDLWNNQTTPIHIVSRTASEEPSSLATLSELTENENKDSLLVQDYSQVRTLGHSLLPTNDEQYFSHYQSTTSASSSMEEPNRNDHAGNIDLSFSSANTSSAVISALLTPPVSLPLASKPWVPDTTPTLDFDFSASPDLIDTSNTASWWNGESTATTYSATNTLHFSSNTELQGLGITCESTPFNYTALPTHIFPSSFTPSPTSPPHRSHPRLRTRPNTSRPRCSRTSSPHPATSRTTTNRGFVNFTPEDSRKILTGVAPSGSSKTKARREREAAERRRKLSQAAMKAVLEAGGGCRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2R2K2</accession>
    <name>M2R2K2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_231755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702798.1">
        <property type="nucleotide sequence ID" value="XM_007704608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R2K2"/>
    <dbReference type="STRING" id="665912.M2R2K2"/>
    <dbReference type="GeneID" id="19134785"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_231755"/>
    <dbReference type="eggNOG" id="KOG1612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046570_0_0_1"/>
    <dbReference type="OMA" id="INKRWHW"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="38"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD61459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="358" mass="38271" checksum="CE403C7D018C45BC" modified="2013-05-01" version="1">MAPQHALVSFSPVELFFLRRALTQTPPIRRDVTKGPRDFRSMRAEYDVLPTANGSARIALEDGTEALVGVKAEVEKTSQLPTLGEPEDVDMGDGADENKAKGQNAWVDMTVEIPGFREDDALPVFLASMLSESLLASGELKDRLYINRRFHWKLYIDILLLSPPLSYPLAMLSMTSHLALLTTRLPALKSEKDEDPLFDDDWDAAVPLYPKQAGTNKTAPQLGKPPVIILAMAVGANIIFDPAPEELAVADAVLAVACTNSTNSATGARIVSIRTIDPPSHLTPPGVPNSMNTATGGTAPTSTADALTQRELLATSGVWTPPRGGMKRSLIAQVTKMVVENGGVAEEVIGALAAIEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2R369</accession>
    <name>M2R369_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_233770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702940.1">
        <property type="nucleotide sequence ID" value="XM_007704750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R369"/>
    <dbReference type="GeneID" id="19134828"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_233770"/>
    <dbReference type="eggNOG" id="ENOG502T5Y0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613916_0_0_1"/>
    <dbReference type="OMA" id="PQICCEY"/>
    <dbReference type="OrthoDB" id="3691065at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="441" mass="49243" checksum="FFFA1CEA417986B5" modified="2013-05-01" version="1">MYRQLLSKGSNSPPNRYPSPQNRTVRPYTDVVAGYQNQASGSNLQRGYGWTPSPQQQSGQRVHDTQSQRTGHLSATRRLTYAEVARKQTPVASQYNSARPLGASSTLAENLQTWSPPRRGPGTVNRRDYAKDPTEDIMSDPDLLSDERLLLMFTNEGNSEGAREPPPYNSMASGMSMLPTLSRPVLEKLTKDDGPWSTFQLQAMPQTGPGAFQANRTGEATYLAAPGIHNLLDSQGPSQYINYASQHDQPTESRSGYGQARGRPTQNMDHQRAPRQVHSNQHASGGANFRQTNTDLLAWSGDGRSHPSASTTSIHPEYRHCPYCDAQFKGNKDGKGNLARHIRHKHTDRPQICCEYCGQLFKRTDARLKHHRKKHQSFPPPKSNSQKSRQSSTQFQAGTQYEVYSTGSGSFNDFETSQDYNANMEQPYQHADDLRGLADPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8I3</accession>
    <name>M2R8I3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_339381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701460.1">
        <property type="nucleotide sequence ID" value="XM_007703270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R8I3"/>
    <dbReference type="GeneID" id="19137376"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_339381"/>
    <dbReference type="HOGENOM" id="CLU_2170858_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="110" mass="12034" checksum="9A5C63CCD9CDA363" modified="2013-05-01" version="1">MAIFFSLTGRKRTLCFRFRVLEVKGRSVQNACSRWREGGSCAHISLCVCVCVCVCVCRDRAYGRQGQLGGDAGPAMCIVTAVAVAVDVGDPHIRWEGGMIFFHPKVGDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8P3</accession>
    <name>M2R8P3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_200899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701500.1">
        <property type="nucleotide sequence ID" value="XM_007703310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R8P3"/>
    <dbReference type="GeneID" id="19134164"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_200899"/>
    <dbReference type="eggNOG" id="ENOG502S9QE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115518_0_0_1"/>
    <dbReference type="OMA" id="AQCASMQ"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="247" mass="26229" checksum="38631B5C6F273650" modified="2013-05-01" version="1">MNNITSGLTAEAKGNMLANLQIELNSRIEKLRAQCEAQCASMQSRLERRVNRIPVVTRQTTLANLLKASAPVRLITAPAPPTKVTDTTAITTTTTTTAATKKTVGTGTAGRKPRNAVPSAPSSRPASSPEVRIKSTSTNKTINTKAVPTYAKATKTARAKKRSSDELSGEDKENSELPVPKKRTRNVAPKAATEKVEKAEKTTTTGTTRSTRAGSRTKPAGGHVLSPKTNAANVRKPAPAARSVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8T6</accession>
    <name>M2R8T6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_92230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701536.1">
        <property type="nucleotide sequence ID" value="XM_007703346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R8T6"/>
    <dbReference type="STRING" id="665912.M2R8T6"/>
    <dbReference type="GeneID" id="19141437"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92230"/>
    <dbReference type="eggNOG" id="ENOG502QWTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023703_0_0_1"/>
    <dbReference type="OMA" id="PNDKEWM"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09245">
        <property type="entry name" value="BRO1_UmRIM23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD63359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="472" mass="51890" checksum="C518B14F21D46D96" modified="2013-05-01" version="1">MPFPFVLPTTSSISFTEYFNSSTHPSLPNCATTARGVLRDVLKRHKRIPPSSQASNFSTVISALNDYIPYLFALDAGLSGTSCAGEEIDLVLVKELEVEWRSTLGSSIPGREPARVKLKSLDSELCYTLSTLAYVYSLQARAQLHTLYNATLPSPEQRATAIGAAMKHFLEANSIHTYLFNRSGQYSSQPAAVDISTAVLGALAELTMAEATLITVLKDDPYPSVVIEDRNKQSKDWMFRGVEIPKVRAHLFARLCLASAEHAAKAQAMLGRSTKISDDLVKYVDDLRRTAKGKACRFLACDAEAGGKTGEGIAWLRGAKKELGFAALGAEEDKKTSGFSKLKKEWQEKREDRKIEKGVDWGTDAGKFEEGRIVDMLLKKWEKQNDTVGVQLIPPSEPLLASMPSGREYHTTKMFVVPALDEHALVRMRAPPDTSEAFEGNEDDSADEDERDTPAGAFPGTKADYTPSTSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RAT0</accession>
    <name>M2RAT0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_90385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD63974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699899.1">
        <property type="nucleotide sequence ID" value="XM_007701709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RAT0"/>
    <dbReference type="GeneID" id="19141344"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90385"/>
    <dbReference type="eggNOG" id="ENOG502SHN6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032992_1_0_1"/>
    <dbReference type="OMA" id="TRVVHHA"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="1">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="331" mass="37946" checksum="DF5A4177F201D9E2" modified="2013-05-01" version="1" fragment="single">QFERIFVISRPDRTDRRDALTIAASIEGFDFEFFDGVDGSKVPDKAIPTTSDHPRLRDPVIGCWRAYMNVMQEIVRNNIATALILEDDADWDTRLRDQLYNFSIASRSLLCLSHQLDRQNSKCSDRFHTSDSEVNFEDLTWTEYHEGSPYGDGWDLLWVGHSEMNFIPETMNKPKGRIVQVDHTVLERHYLKSVMGPYRDIIQNYPHHTRVTHHAYNGLGTTAYAVSLAGARRVLYQVGLKDLTLPVDNTLRSFCDGTEGRTPHVCVCPQPGFFEQYRPPGPAELWSDIQDYGNDYTAKGFSYNVRRSIQHNLEAILENTGQIVDQWPDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBI7</accession>
    <name>M2RBI7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_190338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700059.1">
        <property type="nucleotide sequence ID" value="XM_007701869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBI7"/>
    <dbReference type="GeneID" id="19133716"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_190338"/>
    <dbReference type="HOGENOM" id="CLU_050551_0_0_1"/>
    <dbReference type="OMA" id="MEGYNAY"/>
    <dbReference type="OrthoDB" id="10333571at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="441" mass="48254" checksum="E69BC3286A8F3E9D" modified="2013-05-01" version="1">MAIRGAMMHASDWHLFSDHGAGGIVKSRHDLIRRMDLPRRVWIYVSGSSNERNSYAQDSRALGYCKKRASNNDKVEQLFLPTLLLFSTLSLADKHTDAVGSTPQSPVILQIPELATMLLCRPGRRPVDVAPKRRLHLSGFRLQTTPADQWYRVNHALSKKSRKKASVADDPLGRVTASSLGCEAGGATPTRRISSCGLDGTLLRKDATLFAYSQPAATAGFSSLGLVQSGSRGPVLVKGLHLHVERVRRITSSQRSGYAGVVSGMANVLGPLPPVHPAPPSIIHPFIQPSIIVFALRSGLVAHATKLSSIQTRIDNDNVTSATKAGCCRVTVHRLVDPAMEGYNAYRSRPSLNLVLVRQANQAHARGYVLLLRYHLAVLFKHAAHQQVCNGDDPSRHFPRPSRVSCRIHEPCQIRLSVSLANRPDALRTSRSASSRLHHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBM8</accession>
    <name>M2RBM8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_142537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700096.1">
        <property type="nucleotide sequence ID" value="XM_007701906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBM8"/>
    <dbReference type="STRING" id="665912.M2RBM8"/>
    <dbReference type="GeneID" id="19131245"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_142537"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="OMA" id="IMFTNFQ"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="38"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD64249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="507" mass="54692" checksum="73FD6854C696F781" modified="2013-05-01" version="1">MASAAEVKPELDRTTEKDVERRGSVARTEKGRWERLWPVIACGAGLFSDGYLNNIIGPVNTMLKTIYPNSYASSSAQANVASITFAGTVVGMLFFGYTSDHFSRKWSLFTSTIIIILFATLGTASYGAGGSPSGLLTALVVYRFFLGIGIGGEYPAGSVGCAESTGELKEGTRNKWFILFTNVQIDLAFFISAIVATVVVLITGENHLRAAWRICLGIGIIPPLSLLYLRLKLQEPEAFQRESLAKAKTPWLLIIKFYWFRLSVVSIIWFIYDFSAYSFGIYATSILANLLGESAPLWKSLAWNILINFFYMPGCLAGAFVADLPSMGPKKTLFIGVTLQGIIGFIMAGCYPWLSKPENVAGFVVVYGVFLALGEFGPGDNIGLVASKTCATGIRGQYYGIAAAVGKIGAFAGSYALDAIQKAAGDDEIAAGRNPFFIASSLAFVAAVLVLLLPHIGQDTIDQEDVKFREYLSANGYDTSKMGLQSVPATSVESDGRVSPVEQTYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RCH4</accession>
    <name>M2RCH4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699868.1">
        <property type="nucleotide sequence ID" value="XM_007701678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RCH4"/>
    <dbReference type="STRING" id="665912.M2RCH4"/>
    <dbReference type="GeneID" id="19138896"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37092"/>
    <dbReference type="eggNOG" id="ENOG502QQ8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="OMA" id="QVMRNAA"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="415" mass="45371" checksum="5787AC9FC82F1123" modified="2013-05-01" version="1">MARQLRREDYTVGWVCALPIELVAAQEMLDEEHENLERDPIDNDENLYALGSIGGHNVAIVCLPAGCIGNNPAAAVAAQMRATFKRIRFGLMVGIGGGVPSKGVDIRLGDVVVSQPDKTFGGVVQYDIGKAKPSGFERTGSLNSPPLMLLSAVRQVQAKELRGQSKLAEHVSKLERISKFQRCKTGPDILFEAAYDHEGEETCSKCNTNRQKDREPRDDGELVVTHYGTIASGNQVMRNAAQRDRVSADLKGVLCFEMEAAGLMNSFPCLVVRGICDYADSHKNKLWQAYAAGTAAAWAKEVLSAIPPAQVEKALTVDKAITQAAIKRHLEDDSTYRSNKRARLLHSTGELDESDDNEDNRTSPDDSEGVSSEYDEDNRTSPDDSEEVSSEYDESGSSEDSEQNDPGSESDGQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RED0</accession>
    <name>M2RED0_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">DUF1264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_160084</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699593.1">
        <property type="nucleotide sequence ID" value="XM_007701403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RED0"/>
    <dbReference type="GeneID" id="19132007"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_160084"/>
    <dbReference type="eggNOG" id="ENOG502QR3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071931_2_1_1"/>
    <dbReference type="OMA" id="RHVEAHH"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26251" checksum="D24D127B974A3E47" modified="2013-05-01" version="1">MDSLPVNNKTAGEAESTYNKTLETGAGATQNFAPVKRVCAHLNAFHAYADDPKRAAVEANHYCAHLNDEVRQCILYDSPEPGARIIGIEYMISPKLYATLPTSEQTLWHSHVFEVKSGMLIMPRPSGIPEAAWELAENREMEEVVQLYGKIYHLWQTDRGDKLPLGPPQLMTSYTAAEQMPDFEARIKERDERFGSDYSRKKGVREYIEVPEIHENADATWAKGGVGHGGASEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2RG33</accession>
    <name>M2RG33_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_308925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698789.1">
        <property type="nucleotide sequence ID" value="XM_007700599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RG33"/>
    <dbReference type="GeneID" id="19136336"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_308925"/>
    <dbReference type="eggNOG" id="ENOG502TBV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1256438_0_0_1"/>
    <dbReference type="OMA" id="NIWSNDT"/>
    <dbReference type="OrthoDB" id="3796623at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="225" mass="27339" checksum="682FB78A8D5B6CA0" modified="2013-05-01" version="1">MSYLHFSHTHARERTPEKEPYNGRPLVRRNTHKRDHSITLSDLDDGHDDYPYPANHKSNKISSALTVRDRPSQLERYNIWSNDTRNNEDDERLYSYDRHRTYRYSDRHHHSDNEDAEDRALRLRISATLDRPSTSYHHSHGSHLWPSETLHHSDRWIDEAWETRERSLSRERTRVRRNSFWGGFEEKERETQDERWSRYHRVSDTKTEEIRPLSGWRRRRIVGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJK6</accession>
    <name>M2RJK6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_282588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696692.1">
        <property type="nucleotide sequence ID" value="XM_007698502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RJK6"/>
    <dbReference type="GeneID" id="19135830"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_282588"/>
    <dbReference type="eggNOG" id="ENOG502SJ7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_0_1_1"/>
    <dbReference type="OMA" id="TNVMHFC"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD66889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="317" mass="34498" checksum="68B18FFBC58190BB" modified="2013-05-01" version="1">MSPALVNDNGNNSTTNIFNKDKSFWNNYNKGRPQPPKSLTDRIFKYHEQHGGGFTTAHDVGAGDGLYAAKLKARFAHVIVSDISASNVELAKRRLGQDGYSYRQARVEDAGSVDDASVDLVFAANVMHFPDQAPAMAAIARQLRPGGTFAAAAFGPARFDDEALQALWERISEQGGQELLDKAGAGEQAKTIAVMARTEGTYNTAPLDTSLFQPGAQRVHLNMHRGGLTGMLPASKTHLNTEPNHTGPDDVDVFEEEAGWEFEMDRAGVREHALSFPFISDQSPAMARLFDELDSMLAPGTSARGRWPAKIILATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2RK06</accession>
    <name>M2RK06_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_351630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696788.1">
        <property type="nucleotide sequence ID" value="XM_007698598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RK06"/>
    <dbReference type="STRING" id="665912.M2RK06"/>
    <dbReference type="GeneID" id="19138103"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_351630"/>
    <dbReference type="HOGENOM" id="CLU_013929_17_1_1"/>
    <dbReference type="OMA" id="INRNPTH"/>
    <dbReference type="OrthoDB" id="3693047at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="121" mass="13907" checksum="A1D2FEA192046537" modified="2013-05-01" version="1">MDSISKAIAAIDSQGPEGQISYREAAKIFGVDRNTLARRHQNKTQSRDDATHQRQLLSPPQESELIKYIQDLTERALPPTRSIIKNYVSVIAEWEPSDSWISRFLRRHRDQLTTKFVTGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSN1</accession>
    <name>M2RSN1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_185916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445658">
        <property type="protein sequence ID" value="EMD58253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706020.1">
        <property type="nucleotide sequence ID" value="XM_007707830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSN1"/>
    <dbReference type="STRING" id="665912.M2RSN1"/>
    <dbReference type="GeneID" id="19133531"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185916"/>
    <dbReference type="HOGENOM" id="CLU_903170_0_0_1"/>
    <dbReference type="OMA" id="CCIKRED"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051794">
        <property type="entry name" value="PG_Endopeptidase_C40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47359:SF3">
        <property type="entry name" value="NLP_P60 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47359">
        <property type="entry name" value="PEPTIDOGLYCAN DL-ENDOPEPTIDASE CWLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024339" description="NlpC/P60 domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="7">
        <location>
            <begin position="116"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="308" mass="33235" checksum="2F3130DA58C4E826" modified="2013-05-01" version="1">MRFIISLLALSVAAKAAVVVPLELRADIKCSTGDGDGICVQDESTCKGSVVDDGCSTAGFSCCVPPDANDTGDDGDNDGGDEGVGPDDGDHIPDDDDNEPAITARDSSPLLVPRKDTCSVKVYKFALKQRGVPYKWGGGDCNGPTRGGFDSSGLTKYAVCQATSKRKVLPHSAWQQYKSRKCKHIKYANRQKGDLVFWSTKSSGRCTKDSSIKHVAVVQNDRYIIVAGKKVKRQRMWSGHGAHSFTASQSYKYHFAIYYLAYGLNSLSWASLSIANTMWVTEAFPQWAAPAVVVVGGRLANNQAIKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXW4</accession>
    <name>M2RXW4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_125993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704194.1">
        <property type="nucleotide sequence ID" value="XM_007706004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXW4"/>
    <dbReference type="GeneID" id="19130646"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_125993"/>
    <dbReference type="eggNOG" id="ENOG502SM5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_22_1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="272"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="60701" checksum="705D4788290C7D0F" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2RY24</accession>
    <name>M2RY24_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_99612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704234.1">
        <property type="nucleotide sequence ID" value="XM_007706044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RY24"/>
    <dbReference type="GeneID" id="19141865"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99612"/>
    <dbReference type="eggNOG" id="ENOG502S7ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089056_0_0_1"/>
    <dbReference type="OMA" id="TTCENGA"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="174" mass="19561" checksum="AC7FC3BB0C8DEB44" modified="2013-05-01" version="1" fragment="single">ISSANTINVGPGQPAQVLHRDLGNYPHYHLLGPDSPETQFTLFIITVVFTNANSASRIIPGSQKWPFDRKWSTDQTILSEIEADNCLLFGGKVVHSTGANTTDYERGCVAFTYCANHLTPEEAHLHILKVNVVRELSERAQRSLGFRSQYPWWAPGLWMDSYNEVAIRLGLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZ74</accession>
    <name>M2RZ74_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_150103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZPS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703718.1">
        <property type="nucleotide sequence ID" value="XM_007705528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZ74"/>
    <dbReference type="STRING" id="665912.M2RZ74"/>
    <dbReference type="GeneID" id="19131526"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_150103"/>
    <dbReference type="eggNOG" id="ENOG502RTN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048223_0_0_1"/>
    <dbReference type="OMA" id="CNATQRR"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11307">
        <property type="entry name" value="M35_Asp_f2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000043">
        <property type="entry name" value="Major allergen Asp F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024508" description="Putative peptidase domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Putative peptidase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="314" mass="33540" checksum="04A41073F7729799" modified="2013-05-01" version="1">MAARVSALLLLGASAVVAGPIAPRDTFTITTSENAQISVGDSTWNAGAVDSFPIHASCNATQHTMLQKGLNEAVILARHARDHILRWGNESHIYTKYFGDSPTGEPIGWYTKIADGDKAGVLFRCDDIDGNCHQDGWAGHWRGSNASSETVICDLSYELRKPLESMCMYGYNVANGATNYFWASDLIHRLLHLPPVGEGVVEHYTNEEEEKYPSVINLAKNNATYSARDSDTIQYFALEAYAYDIAVPGVGCPGRYAAPEESPAATSSATPSATSAAASATASEAAAAPAEACEPHNDHWHCPPGVPEPTSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2S435</accession>
    <name>M2S435_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_122079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702301.1">
        <property type="nucleotide sequence ID" value="XM_007704111.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2S435"/>
    <dbReference type="GeneID" id="19130508"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_122079"/>
    <dbReference type="eggNOG" id="KOG0985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002136_0_0_1"/>
    <dbReference type="OMA" id="HCYDLLH"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000006">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Salamov A."/>
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    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699082.1">
        <property type="nucleotide sequence ID" value="XM_007700892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBK0"/>
    <dbReference type="STRING" id="665912.M2SBK0"/>
    <dbReference type="GeneID" id="19138645"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36043"/>
    <dbReference type="eggNOG" id="ENOG502SNTP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049331_2_0_1"/>
    <dbReference type="OMA" id="IQAQKDT"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="84"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD64668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="306" mass="33997" checksum="15F29BB9EBC6FD8F" modified="2013-05-01" version="1">MPPKSILKKTPTVAANAPPTTAAAAKTVNPRHLAVARHHASVLEDRKRVEAEVLQAVMTLMDFPSSPDADAKRPTPADARFFQTAVISFQPADYDALIEERNIADKCGYALCPRPKSKARSTAKKQFVDTEDGVQIVDRKVLEVWCSDDCARRALYVKVQLSEEPAWLRHGGYGDKIELMVENEEEHRVALPLRPKQPVASTKDQDEADDVDAAWAARENAMADLALERGEKPGQVTKANSDLVQDQILERPLNNAPPQPPSLPTQTSDHTMAIEGHVPRINRKDKDDDKDEDEDDPQDWEKHLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDC7</accession>
    <name>M2SDC7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_35376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698290.1">
        <property type="nucleotide sequence ID" value="XM_007700100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SDC7"/>
    <dbReference type="STRING" id="665912.M2SDC7"/>
    <dbReference type="GeneID" id="19138258"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35376"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_0_2_1"/>
    <dbReference type="OMA" id="MLYFRVE"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="174"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD65313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34846" checksum="5B2F0BE299E8DCFC" modified="2013-05-01" version="1">MSTPSRCLATAAKNFKSSPIATVPQRAFASSTTNALAYSRNATTPKTTCLRELQRIQTSAGKTAGSLGEQARTFSQSASRSKLKTIDQIRARNKGGPFNLTAAILFIAAGGGLWAYFTYEKERLARKRIAEQTKGIGKPKVGGPFQLVDQNGNPFSNEDMLGKYSLVYFGFTHCPDICPDELDKMALMYDKVVAECGNVLLPIMITCDPARDNPKVLKEYLAEFHPDFIGLTGDYEQIKSTCKAYRVYFSTPNNVKPGQDYLVDHSIYFYLMDPEGDFVEAIGRNFTADQAAKVISDHIKDWEKPLKKETRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDK4</accession>
    <name>M2SDK4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_35449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698316.1">
        <property type="nucleotide sequence ID" value="XM_007700126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SDK4"/>
    <dbReference type="STRING" id="665912.M2SDK4"/>
    <dbReference type="GeneID" id="19138304"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35449"/>
    <dbReference type="eggNOG" id="ENOG502S4PT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078856_0_0_1"/>
    <dbReference type="OMA" id="HPTIIMT"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="237" mass="25393" checksum="8A637C99B3DC439E" modified="2013-05-01" version="1">MSNSLPEEVVTCLQNARFLHLATCSENIPHVSLMNYTYLPNTPYSSSPIIIMTTPASSRKTQNLESNSLVSLLVHDWISHRPPTLSQPGRSPSPTRPAPRSGSLAELLLGMNTASLSRISTTINGLAQMVPSGSEEETWYKAQHVANNTFSDGTEDIYSTSPGGEGLWGSSGLGNGAASGDAPREGNAGARCYLDGEEVRVVIVKIRDGRIADWKGQVRDWRLSEGIQGALPNGTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SF35</accession>
    <name>M2SF35_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_39750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703101.1">
        <property type="nucleotide sequence ID" value="XM_007704911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SF35"/>
    <dbReference type="STRING" id="665912.M2SF35"/>
    <dbReference type="GeneID" id="19139561"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39750"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="OMA" id="WRKQGDD"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="13"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD61045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="444" mass="48715" checksum="DE2B37B7817C71A8" modified="2013-05-01" version="1">MAPSTISNIPSSILIVGSGAFGLSTAYSLCQNPQYKDTSITVVDRQPFPAPDGSSIDTSRIIRPDYAAARYTRLATIAQNRWRTDFATEHYHEVGLCVTAWGPEQQYVPNSLANVRAIGTDKVEVLNSAEEIQRACGLEGNAPWGNGSTGYVNWSSGWADAEGAMIWLREKVESLNRVKFVTKPVKKLLINHKTSTVSGVRFNDSSELKADLTVLAAGAWTASLIDLRGICKATGQAICYMPISEEEEAKMANRPTLLNLSHGLFMIPPSKRLLKVARHGHGYINPTTIPHPESDDPNETITVSLPYTGVDDPTQAVPVEGQRQCRDFLKAIHPSIATPSRPFTKSKICWYTDTRNGDFLISYHPKYSGLFVATGGSGHGFKFLPVIGDSIVECLQGRTPEDFKGLWDWPAERIPEKQWPGDGSRGGPVGLVLREEMEKSRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFU5</accession>
    <name>M2SFU5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_122792</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702692.1">
        <property type="nucleotide sequence ID" value="XM_007704502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFU5"/>
    <dbReference type="SMR" id="M2SFU5"/>
    <dbReference type="STRING" id="665912.M2SFU5"/>
    <dbReference type="GeneID" id="19130534"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_122792"/>
    <dbReference type="eggNOG" id="KOG1915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011554_1_0_1"/>
    <dbReference type="OMA" id="HIKVWIS"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="374"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD61310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="81559" checksum="837A2819B00617D7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFX1</accession>
    <name>M2SFX1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_84115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697693.1">
        <property type="nucleotide sequence ID" value="XM_007699503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFX1"/>
    <dbReference type="GeneID" id="19140988"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_84115"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="OMA" id="PPQTHWI"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="30"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD66128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="498" mass="56442" checksum="1476B4750F6E86A6" modified="2013-05-01" version="1">MAPGPDGKRELREWECWDKLAYSWPKWKKAMYLASIAGIQISMNFNTSVYPSAVNPVAEHFGISTQAARVGQMIYLVFYSFGCELWAPWSEEFGRWPILQLSMFLINIWEIPCSVAPNFATIIVCRALGGLSTAGGSVTLGLIADMYEPENQHWPLCFIVLSSTIGTSIGGVIGGPIERYLSWQWNFWIQLIFGVTVQAVHFFMPESRATILIDREAKRRRETGEDPNIYGPNELKKPRISLKEAGKIWLRPFEMFIREPIVLLLSLLSGFSDALIFTFLEAFNVTFPNNFGFGTLQVAWAFIPINASYFFTYFLYWPWFWRDDHLRKKNGPDWMTPERRLKPLLLLALFEPIGLFGFAWTCMGPPQTHWIAPMIFSFLVGLANFAIYYSSVDYMIAAYGPYSASATGGNAFARDFLAGISAMYATPLYHNLADSSPQRSQYATTLLACLSCLIVVPIYVFYWKGPQIRKASKFASILAEDRKAEGVRRLSKADNLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2SH90</accession>
    <name>M2SH90_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nonribosomal peptide synthetase 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Extracellular siderophore synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_54465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702174.1">
        <property type="nucleotide sequence ID" value="XM_007703984.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SH90"/>
    <dbReference type="GeneID" id="19140308"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_54465"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_7_1"/>
    <dbReference type="OMA" id="AFEGTHY"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LCL_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Enniatin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="204"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="1702"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2778"/>
            <end position="2854"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="2869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD61780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2869" mass="318740" checksum="DCBB61D70F0FB45C" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2SH94</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_35072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697568.1">
        <property type="nucleotide sequence ID" value="XM_007699378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SH94"/>
    <dbReference type="GeneID" id="19138039"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35072"/>
    <dbReference type="HOGENOM" id="CLU_2922480_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="61" mass="6831" checksum="4FE8117B460EE15A" modified="2013-05-01" version="1">MSPMCKWQWNWQRVNSNTGHGVCIGFGACKSGGSVECGRGGGGVRGKRARGEEKKVWYRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SI18</accession>
    <name>M2SI18_COCSN</name>
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        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_138963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD66858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698236.1">
        <property type="nucleotide sequence ID" value="XM_007700046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SI18"/>
    <dbReference type="STRING" id="665912.M2SI18"/>
    <dbReference type="GeneID" id="19131109"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_138963"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_5_1_1"/>
    <dbReference type="OMA" id="KNAWWWL"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="75902" checksum="5211E2616ED5B8A0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697302.1">
        <property type="nucleotide sequence ID" value="XM_007699112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKM3"/>
    <dbReference type="GeneID" id="19133188"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_179320"/>
    <dbReference type="eggNOG" id="ENOG502QVGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007933_1_0_1"/>
    <dbReference type="OMA" id="SSARWDY"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025083" evidence="1">
        <location>
            <begin position="22"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="2">
        <location>
            <begin position="755"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="848" mass="91431" checksum="62056AD211434C21" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SL72</accession>
    <name>M2SL72_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_359205</name>
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    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701292.1">
        <property type="nucleotide sequence ID" value="XM_007703102.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SL72"/>
    <dbReference type="GeneID" id="19138608"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_359205"/>
    <dbReference type="eggNOG" id="KOG3182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070703_0_0_1"/>
    <dbReference type="OMA" id="DHREKDG"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ChaC"/>
    </dbReference>
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        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD63025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="265" mass="29399" checksum="942C50A682A85720" modified="2013-05-01" version="1">MTTEHEKEIESFGANNDFWIFGYGSLIWKPPPHYDQRLPGYIEGYVRRFWQVHHRGTPEAPGRVVTLIDRAHWETLGDQHDAPSRVWGAAYHIPARYVESVRKYLDLREINGYSIQFTPFHPAVSSATAAPEEVPAEDSSSLPSTAIKVTSTESLVPEPECIKCLVYIGLPENPQFLGAQDPDALARKILQSKGPSGENREYLYNLDVALLGLSEDSGDAHVSDLVGRCRALEEEIGTGGGNEGEKSGQVLHKVGSTEEQEEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLP1</accession>
    <name>M2SLP1_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_73962</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445760">
        <property type="protein sequence ID" value="EMD58071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706228.1">
        <property type="nucleotide sequence ID" value="XM_007708038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLP1"/>
    <dbReference type="GeneID" id="19140509"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_73962"/>
    <dbReference type="HOGENOM" id="CLU_183171_1_0_1"/>
    <dbReference type="OMA" id="AKYGIYD"/>
    <dbReference type="OrthoDB" id="3762113at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6602" checksum="CA45D022C6BB0FDC" modified="2013-05-01" version="1" fragment="single">KAKYGIYDEDVYNFDEAGFMIGKITTQLVVTASERRGRPKAVEPGNREWVTLIAAINAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLU9</accession>
    <name>M2SLU9_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_38139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701085.1">
        <property type="nucleotide sequence ID" value="XM_007702895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLU9"/>
    <dbReference type="STRING" id="665912.M2SLU9"/>
    <dbReference type="GeneID" id="19139179"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38139"/>
    <dbReference type="eggNOG" id="ENOG502SAMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029947_3_0_1"/>
    <dbReference type="OMA" id="RENAVMH"/>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="2">
        <location>
            <begin position="11"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="462" mass="52315" checksum="839135536CF54072" modified="2013-05-01" version="1">MGGDVDYQICSRDIQRHSSNLFIDKEADCTAEVWNLGFSSLESQRNSRGIKKPIISLVRNLQDLENQWKGLDDSSTITMIVIRRKNSWSRMKILPEMFNYIIASVGTPPQFLKIVLGLGQRTSSGYESFTTFYRSFMTPVGSEPNVVANGFDISYNIRYFEPHGRQLQDPYSCRQSGIHHKFYFQGSRSTWIIIQPPQLFNEDLQQTDSQDKSHPLALHVRLIKSATYYFKEYLSFKASQLGLMDAKLSISKPYAEFDTDFSTSQALHLLKKQLLLALEVVDGVSRITQKLLIHLCDPRTFSNVLSQINMKLDLGQISSDMEGHKATIRHLLQVVESIGALNRDILALRNQELLVQNSHVLSQLAQASANESKSITAMTNKTQQDSRVMRIATVIAMVYLPANLVLSFFSTSLVELRTTTQAESTSARIMVFDQVWVAVVSSFLLVIFNIAALIVWNRLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLW5</accession>
    <name>M2SLW5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_269574</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695842.1">
        <property type="nucleotide sequence ID" value="XM_007697652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="19135583"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_269574"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OMA" id="RTSMRHD"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="774"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1198"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1230"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1273"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1320"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1471"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="152"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="853"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1500"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1138"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1506"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1530"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD68158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1561" mass="175581" checksum="C6D98DD2DCAECC9B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMH7</accession>
    <name>M2SMH7_COCSN</name>
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        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_42010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD58346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705966.1">
        <property type="nucleotide sequence ID" value="XM_007707776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMH7"/>
    <dbReference type="GeneID" id="19140141"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_42010"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_3_1"/>
    <dbReference type="OMA" id="FANSICD"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD58346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="432" mass="48149" checksum="BD946474856F9A96" modified="2013-05-01" version="1">MSRVAVTPVWGQLDPLATLPVCAQKCLASSFANSICDPLKDMSCRCNNGTQQLIAINCFSTSCTARETLTTLNVTTVMCEVPVRDRSGLYRTVNSVLFTLSTVAILGRFYSHFALGRLQLLDDGNMALILVLNILMFTLTTMMSFTGLGQDIWKVSFKNIRLTLLYFWISVPFYGIEFGLGKIAFGLFYLRIFNDSGFRKLVWFVIVFTLLYTIAFAFLGTFVCSPVSYFWWQWDLGGEHKGKCLNNNTIGFVTASFSIFTDLVMLGLPIPQIWALHLSTKKKVGVLFMFSIGFLVTIVSIIRLHALVNFAKSTNFTYDFLDTSLWSLIEIYVGIICVCMPSLKLGIQFFCPKILHSVMSTSRYTGSGRTGGNIAIHRSVQVTIGSYPTKPQTEEQGSTVELVEIVGDAKSTPIHERSQCETNNVEQGYLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMT5</accession>
    <name>M2SMT5_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_45201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697445.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19140202"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_45201"/>
    <dbReference type="eggNOG" id="ENOG502T0BC">
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    <dbReference type="OrthoDB" id="3794732at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14392" checksum="1C0045084D0DE6D0" modified="2013-05-01" version="1" fragment="single">VHTEVLISTSDFLKNVMKLEWRADKNCPIDFSKEDPKVVETYCRWLYSGKISCCENPWTTSKITCQLFILGEKLVDQTFKNAVLDFMIENFSSKPKVLPNDKSVKIIYDGTPKGSPARRLVVDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNX1</accession>
    <name>M2SNX1_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_279441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705908.1">
        <property type="nucleotide sequence ID" value="XM_007707718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNX1"/>
    <dbReference type="GeneID" id="19135779"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_279441"/>
    <dbReference type="HOGENOM" id="CLU_2196739_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="108" mass="12547" checksum="6F8D680F8E42EFF9" modified="2013-05-01" version="1">MKMKNPKPSSPLHPPSHLPQHHPTPVPYPRIHGYLHTDSWYRNRFLRDPVRAIRTLPCDWLRVCRQDLEEPPPPSPSHWGSIGGRCTHAYVNTTFEGKPVSSKRWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP99</accession>
    <name>M2SP99_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_264020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="5">Belongs to the SAT4 family.</text>
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        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
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        <property type="entry name" value="Fung_rhodopsin"/>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="388" mass="44076" checksum="3FC0B67B65ACEABC" modified="2013-05-01" version="1">MQIMGNHALIYGASGISGWAIVNAILNGYPSKEAFSKVTAMVNRPLTREMALWPEDPRLQIVSGVDLVKGTQEELEAQMKEKVKDVETVTQVYFYSYKQIDDPDSECKVNEAMLERAVTTIDHLSPKLSYVVLPTGTKIYGCQMLDKFPFTKDLPLKETLPPIPEPYLSQLFYYNQIDCLKRISEGKKWNWCEVRPDNIIGFVPNNNAYCLAQTLALYLSLYRFIEGEGAKCPFPGSEKSWVNKYNESAQDMVAHFSIHASLHPEKTASQSFNVGGQEDSWSGKWPVICDYFGLEGTGPEEGSPQPGAYIDAHKQQWQELEKKHDLKPGSADSDITHPGFQYYIMTMFDFDRQMSMEASHKVGYTEEIRTKEAWTIAFDRMRKAKVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPP1</accession>
    <name>M2SPP1_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_349069</name>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19137936"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_349069"/>
    <dbReference type="eggNOG" id="ENOG502S5DD">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
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    </dbReference>
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        <property type="entry name" value="MGH1-like_GH"/>
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    </dbReference>
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        <property type="entry name" value="Six-hairpin glycosidases"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025662" description="F5/8 type C domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="502"/>
            <end position="664"/>
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    </feature>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50022"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    <sequence length="664" mass="73780" checksum="96ED851A69604C5C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR33</accession>
    <name>M2SR33_COCSN</name>
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        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 85 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_194025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_007706812.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SR33"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_194025"/>
    <dbReference type="eggNOG" id="KOG2331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274528_0_0_1"/>
    <dbReference type="OMA" id="TECTHLA"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHH_sf"/>
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        <property type="entry name" value="ENGase"/>
    </dbReference>
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        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="104"/>
            <end position="416"/>
        </location>
    </feature>
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        <location>
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            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1135"/>
        </location>
    </feature>
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        <location>
            <begin position="1114"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1148" mass="127626" checksum="A6768DAC4D3EF8F3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS61</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_160085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65100.1"/>
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        <property type="nucleotide sequence ID" value="XM_007701404.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19132008"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_160085"/>
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    <dbReference type="HOGENOM" id="CLU_081361_0_0_1"/>
    <dbReference type="OMA" id="QKPRIHR"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
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    <dbReference type="PANTHER" id="PTHR38489">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489:SF1">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
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            <end position="95"/>
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        <location>
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        </location>
    </feature>
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            <end position="24"/>
        </location>
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        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
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            <end position="65"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="203" mass="21987" checksum="E28CD77B7AD70454" modified="2013-05-01" version="1">MSSQSALASTNAIGDTVTNASDYGTSDTDSTLSESSEEPSSDESSSEEEDDDDENDDGEDTEMELDEAKGTDGVVNLRANRGTKPIMKLTKAEMGPDIRGFLKDFLPRLKAANEELEAQKRAGTLRRLDAEDQQEGEPYIEMDLGLGVLEEKDPNAAESDTEGTSDAEEEDDNKEKDVLGKLLGRREKPDPAKIEVLPNTTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSX4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_249579</name>
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    <dbReference type="HOGENOM" id="CLU_039854_1_0_1"/>
    <dbReference type="OMA" id="FFNAWMS"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="69"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="413" mass="45878" checksum="08352DA8E00DFB88" modified="2013-05-01" version="1">MAPVEVLMVGTGEYTTGFVGGGASKSDKKVGVVGLTLFDLRRRGKVGKLSMVGTSGGKFPAIREHLQKNISEAYNNLDVSFEEFPKEGKTDPNAYKAAIDALPKGSAITIFTPDTTHYPIALYAIERGIHVLITKPAVKLLEHHQKLLETAKKHNVFVYIEHHKRYDPAYADARFRAQKLGDFNYFYSYMSQPKSQLETFKAWAGVDSDISYYLNSHHIDINESMIPGWKPVRVMASAAKGIATSLGCDPATEDTITLLTNWVKKDDPNKVGTGVYTAGWAAPQKAGVHSNQYFHYMASTGEIRVNQAKRGYDVTDDETGLLWYNPFYMKYAPDEEGNFAGQIGYGYISFEKFIDAVNKLNAGEITLEELDARPLPTLKNTIATTAILEAGRRSLDENRPIDIIEENGVWSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2STX6</accession>
    <name>M2STX6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_346806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704411.1">
        <property type="nucleotide sequence ID" value="XM_007706221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STX6"/>
    <dbReference type="GeneID" id="19137798"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_346806"/>
    <dbReference type="HOGENOM" id="CLU_1740372_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="150" mass="17114" checksum="645E5F825CF8658A" modified="2013-05-01" version="1">MGAIYQISAWYSESSLENLRRLLQELKVEAERWARLKAPADDDGGDGGVAEDMVGEDEDDMVDGDNMVDKDNENMVKEDDEEDTMHCVYLNTDTEATLYHTKICSHEPMRNFELQYNPVFLYIHANTAQITMTIILTTTSIFSPLPRLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU13</accession>
    <name>M2SU13_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_35811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698402.1">
        <property type="nucleotide sequence ID" value="XM_007700212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SU13"/>
    <dbReference type="STRING" id="665912.M2SU13"/>
    <dbReference type="GeneID" id="19138536"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35811"/>
    <dbReference type="eggNOG" id="KOG2511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030991_0_0_1"/>
    <dbReference type="OMA" id="IEHCLEY"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="181"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="341"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD65785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="487" mass="54114" checksum="5B4BC3E2A34727E1" modified="2013-05-01" version="1">MAAEPATLPEGIFSLLDTDLYKLTMQCCILKFFPDVAVTYGFTNRTPDKKLSRAAFKWLQAQVNKLENVSVSDEELKFLKDSCPYLNAQYLHFLSTFRLKPSKQLRLSFTPVNDTSSDSDYGDFHIHTEGLWLDTILYEIPLLALVSEAYFKFVETDWNHDGQVEKAYQKGKALLEGGCIFSEFGSRRRRDYHTQDLVLQGLRRAADEGAKLGWKGKLSGTSNVHFAMKHGLVPIGTVAHEWFMGVAAITNNYEKANEIALEYWTATFGAGVLSIALTDTFGTPAFLRAFKEHIPRITTAVPGGSTTLASSENTTTSDAVETLASTNPPVQAPYDGDAASEKTYAQVFNGVRQDSGDPLEFIKMMRDFYDKEGIKDKKTIVFSDSLNLELCFKYKAAAEEQGFQPTFGVGTFLTNDFVEISTGKKSVPLNIVIKIASAQGRHAVKISDNIGKNTGDQATVHEVKQRLGYQEKSWVGGDERTRWGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUK9</accession>
    <name>M2SUK9_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_163186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="120" mass="13806" checksum="55499D814B784FF3" modified="2013-05-01" version="1">MNLGGREWVTFIAGINAAGWSIPPFLIFTGKHYLSAWYEEAEIPRDWVIVVSDNGWTNNELGVAWIKHFDAHTKTRVPLDVGCFSPLKRAYSREVESLIRYHINHITKLEFLPAFKVAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUW3</accession>
    <name>M2SUW3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_29171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007704842.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SUW3"/>
    <dbReference type="GeneID" id="19136009"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_29171"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019028_0_0_1"/>
    <dbReference type="OMA" id="PISFYRV"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041823">
        <property type="entry name" value="YHR202W_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026148" evidence="2">
        <location>
            <begin position="18"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="366"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="624" mass="70260" checksum="A2B7E6D5A4CFD5A1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SV40</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    <sequence length="245" mass="26889" checksum="5EAC59567E664A97" modified="2013-05-01" version="1">MASSSEPSCSRGLNSYPDPWCAVYSNVATDPSGMKDINHHSKNEANPKNEVIPTPNRITEFFCQADGTCRMPTVKPLGPDPSIWPSTPPPPDQWSSSNTKCSIAWPDLSTFLPVPQGPIEPPTSKYRLKTREQEEPCEKLGSAVLLEGSIPYFGTGCGEYGRKIDTNAICRFFDKNRMRRQQCAKEDTPLIFSSVLPPSTRQAAAPSRQPDSPLMVCAYPAPPQPVTPSASRYETYSHALASRPS</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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            <begin position="1"/>
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        <location>
            <begin position="58"/>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703366.1">
        <property type="nucleotide sequence ID" value="XM_007705176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SW07"/>
    <dbReference type="GeneID" id="19133826"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_192829"/>
    <dbReference type="eggNOG" id="ENOG502RJAP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2120678_0_0_1"/>
    <dbReference type="OMA" id="GTYAPRM"/>
    <dbReference type="OrthoDB" id="3692146at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="117" mass="12985" checksum="3BA4E78FE0DD6E34" modified="2013-05-01" version="1">MNLGSWDGISTMSIVFVAIGGVIAVLSLIILAATIMGIPNRRRRQDDKGNFSSEEMERDSIDFELLEKDIIEVTVTRMPSTSHSSPSHGTYAPRMPSIPVCEWFTRDRSVPKSLQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXL8</accession>
    <name>M2SXL8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_39373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702636.1">
        <property type="nucleotide sequence ID" value="XM_007704446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXL8"/>
    <dbReference type="STRING" id="665912.M2SXL8"/>
    <dbReference type="GeneID" id="19139484"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39373"/>
    <dbReference type="eggNOG" id="KOG1560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044094_1_0_1"/>
    <dbReference type="OMA" id="WYQSTYF"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="364" mass="40787" checksum="F526D0C5E061572D" modified="2013-05-01" version="1">MADTQKDVLFKTVQIDALVAIKIATASGKSFPSIATGSIVGMEKNNVLEITNSFPFPDVSPAQADGQNETAANLAAAAPRAKQNIAYSNEMIKFLREVNVDANNVGWYTSTSMGNFVNLNTIENQYFYQSQPNERTVALVYDVSRSSQGTLNLRAYRLSPSFVTAYKEGKFTTESLQKSGLRYHDILVELPVTIHNSHLLTSLLHQLPASAPKEELKFPPNLAALQQDPNIPQPPLFPNYDSLDLSIDPFLEKTCDLLLESIENHHTEINNYQYYQRSLAREQAKITAWQQKRKAENAARTASKQSLLPEDEWQRLFKLPQEPSRLETLLNSRQVEQYSRQVDGFTAGVTSKMFAVKSNLLPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZJ5</accession>
    <name>M2SZJ5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_229104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ND90Pr</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702490.1">
        <property type="nucleotide sequence ID" value="XM_007704300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZJ5"/>
    <dbReference type="STRING" id="665912.M2SZJ5"/>
    <dbReference type="GeneID" id="19134738"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_229104"/>
    <dbReference type="eggNOG" id="ENOG502SCN3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_464581_0_0_1"/>
    <dbReference type="OMA" id="SVCSWGC"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="587" mass="66965" checksum="91AD56F9426FC0C9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZK7</accession>
    <name>M2SZK7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_81579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697320.1">
        <property type="nucleotide sequence ID" value="XM_007699130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZK7"/>
    <dbReference type="STRING" id="665912.M2SZK7"/>
    <dbReference type="GeneID" id="19140840"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_81579"/>
    <dbReference type="eggNOG" id="KOG2022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005271_0_0_1"/>
    <dbReference type="OMA" id="CLASIGK"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD67745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113991" checksum="786E7CF724C1F9E1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZW6</accession>
    <name>M2SZW6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_82186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697407.1">
        <property type="nucleotide sequence ID" value="XM_007699217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZW6"/>
    <dbReference type="STRING" id="665912.M2SZW6"/>
    <dbReference type="GeneID" id="19140877"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82186"/>
    <dbReference type="eggNOG" id="KOG2950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024456_1_0_1"/>
    <dbReference type="OMA" id="GENTNFY"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="386"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="441" mass="49333" checksum="FC71F60EBBC6A0A9" modified="2013-05-01" version="1">MASSSGTYNPARPKRAGEQFTRTHHLDKDEPSTKKPRFDPRNPSTLAPDADDDEEDPALEADVIGKGSGIKRNAVNIDGYDSDSSTENFDIRAEANHKKEKPAKDDDDDDDMFADEPKEDEQDEELGQDQGKKKKLRFLDNAEIEGQEESSKSGGHVAVDFTKGGKATADEVESSSDEGDDEERDRLDSDMDEELGAGSKKKHAPKLDAFNMRAEQEEGRFDEAGNYVRKAFDPDAVQDSWLEGISKKDMKKAKEAQDKRDAERKAKERAEDAIVTSDVLSTLISHLEVGETPMEALVRYGKAVPKKATNNWAKKKKKAQSMEVDTDPSEEAAAAKAKQVIDSITECASRLSDRGVEDIYELPRESIMRQYKRETGEDWKNLNAEPVQWEFHWLNAPEGDINGPYDQATMQAWEANGQFAAGAEFRRVGESEWSRLLDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZZ8</accession>
    <name>M2SZZ8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_156374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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    <sequence length="324" mass="35892" checksum="9FABF54947D159C1" modified="2013-05-01" version="1">MASQSSLKVILGTHMIGDTSKDPGTVRFDKDEDIQALLDAFHSRGYTHLDTARDYSPGDQGASESRLGRVNAVSRFNVHTKVHSANPGDHEPAKLEFSISQSLHDLQAPSVETMFLHFPDRQTPFEDTAKAMNNAIQQGKFRNFGLSNYSATEVERFLTICEERGYAKPSVYEGHYNAIARGCEKELFPLLRKHSMSFYCYSPAAGGLFSEHSETSGRWQEDNFIGRPYNIMYRKPPVHAAVATILELAKEHGMNGHASAIRWTAFHSNLDGTYGDGIIFGVSSVGQLNKTLDALEAGPLPPELAEAITEVYEIVEGAEPLYYL</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <source>
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        <source>
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    <sequence length="560" mass="54093" checksum="C0B91AF5DFC70803" modified="2013-05-01" version="1"> </sequence>
</entry>
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    <accession>M2T1M2</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
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    </reference>
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        <text evidence="6">Component of the mitochondrial small ribosomal subunit.</text>
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    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="255"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="255" mass="29175" checksum="6EC66B3921087FBF" modified="2013-05-01" version="1">MGRYDFRPLRVRQTAKALFDAKRNPELPQWYDVIGNIPPGETLARPVLRVPKMRKARKASKLFKPLPIAYPEDKLRSEFFGDHPWELARPRLVVEDSGNDSKNYDWSKIVQPGKQLDGESVVQRQMWLMKNASLSKASAYDVARREFYKHRHLSEIRSRIAKEEALHVGAYFGKGPLEIGMELEDRQWENWKAWATKQIEDEQAMRAQMFSGQQDDGAGTDMSSNEYDQAIEELQPAAPNNPQGQRPLGGVAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1V5</accession>
    <name>M2T1V5_COCSN</name>
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        <recommendedName>
            <fullName evidence="6">Superkiller protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_33389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1V5"/>
    <dbReference type="STRING" id="665912.M2T1V5"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_33389"/>
    <dbReference type="eggNOG" id="KOG1127">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001688_2_0_1"/>
    <dbReference type="OMA" id="AWHCVET"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
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        <property type="match status" value="11"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="708"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="742"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="921"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1143" mass="126261" checksum="5480D5D14F2AFCC6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3H2</accession>
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        <recommendedName>
            <fullName evidence="3">Protein-arginine deiminase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_31756</name>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007695915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3H2"/>
    <dbReference type="GeneID" id="19136512"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31756"/>
    <dbReference type="eggNOG" id="ENOG502QVJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015851_0_0_1"/>
    <dbReference type="OMA" id="SNAFREC"/>
    <dbReference type="OrthoDB" id="5102063at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004303">
        <property type="entry name" value="PAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013530">
        <property type="entry name" value="PAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036556">
        <property type="entry name" value="PAD_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837">
        <property type="entry name" value="PEPTIDYLARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837:SF8">
        <property type="entry name" value="PROTEIN-ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03068">
        <property type="entry name" value="PAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF110083">
        <property type="entry name" value="Peptidylarginine deiminase Pad4, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026368" description="Protein-arginine deiminase C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Protein-arginine deiminase C-terminal" evidence="3">
        <location>
            <begin position="210"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="711" mass="76713" checksum="C06653B1B7F8E112" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5D0</accession>
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        <recommendedName>
            <fullName evidence="4 5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_195395</name>
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    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694887.1">
        <property type="nucleotide sequence ID" value="XM_007696697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5D0"/>
    <dbReference type="STRING" id="665912.M2T5D0"/>
    <dbReference type="GeneID" id="19133936"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_195395"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_1_1"/>
    <dbReference type="OMA" id="IYWIWQA"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026432" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="402" mass="44717" checksum="82BB26596D8B5582" modified="2013-05-01" version="1">MRLFHALASCQLLATGLVAAVPLDSQPASTINIDPTVEPLEALAQLQQHAYETLRQRESVSKRDSTGCSLATATIRKGWQVLHIQFKKDRKAYIEAVQCLRRLPPRSDPSWAPAAKNRFDDFVAIHVNQTLFIHGNGPFLTWHRYFVWAYEQALRNECGYKGYQPYWDWFAHADNIYESPVFDGSDTSLGGDGEFFAHNGSLAGGRLIPIPSGLGGGCVKSGPFKNTQANIGPISPGMQGLTDLATGITDYNPRCLRRDLSPYIPKKWFTTKNLLNVTIGAGSVTHPIFWQEIQGRYTDGFLGLHASGHYTMGGDATDLYSSVNDPAFFLHHTMLDRIYWIWQVLHPAEANKVAGTLTLQNKPPTRNATIDEPLEMGINGETLKIRDMFDTLGGTPLCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5I4</accession>
    <name>M2T5I4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_36842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699804.1">
        <property type="nucleotide sequence ID" value="XM_007701614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5I4"/>
    <dbReference type="STRING" id="665912.M2T5I4"/>
    <dbReference type="GeneID" id="19138832"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36842"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008535_0_0_1"/>
    <dbReference type="OMA" id="HATVCVD"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="351"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="588"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="804"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD64267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="922" mass="101802" checksum="B82CBF64235B4199" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">COCSADRAFT_88338</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="XM_007701331.1"/>
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    <dbReference type="eggNOG" id="KOG3080">
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    </dbReference>
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        <property type="term" value="P:ribosomal large subunit biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="170" mass="18098" checksum="1EFAD362C7FED327" modified="2013-05-01" version="1">MGSGVAKEHVQGPPGPLSRAQWQCWRLSPPMTLSQTPLPTSKHIEGIHDGPRLDATASPFGQQSFHSARRGKEAPSSQMGDMSTALLVHTYWGSPHLAHSAGSFAPCLVNQLAISPRPSPSATPRLLPGGLPCLDSSTLLRFRPFSVSQIETCSLLKIVSSVRAMSVSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T841</accession>
    <name>M2T841_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_139339</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698569.1">
        <property type="nucleotide sequence ID" value="XM_007700379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T841"/>
    <dbReference type="STRING" id="665912.M2T841"/>
    <dbReference type="GeneID" id="19131119"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_139339"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045961_0_0_1"/>
    <dbReference type="OMA" id="KINHTKG"/>
    <dbReference type="OrthoDB" id="2379805at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08153">
        <property type="entry name" value="srpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024168">
        <property type="entry name" value="Catalase_SrpA-type_pred"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000296">
        <property type="entry name" value="SrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="2">
        <location>
            <begin position="2"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="333" mass="36584" checksum="35121FA5946004CE" modified="2013-05-01" version="1">MPLSTDTQVLETSNGLVSTLRGMAGDAAQSFRPAHAKGHLLTGTFKPTTSAAELTSAPHFNAASTPITVRFSSSTGFPKIPDTDANANPRGIAIRFHLPEQNGKRQHTDIIAHSTKYFPTRTGAEFLEFLKAATSSNAAEAVPEFLSRHPETARFLQDSKPSPESFATEKFFGVNAFRFVKQDKVTTLRYRIVPVAGEQHVDVEALKSKSDTYLFDELTPRLEKAPVEFKLLAQIAEEGDVTDDATQIWPEERKVVELGKITIEKTLGEEESLEKQRNVIFDPIPRVQGVEPSDDPLLEVRANVYLISGKQRREAEPVKSEVGKPTDAAVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8Y0</accession>
    <name>M2T8Y0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_87070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698560.1">
        <property type="nucleotide sequence ID" value="XM_007700370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8Y0"/>
    <dbReference type="GeneID" id="19141158"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_87070"/>
    <dbReference type="eggNOG" id="ENOG502SXGW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_572358_0_0_1"/>
    <dbReference type="OMA" id="QAFTIWR"/>
    <dbReference type="OrthoDB" id="5397734at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="478" mass="54139" checksum="C3CBFAFFD360CA35" modified="2013-05-01" version="1">MSGSSNHATSASFLQDLSNLQSLVALRRIERAPSHLWDEDQRELLTILYRWYDNADQTTLPRVFNYVTGLDLRISVVRYQFENHVLLYGGRAFSEYARVMAIPFHDPEGRYNAIRGIIEETATDSGIDLQRRETEIAFDSGAARWAKSPRTRKTYRSLVRRAAQKEKEKGQISRLTEPVVLPSDQQEIPISECVLGNVALSTNNQDEERWSDTENPSPRTALVEQVRSSMEPIKRKIAFRVWDENSRTIFSKEDGFVSQAFTIWRGEYPPPFTPDGEGRDALKLLTNLHLCLKGGASTFVSLSTSLLQALVKASTMDDPWIAIERMVWASVPAGAILHHFPIADLHILAQRDPICSQLLNLSAFQPRRRTRHVSDRMCEQLNTITTHTIRAVAAIARAFGMHCERVSHVHIQGFIAALVDSFQLRYDETGDAHASNIAHNFAVTLRSRVHRIEDVALAFLEGARQGNDVVAYYARRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAN5</accession>
    <name>M2TAN5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_355382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698969.1">
        <property type="nucleotide sequence ID" value="XM_007700779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAN5"/>
    <dbReference type="GeneID" id="19138362"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355382"/>
    <dbReference type="HOGENOM" id="CLU_046000_0_0_1"/>
    <dbReference type="OMA" id="WHRKEAP"/>
    <dbReference type="OrthoDB" id="3687805at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="473" mass="52578" checksum="8947EF9AACC41A0F" modified="2013-05-01" version="1">MVLHNLLSKEGVSALAYTADDASVPWLCLLRIVKSHTDTQLGLYLEYPLPRPGIDDKQRVFLRYEGDNLVPGTISLTKLDISLPATLLTDLGRNGSHQTRTLSLTLKQPCSVWHRKEAPSVCPDFPKLLKLARARQIRIVFDTNWLGTNYSRFQCIFNGSKEFARVPILPNFTNLYRQVEWSILSLLQDVSPGADTPIDGARAGEHIAQDMTTQDPPPYQQEPGSVKRSRDNGLSPVPDTPATKRSRHPPDSPLLDCSTPTSQVSSTSTVPVNLFQEAVASEVKKALPGLLADFFGGMRTGHSSSSRSSPTPPYTRISNAPTRYDRTPNRRLTPITEMERTITSALTQTFAQDIDRAFEHASEHASELYNSASIEIEEIVANARSDLAMISEDQKFGFNEYCSQQVDDFEQRVAEGKEEAEAEIRDVFLTASENFDTAKQAARANYRQNALNNGRRAISLPLVKEDEDGITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2TB01</accession>
    <name>M2TB01_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_137996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <name evidence="5" type="ORF">COCSADRAFT_85462</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_85462"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="LVWTYWT"/>
    <dbReference type="OrthoDB" id="69964at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Mug62_dom"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Meiotically up-regulated gene 62 protein-like alpha-beta" evidence="4">
        <location>
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            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="862"/>
            <end position="994"/>
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    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="1337"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1570"/>
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            <begin position="1515"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1677"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1722"/>
            <end position="1731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24919"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66222.1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">ND90Pr / ATCC 201652</strain>
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    </reference>
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        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
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    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD66626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="66" mass="7564" checksum="B8D42EAFA8CC6567" modified="2013-05-01" version="1">MSGMLGTVYNAVLRSNTTMLFTVFGAAFGLQLAFDTSSDKIWDRVNRGRQWKDIKHRYMEAAEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCL4</accession>
    <name>M2TCL4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_179802</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698016.1">
        <property type="nucleotide sequence ID" value="XM_007699826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCL4"/>
    <dbReference type="STRING" id="665912.M2TCL4"/>
    <dbReference type="GeneID" id="19133218"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_179802"/>
    <dbReference type="eggNOG" id="KOG3758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011361_3_0_1"/>
    <dbReference type="OMA" id="HSCLDFF"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="89"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="233"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD66552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="724" mass="80313" checksum="2AE0D10E00F5F947" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCN9</accession>
    <name>M2TCN9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_35086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697570.1">
        <property type="nucleotide sequence ID" value="XM_007699380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCN9"/>
    <dbReference type="STRING" id="665912.M2TCN9"/>
    <dbReference type="GeneID" id="19138055"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35086"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018784_0_0_1"/>
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    <dbReference type="OrthoDB" id="515064at2759"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="102" mass="11662" checksum="D799D6A8E954E20D" modified="2013-05-01" version="1">MTRHCQGGSHVTSPPYPGAWLPISYRPCCPIFCATLHSTGLYWVGGCDRLLLPLYLALVSNQYCEKCRMLTWYYTKGGQFALHPTLDNSCHKCANIWLLWTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2TE61</accession>
    <name>M2TE61_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_352488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697163.1">
        <property type="nucleotide sequence ID" value="XM_007698973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TE61"/>
    <dbReference type="GeneID" id="19138158"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352488"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794553_0_0_1"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026675" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="349" mass="37842" checksum="D6E0A3D4F87AF07A" modified="2013-05-01" version="1">MAIRHIFIAASLALAFAKTNAENPASGKYGYTTAYDYIIVASLENYPDLKALCDDTPDLSGCVLGGSTVINSMNYINPSRDDFDAVWPKGWQWDDIQASAAKLYKRNPGIINPSVDGRCYDSIVYDVLSKELAQAGYNSVNTVTNPNDKKRIYGHSAVNVMNGLRSGPVRTYLPLAQCHKIMVQTHCFSRRNNQIDIVYQVTFGTITVGSMGMNAAGKAIYTKSALLQTAADKEALTIELDNWLAMSRTPGSRLVYSGGANTNGAEIIKTNGIGTGYHLTSSTIMGTDNGTKGGKSVVDTNYKVYGIDNLFVVDLRIHPKVPSGDTMVITMIATEHAVTKILELGNKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2TE88</accession>
    <name>M2TE88_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_50000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696666.1">
        <property type="nucleotide sequence ID" value="XM_007698476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TE88"/>
    <dbReference type="GeneID" id="19140269"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_50000"/>
    <dbReference type="eggNOG" id="ENOG502SYSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135732_1_0_1"/>
    <dbReference type="OMA" id="ANSCTWS"/>
    <dbReference type="OrthoDB" id="4788795at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="78" mass="8515" checksum="4502EA3088C81CE9" modified="2013-05-01" version="1" fragment="single">VHKWRVTADNVYGISGWCGGLWDNMKSFQGDCPISDAWCGGENGLLEWKFTTPSTCGPGAVEAAWWEATKNEFGAIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF74</accession>
    <name>M2TF74_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_81765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697065.1">
        <property type="nucleotide sequence ID" value="XM_007698875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TF74"/>
    <dbReference type="STRING" id="665912.M2TF74"/>
    <dbReference type="GeneID" id="19140854"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_81765"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_2_0_1"/>
    <dbReference type="OMA" id="GFFMDTT"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="9"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="354" mass="39436" checksum="2C42294CDEE52F4A" modified="2013-05-01" version="1">MSHPLPRRIDVHSHFLPPFYRTALAENGHSNPDGMPAIPEWSLERHLEMMATANVSRSVLSISSPGTHIVPGKNALGRDLTRQCNHYAAQLKKQHPDKFGVWAALPLPDVEGALVEIETCISEGAEGFGLMTNYHGNYVGEKALDRVFDKLNQIGATVFIHPTKPCIKHGNATSPAQTTDALPFGDQYPVPIFEFFFDTARAVINLFSTGTVDRCPNVKFVIPHSGGALPPLMTRFIQFSSVVPGGRVLKHSTVRRQLETQFYFDLAGFAFDGESGGNGQLKAFVEGFNISHEQLLYGSDFPFTQTQFVKSFADRMKDGLENLFNEEQRNAIYEDNAVKLLEEGNHARMRFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFR0</accession>
    <name>M2TFR0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_34367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696600.1">
        <property type="nucleotide sequence ID" value="XM_007698410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFR0"/>
    <dbReference type="STRING" id="665912.M2TFR0"/>
    <dbReference type="GeneID" id="19137613"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34367"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="65"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="292"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40714" checksum="C56ED39492FBC471" modified="2013-05-01" version="1">MVNITEKIKEIEEEMRRTQKNKATEYHLGLLKGKLARLRAQLLEPAAGAGGGGGSGFDVSKSGDARIALVGFPSVGKSTFLSRITKTKSEAASYAFTTLTAIPGVLEYGGAEIQVLDLPGIIEGAAEGKGRGRQVISAAKTSDLICMVLDATKKAEQRRLLEAELEAVGIRLNRSPPNIYLKPKKAGGMKISFQVPPKYIDEKMVYNILKDYKMLNCEVLVRDENVTVDDFIDTIMKDHRKYIKCLYVYNKIDSIGLPHLDELAREPNTVVMSCELDLGIQDVVDRCWEELRLIRIYTKRKGCDPDFSEALIVRQGSTIEDVCDQVHRTLKETFKHALVWGASARHVPQKVGLGHVVADEDVVSIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGD5</accession>
    <name>M2TGD5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_271368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695951.1">
        <property type="nucleotide sequence ID" value="XM_007697761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGD5"/>
    <dbReference type="GeneID" id="19135622"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_271368"/>
    <dbReference type="eggNOG" id="KOG4306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024751_0_0_1"/>
    <dbReference type="OMA" id="PKQHQCY"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52349" checksum="A9352AF940E34BBD" modified="2013-05-01" version="1">MPSKGVKCFAYIAADGVEIEFTVPKQSVRRNAQREFLFDHLEIESSNLPRFKFTGNFEFIVRRDGRELTKQWVRVNSMTGKVEDGTMVNMEQTPALFPEDVVITYGFYDAGPGLAELPKQHQCYVTVTPNYENWMCDKIPQDSDLANRPFHKMVLPSAHDIGMNNMASSLSLIKNAGTGLIREVLGRSLPRALSILNKVSDGAINHIAPDIIRALAITQKDTLDAILKIGARYFEFRPAKCHRQLHSLSDLDDTLYFQHGAIPGMPYRVLLDHITRFLAAHPDEIIVVHNRWDGVPDACPRPNASDLTDTLSPLLADKNLAIGTQDDMQHKSIRDLRNEQKRLIILTDLPQYSNYDDEANATLTGDSMLARLHSMCDGPPADANAPVTLFQCQATATNIRDVIVATVLDNNVSTSPILATKPVCDAKILPLLKGDVGRKLVREREGVVVFVNDFFDGATADVAVGACVERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGN6</accession>
    <name>M2TGN6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_272519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696020.1">
        <property type="nucleotide sequence ID" value="XM_007697830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGN6"/>
    <dbReference type="GeneID" id="19135639"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_272519"/>
    <dbReference type="HOGENOM" id="CLU_2454589_0_0_1"/>
    <dbReference type="OMA" id="GKFELCC"/>
    <dbReference type="OrthoDB" id="3683803at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="89" mass="10050" checksum="74067ED149F95B3A" modified="2013-05-01" version="1">MRVQLVDKSAVHRSLIRIRGGGKFELCCPVPQTRPLQSNSPPFTDERTATSSRSQLYHVHADSGTNLSRLVEQSYLRYKPSKNVPRTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TH04</accession>
    <name>M2TH04_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_80386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695734.1">
        <property type="nucleotide sequence ID" value="XM_007697544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TH04"/>
    <dbReference type="MEROPS" id="S10.016"/>
    <dbReference type="GeneID" id="19140788"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80386"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="OMA" id="IWHMLQG"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF404">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="654" mass="70967" checksum="8CE2E9281A1D0776" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2TH27</accession>
    <name>M2TH27_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_350137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="65"/>
            <end position="89"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="109"/>
            <end position="128"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="459" mass="52044" checksum="31506806D2EBABCA" modified="2013-05-01" version="1">MVDRLSKYNLIDASVSTLPRRMSTNLNDPHVRPTNRRMHHGSIAMTAVPHSFSLKGVLSRWEKRWFSALAILLSSMLSLSTGSLLGLLGSMVRWPLLARKLYTPVDADLILGVSNPTGAVKLIWIHTVQKRKWCVTTVIVMVYLLADIIGRISVAAFGLTFDLNEEPRIEYPTKLTNWGTSDWFNDYVLERYRGEEIMSSNTSVVHSSSRCFWGTVSLRENQERVVDYGDVIYEATFENIVKKIMSVYTELLTTIWRLSLRDNILLESSYSTTYNVSNLLHRAGHDERMWKGIEEDDSTYGVRVYSGIGSGEHFAKSLTTRLPLLAVLGADIQLPKVTQISGASERLFIDVRLNVKLKEPITVLMCIFGGQVLAIAVAIFYCRKVFIRDYASSLSIARLLKTTMEEVEGMSTCTGEKLMEYLDRKGVMMRYGTRRKGDEALEVDLWNDVEDEFPDAIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI34</accession>
    <name>M2TI34_COCSN</name>
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            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="10" type="ORF">COCSADRAFT_108806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695992.1">
        <property type="nucleotide sequence ID" value="XM_007697802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TI34"/>
    <dbReference type="STRING" id="665912.M2TI34"/>
    <dbReference type="GeneID" id="19130070"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_108806"/>
    <dbReference type="eggNOG" id="ENOG502R1HB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004096_0_0_1"/>
    <dbReference type="OMA" id="LYVYINA"/>
    <dbReference type="OrthoDB" id="5322661at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD68367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1047" mass="115589" checksum="2B33326C64EBFC73" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIR3</accession>
    <name>M2TIR3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_206167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694523.1">
        <property type="nucleotide sequence ID" value="XM_007696333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIR3"/>
    <dbReference type="GeneID" id="19134322"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_206167"/>
    <dbReference type="HOGENOM" id="CLU_2440694_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026541" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9950" checksum="3989A565EC6E77F9" modified="2013-05-01" version="1">MQTLSWLLLVLAPWRQVVTTGCGTPRSTPETSSVIRANPPKNDSAGFRNQSILTVNGTAQGSSLCARIRLDRNRLMSLLEVLGKLYRTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJJ0</accession>
    <name>M2TJJ0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_277545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696366.1">
        <property type="nucleotide sequence ID" value="XM_007698176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJJ0"/>
    <dbReference type="STRING" id="665912.M2TJJ0"/>
    <dbReference type="GeneID" id="19135747"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_277545"/>
    <dbReference type="eggNOG" id="ENOG502SR3R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034747_0_0_1"/>
    <dbReference type="OMA" id="CCMCGYW"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD68867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="252" mass="27301" checksum="8EE2983EF914631E" modified="2013-05-01" version="1">MPHVEVLPNSATTVAPGWTYVVDTGYDPSKVAINPKNKKRAAAATPGGQRGENELSARQQTAIARRIAELERDNDPKQAIAVPGKPGVPKTQNARRIIQYQRQIKHWLDDEEAQLGLMATASRATAQPSRKQSIYASVPATPIEPVPAPQAIAQTSSRLDDTNADDDDALLSIDRAMPPPLNPEDMEVLLAAPPLSYAASHVAAPPARAPPQRQFCDNCGYWGQIKCRKCGARVCGLDCKDAHEATRCLKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJT7</accession>
    <name>M2TJT7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_341369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694761.1">
        <property type="nucleotide sequence ID" value="XM_007696571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJT7"/>
    <dbReference type="GeneID" id="19137475"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_341369"/>
    <dbReference type="HOGENOM" id="CLU_144281_0_0_1"/>
    <dbReference type="OMA" id="DEIPGQC"/>
    <dbReference type="OrthoDB" id="3692499at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="153" mass="16533" checksum="5852D8B47C09E2CD" modified="2013-05-01" version="1">MATSLRGAMRACVGSSIKRLFSLPWSGLVLLRRSNVVVLAAVPQSYRRAGDAKEKVPHGEKDTTASGVVKISTPTHLFFSAPSREPLHTDDEIPGQCPFPHSRWRRRRAHLDCLAQYGVLGCPDTVTSTVHPPTTTAHALLALLGPYQGPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK59</accession>
    <name>M2TK59_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_76422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694850.1">
        <property type="nucleotide sequence ID" value="XM_007696660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TK59"/>
    <dbReference type="STRING" id="665912.M2TK59"/>
    <dbReference type="GeneID" id="19140564"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_76422"/>
    <dbReference type="eggNOG" id="KOG1964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005882_1_0_1"/>
    <dbReference type="OMA" id="RYQGFCK"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1029" mass="116511" checksum="80AEED64F6B71D3B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKW4</accession>
    <name>M2TKW4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_155935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695010.1">
        <property type="nucleotide sequence ID" value="XM_007696820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKW4"/>
    <dbReference type="STRING" id="665912.M2TKW4"/>
    <dbReference type="GeneID" id="19131726"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155935"/>
    <dbReference type="eggNOG" id="KOG0778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354866_0_0_1"/>
    <dbReference type="OMA" id="NGDPRAW"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="580"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="789" mass="87150" checksum="E3AA60B6153D8C89" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLM0</accession>
    <name>M2TLM0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_78281</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="KB445637">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696668.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2TLM0"/>
    <dbReference type="GeneID" id="19140656"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_78281"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002761_1_0_1"/>
    <dbReference type="OMA" id="FCILEQF"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine carboxyl methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000043">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="865"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="710"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD69572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117887" checksum="5606F5BA9C8F74FA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLU7</accession>
    <name>M2TLU7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_342279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695268.1">
        <property type="nucleotide sequence ID" value="XM_007697078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLU7"/>
    <dbReference type="GeneID" id="19137533"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_342279"/>
    <dbReference type="HOGENOM" id="CLU_1454259_0_0_1"/>
    <dbReference type="OrthoDB" id="10376521at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD70141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="186" mass="19961" checksum="EC42A564A82EDBD6" modified="2013-05-01" version="1">MANPHVDAGSVNSAIPGGPSLTVQMHTPVPSLTSEVGNWSIYSPNSPNVFDFSTPAAIGGENPTIAGSETVSTFDNIFGLDLVSSHDMVTVDPVLACDPLSSASETQGKSTEGKDCDRTPLCSPPLPWIRRWYTADLAADHTVRISEAKALSIPSNTLTECILEHYMQTWRDPHTRGASSDRMYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2TM46</accession>
    <name>M2TM46_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_78204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695015.1">
        <property type="nucleotide sequence ID" value="XM_007696825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TM46"/>
    <dbReference type="STRING" id="665912.M2TM46"/>
    <dbReference type="GeneID" id="19140650"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_78204"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_1_2_1"/>
    <dbReference type="OMA" id="MCCVYGP"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="45"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD69792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="327" mass="34598" checksum="955D43CEF6CC901A" modified="2013-05-01" version="1">MAMNIDRRRNNAPSGGTSAPVFARTIREPQYVEKLRPTRSRGPNELRRIFLQTSIIPSASGSAYLEIPSSSVANSSSLIAPTSSLKITASIQGPKPLPRSAPFSPSLLLTTTVKFAPFATRHRRGYLRDATERDLGVHLETALRGVIIGERWPKSGVEVVVTILEGDEDGWWGDLASGGSATGSGWGLLNVLAGCITVASAAITDAGIDCVDVVCGGVAAIVRNPSSKNEQELARILDPCPAEHKEVVAACVVGYLASRDEITEMWMKGDVGAEPDALIEGATHAAVGSLAVVKEVLLEAVQAKFQKQIEGSESGVKRKAQDVDMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TN60</accession>
    <name>M2TN60_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_217313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695254.1">
        <property type="nucleotide sequence ID" value="XM_007697064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TN60"/>
    <dbReference type="STRING" id="665912.M2TN60"/>
    <dbReference type="GeneID" id="19134521"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_217313"/>
    <dbReference type="eggNOG" id="KOG3414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117348_0_0_1"/>
    <dbReference type="OMA" id="GMYELYD"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD70122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="143" mass="16796" checksum="32CFB9CB17B7E271" modified="2013-05-01" version="1">MGSVVLPHLRTGWHVDQAILSEEDRLVLIRFGRDSDPDCMSQDEVLYKIADRVKNFCAIYLCDLDEVPDFKAMYELYDPCTVMFFFRNKHMMCDFGTGNNNKLNWVLEDKQEFIDIIETVYRGAKKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2QV45</accession>
    <name>M2QV45_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF3328 domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_102733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705455.1">
        <property type="nucleotide sequence ID" value="XM_007707265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QV45"/>
    <dbReference type="GeneID" id="19129814"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102733"/>
    <dbReference type="eggNOG" id="ENOG502SRM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_4_0_1"/>
    <dbReference type="OMA" id="AIMCFGD"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="29082" checksum="99DD85C34B174061" modified="2013-05-01" version="1">MSPFRYSKVSSESSQDSSLENQRIPPRRNRCCSIFEKLEFLRWPVTFFLLFTILLCELSMLQNRPKAVLVGTDFNSIVPVFSTEKKIFRSDKRFRSDHKTMESVNKTKKEWTNLLPLGAGFMEVSEYTSHTLPPPMHFPEAPGKEVFSLAVFHELHCLMHIAASMDDLVMQIRRKDFELDESFLLHNDHCFDYIRNAIMCFGDTTLEGQTRTPGLEHVPGTDGTGAIHVCRNFDEVSAYAEEKRLNEGREHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2QVB6</accession>
    <name>M2QVB6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_194440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705488.1">
        <property type="nucleotide sequence ID" value="XM_007707298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QVB6"/>
    <dbReference type="GeneID" id="19133895"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_194440"/>
    <dbReference type="HOGENOM" id="CLU_438041_0_0_1"/>
    <dbReference type="OMA" id="HEIHTGF"/>
    <dbReference type="OrthoDB" id="3694330at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="581" mass="63970" checksum="047A6D5A2341ACA5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2QVI3</accession>
    <name>M2QVI3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leptomycin B resistance protein pmd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_165319</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705517.1">
        <property type="nucleotide sequence ID" value="XM_007707327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QVI3"/>
    <dbReference type="GeneID" id="19132376"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_165319"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OMA" id="VNGWIQM"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000240">
        <property type="entry name" value="ABC transporter B family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
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            <begin position="85"/>
            <end position="163"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="152"/>
        </location>
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        <location>
            <begin position="392"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="EMD60229.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="463" mass="52240" checksum="1386306D37AA6667" modified="2013-05-01" version="1">MADEYGYSESCRSWHDHPPRMVWVYLHQDEKWVALPPTCVHPCDFEDAPSRQPKDAIIMDESTFRKKHIASWTQETGTVAEKGNHSVVPAHDDSAQPQDVKEPLQKVEASEPMQNQIASKDASPARATRATDATTMLNKPVSTQTSPMSTKPKSPEQPKPAHSAPELKLWALDSRKNLGRQDPQIPYYKLKEFAPKVIQYTEIPPEWRQTFGRLRNDPLINPSKIGLDGKAVNGRWCFKQLLTDQVCDNPNCLGSHVPPNRKQFFFILSLHAKDPRTKADLNRNFCYNILKVYYRKHFLKGTTPVLTPRWTGTRLTAYPKLLRKPFYRGAEVPENMFSGTIIDRILDEWDELYTAQEKMSLREELLLPCSIPTTTEAQGNTEVSPFRNKQPMPTPPATVPPETAPQQGNTPSTPSIVSNTPASDVVAKVLPLTEENLAVVQGVLRRRNWGSTDSELVESIAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZ99</accession>
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    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_242124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703745.1">
        <property type="nucleotide sequence ID" value="XM_007705555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZ99"/>
    <dbReference type="GeneID" id="19135032"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_242124"/>
    <dbReference type="eggNOG" id="ENOG502RS2J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036324_0_0_1"/>
    <dbReference type="OMA" id="NNEIRWA"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="429" mass="49427" checksum="82108B103E447AF9" modified="2013-05-01" version="1">MHFSPSRIVIGFAIFIAFSFIYTINSVSARDPTSVFFDPNKGYTPRYSALRRQQAEAFVSAYNPATVVKAGPERQRKLCVGIPSFKREGTQYLPDAVGSLLEGLTPEERKEIYLIVFIPHSRPEIHPAYNEAWLPGLADEVLTYGYGFDRMQYIRNLETQHKIDEKGIFDYRYLLDKCREQYTPYIALFEDDTVAVDGWYHRTIAAIDEAERKAALQRAKPDFLYLRLFYTEEFLGWNAEEWSTYLKNSLYVALIPTAIFIFIRCFQPTTKFSLTVVTRRTLVATYAVLAIIILLFFAFGRITVQPMPPGVHEMPAFGCCGQAYVFPNVKATEIVEYFKDRHLGYIDVLLEDLANERHELRYAITPSLVQHVGRTNSHHDDGLMSKWGLSVAERIWSFAFEKFDWRALRQEHEIVANLRRQATVGTTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2R050</accession>
    <name>M2R050_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_184439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703981.1">
        <property type="nucleotide sequence ID" value="XM_007705791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R050"/>
    <dbReference type="STRING" id="665912.M2R050"/>
    <dbReference type="GeneID" id="19133461"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_184439"/>
    <dbReference type="eggNOG" id="KOG3200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059836_0_0_1"/>
    <dbReference type="OMA" id="KSPKTKW"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="100"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD60694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="274" mass="29831" checksum="AB1BF759077DC5CE" modified="2013-05-01" version="1">MTGSEYSNAKLDLEAFRIVSLPPDFYYIPNFISVEEETSILQKIPAQRWTQLSHRRLQAVPSTLTKNNTLLASPLPVYLTTPIIDRFKDLGIFDHTPHQQPNHVLVNEYKPGQGIMPHEDGDAYAPVVATVSLGAPLCLDILPKPSVSTGDDDDVDTSKHAQESHDEAKNPPTPTPNITALPTRIFQEPRSLLVTMGSAYRHVMHGIAERETDEGLDGASVANWDLLGDKVVLETMGGTSSRGVRVSLTYRDVLKVSAAASKVLGGLGGSRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2R0E1</accession>
    <name>M2R0E1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_148932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R0E1"/>
    <dbReference type="GeneID" id="19131468"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_148932"/>
    <dbReference type="eggNOG" id="ENOG502SNCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_4_0_1"/>
    <dbReference type="OMA" id="TINHMKW"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="276" mass="31492" checksum="E30CC0448945FE39" modified="2013-05-01" version="1">MEFATNDTSKRHQPYDALHNVVDGSDSSTEVGDEWDTENAAQPRRRRKTVWRRVRRYRWMIDTTLLLVIVGLLAEKRWQKYEKGHLYELAGDITGFAPTFGQQIVSFKPNTVFAPEEPTDFWSKETQHAWLSIVPEGLGYVEVKNASEYSNLPHPIHDYPNQTVFTTSVTHQLHCLYTILEAYNTMKLTVASPASVDPIKKPWHINHCFEYIRQAIMCAGDVALEGAATSFPGGEHGQDLGGSDGWDAKHVCKDYGQVYEYLERETINHMKWISSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2R339</accession>
    <name>M2R339_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_95972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702917.1">
        <property type="nucleotide sequence ID" value="XM_007704727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R339"/>
    <dbReference type="GeneID" id="19141650"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95972"/>
    <dbReference type="eggNOG" id="ENOG502QQ5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_3_2_1"/>
    <dbReference type="OMA" id="AYCTDAF"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF3">
        <property type="entry name" value="PURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD61619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="65643" checksum="D7A770E831C23488" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2R4F2</accession>
    <name>M2R4F2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_38855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702128.1">
        <property type="nucleotide sequence ID" value="XM_007703938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R4F2"/>
    <dbReference type="STRING" id="665912.M2R4F2"/>
    <dbReference type="GeneID" id="19139355"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38855"/>
    <dbReference type="eggNOG" id="ENOG502RZY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033338_1_0_1"/>
    <dbReference type="OMA" id="AWGKSAM"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="6">
        <location>
            <begin position="206"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD62054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="471" mass="54932" checksum="B30502FE434E1060" modified="2013-05-01" version="1">MAAPKPGGFKMSLGALKAKPGLKASPAQKDNKKPKALLDDDEPDDAVKQQEITGWDAAEGGAVDANGKKEKEQLRVIPVPPNRDWRAAARRKHLAKAPHQQAQNETVDEKQIEEPKYQYGLTVMKKDDAQEDGSAESDTPEPMEVEQDNLTEQERLEKKALEALITGKSTDNDLVIPVQTEEEAFQHDLQNAPEAPTLEAYEATPIEGFGAALLRGMGWKDGEGIGKNGTFVKPKEIKRRPALLGIGAKEDAAVGIELGEWGGGKGKGKGKKVAQSYNPVTLRNKHTGEIITEEELKAKLENQKLVEEEKASKPKSKYDDDSEDERRREKRRDKRDDRDRDRRREDNYDSEQRRDKDRRREKDDYYDSDRRRDKRKERTRDDDHHHHHHDSERRREKRRDRSRSPDDRKDKRRDRNRYRSRSRDSKSKSDRRDRSRSRDSDDRRRRRRERDYEDDERYERKKKYRDDGYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2R4L0</accession>
    <name>M2R4L0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_122401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702407.1">
        <property type="nucleotide sequence ID" value="XM_007704217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R4L0"/>
    <dbReference type="STRING" id="665912.M2R4L0"/>
    <dbReference type="GeneID" id="19130521"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_122401"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="HELCFPP"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="517"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD62084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="69112" checksum="12598C606D5F595F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2R5E6</accession>
    <name>M2R5E6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_220303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701778.1">
        <property type="nucleotide sequence ID" value="XM_007703588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R5E6"/>
    <dbReference type="STRING" id="665912.M2R5E6"/>
    <dbReference type="GeneID" id="19134572"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_220303"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_6_1_1"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="405"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD62394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="769" mass="88970" checksum="2CF43DC2A719A031" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M2R5J6</accession>
    <name>M2R5J6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">COCSADRAFT_182748</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701816.1">
        <property type="nucleotide sequence ID" value="XM_007703626.1"/>
    </dbReference>
    <dbReference type="SMR" id="M2R5J6"/>
    <dbReference type="STRING" id="665912.M2R5J6"/>
    <dbReference type="GeneID" id="19133376"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182748"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_0_2_1"/>
    <dbReference type="OMA" id="LEMHHQI"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000019">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0009">Actin-binding</keyword>
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    <keyword evidence="10 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="915"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1186"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1584"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1611"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1639"/>
            <end position="1664"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="938"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="23">
        <location>
            <begin position="1782"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="18">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMD62449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1842" mass="205288" checksum="B7D2A58FB57EA119" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2R6F1</accession>
    <name>M2R6F1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3'(2'),5'-bisphosphate nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_223755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inositol_monoP_metal-BS"/>
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        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD62719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="41836" checksum="428F03E39EB2883D" modified="2013-05-01" version="1">MAYTAELRLALRAVHRASVLTKSVLRNLSNNVSAETKADDSPVTIADFAAQALLISALHAVYPHDAFLGEESADALRQNEALADRVWQLVQQAKEEADARLDANGKDEEATASTAAAHDLKEDPVLAFPASKDDMFDLIDRGGNGQVTGSGRVWVMDPVDGTATFMRGQQYAVCLCLLVDGVQQVGVIACPNLAFPLQGTLGSIRINEDDVDSDGYGVVLSAVKGQGTFLRTMEASGPGAHARHVDLTTLPSKQTSDLNFVEATIGKTSLSQTEHEAVATALGASWPGTVLWSQQMKYVALTLGATDVMVRIPKTLDRFTCIWDHAGGHLLFQEAGGIISDFRGEQIDFSAGRKIKGERNWGMIACMPAVFDQVGTAVKHVLNQRDGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8S5</accession>
    <name>M2R8S5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_161853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="19132131"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_161853"/>
    <dbReference type="eggNOG" id="ENOG502RGVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000016934">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="327" mass="35364" checksum="E7E0D159373F6A01" modified="2013-05-01" version="1">MAQRQMYASMGALRRSLGADVASVQACSSRALHSSARRLEEQPSDASPAQPPNSRRVRSATALKQIASLQYRRQPGALARGSFPSGQMLQRTPRSPTTQANEYGFIPEDSAPANTQQDASARAARNTAGPRTTRGSAPPQGQMVRAPSTLRMSRPAPGGATRGPNLRGRDARRPATGGKRSTAGNNRGEAGPKRREKTSGGDETMSTKLADVELGDTISDAMTQQLLRLQRKEWDRVPYEPKYAKGSFAANELIHAGRELFKGESPPVKIWGPLEKRIGVVGMFGAEARLKVRRVLDGDAEPFGQEVIEEAEPVEVKGVEKKETVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">COCSADRAFT_37623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700470.1">
        <property type="nucleotide sequence ID" value="XM_007702280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RAG3"/>
    <dbReference type="GeneID" id="19139030"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37623"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OMA" id="GNWKDYQ"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36136" checksum="553075AC18F1A789" modified="2013-05-01" version="1">MDTIKKAIGSAFDPNTDIPDLSGKVYVVTGGSAGIGYGIVAHLLQHNPAKIYLLSNKEDHADEAQEALKEWGDVSKVEWCKCNLEDLKQVDEVAKSLAKELDRLDALICNAGLGVGVYNETRDGLDSHMQVNVFSQAHLTLVLLPILQKTSDSRIVHQSSDLHRGADSSMKFESIDEINQDIGATKLYNRTKLAQILFLRELYSHIKAGDFGEVTNSLGLPWINATHPGGVVTDQQNQAIEAYGTLGKVGVSAVRPFMKDPVAEGCRPALFAAASPDIVKDQIQNSYIVPDKKVQAPSNQALDEKLQANVWKLTKEVLESKLGSLPYEMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2RCW3</accession>
    <name>M2RCW3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_115471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699251.1">
        <property type="nucleotide sequence ID" value="XM_007701061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RCW3"/>
    <dbReference type="GeneID" id="19130283"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_115471"/>
    <dbReference type="eggNOG" id="ENOG502SHDK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003476_0_0_1"/>
    <dbReference type="OMA" id="GLWWDQL"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1223" mass="136660" checksum="013694702D35031D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RGM4</accession>
    <name>M2RGM4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribophorin II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_115131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698930.1">
        <property type="nucleotide sequence ID" value="XM_007700740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RGM4"/>
    <dbReference type="STRING" id="665912.M2RGM4"/>
    <dbReference type="GeneID" id="19130272"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_115131"/>
    <dbReference type="eggNOG" id="KOG2447">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051361_0_0_1"/>
    <dbReference type="OMA" id="VFFMYYT"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044288142" description="Ribophorin II C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD65904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="289" mass="30220" checksum="4DEF5A5144B26957" modified="2013-05-01" version="1">MRVLHSFVSSLLLSSAAIVSAASSWSFEDATVSVTSKGAGVGGGSKDSLSPSKPLGKSVSLGATDTLKLVLTTVDGGTAKRPHQAYLTLTDPVTGVEDSFVFSVKDSGKGKVDLSHKDLPHQFLTAEKPIAASIVIGSLGSSKPYKSKVFDLNVTRDTSIPLSVPNPPVRFAAEPEIHHIFRDDPKSPPKVITLVFAAAVAAALPILLGAWAILGANASHLGKALGNAPVSHALFYGSILAMEGIFFLYYTTWNLFQTLPAAAAVGIVAFLSGSRALSEVQERRLAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2RH47</accession>
    <name>M2RH47_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_137300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697648.1">
        <property type="nucleotide sequence ID" value="XM_007699458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RH47"/>
    <dbReference type="STRING" id="665912.M2RH47"/>
    <dbReference type="ESTHER" id="cocsn-m2rh47">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="19131046"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137300"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OMA" id="LHWPLYN"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140137" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="32"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD66054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="578" mass="62615" checksum="77EF2BCB49638C37" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RI34</accession>
    <name>M2RI34_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_169357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="entry name" value="AK17A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
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        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 17A"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="494" mass="56338" checksum="862E8658353871AA" modified="2013-05-01" version="1">MCRFTIATLECGHPQEDHVDTYGCPYFQRSNLHCDRDNPNNKDRFTIKTWDREGICNRCLSVARKREEEAIEREQKKYDEQRRREAKEREEELRRGEREVLERGHRQEEERLTEKKRREEAQRAHERQKWASEERTREVERKSKEEYERQIQLQMDKDMEYMMAKSREEAERREREEEEEIQRALAESARLIRSERSYQEDQMSSGSREQGGGRIESWIESTSRTTTTTTMNNHSSSNSSGNNHSNSYNNNHHNNNSSHNNNNSSYPQKSSSPPSPPATPPTRKATSPPPPPPLPVTAPRSPVNKSAARAPPPPPPAPKPAAQAKEINYSLPAVGDQKIGRFRLGSRAVPVHESQDIPETPITPAKPIAPTTPAPMVRLGGAIPVSDVPIVREIKGQIKPVPSAMENARPALPLRKPSVSRKGPPPPVPNRDGRDPQLDAMLAKRRAWEPEEEEGATITPPRSPSKGQTPPAKRMTQNEFDTKRKMGWKNNEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJS0</accession>
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            <fullName evidence="2">G-patch domain-containing protein</fullName>
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    <organism evidence="3 4">
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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    <dbReference type="STRING" id="665912.M2RJS0"/>
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        <property type="term" value="C:kinetochore"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="308" mass="35493" checksum="D3FEC49949DD9BF6" modified="2013-05-01" version="1">MAQSDDEDDYMNMVFDDAPKGPKYETSLQRAARKRKEGEARARQKTKAEREEEAEAAREAALATALPETNKGFKMMAKFGFKQGDALGKSEDARKEPIRVNLKDDRGGIGLESEKKRKFREQFEEADRLAKRAKEEEGDYLDVMRQEQKEKKAERDLDNAQRTAERLADREAEAKGASDTSEKPLKDINVLWRARARRRVEAKRDKQQRRELNDSIASRLPTLAPENEDDDSKIAQGKDLAPFYTTLENELEDEDPELAEFEALPVAERLQKLLLFLRDKYRYCLYCGYEYPDPEMDGCPGVTEEDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RM72</accession>
    <name>M2RM72_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_34514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696632.1">
        <property type="nucleotide sequence ID" value="XM_007698442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RM72"/>
    <dbReference type="STRING" id="665912.M2RM72"/>
    <dbReference type="GeneID" id="19137692"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34514"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009854_1_1_1"/>
    <dbReference type="OMA" id="VKILCWD"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07566">
        <property type="entry name" value="ScNTA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="305" mass="33584" checksum="ACEB2AF1CD696AB2" modified="2013-05-01" version="1">MKVACLQFAPEVGELQDNIQRAESILKATQIPADLAWLILPELAFSGYNFHSLEEIKPFLEPTTAGISTQWAQQTAKHYNCHVTVGYPEITIPSRNPADVQTQYNSIVTVSPSGEVINNYRKSFLYYTDETWASEGPGSKSHNLSNPASPDSPFFAGELGELGNITLGICMDINPYKFIAPWTDYEFASKALSFQSPIICVSMAWLCHLSPTELATDPSQPDVATVAYWVERFQPLVEDKGGRPVCVILANRCGMEKGLCYAGSSTVLRIDKGVVSLYNTAGKSEETCLVVDLADRPKFQVRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSB6</accession>
    <name>M2RSB6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_195283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694793.1">
        <property type="nucleotide sequence ID" value="XM_007696603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSB6"/>
    <dbReference type="GeneID" id="19133933"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_195283"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OMA" id="YLKYVMD"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF63">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="533" mass="59852" checksum="38C6EFE6D5F40B70" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RX50</accession>
    <name>M2RX50_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Concentrative nucleoside transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_40788</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704488.1">
        <property type="nucleotide sequence ID" value="XM_007706298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RX50"/>
    <dbReference type="STRING" id="665912.M2RX50"/>
    <dbReference type="GeneID" id="19139835"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40788"/>
    <dbReference type="eggNOG" id="KOG3747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016813_1_1_1"/>
    <dbReference type="OMA" id="IVWHTVI"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="236"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="317"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="421"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD59618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="72039" checksum="BE4F54663529734F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZQ8</accession>
    <name>M2RZQ8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_243860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703850.1">
        <property type="nucleotide sequence ID" value="XM_007705660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZQ8"/>
    <dbReference type="STRING" id="665912.M2RZQ8"/>
    <dbReference type="GeneID" id="19135064"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_243860"/>
    <dbReference type="eggNOG" id="ENOG502QUI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006123_1_0_1"/>
    <dbReference type="OMA" id="HMMIDPL"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702496.1">
        <property type="nucleotide sequence ID" value="XM_007704306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S4W5"/>
    <dbReference type="GeneID" id="19134198"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_201701"/>
    <dbReference type="eggNOG" id="ENOG502SH73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007091_1_1_1"/>
    <dbReference type="OMA" id="FDMLQDM"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD62208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="835" mass="92988" checksum="C229E5873493BDBF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2S677</accession>
    <name>M2S677_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_93923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701954.1">
        <property type="nucleotide sequence ID" value="XM_007703764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S677"/>
    <dbReference type="GeneID" id="19141534"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_93923"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="OMA" id="EKGHVPH"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD62628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="294" mass="31449" checksum="D84C11D3C0BCA9D1" modified="2013-05-01" version="1">MPAKASTHDLHVAKLFSIKDYVCVVTGGGSGIGLMAAQALAANGAKVYITGRRQEALETAAKSHNPDEGGQIIPLSPCDVTKKDDLERMYQELASKEKYINLLVASAGVSGEKAIPDAEKATDMKKKLFDNETFEGWADTYTTDVTAVYFSTVVLLPLLQAGTEIHGHLSASVIVISSMSGIIKDAQGHFSYNAAKGGTVHLSKLMSAEFQKLRIRVNSIAPGYFPSEMTAKESDEQQKSDLPDEKIQEKGHVPHGRAGSDAEMAQAVIFFTKNSYVNGQILAVDGGVLNVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2S796</accession>
    <name>M2S796_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aromatic prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_351226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445659">
        <property type="protein sequence ID" value="EMD58245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706059.1">
        <property type="nucleotide sequence ID" value="XM_007707869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S796"/>
    <dbReference type="GeneID" id="19138075"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_351226"/>
    <dbReference type="eggNOG" id="ENOG502SHT1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037431_2_2_1"/>
    <dbReference type="OMA" id="TYISCAY"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46747" checksum="0EDB51CF7F345927" modified="2013-05-01" version="1">MVTIASQPTLIDNVPVPVTDEGPFPRTPDSNWWWEVVGSHLETLLSAAGYSDLDQLKALSFFYRWVTPRLGPKPIGPEAIWKSFMTDDHSPIEYSWKWGFGDSAPEVRYSIEPIGHRAGEALDPLNKNATSDFLAQLCRSGQTGVDLEWFVHFKHAFLGPGTPASEAGVARQSTLFVAFEVTGGSLGVKAYFIPVNAHGNSASDQISRAIVSTGCPNLAAMNQLNSFLREDIYGRTVKPFMLGIDCISPVDSRLKVYSRSLVTTFELVRRVMSIGGRRKDVTEAEKQLHTLWKLILNLPDDFPTDRELPYNPHETAGLLFYFDVGPRSQLPDVKVYIPVRHYAPSDDVAARGLVQYLKSQNQGAYAQQYLETLRALAKKDDMSTSNGLQTYISCAYRKSALVVTSYLSPQCYHPSWFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7V4</accession>
    <name>M2S7V4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_38129</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701081.1">
        <property type="nucleotide sequence ID" value="XM_007702891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7V4"/>
    <dbReference type="STRING" id="665912.M2S7V4"/>
    <dbReference type="GeneID" id="19139175"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38129"/>
    <dbReference type="eggNOG" id="KOG1353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_1"/>
    <dbReference type="OMA" id="INQRDNW"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="189"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="419"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD63263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </reference>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704051.1">
        <property type="nucleotide sequence ID" value="XM_007705861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBJ7"/>
    <dbReference type="GeneID" id="19139706"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40351"/>
    <dbReference type="eggNOG" id="ENOG502S8DA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122021_0_0_1"/>
    <dbReference type="OMA" id="MLRWFQR"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="128" mass="14166" checksum="F31D30A3E3B2DD05" modified="2013-05-01" version="1">MVDTTSLATGVLLASASALLLAAMLYPSTMLRWFQRKRYQYEVTFSLYMLTSTEKFIFNSVLFLLLSLLIIAASLYLPEHLSIIANRILYYVSGNQQSLANDAQKMSVSPNAPLGGDFPAGGRAYMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SC84</accession>
    <name>M2SC84_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydantoin racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_36276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699136.1">
        <property type="nucleotide sequence ID" value="XM_007700946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SC84"/>
    <dbReference type="GeneID" id="19138699"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36276"/>
    <dbReference type="eggNOG" id="ENOG502RZNN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053002_1_1_1"/>
    <dbReference type="OMA" id="CAGMSGM"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12500:FF:000003">
        <property type="entry name" value="Hydantoin racemase (Dcg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28000" checksum="763BCB6E7B99EF7E" modified="2013-05-01" version="1">MGEYRHGHNPRYSKMRSVLIINPNSTEQMTNGLKPLVDALQFKDTAHEYFTAPSGPKSINNEDDAAESVDHCLPALEKDLARYDGFLVACYSKHPLVPRLKEHATVRGSRKPVTGIFEASVGTSLQIIHPDEKFGIVSTGKIWESILTDATIDFLGTGSEASKRFAGVETTGLNATDLHDAPADEVRKRMKDAVKRLLKKDKVGAICLGCAGMAGMDEMVREACIEELGDVEGKRVRVVDGVMAGVAWLEGAIRASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCN5</accession>
    <name>M2SCN5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_151696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704417.1">
        <property type="nucleotide sequence ID" value="XM_007706227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCN5"/>
    <dbReference type="GeneID" id="19131563"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_151696"/>
    <dbReference type="eggNOG" id="ENOG502S3GI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066049_0_0_1"/>
    <dbReference type="OMA" id="SNHYEMF"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="266" mass="29933" checksum="6071AD6748C685BB" modified="2013-05-01" version="1">MSSSVEVRANPALIQKGDASRAPLFLLHDSGGTVSYCYRLRNIGRTIYAIHNPSFYSQEKWKGGILGLVEEYIKLIKSVVPSGEILVGGWSLGGQLGIDIGRVLARNRRSKLSVKGIVLIDTMYPYWGPPETVHADVSIDLVLKNIPSDLKESMLRCMDWSKEDCDEWVPRNWKGDIDQLGDVESEEPAPAVLIHANKLIVEETSEGVRCMVDQYKDQKNGWNFFPHQFIAAIWETPVHHFGLFEETSVQETTDMIKRACDLLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SD71</accession>
    <name>M2SD71_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF3955 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_26178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ND90Pr / ATCC 201652</strain>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_26178"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="EmrE-like"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD65383.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDT3</accession>
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698328.1">
        <property type="nucleotide sequence ID" value="XM_007700138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SDT3"/>
    <dbReference type="STRING" id="665912.M2SDT3"/>
    <dbReference type="GeneID" id="19138333"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35504"/>
    <dbReference type="eggNOG" id="ENOG502S3V4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027589_1_0_1"/>
    <dbReference type="OMA" id="WNASKDQ"/>
    <dbReference type="OrthoDB" id="21072at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2570:FF:000001">
        <property type="entry name" value="Autophagy-related protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD65458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="419" mass="45219" checksum="7BB2A698D3D8715C" modified="2013-05-01" version="1">MSSVQFTALIRLPFIRGDFEDPPQAQWDAEKDRQLWKVISKSSKTSDLNWVELADKFQVPPTFLLQQAAWLYERHLDHVRNQMKKVSITNAAPSSPTVGSTMTAVGGVAMRRGGSAGSGAGKTPSALSGRSRESPSLRNAEVATPAPSLSRTPSTTTITQSRAHAQAPARTLSTRSTQRPNLTSRKSEERAQASNLPHPSYRNDEDVSPEIPESSSSSSSSLSDADHPVHRSQLFKRPPRFQQKRPRDLATFDEGDVAQEFDESGSHETSLPFASAARTQPSSSKFAQDAQFRGSTKAEQKAVLPHRSRTDPPSRQKSIDVQSLTTETASSMTSSGGPPSAAKSPMSPPLGHRAALGRLGSPRSGGPRSRKEGSEGTPSMGSSFSDIDDAGISQSALEEALLSNMQHGRMSTLSRMSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGA0</accession>
    <name>M2SGA0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_162916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702803.1">
        <property type="nucleotide sequence ID" value="XM_007704613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SGA0"/>
    <dbReference type="STRING" id="665912.M2SGA0"/>
    <dbReference type="GeneID" id="19132207"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_162916"/>
    <dbReference type="eggNOG" id="ENOG502S5NX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063073_0_0_1"/>
    <dbReference type="OMA" id="FTYHIHV"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025607" description="superoxide dismutase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD61465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="264" mass="26467" checksum="4E315B9CFD296052" modified="2013-05-01" version="1">MLVSVISILAAASAVTAQSTNAPVVANNPIGAKYVATLPQKAGSSLSGTIEGTTAADGKGVKFSVHFAGLPATGGPFMYHLHAKPVPADGNCTATGAHLDPYHYGETMSCNASAPETCQTGDLSGKYGNFSTQEFSAEYTDLYSATLPSDPAFFGSLSFVLHLANKTRIGCANFEKVADGESNEEPPKSEDCSTSTMASTGYSIPTSAAGYNGTVPAPTAGKPTFPSAPSATSSSPAEFPGAAPKTVGGVGALLAAAAAAIFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>M2SIZ3_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703395.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SIZ3"/>
    <dbReference type="GeneID" id="19139219"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38304"/>
    <dbReference type="eggNOG" id="ENOG502S756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083991_1_0_1"/>
    <dbReference type="OMA" id="GHAIKDH"/>
    <dbReference type="OrthoDB" id="3801009at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
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            <end position="186"/>
        </location>
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            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
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            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30556" checksum="7002D712C770D1E2" modified="2013-05-01" version="1">MASQDYYGQSQGQGQQGYGQNYEGTSQRQWGSADYNQGYPPQPQSYGQPQHDQYGQANHSPYPPVQSPYPPPSYGSYGQSQNSYGASPQPVDQYQQGYDPNRSTSPYPPTAHHQQGYQDPSQEYGAPQQQGHHDPQQGYGASQYGQPGGPGDAAEGDRGLGSALIGGAGGAFVGNKLGGGTLGTLGGAILGAVAANMVPDKKEKKKHKKKHRHSSSHGSHRSHDGSDDGSHHGSHHGSSHHGSSHHSHHGSSHHSHRSSSGHRHRHKHNKSHSRGGKSSSSSSSSDSD</sequence>
</entry>
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    <accession>M2SLE1</accession>
    <name>M2SLE1_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">COCSADRAFT_80865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007697537.1"/>
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    <dbReference type="AlphaFoldDB" id="M2SLE1"/>
    <dbReference type="GeneID" id="19140806"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80865"/>
    <dbReference type="eggNOG" id="ENOG502RXE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008022_0_0_1"/>
    <dbReference type="OMA" id="WERCMGG"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="360"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="117"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
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        <location>
            <begin position="408"/>
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        </location>
    </feature>
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        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
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        <location>
            <begin position="490"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="893" mass="98387" checksum="85E0A437E7FED7EE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMC0</accession>
    <name>M2SMC0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_351145</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="472" mass="50532" checksum="2B9463AE43F58C6E" modified="2013-05-01" version="1">MTVGSNNQKISFFASGGYNETYVYGTNGFCTDSYSSGACVTFRGGAYDASKSSTDKLISSRKDSDDFKAEWMEDTLSFGINTSLSLFGFGVPKQDLNQAFTSQSQLGLGRNSSFLQALVSAGDIGTKVYSIFWGLVGGPAEKQTGGSLVLGGLDRSLISNPNDNSTASLFRGSRCRTGMVVMISDILLNWPNGTDMSVLMGSQSAAIQACISPSFAGLMTLPLSYYKNFRLLAGGTLPDNMTDARSLGINYFTMLFDLSNVYYGGLTIQLHNSISVKIPNTELVTNTSVRNVVINSLQSYNGNDLPVLGRLFMSSAYIMVNQKAERFSVWQANTGSRTPNVVAVDKQNNMISEFCTNSTGRSVDAAPSPTSSVNVLVPQNEASELSGGLIGGIIAGALGGLALLGAIGFILYRRQRLGNAAIKAVREPELQTILDVKSPTLAVVRAVPQELPANQYDIRELDSRTVGKGREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMP0</accession>
    <name>M2SMP0_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_178261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696041.1">
        <property type="nucleotide sequence ID" value="XM_007697851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMP0"/>
    <dbReference type="GeneID" id="19133127"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_178261"/>
    <dbReference type="eggNOG" id="ENOG502SHVI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007426_5_0_1"/>
    <dbReference type="OMA" id="MYDTQEP"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD68433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="736" mass="83815" checksum="D15ACA884DCB0C98" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMV3</accession>
    <name>M2SMV3_COCSN</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">COCSADRAFT_104006</name>
    </gene>
    <organism evidence="9 10">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705925.1">
        <property type="nucleotide sequence ID" value="XM_007707735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMV3"/>
    <dbReference type="GeneID" id="19129885"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104006"/>
    <dbReference type="eggNOG" id="ENOG502SMUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_12_1_1"/>
    <dbReference type="OMA" id="IRSCIYA"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD58481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="371" mass="41336" checksum="312A1FB4CFD09771" modified="2013-05-01" version="1">MSSDRTKVGVLPVPDDGNQDLDGKTDLQRRIIVVYVVMTIFSSMVLGLRLYTRTFIRRLTGLDDVLVVLSWLGCVAWLVICFEAFQYGFGQHLWNVTVEQLQVYTKMLVGIMVVYVWTPALAKLSLLALYYRLNPDFKIRSCIYALAGLVSGYSLAITIVAAGPCNPQYHSDQKCLTDLNLFMACINIITDFLILCLPVPMLRALQLPMKQKVLLGLVFALGSGVVVISTVRIIYVYSMISDPDSTYNIAKACIFSTIELNGGVICACAALLKPFIQRHMPWILSLSSGNGSGNRSRVRKFKMFKKHSNGGKFELRSTNAEKDARKQANNKLNRQIEVTRSYSVRDSRTGKNNGDSMDDLFAPTAGWNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN00</accession>
    <name>M2SN00_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_128988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705633.1">
        <property type="nucleotide sequence ID" value="XM_007707443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN00"/>
    <dbReference type="STRING" id="665912.M2SN00"/>
    <dbReference type="GeneID" id="19130731"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_128988"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="OMA" id="FTEWWYR"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="20"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="340" mass="36129" checksum="6E1173E222C2B7D6" modified="2013-05-01" version="1">MATTLRVALISNPGKPLEITDADTLHAGLGEVLIRNHAIALQPLDAKMLIAGYGPAAHLAYPAVLGTSGAGIIEVVGEHVQGLAVGDRVVFDTKAYVDASNNRRTGTWQQLVACDAKTVAKQIGDVAFEQAVLVDFPLQTAVAALHVFLGMGKPGSRAKEEKVLIWGAGGAVGSYAVQFAKQAGYTVVVTASPRDVERQMKLGASEVVNYKDTDAVAKLRSLGPYKYLFTASGDAASQSALASLLESTGGSFASVLPSAVELPSNVNLIYSAFSQAAQKEEYSKWRDWWYQEYLPKVFSGGLVEPVRFTKVQGGLSALQQASQDVFDSKVKGKLVIDPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNS7</accession>
    <name>M2SNS7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_348138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705297.1">
        <property type="nucleotide sequence ID" value="XM_007707107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNS7"/>
    <dbReference type="GeneID" id="19137879"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_348138"/>
    <dbReference type="HOGENOM" id="CLU_417371_0_0_1"/>
    <dbReference type="OMA" id="PWMRDES"/>
    <dbReference type="OrthoDB" id="3687719at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="GO" id="GO:0000981">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705754.1">
        <property type="nucleotide sequence ID" value="XM_007707564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPL9"/>
    <dbReference type="GeneID" id="19130746"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_129353"/>
    <dbReference type="eggNOG" id="ENOG502S247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040578_0_0_1"/>
    <dbReference type="OMA" id="TIDIRFF"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="164"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="375" mass="40574" checksum="94545E7EA0EDD5E3" modified="2013-05-01" version="1">MAFSFPSQYCRPPTNSSDHPSPHLQPQSPLQRGSMLGKVKRAFSTRKSSTSSNDHSARGTAVTGQTLNNTLTAAPVSPKRAGSRNSGLAPSPSSANPFTSPSPATRRPDTDRSLGSTAMNDSGSNNEAPPAYTPGPAQDASAFQSPSITTTSDSDPYAFLKSFDTVFLIDDSGSMAGRSWRETQEALATITPICTAHDEDGIDIYFLNHPDSSLYKKITTPSTIIEIFQTVRPRGATPTGQRLHKILKPYLQSYERDDKTKPINIIVITDGEPSDDVESTIIQAAKKLDKLDAPAWQVGIQFFQVGREPGAREHLKQLDDGLAELAEDDNLRDIVDTVPFSGAEGESLTAAGILKVVMGAVHRRLDRNSKDLHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPU2</accession>
    <name>M2SPU2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_36905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699819.1">
        <property type="nucleotide sequence ID" value="XM_007701629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPU2"/>
    <dbReference type="GeneID" id="19138847"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36905"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OMA" id="MYHKLGD"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000063">
        <property type="entry name" value="MFS multidrug transporter, putative (AFU_orthologue AFUA_2G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="136"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD64330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="579" mass="63872" checksum="30F4068A83569C64" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ16</accession>
    <name>M2SQ16_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_357380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700199.1">
        <property type="nucleotide sequence ID" value="XM_007702009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ16"/>
    <dbReference type="GeneID" id="19138494"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357380"/>
    <dbReference type="HOGENOM" id="CLU_1704079_0_0_1"/>
    <dbReference type="OMA" id="IHPACAH"/>
    <dbReference type="OrthoDB" id="10480659at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="154" mass="16810" checksum="F8AC5E90620FCAA3" modified="2013-05-01" version="1">MKHTLHSIYASNCLTCIIVGSAAGETGLLLLLLLLLQQAAPLISLMAQAQAVSPSRPLPSPMTHSHTRLCPPLPTTPCPSTTTAFLRNQARRVRIDDSDMLNVRDIHPACAHTHAHNVMPAMTPTRPSPISPPLVLPCPRHFCFVAPHYCRVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ47</accession>
    <name>M2SQ47_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_166351</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694706.1">
        <property type="nucleotide sequence ID" value="XM_007696516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ47"/>
    <dbReference type="STRING" id="665912.M2SQ47"/>
    <dbReference type="GeneID" id="19132443"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_166351"/>
    <dbReference type="eggNOG" id="KOG2923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155991_4_1_1"/>
    <dbReference type="OMA" id="IYDPDMF"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="83" mass="9516" checksum="DB863A0064538DFD" modified="2013-05-01" version="1">MADEELNLYDEIEIEDCFYDETLQIYHHPCPCGDRFEISIFDMRDGEDIARCPSCSLMIRIIFDPSDLPPENDDTPQSVAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQX7</accession>
    <name>M2SQX7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_40708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704465.1">
        <property type="nucleotide sequence ID" value="XM_007706275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQX7"/>
    <dbReference type="STRING" id="665912.M2SQX7"/>
    <dbReference type="GeneID" id="19139812"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40708"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_0_0_1"/>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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            <end position="204"/>
        </location>
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        </location>
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        <source>
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        <source>
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    <sequence length="767" mass="86475" checksum="E233E1407BABE56E" modified="2013-05-01" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <end position="153"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="235" mass="26512" checksum="8FF3EC930092DF79" modified="2013-05-01" version="1">MIWILLDRLVVSLRDGIRANRTNVDANKTSCFPSNKDRRTCMACRNRTAPWSGIWLRRATRAARPTGSANHHPLACPMASNLIWSLSRVEKWWAACYLKTDYATRVMETAMQCRPKGSPRRQVRRGAVYVCMYVCVCTYVACMYVCMCMYAAYPACRHGDGEEGKGGPLSQRTHSLCNRACTLHCVCTLGTQTLHTRRHFVSPRAAVALTYGDASTGVLLRFDYSTTRLLDMHSK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:NADPH regeneration"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37195" checksum="B79F892C5775B946" modified="2013-05-01" version="1">MTIGIAIIGSGIFAKEEHLPAIQDAPILSLKAVYSRSLKSAQSLSEKLSGVDLYSDDQDGKRFDDLLKRDDIKGVVIALPILAQPDYIKKALAAGKYVFAEKPIAKDLTAASSLLSWTSNPANTSVTYTVAENFRFIDSYIWASQQLASLGRVLSFRVRVMFFVPVGSKYYETAWRKKPEHQGGFVLDGGVHFVAATRLLLQGAGQKVKRVSAFTAQLQEHLPPVDTLNAVLQLENGSSGTLSISVGTTDQGSEYVVACEKGVVTVSRGKVVVKRQGEEGETKEFPDEGNGVKQEIKAWAKSLEEGKRNEMQSPEEALKDLEILESCLKSGEQGGTPIDVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVL4</accession>
    <name>M2SVL4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_353513</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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            <dbReference type="Pfam" id="PF17111"/>
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        <source>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
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    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Vid27"/>
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        <property type="entry name" value="VID27_C"/>
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        <property type="entry name" value="Vid27_PH"/>
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        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
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    <dbReference type="PANTHER" id="PTHR31913:SF0">
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            <end position="435"/>
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            <end position="403"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08553"/>
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        <source>
            <dbReference type="Pfam" id="PF17747"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
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    </evidence>
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            <dbReference type="EMBL" id="EMD66670.1"/>
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    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="91375" checksum="E15C939DDBEB4130" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWS1</accession>
    <name>M2SWS1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_173760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702774.1">
        <property type="nucleotide sequence ID" value="XM_007704584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWS1"/>
    <dbReference type="STRING" id="665912.M2SWS1"/>
    <dbReference type="GeneID" id="19132877"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_173760"/>
    <dbReference type="eggNOG" id="KOG2487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040211_0_0_1"/>
    <dbReference type="OMA" id="QGCDITS"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000084">
        <property type="entry name" value="Transcription factor TFIIH subunit Tfb4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD61421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="377" mass="39900" checksum="26BB0D48DD2A873E" modified="2013-05-01" version="1">MNTIDGSDRHIKTEEAPPPSLLAIVLDTNPHAWAHLSSTLSLSTALANILVFINAHLASGNTNEVAVIASHSHKTTFLYPSPVAPQAQSRNGIANGDVEMNGIGDDKGQHTAESANKYRPFAVVESTILQNFVKLLNETKESHLEATPTTLIGGALSLALTHINKQTILHAPTAASAESASLAALADSENTHVDRVSLTSRILIVSVSGDLANQYIPVMNSIFAAQRKRIPIDILKLAGDTVLLQQASDATGGVYMKPERPEGLLQYLMMAFLPDVTARASLVVPSAGGVDFRAACFCHRKVVDIGFVCSVCLSIFCSPDLPDNLCLTCGSYLSLRSAMTNPPALIPRKKKKKKKAGMDSATPGANTPVGSGTPAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXM1</accession>
    <name>M2SXM1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_351760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696811.1">
        <property type="nucleotide sequence ID" value="XM_007698621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXM1"/>
    <dbReference type="GeneID" id="19138113"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_351760"/>
    <dbReference type="eggNOG" id="ENOG502QS1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030203_0_0_1"/>
    <dbReference type="OMA" id="FNGYQYA"/>
    <dbReference type="OrthoDB" id="9978204at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15892">
        <property type="entry name" value="BNR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025448" evidence="1">
        <location>
            <begin position="20"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="435" mass="47915" checksum="A8B79EF3119C449D" modified="2013-05-01" version="1">MKLFSSLLALVGLSSFTSALSVTSVKNWNITDDVQGSVRLNGLAFQQHALTTFGDYQYVAFYKTASGYGKHYVNLGRRKISPSLGDWQYFAFSDYEQTTLDEHNTISVGISGDGKIHLSFDHHDVPLNYRVSKAGIAKTVPSEWTASAFGAVQHNLPGSTGPWTPLTYPRFESIDGGDLLMEFRIGQSGAGDSYIHRYSATTGKWTAVGKYLQGEDNNAYINGISSEGGKLFVSWTVRETPDASTNHDFYFAFSEDAGKSWKQTNGQTVAVPIKPSTPGVKVYSIPQNSQIINQEAQFVDRQGRFHALMRDNSTGTPRFYHYLRTPAGKFTKTVINAPGLSTPPYLAYRGKIVATSDSVIAILPDQPKMTIQLWAATAGANYNDWKKIADIPNSAGEPLVDEARLKNFNVLSLFVRQGGPFPTRKVQVWDFGLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY28</accession>
    <name>M2SY28_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_163131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702986.1">
        <property type="nucleotide sequence ID" value="XM_007704796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY28"/>
    <dbReference type="STRING" id="665912.M2SY28"/>
    <dbReference type="GeneID" id="19132222"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163131"/>
    <dbReference type="eggNOG" id="ENOG502S6BC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021798_0_1_1"/>
    <dbReference type="OMA" id="MLNRDCR"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="424" mass="45519" checksum="6B7996A5F08F80A1" modified="2013-05-01" version="1">MPRPNLPPTPQPSTDITGKNAANAPQLESSFDLPPAALGGRGSVASSSGPSENASDSSYRPLSPSSPVATSKSSHSRKRSSNAAQHSVVTRDDYSLPPPPTRSRKIIQMKPKDTQESPKASVQSQNAKTTSATANGGKKKQASNTTAAGRKIARKTAHSLIERRRRSKMNEEFGVLKDMIPACRGQEMHKLAILQASIEYMRYLEQCVSDLKTANSRRDSPSSTTSSLPPPPVRRIHDEDEDDREQDEEMEDAVSPTYVEQPASQSRYSFANASPAICPSDRSVYTHSTTTSPAIMPHDHNGHYSANPSPALRPSDPHHYSLAPSSSHSTVTSPTIHPSPAFSAHTPTATYFSNPFHTGPPSTGPVAAPGSSHGSAHFSLTSPALKPQADREDQEATEALMMLNTDRRSWSGARGMSVKDLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY81</accession>
    <name>M2SY81_COCSN</name>
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        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_29073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD61762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY81"/>
    <dbReference type="STRING" id="665912.M2SY81"/>
    <dbReference type="GeneID" id="19135990"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_29073"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110381_1_1_1"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14347" checksum="75C43EAA9C62564D" modified="2013-05-01" version="1">MSAPKVKTAQLWNKSKDELASQLADLKSELIQLRTAKVTGGSNTKLTRIHDVRKGIAKVLTVINANQRAQLRLFYKGKKYTPLDLRPKQTRAIRRRLTKHEASLVTEKQKKKQTHFPQRKYAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZI7</accession>
    <name>M2SZI7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate-binding module family 35 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_147716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702483.1">
        <property type="nucleotide sequence ID" value="XM_007704293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZI7"/>
    <dbReference type="STRING" id="665912.M2SZI7"/>
    <dbReference type="GeneID" id="19131426"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_147716"/>
    <dbReference type="eggNOG" id="ENOG502QW2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016116_1_1_1"/>
    <dbReference type="OMA" id="YASQTTF"/>
    <dbReference type="OrthoDB" id="9970295at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025950" evidence="5">
        <location>
            <begin position="19"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="446" mass="48289" checksum="AD668A9088D7821F" modified="2013-05-01" version="1">MRLFSIAGLSLLASVATASLQIVPGATWTATNIGQHIQAHGGGIIKDGGKWYWVGEDKTNGSSFQNINCYSSSNLVEWTYEGAILSRTASGDTGPNRVIERPKVIHNKKTGKYLLWMHIDSSDYKDAKIGVAIGDTVCGKYTYLRSERPLGFESRDSGVFVDDDGKGYLLTEDRANGLRINALSDDYLNITRNVYKWAEKYESPAVIKSNGVYFMFASQLTGWNPNDNYYSTSTSLSGPWSAWKKFADSGSNTYASQTTFVLPVGNSFMYMGDRWHSENLMRSTYIWLPLQISGTTATMKNAVNWIINPSTGAMTAGPTENSYEGESATLASGARTISCSSCSGSQSAGYIGGTSSGVITFANAQYSATTRTTLRIKYLNGDSSQRYADVTVNGKMQKVAFVPHGGGDPGSSVVHVDLKQGSNEIKIAGNNGGWGPDIDRVFVPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZV1</accession>
    <name>M2SZV1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">feruloyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_82629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697394.1">
        <property type="nucleotide sequence ID" value="XM_007699204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZV1"/>
    <dbReference type="GeneID" id="19140906"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82629"/>
    <dbReference type="eggNOG" id="ENOG502SD05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_3_1_1"/>
    <dbReference type="OMA" id="VPLMEFH"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF2">
        <property type="entry name" value="FERULOYL ESTERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032329230" description="feruloyl esterase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD67845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="314" mass="34366" checksum="BAA2F171BE1DA55E" modified="2013-05-01" version="1">MKALVIVSTLATVLVADNSNGCDKPLPDGVLPGESTGLTINSESGVTPRGYRLHIPTSYEKNTPSPLILSFHGRGKTAEYQEALSQFSNTSYGFEGIAVYPEGVPNKKGTQQFQGDPDAPKSIDDVAFTLELLDHLETTYCIDTSRIYATGKSNGGGFTGILACDTEATKRIAAFAPVSGAFYLDANQQPPPCNPSRKPVPLMEFHGYRDTTIPYEGGINTRGNANSSDVVTYVNDWAQRNGYDTRVNTTTYLCDGERKVTRHSWDDVVVHYNYTNIGHDWPSSFPNGDTNDLLTCEEAGATSIVLEWFKKWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2T015</accession>
    <name>M2T015_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <source>
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        </source>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="TELO2-interacting_protein_1"/>
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        <property type="entry name" value="TTI1_rpt"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3N2</accession>
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        <recommendedName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700849.1">
        <property type="nucleotide sequence ID" value="XM_007702659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3N2"/>
    <dbReference type="STRING" id="665912.M2T3N2"/>
    <dbReference type="GeneID" id="19141402"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_91438"/>
    <dbReference type="eggNOG" id="KOG3739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005130_0_0_1"/>
    <dbReference type="OMA" id="PFQKFAH"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="348"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="731"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD63856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="846" mass="92595" checksum="0C76C363720BCDCE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2T542</accession>
    <name>M2T542_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_177271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694835.1">
        <property type="nucleotide sequence ID" value="XM_007696645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T542"/>
    <dbReference type="STRING" id="665912.M2T542"/>
    <dbReference type="GeneID" id="19133074"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_177271"/>
    <dbReference type="eggNOG" id="KOG2215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012488_2_0_1"/>
    <dbReference type="OMA" id="AAWLPNR"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="9">
        <location>
            <begin position="455"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="679" mass="77357" checksum="821932FFCA64782C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T548</accession>
    <name>M2T548_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_32245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ND90Pr / ATCC 201652</strain>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700253.1">
        <property type="nucleotide sequence ID" value="XM_007702063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5G1"/>
    <dbReference type="STRING" id="665912.M2T5G1"/>
    <dbReference type="GeneID" id="19134113"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_199863"/>
    <dbReference type="eggNOG" id="ENOG502RXNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047849_0_1_1"/>
    <dbReference type="OMA" id="PGFKYAM"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="459" mass="51059" checksum="18CA8D6391A92892" modified="2013-05-01" version="1">MSDKVVDPAARDKYLLQVTAGPSYNPSEHEQVAVNGADPTYIESDLLSAWIRVRIKDYHGLPRGSPASSSYFDHPQHTSDRYSIAYSFVPKQNMSGSDLVMGFDYGHSIRHQLPPGFKYAMKIATSLLDPGLYSDPYSDQPYLYGPALSSFFAFQIGEKTSVMSPSDQLSRLEQDSANVIEEGAYGSGVEIRKILNMPPKWKKRRKFFLDAKALADFTFEKDRMYHADFFNPHLDFANFALRLPGFSISVARYVDEKTHHLRYVLKNRKTEEALLVVIFRLLYGKELEATLEQEKNNGNVAAAPETTTTQSGENSTDHDGQIKVSPVEEAERTTSQSPPATTEHNVAKLERPEPMATESSATDSEHDDRNGQGYIGQASTAISSLTSSVVAVYAALGFKYSSSSASDSEASNRSRSPQPSDQSMEARIDDMDNETVEKFLRDQTSNVRDAPRASHSQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5I7</accession>
    <name>M2T5I7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_142589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700109.1">
        <property type="nucleotide sequence ID" value="XM_007701919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5I7"/>
    <dbReference type="STRING" id="665912.M2T5I7"/>
    <dbReference type="GeneID" id="19131246"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_142589"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100842_0_0_1"/>
    <dbReference type="OMA" id="CLEVRIN"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026437" description="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II" evidence="2">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="24901" checksum="EBD6AD3FAD2895A7" modified="2013-05-01" version="1">MAQLRVWLAAGALAAASAVQVKRAPYDSRSGLQVVSNATTTTVLGSSGGPVWTSSSGGRYQACVGRPFCLDGASEFRAIPYLEHTCVERVASGGYMSAALSAEGELFVWGQACPGSTGDMDVLNGNADGHTPSTGIGTEEDADEFVKCLEVRINGKEARVYQVAIGHGHILVAAESGNGSSAKERVVFGAGDNSMGQLGLEERRFYSAFHEVQSLRGKRVAQLYAAGWSSFVVTLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5M0</accession>
    <name>M2T5M0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_90395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700141.1">
        <property type="nucleotide sequence ID" value="XM_007701951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5M0"/>
    <dbReference type="STRING" id="665912.M2T5M0"/>
    <dbReference type="GeneID" id="19141345"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90395"/>
    <dbReference type="eggNOG" id="KOG3308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058668_1_0_1"/>
    <dbReference type="OMA" id="FMSIPYE"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27995" checksum="6715B155DC35C699" modified="2013-05-01" version="1">MSSPLLVGISGPSSSGKTTLSRLLRDVFPPSKLFILHLDDFYLTDAQIPVKNGIQDWDCIESLNLPALKQVLDHIKDQGKSPDWLVSQEDQNSVGEHGVPESEIQALRERVAGLLEGKPEWSEKRICIVDGFLLFSQDMKDIRSTFDVRLFLRTSYETAKRRREARSGYVTLEGFWQDPPGYVDKIVWPNYVHDHSFLFENGDVNGQLDSEVCAETDIHGMPKEAEENMAECLSWAVRVLEDVIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5X8</accession>
    <name>M2T5X8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Golgi apyrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_214433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    <dbReference type="OrthoDB" id="3692536at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="175" mass="19171" checksum="6A5BD3273A3628C7" modified="2013-05-01" version="1">MPPKAQPPPRGVWANANTNSLQFYTNGGPNNTINNKDIRRIFNYFCRPRGNSPYNAIFSPSPRDYSPMIARTTITAQQILTSRPSYLKAFIIHSRGALNAAFYTNNCAAILRGEKKFTAFASCVSIADHRARYSVTQQAVSRIGGGRKRLPNGPSSGNQRGRPAAGSAENPLLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9N3</accession>
    <name>M2T9N3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoacetate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_198802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698964.1">
        <property type="nucleotide sequence ID" value="XM_007700774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9N3"/>
    <dbReference type="STRING" id="665912.M2T9N3"/>
    <dbReference type="GeneID" id="19134073"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_198802"/>
    <dbReference type="eggNOG" id="ENOG502RXEA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098009_0_0_1"/>
    <dbReference type="OMA" id="YNEYTHG"/>
    <dbReference type="OrthoDB" id="10248817at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27614" checksum="C4F5258B8B5CA060" modified="2013-05-01" version="1">MLKGTLSLSNDAIPNYSPPYPTGPYDNEFEDINTTVIQYRVAGSEIRHLIPDIMEIEEETLMTSTFVHYGKSSVGSYNEFVLQAEVRFNGQKYHYSIILILDNESAIFAGRELFGIPKVFGKVDIKTSTGSRLYQGTVERPVGTPIVHFNFIPERRVESVPKDDTLHLGLRSIPSLANPQTAAIKELVPSSMEWHVKSAWIGKGSLVFTPGTLLHPWADLKILRYEGAIFSEIPRAFLLVRFSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2TA51</accession>
    <name>M2TA51_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_309905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698846.1">
        <property type="nucleotide sequence ID" value="XM_007700656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TA51"/>
    <dbReference type="GeneID" id="19136362"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_309905"/>
    <dbReference type="HOGENOM" id="CLU_2096690_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="116" mass="13152" checksum="1681F5A58632CF45" modified="2013-05-01" version="1">MPRLRPVATLSLHGRTILQAAIFSYPAATLEESCRLALVPLFLSIDRLSQDSSVLIESGYPRLRTRRAPTINAFLNFSPQRNTATAMNILAGCLSSTMSRFRRYLLYWLHPEHIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCH3</accession>
    <name>M2TCH3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_82948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696701.1">
        <property type="nucleotide sequence ID" value="XM_007698511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCH3"/>
    <dbReference type="GeneID" id="19140923"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82948"/>
    <dbReference type="HOGENOM" id="CLU_2711531_0_0_1"/>
    <dbReference type="OMA" id="INTVNFW"/>
    <dbReference type="OrthoDB" id="3662865at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="73" mass="8322" checksum="F4940252D36BDB9B" modified="2013-05-01" version="1" fragment="single">QAPTASGRDQSIADRTTRCCRDNRGTMINTVNFWNRGNFYCRVPNSVTPADWDQNCCRKWYGSGTYGFCNQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDC9</accession>
    <name>M2TDC9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_110818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696952.1">
        <property type="nucleotide sequence ID" value="XM_007698762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDC9"/>
    <dbReference type="GeneID" id="19130134"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_110818"/>
    <dbReference type="eggNOG" id="ENOG502SPJH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_31_4_1"/>
    <dbReference type="OMA" id="AYQWSLQ"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="2">
        <location>
            <begin position="146"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="323" mass="36602" checksum="161C47AAD32683DB" modified="2013-05-01" version="1">MARTVNRIWLNPSTTGERPPPIPGTVPGYSADLGMIAALQLDDDSVILLPQEYIHDPDDSPDASWRGEHGARRCWQTTVIYEEQISESHPHLVPYLRRDPWTAFPVLAKPSGPPVTDFIQQNKAAMYSAPLDAASSRILASYRPLMFQWALHIISALSFIHAHNIIFGDLSLEDCWLSSDSRLSLSLVGFVSAGFRRRTNGVWYHCTRSSGEWFHPLEHQSQQSIQTDLFLYGCVVYELMTGFWPGDRTGKSWQEVSMMIPRREWPPLEIEHMGEIVRKCWEGGFADAEQLKMEVVVFLEGLGWSIEGNDDLKGFDVAHLSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDV4</accession>
    <name>M2TDV4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_34234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696571.1">
        <property type="nucleotide sequence ID" value="XM_007698381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDV4"/>
    <dbReference type="GeneID" id="19137537"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34234"/>
    <dbReference type="HOGENOM" id="CLU_2512474_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="85" mass="9299" checksum="A1787FA424A3634C" modified="2013-05-01" version="1">MTFHIPPLLLSTLSHSFSLSKPFHNLSSPQPILQRTHPTEHTCTRETATHLPPFLASSLVLTPRVSLGSRQASPATSTNNEITTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEL8</accession>
    <name>M2TEL8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_34464</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696619.1">
        <property type="nucleotide sequence ID" value="XM_007698429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEL8"/>
    <dbReference type="GeneID" id="19137670"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34464"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OMA" id="CVCQYIV"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="21"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD67671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="533" mass="58444" checksum="A6854345B7AB556B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TER6</accession>
    <name>M2TER6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_34516</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696633.1">
        <property type="nucleotide sequence ID" value="XM_007698443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TER6"/>
    <dbReference type="STRING" id="665912.M2TER6"/>
    <dbReference type="GeneID" id="19137694"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34516"/>
    <dbReference type="eggNOG" id="KOG1617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_0_0_1"/>
    <dbReference type="OMA" id="RGRMIMA"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD67726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="401" mass="43659" checksum="BE827C2ED4E8FE34" modified="2013-05-01" version="1">MTPLSAARAISPCHIPAALPRTSIGLGSIFRPAHGWPSLYLAASRASGTWARNDVKKYQHRRVVRSSAYGQCGQGHVGLFSTSTTRRLGIEDKAKESSASRNNAEQHVPSTSASAKLATTIKSTLKLDKPRHEQIYNLPNMLTFSRLIATPAVGYLIIHDQHLYAFSLFVYAAFSDLLDGWIARRWNLQTVVGSVVDPMADKFLMTTLVTCLAVNGSLPMPLACLILGRDVSLAISALYYRYASLPAPKTMARYWDFSLPSAEVHPTTVSKLNTFLQLSLLGTLLCTNLLHDPSATTSAAGGLLMSIQDVLGGEQGVKTLVQGMSAIVASTTIYSGLEYTWSKKAVVILGGDEALKRKQGFRGRMIMAAGFGSFISLAAYFWVNRRAEEEIKEKARKKLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2THP4</accession>
    <name>M2THP4_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_33611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695585.1">
        <property type="nucleotide sequence ID" value="XM_007697395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THP4"/>
    <dbReference type="STRING" id="665912.M2THP4"/>
    <dbReference type="GeneID" id="19137233"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33611"/>
    <dbReference type="eggNOG" id="ENOG502S70K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072876_0_0_1"/>
    <dbReference type="OMA" id="GVAHSGM"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="247" mass="27061" checksum="C74495681FFB7598" modified="2013-05-01" version="1">MAFRPLLRQRAVVPAMAALSATAIFAPRSVYAEERQEDYSNRKPIYDDMPIDATTPTAPSLPAPSRSAPSEEPVYRPTPTDRLAVQIGRARMALYEQAVRGEKAVDNALTETLRLEHSFTSTIRSLAPPKESGEKVLPGALYVLVASMAGSIVTRNRNILLRASVPLAVGITAANVVLPITSKNVGDLIWTYEERYPVVADTHLRMKKRILQFVETGKAHAQGTVGAVEGKLADTRESLEDWVKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI84</accession>
    <name>M2TI84_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_23314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695387.1">
        <property type="nucleotide sequence ID" value="XM_007697197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TI84"/>
    <dbReference type="STRING" id="665912.M2TI84"/>
    <dbReference type="GeneID" id="19134819"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_23314"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="217"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="704" mass="76797" checksum="30EA73112E58EED5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJD3</accession>
    <name>M2TJD3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_195142</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694671.1">
        <property type="nucleotide sequence ID" value="XM_007696481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJD3"/>
    <dbReference type="GeneID" id="19133921"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_195142"/>
    <dbReference type="eggNOG" id="ENOG502S1H2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063084_0_0_1"/>
    <dbReference type="OMA" id="VSDCAQM"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026807" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD69306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="251" mass="23675" checksum="1ACDC040B4613F5A" modified="2013-05-01" version="1">MKSFAILAATFAGAAFAQQMPTGDCAMLCVNNMARIAQSEFSCGSDDIACFCSRSNWAFGIRDCSRQACDAEQSASAVQWAYARCSGIAATASEQPAALPILTSAVASATASGGNAASSAASGASSAASSVASGASSAASSAASEITSAASSVASEASGLTSSILSEANSAISSLQSEASEVLSSATEALSSATGAAGSAASSATDAAGSAASSATDAAGSAASTEAQGAAPKATGISIAAGAGIAAWLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJF8</accession>
    <name>M2TJF8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_109847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696347.1">
        <property type="nucleotide sequence ID" value="XM_007698157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJF8"/>
    <dbReference type="STRING" id="665912.M2TJF8"/>
    <dbReference type="GeneID" id="19130105"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_109847"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_4_2_1"/>
    <dbReference type="OMA" id="TVGQAPK"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="562" mass="62151" checksum="88AF387CB4FA887E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJS3</accession>
    <name>M2TJS3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_78086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694423.1">
        <property type="nucleotide sequence ID" value="XM_007696233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJS3"/>
    <dbReference type="STRING" id="665912.M2TJS3"/>
    <dbReference type="GeneID" id="19140641"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_78086"/>
    <dbReference type="HOGENOM" id="CLU_013929_19_0_1"/>
    <dbReference type="OrthoDB" id="5425161at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="91" mass="10556" checksum="0636C55CE3D13585" modified="2013-05-01" version="1" fragment="single">DWLYTTSENRWTLNSIGSEWLQQIFILNTAPTSGRYQLLLLNSRGSHTPIKFMGLYKVNKIHLLYLLAHASYVLQLLDLAPFCVPKSRYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK51</accession>
    <name>M2TK51_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_130419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694511.1">
        <property type="nucleotide sequence ID" value="XM_007696321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TK51"/>
    <dbReference type="STRING" id="665912.M2TK51"/>
    <dbReference type="GeneID" id="19130787"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_130419"/>
    <dbReference type="eggNOG" id="ENOG502QPIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032141_0_0_1"/>
    <dbReference type="OMA" id="PHGTWFN"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09615">
        <property type="entry name" value="Jacalin_EEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026031" description="Jacalin-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="299"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="440" mass="46577" checksum="B4324D5C74DCAFAB" modified="2013-05-01" version="1">MHSILASAVALSSLLPLSLAQTSGTLNTLTFNVAGLPAALNGNDVPGDKTANTARIGELFTKYNISLIHVQEDFNYHATLYASDKHPFRTATSGGVPFGSGLNSLSNFPFTSFNRVKWNTCSTFDSADCLTPKGFTAMRVKFAEGVVIDAYNLHADAGTTDADNKARADNLRQVSDYIKTYSIGNPVIVFGDSNSRYTRTNDIPAIFKEQNGMTDVWVDLIKKGVPPAKGADALLCSNPSTTNECEIVDKTWYRGSAAVKLTAKKFDYAGHMFLQDNGDILSDHNGVLVDFDWSAVDRFTLSDTFGGEGGNWFNDLDTVAGVSGAKVASVTLRGADRVDSIAFKLASGQTLAHGGTGGTEASLTLASGETLSSATMCQGQRNGANRLFYVEFKTSAGKSVSTGVKTSDCVTRTAPAGKSIVGLLGRAADGVDQAGLIYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK87</accession>
    <name>M2TK87_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_106262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694867.1">
        <property type="nucleotide sequence ID" value="XM_007696677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TK87"/>
    <dbReference type="STRING" id="665912.M2TK87"/>
    <dbReference type="GeneID" id="19129992"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_106262"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OMA" id="NHTPFTG"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="519" mass="55801" checksum="CF5921089D4E5E45" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKL5</accession>
    <name>M2TKL5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate-binding module family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_195078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="6">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Zhong S."/>
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        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695052.1">
        <property type="nucleotide sequence ID" value="XM_007696862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TL19"/>
    <dbReference type="STRING" id="665912.M2TL19"/>
    <dbReference type="GeneID" id="19140680"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_78796"/>
    <dbReference type="eggNOG" id="ENOG502TGPM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356034_0_0_1"/>
    <dbReference type="OMA" id="VANWADY"/>
    <dbReference type="OrthoDB" id="3889716at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="773" mass="90236" checksum="6CAC1691A27FF4EE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLS0</accession>
    <name>M2TLS0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_132639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695235.1">
        <property type="nucleotide sequence ID" value="XM_007697045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLS0"/>
    <dbReference type="STRING" id="665912.M2TLS0"/>
    <dbReference type="GeneID" id="19130858"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_132639"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012923_5_0_1"/>
    <dbReference type="OMA" id="CIKLIVM"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD70101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="360" mass="40063" checksum="4D9E0E32E323CF0D" modified="2013-05-01" version="1">MDILVLAARSHLERRAKEHTCPEANTEGPEIRYFVGELTFHRFATMLSGGCAILSTVIVAVLIGFHAFNYSNPVQQRQVIRIVSLIPWVAIFSFFIVWQDGIGEYLAHSLDFGCAMALSSFLLFMCDLVLAHPGGYESLFGENARAKGELKAQSPAWLRKTWYGVLQFIPTSIILWVATAISLAAGTYCKQSNSVHFAHIWITVLNAYTTVVAIICSLRFYKKNKTLLQKHSILLKLATFKGVLGLNFFQSFIISILAGHGVLKPTEYMTFHDVNTGLASLILACEMPIFAILLVFAFSPRSYKAQGGPATGPLNAIVDAINITDLLSAFYRGPMRLVRDQQRQILRQDSMRIQAMPHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2QXL2</accession>
    <name>M2QXL2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_40968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704530.1">
        <property type="nucleotide sequence ID" value="XM_007706340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QXL2"/>
    <dbReference type="STRING" id="665912.M2QXL2"/>
    <dbReference type="GeneID" id="19139877"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40968"/>
    <dbReference type="eggNOG" id="KOG3330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD59809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="192" mass="21874" checksum="29AE71DD1286AE28" modified="2013-05-01" version="1">MSSSTKAARMGEEVWKTRVDKVSAELVTLTYGTIVAQLCKDYEYNYPDVNKQLERMGYNIGIRLIEDFLAKSSAPACTNFREVAEMISKVGFKIFLNITPTITNWSSDNKQFSLIFEENPLADFVELPDDGRAQDELWFSNILVGVLRGALEMVHMQVEAHFVSDVLRGNDTTEMRISLVRYIDDEMPPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZW7</accession>
    <name>M2QZW7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_98746</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703903.1">
        <property type="nucleotide sequence ID" value="XM_007705713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZW7"/>
    <dbReference type="STRING" id="665912.M2QZW7"/>
    <dbReference type="GeneID" id="19141815"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_98746"/>
    <dbReference type="eggNOG" id="KOG2900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_3_2_1"/>
    <dbReference type="OMA" id="NICTTHT"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="92"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD60594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="404" mass="44361" checksum="66F9DBA3F8D76B34" modified="2013-05-01" version="1">MAQRMLLRASGPRRVYYGFTRSFSTVLDTPVDPGTQQIRRATPRTTVFENALNAKIPRTNWTKDEISEIYNTSLIDLTYASASVHRRFHDPAAIQMCTLFNIKTGGCSEDCSYCAQSSRYDTGLKATKLSSVESVLEAARIAKENGSSRFCMGAAWRDMRGRKTNLKNIKEMIKGVRGMGMEACVTLGMVDAAQAKELKDAGLTAYNHNVDTSREHYPSVITTRTYDERLNTIKNVQEAGIHVCTGGILGLGEKARDHVGLIHTVATLPAHPESFPVNALVPIKGTPLGETQAISFDAILRTIATARLVLPTTIIRLAAGRHTMREEKQILCFQAGANAVFTGEKMLTTACNGWEEDKAMFERWGLRPMKMEETIGEKRKVPGQDEAEAVVAAAEAEATVQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3H0</accession>
    <name>M2R3H0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore assembly and biogenesis-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_39460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702653.1">
        <property type="nucleotide sequence ID" value="XM_007704463.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19139501"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39460"/>
    <dbReference type="eggNOG" id="ENOG502T2BZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1669046_0_0_1"/>
    <dbReference type="OMA" id="FIQDYAA"/>
    <dbReference type="OrthoDB" id="3559694at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18155" checksum="29EFDF08E0544000" modified="2013-05-01" version="1">MDFIQDYAAFLPRLLPPSFADPALHIITTFLGFSRTLSTHLSPLLNKLITQPDVASIVALLFIFFISLKILDMMYRAVVFWINLAFRLAFWGGILVVGLWVWNRGPEGFVDDVSGLIEYWMGEYERYSGEVKMFQQQKEDQIRFKAGQQQKRKGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3K5</accession>
    <name>M2R3K5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_343283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702191.1">
        <property type="nucleotide sequence ID" value="XM_007704001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3K5"/>
    <dbReference type="STRING" id="665912.M2R3K5"/>
    <dbReference type="GeneID" id="19137594"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_343283"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003324_0_0_1"/>
    <dbReference type="OMA" id="GKDYCAE"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="309"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1156" mass="126458" checksum="9F0FD5DA41680D2C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2R845</accession>
    <name>M2R845_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_161646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701366.1">
        <property type="nucleotide sequence ID" value="XM_007703176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R845"/>
    <dbReference type="GeneID" id="19132112"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_161646"/>
    <dbReference type="eggNOG" id="ENOG502QUUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_1_1_1"/>
    <dbReference type="OMA" id="ECAPAGY"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </evidence>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2REK9"/>
    <dbReference type="GeneID" id="19141278"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89083"/>
    <dbReference type="eggNOG" id="ENOG502QQMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034390_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="3">
        <location>
            <begin position="238"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="333" mass="36411" checksum="E9F6FDFCCF9F5916" modified="2013-05-01" version="1">MEADADGIAEKVQSLSDLELAVLICLIAEQHCVIECEVEGLRGVQVELELVAAKVFGLACAVLECDEGMSLDEFGRGILVDGEGEEDGGRIANVVVARELNRASEQVQVQALELIRGKRNFTRTAVHAAPKPFLFIALNAADSPRLTIHLNDQFFISHRHQVEDGLPNLEELQEKERVFDDASSMSSVVRTVPFMAGKHKPQSALFTSEDLANLSKLTAGVKISSEVRAYLYNIVVFMRLHRAVAGGVSALATRHFSMLAHTLAPLHGLDYMSPSMVALAARKIYPHRIVITAPEHERSMQWGSSLEAVKAVLEGVTPEDVIEEVLESVEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RFE7</accession>
    <name>M2RFE7_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_306199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65484.1"/>
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        <property type="nucleotide sequence ID" value="XM_007700432.1"/>
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    <dbReference type="STRING" id="665912.M2RFE7"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
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        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="381" mass="42994" checksum="4F9926FDE2A8F5E9" modified="2013-05-01" version="1">MPDLNAQQAENHYFDNEPPPKDLKANITLAREFITRHADEHRRVVLVTSGGTTVPLEQQTVRYIDNFSAGTRGATSAEYFLQNGYAVIFLHRQFSLLPYSRHYSHNTRSFLDYMKEENGQVVVDEQHQDQMLRVLRQYTEVKRGNKLLILSYVTITEYLWNLREVAQLMRPLGPKAMFYLAAAVSDFFVPQDRMVEHKIQSNEEFHQGADGITASHAKPPAARTQGKSLIIDLEPVPKFLKQLVDGWAPEAMIVSFKLETDPSLLVTKAKYALNKYSHHLVIGNLLLTRKWEVVFVSVLEGEKWIRVPTSRRTKSLSGRPSLVGSADQLTKKDDEAGGSIATERGIPQGEPSVEIESLIIPEIESMHSKLIEQAQKGAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJ23</accession>
    <name>M2RJ23_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar segregation subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_24795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RJ23"/>
    <dbReference type="STRING" id="665912.M2RJ23"/>
    <dbReference type="GeneID" id="19135151"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_24795"/>
    <dbReference type="eggNOG" id="ENOG502QU5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010147_0_0_1"/>
    <dbReference type="OMA" id="QHRYHSR"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1070" mass="115426" checksum="D170321611FFB2BF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJY0</accession>
    <name>M2RJY0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_110367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RJY0"/>
    <dbReference type="GeneID" id="19130122"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_110367"/>
    <dbReference type="eggNOG" id="ENOG502SV1N">
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    <dbReference type="OMA" id="FESEHAW"/>
    <dbReference type="OrthoDB" id="5120991at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="372" mass="42861" checksum="EE1D12BE08E20800" modified="2013-05-01" version="1">MGRPVFTSRDNLHLLRSSAFESEHAWLYDTSYMQHGAAALELEHEIEQAYSSISPDDLSDEQVRIIKTQITIHRERQRALRPHLESGSDQIDEEGNECVFVPAPNQWGANGDLDEESETLSAIHNLLTWQTSYSPISHTLHDELPSTNIPYHALLDPSVPTTTFHLHRTREWTGSSGFRKYIYSARDHSDKYMLYMLEATHRDDSQVNAADFFRVAEFPQPCISVLLSGIDKKRMTTDSSKDAAYKSRCIHLRGPFSQPVKEYPDRQQKIPWSPRRFTYGGRRFVWKQGDPNDDAMPETLYEYQKDWAKPGSRTGKRCDDAKPIKLVWGEKRRKGKVDSYTIHFRGGMDQVFREILLASQMARQVCLFTAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2RK19</accession>
    <name>M2RK19_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_168276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696796.1">
        <property type="nucleotide sequence ID" value="XM_007698606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RK19"/>
    <dbReference type="STRING" id="665912.M2RK19"/>
    <dbReference type="GeneID" id="19132567"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_168276"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OMA" id="KPRRDEF"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="180"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD67034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="313" mass="33217" checksum="4144167FCD0C116B" modified="2013-05-01" version="1">MTSATEVSYGFIGLGQMGYGMAQNLRRKTHPASRFIICELDAHRRNQFMEETEGVVEVADTPAAVAEQSDVIITMLPKGAHVLDVFTNLSTGLLSIPKKTTATCFIDCSTIDVETSLQVKEKVFERQAGTFIDAPVSGGPNGARAGALTIMVGGPENAYATALSVLQTFGRSVFHCGPSGAGLATKFINNYLSAITTIGTCEAMNIGLKYGLDPKVLAGVINSSSGRNYNSLEQNPVQGVTPGAASENNFEGGFSVELSKGVLEMSVSLAHQVKAQTLMDEIILRVYTKAVNDSRTAGKDSRSVFKLFIDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2RKE3</accession>
    <name>M2RKE3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_81667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696879.1">
        <property type="nucleotide sequence ID" value="XM_007698689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RKE3"/>
    <dbReference type="STRING" id="665912.M2RKE3"/>
    <dbReference type="GeneID" id="19140847"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_81667"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OMA" id="CRVFASD"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="276" mass="30626" checksum="70C59197699F7060" modified="2013-05-01" version="1">MATRHKTALITGCTPGGIGHELALEFLRRGFQVFGTVRSEEAKKTLVSEGVIAIQLEVTSDASIRALHDEICERVDGKLDILVNNVGVSHTVPVLDLTIEDMRKVFEINVFSCIRLVQTFAPLLIQAEGIIANIGSVAGIVPYVFGGCYNASKAALHSYTDALRIEMAPFGVQVVLVVTGGVKSRISDVKKRLPPNSLYMPIEKDYLFRQGNSQRTAMPTETYARKVVSDLLEPTSKAWLWRGHQSSLVRWLSWLLPRGFWDLYFSRKFGLGKLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2RLN5</accession>
    <name>M2RLN5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_82392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697179.1">
        <property type="nucleotide sequence ID" value="XM_007698989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RLN5"/>
    <dbReference type="STRING" id="665912.M2RLN5"/>
    <dbReference type="GeneID" id="19140890"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82392"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="OMA" id="NGEQYVH"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="62"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="275"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD67549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="508" mass="55647" checksum="A79A8A5DA8A115A7" modified="2013-05-01" version="1">MENTQPTPDTSVDVRQMYSTAAGDAAPKPFSELKDRLHPGLLDGLDKMGFQYMSPVQQKVLTELPSLSSDCVVQAKTGTGKTVAFLLPAIQNLLAGNMPPRGKVAILVICPTRELALQIAKECNGVTACLPQKMECHTAFGGTSRASNLKAFMNGNPTVLVATPGRLDDILGEEEVRDKFSHLKTVVLDEADQMLDAGFAPAVKKILRRIPPKNDGWQGMCFSATLPKEVLDIAKIVLFPGYTHLSTVDPNEVPTHERVPQFYITVPTVGQTFPALSALIEEEHNQNPTDFKAIVFGTTANGVGLLYDLYRNALPQFRLFELHSRMSQPARTKTTKDFKEASSGILFASDVVGRGMDFPNVGLVIQVGLPSSTEQYVHRVGRTARAGKDGRAVIILFEQESFFPRVNKTLPIQPYPVDIVSRLAAHQPKIERAFVDVEEVSKSKAYQAFLGYNKTFVKKLQLSTAELVKLANEYAYTMGCPEPPMLEKSTVGKMGLKGVPGLRIGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2RLZ6</accession>
    <name>M2RLZ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_111604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697244.1">
        <property type="nucleotide sequence ID" value="XM_007699054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RLZ6"/>
    <dbReference type="STRING" id="665912.M2RLZ6"/>
    <dbReference type="GeneID" id="19130159"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_111604"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="261" mass="29907" checksum="E72CABDF030E5FD6" modified="2013-05-01" version="1">MSWTGFKKGVNRATTQVLMKTGQVERTNDRDFETEQRRYRTMETAANKLQKEAKGYLDSLRAMTASQMRIAETIDAFYGDAGTKDGVSRSYKQAVTDLDAETIKALDGPYRTTVLDPIQRFCSYFPDINACITKREHKQMDYDRMRAQVRKLTDKPDKDVTKLPRAEKDEQLAKAAYDQLNDTLTAELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDANTRDQYAQGELDARVEEVLQEIRDLSIAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2RN31</accession>
    <name>M2RN31_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4 beta-hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_62476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695648.1">
        <property type="nucleotide sequence ID" value="XM_007697458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RN31"/>
    <dbReference type="STRING" id="665912.M2RN31"/>
    <dbReference type="GeneID" id="19140397"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_62476"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003639_1_2_1"/>
    <dbReference type="OMA" id="IPEWLMS"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRL6</accession>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OMA" id="CWTENTP"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    </dbReference>
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        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="119" mass="13004" checksum="F5846CF018035041" modified="2013-05-01" version="1">MAKLLLKAPSIQLDSKDRHGRTPLSWAAASGNIEMVKSLLGASNVNVNSQDNNGRTPLSWAASSNSYDIVQVLLRMPDTDANLKDHDGRTPLSWAIRSAGQGTIEALKRQTDSRRFMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RTH1</accession>
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        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
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    <organism evidence="8 9">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
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        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
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        <property type="nucleotide sequence ID" value="XM_007696887.1"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_75809"/>
    <dbReference type="eggNOG" id="ENOG502SKAA">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_1"/>
    <dbReference type="OMA" id="WNSNMYL"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="91"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="345" mass="38662" checksum="9619119AE6362946" modified="2013-05-01" version="1">MRRSLHLAPPYLVDDYIPRYHLLSSVDASKKRSLAYAHLRECNLCPRLCGVNRYEKTGVCLIGAETVKVGTIAPHFGEEPFIQGHNGSGSVFFSGCNLRCVFCQNHDISHTRNGFDLTPEGLADWYMKLQDVGRVHNINLVTPEHVVSQVVLSILHARELGLRLPIIYNTSAFDSLESISLLDGLVDIYMPDFKVWRDTTSRRLLKADKYTEVAMESIKAMHKQVGDLCFSADGIAKKGVIVRHLVMPGMEDEGQEIVRWLAQNVSKDLMVHIMEQYFPRAHVGKPRRGRANSDGEPSSDTGEPVRYADINRPVHLDAVASVKKAAQEAGLWRFVEASRHGGFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2RTY6</accession>
    <name>M2RTY6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_103295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705714.1">
        <property type="nucleotide sequence ID" value="XM_007707524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RTY6"/>
    <dbReference type="STRING" id="665912.M2RTY6"/>
    <dbReference type="GeneID" id="19129836"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103295"/>
    <dbReference type="eggNOG" id="ENOG502TDDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_819257_0_0_1"/>
    <dbReference type="OMA" id="IWRANAC"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="337" mass="37834" checksum="805CD766DC8653D3" modified="2013-05-01" version="1">MERFINTQLHPVDACSICTEPFSTTHQPVALPCQHIFGHNCIKKWLTSGRGNTNACPTCRHILVPKPNPRGSFNVNSIWQELCHQPNERLQVFMQKLWSGLQTLWKNHPKGTFSVTSILNQAIIPALTHTIRTTHPSPGQPPDPILDCYNLISASWDSLGRPDIATGLAIPLVRLARLTANAGAVLPKWLTTSSRTNRLIWRANACLPLNSDHISWDFIMQAAAPASVRYFELLHLYTVLISQGIAHFPVPQPYPTRRHEVVNLVVERCCSKIGGGGCAWRGRPSSEFKDTLGGVYEELRRWQGEKGRMSLRGNYEEEGVVRGVWALAAWSKERVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUF3</accession>
    <name>M2RUF3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_156323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695314.1">
        <property type="nucleotide sequence ID" value="XM_007697124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUF3"/>
    <dbReference type="GeneID" id="19131751"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156323"/>
    <dbReference type="HOGENOM" id="CLU_1366029_0_0_1"/>
    <dbReference type="OMA" id="REQHAKI"/>
    <dbReference type="OrthoDB" id="3685768at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD70204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="221" mass="25789" checksum="B736D07DA8218B88" modified="2013-05-01" version="1">MPESATNLTSFAPEEYSDGWTYEQIAARYISLCAEYLAVHTLFDGVIAARPFERESTIHNLQNARLRLENERQHLHTQIRQLERANQTNRNTNRDLRQQYTEMQETLNIVLQAQFQGDQEAREQHAKIERLEEENKSLQWQIQMLVKARDEDVGSPTGLWNKGEELQSGVNEMGKTVENPDGWVDEVVAEQEKMTKAKISEEQSCWDDNEDDDYNDDHFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2RYE7</accession>
    <name>M2RYE7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_100165</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704307.1">
        <property type="nucleotide sequence ID" value="XM_007706117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RYE7"/>
    <dbReference type="STRING" id="665912.M2RYE7"/>
    <dbReference type="GeneID" id="19129682"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_100165"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_1_1_1"/>
    <dbReference type="OMA" id="GRGWDYK"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="15"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="352"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD60073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="449" mass="50778" checksum="3C6038B2B4DF9F10" modified="2013-05-01" version="1">MASGSTSSNVVGVHYRVGKKIGEGSFGVIFEGTNLLNQQQVAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCNRKFSIKTVVMVAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGSKSANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTPIKDLCDGFPEEFNKYLSYVRNLGFEDTPDYDYLRELFTQALKSTGEIEDGEYDWMKLNNGKGWEAMKSHPSAVQAMHHSNVNPNSSMAVNLQGQQHRQQKTHLPIDHHRLNEPLPKPGATRAQQGRSPRENMNRDSQIKRKSMGELAPPEGASTQAQFQHSQQNLSQNRAAPASSPTPQQPRQQSPEKPSFMQKLANALCCGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2S1C7</accession>
    <name>M2S1C7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_238811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703388.1">
        <property type="nucleotide sequence ID" value="XM_007705198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S1C7"/>
    <dbReference type="GeneID" id="19134943"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_238811"/>
    <dbReference type="eggNOG" id="ENOG502S1TN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058864_0_0_1"/>
    <dbReference type="OMA" id="WGWNYTN"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024571" description="DUF7137 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="142"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="312" mass="33499" checksum="5A5F14C5A5E1E4E5" modified="2013-05-01" version="1">MRPARILAAVVAMSSVTHAISDAFDNIHGLADVKEVLFGRQDNNNNNNNNNDNNNDKKSSDAPASTPAPKPTGDSNNNDNNDNKSGDNNDNKTSNNNDNKSGDNNDNKTASDPKETGTPTGKASGSKTTKKPTKSTTFDPRLPAGGITMVTPDALAGSQYYKVGDYITFAWNYTSLSVTPTAIDVLASCTANQATYTIAVNMSSAETQVVWNTKETPEGQAPFLTENYKLLIYDSNSTATAPARAGYLGAFSGFTFGMYLPQPYTSLKDGWNCPNCNAALSNLERMTLTTMLFTCGTTVGSLVYFTYQFGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2S1T1</accession>
    <name>M2S1T1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_192947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703489.1">
        <property type="nucleotide sequence ID" value="XM_007705299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S1T1"/>
    <dbReference type="GeneID" id="19133830"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_192947"/>
    <dbReference type="eggNOG" id="ENOG502QS4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="OMA" id="WNKNDMA"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF20">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="46"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD61183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="360" mass="39768" checksum="6B2E7FCD57D75674" modified="2013-05-01" version="1">MPSVERVNAEDEYAASGTRIFGGNATARSRLLEPLVYSGSLDSYKHQDLTPAIGREFEGLQVTDLLQASDAVIKDLAVTVSQRGVVFLRNQDVTPNQMRDLMLRLTELSGCPSSSGLHVHPLTEEGSELGDQISVISSEKQKKGGGLTHQLSDVSRFASAGWHSDITFEPVPSDYAMLKIHTLPATGGDTLWASGYEIYDRLSPAMRTFLEGLTATHDAKFFLDEAERLGNPLRKGVRGNPLNYGDALTAVHPVIRTNPVTGWKSVYVNKGFTKRINGITKDESDLLLPYLFNLVTQNHDAQVRFKWNKNDLAIWDNRSTWHCATYDYVEARAGDRVASLGEAPYLDLGSRGRREALEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2S452</accession>
    <name>M2S452_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_95556</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702312.1">
        <property type="nucleotide sequence ID" value="XM_007704122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S452"/>
    <dbReference type="STRING" id="665912.M2S452"/>
    <dbReference type="GeneID" id="19141625"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95556"/>
    <dbReference type="eggNOG" id="KOG3189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD61958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="269" mass="30552" checksum="8858BDF950C8A1B8" modified="2013-05-01" version="1">MATAAAVYPPLDQRPVKNTVLLFDVDDTLTKPRQLVSPEMLQMLSELRHKVAIGFVGGSNLAKQQEQLGGAVDVTSLFDYCFAENGLTAIRMGETLASQSFIAWIGEDKYKALTKWILHYIADLDIPIKRGTFIEFRNGMINVSPIGRNASTEERNEYQKYDLEHKIRETMVAKLKEAFPDYGLTYSIGGQISFDVFPTGWDKTYCLRHIEAEKDISGIVYDKIHFFGDKAYEGGNDWEIYSDKRTIGHKVKNPDDTYAQLQELLKSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2S799</accession>
    <name>M2S799_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cation efflux protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_145017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701273.1">
        <property type="nucleotide sequence ID" value="XM_007703083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S799"/>
    <dbReference type="STRING" id="665912.M2S799"/>
    <dbReference type="GeneID" id="19131334"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_145017"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_4_2_1"/>
    <dbReference type="OMA" id="CLFHQHG"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="287"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="363"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD62998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55122" checksum="7B81319ECF905919" modified="2013-05-01" version="1">MGLSKSTRIMILLGIDTAFFFVELIAGYAVHSLALVADSFHMLNDVISLLVGLWAVKVASQKTNSKTYTYGWQRAETLGALINGVFLVALCLSIFLEAIQRFVEPQDVSHPMIILIVGSCGLLSNIVGLFLFHDHGHGHGGHSHSHDEHSHAEEGHSHGAHSHDDHDHDHVVADESSNIAVSVSVKKNKRHSRSQSRNYATLDEIYVHPSSFRNSIIESSRLRDEEADDEEDNVEAEEEPTERTSLLSKSKRNGTHGHSHSNGKSKENQHKDHKHTKPKQQSSGGGHGHSHADLNMRGVFLHVMGDALGNIGVIATALFIWLTDFSWRMYADPAVSLLITVIILLSALPLCKAASRILLQAVPENMSIDDITDDISDLDGIVSCHHLHVWQLSDTKLVASLHVQVDFDFKGQGSARYMELARQIRECLHEYGIHSSTIQPEFCLNSSHDHSAHGSDDSGAEDAGRSSRNPSVRGGPDACLLECPETCGGGKQCCDPGTTGPNGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7U2</accession>
    <name>M2S7U2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">pectin lyase</fullName>
            <ecNumber evidence="10">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_350939</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="10"/>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705915.1">
        <property type="nucleotide sequence ID" value="XM_007707725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7U2"/>
    <dbReference type="GeneID" id="19138058"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_350939"/>
    <dbReference type="eggNOG" id="ENOG502QXM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021980_0_1_1"/>
    <dbReference type="OMA" id="DWCGSYP"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF67">
        <property type="entry name" value="PECTIN LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025318" description="pectin lyase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="13">
        <location>
            <begin position="102"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD58470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="385" mass="39781" checksum="2559F3F2B047B82B" modified="2013-05-01" version="1">MKLSILALATAYTANAAVVGERQAYGVKGSPEGFGKGTTGGGNAACQIPSSVAQLKTWLTDSTARCIVLDREFNFKGTEGTTTATGCRPASNKCPGNGGQDAINNANWCTNGNAGAGATSIQVKYDNAGTSAINLGSNKSIIGVGNRGVIRGKGLRIANGAKNIIIQNIHITELNPQYIWGGDAITLDGADLVWVDHCKISLIGRQMFVAGYGASNRVTVSNTEFDGSTSWSATCNGRHYWTMLLIGSNDLITLKGNYIHHTSGRSPKVGGNTLLHAVNNYFYSNTGHAFDNEKGGKIVAEGNVFQNVATPLLANTGQFFASPSTSANAACQQYLGHACQLNSFGSSGSLSGSDTSFFSNFGGKNVAGASAASANVANTAGVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M2S802</accession>
    <name>M2S802_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_165419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705689.1">
        <property type="nucleotide sequence ID" value="XM_007707499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S802"/>
    <dbReference type="GeneID" id="19132387"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_165419"/>
    <dbReference type="eggNOG" id="ENOG502QYNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007604_0_0_1"/>
    <dbReference type="OMA" id="CIHSVLP"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="752"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="782" mass="86802" checksum="315F936ABE0CBE64" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2S895</accession>
    <name>M2S895_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_260549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
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            <end position="503"/>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63643.1"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_358132"/>
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    <dbReference type="OrthoDB" id="6132182at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
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        <property type="entry name" value="Di-copper_centre_dom_sf"/>
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        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
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    </dbReference>
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        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD63643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="391" mass="42446" checksum="77D8C403CE038846" modified="2013-05-01" version="1">MKISTYLGIALAGSTSAKFMENDHLAAEGMTKLAIHLTKNGIPSPGTCTLDKVSVRREWATLSRKERIAFTDAVNCLHKLPARTPASVAPGAKSRYDDLVVTHIQQSLTIHGTGNFLTWHRYFTWVFEQMIRKECGYKGTFPYYNWAHYASDPKSGPFFDGSASSMSGDGSYVPGRNSSCFPWDGIAGPCYMHLAPGSGGGCVTSGPFKDFKINMGPLQTMLQLPGGGLPKNPQANGLGYNPRCLRRDISLQAANATTDSEVVRLINNYTDIATFQREYQGAFAEGRMGVHTGGHYTIGGDAGSDFYNSPADPAFYPHHGMIDRVWWTWQNLDLKNRERALAGSAGGIGDTTAKNATLGDALSVGEYVGYPNITIRDAMSTVGGPFCYIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SA26</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="289" mass="30549" checksum="B50C76E09DB4CA10" modified="2013-05-01" version="1">MPSPPKTSLSSSSPPTAPWKPARLDEYLSLSHAPNAKATSSIVKPLSIKVDSGPNGSVPGFLHLPPATSSTPATSTGVIFLSGAGGGVVGPSAMYLSLAEKLASLPRPMAALRLDYRYPACTAHCVRDVLAAMRELQDTYHMSSFVLVGWSFGGAPVFTVAGQDERVVGCVGIASQTADTDGIQFLAPRPVLLIHGTGDRTLGHSCSERLYEAYGRGGKRELRLCEGDDHALTRSSREAEQVVGGFVLECAGLEVRGNGRGMGEVLVGEEEKVELMWKGGDLRGEERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB28</accession>
    <name>M2SB28_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_90265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700273.1">
        <property type="nucleotide sequence ID" value="XM_007702083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SB28"/>
    <dbReference type="STRING" id="665912.M2SB28"/>
    <dbReference type="GeneID" id="19141341"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90265"/>
    <dbReference type="eggNOG" id="ENOG502RYAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010112_0_1_1"/>
    <dbReference type="OMA" id="FMYNAVL"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025613" description="DUF6536 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD64513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="586" mass="66784" checksum="93208B412239C374" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEK8</accession>
    <name>M2SEK8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_35744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698390.1">
        <property type="nucleotide sequence ID" value="XM_007700200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SEK8"/>
    <dbReference type="STRING" id="665912.M2SEK8"/>
    <dbReference type="GeneID" id="19138500"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35744"/>
    <dbReference type="HOGENOM" id="CLU_2704641_0_0_1"/>
    <dbReference type="OrthoDB" id="3439209at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8529" checksum="3B314121DB7736AC" modified="2013-05-01" version="1">MLLQTDLLNETVWQELKRIESNLQNPSALSIEQKLMKVSWKKVADYIEENGGSYHFGNSTCKRKWLELNPTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SET6</accession>
    <name>M2SET6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_97445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703334.1">
        <property type="nucleotide sequence ID" value="XM_007705144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SET6"/>
    <dbReference type="STRING" id="665912.M2SET6"/>
    <dbReference type="GeneID" id="19141732"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_97445"/>
    <dbReference type="eggNOG" id="KOG3113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048955_3_0_1"/>
    <dbReference type="OMA" id="EFRWLHC"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="332" mass="35887" checksum="B9816193ED06C333" modified="2013-05-01" version="1">MGNDGGSIPKRRELVKEAAKALTTAQIKEAQTEQQEYAWSTDPLTRKPLARPVVSDAAGILYNKDSIIEYLLKDDSDVEKAEMKKIGGVKDSELGTFGDRVKGLKDVVEIKFEIDTAAESGAGEKWKCPITGERLGAGSKAVYIVPCGHAFAGSVMKEISEKTCLTCNEPYAENDVVPILPTAPTDIARLNLRLKTLREKGLTHALKKAPGSKKKRKHASAADDDTQATTTTTTTTTSAPTKPSSSSDEDKKTKPKENGTTAKAVSAKSDGIKNSATASLTRKVLQEQEERNKRRKMAQNENVNSLFSKKEHKAAAGNSADFMTRGFSIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SG48</accession>
    <name>M2SG48_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_39148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702579.1">
        <property type="nucleotide sequence ID" value="XM_007704389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SG48"/>
    <dbReference type="GeneID" id="19139427"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39148"/>
    <dbReference type="eggNOG" id="ENOG502S4VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042937_1_0_1"/>
    <dbReference type="OMA" id="KKSTQHR"/>
    <dbReference type="OrthoDB" id="3925971at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="282" mass="32562" checksum="1171012EFA16B763" modified="2013-05-01" version="1">MPRFLEPKKSTQHRVAAIALYRALLLRCSSAPLSNDDRVSLRNAVRNKFRRNRKIQSPYQLGLSFKAGYETLDHLDASTAGDAASTSILMRMVAQLPRALIRAPPVRRTEDRASNEPKERLACLPPEKAVLNVRPYPKTSGPRHVPIMSSANGIPFLRLTKPQPPALSRVLRQRLQRKIQLFDTKVLLSNWWLPMCEEEDAWDALINAQLQTREDDVKWTDAIRQSEWLNQEAYKKDMRKDREITKKMQNIVDLETKMALEEGQTIVRGRRRRPIQVIKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHU4</accession>
    <name>M2SHU4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_226390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702324.1">
        <property type="nucleotide sequence ID" value="XM_007704134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SHU4"/>
    <dbReference type="STRING" id="665912.M2SHU4"/>
    <dbReference type="GeneID" id="19134685"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_226390"/>
    <dbReference type="eggNOG" id="KOG1946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046065_1_1_1"/>
    <dbReference type="OMA" id="KVWQYIR"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="283" mass="31393" checksum="BB3CF1776F221584" modified="2013-05-01" version="1">MSDPLPAEVEASYSVIIDDILRASDINTISAKRIRKGIQERVGEDLSHQKEQITTLIMQRFDKFNSEQNGGSDVSEPTNTVRNGTKTSNGDTSDMSNHKRSPPDDESVLSGPDENPPPKKKNKKTKVKDEDDDAAFAARLQAEENARMGRATRGGNTKRKAPAPKKKAKKKSANKVKDDDDSDVGSGSGGEKKSPSRKGGFHKPMALSPALSELLGETQLSRPQTVKKIWEYVKARDLQDPNDKRQIRCDDAMRAVFKQDRVHMFTMNKILNQNLYAVDEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIF4</accession>
    <name>M2SIF4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1294 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_283644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696756.1">
        <property type="nucleotide sequence ID" value="XM_007698566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SIF4"/>
    <dbReference type="GeneID" id="19135851"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_283644"/>
    <dbReference type="eggNOG" id="ENOG502SE23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091970_1_0_1"/>
    <dbReference type="OMA" id="DKMQARN"/>
    <dbReference type="OrthoDB" id="10259680at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010718">
        <property type="entry name" value="DUF1294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06961">
        <property type="entry name" value="DUF1294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14863" checksum="5F7EDB84FDE2FF98" modified="2013-05-01" version="1">MVPRARPRHRPWTVATLAGVASLLLPAATLMRLYALSRFPLYAVMYAGAISGVTFLFYGYDKMQARNMEWRVKETTLQTLALVGGWPGALAGMHYFQHKTKKVAFQVVFWGIVLCWEGVAWLVWSRGATVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKC5</accession>
    <name>M2SKC5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_34417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696610.1">
        <property type="nucleotide sequence ID" value="XM_007698420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKC5"/>
    <dbReference type="STRING" id="665912.M2SKC5"/>
    <dbReference type="GeneID" id="19137643"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34417"/>
    <dbReference type="eggNOG" id="ENOG502S5KJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_1_0_1"/>
    <dbReference type="OMA" id="QMAMIRG"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF9">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="194" mass="21569" checksum="E1366E3044A99F01" modified="2013-05-01" version="1">MSDPGADRQKAIAAVRAMFDKYKLLAEKRPKDHIDFDNQVMNSLELVDATTDGTVTYEMFMAPNFSNLNNVMHGGAAGVIFDMSTTTALCPLARPGFWEFMGGVTRSLNISYLKAVPIGVKVRLNSKVVSIGKQMAMIRGDMTSLDGKTTYCTVEHHKVNVPVQPEHRVVRTAWDDEFDREWAAQEKKAAKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKI6</accession>
    <name>M2SKI6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_144678</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701160.1">
        <property type="nucleotide sequence ID" value="XM_007702970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKI6"/>
    <dbReference type="STRING" id="665912.M2SKI6"/>
    <dbReference type="GeneID" id="19131322"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_144678"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OMA" id="YWVPSNS"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="140"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD62830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="294" mass="31416" checksum="3968A089A1E4BD41" modified="2013-05-01" version="1">MASNIRLKMPSTSTLYINDINTSSCTRFKSEYSSHGPIEISASAREAAEKAKYLISIVPDGTDVKKVYLDPGTGHAGLGTYIDAPVSGGVPAAQAGTLSLLIGHPPPSCPTSNPKLSTRLTHILSMLGPASKFFYLSTLGAGLTAKIANNYLSGTILLATAEALALGISHGLDPSVLYSVIKSSTGQSWMCDHVMPVPNVQTEYWVPSNSGYKPGFKTQMMIKDLGLGVQSARQVGTGCSMAEKALEIWEQAARDERCRDRDGSSVYLFVGGKLPEGYEDRGRRGEDGTWEFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SL66</accession>
    <name>M2SL66_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007702836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SL66"/>
    <dbReference type="GeneID" id="19139120"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37894"/>
    <dbReference type="eggNOG" id="ENOG502RYFU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011914_2_0_1"/>
    <dbReference type="OMA" id="PEAIDSC"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="288"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="530" mass="58394" checksum="44570CE3CAE79C3C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SL76</accession>
    <name>M2SL76_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_79901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695682.1">
        <property type="nucleotide sequence ID" value="XM_007697492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SL76"/>
    <dbReference type="GeneID" id="19140755"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_79901"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011715_0_0_1"/>
    <dbReference type="OMA" id="GIWNTES"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="571"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="895" mass="97144" checksum="A8D5EF03498CB0A2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNN8</accession>
    <name>M2SNN8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_41896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705805.1">
        <property type="nucleotide sequence ID" value="XM_007707615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNN8"/>
    <dbReference type="STRING" id="665912.M2SNN8"/>
    <dbReference type="GeneID" id="19140110"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41896"/>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114688_0_0_1"/>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18230" checksum="A42A7CC6613FE2AA" modified="2013-05-01" version="1">MVLALALKAELNGVTDLRPNDTEEAPFFYTFKVQCTSCREIHPNFVTVNRFEMNEQSGSKGEANFVWKCKNCKREHSANVKAAPASYPQSDPPKMVNILEFDCRGLEFTEFKAEGEFLATGIESGTKFSGIELPDGEWYDYDEKAGEEVSITNVQWEIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP92</accession>
    <name>M2SP92_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_181272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699987.1">
        <property type="nucleotide sequence ID" value="XM_007701797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP92"/>
    <dbReference type="STRING" id="665912.M2SP92"/>
    <dbReference type="GeneID" id="19133299"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_181272"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_0_0_1"/>
    <dbReference type="OMA" id="EHRWDKH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="44"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD64100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="648" mass="70805" checksum="32FDB69658E11C02" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQG6</accession>
    <name>M2SQG6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_41230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704885.1">
        <property type="nucleotide sequence ID" value="XM_007706695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQG6"/>
    <dbReference type="GeneID" id="19139943"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41230"/>
    <dbReference type="eggNOG" id="ENOG502SQRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064113_0_0_1"/>
    <dbReference type="OMA" id="GGWLCEM"/>
    <dbReference type="OrthoDB" id="5350391at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF3">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025692" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="161"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="280" mass="28803" checksum="E80B38D84F79E2FE" modified="2013-05-01" version="1">MRSSIAISIAALAGSALAAPSYPAAYPAAYPADKPAPAANPNVEVVVEHVVHTVYVTEGSPEATPCPSSTPAATPAPAATPAPEAYPAEQPKPAPSSTLSSVVYVEATPSPYPEAPVEQPEPAPEPTPTPTPTPAPAPEPTPTPTPSPSPAPAPATGGYMDVVAEWRAKLGLSKLEFSAELESNALNVVIEGAGVMKHKLNSGTYGQVLAPGDADKFEYVFVGGWLCEMANLPGLGNACQEFSKGWDYQGQTGHAEILTSPNYSKIGCSNKEGIWCCDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQH2</accession>
    <name>M2SQH2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_106077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694803.1">
        <property type="nucleotide sequence ID" value="XM_007696613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQH2"/>
    <dbReference type="STRING" id="665912.M2SQH2"/>
    <dbReference type="GeneID" id="19129987"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_106077"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OMA" id="NWYGFNV"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD69493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="492" mass="52517" checksum="13C832E2345CE8A0" modified="2013-05-01" version="1">MATIKLVKPDPSYTVPLLINGQEVTTTTTFPVISPSSHKELWRASSASPADVTSAVAAAKSAFPAWSKMKHSAKRNIFLKAATVIEARADEFADYMKLETGAADMFANGFNVPKMADMLRDVAGRLSGVMGHIPSCEEEGTSALIVKEPFGVVLGIAPWNAPYVLGMRSVLYPLAAGNTCILKGSELCPRTWWAIGSALSEAGLPAGALNVLFHRPEDAAQITTALIEEPAIKKINFTGSTAVGRIIASTAGKNLKPVLLELGGKASAIVLDDANLQTAAVQCALGAFLHAGQICMSSERILVHKDIKPQFIEAFKGAVEGIFGGDKPAPILIAAPGVEKNKKLIADAVKNGAKVVQGDYEKDEKHPETNETSATRMRPVIVDGVNKNMELFHTESFGPSVSVIEISSDEEAIEIANDTDYGLSGAVFTENLGRGLRIAKQIESGAIHINSMTVHDEWTLPHGGAKASGFGRFNGHWGIEEFLRLKTITYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQN5</accession>
    <name>M2SQN5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_263112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705493.1">
        <property type="nucleotide sequence ID" value="XM_007707303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQN5"/>
    <dbReference type="STRING" id="665912.M2SQN5"/>
    <dbReference type="GeneID" id="19135474"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_263112"/>
    <dbReference type="eggNOG" id="ENOG502SRWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647206_0_0_1"/>
    <dbReference type="OMA" id="AANNTWV"/>
    <dbReference type="OrthoDB" id="5279542at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="52"/>
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        </location>
    </feature>
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            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
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            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD59067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="421" mass="46027" checksum="C5B72F9205540936" modified="2013-05-01" version="1">MSTSQPQVAPPATGAPAASSNTQDSIPQRPAVLSESITRLSTNTNANVNQDTLIGAAGTPSPGPNTTPAAAPQATTADEPLSLNDKLNAGDRYWKFKFAITAVIIITGLVGIGCFAWLMTTRTGGSDYYLLDSYWALWPSLISWSISIAWCLICIVVFVMRKRTVHPGVRVSMELLLWLAFIVTALFALLSLQNIMDYGMYGGPDQWGYDYSSSSSNGDYVLAANNTWVWQEDTSYITSPRDCTSRYSVFSEMNFKDCAEQDAFVNKLWAEKPQRARVNLTGVVCQFFGLVLHFVLFVWACVDTHRRNRTKVSKDAEKLAAGIVQTMIGNGAIIPPPGQAHVQPGMGQRMYYQAPPQGYPVQPVYMQQAPGQQPQFAMPQQMGQQGYMVPMQYHPGQQNTGAPRVGVAGPSNEKGAGPRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQT3</accession>
    <name>M2SQT3_COCSN</name>
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        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="17" type="ORF">COCSADRAFT_259046</name>
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    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705173.1">
        <property type="nucleotide sequence ID" value="XM_007706983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQT3"/>
    <dbReference type="STRING" id="665912.M2SQT3"/>
    <dbReference type="GeneID" id="19135400"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_259046"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="400"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="464"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD59476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="740" mass="85205" checksum="444DBE9387E678FF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRQ6</accession>
    <name>M2SRQ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_40931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704521.1">
        <property type="nucleotide sequence ID" value="XM_007706331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRQ6"/>
    <dbReference type="STRING" id="665912.M2SRQ6"/>
    <dbReference type="GeneID" id="19139868"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40931"/>
    <dbReference type="eggNOG" id="KOG1772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125101_0_0_1"/>
    <dbReference type="OMA" id="ARKYRQD"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.620:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="F1F0 ATP synthase subunit B, membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="114" mass="12968" checksum="655B86B8CA576C60" modified="2013-05-01" version="1">MSAQNSAGIQTLLDAEREAQKIVQQAREYRTKRVKDARNEAQKEIDDYRNEKEAEYQKFEKEHSSGNQKAEEDAKKDTDAKIKEIEEIGNKSGAKVVDQLIEAVISAHPEPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRU0</accession>
    <name>M2SRU0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_40718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704470.1">
        <property type="nucleotide sequence ID" value="XM_007706280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRU0"/>
    <dbReference type="STRING" id="665912.M2SRU0"/>
    <dbReference type="GeneID" id="19139817"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40718"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_0_1"/>
    <dbReference type="OMA" id="MQSKPYA"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026071" description="CN hydrolase domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="297" mass="32842" checksum="D3D875B1FEDC4C63" modified="2013-05-01" version="1">MTLILKKSLKLALVQLASGADKAANLTSARQKVLEASKAGAKLVVLPECFNSPYGTKYFDKYAETLRPSPPSESQSQTFHALSKLARDAGVYLVGGSIPERDEQDEKKLYNTSLTFAPSGELIATHRKVHLFDIDIPGKIRFKESEVLSPGNKITLVELPEYGKIAIAICYDIRFPELAMIAARKGAFLLLYPGAFNLTTGALHWELLARARATDNQVYVGLCSPARDMSAEYNAWGHSMVVDPNAQVMEQLDEKQGVLMQELEAGKIEEVRKGVPLYGQRRFDVYPDVSEGGRFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS72</accession>
    <name>M2SS72_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_347253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_347253"/>
    <dbReference type="HOGENOM" id="CLU_1234896_0_0_1"/>
    <dbReference type="OMA" id="HRDDEMR"/>
    <dbReference type="OrthoDB" id="3690105at2759"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="206" mass="24079" checksum="FB077593FF7B482F" modified="2013-05-01" version="1">MDGLQTLQQESSVSQMFNQTGKHTYHTFQTNELLSTYSIKDLNRLVHGPNIHAINWTPAVTNVHTGATTTVRHHCSQGSHGWYRCGLQQMVMSTACKKHRDDEMRKVFDKLRKGYPVYGWELNRPDREESNVCSETKMEAIVEASKAEEEELEKQIEERGEVDESVFVYAQMKKREEAQMKERMWQRKDEKERARLGKQGISEREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_76096</name>
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    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSP7"/>
    <dbReference type="GeneID" id="19140545"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_76096"/>
    <dbReference type="HOGENOM" id="CLU_213569_0_0_1"/>
    <dbReference type="OrthoDB" id="3563554at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD70243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="6495" checksum="07B655E83B159E09" modified="2013-05-01" version="1" fragment="single">AYEVTKVLVLEYRIPKEFITNYDKLFTSKYWSIFLVKLGVKKKLLISFYLEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2STP9</accession>
    <name>M2STP9_COCSN</name>
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            <fullName evidence="5">DOA4-independent degradation protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_150403</name>
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    <organism evidence="3 4">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703814.1">
        <property type="nucleotide sequence ID" value="XM_007705624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STP9"/>
    <dbReference type="STRING" id="665912.M2STP9"/>
    <dbReference type="GeneID" id="19131532"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_150403"/>
    <dbReference type="eggNOG" id="KOG3230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="OMA" id="KMAKMNQ"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25504" checksum="42E426808A08259C" modified="2013-05-01" version="1">MNIVEWAFGKRMTPAERLRKHQRALEKTQRELDRERVKLENQEKKLVADIKKSAKNGQMGPLRIQAKDLVRTRRYIQKFYQMRTQLQAISLRIQTVRSNEQMMQSMKGATTLLGSMNRQMNLPALQRIAMEFEKENDIMDQRQEMMDDAIDDATGMEDEEESEDVVNQVLDEIGIDLGQALGETPSGLQKNTVPETRVAQAVGGGGADPDDDDLQARLDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUF1</accession>
    <name>M2SUF1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_99331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703979.1">
        <property type="nucleotide sequence ID" value="XM_007705789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUF1"/>
    <dbReference type="GeneID" id="19141848"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99331"/>
    <dbReference type="eggNOG" id="ENOG502SF5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105974_1_0_1"/>
    <dbReference type="OMA" id="LAWCASD"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="20558" checksum="F13373A9875C226C" modified="2013-05-01" version="1">MDNILTQKTPMGMVVAQTVGITVSMFLFGSNTCLSLVGIPTAMEAPAPLAVKQWYSIFTRGGAIARPLAMLSALATGYVAYNQDSSSTAFRLNLASTILLPSIVPFTLLVIAPTNAKLMAKKEELESASLEDKAIEANAAQGETVHELMDRWATLNMARTLLVGVGALCTVLAAASKREVVKLGGMAIKSGANRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SV16</accession>
    <name>M2SV16_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_137372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697685.1">
        <property type="nucleotide sequence ID" value="XM_007699495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SV16"/>
    <dbReference type="STRING" id="665912.M2SV16"/>
    <dbReference type="GeneID" id="19131049"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137372"/>
    <dbReference type="HOGENOM" id="CLU_1031199_0_0_1"/>
    <dbReference type="OMA" id="NIGYREW"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="234" mass="25610" checksum="CA1A62E8D3C08C31" modified="2013-05-01" version="1">MANSLKEKSLYSELRAASITIGIPTPSTVSVTATLPRSPESTGPPPTPIATRGTHGDCEAQPSGYGPIPKYDKMRGFYYSPEIRHAAENAPIPPGYIESFVSANGSFVGSHYLGHYELKSFDTLEGTEPGHDQICQGFNTYFERAPAIRLGPECRESTSRTIIKCALWGEPLRIEGAKNIGYREWEFDVVIAGSNGYSLEKYAESRNLAPGKKLDHMVLATLFALQVFLGFMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX21</accession>
    <name>M2SX21_COCSN</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_35333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697635.1">
        <property type="nucleotide sequence ID" value="XM_007699445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX21"/>
    <dbReference type="STRING" id="665912.M2SX21"/>
    <dbReference type="GeneID" id="19138226"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35333"/>
    <dbReference type="eggNOG" id="ENOG502RHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="OMA" id="YKPAVVW"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD66860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="344" mass="36227" checksum="9B13DD6733AE2E88" modified="2013-05-01" version="1">MSTLNSHLPWTSSPLLINAPMFGFAGGHLAATVSLAGGLGLIGGVRDMHEVRRELDIAAELLGHTRGEGTMRVGVGFLQFAMEMAEVLDVVREYKPAVVWLFASKTLAGYKEWVDGVRGVSPESRVWVQLGSVAAALEVAKGARPDVLCLQGADAGGHGFEKGASIVSLLPEAADALGAAGFADIALVASGGIVDGRGVAAALALGAQGVVMGTRFLASREVKIHPKYQAAILEAQDGGQVTTRSKLFDQLRGPNIWPELYDGRGLAAQSHKDFASGMSLEEIQRLHNQEAASENKGYDTGLQGRAAIWAGTGVGLVNQVQSARDIVEKIRKETKDVLLRVANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXH8</accession>
    <name>M2SXH8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_157460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696784.1">
        <property type="nucleotide sequence ID" value="XM_007698594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXH8"/>
    <dbReference type="STRING" id="665912.M2SXH8"/>
    <dbReference type="GeneID" id="19131825"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157460"/>
    <dbReference type="HOGENOM" id="CLU_000288_138_5_1"/>
    <dbReference type="OMA" id="FCANQAK"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="176" mass="20082" checksum="C01A89AE2924A1A7" modified="2013-05-01" version="1">MRLLKSRTDDSFSPTWFAPSSTPNYVTLSHRWEGDDQEITLQDLKDGSAKGKLGYSKVRFCANQAKNDGLEYIWVGSCCIDKSNNSELAEAIISMFRWYRNAAKCYVYLGDVPSKHNSWLSDFEKSQWSKRGNVEFYAKDGQLLGTKFTLQDHIHNITGIERSVLQGDNMSTFSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXV1</accession>
    <name>M2SXV1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_178870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696876.1">
        <property type="nucleotide sequence ID" value="XM_007698686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXV1"/>
    <dbReference type="STRING" id="665912.M2SXV1"/>
    <dbReference type="GeneID" id="19133163"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_178870"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_1_4_1"/>
    <dbReference type="OMA" id="CHTHMKK"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="356" mass="38744" checksum="96C1BC0B02689D2B" modified="2013-05-01" version="1">MSVNVIDVGVSRISGAREHQEDRYITLLPGSIKSRKDLAIFAVYDGHGGTEVVNHVAQHLHTHLEQHLTHPKASSVAEYKHAIQCALKAVDRELDQADLHGGSTVTLVLVDTKQNLLIQANLGDSHCYYAEHEARSPQLLSPNSPARSDSSMGWNVEALSVEHTPDSPLEKRRIEESGGAINYTSGIARIGGVSMSRALGDLDLKKPRVNRLAGHDLSDLVGVETGLAPGKAAKHDLVSNKAHFSVRTLNGQSLILLASDGVGGAHEAEAATQLAVDRWQQGKDAKEIAEELTQKESQMKGADNCTVVVVVLDTENKGRRSIDSGRRSFDISSERSSSRRRRRSSITSLKDWIRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXV8</accession>
    <name>M2SXV8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_146855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702192.1">
        <property type="nucleotide sequence ID" value="XM_007704002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXV8"/>
    <dbReference type="GeneID" id="19131390"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_146855"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075838_0_0_1"/>
    <dbReference type="OMA" id="NQHMNAL"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF356">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD61791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="275" mass="31677" checksum="E85CF8546BE15159" modified="2013-05-01" version="1">MYYGNECEMCDREFGSQQAAIQHMDALDHWASRFECDTCDREFFTQRSADQHMDDKGHWEPQFGCETCDKRFRSQLYANQHMNALNHYKRHCCCDCAKTFQSENALRMHLNSSSHRGKNVACPLCKTAFTSASGLSHHLETSSCPQAGNLNYRTIFQAISLRDCNGLLTNKLLTYPDFGTQNVASSAAWNDSNYECYLCHREYNTLQALNQHLNSPAHSEKLYHCPNRSCNHQFSCLASLFNHLESESCKFVRFEKVQKQVPNFITGQQKFIGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY98</accession>
    <name>M2SY98_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_162326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702185.1">
        <property type="nucleotide sequence ID" value="XM_007703995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY98"/>
    <dbReference type="STRING" id="665912.M2SY98"/>
    <dbReference type="GeneID" id="19132172"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_162326"/>
    <dbReference type="HOGENOM" id="CLU_1240025_0_0_1"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="115"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="223" mass="23877" checksum="47C8C1FCA20F3AAA" modified="2013-05-01" version="1">MSGKVGMDWFPLLPGHEVVCAVVQVPEEAALWGFKVGDLTKAKGVHIAGFFSEYTTLDAASTVLISRNFGVNTPLKGLDKPLCPIFCAGITIWDGLEQTKLGVSESVGVVGAGDLGQLATAFLTILGHKVVVMDVQEKQLVACKEEYPGVETINSDNCSDLATKLREVNDGNLLNVAFVTSGVKAAYDSTLPLLEPYGKLIVIGHPPKPLEISAYMMSDKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYN8</accession>
    <name>M2SYN8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_183068</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702281.1">
        <property type="nucleotide sequence ID" value="XM_007704091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYN8"/>
    <dbReference type="STRING" id="665912.M2SYN8"/>
    <dbReference type="GeneID" id="19133394"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_183068"/>
    <dbReference type="eggNOG" id="KOG0831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023995_3_1_1"/>
    <dbReference type="OMA" id="FWFTCAN"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD61912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="495" mass="55560" checksum="87C92C87DB1E1B4D" modified="2013-05-01" version="1">MSLNPEPSAPEERAEHNLPPKSYADAAEEALQSGPQSHVNGEDRTDEVKTNGIHAASDEEQTSHEGIGQDGSPKSPTARGHRRVSSRSSHKSSKSTQDNQLPKDMIESHTNGNGNALTTVEPSQESELPPRDRRTDLKRRDSELTAGRQAGASWSKSKIRFAPMNVPLQRRLQTLAVLMHTLSIVGSLAIFFFLCSIPLLWPILLPYTVYVLFSDAGTSGELSLRSEWFRRLPVWSLFASYFPARLHRSQELEPTRKYIFGYHPHGIISHGAFAAFATEALGFSQLFPGITNTLLTLDSNFRYPIYREYALRLGMASVSRESCENILSKGGQNGEGMGRAITIVVGGAAESLDARPGEIKLVLRRRKGFVKLAIRTGADLVPVLSFGENDIYDQVDTESHPYIHKFQLLIKKFMGFTVPIFHARGVFNYDVGMMPYRRPINIVVGRPIRVVQNEHPNNDYIDQVHQQYVDELIRIWNEHKDTFARNRTGELEIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0B4</accession>
    <name>M2T0B4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_177911</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695729.1">
        <property type="nucleotide sequence ID" value="XM_007697539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0B4"/>
    <dbReference type="STRING" id="665912.M2T0B4"/>
    <dbReference type="GeneID" id="19133114"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_177911"/>
    <dbReference type="eggNOG" id="KOG2647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029048_0_0_1"/>
    <dbReference type="OMA" id="CEWTLPS"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026286" description="GPI mannosyltransferase 2" evidence="13">
        <location>
            <begin position="32"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD68000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="459" mass="50671" checksum="C65627122D0D6679" modified="2013-05-01" version="1">MKSVSESPGQRSTSRLVSLFCLWKSILLTLAAFCPGPGYDTSGLILLDTSVQRHDHFNVSTRFERFVLNLLRWDALYFVKSADRGLIHEQAWAFSGVYSRLLGITGRSVSGSVAPPLHYYVLAGIIVSNACHLISVLVLHRLLTLILEPQRQKTIPFVAAILHVLTPASLFMCAPYAEAVFSLLNFTGMLLYAQSRAIARSTTFSIQEDIQKVGAGLFFAAATLMRSNGLLSGTILLYDVVRYLFALTSTQRSIHDVRRILVTCISGGLIAIAFIGPQYLAYAEFCNGESGAGIRPWCEKRLPSIYSWVQSHYWNVGLFRYWTVSNLPLFTLAAPTLWLLFTSSVTLLRSCGGDLLCTTPVSGIRVTQDAGSAICKLPELALPQLFLAISAVTTFHVQIVNRIASGYPVWYLMVATWVVDLQVTSSMKNGSSRAQWFVRGMIVYSLVQGVLYANFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1H7</accession>
    <name>M2T1H7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_119676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701189.1">
        <property type="nucleotide sequence ID" value="XM_007702999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1H7"/>
    <dbReference type="GeneID" id="19130420"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_119676"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="OMA" id="HYGPIFN"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026324" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD62877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="63303" checksum="7CD413351D74C69B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2Q0</accession>
    <name>M2T2Q0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_33622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695587.1">
        <property type="nucleotide sequence ID" value="XM_007697397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2Q0"/>
    <dbReference type="STRING" id="665912.M2T2Q0"/>
    <dbReference type="GeneID" id="19137235"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33622"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003502_1_0_1"/>
    <dbReference type="OMA" id="DERAHIP"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="228"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="377"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="525"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="696"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="884"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1076"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1095"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD68750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1207" mass="134765" checksum="368E43DDC236E6E6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3E2</accession>
    <name>M2T3E2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_91110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        </source>
    </evidence>
    <sequence length="474" mass="50262" checksum="7238CE7FD34323E6" modified="2013-05-01" version="1">MPPKQAQKESKPKPAKGQANNNDDTPHGTIPEYEIKQNAGVSASMALQAGQKAWELRQAAHGAADAEAREKILAKAINKEIEAESFGKAAKYTQSGAFQGLAAGAGLGVQPGVTLGKLTGALVGGLVSTVTGLIGGGVGSVYGAMSGPFWDLGEMASHGVQGVVGDFLPDIKASSSQRKALEKMIMQTKETQAPTREELEQMKNDAPDQMPQSWSQSVKDMTSWRPKIPSMPSMPSAKGMGGAVGLGGLGASMNPWGGQKQNQQQQSVPQTQQQQQQSQQKPNPQAPVQNQQPTQQQSQQPSQIQNQRPNPPSRQPSKQGNQQGASSNATPQEEPKSMKPRSQRPSTTRGPANPQSASQPQPSTSNTNSQPTQQKQPPRTQQSSKKPAVSTQTRSSPPKSQTANTPRPTQTKRVSFNDGQESGSTTSTAKARRKPRKLNQQTPNAANDNGIAKASAPPAAKRAPRKLETRKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2T540</accession>
    <name>M2T540_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_87168</name>
        <name evidence="1" type="ORF">COCSADRAFT_89786</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ND90Pr</strain>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698503.1">
        <property type="nucleotide sequence ID" value="XM_007700313.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700183.1">
        <property type="nucleotide sequence ID" value="XM_007701993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T540"/>
    <dbReference type="GeneID" id="19141167"/>
    <dbReference type="GeneID" id="19141316"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_87168"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89786"/>
    <dbReference type="eggNOG" id="ENOG502RQHP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_12_6_1"/>
    <dbReference type="OrthoDB" id="5410741at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9808" checksum="0AD4129A88D27318" modified="2013-05-01" version="1" fragment="single">WPPFSPDLNPIEHLWWALKKKLHELHPEFDYMGDTEREWDQFENGLREAWSAIPDSLITKLISSMPRRLDAVRTAHGYQTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2T566</accession>
    <name>M2T566_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_89203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699998.1">
        <property type="nucleotide sequence ID" value="XM_007701808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T566"/>
    <dbReference type="GeneID" id="19141288"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89203"/>
    <dbReference type="HOGENOM" id="CLU_208796_0_0_1"/>
    <dbReference type="OMA" id="GNYLVCY"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="62" mass="7475" checksum="42831369159DBC77" modified="2013-05-01" version="1" fragment="single">REYISTYIPLYIRTKLIKTLYESLEYRYAGVDEIVRQLAKVFIILRLRAKVQKILGNYLVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5S3</accession>
    <name>M2T5S3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_213859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695009.1">
        <property type="nucleotide sequence ID" value="XM_007696819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5S3"/>
    <dbReference type="GeneID" id="19134455"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_213859"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OMA" id="ICTFRGV"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
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    </feature>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">COCSADRAFT_32517</name>
    </gene>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <dbReference type="PubMed" id="23236275"/>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="entry name" value="His_Phos_1"/>
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        </location>
    </feature>
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        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
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        <location>
            <begin position="485"/>
            <end position="516"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="553"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69935.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62783" checksum="F6C6960EEBE8C7F1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">COCSADRAFT_37121</name>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000016934">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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    <feature type="chain" id="PRO_5004026478" evidence="1">
        <location>
            <begin position="20"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="51" mass="5670" checksum="FAE8DC6D7DA00378" modified="2013-05-01" version="1">MRTTTFLMTLVLLTPTVFARCLLIGPGNGQICFLTVSTLLTYYLVRVNCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6W4</accession>
    <name>M2T6W4_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">COCSADRAFT_36332</name>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64986.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="357" mass="41289" checksum="54A8CD00AB0B3849" modified="2013-05-01" version="1">MESLDDDEDYAAIHLLEARFERIETGASASGDDDDDDNDQATGRPIWSGSHAVFRVDDEWYRQFHRVGGAQDRQGNTIDDADARWSRTLDRLELRRPEEGFGTLRWCIRLDHAVLDLDFPAEADRLHFDVRVNLATRCVRVAWRDMLVRFLKTERALRLMLDEKRTHQRFTFSHAEDCLRDLRRKRLAAALSPHSKVDRHIRWSLRLLHPLFGCPPNEHTMTLENVENDAVHMLLLLRRAASLSAAQVDYLHALARDYRAMEAQLRRLDDAYAEFKSYLTVPGFQMNILLPAMVTNAGHVPRDPVAWTDELREKIECQVERWRGQRDAVEQVGEILEASNEAMGVPDDSFDELGSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7M1</accession>
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        <recommendedName>
            <fullName evidence="7">Nucleoporin</fullName>
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    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_141326</name>
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    <organism evidence="5 6">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701295.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2T7M1"/>
    <dbReference type="GeneID" id="19131200"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_141326"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="OMA" id="WSQMFAE"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD64952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1667" mass="187728" checksum="4D173B4E2109EE49" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9W2</accession>
    <name>M2T9W2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-hydroxyacyl-CoA dehydrogenase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_35946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD66016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698436.1">
        <property type="nucleotide sequence ID" value="XM_007700246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9W2"/>
    <dbReference type="STRING" id="665912.M2T9W2"/>
    <dbReference type="GeneID" id="19138623"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35946"/>
    <dbReference type="eggNOG" id="KOG2305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_0_1_1"/>
    <dbReference type="OMA" id="HRYYTIT"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="181"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD66016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34859" checksum="FB9DB20327096C93" modified="2013-05-01" version="1">MARTEPVQITVVGSGTIGLSFAAFYTVSHRYYTITIYNTRRKPDSYTNSKLLALLPLDHPTPAIRYASTLQEAVQNASIIQECGPENLLFKQSLWSEIERFAPQDALLWSSTSGIPASLQSQRMQDKSRLLVVHPYNPPHIMPLLELVPSAETCEDVIQRTKQFWVENGRVPVHIKREITGFVANRLAFALLREAIHLVHQGIVSVEEVDNIVEMSMGPRWAVAGPFKSYHAGGGEGGLEGFFRNIGGTVQACWEDGGRISVGGEWEKIVFEQAKEIYGVIDIEERDRITSKVLEAVRGECTSQSSCYDCGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAX3</accession>
    <name>M2TAX3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_159600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD66032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699022.1">
        <property type="nucleotide sequence ID" value="XM_007700832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAX3"/>
    <dbReference type="GeneID" id="19131975"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159600"/>
    <dbReference type="HOGENOM" id="CLU_2209813_0_0_1"/>
    <dbReference type="OMA" id="LDYLEPH"/>
    <dbReference type="OrthoDB" id="3739674at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="107" mass="12483" checksum="4C7226ED3A31077D" modified="2013-05-01" version="1">MALTFSVDEKLRVPREIWLLVLDYLEPHDLRECRLVSRDLDPIAASLFFKTFVFQFSRHSVENLTQIASNERLAGYVRTLMLWRGPKRHDAVSRLDRDCKSFEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBC3</accession>
    <name>M2TBC3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_34744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697492.1">
        <property type="nucleotide sequence ID" value="XM_007699302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TBC3"/>
    <dbReference type="STRING" id="665912.M2TBC3"/>
    <dbReference type="GeneID" id="19137842"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34744"/>
    <dbReference type="eggNOG" id="KOG2969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057411_1_1_1"/>
    <dbReference type="OMA" id="SELFMAQ"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="156"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD66167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="255" mass="28545" checksum="CD9E8D0252EC7CAF" modified="2013-05-01" version="1">MAPTRMATSLFRTCRAASIRPTATWRQRCLYHSYDYPSSPPFPPAETAILSSAYAHVPNHGFTMDALKLGARDAGYLNVSTNLLPRGVFELINYHLVTQRLALQSNVQFPEESEHGKKMGAGAKVRTLTLARLRANAPIIHRWQEALAIMSQPTYVPASITELAKLADEIWFLSGDQSVDSSWYTKRATLSAIYSTTELYMTQDKSHNFVETEQFLDNRLQDLMKVGGFIGSLGEWLNYTGHSTINVLRSKGARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBH9</accession>
    <name>M2TBH9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_35048</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697565.1">
        <property type="nucleotide sequence ID" value="XM_007699375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TBH9"/>
    <dbReference type="STRING" id="665912.M2TBH9"/>
    <dbReference type="GeneID" id="19138027"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35048"/>
    <dbReference type="eggNOG" id="KOG1220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_1_1"/>
    <dbReference type="OMA" id="GYCVDPE"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="45"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="226"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="327"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="12">
        <location>
            <begin position="526"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD66541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="583" mass="64425" checksum="873E8EE051A42801" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCI2</accession>
    <name>M2TCI2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_84613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697988.1">
        <property type="nucleotide sequence ID" value="XM_007699798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCI2"/>
    <dbReference type="STRING" id="665912.M2TCI2"/>
    <dbReference type="GeneID" id="19141018"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_84613"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_10_0_1"/>
    <dbReference type="OMA" id="NEQWDIA"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000020">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="662"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="854" mass="96205" checksum="6A4249CBE781730F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2TD05</accession>
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        <recommendedName>
            <fullName evidence="1">PLL-like beta propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_33989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696514.1">
        <property type="nucleotide sequence ID" value="XM_007698324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TD05"/>
    <dbReference type="GeneID" id="19137396"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33989"/>
    <dbReference type="eggNOG" id="ENOG502S0DV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059884_2_0_1"/>
    <dbReference type="OMA" id="NQMYHKW"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22954">
        <property type="entry name" value="PLL_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058502">
        <property type="entry name" value="PLL-like_beta-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26607">
        <property type="entry name" value="DUF8189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLL-like beta propeller" evidence="1">
        <location>
            <begin position="12"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="347" mass="38988" checksum="83B197C0108A029E" modified="2013-05-01" version="1">MGSMPIPMRSWISIESWGPDRLDLVGIGTDNQMYRKQFDRGQDGWKPSLGGAWEPLEGKFMQIPGTISWSHGRLDIFGIGLDKHLYRKTWGNHRKTGGNWINNQWQRTDGELKSQPVPVSWGNGRIDIFAIGMDDQMYRKVYGGKWESDGWEPLTGKFKSPPAAVSWGSDRLDVFGIGMDNQMYHRAFENNAWTTPGWTGMTGAFKSPPAVVSRAPGRLDVFGIGMDDQMYHKAFDKGKWLTSNWQGIGGKFKSTPSVVSCDQGRLDVFGIGLDDQMYNKSFNDDKWLGDWKGMTGKFKSAPAAVSWGKGRIDVFGIGLDDAVWQQYYTDGKWSGKFVSLGGKFKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M2TE16</accession>
    <name>M2TE16_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_168671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Tu Z.J."/>
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                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD67651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEJ8"/>
    <dbReference type="STRING" id="665912.M2TEJ8"/>
    <dbReference type="GeneID" id="19132600"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_168831"/>
    <dbReference type="eggNOG" id="KOG0131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_21_1_1"/>
    <dbReference type="OMA" id="AMVYEIM"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000895">
        <property type="entry name" value="Hsh49p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000505">
        <property type="entry name" value="Splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD67651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="331" mass="34843" checksum="1DF227226078C9E8" modified="2013-05-01" version="1">MSAPSARHWEQNKEATVYVGNLHERVTPRILHELMLNTGRVRNVNMPVDRVNGQHQSFGFVEFHTEAEADYASKILNNVALYGSRIRVNKASADKQKNVEIGAELFVGNLDPGVDEKTLYDTFSRFGPLVNAPKVARDEVTTASKGYGFISYGDFESSDAAIASMHNQYIMSKQITVQYAYKKDGKGERHGDEAERMLAKQAKAHGVAPAVQPLPAHLFQLPPGAAPTGPAMPVDGRGVPGAPSGPGGYGPPSGPPGFVPNGPAGYGRPPSAAPIGHPSLPPPPTGLPARPPSGAPTNFFPPPPGFAAPPPGFGAPPPGFGGPPGYSQAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFF5</accession>
    <name>M2TFF5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_289597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697123.1">
        <property type="nucleotide sequence ID" value="XM_007698933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFF5"/>
    <dbReference type="GeneID" id="19135956"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_289597"/>
    <dbReference type="HOGENOM" id="CLU_135729_0_0_1"/>
    <dbReference type="OrthoDB" id="10577180at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="167" mass="18279" checksum="562C01F3F8E3A94B" modified="2013-05-01" version="1">MRLSSRPSASPSSSPPSSWTHKAGTGPESYGRRCVRVLLPLPLLLGSCSCCTPPPHIADVCAMPPPLRNFNLAGSTSYARLLRLMRLHPSIHPSIYGRFISDILTSVTWRSHHALNCLVPRSSLLCRLQSVLPETTFTGGIACRATPTRRKYTQQPSSLTICFVVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFW3</accession>
    <name>M2TFW3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">COCSADRAFT_136765</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD67617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFW3"/>
    <dbReference type="STRING" id="665912.M2TFW3"/>
    <dbReference type="GeneID" id="19131026"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_136765"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009454_0_0_1"/>
    <dbReference type="OMA" id="VRTNSHY"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000020">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF6">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="21">
        <location>
            <begin position="16"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMD67617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1102" mass="121510" checksum="40F9EBD4B4B6BADD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGG9</accession>
    <name>M2TGG9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_293614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699186.1"/>
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    <dbReference type="HOGENOM" id="CLU_1651995_0_0_1"/>
    <dbReference type="OMA" id="CCCKARV"/>
    <dbReference type="OrthoDB" id="3691408at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025960" description="SWIM-type domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17586" checksum="F7184E964D52ECEF" modified="2013-05-01" version="1">MTLVLPFLASPAPCCCCCKARVNGPCKHVYLAVNASCSTPAPLPSTHTHPTIRPSSWPHHDAPKSVRLKRQLHNLSWPDSPLVRQPACSFSAFGINIHPIGCHHVTTTAPPRCCRPLDTDSLPAEEIPSPTASTILTLESLEPCISFLRVMLLMTTTPHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGW4</accession>
    <name>M2TGW4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_134240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ND90Pr / ATCC 201652</strain>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2 4">Autophagy-related protein 13</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">COCSADRAFT_268102</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
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    <dbReference type="eggNOG" id="KOG4573">
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="6">
        <location>
            <begin position="79"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="68"/>
        </location>
    </feature>
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        <location>
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            <end position="486"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="580"/>
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            <end position="920"/>
        </location>
    </feature>
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            <end position="30"/>
        </location>
    </feature>
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        </location>
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            <end position="473"/>
        </location>
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        <location>
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            <end position="721"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="844"/>
            <end position="862"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="920" mass="99683" checksum="0673629413990CD5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIY7</accession>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694574.1">
        <property type="nucleotide sequence ID" value="XM_007696384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIY7"/>
    <dbReference type="STRING" id="665912.M2TIY7"/>
    <dbReference type="GeneID" id="19129968"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_105370"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003051_1_2_1"/>
    <dbReference type="OMA" id="FIGAHPF"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="PHI-base" id="PHI:4778"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000214">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="684"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="713"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD69171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="959" mass="104798" checksum="3F11577FAA0216AE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ16</accession>
    <name>M2TJ16_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_21445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694057.1">
        <property type="nucleotide sequence ID" value="XM_007695867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ16"/>
    <dbReference type="STRING" id="665912.M2TJ16"/>
    <dbReference type="GeneID" id="19134467"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_21445"/>
    <dbReference type="eggNOG" id="KOG3003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_0_0_1"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000011">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="229" mass="25923" checksum="8AC08D3B470BF723" modified="2013-05-01" version="1">MLQRTILRASRQQAARQLRAFAPLRQQSPITRAVATPAIRWYSDAPPAKEGEAAEKKEDAPAEKNEVSQLKEQLEKKDKEIVELKDKYLRSVADFRNLQERTKREIQGAKDFAIQRFARDLVESVDNLDRALGTVPEEKLKSDNTDLIALHDGIKMTDSILINTLKKHGLERFDPSESAEKFDPNVHEAVFQAPQPDKEDGTCFHTQQKGFKLNGRVLRPAKVGVVKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ32</accession>
    <name>M2TJ32_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_31963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694164.1">
        <property type="nucleotide sequence ID" value="XM_007695974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ32"/>
    <dbReference type="STRING" id="665912.M2TJ32"/>
    <dbReference type="GeneID" id="19136595"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31963"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017549_2_0_1"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="109"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="582" mass="64843" checksum="D3A2C68F1A54001E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJD9</accession>
    <name>M2TJD9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_32054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694187.1">
        <property type="nucleotide sequence ID" value="XM_007695997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJD9"/>
    <dbReference type="STRING" id="665912.M2TJD9"/>
    <dbReference type="GeneID" id="19136622"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32054"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="MVNQIFL"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="338" mass="37508" checksum="DEDFC36A7C4E7ADA" modified="2013-05-01" version="1">MNPALSKFMLKSTPKSILDPQPEMNTPIPLNTGATIPALGLGTWQSGPGEVKKAVVHAIESGYRHIDCAFCYQNEDEVGDALQDVISRGIVKREDLFITSKLWCTFHSRVEEGLQKSLDLLKTPYVDLFLVHWPVPMNPNGSHPLFPMLEDGSRDIDRSMTHQDTWKNMEKLIQTHPEKVKAIGVANYSVRYLEKLLAKATIVPAVNQIENHPLCPQQEVYDFCKEKGIHVSAYSPLGSTGSPLFGDEVINEVAKKHSVGPAVILLSYHLARNSSVLAKSVTPSRIDENKNLISLDSDDMAKLEKIHKDKGIQRYIYPPFGIDLGFPDKSDGVDLSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJF2</accession>
    <name>M2TJF2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_32068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694191.1">
        <property type="nucleotide sequence ID" value="XM_007696001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJF2"/>
    <dbReference type="STRING" id="665912.M2TJF2"/>
    <dbReference type="GeneID" id="19136631"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32068"/>
    <dbReference type="eggNOG" id="KOG1411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OMA" id="VGACTIV"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000181">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="53"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="425" mass="46434" checksum="C58D518DC0DDB6DE" modified="2013-05-01" version="1">MLASSRTALRQAATKQLSLKSSVRAVSAWSQVPQGPPAILGITEAFKADSNPKKINLGVGAYRDDKGKPYVLPSVREAEKKVVDSALDKEYAGITGVPNFTKAALKLAYGTDSKPLNEDCIAVTQSISGTGALRIGGAFLERHYPGPKTIYIPTPSWANHNAVFKDSGLKVEKYRYYNKDTIGLDFEGMIADIKAMPKNSIVLLHACAHNPTGVDPTEEQWTKIADAVKEGDHFPFFDMAYQGFASGDTSKDAFALRHFIKEGLRPVLAQSFAKNMGLYGERVGAFSVVCESAEEKKRIDSQIKIIVRPLYSNPPVHGARIASEILNDASLNKQWLGEVKGMADRIITMRALLKENLEKLGSKHDWSHITSQIGMFAYTGLTPEQMDKLAKEHSVYATKDGRISVAGITSENVGRLAEAIYKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKG0</accession>
    <name>M2TKG0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_212353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694917.1">
        <property type="nucleotide sequence ID" value="XM_007696727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKG0"/>
    <dbReference type="GeneID" id="19134422"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_212353"/>
    <dbReference type="HOGENOM" id="CLU_1283158_0_0_1"/>
    <dbReference type="OrthoDB" id="3692550at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="215" mass="24014" checksum="49B549DF287940E6" modified="2013-05-01" version="1">MCKETFSRHRHCTHSRLLNRTYCSLVVPPSFRTPSAARACPRYKQHREKPSAQIPCFACKRQERIREILAEEQEMARSELRAAGFSEGNVRVMMMPPPTGFVMPRLFPKRRVGGRDGGDVTGMMGHPLSRCAQDVHPLFRHAQEVDGSVTDDTRGLTPEKVDSRSSGDSSDSGLHKDIGEVKTKTGKGFKNWIKEFLLAGNVDEAVSIGFPKMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKX2</accession>
    <name>M2TKX2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_32072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694192.1">
        <property type="nucleotide sequence ID" value="XM_007696002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKX2"/>
    <dbReference type="STRING" id="665912.M2TKX2"/>
    <dbReference type="GeneID" id="19136634"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32072"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OMA" id="WWGEKIF"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="439" mass="49441" checksum="DB37D317ACCED9E6" modified="2013-05-01" version="1">MASSKPSYLVVGAGVFGISTAYHLIKKYPDRQITVVDQDAWDADNRVAASWDWNKVVRADYDDLIYCRLALEAQDVFKEDPLWKPYFHETGIFWVCRSDYAQEVIDNYKKLGRQADLQSVSVEEAKKMFGGLFEEANYDGAKSVLVNKTSGWAQAGDALRAVTKWSIEQGVKYVTQKVESLEFDNTGRCIGVRTEQGNTLSATHVVLSTGAYTAKLLEQAAKRSGNENLRAGSRIVAGGITTGMTTLDEKSYERFKHMPVGVQGYTAAYGPFIGSLPPTKDRELKWWGEKIFKNTHEVLPGRFVSAPPSGKDYNQWDVPGPLKLDIAHANDVFYGKKGANWKMDKHRICWDAFTTSSDFIISPHAGAKGLYVATCGSFHGYKFFPVLGKYVVQMLEDDLEPELKEKWAWDRERPAPSLNPDWPRFEMTDLLDQWPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKX7</accession>
    <name>M2TKX7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_106785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695023.1">
        <property type="nucleotide sequence ID" value="XM_007696833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKX7"/>
    <dbReference type="GeneID" id="19130008"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_106785"/>
    <dbReference type="eggNOG" id="ENOG502RXX5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005807_1_0_1"/>
    <dbReference type="OMA" id="DLPMTQV"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048537">
        <property type="entry name" value="RRN6_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20640">
        <property type="entry name" value="Rrn6_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="110"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 helical bundle" evidence="4">
        <location>
            <begin position="550"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
        <location>
            <begin position="849"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="814"/>
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            <end position="908"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20639"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20640"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69961.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_32607"/>
    <dbReference type="eggNOG" id="ENOG502RI70">
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    </evidence>
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        <source>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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    <sequence length="383" mass="43901" checksum="1200C19896CD90DB" modified="2013-05-01" version="1">MPFRDEDWEEWQRDCDIFPAYSDYLLGPDLRLVVAQEPGLHPLIYPTPILQPIQDTRNVRSRSQICRPMTRSGLATDTLTRRQSALHRGAFDDCLGNDSSNQTRALIDQPSFLRHPRTLSEIHEQSRQQLHTLIQTQSHSAAVLEQSCIPFSSEQASRVDMLQPNDIVHDPRYQCIQPETRNQIRRYLSGLWHIAKNSTDTGKKAKALADIHNFSTRVLERVKSTKANKGQHSPPHTPARNKPEQNDQRLRPTSTQLLHQQSVQSQAQVVEDNHPSQLEPQLAWQPPALPHTEIVAPQASAQLRVSINRYVPQVWYCLRITGNKFEPISADDLHRRNRAQQWLTSFKMTLPVEGRTYISGVLRWMYSEQAAGRDPLVSIGYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2TM03</accession>
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            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_177807</name>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="DUF7025"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
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        <property type="entry name" value="P450"/>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
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        <ligandPart>
            <name>Fe</name>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD70232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="504" mass="58048" checksum="9756653FAB7BEA62" modified="2013-05-01" version="1">MASGSDHETSGFWQPLVPLTSLHPIVAGVLLITVPIFAYAFYNAFLHPLRGYPGPLLWRCFRFPYVVSTQRGQIHRRYNEFHAKYGPIVRIAPNELSYADGRAFRDIYVNRAGHQPFEKTRKFFKKMSPEDATTIMDWHEDNHARYRRAFANAFSEKSLKSQAPVIEQHVDGFMAQLKKRNTVNLTDWFNFLTFDLAGDLSYGESFGCVDNGKAHPWVEIAQDFGKGLSMIAAVNLYPPVDKILRYIIPKRILQRSIDHRLMSYAQAKKRIARDVERPDWVTPTKKYTDQKDQFTDREWGMNLLVIAFAGSETTASALTAITRMLVQHRGVLHRLTREIREKFQNESDITVATTSDLPFLNAVINEGMRLGPPVVIGLPRVVPEGGDLVCDRWVPGGTYVVFNQFSAFRQSYNFSNPNSFIPERFLTPNKNDDMTVFQPFQMGRHMCIGMKVAYQELRLTLSRLLWSFDLVLKDPKDVWDWGQQSTYILWEKKPLEVVLSHVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2QT72</accession>
    <name>M2QT72_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_165582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705840.1">
        <property type="nucleotide sequence ID" value="XM_007707650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QT72"/>
    <dbReference type="STRING" id="665912.M2QT72"/>
    <dbReference type="GeneID" id="19132393"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_165582"/>
    <dbReference type="eggNOG" id="KOG3482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_12_1_1"/>
    <dbReference type="OMA" id="GYMNVQL"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD58374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="93" mass="10238" checksum="B10BE7CACC321E59" modified="2013-05-01" version="1">MAAVAPFNPRPLLQSLVDKDIVVRLKWGETEYKGRLVSVDLYMNIQLSNTEEFVNGVSSGTLGQVLIRCNNVLWIGKAEEVEPKTGKDTAMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2QVX8</accession>
    <name>M2QVX8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_347787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705011.1">
        <property type="nucleotide sequence ID" value="XM_007706821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QVX8"/>
    <dbReference type="STRING" id="665912.M2QVX8"/>
    <dbReference type="GeneID" id="19137858"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_347787"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_2_1"/>
    <dbReference type="OMA" id="HRYRQGG"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="417"/>
        </location>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="445" mass="51300" checksum="0804C05FEC440ABE" modified="2013-05-01" version="1">MHSLIKHLKSDKADEEPHQPQSDAPVKRSRAPAKPPSNDPNIPKKRLHLNQICLYERRLPGRAYVSAHVNRLQHGFYRSDVLHGAAINHVYFVSVRFVFHPHDPESHRFRSAEIQVSLHGEDPSSGSHRRSGRSQPRILKHAPELMFGAVSPENLQWNFSLSTSLGVSPASPVGAYIIPQASVQSSYKVFHMMSIQGSVRSRQDRSGQTIEDSKAVWTLSENVLQKSGLPREFDFVMLVQKPKDVKNIYMTVNVDTSVATWYGAYPQWYNNLSEYVPSQNFAVSFEHDVGQRFLPSHPGLGYNFADLIHSLDQYVMMPGTIYPTAGTNQGEFNPNQTHRRPLEENKVNEPDRPPSRSKRRPRSPSEYQSRIQDSSQRERRNWTPEHIDVRLVVDHRFPRSPNPRRFSYSPPHVVETRRHPSIRRRKSQIRLKECGEAEFRRTYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="135"/>
            <end position="167"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="167" mass="18616" checksum="AA9E66F5303B1399" modified="2013-05-01" version="1">MNRIHPTTCIQSFEAQKASRTKIPNGIHVMDLLTAMHPSPQGVSPRLAEWNCIYIPLAHRLTHSRLQSHVSFNDILLELRCAQGHKLCDFGNTKSTAWHEDDMSSMHSSISSARIGEHGNSKICNAVTCRRTYQPVHSGKNSSPGSLEHPSRFRRKPCSPPSVLQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZI8</accession>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60484.1"/>
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            <begin position="27"/>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60484.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="124" mass="13636" checksum="5EE7CBA924F041FB" modified="2013-05-01" version="1">MSALPSTLVGLPPILLSSFLKGHVSVVYTHFVMCDLLPLFTLHYLSCFWHLASIRRSANVKDVRLEFIASSESIYGSSNRCFVVSMPLDSSFAAMLAAAAAMRLVRDLSQSLKVWPRDATAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_191647</name>
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    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701774.1">
        <property type="nucleotide sequence ID" value="XM_007703584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R5E4"/>
    <dbReference type="GeneID" id="19133776"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_191647"/>
    <dbReference type="eggNOG" id="ENOG502SSJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560205_0_0_1"/>
    <dbReference type="OMA" id="HLRICRG"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
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    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
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    <dbReference type="Pfam" id="PF01544">
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    </dbReference>
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        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD62389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="487" mass="53979" checksum="EFF78959C937F514" modified="2013-05-01" version="1">MVDVAPTASSNNTSNGIQNSRGPIPVLPTEIFDLDSLLTCLRDILNGRIFQASAVKQLLSSLLETNSEPVAGTIEQKLKEETNGYYVIADIDTLGNTFFQPPTKAAEGLWALLKGGSSGYLPDPGWKGPRNIWFFSLKYYYISFEDQDVYPGQQSGPFHKNLPHLRICRGSSSVALSFSDTEGANTSAALPWRLLILSCNRDHASSRKIKNGVEAFCWGINSELRKVRRCLREVAAQISSVSAPSDDFLFNNEVRESLLFENKDFTNSRTYFWALQSLRLVNECIASIIRIWDIYDKASFLNLLNTGDDGISHTPPSSDGEAAATRTASIPYLNEIQKQMTQLACMIKDNSAKQEEIRALRDGLFNASSVLETRTTVAQGKNIHVLTLISMVFLPASFATSIFGMQSILPTSTSLTTFAIVMICVCGPAYLIILVLSRGLKGAGDVWKKTAKFWDGRCKVDGKKWFDGTKTMMRKKRNKQKDTEKGI</sequence>
</entry>
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    <accession>M2R7B0</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
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    <organism evidence="1 2">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R7B0"/>
    <dbReference type="GeneID" id="19141452"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92468"/>
    <dbReference type="HOGENOM" id="CLU_209445_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="50" mass="5824" checksum="D901B88655575957" modified="2013-05-01" version="1" fragment="single">LLPIAQIVYNNKTLELISKILFFANYGQHLNFFTRIYLSLKIEVVIVIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M2RAG8</accession>
    <name>M2RAG8_COCSN</name>
    <protein>
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            <fullName evidence="11">Polyketide synthase PKS17</fullName>
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    </protein>
    <gene>
        <name evidence="11" type="primary">PKS17</name>
        <name evidence="11" type="ORF">COCSADRAFT_91588</name>
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    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700864.1">
        <property type="nucleotide sequence ID" value="XM_007702674.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2RAG8"/>
    <dbReference type="GeneID" id="19141408"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_91588"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_2_1"/>
    <dbReference type="OMA" id="FRINTMI"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="478"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1388"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1754"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1388"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1550"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1835"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1835"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD63879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2275" mass="247862" checksum="E29E644719337168" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBC7</accession>
    <name>M2RBC7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_199548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700010.1">
        <property type="nucleotide sequence ID" value="XM_007701820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBC7"/>
    <dbReference type="STRING" id="665912.M2RBC7"/>
    <dbReference type="GeneID" id="19134101"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_199548"/>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000048">
        <property type="entry name" value="Proteasome subunit alpha type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD64134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="279" mass="30069" checksum="73E49CAE7848D70D" modified="2013-05-01" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTSLGIKATNGIVLATEKKSSSPLIDSQSSSKISLITPNLGMVYSGMGPDYRVLVDKARKVSHTGYKRVYNEYPPTRILVQDVARVMQEATQSGGVRPYGVSLLIAGWDDGIEPEAEGKSDEQTSEEKKKVSGKTGGILKGGPSLYQVDPSGSYFPWKATAIGKSATSAKTFLEKRYTDGLELEDAIHIALLTLKETIEGEMNGETVEIGIVGPPEERLLGVEGVEGAVGPRFRKLSPSEVEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBK3</accession>
    <name>M2RBK3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_357137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700077.1">
        <property type="nucleotide sequence ID" value="XM_007701887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBK3"/>
    <dbReference type="GeneID" id="19138478"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357137"/>
    <dbReference type="HOGENOM" id="CLU_013929_9_0_1"/>
    <dbReference type="OrthoDB" id="3937230at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="178" mass="20856" checksum="B61B0D38A4689A8B" modified="2013-05-01" version="1">MAQSRYMLTQAIPFDAPTAWTSPLQDDAIPYHTRYYRRRRRPSMQEKAQGQQYLTPDEEKALVAYLLLMSELGQPVRIKYIPLLAFSLARRRTTTTTGKPIKPPGKNWARFFEKRNPRLKGRKVKAIDWKRHEQNIYTKVTHWFEVIRGVLQDPRVRPENVTGRSSVLRCLHAAQHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBV5</accession>
    <name>M2RBV5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_36904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699818.1">
        <property type="nucleotide sequence ID" value="XM_007701628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBV5"/>
    <dbReference type="STRING" id="665912.M2RBV5"/>
    <dbReference type="GeneID" id="19138846"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36904"/>
    <dbReference type="eggNOG" id="KOG0155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013872_1_0_1"/>
    <dbReference type="OMA" id="MLKSTYT"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000049">
        <property type="entry name" value="Transcription elongation regulator 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="371"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD64329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="66651" checksum="5F7565A93AB7FA2E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2RD45</accession>
    <name>M2RD45_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_140845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699318.1">
        <property type="nucleotide sequence ID" value="XM_007701128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RD45"/>
    <dbReference type="STRING" id="665912.M2RD45"/>
    <dbReference type="GeneID" id="19131181"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_140845"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026724_0_0_1"/>
    <dbReference type="OMA" id="DTIFVAM"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD64729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="530" mass="58576" checksum="E57F0A835F718312" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RDD7</accession>
    <name>M2RDD7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_115938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699396.1">
        <property type="nucleotide sequence ID" value="XM_007701206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RDD7"/>
    <dbReference type="STRING" id="665912.M2RDD7"/>
    <dbReference type="GeneID" id="19130305"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_115938"/>
    <dbReference type="eggNOG" id="ENOG502QQD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_7_0_1"/>
    <dbReference type="OMA" id="GLGFDWN"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD64839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="63407" checksum="DDB5FE3C8B8CB9F4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRB0</accession>
    <name>M2RRB0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_31857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694130.1">
        <property type="nucleotide sequence ID" value="XM_007695940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RRB0"/>
    <dbReference type="GeneID" id="19136555"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31857"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543078_0_0_1"/>
    <dbReference type="OMA" id="DQCIEAY"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="45"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="539" mass="61236" checksum="F8F1E66E406200CF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRS2</accession>
    <name>M2RRS2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">AAR</name>
        <name evidence="20" type="ORF">COCSADRAFT_105593</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694654.1">
        <property type="nucleotide sequence ID" value="XM_007696464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RRS2"/>
    <dbReference type="SMR" id="M2RRS2"/>
    <dbReference type="STRING" id="665912.M2RRS2"/>
    <dbReference type="GeneID" id="19129974"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_105593"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_19_1_1"/>
    <dbReference type="OMA" id="ENDKFTM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
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        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="638"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD69274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1181" mass="130848" checksum="1CCF6A71EA60D0B5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT78</accession>
    <name>M2RT78_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_104018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705874.1">
        <property type="nucleotide sequence ID" value="XM_007707684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT78"/>
    <dbReference type="GeneID" id="19129886"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104018"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_3_1"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="172"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD58418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="403" mass="45203" checksum="8089CFF1A7182EE1" modified="2013-05-01" version="1">MLTLLGQLRTLTTRIEAYLSQTSKTPASTEDREFDTLRNEYLETINNTALHLTHPLEYWSSIRGACADTAVFRCANEFELFQRIPLTGTATSTSLAAAVGVDTGVLTRVLRLLSARGCFQEVSECTFAHTPFSAFVQEHPHFASFLRATFEVFGGSAATLPDSLLAPVGENGARPSAFEVRFGEGCYEFWAKQPEKLARFQRGLHEPLLLHEINESYNWDDVKGTIVDIGGGEGQVARCLAEHFEHLKFLVQDTFVKEDVIAGIARGGLADRLRFEVHDYFTPQKSLDQGAFFLKHCLHNNDDENCVRILKAIAPAMESSGPETRLIIAENVLPEWNDTSLSRQQRVELFQDDISMLQLFNAKKRSAAEYQELLHQADPRLRIFGIHRPPRGQLCCIDVRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RY47</accession>
    <name>M2RY47_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_100248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704249.1">
        <property type="nucleotide sequence ID" value="XM_007706059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RY47"/>
    <dbReference type="STRING" id="665912.M2RY47"/>
    <dbReference type="GeneID" id="19129685"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_100248"/>
    <dbReference type="eggNOG" id="KOG4623">
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    </dbReference>
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        <property type="term" value="C:chromosome, centromeric core domain"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ima1 N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
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            <end position="421"/>
        </location>
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        </location>
    </feature>
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            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD59988.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="581" mass="65773" checksum="F98FA87244684EAB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2RY79</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_346476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="558"/>
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        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="934" mass="105638" checksum="96CF8A0A49EFCDBE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2RYQ0</accession>
    <name>M2RYQ0_COCSN</name>
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        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_40586</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007705937.1"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_40586"/>
    <dbReference type="eggNOG" id="KOG4492">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate_synth"/>
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    </dbReference>
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        <property type="entry name" value="Chorismate synthase, AroC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
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    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD60153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="415" mass="44452" checksum="0DA7D604B6FDC304" modified="2013-05-01" version="1">MSTFGTHFRVTTYGESHCLSVGAIIDGCPPGMALTEADMQPQMTRRRPGQSAITTPRNEKDRVEIQSGTEFGITLGTPIGIRVMNENQRKQDYGNQTMDKYPRPSHADWTYLEKYGVKASSGGGRSSARETIGRVAAGAIAEKYLREAYGIEIVAFTNSIGNEFLFPPTPEHPTASTNPEFLKLVDTITREKVDEYLPVRCPSDEVTRRMEDLIAKYRDAQDSIGGTVACVIRNCPTGLGEPCFDKLEAKLGHAMLSIPATKGFEIGSGFGGAQVPGSIHNDPFIKAPAVPAGENPSAKVFRSKPKLTTKTNNSGGIQGGISNGAPIYFNVAFKPAATIGQAQSTVTYDQEDGVLEAKGRHDPCVVPRAVPIVESMAALVIMDAVLAQQARQGARGLLPAIKGVLPVQMQGGGEE</sequence>
</entry>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_144764</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701181.1">
        <property type="nucleotide sequence ID" value="XM_007702991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S6T7"/>
    <dbReference type="STRING" id="665912.M2S6T7"/>
    <dbReference type="GeneID" id="19131326"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_144764"/>
    <dbReference type="eggNOG" id="ENOG502T17B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068279_2_2_1"/>
    <dbReference type="OMA" id="WERVAIS"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="278" mass="32317" checksum="106A9CB3E9669CC5" modified="2013-05-01" version="1">MATPCTPEATEPNPPKKALFFGTSAKQGFVVVKAGSEKVQYDVHKTLLTYHSKYFSSALNGSWKEAEENSITLNDIDPKTFGVFVHWLYTQKIATEEEVDHMLETYPSDEHDDDPYITVLTKAVVFGNRFLVPDFCKAAQNHIVDSIFDRDEIRNPTFLYASKYAFENLLDEHLICTFFIDAHCRYMVCKGSYMDRITTGWFKENLPRTFLVGLIEKYSVLLAKRSGLGGLDYINCCMYHAHTDDRDRDKCKRKRRFADCVRRIWDSEREKFVDKYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6T9</accession>
    <name>M2S6T9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_42123</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445753">
        <property type="protein sequence ID" value="EMD58080.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="10253869at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12521" checksum="9A612E3507D66DA7" modified="2013-05-01" version="1">MVQAVEMLSSWHGPDWSELKVGKESNGSLNAVPIGPPPTILIRATENSFLESQQSHLGWDEYKQDFFKRIIRVPGNHFTMFTDDHVAYVADALHEACQLLERLTAVVPSNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2S740</accession>
    <name>M2S740_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_104522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445671">
        <property type="protein sequence ID" value="EMD58185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706113.1">
        <property type="nucleotide sequence ID" value="XM_007707923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S740"/>
    <dbReference type="GeneID" id="19129916"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104522"/>
    <dbReference type="eggNOG" id="ENOG502S62N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_15_4_1"/>
    <dbReference type="OrthoDB" id="3776271at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10456" checksum="FD68C5CA19AD02A8" modified="2013-05-01" version="1">MRDRIASLERANIAVSERRKRKKKRIQKRGVLTKGAGEDLLAQREADQQIAHEERQGGERLGVSRQALARCSRCRETGHNARTCKKDTLDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7V8</accession>
    <name>M2S7V8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UMP1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_103982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705943.1">
        <property type="nucleotide sequence ID" value="XM_007707753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7V8"/>
    <dbReference type="GeneID" id="19129879"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103982"/>
    <dbReference type="eggNOG" id="KOG3061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_1_0_1"/>
    <dbReference type="OMA" id="SGVHRDI"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="58564" checksum="ED874FCD8DD2372B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8D9</accession>
    <name>M2S8D9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_176105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705337.1">
        <property type="nucleotide sequence ID" value="XM_007707147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8D9"/>
    <dbReference type="GeneID" id="19133010"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_176105"/>
    <dbReference type="eggNOG" id="KOG1773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685140_0_0_1"/>
    <dbReference type="OMA" id="NCEYKLW"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF116">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD58860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47002" checksum="5E8E66E732D8321C" modified="2013-05-01" version="1">MPFTASDICKILLAIILPPVGVFLERGCGADFLINILLTILGYIPIYLTATLTHAEINLISNPNRPSYDTIRDLEIASQSIRSNADQFEESLRIKNTLDAFARRAAVEPSLEALAAILNCEYKLWKMNEDIPVRFKPFLSHWIESLMVIDGELAALRLDTVTGIHMKNTVTTDEILRIRARCIKGLLVDKPLSPKEPTWRAYQRMLENEAALPDFDIVPYMQMLVETQIWDRLPEAQAQTVEKHAQNGTEKNGLRKGKTQGVNGSGSWEEDMLRKLRDAPEVAADELAHLPLEILSLDFLTRLLVDDTFKEFDVDGSNIILRFIQHALRLVEAMEAPPPTLELTTNGTPIVEYGKEAQTRAISILLLFIKNSMSKGKLDAGMLIFEIQEICIRYLWMKEVREFRAWIEQGPWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAP1</accession>
    <name>M2SAP1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_100601</name>
    </gene>
    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="279" mass="30225" checksum="02DEFBDDA69F6722" modified="2013-05-01" version="1">MIEAFKDMKHGKSSSYDSLALERTASQILHRIEDKDSEYALESIRTRVLANARAIYGPNRYLDVISFAPTSSRRVGACIVEHNPSSKSYIHCCSAKETSRLAALEHLLVITEDLLQRLMDFEGITSNGWLPATPQSQHAAMYGSACGSTVGGTGSGSMTSSVQTSRRGSAQPQDVFPDHAHGSPQSTQLPQQLQHPLPVPSQLPFVNDFNAPSSPHHIQKPRLPRGGSETSFPTSTPKPMAQTIARTNSDVIQHPKPVPVGQLAVPGRGRVQWNLGSEG</sequence>
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ND90Pr / ATCC 201652</strain>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
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        <property type="entry name" value="SAT4-like"/>
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    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="30"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="116"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="149"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="240"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="282"/>
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    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="compositionally biased region" description="Pro residues" evidence="6">
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD64878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="388" mass="43594" checksum="7DDEDA01A46B0382" modified="2013-05-01" version="1">MYLRPGFVVVIVGGVLTTISTIVVALRYYCRYFLVGSLSASDHLMLVSLVIAWGTFIINYYQDVTSSGYRPTYLRRPDKRPEIEGYVLGVLISWWAYRFVYVIGLGFIKLSILFFYRSIAANVTFRRIVYGTMGFVVLYTFSATIAAIFQCQNPASAWSTTNYFAQFDPTLQREPAVCWDPVPLWVFSSACNLLTDVIILLMPLPTLLSLRIPMGKRLALIGIFSVGLMAIVASSVRMWVMYMWAESPYNSARYGADLLLWGQVETNSGIISASVPFLRLLFRNKEKKPQQSGTPQKIFATPPEAQPPTPPKDDEYSPRKVPDVEMWPLPNEKGLDRGDSVGFITIHERSTIARESNWGPFVTIPESLSSDGKDSPYLAPPFSPHKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCR0</accession>
    <name>M2SCR0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Septum-promoting GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_116415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699567.1">
        <property type="nucleotide sequence ID" value="XM_007701377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCR0"/>
    <dbReference type="STRING" id="665912.M2SCR0"/>
    <dbReference type="GeneID" id="19130325"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116415"/>
    <dbReference type="eggNOG" id="KOG1673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_0_0_1"/>
    <dbReference type="OMA" id="PRHGYYD"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD65063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41230" checksum="68599C09F9556018" modified="2013-05-01" version="1">MEEYSSQAPVSETLPQPVQVPPEQLGHDQLQPEAVLVDEHEAQKHMDQTMDTNDDSMASTITANTVTPLPDPAQSNSLNNSPSPYGHEPHRPSTSYSDTAYQYTTHNGSRFTTSSDADTPPRHGYYDSSREAHVGQSHSRPSSQMGRYPTSEGGARSNSYQDQQRSAQQQQEAVKNASVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPFLVGTKYDHFVNFPREEQEEISNQAKRFARAMKASLIFSSTSHSINVQKIFKIVLSKAFDLKCTIPEIENIGEPLLLYQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCT0</accession>
    <name>M2SCT0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_163643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703677.1">
        <property type="nucleotide sequence ID" value="XM_007705487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCT0"/>
    <dbReference type="GeneID" id="19132262"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163643"/>
    <dbReference type="HOGENOM" id="CLU_628481_0_0_1"/>
    <dbReference type="OrthoDB" id="5237073at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025660" evidence="1">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="356" mass="40462" checksum="AF2B34FF2FFC2E19" modified="2013-05-01" version="1">MFFEHLTLILSCLLLQVHAFRFSPPSDDTAFGINFGKHVGREEDRLNRYLWAGVRDSPYVVHDQKAKVITYRLPLRKRAQDPLIGFPNCLKCAGGARFNGNLDVDRDLTASILKRAIKPGGQDGQCLFYGQREDMWPKDESRACDKQTETSGYDYYCLNAWEPKCCWLNGLWGEGGKEIMENNIPSRDARELKTRPYFQQMSQAMAETCTGDVYVVHEHYDELATYQPKGQNPSIWISHELPALRRSQLRGILGKVWVIPVVPALLSGVEGLAANTDRSTWQDQTKVLNSGAARRYVEDHEGMALEWKMIREALRLQERQRASSPPNNSTQALEARWQTCRNSAAAREAKGADYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SD29</accession>
    <name>M2SD29_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_242435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703761.1">
        <property type="nucleotide sequence ID" value="XM_007705571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SD29"/>
    <dbReference type="GeneID" id="19135038"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_242435"/>
    <dbReference type="HOGENOM" id="CLU_168406_0_0_1"/>
    <dbReference type="OMA" id="RANQHCA"/>
    <dbReference type="OrthoDB" id="3674363at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="86" mass="9714" checksum="0304209E5D9FC3F9" modified="2013-05-01" version="1">MSCPTHNHHHRLRTDNNNDAAANQSVRIRRHTPHEPVANRCPIHSPSADSVTRANQHCARPLSNNALVYGSVIRITATKRLRIFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDY1</accession>
    <name>M2SDY1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_306311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698628.1">
        <property type="nucleotide sequence ID" value="XM_007700438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SDY1"/>
    <dbReference type="GeneID" id="19136282"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_306311"/>
    <dbReference type="eggNOG" id="ENOG502SI37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013869_1_0_1"/>
    <dbReference type="OMA" id="TYFASYV"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="734" mass="81349" checksum="604405D0EB88E581" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SES3</accession>
    <name>M2SES3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_98214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703319.1">
        <property type="nucleotide sequence ID" value="XM_007705129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SES3"/>
    <dbReference type="STRING" id="665912.M2SES3"/>
    <dbReference type="GeneID" id="19141774"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_98214"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082854_10_1_1"/>
    <dbReference type="OMA" id="MKNMGGK"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD60960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="106" mass="12175" checksum="132364F67834788E" modified="2013-05-01" version="1">MPKEKTTRKAAPKTKAEKKKKVADPNAPKRGLSAYMFFANEQREKVREDNPGIKFGEVGKLLGEKWKALNEKQRQPYEAKAALDKKRYEQEKAAYTAADEEEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFZ9</accession>
    <name>M2SFZ9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_295570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697723.1">
        <property type="nucleotide sequence ID" value="XM_007699533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFZ9"/>
    <dbReference type="STRING" id="665912.M2SFZ9"/>
    <dbReference type="GeneID" id="19136067"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_295570"/>
    <dbReference type="eggNOG" id="KOG2965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_6_1_1"/>
    <dbReference type="OMA" id="YKEFRYA"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD66163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="324" mass="35086" checksum="A4292123049BBE19" modified="2013-05-01" version="1">MTSAPTKQPNFLPSRHELGIVAVGFSGGQPKAGVDAAPMALIENGLIKQLEEDLEYNVTYDGQVHNYSELQPTEDPDYRGMKRPKFASAVTREVSNQVYKHAKDGKLVLTLGGDHSIAIGTISGTAKAVRERLGREIAVIWVDAHADINTPETSDSGNIHGMPVSFLTGLATEDREDVFGWIKEEHRLSLKKLVYIGLRDIDRGEKKILREHGIKAFSMHDIDRHGIGKVMDMALGWIGNDTPIHLSFDVDALDPMWAPSTGTPVRGGLTLREGDFIAECVAETGSLIALDLVEVNPSLDAEGAGDTVRAGVSIVRCALGDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SG98</accession>
    <name>M2SG98_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_296613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697806.1">
        <property type="nucleotide sequence ID" value="XM_007699616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SG98"/>
    <dbReference type="STRING" id="665912.M2SG98"/>
    <dbReference type="GeneID" id="19136093"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_296613"/>
    <dbReference type="eggNOG" id="ENOG502QT5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_0_1_1"/>
    <dbReference type="OMA" id="RDKGTEC"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="965"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD66273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1123" mass="124755" checksum="5DCD0B101DA77D6D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGU1</accession>
    <name>M2SGU1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_39309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702621.1">
        <property type="nucleotide sequence ID" value="XM_007704431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SGU1"/>
    <dbReference type="STRING" id="665912.M2SGU1"/>
    <dbReference type="GeneID" id="19139469"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39309"/>
    <dbReference type="eggNOG" id="KOG2114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001287_0_0_1"/>
    <dbReference type="OMA" id="ENENECP"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000440">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002146">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001145">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="403"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="880"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD61610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="974" mass="108651" checksum="0B8110DF4A59E5E7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJA8</accession>
    <name>M2SJA8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_34114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696543.1">
        <property type="nucleotide sequence ID" value="XM_007698353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJA8"/>
    <dbReference type="GeneID" id="19137456"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34114"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_1_1"/>
    <dbReference type="OMA" id="TRTHAKY"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="125"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="672" mass="75154" checksum="AA2726CFF9A24DA4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLE3</accession>
    <name>M2SLE3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_337384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701336.1">
        <property type="nucleotide sequence ID" value="XM_007703146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLE3"/>
    <dbReference type="STRING" id="665912.M2SLE3"/>
    <dbReference type="GeneID" id="19137287"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_337384"/>
    <dbReference type="eggNOG" id="ENOG502QV88">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011273_0_0_1"/>
    <dbReference type="OMA" id="LNGWGIE"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF11">
        <property type="entry name" value="PROTEIN DSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="278"/>
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                <person name="Henrissat B."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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    <organism evidence="7 8">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="673"/>
            <end position="719"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD58567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="749" mass="82030" checksum="9B4010429AD7602D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPJ9</accession>
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        <recommendedName>
            <fullName evidence="10 11">Cytochrome b mRNA-processing protein 4</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CBP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699793.1">
        <property type="nucleotide sequence ID" value="XM_007701603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPJ9"/>
    <dbReference type="GeneID" id="19138821"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36809"/>
    <dbReference type="eggNOG" id="ENOG502S2G8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136894_0_0_1"/>
    <dbReference type="OMA" id="DKPIWVV"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD64235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="117" mass="13337" checksum="4A9E641383E41BE7" modified="2013-05-01" version="1">MPSARTYIKAFSAGAVLCVGGPALVWYVTPTEEEIFKRYNPELQKKALAGREQRQKEFDAFVGQLKEAARSDKPIWTAQKEMDAKRSEAEQKARRDERDAYAAESRRRQAEIRASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQA3</accession>
    <name>M2SQA3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_261767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705392.1">
        <property type="nucleotide sequence ID" value="XM_007707202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQA3"/>
    <dbReference type="GeneID" id="19135436"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_261767"/>
    <dbReference type="eggNOG" id="ENOG502RVJH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103869_0_0_1"/>
    <dbReference type="OMA" id="HDDMKRF"/>
    <dbReference type="OrthoDB" id="3796480at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="234" mass="26625" checksum="90CA85108D7DC6CF" modified="2013-05-01" version="1">MARLSLDDFDQHISSLRAQLLFLNETLEATDHNAPDWLATDLISLRNKSGRLHDDMKRFRDQLESEGLAEKKVKTSNKRLSLEGAKHATPTPNTHTYASSSHAISPLTGQSPTPRAKTAQAEGAHLVQHIDVTEEVNRRLQESRLRRLMQTPSTAQKRKYNEYDDAPSSGGPAATEEEDLKNQQSGGEYEKTPTKRLRSSGAFEHTRDRKDDGPVRYDTERFDDRTDVKRRKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQC7</accession>
    <name>M2SQC7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_26642</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699729.1">
        <property type="nucleotide sequence ID" value="XM_007701539.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SQC7"/>
    <dbReference type="GeneID" id="19135527"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_26642"/>
    <dbReference type="eggNOG" id="KOG3600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002210_0_0_1"/>
    <dbReference type="OMA" id="DRCTLFG"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="1085"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1278"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1610"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="120"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="448"/>
            <end position="499"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">ND90Pr / ATCC 201652</strain>
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    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">ND90Pr / ATCC 201652</strain>
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        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50969"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
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    <sequence length="600" mass="66733" checksum="3B51DA923104F5D0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRM5</accession>
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        <name evidence="3" type="ORF">COCSADRAFT_316232</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19136481"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_316232"/>
    <dbReference type="HOGENOM" id="CLU_1427758_0_0_1"/>
    <dbReference type="OMA" id="WAQESSY"/>
    <dbReference type="OrthoDB" id="3797249at2759"/>
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        <location>
            <begin position="1"/>
            <end position="17"/>
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    <feature type="chain" id="PRO_5004025292" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="18935" checksum="004B424EA3309329" modified="2013-05-01" version="1">MVRVILAVAGFVAVALAQQSTYTGPIFDEDTAPYFGSSGLVFPTSADGTPAFPSAPTITPSASSSTIPTPISSSVSGSVSSSMLSSMLSSVLSSIPSSIPSSTLSTAVSQNSTISSSSTTSSASTISSPATTLSSSSRSSTSVSVSRTSSSTTEDATTSRLTPSSTSTGAAATNFPEALGIMVGSLVAGMAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRV0</accession>
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    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_254533</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704781.1">
        <property type="nucleotide sequence ID" value="XM_007706591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRV0"/>
    <dbReference type="GeneID" id="19135289"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_254533"/>
    <dbReference type="HOGENOM" id="CLU_1354500_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="202" mass="21497" checksum="59E151D8B0D76ABC" modified="2013-05-01" version="1">MPEPMCSDPRVATHGLHTLCLAAAQAGCQATKISAGLGPTALLRDPWAGSCRSVVPETWQWQSARHADVARRSRGSMGCCSLVGSSVVVFGIRRFSVATSLPIQGNSSNLCSVCGATLLSSCLRLAQTRITRAADGCGHRKSGKLGRIALPGSVPIRRSEKLKREAKRKKDDPNALTSRDPNGEVAECSIAHFPSSEKLPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS12</accession>
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        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_132455</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS12"/>
    <dbReference type="STRING" id="665912.M2SS12"/>
    <dbReference type="GeneID" id="19130848"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_132455"/>
    <dbReference type="eggNOG" id="ENOG502S5WK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098391_1_0_1"/>
    <dbReference type="OMA" id="SRQEAQF"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD70018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="166" mass="18937" checksum="44CAEEF1F7E116DA" modified="2013-05-01" version="1">MILRPSTLRLSIPTPRPFSLFPSSRSPTNRIFDPIRQPNDLHTLTLLNAADNRALITFWTASWCQTCQAIKPLLRKLIEEEKVGEREGGLGFVEVMMDSVLIEDLPIRYRISSMPTLLAFSRQEAQFDTRLTRPEEMRNKEFLREWLVKEASRGGRRGGGGGSMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS75</accession>
    <name>M2SS75_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deubiquitination-protection protein dph1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_40841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704501.1">
        <property type="nucleotide sequence ID" value="XM_007706311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS75"/>
    <dbReference type="STRING" id="665912.M2SS75"/>
    <dbReference type="GeneID" id="19139848"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40841"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024293_0_1_1"/>
    <dbReference type="OMA" id="PGMDMFG"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="47741" checksum="A51F59D252251542" modified="2013-05-01" version="1">MADDAATSAEETQITFNVKAANDQKHVLTLPSTTTVADLKAKLSTSEYADVPADRQRLIYSGRVLKDPDTLASVKIKDGHTVHLVKGAASNARQNPASQGTASTAGTSTTPTPQVPTNIAAGTGNNPLAGLTGARYAGFHGLPGMDMFGPDGGMGPPPTTESMLEQMENPMFLSQLNEAMNNPAVVDMMLQSPMIRDNPMLQQVLRDPEMRRMMFSPEMMRMQLQMQRNMGGRAPGAPPSFPAPGATDNTPQSGSTATGEGATATPNQTNTTTPPNPFAAFGGGAGAGAGAGAGAGAGANPFASLFAGGQNPFAPQQQQGANTGAPQNTQDASSTFPNLFGGAGAQGGQTNPIAEAAQRMMQNPEAMRNMMQMMGGGAGADPFAAAGGAGQPPAGNPFAALFGPGGFGSPPPPADNRPPEEVYETQLRQLNEMGFYEFDRNVSALRRSGGNVQGAIEYLLNGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS94</accession>
    <name>M2SS94_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_40410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704075.1">
        <property type="nucleotide sequence ID" value="XM_007705885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS94"/>
    <dbReference type="STRING" id="665912.M2SS94"/>
    <dbReference type="GeneID" id="19139730"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40410"/>
    <dbReference type="eggNOG" id="KOG1262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025883_0_0_1"/>
    <dbReference type="OMA" id="TKWLYAH"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="505" mass="57555" checksum="0904F14D5FA45389" modified="2013-05-01" version="1">MERHKNTVEAVRSRVQHFYATEAAFRIYHGSTNSTRHADFDRDAVVDVSTLNHIISINHDTKTTLVEPNVSMDVLVQETMKAGLLPPVVMEFPGITVGGGFVGTAGESSSFKYGFFDQTVLSAEVVLADGALVTASASQNADLFEGLRGSFGTLGVLTMVEMQLIPLRQMVEVTYYPTFSFENATGKMKYHASDVRNDYVDGVVFSKDTGVIVTGRLIDTPTSTSSHLPVQRFSRPWDEWFWIHARTASSRGIITKELVPIQDYLFRYDRGAFWMGMYAYKHFMVPFTWLTRFLFDYFMHTRIMYHALHASGHTDRYIIHDIAFPADNAAPFLEYADEVFGLYPIWLCPLRRDGRSSMGHAKPFRGLVGGKQVDGYEDEDISVGLWGPYPSNEAEFVRANREIEAKMRELGGLKWLYSRVFYSEDEWWQIYDKHEYDELRRKYHATSLPSIWDKAKDRGRKQDFGTGSKGFLKRLVKSNAFLSGLYGIYKAVKGDDYILKKQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSR0</accession>
    <name>M2SSR0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_248548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704318.1">
        <property type="nucleotide sequence ID" value="XM_007706128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSR0"/>
    <dbReference type="GeneID" id="19135164"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_248548"/>
    <dbReference type="HOGENOM" id="CLU_1468032_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="184" mass="20110" checksum="838539F768FEBE65" modified="2013-05-01" version="1">MFLHVLLRSLAGMRRLRAEGGAWDQGMLEATAGWDGMEWNGTIQVKWVSRSRSWPWPRPWSCVPKRTGPLSSKPAWLSQLPAPANPTLSSQSSGRRFLAGLGACSAVKVQVQVKGACTGRHCPVNAHDACPRTKPPVYPIPSHACHYCPLSTARLPSLSCSSTPHCQLLNHSTNNSPLPQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU78</accession>
    <name>M2SU78_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_98957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703916.1">
        <property type="nucleotide sequence ID" value="XM_007705726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SU78"/>
    <dbReference type="STRING" id="665912.M2SU78"/>
    <dbReference type="GeneID" id="19141833"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_98957"/>
    <dbReference type="eggNOG" id="KOG3290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048953_0_1_1"/>
    <dbReference type="OMA" id="KYSEDNW"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36593" checksum="D82626C1EE6E7227" modified="2013-05-01" version="1">MAVQIAQGLTPEQLAFFNENGYLLIPDALSQDTVKELLNDTTQMLNDFSLDDHPMTKFSTGGEDGADHVGDSYFLESGDKVRFFFEEDAFDKSGNLTKPKHRAINKIGHYLHELSPSFRSISLSDRNAAIASSLGFRDPRVLQSMVICKQPEIGGAVPPHQDSTFLYTDPPSAVGWWYALEDATKENGCLSFAAGSHKRAPIEKRFVRTGNGTGFIDNDGAKFPNSIKPESQGEKGYEMVEKEEKYDMGEVKAGTLVLIHGNILHKSEKNTSEKSRNIYTFHVIEGDQKYDERNWLQPPAQGFSKLYQKTTAANGTNGPDSSNRLAKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUJ9</accession>
    <name>M2SUJ9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_159555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698982.1">
        <property type="nucleotide sequence ID" value="XM_007700792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUJ9"/>
    <dbReference type="STRING" id="665912.M2SUJ9"/>
    <dbReference type="GeneID" id="19131971"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159555"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_0_1"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF19">
        <property type="entry name" value="DUAL O-METHYLTRANSFERASE_FAD-DEPENDENT MONOOXYGENASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="323"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD65975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="555" mass="62678" checksum="F979929B020724ED" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVE4</accession>
    <name>M2SVE4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_149431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703362.1">
        <property type="nucleotide sequence ID" value="XM_007705172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVE4"/>
    <dbReference type="STRING" id="665912.M2SVE4"/>
    <dbReference type="GeneID" id="19131494"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_149431"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OMA" id="ESMRMYH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD61016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="52580" checksum="091D0F80550A3BEA" modified="2013-05-01" version="1">MAWNLVQRLRSNTFVEYICDEVLNTPGRTVEMNLLGGDIFITDRAENIKAIQADQFVDFAKGQTPHDVFSSILGDSVFTTDGPLWKTSREQLEPHVSRVRSDDIPTAEEHMQKLLRLIKNSPEKVDVYDVVDRFQLDLVSQVFLGESTNSLSANEQPFRKAMEELLTFNTNRLLFGRLANLFPDWLFVPRAYRELTRYINDLIDKTLALPINNQTDWKTKKEFNLVEDLVATHPNDRYFIRGQLIAVLMASKDPGAILTTWTIYHLARQPTLYKRLQQEIEKHIGMDRIPTVEQLRKLDLLANTVKESMRMYHPLGLNIREARKDTILPVGGGPDGSGPISVSAGQIIVYSVAGLQRNKTTVGADADIWDPSRWETWSPQYGHYLPFSVGPRQCPGRVFGRFQIQYILVRLLQEFESITWCGLNGIEDIGTEEMKIKVELNLKCAEPVICNFTPRRKNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVN0</accession>
    <name>M2SVN0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_39610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703070.1">
        <property type="nucleotide sequence ID" value="XM_007704880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVN0"/>
    <dbReference type="GeneID" id="19139530"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39610"/>
    <dbReference type="eggNOG" id="ENOG502SASY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089396_0_0_1"/>
    <dbReference type="OMA" id="QWFDARE"/>
    <dbReference type="OrthoDB" id="5363415at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018858">
        <property type="entry name" value="DUF2458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10454">
        <property type="entry name" value="DUF2458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="264" mass="29676" checksum="223AF41D25B9EEFA" modified="2013-05-01" version="1">MAQDGQQNPDLAAILATLASLPKPEAQPYQDQQAYEQNHSYQGYQDPQQHYQPEPSHQYQPPPDPRLAGRPAPQHRQPPPKPQDRVSSPLIDPSTITEWKQGLRCVSKIAAQNPDFAPAVRKLMKDQEANVKSWEAGRKKLIEEQKFQRENERTHRAALSLPGLLEGTALLRTPEREKEELDQYDAKVYRACKAMVDSQSSSLKVLGVPFFGVKPYLVLGASYDPMEVVDSQTVAVGGGGKITKEKLLELQRKMLNHLMELYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVQ6</accession>
    <name>M2SVQ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_98120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="236" mass="24970" checksum="A96AC303185435B0" modified="2013-05-01" version="1">MARIAPQKRKASHVDSVERGEGVPLGPQADRDAAKFGSAGVMMVKCVPRLGVGVVYICVQAPDGQILLSQQEVKGPHGTLCDMQSPPHLPPASTAGQDVIEPRLTGEAEMPAQSCLGVSALAVAPPPGHVRLIHGRLANHVCPSKPTPSRPKTRTKYKSTTKVLPFNSLVHLDLGHGFRKRRVRELFMPRQCSCGVTEACKPAGQVEAMALQGKLHDGTLLSTVGSCASRPSPCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWM9</accession>
    <name>M2SWM9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_354033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698118.1">
        <property type="nucleotide sequence ID" value="XM_007699928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWM9"/>
    <dbReference type="GeneID" id="19138278"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_354033"/>
    <dbReference type="HOGENOM" id="CLU_1731306_0_0_1"/>
    <dbReference type="OrthoDB" id="10677196at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="151" mass="16334" checksum="A3DC7121F38D27F4" modified="2013-05-01" version="1">MTVRRACFPKRSLLHRGSVGVEPGNLGAMQHPRPSSSWFSGKLEAPVTDATHASATLPITGPPRRDEARSCDRRLEQTQKPFLYTYPRSARACPKPPLRPLHTPSSSLFSPPPQPPPSATDNGCVCPSFVDLAPTKCPVTRLDADPSPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWN4</accession>
    <name>M2SWN4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_124853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703537.1">
        <property type="nucleotide sequence ID" value="XM_007705347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWN4"/>
    <dbReference type="STRING" id="665912.M2SWN4"/>
    <dbReference type="GeneID" id="19130607"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_124853"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OMA" id="AGMTHEK"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="264" mass="28061" checksum="AEC27848734C7C15" modified="2013-05-01" version="1">MSLSNAESPSLIVSIKDDGIAILELNRPKKRNALCQALIDELITALRQIDRNPTIFATVLTSSGPFCAGADLTELAKLTTAEATCVGWLKDLNEAFSSFRKPILAAVRGFALGGGFELALMCDMVYATADARFGFPEITLGTIPGAGGTQRLTKTIGKQKAMELILTGATTSATEMERLGVVNRAVPNGEDVLEVATAMARTIASFSAPAIGLAKQAVLAAETTTLKAGLEIERALYYSSFSLEDCREGVAAFKEKRKASVQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX09</accession>
    <name>M2SX09_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_192429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702828.1">
        <property type="nucleotide sequence ID" value="XM_007704638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX09"/>
    <dbReference type="STRING" id="665912.M2SX09"/>
    <dbReference type="GeneID" id="19133805"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_192429"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_2_1"/>
    <dbReference type="OMA" id="YSAMMVT"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="407" mass="45574" checksum="F3E535A56862E549" modified="2013-05-01" version="1">MGPGPEPYTISVPDEAIEKLKRKLSDADFPDELDTPDQWPYGSPLSDIKRLAKHWETKFDWRKAEAQMNQLPNYRKKIKVKGFGDIDIHFVHKKSNNPNAIPLLFCHGWPGSFLEVTKLLPLLESGSDSPAFTIVAPSLPNFGFSQRITKPGFSLTQYAETCNTLMQDLGYTCYVTQGGDWGFYVTRIMGLLYPDNVLASHINMVRAHAPSWTSQPLLALQHALTPYTASETAGLQRSAWFTGEGQAYRQLQATKPQTLSYAFADSPVALLGWIYEKLVEWTDGYEWSDDEVLTWVSVYWFSSAGPNAHVRIYYEAGHNPTPEVPDRERASGWVGKVKLGVAHFPREITVVPRVWARTLGPLVYESIHDKGGHFAAHERPDAIAEDLQKMFGKGGPCFGIVPGKPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXN8</accession>
    <name>M2SXN8_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_157501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696824.1">
        <property type="nucleotide sequence ID" value="XM_007698634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXN8"/>
    <dbReference type="STRING" id="665912.M2SXN8"/>
    <dbReference type="GeneID" id="19131829"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157501"/>
    <dbReference type="eggNOG" id="ENOG502S4JN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095059_0_0_1"/>
    <dbReference type="OMA" id="PHNDGEE"/>
    <dbReference type="OrthoDB" id="5344687at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="190" mass="21173" checksum="03763B4E76A756B4" modified="2013-05-01" version="1">MSECHEEWLREDPHPLLAQVPLTVSPFVSLPTATPLPYSYKSLPSTLPPSILSQQQQQQQNESSPSHHPHQQQEESTGAYVVSASGTSASPDQILSSCTALQAHLKQLEDDARRTLAQWEERRRAEDLAEKRRVAPGWLDSGVHILKPEGVDEDKGKDPQQQNLMDLDPQAEQKAKQGEELDRVFGGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXT7</accession>
    <name>M2SXT7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_201987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702906.1">
        <property type="nucleotide sequence ID" value="XM_007704716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXT7"/>
    <dbReference type="GeneID" id="19134209"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_201987"/>
    <dbReference type="HOGENOM" id="CLU_2298273_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="101" mass="11454" checksum="E603A8798A4B835B" modified="2013-05-01" version="1" fragment="single">ASRAHSKISLITHPPPISPSRSQLPLNKVQASLPWSPHPRPFLWPFTHLTRPLPSPHLTYGSPPALNRCVCLRWSKRREGFTPRAVKTRLRGGLRHSEQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXY0</accession>
    <name>M2SXY0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_146895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007704018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXY0"/>
    <dbReference type="STRING" id="665912.M2SXY0"/>
    <dbReference type="GeneID" id="19131392"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_146895"/>
    <dbReference type="eggNOG" id="ENOG502SRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831567_0_0_1"/>
    <dbReference type="OMA" id="HYNTYGH"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="334" mass="38726" checksum="66D6DA774E720EBB" modified="2013-05-01" version="1">MTIKSPSLFSRAHRPAIYPPKQLRGFLALPGEIRNQIYKYYFDREHHCEVAAKGSQFKQREPQTVKLCSGLSSQQDWTLRPGSESDNSLAPSVVRFSRSLGKYIMVHGLQTNWLSSLYALSLVCKQVHLETTKFLYCKTIFIFDAPKRMHSFFGVVSSTSLQNIKRLHLHYNTYGHPQRTDHQVWQDKHTQSWSKACKTASKKLINLQQLQIWVQIHDCAPKFSLREKWIKPLLQFRRLTYGKACTNDHVDNSVLLETVKIHIQTRWSKDPLGMFLNNQRLARASTELHVLYGQAVSLAIKGAREEEAMTAFNAAWEGKYKQWKHHLQFAPTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXY7</accession>
    <name>M2SXY7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_34043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696523.1">
        <property type="nucleotide sequence ID" value="XM_007698333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXY7"/>
    <dbReference type="STRING" id="665912.M2SXY7"/>
    <dbReference type="GeneID" id="19137416"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34043"/>
    <dbReference type="eggNOG" id="ENOG502SCD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013444_1_0_1"/>
    <dbReference type="OMA" id="HDMFCPA"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF56">
        <property type="entry name" value="GALACTOSE OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025455" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="116"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="702" mass="75612" checksum="ACA2E0B40B41A821" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXZ3</accession>
    <name>M2SXZ3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_39366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702633.1">
        <property type="nucleotide sequence ID" value="XM_007704443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXZ3"/>
    <dbReference type="STRING" id="665912.M2SXZ3"/>
    <dbReference type="GeneID" id="19139481"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39366"/>
    <dbReference type="eggNOG" id="KOG1570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_3_0_1"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="217" mass="24291" checksum="BE0C4850B24770B1" modified="2013-05-01" version="1">MSKISVAGVRTNVQQLLEYSNETKKRNFLETVELQIGLKNYDPQRDKRFSGTIKLPTLPRPRMSICVLGDQHDIDRAKHHGVDAMSTDDLKKLNKNKKLIKKLAKKYDAFMASDALIKQIPRLLGPGLSKAGKFPTPVSHNEDLANKMNEVKSTIKFQLKKVLCMGVAIGNVGMTEDELIGNIMLAINYLVSLLKKGWQNVGSLTIKATMSPPKRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2T004</accession>
    <name>M2T004_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">geranylgeranyl diphosphate synthase</fullName>
            <ecNumber evidence="1">2.5.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_156377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695660.1">
        <property type="nucleotide sequence ID" value="XM_007697470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T004"/>
    <dbReference type="STRING" id="665912.M2T004"/>
    <dbReference type="GeneID" id="19131757"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156377"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_10_1_1"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="502" mass="57094" checksum="2A478FB58716FE2E" modified="2013-05-01" version="1">MGAFWPMLSFSMGYEPAAQEHDLVQHVLEPIEEGICLTNDYWSWERELSDHLTNGNRINNSVDVAMRILNLDQATAKEWLKERLIGLECEYVQYKVEFYQEHPNLSLELRRWIELAGSIMRGMHYWASSRACHHGWKEHREQAQNTPLTQDGAQSCTHNTIEFEDNSSDQCSTASTSLTTPDLVNEFEIDKNIGSEGLNQIIELGGTSNQNPTQNENDRVLMRPIKYIASYLQMVDNFMFVRAVREASGLKNEVAVLLLLDGLERMYQGQTLDLYWKHTMMCPSISEYLHMVDCKTGGLFRMLLQLAKSENTVSYPSNLGLDTIVLLFGHFFQIRDDYMNLCSVEYGKQKGSCENFDEGEFSYPLIQLFDLLPECKDEVVGILKLSRRPNQKLPEHAKQQILDRMHASSAMDATRSFLRALEEKIDKEVEKDMVNNGTTLCLNRTVMVKYMNYAGDSWVGYDDVETIAMKEDFANSMCLGGTTIWSIGFDASAGGGGGSELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2T052</accession>
    <name>M2T052_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_222152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701898.1">
        <property type="nucleotide sequence ID" value="XM_007703708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T052"/>
    <dbReference type="STRING" id="665912.M2T052"/>
    <dbReference type="GeneID" id="19134609"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_222152"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="54"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD62561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="495" mass="51585" checksum="642C7A9113B21D67" modified="2013-05-01" version="1">MPATTTLLSRAGSQLTSRGSIALRGAFSPATCTARTPALSALARYYASKSYPPHSVINMPALSPTMTSGNIGAWQKKVGDSIAPGDVLVEIETDKAQMDFEFQEEGTIAKILRDAGEKDVAVGSPIAIMVEEGEDVSAFESFSIEDAGGDKKAASSPKQGEASEASEPPNNSGSKTAPPAKEQSAPAAIESDSTGARLETALQRQPAVSPAVKKLALEKGVPIGSIKGTGKGGAITKQDVENYKPAAGASSAAAAGPAYQDTEASSMRKVIASRLTESMQQNPHYFVASNISVSKLLKLREALNASANGAYKLSVNDLLVKALAIAASKVPAANSSWREEGGKVIIRQHNTVDVSVAVSTPVGLMTPIVKNVTGLGLQTISSQIKDLGKRARDGKLKPEEYQGGTITISNMGMNPAVERFTAVINPPQACIVAIGATRKVAVPGEASEDGTASIEWDDQIVITGSFDHKVVDGAVGGEFMRELKKAIENPLELML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0U9</accession>
    <name>M2T0U9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_222687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701953.1">
        <property type="nucleotide sequence ID" value="XM_007703763.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2T0U9"/>
    <dbReference type="GeneID" id="19134617"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_222687"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001872_1_1_1"/>
    <dbReference type="OMA" id="VKQIKLV"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000212">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000246">
        <property type="entry name" value="Putative Serine-threonine kinase SepH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000905">
        <property type="entry name" value="Ste ste11 cdc15 protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0283821-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="72"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1284"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1284"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1314"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1406"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1429"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1472"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD62627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1509" mass="166131" checksum="ACDA43B7DD65375E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1S8</accession>
    <name>M2T1S8_COCSN</name>
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        <submittedName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ND90Pr / ATCC 201652</strain>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42248" checksum="1BDFB040BEEDA047" modified="2013-05-01" version="1">MSSDTSSLATSHSSQFQDQLEVILDRLKTDPSSITADDARLLSENFNTHNERAVRIISAVEYLAIANKDLHVALGGSPEEVTTEVLRTTQSIVSKMQRALGHTNVPHPEVEGELQEEIVKIEPKIAQGTVTKAEADRLHSLEARAHGHTEKGGITAAAQSVVARRERQLSLSGGPEALQPSGSEQLQANKEGFKSPEQQSQYDKEGNLLQAADAVKDKIEEGTVTKAEASHLQSLKSRAHGDTFKGFIAATAQSTAARRESNASDARPCADSKNTLSPQEQPHHDKEENLRQVELAIRPKIQDGTVTAAEAKKLHSCEMRAHGHTEKGRLAATAQSVVAHRQRTLSDISNSPHPSETDAGPHKEDIDVDKEPKEVEGDLGDIAKTENEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3F0</accession>
    <name>M2T3F0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_27079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700343.1">
        <property type="nucleotide sequence ID" value="XM_007702153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3F0"/>
    <dbReference type="GeneID" id="19135610"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_27079"/>
    <dbReference type="HOGENOM" id="CLU_1562754_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="171" mass="19292" checksum="967FE1442AB73F86" modified="2013-05-01" version="1">MEGKVELRMMSMNIMDSGLVKISKQYTLNTTRKFLNGVLTSSSSLRRTVTGQMSKQNQSRRRLLRITLFQQPHFSSNYSNQPLSLASGPVRQLHPIKSSGGNDYAFDNLVHAITFLGDLRGKQEKYKQLNDILCKKTGFTSCYPISFQTYTGKAVANYNSSKLATLRPLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3X1</accession>
    <name>M2T3X1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_330879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700740.1">
        <property type="nucleotide sequence ID" value="XM_007702550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3X1"/>
    <dbReference type="GeneID" id="19137034"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_330879"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="OMA" id="YFFGFNY"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000426">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF152">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="58149" checksum="D50F220E2D3DF5FA" modified="2013-05-01" version="1">MTSQTNTDTARVLPSVPLLCFAAYFAYLIARAFYRLYLHPLAKFPGPKIAAVTSFYEGYYEIVLKGQYSKQISKLHDQYGPIIRVTPDELHIRDSRFFDQLYPKNVHLDKEGWDKRFGVADGVLATVNAEAHKRRRAALAPMFSRRSILDFVHIIYRHVDTLAHRMQEFEERAEPLNLTHAFPALTGDIIMDYFFGFNYNHLKNPEFESFHDAFTKIAGMGHLATQFPMILPIMDAIPDYITGWLQPAAKPILKFQQDHRALIARTLRGEDLKSNDAKKTIFQEILDSKLPPQDKSHRRLAEEAQVILGGGVETTAFSLAVATFHIINTPHIYERLHADLVAAFPNKNDLDLGVLEKMPYLKAVVMEAIRLSYGLSARNPRTHKTPLHYGDWVIPANTCISMTISDSSHDPAIFPNSTAFIPERWLGDSRTPDGLPLDRFMVSFGRGTRACLGVTLAWTEMYLVLGMMFRRYKYELFESSVADVEVGHDFFIPITSLESKGLRVFVKSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2T425</accession>
    <name>M2T425_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_207037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T425"/>
    <dbReference type="GeneID" id="19134336"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_207037"/>
    <dbReference type="HOGENOM" id="CLU_2291465_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="101" mass="11262" checksum="B9AAE90015A40579" modified="2013-05-01" version="1">MHVMPTPGRAKASHWHTATVETQRQPKRALPRRVIDALCNQLPTTKPNKQNWQSPALRRRRRHHAAAATLLLPLSGAVLLTPDNPGNPDNLLVFPARLDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5F0</accession>
    <name>M2T5F0_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_89214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700082.1">
        <property type="nucleotide sequence ID" value="XM_007701892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5F0"/>
    <dbReference type="STRING" id="665912.M2T5F0"/>
    <dbReference type="GeneID" id="19141290"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89214"/>
    <dbReference type="eggNOG" id="ENOG502SRCS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036307_1_0_1"/>
    <dbReference type="OMA" id="GMKRILH"/>
    <dbReference type="OrthoDB" id="5422958at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="67"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="257" mass="29221" checksum="68439175DA1AB4A6" modified="2013-05-01" version="1">MESNLSAARASRRFLDERIRNDWDYPDPAVEWSASDEQVRDAVDFRERYYGESESGDSDNEDQDGTPYKFDSPESIGDAVAHTREARKRRRRERMEREMKENEGLRIWVERRDVWTGAASVKKYGTIPETYDLVPVAPRLLDQNPIRASITPQAYSDIYQKIVVSSRTPSVPINLADMTKALVQGWKDADEWPPRVAAADPLAGKKRVITGPPSNGNHGGFIARHPHLEKGVDGMKRILHLNVQHNHENDYAQGKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6I7</accession>
    <name>M2T6I7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_90603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700313.1">
        <property type="nucleotide sequence ID" value="XM_007702123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6I7"/>
    <dbReference type="STRING" id="665912.M2T6I7"/>
    <dbReference type="GeneID" id="19141356"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90603"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_0_1_1"/>
    <dbReference type="OMA" id="SMTQFGQ"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="10">
        <location>
            <begin position="263"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD64572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="459" mass="49669" checksum="6697371E7C991797" modified="2013-05-01" version="1">MATKSEVPVYVLGVGLTKFIKPRQTRAYPEMGYEAGVKAMLDAQINYDDVDTGVACYCYGDTTSGQRIFYQFGMTGIPIYNTNNACATGSTGLHLARSLIKNGAIDCALVIGFEQMQPGSIKSVYSDRPSPMGLSMRMMADTRGITNSPPNAQYFANAGVEYMEKYGAEARDFAEIARISHEHSSRNPYAQFRDVYTLEQIEKSPMIHFPLTKLQCSPTSDGAGAAVLVSQKFLDARPHLKSQAILIAGQALMTDSPQLYSKSSMDLVGYDMTKRAAQAALKEAGVSPKDVKVAELHDCFSANELILLEGLGFSEPGKAHMMVRNGDITYGGKGPIINPSGGLISKGHPLGATGLAQCAELTWQLRGWANNRLAEGADVALQHNLGLGGAVVINVYKRADGNKNVKMSDDDVKRASQFAYNPAIEARYVTKEEGEKVRSKAAASEYALGDTLEKIQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6K7</accession>
    <name>M2T6K7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_22194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694093.1">
        <property type="nucleotide sequence ID" value="XM_007695903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6K7"/>
    <dbReference type="GeneID" id="19134604"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_22194"/>
    <dbReference type="HOGENOM" id="CLU_1061693_0_0_1"/>
    <dbReference type="OMA" id="WHEGAYS"/>
    <dbReference type="OrthoDB" id="3746467at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD70040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="262" mass="29962" checksum="BB66B49A76998B7C" modified="2013-05-01" version="1">MHRALTLPEVLLSIISYLPTRDLLTCHAVSSGWRRILIANLPARMRPLPDTPSSPLLQETTLVLPDSIRSLARSLNLRPKELVNWIVQPEVETDHLIWRDATTDELQEALGPYMHPLLAAHAYDLTGGVENVARGQMGLSIGTRMELGEFERMLEIRDDEEEGMKYLTQPVTKKVEVRCLDGAEWNEEYMNVRAIEGEMEWLRKCVRVERESGVRMCDVIDELRGVIEADWIVQHGSGNVLLDWRMGDNPERHSFHAFDRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T725</accession>
    <name>M2T725_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_342396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695325.1">
        <property type="nucleotide sequence ID" value="XM_007697135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T725"/>
    <dbReference type="STRING" id="665912.M2T725"/>
    <dbReference type="GeneID" id="19137540"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_342396"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1214647_0_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD70220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24302" checksum="5E5601A34EEF4FFD" modified="2013-05-01" version="1">MPGRMAHMQQVKWATAYAAMLSTTLLFALDNTIVANIKPAVINDFGHLELLSWIGTGFALGTMFILLWGKIYGVFNIKWVYIFNIVLFEAGIALCGVTPNMTALIIGRVVAGIGGSGMYSAQDLGMILFLAISGSLFHNVAVDKFGKALPDFSEKEIGNLIAESSSKASQALSGTEKTLMTPEIASAMTTIWAFFLAAAALSVLCSLPLLSRFADTWVVIGSKLGGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7C9</accession>
    <name>M2T7C9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_36465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="eggNOG" id="KOG0166">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 6 8" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
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            <end position="366"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="554" mass="60724" checksum="91DA9EBC266849AB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">COCSADRAFT_317071</name>
    </gene>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7V3"/>
    <dbReference type="GeneID" id="19136502"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_317071"/>
    <dbReference type="eggNOG" id="ENOG502S6U5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074873_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="157"/>
            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="226" mass="25097" checksum="CF9F0994486BEB32" modified="2013-05-01" version="1">MSNRKERRAKGTAFNAKATGGGLQPSTEIDQDGVEMILRHPDFSKPKGKTLFDLAEERQRELDELNPARKAARAAAMASRPVGDDQGPPIGPFGDSVLYSVSMAALHLTLDVLVYNQYREDIIWTEIVSRAATAWPIFAVLVYLTHVDISYRFPKVRDVVFFAGSIAAGCYLVYSGNQHGYFYVMKSAPPVGTLWIWSVVEMSLPFAATSALAVFGYIYWNGFQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2T926</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_305553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T926"/>
    <dbReference type="GeneID" id="19136263"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_305553"/>
    <dbReference type="HOGENOM" id="CLU_1786520_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="176" mass="19082" checksum="3FFD3E7E093ED35C" modified="2013-05-01" version="1">MVKEAERRREQRLENCAFLSSPVLPSSWWCDSACGYSRERPQLLRQLPACFLSPPRDPTQSYPSLALGGTFQVFLFFSFLLPSLLAISSFAPITRPGLRGPSAWEVALSIACSMAVGGGGATPPTDSAVATKGVEREVRNAGEWSGQGMAWSGTQEQNCRERPFSLFCTVCAAAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9R8</accession>
    <name>M2T9R8_COCSN</name>
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        <recommendedName>
            <fullName evidence="9">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_35692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698381.1">
        <property type="nucleotide sequence ID" value="XM_007700191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9R8"/>
    <dbReference type="STRING" id="665912.M2T9R8"/>
    <dbReference type="GeneID" id="19138468"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35692"/>
    <dbReference type="eggNOG" id="KOG3066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067225_2_1_1"/>
    <dbReference type="OMA" id="DTCMETC"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD65657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32926" checksum="E5025E01AC0DE349" modified="2013-05-01" version="1">MADEKPEQSSSPFVSMFEGFRAELDEHHDRRERIIKASRDITASSKKIIFTLQRVRAVGQALPPWVTKKNAEYWETIQDRYKSIAADLQELNAYRYSHNITGGNQEFMEALSFQHYLETQSLISYDEAKSRIASMSGEAGPIAFTSEDYILGVCDMTGELMRFAVTSMATSGKLPSGKQAESNKRLKQEHDQEDGGDRMEIDEQTPAANETQKPRTVLDDLRAVRLQLEMFEVPGGSKFAAELEMKKMPVMRECVDKVEKGLYGLTVRGNERPKGWMPDMSSGRGNEVESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_355053</name>
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    <organism evidence="1 2">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9W3"/>
    <dbReference type="GeneID" id="19138334"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355053"/>
    <dbReference type="eggNOG" id="ENOG502SP1S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490887_0_0_1"/>
    <dbReference type="OMA" id="PLWCLKL"/>
    <dbReference type="OrthoDB" id="5368934at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="552" mass="60441" checksum="6214F588BF889F33" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TA47</accession>
    <name>M2TA47_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_140174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lucas S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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        <location>
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            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="184" mass="20828" checksum="FC3B76CD1100A39C" modified="2013-05-01" version="1">MEPSTPRSIRLVVFFFMVLIGLWNFFLNVAARYKEHPFNHINGFPLWALNIITSTVYVACTVVYISMTWHYAKEHPYWSVFSLVLALLMTGSMIWAGLDLFDWFVWGPLVVDLAIIVRAGIEEVANSVESGLLRKTWNGFWGYETLPPQPPPQQQPQDDAHDPELGLEGAHQLANLDAQPGNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2TD15</accession>
    <name>M2TD15_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_285123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696867.1">
        <property type="nucleotide sequence ID" value="XM_007698677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TD15"/>
    <dbReference type="GeneID" id="19135877"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_285123"/>
    <dbReference type="eggNOG" id="ENOG502SY9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2670970_0_0_1"/>
    <dbReference type="OMA" id="YCSSQYL"/>
    <dbReference type="OrthoDB" id="4400538at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="76" mass="8611" checksum="ED954C38373CA5B7" modified="2013-05-01" version="1">MALSTHAMSHIRRYSTRMPRDPHYRLKASLATSYVVTACALPFVPPLLETRRAKADGSWMTKESMHCSSQFLGCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDW0</accession>
    <name>M2TDW0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_33846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696475.1">
        <property type="nucleotide sequence ID" value="XM_007698285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDW0"/>
    <dbReference type="STRING" id="665912.M2TDW0"/>
    <dbReference type="GeneID" id="19137335"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33846"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_3_1"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD66927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="411" mass="43804" checksum="122BDB4A45CF9FAD" modified="2013-05-01" version="1">MTLADHPIDTPPRPASPVHRFGTLAVHAGSPHDPVTGAVIEPISLSTTFAQTSVGQPIGEYEYSRSSNPNRDNFEKAVAALEHARYALAYSSGSAATANILQSLAAGSHVVSVSDVYGGTHRYFTKVALTHDVKVTFSPSIEIDIAELIRPNTKLIWIESPSNPTLTLVDIRKVSTIAHQHGIMVVVDNTFMSPYVQNPLDHGADIVVHSVTKYINGHSDVVMGAAAFNSEQLYERLSFLQNAIGAVPSAFDCWLAHRGLKTLHLRAREATKNATGVAKALEASQHVISVNYPGLKSHPQHAIALKQHRDGMGGGMLSFRIQGGHTAAERFCQATKIFTLAESLGGVESLVEVPSAMTHGGIPKEQREAAGVFDDLVRISCGVEDEADLVADVVAALEKAVVGGKIHNGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEZ5</accession>
    <name>M2TEZ5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_288335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEZ5"/>
    <dbReference type="GeneID" id="19135922"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_288335"/>
    <dbReference type="HOGENOM" id="CLU_2573556_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="85" mass="8557" checksum="6B334287C87382E3" modified="2013-05-01" version="1">MFIPPIRFAPFQVSRPNSTSNTSTSNSSTTSSVASPQASTQNATHTPYDTSSATYSSSKTTSSSGAGPEGQMESSGGTMGAQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF44</accession>
    <name>M2TF44_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_293938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697408.1">
        <property type="nucleotide sequence ID" value="XM_007699218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TF44"/>
    <dbReference type="GeneID" id="19136041"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_293938"/>
    <dbReference type="HOGENOM" id="CLU_2298243_0_0_1"/>
    <dbReference type="OrthoDB" id="3689917at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="113" mass="11953" checksum="3756E747C652C40E" modified="2013-05-01" version="1">MRLELPRSRVGGLAGVCWVDGATGAREPGDARRTGPSDTCSPIEPKPHVWVGREQQQGHGLVDVKRKKRVQISPTQPTAGGVRGGSQGRRGAQFRARATAGACACVLGLQKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFL0</accession>
    <name>M2TFL0_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_33001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695432.1">
        <property type="nucleotide sequence ID" value="XM_007697242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFL0"/>
    <dbReference type="STRING" id="665912.M2TFL0"/>
    <dbReference type="GeneID" id="19136997"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33001"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="MRFAFKL"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="11"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="368" mass="40293" checksum="6B78D7F9EA7A5349" modified="2013-05-01" version="1">MSPSTTTRTHSIATIGADGIGPEVVNAGVQVLRKLAQLDGSFQLQFKDYDWSSETYKKTGKYIPDGGLEELKKHNAILFGAVGAPDVPDHISLWGLRLAICQTFQQYANVRPTKIFRGTSSPLRKAEHGDLDWVIVRENSEGEYAGQGGRSHKGQPWEIATEVSIFTRHGVERLLRFAFETARKRPRKYITVVTKSNAQRNGMVMWDEVAAEVAKEFPDVKCDKMLVDAMTCRMVLDPKSLDTIVATNLHADILSDLAAALAGSIGIAPTSNLDPTRQNPSMFEPIHGSAFDITGKGIANPVGTFWTASEMLAWLGEEQAAQKLMESVESVTERGVTTRDLGGSSSTNEVTDAVCFQLERIYGVSSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGP5</accession>
    <name>M2TGP5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_132964</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695661.1">
        <property type="nucleotide sequence ID" value="XM_007697471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGP5"/>
    <dbReference type="GeneID" id="19130877"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_132964"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_1_1"/>
    <dbReference type="OMA" id="NWYAVLP"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="14">
        <location>
            <begin position="113"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD67897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="379" mass="41651" checksum="7AE4CF59DB6C14C8" modified="2013-05-01" version="1">MHQQASCIDMPAMPSGIKEIPVQLPKSFDRPDEPWHHYLTIDLIWYVFGYTIFHPFVSWVVVLCLRAQYTPYGNLEMRLATAWAMLMSIIGIFGLLSDRIAFGPPREVDLAEEVIVVTGGVEGLGALLAETYGMRNANIAVLDTKKVDDEVSENTGVLYYECDVSDAKQVEAAAAQIVEDLGAPTILINNAGIMQPKSVLDSTAEEVERTFRVNTLAHFNTLRTFVPHMLKEGRGTIVTVASVLGHLGAANLSAYTASKAALLALHQSLRAELAQNPDAKHIKTILVTPGQMGTRMFADLKTPSNFLAPIVTPAEIGKDIIRMIEKGDSGEIAVPLYSRYIQVLGVLPFGVQHLIRKLSGMDKAVGRMKEVRQEPKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2THX7</accession>
    <name>M2THX7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding module family 35 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_350550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696329.1">
        <property type="nucleotide sequence ID" value="XM_007698139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THX7"/>
    <dbReference type="GeneID" id="19138030"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_350550"/>
    <dbReference type="eggNOG" id="ENOG502RISE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1408625_0_0_1"/>
    <dbReference type="OMA" id="REVECFA"/>
    <dbReference type="OrthoDB" id="3769880at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025961" description="Carbohydrate-binding module family 35 protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="19804" checksum="FD6A572828743FE6" modified="2013-05-01" version="1">MLFLPTLLLTSTTTTTLASPLPFSNSCTPNNLLQNPSFESNPSDLTPWLSLATGSFSSRTLSRDNPGGHNSATAYIASCNSSADILSTLTLSQSYIEVAGGKTVECYAWVRRGEAGKGRARVEVFLDGGSCGGVVEVGEGQEEWVKVGGKVVVQDVGAGGVGHTVAVTVQGYGAEGDGGWSVAIDDVGVVVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2THY5</accession>
    <name>M2THY5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_168032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THY5"/>
    <dbReference type="GeneID" id="19132551"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_168032"/>
    <dbReference type="eggNOG" id="ENOG502S30I">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="5596992at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
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    </dbReference>
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        <property type="term" value="F:rRNA methyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SAK_HAD"/>
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    <dbReference type="PANTHER" id="PTHR10335:SF23">
        <property type="entry name" value="OB FOLD-CONTAINING PROTEIN, NUCLEIC ACID BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HAD_SAK_1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="56"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="536" mass="59817" checksum="8001F8B21AE46AFD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ72</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_341135</name>
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    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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        <property type="nucleotide sequence ID" value="XM_007696450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ72"/>
    <dbReference type="GeneID" id="19137455"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_341135"/>
    <dbReference type="eggNOG" id="ENOG502SP7J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="249" mass="28456" checksum="5DE5F528A3B6747E" modified="2013-05-01" version="1">MTEQDAAEVFRLLKAGTDIDSIVKHVRDGNLLLQLPLISETIYQNEFLYMAKMPSHLFVIDNSHISSCLYKVVSSSSAYTHAENRQLTTKYGSAYMMPYHTTKMVEPLIDKITTTPWTMVTSDNRLLRRLISLYFIGPHPCAPLVHKDLFLEDMAAGGTSFCSPLLQMCIDVPDRVKVWHPESLIYRFLAEARRLWDLELMETLRITTIQVALVLSLTYISNSLDTLSTFFLEQAITMGERLHLFDVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJX9</accession>
    <name>M2TJX9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_32183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694225.1">
        <property type="nucleotide sequence ID" value="XM_007696035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJX9"/>
    <dbReference type="GeneID" id="19136672"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32183"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023630_0_0_1"/>
    <dbReference type="OMA" id="HYAEHFG"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000251">
        <property type="entry name" value="Extracelular serine carboxypeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026032" evidence="6">
        <location>
            <begin position="20"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="548" mass="62071" checksum="00F694BE96DA6616" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLT2</accession>
    <name>M2TLT2_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_177725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695248.1">
        <property type="nucleotide sequence ID" value="XM_007697058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLT2"/>
    <dbReference type="GeneID" id="19133101"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_177725"/>
    <dbReference type="eggNOG" id="ENOG502S4DW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332880_0_0_1"/>
    <dbReference type="OMA" id="KSTIPRC"/>
    <dbReference type="OrthoDB" id="3790379at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD70116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="859" mass="92642" checksum="B77309A19018E6EC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TMR8</accession>
    <name>M2TMR8_COCSN</name>
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        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_78220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695164.1">
        <property type="nucleotide sequence ID" value="XM_007696974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TMR8"/>
    <dbReference type="STRING" id="665912.M2TMR8"/>
    <dbReference type="GeneID" id="19140652"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_78220"/>
    <dbReference type="eggNOG" id="KOG2613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="251"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="315"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD70007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="508" mass="57976" checksum="2EF777558E4A2391" modified="2013-05-01" version="1">MTDAQSFAPAPKNAATILCADCGAPVDGTISGAFCYDCIKLKTDVTGGIQREAILLMCRDCDRWLSPPSTWVVAPPESRELLALCLRKLRGLNKLRIIDASFIWTEPHSRRIKVKITVQSELNEGAIMQQTFEVEYTQNYNQCPDCAKSYTHNTWRACVQVRQKVPHKRTFLYLEQLILKHGAHKDTINIKEVHDGIDFFFAQRNHAVAFCDFLKAVIPVNIKRSEELISHDIHTSTKNYKFSFSCEIVPICKDDLVVLPIPLAKKIGNISPLTLCSRIGTSVQLLDPATLQTADVATDIYWRTPFRPLADVQELTEFVVLDIEPLGKQSGRNFLAEATVARASDMGVNDTTYYCRTHLGGILHVGDSVMGYLLANTNFNNDLFDVLEQNNKYASAIPDVVLVKKYYQRSRKSKNKRNWRVKRMHKEEGEMLPRKQDQEKMERDFEMFLQDVEEDQELRQTMALYKAQQQRDADAMETESSLGDDEDEGIQIPMDQLLDDFEDMKMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2QUW9</accession>
    <name>M2QUW9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_128629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705394.1">
        <property type="nucleotide sequence ID" value="XM_007707204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QUW9"/>
    <dbReference type="GeneID" id="19130721"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_128629"/>
    <dbReference type="eggNOG" id="ENOG502RR5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679692_0_0_1"/>
    <dbReference type="OMA" id="LEQMHEG"/>
    <dbReference type="OrthoDB" id="3794317at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="372" mass="40791" checksum="5C103CC7C4F3E306" modified="2013-05-01" version="1">MSQPNTPFDGATEDPFLSSSDQFSQADFEELFGSGGSDGDIFSSNNSEVFDGTNFTYGDALLVPVDSSSLSVISTPEPSAHSSNRRSLAYPTPEVDKPHPYPFETNRPYEASIPQSIFNSRPFPIRSETNNVHLYSTQLVQPASRRRSLSHGDMDRVVAASIPNPTFIRLQAPRARTIPEELRGRDLHLRCGMLLTPIGTPLNVVEGTDCDTNITHQNHSIENNNPFFPSFTEGLLFRQMSRPEELARSRQIIEIGALAVTSHSSIGPRLQPYTSASNQERISKKLVNIEEHLGKSGGAEALRSCKTIRKVLIGTTECEEETKGMDGVLKDDGNTAANIPKEAYSDLSNGCDDNETMAMLMSQHGVREGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2QXK2</accession>
    <name>M2QXK2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_254294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704768.1">
        <property type="nucleotide sequence ID" value="XM_007706578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QXK2"/>
    <dbReference type="GeneID" id="19135282"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_254294"/>
    <dbReference type="HOGENOM" id="CLU_2061310_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="119" mass="13343" checksum="6998B4710135F3E1" modified="2013-05-01" version="1">MQHASVPQPKPRVCIESMTISMGSLRRQSHPALYFQLHPTDLLSPPKETIPRTDTCFANCLSRSTACSQLAQLMSRDAPNLAPAPFPRRTYYHVNSNSTRTSRSRPLRLTLLLNAFACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2QYR3</accession>
    <name>M2QYR3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial outer membrane protein porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_40587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704128.1">
        <property type="nucleotide sequence ID" value="XM_007705938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QYR3"/>
    <dbReference type="STRING" id="665912.M2QYR3"/>
    <dbReference type="GeneID" id="19139783"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40587"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044399_0_0_1"/>
    <dbReference type="OMA" id="FKQPAFH"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD60154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31078" checksum="0BC7B12DCCB78A31" modified="2013-05-01" version="1">MPEYVKVESIIPKVPPPAFSDIAKASNDLINKDFYHTAAAALEVKLKAPNGVNFTAKGTSAHDGPVTSSLEGKKSLSNGISITQSWNTANLLATKVELNDTFASGLKTEVLSNFSPAAGNKGQKVNLHFKQPAFHGRAFVDYSAAGAIGTTADAVVSHEGMVVGGEVGYDVQKAAITKYSAAVGYTTPLYNAAVTATNSLSVFTASYYQRVNPAVEAGARAVWDSKSGNNVGLELAAKYKLDPLSFAKAKINNLGIASLAYNTKVNSGLTFGIGGSFDTQKLNEAGHKLGTSFTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZM4</accession>
    <name>M2QZM4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_243882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703851.1">
        <property type="nucleotide sequence ID" value="XM_007705661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZM4"/>
    <dbReference type="GeneID" id="19135065"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_243882"/>
    <dbReference type="HOGENOM" id="CLU_2454559_0_0_1"/>
    <dbReference type="OMA" id="VHRARQC"/>
    <dbReference type="OrthoDB" id="10355807at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="105" mass="10929" checksum="C66BDE9549CCFA6B" modified="2013-05-01" version="1">MAQPLRYAAPTPPIVLVAASASMATVNITLLAKSKSNQLNDDAKKGLADRVHRARQCQRGSVARAPSTDPKSDADTDACPSSQDLGAPSYSRVSLVGESGVHGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2R1B0</accession>
    <name>M2R1B0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_238856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703392.1">
        <property type="nucleotide sequence ID" value="XM_007705202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R1B0"/>
    <dbReference type="GeneID" id="19134944"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_238856"/>
    <dbReference type="HOGENOM" id="CLU_2527302_0_0_1"/>
    <dbReference type="OrthoDB" id="10399497at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9999" checksum="42BB7EB97EBD98AD" modified="2013-05-01" version="1">MPPRRNNNTNATPTPILPTHNQHLQTESQKAFSNRRHRHRRAVPWYRRSENVWRSRLETASHFGIFLAALLTLVYFLRRGDAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2R358</accession>
    <name>M2R358_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_183622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702933.1">
        <property type="nucleotide sequence ID" value="XM_007704743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R358"/>
    <dbReference type="STRING" id="665912.M2R358"/>
    <dbReference type="GeneID" id="19133425"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_183622"/>
    <dbReference type="eggNOG" id="KOG2484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_5_5_1"/>
    <dbReference type="OMA" id="FKLDGLW"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000006">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000844">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
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        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="184"/>
            <end position="365"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
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        </location>
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            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
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            <begin position="1"/>
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    </feature>
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            <begin position="56"/>
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        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD61639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="534" mass="59269" checksum="CBDC88AD4F3B436B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2R5K5</accession>
    <name>M2R5K5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_146243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R5K5"/>
    <dbReference type="GeneID" id="19131371"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_146243"/>
    <dbReference type="HOGENOM" id="CLU_1019441_0_0_1"/>
    <dbReference type="OMA" id="CKYVAPL"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36259" checksum="52764E0E65C59D1E" modified="2013-05-01" version="1">MAQTSPFLTLPGEIRNQIISYAFNRAPGSIPASSLSKSALALAWTCRQLYAEYASLARSHSVIYPLKWLSAQQLAEKTRALLATACAPQVTKLQILLPACLGELYICDSSATTRRRVKGFHFAAAGLPNLEELYFRFQSTDSHGNGDGSGSGGAGRELVVHMLWRLLWEKDLSRLNKICIVHDGAQPFLSLTLLHGMLVTFKPLYVSRRWHIKSDFEHGRLVFVEKSGDKTKRRITVLVGYSFHEAEEYVNVCEDIIEDKHADVVIARRRDCKYVAPLEEMTDADLRQEVDNLHTLFPVSATEEPLLQPHIEKIRARCNPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2RAB4</accession>
    <name>M2RAB4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 10 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_331954</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 10 11"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700828.1">
        <property type="nucleotide sequence ID" value="XM_007702638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RAB4"/>
    <dbReference type="SMR" id="M2RAB4"/>
    <dbReference type="GeneID" id="19137087"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_331954"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_0_1"/>
    <dbReference type="OMA" id="VDWTNCG"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023896" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="40"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD63824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="229" mass="25001" checksum="AB1DEFB500038B7E" modified="2013-05-01" version="1">MVAFSSFLLALSSASAVIASPLGLVLDAKARHEATSLSTRSTQPGTGVDNGYFYSFWTDGQGQVTYNNGPGGQYSVQWNNVNNFVAGKGRNPGTTQPFTYSGTWNAQNVNSYISVYGWTRNPLVEYYIVEAYGSYNPSSAAQIKGSITIDNGTYDILQTTRYNQPSIDGTATFQQFWSVRRQKRVGGTVTIQAHFDAWSKYGLKLGQHNYQILATEGYQSSGSASITVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RFL8</accession>
    <name>M2RFL8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_180298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698664.1">
        <property type="nucleotide sequence ID" value="XM_007700474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RFL8"/>
    <dbReference type="GeneID" id="19133242"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_180298"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OMA" id="SWHIWAL"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD65549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="510" mass="58536" checksum="3697A75AAF2AE1B4" modified="2013-05-01" version="1">MGVPQDVSATLVPATSTIRSDEEVTVKPHKWYYYLWDTLDKPKEERWFMFKLDAALLTFASLGYFIKYLDQMNINSAFVSGMKEDLGLYGNQLNYMQTCWTVGYVIGEIPSNIILTRVRPSIWIPTMELTWAVLTFCLCRAKNAETIYALRFLIGLAESTFYPGMQYIIGSWYRKEELAKRSCIFHTSGAIATMFSGYLMSGVYRLDGKGGFRGWQWLFIVDGIISIPIAIMGFFFLPDLPEISKPFYLTKEEVKFAQERMQREGRQKRQPYTRAKIWKIFTSWHIYALVFLYIFFNNGNSSAQPVFQQFLKSSKNPKYTVTQINTYPTATNAVQVVTTLLYAWTSDSILKGSRWQPIVFGGCVNIMCYTSLAIWDIPIKWKWACYILTGFGGGISGLCYAWAHEICTHDNEERAIVVASMNEMAYVVQAWLPLVVWKQVEQPRYHKGFITATCLSFMMIVTALMTRELHMRELGQRRKAQEEVYVPQSSAGGEEAGSDVDADLMFRKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2RI14</accession>
    <name>M2RI14_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_34949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697539.1">
        <property type="nucleotide sequence ID" value="XM_007699349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RI14"/>
    <dbReference type="GeneID" id="19137962"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34949"/>
    <dbReference type="eggNOG" id="ENOG502SQKC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077468_1_0_1"/>
    <dbReference type="OMA" id="SFLNCIG"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="226" mass="25716" checksum="739968482E64683B" modified="2013-05-01" version="1">MGSCQNENPSPTRTTTANFFDLPKKARENIYKRLLILRSPIYIFQEPNSPIESFAPDRPFRWLALLRTNRQIHTESSAVLYGMNQFHLVEITPIQAELLKSFLACIGPANSASLSYLCVNFTVAERLGGKTGMIKLTTDSTQTLRLYRDKCAQLSTLETVVHYKNSGFFRESDDFLQNALPFIDKQLRTIPSLHKIIVRFLDFHGIPTAFAKDLMEGLGWIVVLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RL72</accession>
    <name>M2RL72_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_157796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697074.1">
        <property type="nucleotide sequence ID" value="XM_007698884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RL72"/>
    <dbReference type="GeneID" id="19131852"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157796"/>
    <dbReference type="eggNOG" id="ENOG502QSCW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_2_0_1"/>
    <dbReference type="OMA" id="NEVMGDN"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024568" description="Beta-xylanase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="8">
        <location>
            <begin position="30"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD67409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="331" mass="36216" checksum="E10AEB5007FE6DB1" modified="2013-05-01" version="1">MKFSLITILSASALVAASPFAEPEAFLEERQAAQSLDAAMKAKGRKYFGTATDPGRFNQGKNAAIIKANFGQITPENSMKWDATESTRGKFTFGTADQTAKFAKDNGKLIRGHTTIWHSQLPGWVSSIRDKATLTTVMQNHISSVMGHFKGQIYAWDVINEMFEENGSFRASVFYNVLGEDFVRIAFEAAKKADPSAKRYINDYNLDTANYAKTQALAKNVKKWIAAGVPIDGVGSQTHLTSGQGAATIDAMKLLCSVASECAMTEVDIQNAQQADWTNVTKACLNQKNCVGITVWGVKDSDSWRPQGNPLLFDNSFNPKQAYTTVLNALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RMS6</accession>
    <name>M2RMS6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_107810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695687.1">
        <property type="nucleotide sequence ID" value="XM_007697497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RMS6"/>
    <dbReference type="STRING" id="665912.M2RMS6"/>
    <dbReference type="GeneID" id="19130038"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_107810"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_1_1_1"/>
    <dbReference type="OMA" id="ARQYPQM"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="187"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="354" mass="40146" checksum="C8A72219747E3B05" modified="2013-05-01" version="1">MEPSRTTQAAVILSAFVMPILTYLYFTKTQQSKKKAGPLPLPTEITSLFIHPIKSCHGISVQSAKLLPTGLDLDRQWMWVSYPEYEFLTIRQNSKMTLIRPTYDETTDTLTVTAPAPNSIDEKLEFSIPAHPSKEWLDENTEDHSAKIWSTTTETRVYCPELTAPFNAFFDRDVRLVYKPPVSDDPRPLVSNGAPAVLGRDASTCFPDLMPILVGNKSSIDELNTRLKAAADHTIDVRRFRPNIVVKGDSNAPWDEDRWKTIEITPMSGEKPIILDITQRCARCQVPNVDPDTAEKHKTQPWDILMKYRRIDEGITYKPCYGMLAVPRTVGEVRVGMKFEVTEVTDEHRYIAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSM8</accession>
    <name>M2RSM8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_351251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445659">
        <property type="protein sequence ID" value="EMD58248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706062.1">
        <property type="nucleotide sequence ID" value="XM_007707872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSM8"/>
    <dbReference type="STRING" id="665912.M2RSM8"/>
    <dbReference type="GeneID" id="19138078"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_351251"/>
    <dbReference type="HOGENOM" id="CLU_1320792_0_0_1"/>
    <dbReference type="OrthoDB" id="4357141at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="99"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="208" mass="23472" checksum="222D56520065F40B" modified="2013-05-01" version="1">MDPASLALAQSLPMSVRRTYTALAEYSDVPISRTTFEVIGPELCRPDILPENVYNMDETGVMLSMLGSIKVLVGKNNRRDYRGAGVKRTMVTAVECVSMKRVFDHQTKARANQKPRMLICDGFGTHETLEILEFCFKNNITLCRLPSNTSHKLQPCDVAVFAPLKTAYRDQVERLYRGGMTAINKEHFTALYYPARERVMTMKNILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUF6</accession>
    <name>M2RUF6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_185347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705294.1">
        <property type="nucleotide sequence ID" value="XM_007707104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUF6"/>
    <dbReference type="STRING" id="665912.M2RUF6"/>
    <dbReference type="GeneID" id="19133496"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185347"/>
    <dbReference type="eggNOG" id="ENOG502QU2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="OMA" id="APNGMYE"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="116"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD58793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34718" checksum="E00A5D09FCF3BF71" modified="2013-05-01" version="1">MSERNSAVSGNKEHKFNPNFTDAVINATGPNATPRVRQLAAGLIRHLHDFARENELTVDEWMAGVQLMNEAGRMSDSKRNEGQLICDVLGLESLVDEITYKLASTAADEPTATAILGPFYRENAPELPMGSCIVSKEINEQGDRTWMHGTVTDLKTGEPIEGAVVDVWHTAPNGLYEQQDPNQPDMNLRGRFTTGKDGTYSFYCLRPVPYPIPFDGPAGKVLQALDRHPMRPAHIHFLLTAPGYKPIVTQIFDRKSKYLDDDAVFAVKDSLVVDFKPFEGDPKADFELPYDFKMASFKDAEKHSVAGTTEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXE2</accession>
    <name>M2RXE2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704512.1">
        <property type="nucleotide sequence ID" value="XM_007706322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXE2"/>
    <dbReference type="GeneID" id="19139859"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40885"/>
    <dbReference type="eggNOG" id="ENOG502TG81">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2291470_0_0_1"/>
    <dbReference type="OMA" id="QWCASAS"/>
    <dbReference type="OrthoDB" id="10503485at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="101" mass="10536" checksum="ED37ACC14395CDCC" modified="2013-05-01" version="1">MPLALRRVCNMQGAALVVVVVVKVAPVPGRHGGGQRTAGVAAFAVFFLCFFFSLLLLRSGLRVVESDQGAMCQWCASASRARVAFIAQEGGPGARGEEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZL0</accession>
    <name>M2RZL0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_125366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703824.1">
        <property type="nucleotide sequence ID" value="XM_007705634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZL0"/>
    <dbReference type="STRING" id="665912.M2RZL0"/>
    <dbReference type="GeneID" id="19130623"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_125366"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_9_1_1"/>
    <dbReference type="OMA" id="METDNGY"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000078">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="141"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD60488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="556" mass="59114" checksum="4A4501CA5C74D368" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2S2X8</accession>
    <name>M2S2X8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_162980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702858.1">
        <property type="nucleotide sequence ID" value="XM_007704668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S2X8"/>
    <dbReference type="STRING" id="665912.M2S2X8"/>
    <dbReference type="GeneID" id="19132213"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_162980"/>
    <dbReference type="eggNOG" id="KOG2980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026938_0_0_1"/>
    <dbReference type="OMA" id="PAWRMLN"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="399"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="187"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD61538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="596" mass="66967" checksum="1D08A55D7007450D" modified="2013-05-01" version="1"> </sequence>
</entry>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S4Q2"/>
    <dbReference type="GeneID" id="19134725"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_228390"/>
    <dbReference type="eggNOG" id="ENOG502R8Q8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000016934">
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    </dbReference>
    <dbReference type="GO" id="GO:0003676">
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        <property type="evidence" value="ECO:0007669"/>
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        <location>
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            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62128.1"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27074" checksum="AF444319080BBF29" modified="2013-05-01" version="1">MIRLGTVHNETCDLVELETTPSRIKGSTSESRQELPRDVDGDFELACGGPDTPYPPFHSLACQPTPHTRCMGPAVPFGMGPTSRLCTRSAGTLSPEIVLYAVALMLEASSCKWEHVKSWSTYLFSSNTDEFHDKREVGNMIRNENEQLIGTGGYVIGDKDKKHQLARRLILSNLAADADEESIVVFLAKYRSNIRRVTLLSERDPVKGTRTAHVDMDSRRAAVYASFQHGHIFGLVVKIKLAVE</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="67" mass="7532" checksum="B9DEBE62D43B0A8A" modified="2013-05-01" version="1" fragment="single">VELLLTAQLAYNSIKSAMTKYSPHYANYGYKPTAHQDPKDIESIAIGADDKAKLMRELYKELSKNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6X6</accession>
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    <gene>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445722">
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    <dbReference type="GeneID" id="19129939"/>
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    <dbReference type="OMA" id="MNARHES"/>
    <dbReference type="OrthoDB" id="3660400at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
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    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="249" mass="27988" checksum="315FBD78774EBB48" modified="2013-05-01" version="1" fragment="single">MHAPVIAWDSREERENERPRVLTYTRKGVNLRAKVLPRVTRDILWTEVNGYAILNVYQNREAPEPAVTYIQELTPPNRCVIGGDMNARHESFEPGSVTTGGGSELARWAQTHAMDFIGQPGVPTHRAGHVIDLTFSNISFADTVVRPDMHSGSDHATQVTTLPTRGLAAEDPKKHRVLERHLERFTKLVGLNIIGIRDPARASNQSQLQTIIQDLTQAIEEAIQTAGVREREQIQVAPWWTTECQTAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7A1</accession>
    <name>M2S7A1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_185947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445659">
        <property type="protein sequence ID" value="EMD58250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706064.1">
        <property type="nucleotide sequence ID" value="XM_007707874.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2S7A1"/>
    <dbReference type="GeneID" id="19133534"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185947"/>
    <dbReference type="eggNOG" id="KOG0319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="OMA" id="DAHSDAC"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="7">
        <location>
            <begin position="299"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="830"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="872"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="914"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="956"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1207"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1249"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1291"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1333"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1476" mass="163784" checksum="1032AA53DCC130D2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7S8</accession>
    <name>M2S7S8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_204393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705889.1">
        <property type="nucleotide sequence ID" value="XM_007707699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7S8"/>
    <dbReference type="STRING" id="665912.M2S7S8"/>
    <dbReference type="GeneID" id="19134291"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_204393"/>
    <dbReference type="eggNOG" id="KOG3354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077168_0_1_1"/>
    <dbReference type="OMA" id="YEGDDYH"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001607">
        <property type="entry name" value="Gluconokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD58440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="231" mass="25469" checksum="E50DD4096BB5FAC4" modified="2013-05-01" version="1">MMQTMEQSVPAPIQYVSPPTPPASNTGSPSTSSPALADTKTAQMTIPAHHHILIVTGPAGCGKSTIAKHLSDRYGFDYIEGDEFHPKANIDKMAAGIPLNDEDRWDWLILLRDQALTALHNGSRGVVVTCSALKKKYRDVIRTARLYDQDPNANVHFVYLRSDMETLLSRVRARQGHYMKDAMVASQFAALEEPDETECKQLKDVEIIDVKGGIQDVQQLASAAVDRILAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2S848</accession>
    <name>M2S848_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_118440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700595.1">
        <property type="nucleotide sequence ID" value="XM_007702405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S848"/>
    <dbReference type="STRING" id="665912.M2S848"/>
    <dbReference type="GeneID" id="19130384"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_118440"/>
    <dbReference type="eggNOG" id="KOG1506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_0_1_1"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="125"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="247"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD63498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="390" mass="42682" checksum="11B0EA0D1E3DADEC" modified="2013-05-01" version="1">MTVPNGSAKGNTFLFTSESVGEGHPDKICDQVSDAILDACLKEDPLSKVACETAAKTGMIMVFGEITTKAHLDYQKIIRNAIKDIGYDSSEKGFDYKTCNVLVAIEQQSPDIAQGLHYEEALEKLGAGDQGIMFGYATDETPELLPLTVLLSHKLNAAMTSARKDGSLPWLRPDTKTQVTIEYAHDGGAVIPLRVDTVVVSAQHSEDITTEKLREEIKEKIIKKVIPANMLDDKTVYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYLARWIAKSLVNAKLARRALVQLSYAIGVSEPLSLFVETYGTSDKSSDELVEIIHKNFDLRPGVIVKELNLIDPIYFQTAKNGHFTNQSFTWEKPKELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2S9P1</accession>
    <name>M2S9P1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_142099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD64038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S9P1"/>
    <dbReference type="GeneID" id="19131231"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_142099"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_1_1"/>
    <dbReference type="OMA" id="ACIPAGY"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD64038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64333.1"/>
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        <property type="nucleotide sequence ID" value="XM_007701965.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19141318"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89822"/>
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    <dbReference type="HOGENOM" id="CLU_023205_10_1_1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AKR"/>
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        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="299" mass="33685" checksum="78356D3E050EB9C6" modified="2013-05-01" version="1">MASVSTTNRISRLYDDKSAFIYGTAWKKDQTKRLVKEALIVGFRRVDTAAQPRHYQEALVGEAIREAFTEGLLKREELYLQTKYTTPAGQDLNNMPYDPSAPLDSQIHTSVASSFKNLHHVSESPNDSYLDCLLLHSPLPTIEQTIQAWKLLETYIPHRIRSLGISNVTLAALQALYQNATIKPAVVQNRFYPQTRYDVPLRNFCKEHDIVYQSFWTLTGNPALLQSQPVVVLARAAQVEIPIALYALVIDQGVVVLNGTTSREHMEMDLEGVQKVRGWAVEKPQEFAAIAEDFKTIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAN0</accession>
    <name>M2SAN0_COCSN</name>
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        <recommendedName>
            <fullName evidence="7">Beta-xylanase</fullName>
            <ecNumber evidence="7">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_40745</name>
    </gene>
    <organism evidence="12 13">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
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        <location>
            <begin position="22"/>
            <end position="58"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB62</accession>
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        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">COCSADRAFT_326413</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
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        <property type="nucleotide sequence ID" value="XM_007702100.1"/>
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    <dbReference type="Proteomes" id="UP000016934">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22489" checksum="9913A216084B69BF" modified="2013-05-01" version="1">MKYCSVTCQQRDAAHHNILCSTFQNFQERPSANHFRSIYFPVDELHPRFIWLRMDGTRGSHYVDNADLSQYVSGNPYGDIFTSSHYGITPEREYKTMIVVQHDQNVFGNGQPVNPCLFYLLGPEAHRWRGAYVGHGYKYTAMADSDDYDDTDAKESDDPLIAVDLDTTSLRPFIAYFLELMRRERVARAFWAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_248464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCA5"/>
    <dbReference type="GeneID" id="19135163"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_248464"/>
    <dbReference type="HOGENOM" id="CLU_1602555_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="166" mass="18124" checksum="43C2944BCBFEB808" modified="2013-05-01" version="1">MHVQTSVAVENPRQPSRQPISSPTQHHASVAAAASGPTCQQQQKGKKHLRGGSSQCASSQPRPAPLRPGHLCSLTCPRTAMDLLLAAKAHTGPEMHLSPFPFPFPCEVRTYGVRNQRHLGTTSMAIPISKLKSILYLNVDCNHACISIYRDIRRDPARQRNVTSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007705649.1"/>
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    <dbReference type="GeneID" id="19132271"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163835"/>
    <dbReference type="eggNOG" id="KOG4840">
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    <dbReference type="OMA" id="PPWVNKE"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR31591:SF7">
        <property type="entry name" value="DUF1749-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34977" checksum="DF7EC17CDC592B4A" modified="2013-05-01" version="1">MAYPGTAHKYSKRRVAFEHSYLNPFADAPNTILWVGGLGDGLLTVPYPSEIAKSLPDNWVIVEVLLGSSYRGWGTSSLSRDARELAECVSYFKQLRPGKKIVVMGHSTGCQDIMEYLVGKGKEKREALDGVILQGGVSDREAWEDFAKEGEKKEALEQAIKHTKELIDAGKGKEILSTEDNVVLKEMGGPLNAYRAHSLLAKGGDDDYFSSDLSDEQFTKTFGRIPRTTPVCFLLGSEDPYIPDSVDREALLERWTKIMRGRGRIVDDVDGGVIPGAHHNLEDDPEHVVEDLVQRVCGFVTGLEESRAWKNVGSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDZ3</accession>
    <name>M2SDZ3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_245508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703974.1">
        <property type="nucleotide sequence ID" value="XM_007705784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SDZ3"/>
    <dbReference type="GeneID" id="19135109"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_245508"/>
    <dbReference type="HOGENOM" id="CLU_181662_0_0_1"/>
    <dbReference type="OMA" id="TLLFRWW"/>
    <dbReference type="OrthoDB" id="10330857at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025522" description="Secreted protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11501" checksum="5D59CF25FCD70F1F" modified="2013-05-01" version="1">MFISRCTGWVVQWAATLLFRWWKRGMFDVCLGKQRRYRSKSRSGRRPASTICGRGAFSFLYVLNQLVSPSAMESSADEDGLKQEKKSRPWSMSWVRVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SE21</accession>
    <name>M2SE21_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenoprotein W-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_180273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698647.1">
        <property type="nucleotide sequence ID" value="XM_007700457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SE21"/>
    <dbReference type="GeneID" id="19133240"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_180273"/>
    <dbReference type="eggNOG" id="ENOG502S6UH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068510_1_2_1"/>
    <dbReference type="OMA" id="KTECEDC"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18589" checksum="1B627933BE37BD16" modified="2013-05-01" version="1">MAGTTHPIPRAMTTIQTAPVALPRVAITYCTQCRWMLRAAYFGQELLSTFGTQIGEIALIPATGGLFTVELTYLPPGEQGQNAEATKVLLWDRKTEGGFPETKVLKQKVRDCIDPSRDLGHSDKHGKKKEEKSVKGDKTEAEEKGAGQEKSQEVEVKRNPDGTVCEDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFA5</accession>
    <name>M2SFA5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_159538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698970.1">
        <property type="nucleotide sequence ID" value="XM_007700780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFA5"/>
    <dbReference type="GeneID" id="19131970"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159538"/>
    <dbReference type="eggNOG" id="ENOG502SRN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1343135_0_0_1"/>
    <dbReference type="OMA" id="RYYRFSW"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22675" checksum="16DD97272DF42431" modified="2013-05-01" version="1">MPVDAPPPMPPPPYFKTDFINPSSFKAAVDSKLDKPSVSLFRLSIRLFQLIFALASGTSYAIELSNGNGRGDASGSFVFSQVTFSATIIALVINGTTVRYYRFSWIVDWVLTVFWLALFATFYKVYLGGAMEPAFEPVNIGRMERAVWCDLVNALLWFGSAVFSSAMCYSGIKGSIQAKLRQRQQRKETKKSMETMSAMETGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFJ0</accession>
    <name>M2SFJ0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_149829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703501.1">
        <property type="nucleotide sequence ID" value="XM_007705311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFJ0"/>
    <dbReference type="STRING" id="665912.M2SFJ0"/>
    <dbReference type="GeneID" id="19131511"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_149829"/>
    <dbReference type="eggNOG" id="KOG0472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007408_0_0_1"/>
    <dbReference type="OMA" id="SWQIKSG"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Condon B.J."/>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697139.1">
        <property type="nucleotide sequence ID" value="XM_007698949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJY6"/>
    <dbReference type="GeneID" id="19140942"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_83212"/>
    <dbReference type="HOGENOM" id="CLU_2639662_0_0_1"/>
    <dbReference type="OMA" id="ETSWTYC"/>
    <dbReference type="OrthoDB" id="3669136at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025723" evidence="1">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="81" mass="8970" checksum="A067BE2330B7DCB7" modified="2013-05-01" version="1">MKIATLVLLWATSAAAWECRNRSEKFRSDKAPVPKRASTETSWTYCPEAAGCCTDGNVWYACKNVSLVPLVCLRSGLLIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKE0</accession>
    <name>M2SKE0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_27283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700936.1">
        <property type="nucleotide sequence ID" value="XM_007702746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKE0"/>
    <dbReference type="STRING" id="665912.M2SKE0"/>
    <dbReference type="GeneID" id="19135652"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_27283"/>
    <dbReference type="eggNOG" id="ENOG502SKCF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="OMA" id="TCRWASH"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF188">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="510" mass="56536" checksum="6E94B4F80C219675" modified="2013-05-01" version="1">MVLPKPNPTKSYWIEAAESPLRDYRSSETLPEETDVAIIGSGYAGVSTAYWLHKYTEHASKQPRVTILEARDVCGAATGRNGGQLRPHLYSRYPLWRDRFGAAGAMHLIRHEHAHLSAFKELCDAEGITEEVCLKLGETFDAAMTDEAWSRLSHALDEVRKDHGDENEIVKICRKIEDQAEVEEVTQMKGALKAIVHPTGQIWPYKFIHALLRILLATPNFTLYSHTPVTTVSERDSTGYITISTARGALRAKTVVHATCRWASHLLPEFERLILPQLGAIAAIKAPPGFLKRTGAQQWDGMNYHVQLPPPYNVIIIGGARQLLCHYPEISILNDEDDKQAPGVPDFYKTWPAAEIVDWPGPKVAELGFDVEKGGSWTGAHETSADGFPFVGALPSRSNQFINAGYTGHVDKRHLSNSQFKGMPRILLSSASLAPLVLDALGLQYSPPQLAASYPALPQPFHATEYRIAKLQDTNPEKVLADYRVQCEASARKPFCNIDRVKGIQSSPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2SM86</accession>
    <name>M2SM86_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10 11">Catalase-peroxidase</fullName>
            <shortName evidence="10">CP</shortName>
            <ecNumber evidence="10 11">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">katG</name>
        <name evidence="13" type="ORF">COCSADRAFT_91618</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10 11">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="10">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="10 11"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700532.1">
        <property type="nucleotide sequence ID" value="XM_007702342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SM86"/>
    <dbReference type="STRING" id="665912.M2SM86"/>
    <dbReference type="GeneID" id="19141411"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_91618"/>
    <dbReference type="eggNOG" id="ENOG502QTDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_1"/>
    <dbReference type="OMA" id="GPETTWL"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 10 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="12">
        <location>
            <begin position="127"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-93)" evidence="10">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD63410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="761" mass="84502" checksum="6D3E7F03AC75AEE0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMC7</accession>
    <name>M2SMC7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_160857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700563.1">
        <property type="nucleotide sequence ID" value="XM_007702373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMC7"/>
    <dbReference type="GeneID" id="19132075"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_160857"/>
    <dbReference type="eggNOG" id="ENOG502QQ27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026719_0_0_1"/>
    <dbReference type="OMA" id="DGPSWMI"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="519" mass="57849" checksum="165DC9903B39A84A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMP5</accession>
    <name>M2SMP5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_33349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695519.1">
        <property type="nucleotide sequence ID" value="XM_007697329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMP5"/>
    <dbReference type="STRING" id="665912.M2SMP5"/>
    <dbReference type="GeneID" id="19137141"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33349"/>
    <dbReference type="eggNOG" id="ENOG502SSI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147541_0_2_1"/>
    <dbReference type="OMA" id="RSKWFGA"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="78" mass="8861" checksum="E7E80F504A08D040" modified="2013-05-01" version="1">MLARATFRAASAPTLVARRGFQSTRAQFSSPYHYPEGPRSNLPFDPLKKGFAFKYWGFMATGFSLPFLLAVWQTKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN34</accession>
    <name>M2SN34_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_144039</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700753.1">
        <property type="nucleotide sequence ID" value="XM_007702563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN34"/>
    <dbReference type="STRING" id="665912.M2SN34"/>
    <dbReference type="GeneID" id="19131299"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_144039"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_3_1"/>
    <dbReference type="OMA" id="FINKPKH"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="32"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="148"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="627"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD63720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="711" mass="78164" checksum="E233AA10AF218DBC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNY1</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_109973</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696388.1">
        <property type="nucleotide sequence ID" value="XM_007698198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNY1"/>
    <dbReference type="GeneID" id="19130110"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_109973"/>
    <dbReference type="eggNOG" id="ENOG502T40G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026012_0_0_1"/>
    <dbReference type="OMA" id="PYYHDSQ"/>
    <dbReference type="OrthoDB" id="3795696at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_36703"/>
    <dbReference type="eggNOG" id="ENOG502S27S">
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        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
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        <property type="entry name" value="Sulf_transp"/>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64125.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="336" mass="35478" checksum="FA0D9591B5C602A3" modified="2013-05-01" version="1">MFTPVETTVGALLLHQATSNLLYQNGNILGLSGYLRQLLSAPTKEQIAFFTGMAASYVPLKALAPQLMAVYPMVQLSPKTAMATSAVGALIGWGTKMANGCTSGHMLCGLSRLSGRSATAVAVFFPTAMITHHLTNPTLSTSVCASDVPCYTPVYPSSEEAVSLLVLAGSITMAAQTIPHLVALATSSDGTKQEAGEPPNAARNTTQFFSGLLFALGLQVSQMAQPAKVAAFLSFPVLQHWDPSLALVMIFGVLPNLIENQIKGFKKPPSFAERFALPTKTAQDIDKRFVMGAVAFGIGWGLAGVCPGPAVIRAFYQPIWGLLWIGGFWLGGKVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPH0</accession>
    <name>M2SPH0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside 2-deoxyribosyltransferase like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_31856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694129.1">
        <property type="nucleotide sequence ID" value="XM_007695939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPH0"/>
    <dbReference type="GeneID" id="19136554"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31856"/>
    <dbReference type="HOGENOM" id="CLU_109866_0_0_1"/>
    <dbReference type="OMA" id="YREQVEW"/>
    <dbReference type="OrthoDB" id="2893324at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039470">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15891">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18812" checksum="D595EF71ADDC1BDE" modified="2013-05-01" version="1">MSQPAPTKAVVHKPPLRKDVDRPSVILYGAIQSDPAKDWQGYLTASLSDLPVAILNPRCDAWDSSWVEDISFPPFKEQVEWEMDHARIADIIVFYFAGEPKVLQPITLLELGLYADTGKAVVYCPKGFWKRGNVQIVCQRYNIEMCETLEELGENVRARLMAKLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR53</accession>
    <name>M2SR53_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_347799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705019.1">
        <property type="nucleotide sequence ID" value="XM_007706829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR53"/>
    <dbReference type="GeneID" id="19137860"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_347799"/>
    <dbReference type="HOGENOM" id="CLU_104691_0_0_1"/>
    <dbReference type="OrthoDB" id="10313956at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="286" mass="31427" checksum="2F81510FE4986D77" modified="2013-05-01" version="1">MARTRSKMRQGRALAVDSLFWNREVSRERRVAYTVVDETKWANTIAPLPEQLPDRDGTHVECWHTQLHIECLVAAKPIQTTETPNAVPPQTQMGLPLAVESRLSAAASCRRQKPNEARSKVGRRSVFTSFPPSFGAQGPEMLLIFRPKRGADTTLPAPPLFQQAAIRAKSTSPVDATHCFSRSSRLIPRLASPQLTGALEGAHVLFLGWNGNSCLSHTSSFGLVFVCVAFRIFLESNGTHSQSGQSLHNVHCGHMVRAFSRASHSQSAPIFMKSSSLSVLSMLRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRH2</accession>
    <name>M2SRH2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_22033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694084.1">
        <property type="nucleotide sequence ID" value="XM_007695894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRH2"/>
    <dbReference type="STRING" id="665912.M2SRH2"/>
    <dbReference type="GeneID" id="19134575"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_22033"/>
    <dbReference type="eggNOG" id="KOG1049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039307_0_0_1"/>
    <dbReference type="OMA" id="FDEFTWE"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="325" mass="33421" checksum="2E3E6F8BE421B87F" modified="2013-05-01" version="1">MADESDDDLYGDESATQQNKDADKAEDNSSGDEPMDEESGDDDDDDDDSDSDIDIIIEKAPAPAKPAASQQPQESKAIKIEAPPPSTTPSQQPPPKTGPATGGTIPQISVSALSGTAFPAQRTSTIDVNGNPVYPPQGKEILSVDIDADLAEEHKIWRRPGEDQSDYFNYGFDEFTWELYRQRQVAMANTIQGQKNDMAQMQAMMGGGPMPGMPGMGGAPQGNGGPGGAPPSGPGGGGGGGGGAGGGGAMGPGGMNEQQMQMMMQEMMAQGMDPSQMDFASFMQMAGQGMGGFPTGPGGQQGAGFQQGHQGGGGRGGRGARGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRN1</accession>
    <name>M2SRN1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_175986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705165.1">
        <property type="nucleotide sequence ID" value="XM_007706975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRN1"/>
    <dbReference type="STRING" id="665912.M2SRN1"/>
    <dbReference type="GeneID" id="19133004"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175986"/>
    <dbReference type="eggNOG" id="ENOG502SNK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224572_0_0_1"/>
    <dbReference type="OMA" id="LAADWFV"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026064" description="Concanavalin A-like lectin/glucanase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="23517" checksum="CED9E62185EF9B89" modified="2013-05-01" version="1">MKLISLLSATCWLSFVSAAFDYNRGGAVLKAPDGDSFQTVTSTFTVPNLSGSNRLSIWVGIGDGLEQNNILSGGIVYNSTLKTFASYFPGPATDTTSAVPVANGDSITITVNITLTGGTVTIENNMQNKRTTQIVAAPAGVEPTSLTALAADWFVQAYQVIPGELVATPDFGTVSFTSIKATTKGGVDVPVSGAGRYEIQGTSGQMYSRTTISDAGISVQRQTVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRS6</accession>
    <name>M2SRS6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_32586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694331.1">
        <property type="nucleotide sequence ID" value="XM_007696141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRS6"/>
    <dbReference type="GeneID" id="19136834"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32586"/>
    <dbReference type="eggNOG" id="ENOG502RZMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_3_0_1"/>
    <dbReference type="OMA" id="IPIEHRY"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34218" checksum="888E073E509716C2" modified="2013-05-01" version="1">MTTAASRPTPAHQLSNPAPTSSDAASRDVNFQGLPIPRGPVKAQLSFYKAPEDCAPPYNYVEPPPGVPQRNWGDNWAEVTIEDLRGKEQNFTLDNNAFDTFQNIQSGLTREDFEDDEAIKRVYYHEVEDLLLNNVQGAQRVLIFDHTIRRPSGNRNPVQRVHIDQTPLSAAERVKLHAPEDAEKLLQGRYRIINVWRPLNGPVMGSPLAVADSQTVRDGDLIPIEHRYPHRNGQTAAVAYNPDQKWYYWSGMKNEDRLLLKCFDSDEVVGQWGRVPHTAFVDPRTPEGAMGRESIEIRALIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRX3</accession>
    <name>M2SRX3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD superfamily phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_116325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699542.1">
        <property type="nucleotide sequence ID" value="XM_007701352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRX3"/>
    <dbReference type="STRING" id="665912.M2SRX3"/>
    <dbReference type="GeneID" id="19130323"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116325"/>
    <dbReference type="eggNOG" id="KOG2961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056221_3_2_1"/>
    <dbReference type="OMA" id="MLMANMM"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000165">
        <property type="entry name" value="HAD superfamily phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23556" checksum="B4E1C309EE7039BF" modified="2013-05-01" version="1">MNISGTLNIFRLLRDPTLCLPQHTIPTFNQLPVPLSKAFPRKQGEKEVDIRAVILDKDNCFAVPHTDEIYEPYQDHFTRLRAAYPGRKLLIVSNTAGTSSDPHGTQATLLERNTGVVVLRHSTKKPGCKDDVMAYFAAHPETGVTRPEHVAVVGDRLSTDVMMANLMGGYGVWVRDGVQGRGFFARMEDRLQSLLFGRGYCAPDPSRNQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSC5</accession>
    <name>M2SSC5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_116684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699650.1">
        <property type="nucleotide sequence ID" value="XM_007701460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSC5"/>
    <dbReference type="STRING" id="665912.M2SSC5"/>
    <dbReference type="GeneID" id="19130334"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116684"/>
    <dbReference type="eggNOG" id="ENOG502S1Y5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055310_2_1_1"/>
    <dbReference type="OMA" id="CADYEDQ"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="154"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="158"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="261" mass="29161" checksum="284761E934009350" modified="2013-05-01" version="1">MAATLEVSPPASPQPAKDTANDTQTHNCPSCGYSLNTKELEEARRKIEELEAQMERLKEKATAAVDRCADYEDQIRVLKDSQRAPSPLRSQTSQSDKTFNGALPRPSVDADPPRPTTANSTRASRFSFITNRFPSPANTGAMPPPPPPKDDYALINELERERALRAKAEARVQTVDTEIEELSVQLFSQANEMVAEERRARAKLEERIETLERRDREKMGRLDRLEKAVSRVERVKALLAEKDGKGVEAPPDGMLSLPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSD4</accession>
    <name>M2SSD4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_76068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695245.1">
        <property type="nucleotide sequence ID" value="XM_007697055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSD4"/>
    <dbReference type="GeneID" id="19140544"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_76068"/>
    <dbReference type="eggNOG" id="ENOG502SPK2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526868_0_0_1"/>
    <dbReference type="OMA" id="SHLYYYL"/>
    <dbReference type="OrthoDB" id="2522477at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD70113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="553" mass="62721" checksum="44E916D8C245D086" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSH9</accession>
    <name>M2SSH9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_36564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="44"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="76"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="40"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD70228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="400" mass="44348" checksum="CAF9E0D270119C58" modified="2013-05-01" version="1">MPSTSVGPPVDPKWAAENNLPRLLALTGIFHIAALTSVCLRIFVRVGLLRSLGKDDIAIVLAALGALGGWICFILQGNHGFGRHTMTVSKEDMQEFTHIGFFGSIISAIGALGLLKISIALFLLRLKNNNIWKWYSRCLWALIALVTIYTIGAWLSFFLYCKPMEAMWTKKGVCYSQKMFVAFALTNTALNIFTDVCFATLPIPIIWSLQMSRTTRINLIGVLSLGYIAVALGIVKASYQVKRDPDRTFNQHLNVFGFLQLNVGIIAACIPTLKPLLRSTPSSRTPRRSNYNDIEHAETIGSGRQHKPRASFLNTTKTSPTTTNTLTIDETFEMANRGSLREKLAGGPNHQNVVYSDRNGVHTSSQERILHAEGGAEDASKILRTTEVVIDSVERVRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2STK0</accession>
    <name>M2STK0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAD superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703603.1">
        <property type="nucleotide sequence ID" value="XM_007705413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STK0"/>
    <dbReference type="STRING" id="665912.M2STK0"/>
    <dbReference type="GeneID" id="19139636"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40068"/>
    <dbReference type="eggNOG" id="ENOG502QR7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_11_1_1"/>
    <dbReference type="OMA" id="QTYMFKE"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25345" checksum="6914937AE184E418" modified="2013-05-01" version="1">MAQRPRRFAPLDPAKRKEGDQRPELKGIVFDVDGTLCLPQNYMFAEMRATLGIEKPTDILDHVYSLPESEQEEAQEKIRNIERTAMKSQQPQAGLVELMEYLDSRGVKKGICTRNFDAPVAHLLTTFLPQSKFSPIVTREFRPPKPDPAGILHIAKDWMHEDGGNSLIMVGDSIDDMTAGHRAGAATVLLVNDVNNHLAEHEHTDLVVKRLDDLIAILENGFEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2STT2</accession>
    <name>M2STT2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_40621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704137.1">
        <property type="nucleotide sequence ID" value="XM_007705947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STT2"/>
    <dbReference type="STRING" id="665912.M2STT2"/>
    <dbReference type="GeneID" id="19139792"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40621"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="OMA" id="CINCDQT"/>
    <dbReference type="OrthoDB" id="3690466at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="282" mass="31245" checksum="C5104009C3776D61" modified="2013-05-01" version="1">MVSTFPSIKVGLMVGIGGGIPPMVRLGDVVVSAPVDQYPGVVQWDIGKAEKDGNFKRTGALNNPPNALLTALTKLETKHDICGSKIPQYLDDLGKNWPNLVPKYTRSDSLQDPFFTLDGSQRAQGKWQAIFSLLWVKMLFLLGYFLGQWVLVPLDSGADQATSRVANVKIDRTQRKSRDMRVHYGLIASGNQVIKDHEFRDNLNRSLGGHVLCVEMEAAGLMNDFPCIVIRGICDYADSQKNKDWQEHAAAVAAAYAKELLEHVQPSDIDRERPVKDILDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2STV4</accession>
    <name>M2STV4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_346777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Wu D."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Wu D."/>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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        </recommendedName>
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    </gene>
    <organism evidence="3 4">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="703" mass="78840" checksum="0A3A17EAC8429EA1" modified="2013-05-01" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        </source>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24148:SF80">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
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        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="555"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123665" checksum="981C979D3EC73F53" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SV17</accession>
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            <fullName evidence="2">A to I editase domain-containing protein</fullName>
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    </protein>
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    <organism evidence="3 4">
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </evidence>
    <sequence length="88" mass="9549" checksum="8D896CEA359ABB31" modified="2013-05-01" version="1">MTTSTNPTSMQASPSPPPPPHRYDRQIQSPPSNDTSHPPKLPANAVPHPSRSGRLAPERERAGLTKQYLAPTIAASRAPDRCRQSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX25</accession>
    <name>M2SX25_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_230788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702748.1">
        <property type="nucleotide sequence ID" value="XM_007704558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX25"/>
    <dbReference type="STRING" id="665912.M2SX25"/>
    <dbReference type="GeneID" id="19134772"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_230788"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_3_2_1"/>
    <dbReference type="OMA" id="DADFGRC"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="255" mass="29713" checksum="31CD5C8A1787A24F" modified="2013-05-01" version="1">MDDFNSETDSDYTSYWRDWFISSRGNEYFCEIDEEYLTDRFNLTGLNTEVQYYQYALDLVTDVFDFDCDDDMREQIEKSARHLYGLVHARYIVTTRGLAKMLEKFKKSDFGKCPRVMCESQPLLPMGQSDVPNASPVKLYCARCEDLYNPKSSRHAIIDGAYFGTSFHNILFQVYPAMLPPKTQRRYEPRVFGFKVHSAAALARWQSDKKEEMKDRLKALKMETGFEEEDEELEDDDDDDDMELQEGVQGAAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX82</accession>
    <name>M2SX82_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_123089</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702785.1">
        <property type="nucleotide sequence ID" value="XM_007704595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX82"/>
    <dbReference type="STRING" id="665912.M2SX82"/>
    <dbReference type="GeneID" id="19130545"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_123089"/>
    <dbReference type="eggNOG" id="KOG2863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005893_1_0_1"/>
    <dbReference type="OMA" id="GIDDPLC"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="351"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="503"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD61437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="558" mass="62492" checksum="593009692A08C1E0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYB9</accession>
    <name>M2SYB9_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">SNF7 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_38743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYB9"/>
    <dbReference type="GeneID" id="19139331"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38743"/>
    <dbReference type="HOGENOM" id="CLU_1618865_0_0_1"/>
    <dbReference type="OrthoDB" id="10540536at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18551" checksum="80C5E8B6333A957F" modified="2013-05-01" version="1">MLDEATTKRDRLASQLHEAKANMTKLRRSDRTKEKTQQQNIHLKALLHRQSVKYNTTKYSTAATFRGVTAALNQNILQSALSAAIERIDELEARGQALLDALLDALEEQGTSSEEEEGEGEGEEEYDDSEAVAKLLKAQVKLDGVLRDKGFTLERRTWRHLLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYX8</accession>
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        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_343799</name>
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    <organism evidence="8 9">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702440.1">
        <property type="nucleotide sequence ID" value="XM_007704250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYX8"/>
    <dbReference type="STRING" id="665912.M2SYX8"/>
    <dbReference type="GeneID" id="19137620"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_343799"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018012_3_0_1"/>
    <dbReference type="OMA" id="FVFRSVM"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD62136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="60735" checksum="7FCCFEB68E146DE1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZI3</accession>
    <name>M2SZI3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_111773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697304.1">
        <property type="nucleotide sequence ID" value="XM_007699114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZI3"/>
    <dbReference type="STRING" id="665912.M2SZI3"/>
    <dbReference type="GeneID" id="19130162"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_111773"/>
    <dbReference type="eggNOG" id="KOG2924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_0_0_1"/>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD67720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="357" mass="38885" checksum="759A60783EDCF400" modified="2013-05-01" version="1">MASTSSAPAGATDAVLKPSEPVPEGVQQVQGIDFNQHAARPITVDELVGGYATMGFQATSVGAAVRIINDMRAWRDPETGDRTTIFLGYTSNLISSGLRETLRYLVQHKHVSAIVTTAGGVEEDFIKCLAPTYLGSFSTPGAGLRKKGMNRIGNLVVPNSNYCAFEDWVVPILDKMLEEQEASKKTDEPLHWTPSKVIHRLGKEINDERSVYYWAWKNDIPVFCPALTDGSLGDMLYFHTFKSSPEQLRVDIVEDIRKINTIAVRAKRTGMIVLGGGLVKHHIANANLMRNGAESAVYINTAQEFDGSDAGARPDEAVSWGKIKLDGDSVKVYAEATVVFPLIVAATFARVTAKAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZL7</accession>
    <name>M2SZL7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_122662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702500.1">
        <property type="nucleotide sequence ID" value="XM_007704310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZL7"/>
    <dbReference type="STRING" id="665912.M2SZL7"/>
    <dbReference type="GeneID" id="19130530"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_122662"/>
    <dbReference type="eggNOG" id="ENOG502S0MF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_0_0_1"/>
    <dbReference type="OMA" id="SWNARPY"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025495" description="Isochorismatase-like domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="5">
        <location>
            <begin position="85"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="301" mass="33188" checksum="F891C63013F7206D" modified="2013-05-01" version="1">MKLPAVMVSTMAALPLVSSTIITAYQNITLPTTNTTLLGNIYNHWIYLGNDTYDLTRSMVAPTTKPVTIPMTGSRKRAVIEPSRSALVIIDMQNFFLHPELTPSAEGGRKAVEPTLNMIDAFRRNGMPVLWTNWGLDGKDLRDLPPADISGFSQTKRSPTNSFGSDMGKLKDGTELGRTLMRGSWNARPYGKLYDAQVQGVKDGTDHYFNKNRVSGMWGAQTPLGLWLEENQITTLFFGGVNSDQCVYGTLLDAYFKGYDTVFVDDISATISPEYAAQMVRYNSDLNGFVSNSSLIIPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2T027</accession>
    <name>M2T027_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_266776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="424" mass="45223" checksum="995B859262B43E35" modified="2013-05-01" version="1">MGLFGKKKDKGAEAEDSNRSALFGSRKGKESPAAQNPYAAPPANDPYAQPPPSYSGGQDSSFRQEKTPAVTGPGQAYGQRPGGYGAQGGSYGAQSGYGNDQYGGGPPQRPGGYGGLGRTASNDTMATDAGRNELFGNAPQRQQGRPQQESGGYGQSGAYGDSQSGGYGGGGAAAGGYGSTPGGYGTYEDRQLTAEEQEEEDINATKQEIKFIKQQDVSSTRNALRLAEQALETGRGTLSTMAAQGERIHNTERNLDLASIQSDRASGQTKELARINASMFSVVPNPFTGNSKREKEMQRAMDQHTRDRETREATNKAAWESAARANQVQRGIQGGGAGIGGNKASLAQRSKYQMEPDSEDDEMENEIENNLDQLHTAAKSLNQLGRAMGTEADKQNEHITRITGKTDNVDDKIARNRLKLDRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1P7</accession>
    <name>M2T1P7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_63307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701356.1">
        <property type="nucleotide sequence ID" value="XM_007703166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1P7"/>
    <dbReference type="GeneID" id="19140407"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_63307"/>
    <dbReference type="HOGENOM" id="CLU_114647_0_0_1"/>
    <dbReference type="OMA" id="RNCNYDC"/>
    <dbReference type="OrthoDB" id="3761807at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="199" mass="21195" checksum="0724216695A1C18C" modified="2013-05-01" version="1" fragment="single">MYNHNDGNDSPMQPNISTFSPKRPPQFRNCNYDCGLGCKKDSDDEGGGADDDQTVVGEEENLYSDAEAQDESGGESEDLSGSEESMPDSGASASDGTGGEFSSSLESGDMSASMVVEPTSSGDRSPVIRASIPARSLSPNPGNTIPLIGLIPVPSPLPMRYYFLQTPLRLSPQVEDCRGDPASLPVVPDRIRLSFLMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2D3</accession>
    <name>M2T2D3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_338429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701400.1">
        <property type="nucleotide sequence ID" value="XM_007703210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2D3"/>
    <dbReference type="GeneID" id="19137333"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_338429"/>
    <dbReference type="HOGENOM" id="CLU_1366128_0_0_1"/>
    <dbReference type="OMA" id="HATKNRQ"/>
    <dbReference type="OrthoDB" id="3693161at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="204" mass="21895" checksum="36C065B643DAEC8E" modified="2013-05-01" version="1">MGNKGEPTALDSRSPKGNSSIRRLLHFLKHATKNRQTDTYSLKSKASDLPSVPSTPQSSSTEGKTMSTRFNADEFRMRAQLSNTSSTVPPNSNLVAASESTRQALSSVPENAASKNGPQASSQTSVAPSSADTPSASKSQKSRKSHKPTMITPELMQQIQISNKKRSGGALRDNGELRRKNLGTATVTNRAKAVVASPLRWSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2L0</accession>
    <name>M2T2L0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_328020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700557.1">
        <property type="nucleotide sequence ID" value="XM_007702367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2L0"/>
    <dbReference type="STRING" id="665912.M2T2L0"/>
    <dbReference type="GeneID" id="19136905"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_328020"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="OMA" id="ADCVQQF"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="219"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD63441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="491" mass="54235" checksum="FB6A19AFE4603B9F" modified="2013-05-01" version="1">MTIVLGSMADMPRDLKEQIEKLEEHFVVSTEKLKHISDHFVKELEKGLSEQGGSIPMIPTWCMAFPDGNETGKYLALDMGGTNLRVCEVTLTEEKGEFEIIQSKYRMPEELKTGTADELWGYVADCLQQFIEYHHEGEQLADLPLGFTFSYPVSQDAIDHGVLQRWTKGFDVQGMEGVDVVPGFKAALEERGVPIKLAALVNDTTGTMIASAYTDTSIKIGCIFGTGCNAAYMEECGAIPKLKHMNLDPKLPMAINCEWGAFDNEHQVLPRTKYDVIIDKESPRPGQQTFEKMVAGLYLGEIFRLVLLDLHKGSECSMFEGQNASKLDKPYSLDAGFLSQIEEDRFENLQDTADLFQETLGITCTKPELELIRRLAELIGTRAARLTACGVSAICKHKKWSEVHVGADGSVFSKYPHFKIRQAQALKEIMDWPAKYGKGKNDPIEVLPAEDGSGVGAALIAALTVKRAQQGQLAGISDQDALLAMGKTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2L6</accession>
    <name>M2T2L6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_160854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700560.1">
        <property type="nucleotide sequence ID" value="XM_007702370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2L6"/>
    <dbReference type="STRING" id="665912.M2T2L6"/>
    <dbReference type="GeneID" id="19132074"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_160854"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_0_0_1"/>
    <dbReference type="OMA" id="AMPNMMN"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000466">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein HRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031">
        <property type="entry name" value="SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="191"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD63446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="569" mass="60265" checksum="A9E7F5B21F16B1E1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4B6</accession>
    <name>M2T4B6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_332383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <sequence length="201" mass="22419" checksum="54B86FA0AF914CB3" modified="2013-05-01" version="1">MVSSSSEQSQMRFLAIVLPVLTFCAHGLLVMSFGLPGSDLDGAYFPITYNLLACGASILGFVGALRALPSLVSAYTLLHTMTLSFLTIAIVNLILPWDFRTLNPVTPSYTVDESAICRDIDAGFGWDTEWLEQCTKSLSTIKFWCTGFSMVLIFVQWWALMSVRTWGQEQRARSQDTRRDVEKAGLGTDEKMTIYDQKTGF</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="80" mass="8781" checksum="C8B6DFC250F8EB84" modified="2013-05-01" version="1">MALRTNFPLVLFLLSSFLPKIVCKTTKDVVKVTLFLLTLDSGISHVPHQSSRPCIGSSSAIQRTVSPGYKTASLYRKMAL</sequence>
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    <accession>M2T619</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
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    <dbReference type="OrthoDB" id="413008at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
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    </dbReference>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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        <location>
            <begin position="34"/>
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        <location>
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        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD64517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="916" mass="100787" checksum="DF034F5212CDD859" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T783</accession>
    <name>M2T783_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_36213</name>
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    <organism evidence="13 14">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
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        <property type="protein sequence ID" value="EMD64837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007700932.1"/>
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    <dbReference type="eggNOG" id="KOG2031">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:exonuclease activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF06087">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="26"/>
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            <position position="206"/>
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        <location>
            <position position="481"/>
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        <location>
            <position position="208"/>
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        <ligand>
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        <location>
            <position position="483"/>
        </location>
        <ligand>
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            <position position="507"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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</entry>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="665912.M2T7C5"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_36457"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_030988_13_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Ub_conjugating_enzyme"/>
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        <property type="entry name" value="UBC"/>
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        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="164" mass="18385" checksum="4CE7BEAE05E1A25C" modified="2013-05-01" version="1">MAGSSRNASPIKRLMTELQTYQSNKNDVLYDLGPTDDDVMQWRAVMKGVPGTAYEDGCWLLSISIPSTYPLAPPTIRFITPICHPNVDFKTGEICLDLLKTSWTPAYTISTTMTSIHQLLTSAEPDSPLNVDVAQLFRTGDEVGARSLIRWYTASEKYAWKDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7K2</accession>
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        <recommendedName>
            <fullName evidence="9">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_116142</name>
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    <organism evidence="10 11">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699470.1">
        <property type="nucleotide sequence ID" value="XM_007701280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7K2"/>
    <dbReference type="STRING" id="665912.M2T7K2"/>
    <dbReference type="GeneID" id="19130312"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116142"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_3_1_1"/>
    <dbReference type="OMA" id="RPQFKPY"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00443">
        <property type="entry name" value="ADA_AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD64937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="352" mass="39455" checksum="18D9AFBBBED48807" modified="2013-05-01" version="1">MSVPALPVHAAFAKRLPKIELHAHLTGSISRECLHDIWTASKAQRQDIDVQDPLIAIPPGKVDYDIKTFFPLFSSYIYRLCSDLPSIEYSTKHVLRAFQEDGIVYTELRTTPRAIPEQNVSREDYVKTVLDVLKAHNADSTNTMRAFLILSIDRRNTIAEAEQVVSLAIKYQSAGVVGIDLCGDPTKGDVRIFGDSFARAKAAGLKLTLHFAEVETSASDTELQTLLSWKPDRLGHVIHVKDEFQKMIQQDNIGVELCLSCNVQAKMITGTYSDHHFGTWRRSTVPVALSTDDVGVFCSPLSQEYCLAAQHFQLDRHEIRALCERAIDSIFAGPEEHARLKQIYATWDGWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T884</accession>
    <name>M2T884_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_305878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698599.1">
        <property type="nucleotide sequence ID" value="XM_007700409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T884"/>
    <dbReference type="GeneID" id="19136273"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_305878"/>
    <dbReference type="eggNOG" id="ENOG502RKFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059603_2_0_1"/>
    <dbReference type="OMA" id="PLNKFYW"/>
    <dbReference type="OrthoDB" id="5419460at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="251" mass="27427" checksum="467114FA8FB636E8" modified="2013-05-01" version="1">MAGPARPLLAIASLVLVAAGLLFQFLTILTGGVNKSPLDRFYFLEASTNGIPNARNPSRWTFFAICGENPSNGRNANCGSPVPALPFDPPRNFGTEQNIPDAFLGTKQYFYLSRFMFAFYLIALFFAAVALLSGLLALFSRLGGYLSSLMTSIALFFQALAAALMTAWVVKGRDGFRSAGFQARIGRYLMGFTWAAVACFFLATIMFCLGGRLGGDSSSRMRRNRSTKSTRSRGSFLDTDSQRRVKSDYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8S9</accession>
    <name>M2T8S9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_114688</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698738.1">
        <property type="nucleotide sequence ID" value="XM_007700548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8S9"/>
    <dbReference type="STRING" id="665912.M2T8S9"/>
    <dbReference type="GeneID" id="19130256"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_114688"/>
    <dbReference type="eggNOG" id="KOG3893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024220_1_0_1"/>
    <dbReference type="OMA" id="MLWFIGQ"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD65656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="434" mass="49612" checksum="945EE877393ABBC2" modified="2013-05-01" version="1">MALSSFFRSPVLVFTASVVLRAVFLIYGLWQDANSPMKYTDIDYYVFTDAARYISRGQPPYARDTYRYTPLLAWLIYPTVWSGKFWFSFGKILFAVGDVATGWMMFRILKEYKKMGDERALKFASIWLLNPMVATISTRGSSEGLLGVFVTALLWAVLAKNVPLAGFLLGFTVHFKIYPFIYAVSIVWFLDETQFQSTKSAASQSSRSLFGQIQAFITLPRLSLAFYSLFTFTVLNLAMYQMYGWPFLEHSYLYHLIRSDHRHNFSPYNTLLYLNSSPNQLGLESGSASFELERLAFLPQLLLSAVFIPLALAKKDLPNTMLAQTFAFVTFNKVCTSQYFLWYMMFLPYYLPQSTLLQSAPIGIAAIVAWIAGQAVWLQQGFQLEFNGHSTFLPRLWLSSILFFLVNAIILSIIIYDTKQKPTQSDIVQGKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8X0</accession>
    <name>M2T8X0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_189451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698770.1">
        <property type="nucleotide sequence ID" value="XM_007700580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8X0"/>
    <dbReference type="STRING" id="665912.M2T8X0"/>
    <dbReference type="GeneID" id="19133674"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_189451"/>
    <dbReference type="eggNOG" id="KOG3234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000058">
        <property type="entry name" value="N-acetyltransferase (Nat5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="193" mass="21995" checksum="CED3A7CA2DF91944" modified="2013-05-01" version="1">MSTIRPMRPDDLLRISSTNLDHLTETYNIGFYLEYLTRWPELCQIIEGMDGQIEGYILGKLESSPFAPPISPYKPSTTGVEYPNYLPWHGHITALTVAPSARRLGHATALSSALERSSDAADAWFVDLFVRASNEIAKELYRKMGYSVYRVVKAYYNDGEDALDMRKSCSRDKNRECVRADGEKWEVEADDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2TA20</accession>
    <name>M2TA20_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_170235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG3498">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167752_2_0_1"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
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        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SECE_SEC61G"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD65767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7669" checksum="C8CC7F835F2800F7" modified="2013-05-01" version="1">MENIKEFADMPAEFLKEGTLFMNRCTKPDKKEFIRISQAVGIGFLIMGVIGYVVKLVHIPVNNILVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAJ2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_34789</name>
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    <organism evidence="1 2">
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        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="80" mass="8823" checksum="4B7A195E50A183E2" modified="2013-05-01" version="1">MFQRYREVSRVTAEGERHSGAGVLKLAHAEAAPRSSDIVEASGAGGMRWQHGCSQKGREADSQQDVFLLCFVLFGAWVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2TG54</accession>
    <name>M2TG54_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_156678</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68226.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RM27">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="92" mass="9537" checksum="9320E99CAF033D62" modified="2013-05-01" version="1">MSTMESTIRPTGYGSDSESDGQASGGRKVSANVGPVPSSATLNRPAGNIIKGPVDDNGKQKDAALLIGIKLDLEAEIHLTARIRGDITIGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGJ0</accession>
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        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_134014</name>
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    <organism evidence="10 11">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695987.1">
        <property type="nucleotide sequence ID" value="XM_007697797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGJ0"/>
    <dbReference type="STRING" id="665912.M2TGJ0"/>
    <dbReference type="GeneID" id="19130912"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134014"/>
    <dbReference type="eggNOG" id="KOG2366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013093_3_0_1"/>
    <dbReference type="OMA" id="APHDCKI"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025968" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="330"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD68361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="551" mass="58306" checksum="5691A1900BE38550" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGL9</accession>
    <name>M2TGL9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_134068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696010.1">
        <property type="nucleotide sequence ID" value="XM_007697820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGL9"/>
    <dbReference type="STRING" id="665912.M2TGL9"/>
    <dbReference type="GeneID" id="19130915"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134068"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_1_1"/>
    <dbReference type="OMA" id="ELWRIGC"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="437" mass="48579" checksum="8374BD702070DE56" modified="2013-05-01" version="1">MTPAKTRPTVLIVGGGLAGLFCALECKRNGFETTVLESRPAIQTAGDFITIGPTAINALRRWPSIAIALDKVAYKPDIWYHKQDGELVAGPMPPHPNFGRMISRPALHQALWHALEAENVDIRCKTKVKRYWETEDEGGVELENGDMLRADMVIAADGIHTKSWTLVSGKEPEIYPSGLAMFRAAFPIEHALADPSLRAKWTPTAEKDKMGFFLSPTSFGIILFGQNTASWVWQHNENPETSTESWAATLSPEDALKQLDAEGHWGADLRAIIATTPQNHIVDWRLMRRELKRKWGSPKGRLMQIGDAAHPYLPTTVNGGTQAIEDGVSLARCLRLAIDKHGASALPAGAKVHNSLRIDRVAAIETTGMERTKKHRQVDFEQVKKNPELIRNEPAQWQIEHDPLAYAEERFDECFACLTNGKPFVNTNKPEGYVFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TH45</accession>
    <name>M2TH45_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_134400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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        <property type="protein sequence ID" value="EMD68546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19130927"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134400"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_2_1"/>
    <dbReference type="OMA" id="WRWNFWF"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="115"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD68546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="550" mass="60746" checksum="6731EF184D400B82" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2THT7</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_78911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695929.1">
        <property type="nucleotide sequence ID" value="XM_007697739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THT7"/>
    <dbReference type="GeneID" id="19140693"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_78911"/>
    <dbReference type="eggNOG" id="ENOG502SRYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017396_0_0_1"/>
    <dbReference type="OMA" id="IHEDETW"/>
    <dbReference type="OrthoDB" id="5355526at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="614" mass="68813" checksum="09B83C2047663D3F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJS8</accession>
    <name>M2TJS8_COCSN</name>
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        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_194858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694427.1">
        <property type="nucleotide sequence ID" value="XM_007696237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJS8"/>
    <dbReference type="SMR" id="M2TJS8"/>
    <dbReference type="GeneID" id="19133910"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_194858"/>
    <dbReference type="eggNOG" id="ENOG502QV0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_1_0_1"/>
    <dbReference type="OMA" id="WRGAVYN"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="537" mass="57692" checksum="68893D08F5941D91" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK00</accession>
    <name>M2TK00_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_210659</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694809.1">
        <property type="nucleotide sequence ID" value="XM_007696619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TK00"/>
    <dbReference type="MEROPS" id="M36.001"/>
    <dbReference type="GeneID" id="19134393"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_210659"/>
    <dbReference type="eggNOG" id="ENOG502QTDC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012703_3_0_1"/>
    <dbReference type="OMA" id="YIWTRAN"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009368139" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="86"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD69501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="641" mass="69803" checksum="53CB3820AB84A4F7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKN3</accession>
    <name>M2TKN3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_213051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694961.1">
        <property type="nucleotide sequence ID" value="XM_007696771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKN3"/>
    <dbReference type="GeneID" id="19134439"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_213051"/>
    <dbReference type="eggNOG" id="ENOG502S338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066710_1_0_1"/>
    <dbReference type="OMA" id="DTHLGPQ"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF238">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22648" checksum="FF971CF4E2311615" modified="2013-05-01" version="1">MSSPPSTKRSLKPSPMTTNLPPTARPAAPADLPTLHPAAPLTAPAQDTHLGPQQPLPSPTSRKRKSVTLGHSHEPMAGATESSVETHATSAALPPPPQPDVVQEPKAKKSRTNTPWTPAEELRLKQMRDAGNSWSEIAKTFPQRTEGSVKKHWYKDMHYAEFAEDESAALLAAIKEYDANKWKVIGQKVGKPAKACEQYAKENFGGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLL7</accession>
    <name>M2TLL7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 24">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 26">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">COCSADRAFT_132520</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="33" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695189.1">
        <property type="nucleotide sequence ID" value="XM_007696999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLL7"/>
    <dbReference type="STRING" id="665912.M2TLL7"/>
    <dbReference type="GeneID" id="19130852"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_132520"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011815_2_0_1"/>
    <dbReference type="OMA" id="QYQRHGY"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="28" id="KW-0862">Zinc</keyword>
    <keyword evidence="28" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="31">
        <location>
            <begin position="215"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="79"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="27">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="EMD70046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="503" mass="57704" checksum="C2246C49B9176130" modified="2013-05-01" version="1">MAPRENSHEPSGTPAPVETGFATLAQLRVGVKAWVEKDGEKRKAEILSIQTRQGRPKFYVHYEEFNKRLDEWIEAERIDLSREVEWPAPEKADKKKGTASKNEKAPSKSDQKNLKRSRSKLDREISGTPESTSSNLPGKAPRPSKAGGKENQEVLVTSEVTDGTPKAEDEEMDLVDVQDAAAAAKAMPPQDFSREDEIEKLRTSGSMTQNQTEISRVRNLEKIQMGKYEVEPWYFSPYPIDFVDSDVVYICEFCLSYFGEVTQFERHRTKCHLLHPPGNEIYRDDYVSFFEIDGRRQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMCTRDEHGCHFVGYFSKEKESAEGYNVACILTLPQYQRKGFGKLLIDFSYLLSKREGKLGSPEKPLSDLGLLGYRAYWQEILVDILMEPGRSEANIEDLGAATAMTTNDVLHTLQNLNMLRYSKNQHVIVLTDAVIAQQERQKAKEKLKGKRSIDPDRLIWKPPVFSAASRTWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2QWH8</accession>
    <name>M2QWH8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TrmE-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_153254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705162.1">
        <property type="nucleotide sequence ID" value="XM_007706972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QWH8"/>
    <dbReference type="STRING" id="665912.M2QWH8"/>
    <dbReference type="GeneID" id="19131618"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_153254"/>
    <dbReference type="eggNOG" id="KOG1191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_3_0_1"/>
    <dbReference type="OMA" id="VQIGFHI"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000007">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="307"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD59459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="64205" checksum="1CD850C56AA257B9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2QXQ2</accession>
    <name>M2QXQ2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_41001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704538.1">
        <property type="nucleotide sequence ID" value="XM_007706348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QXQ2"/>
    <dbReference type="STRING" id="665912.M2QXQ2"/>
    <dbReference type="GeneID" id="19139885"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41001"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760779_0_0_1"/>
    <dbReference type="OMA" id="ASLETHW"/>
    <dbReference type="OrthoDB" id="5431422at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="370" mass="41056" checksum="F0A425AFDBA5F5ED" modified="2013-05-01" version="1">MQSLITAGADVNWEEPEGWLSQHRPVPGLNVFWTLLEDGLSSPRDEILLLLSNGLQLEKARADNGRTPLFGLVYEQQHDISLAEAFLTAGAKATAKDANLDTSLHFAGNRCFAELLFKFGAQVSAEDRDGFTPLHMACRYRRPDVAEFLLSKGATVDATTSEKQWTPLLLATDPRKNDTCIEDREQHEKLIELLFAHGANVQATTSDGRTVLHNAARAGNLDLVKYVVDHGVDVCAVTSNGKTALHLVGNLSRPHDPQIAQRLAIIHFLLEHGADINAQDQAGSTPLHDSWSCAHYYVHSSFQYDCRFSPDLFNLLLNKGADKLARDEQMRTPTELIDREKWMLDEDGFVCAKLKPVRSPPRRGGRGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2QXY8</accession>
    <name>M2QXY8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_164107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704211.1">
        <property type="nucleotide sequence ID" value="XM_007706021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QXY8"/>
    <dbReference type="GeneID" id="19132292"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164107"/>
    <dbReference type="HOGENOM" id="CLU_2223052_0_0_1"/>
    <dbReference type="OMA" id="DPMACSK"/>
    <dbReference type="OrthoDB" id="3662007at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024358" description="ShKT domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11623" checksum="70CD23A22CE35C71" modified="2013-05-01" version="1">MKLNTIFFAAMASFVLTGPLAVPNDVPALISEPKPADVTGNTESTGGEAINTTPARDCRQCDDFYRKCMGSTWCWYDPMACSKTCNLDTCRKFNKACTPCGYTDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2R4Z7</accession>
    <name>M2R4Z7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_39010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702171.1">
        <property type="nucleotide sequence ID" value="XM_007703981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R4Z7"/>
    <dbReference type="GeneID" id="19139398"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39010"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OMA" id="NGLQFCP"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
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        </location>
    </feature>
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        <location>
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            <end position="382"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD62234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="50858" checksum="58750EF9876B7C0C" modified="2013-05-01" version="1">MTTRHIDAEMGNEAADPTNFNAGIEKALPQEEAEPPSAYRPSEKPNQPALARVLSRRSAASFDPGPAPDGGVRAWIQVFCTHLTILTTFGFFTSFGVYQTYYEKTLGIEPSTISWIGSLQVFLLFFLGTFTGRATDAGLFRPVYIAGSCFQLVGIFTLAQCKSAWQIFLSQGVCLGIANGLQFCPSMALVSTYFVKRRAFALGFTALGSCTGGVIFPIIVQQCLPSMGFAWTIRIIGFIMLVVNITAIALYRTRLPPRKSGPLVDWASFKELPYTLYCAAAFFSFWGLYFSFFYIGSYARNVLGVSYQQSINLLLVQVAMGFLFRILPTYYADKIGGLNVLIPFAFICGIMMLAWIGIKSIGTLYVFAAIYGSGSAVIQALWPAVIGNLSREMDLKKTGVRMGMAFTIVSMSSLTGPPLAGALIQMNNGDYTYANVWAAMSFFVGGSLLVATRISLVGWDWRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RA63</accession>
    <name>M2RA63_COCSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_190951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
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    </dbReference>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        </location>
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        <location>
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    </feature>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EMD63769.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="609" mass="65169" checksum="B986DBFD2331A613" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RAH5</accession>
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        <recommendedName>
            <fullName evidence="2">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_358454</name>
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    <organism evidence="3 4">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007702683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RAH5"/>
    <dbReference type="GeneID" id="19138564"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_358454"/>
    <dbReference type="eggNOG" id="ENOG502SHVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_5_0_1"/>
    <dbReference type="OMA" id="YMGQMGY"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
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    </dbReference>
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        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF270">
        <property type="entry name" value="O-ACYLTRANSFERASE AUSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="456" mass="50478" checksum="6679F1E2A66F0D0B" modified="2013-05-01" version="1">MSGLPRGVDVLGQFPQLKTYNHGVALFPWREDLTQEIVISALREATGKILAAIPWLTGQVVHTEGENGTSGTIRVEPWPTDIPPHRLLKIKDATDLLPSYAEMCTANAPFYMLDGKVLCPYPGFPERYDTAVIGPAPPAMIQVTFVKGGFLLTYTNQHNVVDGTGLFTIITLLSAALRDEPFPEDIIAAANQDPGDVIRLLDPFEPILDHSWLLKPDPAPEFVPARPGGRWQNFLFRKEALADLKKLAEDPVGYDPDVPFISPNDAICALFWKSLASVRIKTGLAPSTVSKFNRAIDTRPVLGVSPGYLGQMVYISPSRLTFQELVDAPLSTVATRLRKDLDDVNNAFSARSYATFVDSVDDKMQLMYSGGMNLQTDVGHSSMMNAKVNGFDYGILGKSDFGRRPHLALTVNTFYIYPQEANGDYLILVCLPDMELKGLMEDPDWSRCTYVIEEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJ11</accession>
    <name>M2RJ11_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_301494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD66709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699936.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2RJ11"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_301494"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
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    <dbReference type="OrthoDB" id="6509636at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Firefly_Luc_like"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
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        <property type="entry name" value="AMP-bd_C_sf"/>
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        <property type="entry name" value="ANL_N_sf"/>
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        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
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        <property type="entry name" value="AMP-binding"/>
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        <property type="entry name" value="AMP_BINDING"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="23"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="445"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61273" checksum="046D6369BBAF5C06" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJN3</accession>
    <name>M2RJN3_COCSN</name>
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        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_135371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD66914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696707.1">
        <property type="nucleotide sequence ID" value="XM_007698517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RJN3"/>
    <dbReference type="STRING" id="665912.M2RJN3"/>
    <dbReference type="GeneID" id="19130968"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_135371"/>
    <dbReference type="eggNOG" id="ENOG502RY0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026939_1_0_1"/>
    <dbReference type="OMA" id="LGPKFMW"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
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    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
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    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="60"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="503" mass="56336" checksum="6F19C47D940CABE5" modified="2013-05-01" version="1">MVNNATAIEALRGDCPPPFFDQSKFGFGGFVDGRFCAPYGADGVCCLPCPLTDFLYPESFNTTYQVAEALNLVGLFCLVFLLISYIFLPAEKTRRHYLSYCLIIAAIFMALGFVIPFGAQPEQCYDEITPNDMYSSLTCAFSGAFLISGGLSMAVWIFIRALSMHLQICWDVTPGKRFFYCAQGLGWSVAAAFFTITITITGVSFRFGDVCHVNAEHSMKDFWGPLLAIAGAATVIQIATFVYCIKVYLQNMFSDDKTETQSSAGLPSYTTSIRNRSARAVYRRVRKVLYLQWRGITIVVFILVDVIFFSIVFIWLNSITQHAADNIADLAPFLLCLMKNADEPSPCFPLGQDLAIDQSTVTAVLMMLSIAGLQAFLLLVRWSMVTGWRDLILGKFSKNREFVSLDARNPTEDMRHFELKNFNHQSPPNAHITPEIASYVMNNPRSDTPDHFQKDIQREYKSPTLSFSIPRTQSRATHVDWDPRSSMARGGLGLHPPDYDSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2RP44</accession>
    <name>M2RP44_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_272350</name>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
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        </source>
    </evidence>
    <sequence length="422" mass="49614" checksum="C65E29742ACB147D" modified="2013-05-01" version="1">MTGKVQDKSRDKNKTRGKFNDGLSAEERKKRYDSKACLRCGEVGHFRRDCPKNEVKQGAVKIGMLRIATPYPTEEPDETLSDLDLYDEARQATDEAFELVQEAIRLQDFKWDDPLPTDWQVEGAEVLRRLRNQQCWIYGNAKHQANDCDIEGRVTITGPRAEEIACKAAQEQPRFKEPNDEETPRTFKERMEQHESLCWVDCPRQCDYHLRKREATRDNEDDCCHTNLWHNECRVLHCHMHQPGEKEAHEELCWVNCTTNCQFHQKQRRNARKVDDYYHSTISAEECNAKHCKMHRAQKPRVTTTRMPKQVLRKPNKDKSHERLLWTHCRKGCAFHRQQFEDARGVNDHLHSTLSANICEAMDCPIHKVKKPRPTREIAKQEIPHQNTHWSFCYDDQCMIHYSAKAGEGYFPTQKKSRQSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSM5</accession>
    <name>M2RSM5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_106248</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694860.1">
        <property type="nucleotide sequence ID" value="XM_007696670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSM5"/>
    <dbReference type="STRING" id="665912.M2RSM5"/>
    <dbReference type="GeneID" id="19129991"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_106248"/>
    <dbReference type="eggNOG" id="ENOG502RZMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044125_2_0_1"/>
    <dbReference type="OMA" id="GHACMVA"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="272"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="309"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD69574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="386" mass="41058" checksum="082634D8CC588688" modified="2013-05-01" version="1">MVQTNTTGNPLSAGSLALFMATSLPKSEASQLKNGTEAVALAVHAGMLAVGFRLIGLGEDERIEAHADAEDPKELPAQWNASSSYAFRYAHAQSAMEFLVKVNRLGGKAVIFALAVGDDKTTHFELTTKDYLSESQLPFSVPEGTSIEDASRKLQDLFISPGRLNDLGSLLKISVIQKLAPRLNKPGYEESTMDQERTPTADRQDPQRSDPPNPRQPPADPDPARPHPFNDPLAAPQRSGRHVPEPIPGFDDELDLNRQPGRLQDNRNPINIGHDDLYPQGLGPNDPLRPHLAGGLPRPGGFGGGGMHPTFDDPLFRGQGGQGGYDPMAPPGARYDTFGPGDPRAEDRGRVPRFPGGGGGGGFGGPGGFGGRPPNPFGGFGDGDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2RTV9</accession>
    <name>M2RTV9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_41722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705562.1">
        <property type="nucleotide sequence ID" value="XM_007707372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RTV9"/>
    <dbReference type="GeneID" id="19140050"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41722"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="EFHSCDV"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="285" mass="29251" checksum="436268B461C6F675" modified="2013-05-01" version="1">MASAEQDVRLQDFANIFSLKGKVAVVSGGSRGLGLHAASGLMQAGCSKIFITSRKASACDAAAAALNALPNKFPGAKAYSVPADSSKVSEIVRLVGEIAKHTDHVDILFANAGATWGSRFDAVDEKNGWDRVMDLNVKGVFFTIQKFAPLLTKAASVQDPARVIVTGSVAGIGTGSVGGDSAAFSYAVSKAAVLHLVRNLAVELGPRHVLVTGIAPGFFASKMTDVVMQQAGGEEALGKATPNGRVGRPEDIAAAVVFLSSRAGSHVNGDTIVLDGGKIHGGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2RV25</accession>
    <name>M2RV25_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_262123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705417.1">
        <property type="nucleotide sequence ID" value="XM_007707227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RV25"/>
    <dbReference type="GeneID" id="19135447"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_262123"/>
    <dbReference type="HOGENOM" id="CLU_141732_0_0_1"/>
    <dbReference type="OMA" id="DEHCRIQ"/>
    <dbReference type="OrthoDB" id="10294921at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="157" mass="18012" checksum="6DB3804BFCBC403E" modified="2013-05-01" version="1">MDEHCRIQATGCINPRILSQPWTRKPKDCCSAFKATAENPCEGRWTVVLTHCNMVGMSLGRCARLIDLMLTEEPVIRVFCIFLSLYVRRRMASRIGLGREEVTIQRGQSCIGHHCPLCGSWWPLLLLYFVYFIEGRLFNLHPIHMSCMNESVYCAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXQ4</accession>
    <name>M2RXQ4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_347613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704803.1">
        <property type="nucleotide sequence ID" value="XM_007706613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXQ4"/>
    <dbReference type="STRING" id="665912.M2RXQ4"/>
    <dbReference type="GeneID" id="19137848"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_347613"/>
    <dbReference type="eggNOG" id="ENOG502SVM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555465_0_0_1"/>
    <dbReference type="OMA" id="HTIVTHA"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="575" mass="63312" checksum="B99D3F36CCD96EEE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZE0</accession>
    <name>M2RZE0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_40062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703602.1">
        <property type="nucleotide sequence ID" value="XM_007705412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZE0"/>
    <dbReference type="GeneID" id="19139635"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40062"/>
    <dbReference type="eggNOG" id="ENOG502SHIH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012049_0_0_1"/>
    <dbReference type="OMA" id="ELQCNPA"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD60418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="679" mass="75877" checksum="A22DF7FE9985865B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2S342</accession>
    <name>M2S342_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_39290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S342"/>
    <dbReference type="STRING" id="665912.M2S342"/>
    <dbReference type="GeneID" id="19139465"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39290"/>
    <dbReference type="HOGENOM" id="CLU_382164_0_0_1"/>
    <dbReference type="OMA" id="IKASAMF"/>
    <dbReference type="OrthoDB" id="5396941at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488:SF2">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488">
        <property type="entry name" value="ZGC:162509"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="167"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="724" mass="79730" checksum="35A2F23B00F0F696" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2S3K2</accession>
    <name>M2S3K2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_96771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703022.1">
        <property type="nucleotide sequence ID" value="XM_007704832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S3K2"/>
    <dbReference type="STRING" id="665912.M2S3K2"/>
    <dbReference type="GeneID" id="19141700"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_96771"/>
    <dbReference type="eggNOG" id="KOG3208">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_078034_1_0_1"/>
    <dbReference type="OMA" id="QAYAVND"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD61763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="224" mass="25315" checksum="4468AB95C7BD07BF" modified="2013-05-01" version="1">MSSTGGGWAQLRQQARTLEQQTETLFHTYSQFGSTPNIPAKPSEEELRVETRLQEILEQRDALVAQLSRLLDSESTHGSSAVKQNNLARHREVLSDHRRELARLKSSLNDARNRANLLSNVRSDIDAYRSANQAEADYMLDERNRIDNSHNMADSVLSQAYAVQENFAIQRDTLANINRRIVGAASQVPGINSLMGRIGSKKRRDGIILASFIAFCFLMLLWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2S626</accession>
    <name>M2S626_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_222291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701909.1">
        <property type="nucleotide sequence ID" value="XM_007703719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S626"/>
    <dbReference type="STRING" id="665912.M2S626"/>
    <dbReference type="GeneID" id="19134612"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_222291"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_2_0_1"/>
    <dbReference type="OMA" id="GEKTGFW"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD62573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="229" mass="24265" checksum="1F1C7D47C95AF74C" modified="2013-05-01" version="1">MSKPSILFILTSHNKLGDTGKPTGWYLPELAHPYHVLRNKANITVASPKGGEAPLDPASVEAAKDDVSVTFLKNDEQVWKTTKKLSDYIGKASEFDAIFYVGGHGPMFDLADDATSQQLIREFWEAGKIVSAVCHAPAVLYNVKLSDGSLLVAGKEVTAFTNAEEEQAGLTKAVPFLPEDALQKASGGKFVKAAEPWGEKVVVSGKLITGQNPASATGVGEALAKALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8H3</accession>
    <name>M2S8H3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_153583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705360.1">
        <property type="nucleotide sequence ID" value="XM_007707170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8H3"/>
    <dbReference type="STRING" id="665912.M2S8H3"/>
    <dbReference type="GeneID" id="19131632"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_153583"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042423_0_0_1"/>
    <dbReference type="OMA" id="RWICFIL"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="268"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="159"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="278"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD58890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="367" mass="40863" checksum="B2B47FF90BA44499" modified="2013-05-01" version="1">MSQNYQQYGGNPYGQAEEYGAHSNPYGGSGGYGSSNPYSGGYDEPQQQLNPPAPLQRHGESNYSQPSQYSQAGALSPAQTNGQNVPHTDVPLNGLPGQGNTIEAPGSQPLSRDDFFTRIEGAKQRIGQLTSDIQAIANIHQRMLSSPDNRSSAELEAIVTNTQIRNTQIKDEIKFLEKDALRDPNDRTKRSQVEALKRTFKSQLEDFQKEEADYSKRYREAIGRQYRIINPDATDAEVEEVANADLGDEGIFTQALKSNRSGQAASVLGAVRARHNDIQRIEKTMSELALLFTQLNEQVMYQEPQIQQAEQQTVQVKDDTENANKQLEEGIKSARRARKLKWYILLTVIAILCVIALVLGLYFGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8N4</accession>
    <name>M2S8N4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_176177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="Salamov A."/>
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        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_37078</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699862.1">
        <property type="nucleotide sequence ID" value="XM_007701672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SB06"/>
    <dbReference type="STRING" id="665912.M2SB06"/>
    <dbReference type="GeneID" id="19138890"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37078"/>
    <dbReference type="eggNOG" id="ENOG502S85C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347200_0_0_1"/>
    <dbReference type="OMA" id="KKFWVAQ"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000246">
        <property type="entry name" value="Telomeric repeat-binding factor 2-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="10">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="11">
        <location>
            <begin position="727"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="649"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="693"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD64498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="815" mass="92142" checksum="744E31841E7507FF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDA0</accession>
    <name>M2SDA0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_303742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698474.1">
        <property type="nucleotide sequence ID" value="XM_007700284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SDA0"/>
    <dbReference type="GeneID" id="19136231"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_303742"/>
    <dbReference type="HOGENOM" id="CLU_2654326_0_0_1"/>
    <dbReference type="OrthoDB" id="10580827at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="76" mass="8679" checksum="A39C38D751C3F26B" modified="2013-05-01" version="1">MSGSTFNDMTKYLLDFDIFTVLIFPCAYFLWEFLLLVVVSYAVIPPIELNILSRPALALTALRLITRRDNSGRAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SDR1</accession>
    <name>M2SDR1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_98369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703904.1">
        <property type="nucleotide sequence ID" value="XM_007705714.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SDR1"/>
    <dbReference type="GeneID" id="19141785"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_98369"/>
    <dbReference type="eggNOG" id="KOG1359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
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        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="34"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="418" mass="45542" checksum="4D990C767F614455" modified="2013-05-01" version="1">MPNPPTPLEQTLHTHLTSRLHHSTLRTLSLPLPHQIDFSSNDFLSLSTSHPLRALFLSLLPHHPLGSGGSRLLDGNSALAESLEASIASFHGADAGLLFNSGFDANAGFFAAVPQKGDTVVYDEKVHASVHDGMRLSRAARRVAFRHNSIEALRGVLEAERDKAGRCNVFVAVESVYSMDGDVAPLREMVDVAEEVLGKERAYVVVDEAHATGVLGLRGRGLVSELGLEGRVFARLHTFGKALAGNGAILLGSHTLRHYLINYARPLIYTTFLSYPSLVLIQASYEMLKSGQSEKLQANLHDLIRTLYAKLEGLQKTSSHACRLLKIPSVCPRSPIFAVQLTNPKALASSLQEQGMMVRAVVSPTVPIGTERVRICLHAGNTVAEIEKLVLALKRWCESQAEGNTERQPLDPSKRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEC3</accession>
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            <fullName evidence="3">DUF7820 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_123920</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703204.1">
        <property type="nucleotide sequence ID" value="XM_007705014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SEC3"/>
    <dbReference type="STRING" id="665912.M2SEC3"/>
    <dbReference type="GeneID" id="19130575"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_123920"/>
    <dbReference type="eggNOG" id="ENOG502SJP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011816_1_0_1"/>
    <dbReference type="OMA" id="YAMYPQN"/>
    <dbReference type="OrthoDB" id="5384459at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056722">
        <property type="entry name" value="DUF7820"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078:SF1">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25130">
        <property type="entry name" value="DUF7820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7820" evidence="3">
        <location>
            <begin position="445"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD60815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="786" mass="85536" checksum="AB909C55E2DF979E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2SED4</accession>
    <name>M2SED4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_174157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SED4"/>
    <dbReference type="GeneID" id="19132896"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_174157"/>
    <dbReference type="HOGENOM" id="CLU_2722052_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="72" mass="7922" checksum="7AED6E27313A8C20" modified="2013-05-01" version="1">MPLIEFISYCFYVINTAFGGRVAVGRIMVVLPISSIRVTSTLPKGFREGCCPGAIRAVVWAELRRIQDGSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEE2</accession>
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        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">COCSADRAFT_236440</name>
    </gene>
    <organism evidence="9 10">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_236440"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_027816_3_0_1"/>
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    <dbReference type="OrthoDB" id="294730at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA_transpt_TM"/>
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        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="90"/>
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    </feature>
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            <end position="167"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="262"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <end position="462"/>
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    </feature>
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            <begin position="66"/>
            <end position="457"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD60835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="484" mass="52698" checksum="6DA8E018BDAE9875" modified="2013-05-01" version="1">MGLKAFLKKEQKTSSDGDVASDYPPSEKDMEAYGHNTDITTGWTGDGHAGASEYPNASGENYRTLGRWRACVILITIEVGIGILSLPQALQTLGLIPGIIAILGFGGLTTYCGYILLQFHRMFPMTTNLVDCALYVGGKPFEYFLGVAFIFNLVLICASANITLSVALNTLSNHALCTVAFMAFPHILCWLLCIPRKLTFAAAASWICTISIVAAVMIVMIALGVSGPQAPPDFKVSIILVGKPTFVQTVNALLNIAFAFAGNQSFISVMAEMRDASRDFPPALYMQKGFEVVIYIVVACVIYGLAGDATTSPALGSAPRLTAKIAYGILIPSVLGTGLIIGITAIKYMYITIMRIAKPEQVNVHNTFTWMLWIGIGTLFWAVSFVISNAVPIFSSILNISSAIFVSWFTFGLTSIFWLHMNWKVQWSTPWKKFLAIVNYAIMLMTIFLMIGGLYTSLKALIEIYNDPDSNLSGPFTCSDNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">Methyl-accepting transducer domain-containing protein</fullName>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705150.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19132239"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163392"/>
    <dbReference type="eggNOG" id="ENOG502RYNN">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483094_0_0_1"/>
    <dbReference type="OMA" id="RTNTECH"/>
    <dbReference type="OrthoDB" id="3695732at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024941" description="Methyl-accepting transducer domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
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                <person name="Ohm R.A."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702180.1">
        <property type="nucleotide sequence ID" value="XM_007703990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SH85"/>
    <dbReference type="GeneID" id="19134187"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_201337"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OMA" id="HEFAILQ"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD61775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="367" mass="41450" checksum="0AD248E073784EEE" modified="2013-05-01" version="1">MINYSRWINPPVSLVKSVEDSRAVYRKLGNSGLIVSNPILGGLHFGASQWYDWVLDEKESISLLKAAYDKGINTWDTANFYSNGESERIMGKALKVHNIPRSKVVIMTKCGRAVTDPNVDPDIGTCTAYHPDLANKSKDYVNHLGLSRASIYQQVEASLQRLNTDYIDVLQIHRFDDQVPAEETMKALHDLVQMNKVRYLGASSMLAHEFAILQHTAEKNNWTKFVSMQNHYNLIYREEEREMNKYCKRTGVGLIPWAPLASGKLARPPGQPTSSYRSVNGTLYKDNNPSQSDEIARRVYEIAVSRSIPMSHVALAWLNKRVVSPIVGLSSVERMDEILDARAVELSDEEETYLESAYHPLPIQGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHG9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_158731</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66643.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_007698076.1">
        <property type="nucleotide sequence ID" value="XM_007699886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SHG9"/>
    <dbReference type="GeneID" id="19131915"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_158731"/>
    <dbReference type="HOGENOM" id="CLU_1384048_0_0_1"/>
    <dbReference type="OrthoDB" id="3668237at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="197" mass="23660" checksum="F5E4744A238F1956" modified="2013-05-01" version="1">MEPHFLNLPPEIRNLIYEYALAQNHGLCYKWSNCAYRLRIRNEEFEKIEEEENDDEDEMGHCWEEDDEMDVDEREYFEWKYFESIADENSSLTKKDSINQSRFQSDGYGQDKNGYTLAHSKLDMEALTDGGDYEVKEKMTVPQILLVNQLQLVCRRLYSETKGLELRYNTVFFAGDKYNIEPFYQRYARFLRRPLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIE2</accession>
    <name>M2SIE2_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_283517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696748.1">
        <property type="nucleotide sequence ID" value="XM_007698558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SIE2"/>
    <dbReference type="GeneID" id="19135847"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_283517"/>
    <dbReference type="eggNOG" id="ENOG502SH1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052682_0_0_1"/>
    <dbReference type="OMA" id="LVHTTNM"/>
    <dbReference type="OrthoDB" id="5419666at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="285" mass="30931" checksum="445C731946D5B97A" modified="2013-05-01" version="1">MSLARAMTKRMKRSEEPKEPTSPTRPTRSQSVKNGSSIDRAKISLPVALVSTTNMLSYNAPDISSLKNASSMASLTQTSSADDSDHSVSTRSRASSHASRDTTLTDASSVDLSPISPVPNYAGGFPSGGKPLRKSASTTSLKQVKEEIIEPVPTIPARALSHSKRAHERLAHKRSLQNVGTRGSISSRGSVGSVRSSREQRSSLDMFKATIEEESHPFGRELEQLNEVVEEFGGVVRDAEAEADRFAMLSRNLAAYCAADYLVEIRPLFSQRFGMPHQAPAMAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLG2</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="19139134"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37970"/>
    <dbReference type="eggNOG" id="ENOG502R29K">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="EMD58326.1"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD63555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="665912.M2SMN6"/>
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        <property type="entry name" value="AMIDASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="536" mass="57918" checksum="11E6D33FF99B8EAC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNQ0</accession>
    <name>M2SNQ0_COCSN</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_103986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705860.1">
        <property type="nucleotide sequence ID" value="XM_007707670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNQ0"/>
    <dbReference type="STRING" id="665912.M2SNQ0"/>
    <dbReference type="GeneID" id="19129880"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103986"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_1_2_1"/>
    <dbReference type="OMA" id="YYERPLE"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD58402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="232" mass="26151" checksum="FE0D0C6CE1D539CB" modified="2013-05-01" version="1">MLDGLLKSAKDNTEASYARIVNQELFLTFAAAGLFSVVVCQLILSALGHPEYLEPLREEIGNAVRECGGWNKDACSRMPKLDSFLRETLRLSPPTALTLQRKVDVDIPLSNGEVIKAGTLIGFPTLAIQRDEEYYERPLEFDGYRFYDADTNTAKVKSVTQSRTYLPFGYGTQTCPGRFLATETSKIVFAKFLVDYEMRFTPKRIGKPVDWPIGGQIMPSIDAYVSFRLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP05</accession>
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        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_320343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD64025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP05"/>
    <dbReference type="GeneID" id="19136612"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_320343"/>
    <dbReference type="eggNOG" id="ENOG502RFID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_0_1_1"/>
    <dbReference type="OMA" id="WGVFHAT"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18820">
        <property type="entry name" value="GH43_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD64025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="401" mass="43996" checksum="69488EF8302A9E98" modified="2013-05-01" version="1">MAQQMQPIYQGQRPPYNDSILTITKRSCADPYVLWDKGTYYMTFTCGGHIEIWSADSLFDFEERSKKTVIWRPPPNQPYSGDIWAPELHSIQGRWYVYFAADDPKHGNKSHRMFVLAGPPSDEDPLEPSKWNFFGRLGGLPEHQWAIDGTVIYLHGSMLFVYSGWPLGTEADESRQEIFIIEMVSPTECTGHPIRISTPDLQFEFSGSSGINEGPQFLASPDGRWMGIVYSCAGSWTHEYKMNVLYYTGGHPLDPHSWAKSNVPLLKAARDDSPPYGPGHGNFVLVNGPGGPEVWGVFHATDAKTGWEGRKARVMRVGWGNGGPFMGSGECGRCCSEVQHFIQGCPGGTCGGQGHCGGEGGAGGGYLEPGKQGGGNPTEDLKREVKNLVKGGKGLISKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPH2</accession>
    <name>M2SPH2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_89539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700064.1">
        <property type="nucleotide sequence ID" value="XM_007701874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPH2"/>
    <dbReference type="GeneID" id="19141302"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89539"/>
    <dbReference type="eggNOG" id="ENOG502SNXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049915_0_0_1"/>
    <dbReference type="OMA" id="GSDMFCP"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="178"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="285" mass="31663" checksum="924C3D8F53B1BCC9" modified="2013-05-01" version="1">MVDYSEAGLVETFDKLASEGAIVFGPHKIVSVEDNGYPLEFRICPALATKPHTVGATNHGFNKARKWGPGSDMFCPDERLIITQLNDTHDLALNLFCVDRPQLLMLTLDSYKRQHEALDMDDFVVMLQVLRQFPSMYAIFNCGEKGGCSRVHKHLQGLKGPPHAFDYLISAISRKENKVPFRYFVHHFDEGFKKTSASAVLSVYTTLLTQCQSAPDTKEENAPPHNVAMWADHLIVIPRRSGSTEGASANTGGMLGSVWVTSQEQVDEWLRIGCANVLRELGVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPW2</accession>
    <name>M2SPW2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_32020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694173.1">
        <property type="nucleotide sequence ID" value="XM_007695983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPW2"/>
    <dbReference type="STRING" id="665912.M2SPW2"/>
    <dbReference type="GeneID" id="19136604"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32020"/>
    <dbReference type="eggNOG" id="ENOG502SWBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877181_0_0_1"/>
    <dbReference type="OMA" id="RNWWERW"/>
    <dbReference type="OrthoDB" id="5420214at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="317" mass="35073" checksum="6010E50AE91E876A" modified="2013-05-01" version="1">MESQLPPPPASAILAPPSQHHQPQPQHYHRLSSPAANCDYDYTYQYNEKDHHHHSSAHSDRLSRSSNRRPHDSVISHPFSPKPSSPPSPSSNSSISSVGHHRNSSNAHRYSSSQLERQSLSYPPQAHIDPEKHAEALAHGYRAPNRLSAVPSGGDAIVYDKGAYQEKGPEEKAWQLLLWLCGPCAFLSAVIAIWTFCALFITLLLSPLRLCTTRAPLSEQIKSFLAPSLNLQLHMVYSHDSTSGYSAPMLVVIHLFSPIVAFGVAIAAWTAAGFWFFSCILGDPGGHDGHNDGRESIVGVRNWWERWLSRGLRETDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ84</accession>
    <name>M2SQ84_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_37040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699851.1">
        <property type="nucleotide sequence ID" value="XM_007701661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ84"/>
    <dbReference type="GeneID" id="19138879"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37040"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OMA" id="WKHQRRT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD64460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60071" checksum="D55318BF43175780" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQP5</accession>
    <name>M2SQP5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_102091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705149.1">
        <property type="nucleotide sequence ID" value="XM_007706959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQP5"/>
    <dbReference type="STRING" id="665912.M2SQP5"/>
    <dbReference type="GeneID" id="19129777"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102091"/>
    <dbReference type="eggNOG" id="KOG1405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="OMA" id="GLMCAFD"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD59441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="511" mass="56418" checksum="9127F7784DA2E4E2" modified="2013-05-01" version="1">MASLLRTAGRSRAILPRVNAHTASRVPMTLNRRYATAAAAVATDSGEQSFFPDEPKLPIVKTQIPGPNSQKAIEKLGKVFDIRSLNMMADYSRSYGNYIADLDGNVLLDVYAQIASIPVGYNNPSLLLAATSPEMASAIINRPALGNFPQHDWADILESGILSVAPKGLNQVFTAQAGSDANELAYKAAFMWKRQQQRGGADADFSAEDIASSMNNKSPGAPDMSILSFKTGFHGRLFGSLSTTRSKPIHKLDIPAFDWPQAPFPQLKYPLAEHEAENRREEQRCLDETEQLLMNYHNKPVAAVVEPVQSEGGDNHATPFFFQGLREITKKHNVLLIVDEVQTGVGATGKFWAHEHWGLSSPPDIVTFSKKAQTAGYYFGNDDLRPNKPYRQFNTWMGDPARAILFRAIIQEIQRLDLVSSTAATGDYLFSGLERLAEKYPAEIQNLRGKGQGTFIAFDSGRRDEVLKKAKGQGVNIGGSGERAVRLRPMLIFQKQHADLLLERLENVFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQT0</accession>
    <name>M2SQT0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_32282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694250.1">
        <property type="nucleotide sequence ID" value="XM_007696060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQT0"/>
    <dbReference type="GeneID" id="19136714"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32282"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_2_1"/>
    <dbReference type="OMA" id="YLQSHEW"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF28">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39861" checksum="A770253B0C84F896" modified="2013-05-01" version="1">MGALLDARATDFPKRDQFGHRIINPYIYDPSCALAIVGTTIIVLLSIYSVTQYLRHRSWFFWAAIIGVLMLDLGFICRTVSSYDEGKESPFLVSWLMILLAPSFLAAACYMSFGRVIWFSCPTEALNFKTLWCWPEWITPTFVAFDMFSFLVQLIGASQISRHYDKAPNGDRTISISEQAALPGRVILILGLVLQMLCFAIFSVVSIRYFYMSRKWAAYDLGDMHLWRKLSYTINLSSILIALRAVYRTMEIPHDRDYGMRYLQSHEWCFWTFDAAPIVCVLLIFAIWHPGRYLPRSYTGLRLDKVRAVKEKDEISMYSASTCGQDTELKEYKPEDFRHVSVAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRB8</accession>
    <name>M2SRB8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_88562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699394.1">
        <property type="nucleotide sequence ID" value="XM_007701204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRB8"/>
    <dbReference type="STRING" id="665912.M2SRB8"/>
    <dbReference type="GeneID" id="19141254"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_88562"/>
    <dbReference type="eggNOG" id="KOG2946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059592_0_0_1"/>
    <dbReference type="OMA" id="VVTMQIK"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="152"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD64835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="290" mass="31278" checksum="3F11FF34DED706AC" modified="2013-05-01" version="1">MPSSATSANPYDDDAVERDLIDPDDATLDDLDDPLQGTSDRAPLTGNIQRNAAQTQSYLTSSIPGEDRRAPTNTIDETVWETLSRDIFAIWEKMKQVLYPKYLLGGMMQRGGGIGAAERGEADGVGGRLRNIAGRWPDADVILQGGMSEGLRDWDLWGPLIFCLLLSLFLSWGAKGDQKDLVFSGVFAMVWIGEAVVTLQIKLLGGNIAFFQSISIIGYTLFPLVIASVLSAVGIPVIVRIPVYVVLIAWSLAAGVSIMGGSGVVRNRVGIAVYPLFVFYVALGCLCFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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    <name>M2SRD2_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_177501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696842.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19133090"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_177501"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235339_0_0_1"/>
    <dbReference type="OMA" id="HAMTWLE"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="605"/>
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    </feature>
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        <location>
            <begin position="996"/>
            <end position="1042"/>
        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="738"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2003" mass="220982" checksum="3AA1416EA51566D7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
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    <feature type="chain" id="PRO_5004025278" evidence="1">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="189" mass="21202" checksum="36EEF7B0C1B4B066" modified="2013-05-01" version="1">MHTTTLITLFLTTLTTAHLLPPQPPHPYILPRAAPSIQDQCTFTLYHKQISANPRKNYIYLPTLTDHANNIVIDIAATRPAQERNSYTRLSVTRKYAVKGLLGGETLTISARDGGDGLGFEMGDLRWEAEGKEGGVEEMEGEVGCRVGEWVESGLINRERKLECAFPCGKIDEAEEEEEEEEEEREELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS90</accession>
    <name>M2SS90_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_152162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
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                <person name="Sun H."/>
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                <person name="LaButti K."/>
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        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="364" mass="41702" checksum="892CF6F64815BE26" modified="2013-05-01" version="1">MSHPDDKVSMDYGPARNRFPTLFEVLSRKTVAPLDLFSFYIYMRDQQRSVDYLDFWLDVSQHLQLCRLYVRRLHRSMIEGTPDLDNNRYSTFAMDNAGEGPSNEKGDNMSDQRLSAFLRSERGSPNHSPQHSQGSNQTGDFQRPSPYVSETPGDSNSPGHNSSFDNTQPGREDLRASAEKILYTYLLPGSEREIIIPQSILSDVQEAIEGPEQRADPELFDQAKDYVFQAMERDAYPGFLQNKGLGNLVPQSMMVRLIVGLISFFAAMWTSFILIFLDKSRATRCWIILPFTIAIYLIFTHQYMLDPIIALAGYSEYTFFDFNKIREPFVKKTLARRSLTVLLMFLVVTVALCCLFIFVPGKRL</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="310" mass="33922" checksum="E59C3AAE15F69C25" modified="2013-05-01" version="1">MGLNYYASSPTVVLPPQQPQGYFSHHQNTAASPMGNFRPKYPTPPSLNYLAAVSNATAGRKRSIADVDEPEENLPVGSIVTQAPAKPKPEPVYGPGMTLIYPGEPGYALAAESQSGTWYEEKIEKEEKAEAAARPIAISRKSVRMSPSANVEVPSLNDMDAQKTEELIDDNGTTINKLISSLGVGWKNVMSNPNLRDAARAYSRVIERHFDFTDVLVMLEKESLNAYLVRAKQHGVQGYWLFSDSLQWCQLVGWSLERTVNNLMFGATPRVEGERINARQLTPSSPASTPAAQPAVEIPSTNADVDAMEM</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="50" mass="5479" checksum="4E33725FAF9C628E" modified="2013-05-01" version="1">MTLLLNKHGDEVQITQEVVVAATQNDDSSKEVIALLLNKRGDEVQITEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2STK2</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
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    </dbReference>
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            <end position="22"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD60337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="51416" checksum="217869C1727D5DCC" modified="2013-05-01" version="1">MSLTMRSVLSTAVLLLAGSAAAQTLTPTPTSTSSVPRRTTSAPTTASSPTFTAVSDCHPHKTVLWCMVGEEEYQVSGPTATEEFQSQYTDCHSHSSGVYCVDNRGEDVKILVDGAGEGSHSTEGDSHGHGEEPAAGSASESGNSGQHCHEHAGIPHCVGGSSGPVCEAPDRDYNIGLRVGLLFVILVTSGIGVFTPVLTRKFNLVSADNIIFVVLKQFGTGIVISTAFIHLFTHAELMFSNECLGRLEYEGTTAAIFMAGLFLSFLVDYLGARFVQWRQSKHSSSGTEVPAVAGDNKSGEVASTPSSDQGSDHGHAGHAHGPMRIATPMEQKINVINLEAGIIFHSILIGITLVVASDGFFITLFIVILFHQMFEGIALGTCIADLPKAAAGTLQKLIMAGTFALITPIGMAIGIGVLDHFNGSDPSTLVAIGTLDALSAGILAWVGLVEMLARDWMSGKLMDAGLIRTLSAMFALVAGLILMSVLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUH7</accession>
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        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_40323</name>
    </gene>
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007705477.1"/>
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    <dbReference type="GeneID" id="19139700"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40323"/>
    <dbReference type="eggNOG" id="ENOG502SMU4">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
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    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
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            <begin position="12"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="357" mass="39763" checksum="0B68ABF7F12BFC5C" modified="2013-05-01" version="1">MAQEKEIGIVGGVTASLGILMTMAAFLAISLYNVIETMFLIFAVFKQRTGLYFWSFFIATFGIAPHAIGFVLKFFQVTKIDLLSSAIIGIGWACMVIGQSVVLYSRLHLVVRDKARIRWVLYMIIFTGVVLGVPLFTLAMGANSKHSARFLPSFLIYDKIQLVVIVVQETIISLIYIYETVLLLGGHDGKAPEPIKKLLRHLIIINVIVLIFDITLLAVQFSGHYQIQTTYKTAVYSVKLKIEFSVLNRLVSIVKHKDLLSNRRTLGTNSLNLSRWTECKKSHPDTGDNNTGPFTKMDELSLRCQSRKESVKTFEASVDHIGLIGPGDGSTPDLELGTGQLLAPEKAKSIKLTQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUI7</accession>
    <name>M2SUI7_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_98550</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUI7"/>
    <dbReference type="GeneID" id="19141802"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_98550"/>
    <dbReference type="HOGENOM" id="CLU_3147158_0_0_1"/>
    <dbReference type="OrthoDB" id="10375726at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="49" mass="5788" checksum="2B73B88459247379" modified="2013-05-01" version="1" fragment="single">YNFKITYRVGTLNRVVDALSRRSNLREEGYKELYNALLKTMLDGSLKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUM3</accession>
    <name>M2SUM3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_148891</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703162.1">
        <property type="nucleotide sequence ID" value="XM_007704972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUM3"/>
    <dbReference type="STRING" id="665912.M2SUM3"/>
    <dbReference type="GeneID" id="19131466"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_148891"/>
    <dbReference type="eggNOG" id="ENOG502S890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177920_0_0_1"/>
    <dbReference type="OMA" id="SQMWANY"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD60766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="72" mass="8337" checksum="068E2BE4309710AD" modified="2013-05-01" version="1">MESPHEHQQSQLLSRIIVNVEKLNEAIMMLNKNLQEINIQNMDTELVAQMFKNYQSNVLFHLEATNGLKDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUR7</accession>
    <name>M2SUR7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_123923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703205.1">
        <property type="nucleotide sequence ID" value="XM_007705015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUR7"/>
    <dbReference type="STRING" id="665912.M2SUR7"/>
    <dbReference type="GeneID" id="19130576"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_123923"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_0_1_1"/>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD60816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="460" mass="50912" checksum="0F18F1840E0A0EE9" modified="2013-05-01" version="1">MAARPSNIGIKAIELYFPSQCVDQTELEKFDGVSAGKYTIGLGQTKMSFCDDREDIYSLALTTVTSLFKKYNINPKNIGRLEVGTETLLDKSKSVKSVLMQLFEESGNYNVEGIDTMNACYGGTNALFNSVNWIESSAWDGRDAVVVAGDIALYKKGAARPTGGAGCVAMLIGPNAPLVMDAGQRGSYVRHTYDFYKPDLKSEYPIVDGHFSLRCYTEAVDACYKAYNEREKTLKARQNGNGVNGSSHELETPLDRFDYMAFHAPTCKLVAKSYARMLYNDYLVNPTNPIFAEVPAELRDLDYATSISDKTVEKTFMGLAKKRFAARVQPSIQVPTECGNMYCGSVYGSLCSVLANVNSQDLQGKRIGLFSYGSGLASSLFSFTVRGSTENLTKQLDIHNRLANRRVVAPEVYDEMCNLREQAHLQKDYTPKGNPETISSGVYYLTGVDSMFRRSYAIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SV93</accession>
    <name>M2SV93_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">COCSADRAFT_39690</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703084.1">
        <property type="nucleotide sequence ID" value="XM_007704894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SV93"/>
    <dbReference type="STRING" id="665912.M2SV93"/>
    <dbReference type="GeneID" id="19139544"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39690"/>
    <dbReference type="eggNOG" id="KOG2415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009667_4_0_1"/>
    <dbReference type="OMA" id="INFQNCV"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="589"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMD60986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="629" mass="69684" checksum="6F5418140D822040" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVR1</accession>
    <name>M2SVR1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_59867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    <evidence type="ECO:0000313" key="1">
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0005777">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Dimeric alpha+beta barrel"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="328"/>
            <end position="552"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD66600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="565" mass="63812" checksum="57608FABE26382CB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWN3</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698122.1">
        <property type="nucleotide sequence ID" value="XM_007699932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWN3"/>
    <dbReference type="STRING" id="665912.M2SWN3"/>
    <dbReference type="GeneID" id="19141047"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85211"/>
    <dbReference type="eggNOG" id="ENOG502QPQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030747_0_1_1"/>
    <dbReference type="OMA" id="WSIYDAQ"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="216"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="448" mass="50109" checksum="954CE4C9AF837A77" modified="2013-05-01" version="1">MTNKSYLAFLDNTTASDMLSRTTVPGLAALPSLIPHRVRRKWRATKSRIRSRQSPTSSIASLETSFSPSDTLRSLRTHSWSIYDAQYLFLAIVAIFSLSVSEAPGPFAKTFVATLLMTGLCLPITRQFLLPLLPTLTWLFLFSSCKYISEDYRPAIWVRVLPALENILYGSNLSNILSAHKHTVLDILAWLPYGVVHYVSPVIVSACMFIWGPPGTLPIWARAFGYMNITAVLIQIVFPCSPPWYENTYGLAPANYSIHGDAAGLKAIDKLTGIDIYTSAFLGSPMVFGAFPSLHSGWATLETLFMGHVFPRLFPVYVFYTMWLWWSTMYFSHHYAVDLVAGSLLAGVCYFFGRANFLPRPQADKEFRWDYDFVEIGDPMDRAGYSMLDIYEEFPPNSDSDDWATGSSSSYSTGGRSPIGARSPTDDNQSLWDGDTVGSDTEHTLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX63</accession>
    <name>M2SX63_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_231373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702779.1">
        <property type="nucleotide sequence ID" value="XM_007704589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX63"/>
    <dbReference type="GeneID" id="19134778"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_231373"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="OMA" id="QPDEIWS"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="502" mass="53768" checksum="F5C53E9E512E0BB3" modified="2013-05-01" version="1">MGNAVSAAQSGVSTFTGGSAGIAGSAIHQCLIKAVGDDNAAFKGDPLYQVNDVKPYNLDIMITPTAVTYPGTADQVAAIVKCAAEYNLPVQSRSGGHSFANYGIGGTDGAVVVDLKHFQKFSIDNSTWQASVGSGTRLGDLTKRLGENGGRAMAYGTCPQVGVGGHALIGGLGPASRMWGALLDHVEEVEVVLANSTVVRASDKQHPDLFFAMKGAGASFGIVTEFKLRTQAAPGNAVIYTYTFQGGSTQSKADLFKRWQKLVSDPQLSRKFASQYIVAGPIGAIITGTYFGSQAEYDSLNLTSRLQTSQSNSSIEMKDWLGVVGHWSEQVAMQLVGNVPAHFYAKTLAYTKKDLMSDDTVDKVFKYIDTADKGGALFFMIWDLEGGAVNDIAKDATAYGHRDALFFHQAYAVNLLGRLNDTSRAYLNGINDVVINSRADRDQGVYPGYVDPALGANSATYYWDDNVSRLQHIKALVDPRNVFRNPQSILPAAKSVKQRAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXC3</accession>
    <name>M2SXC3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2306 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_96472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702891.1">
        <property type="nucleotide sequence ID" value="XM_007704701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXC3"/>
    <dbReference type="STRING" id="665912.M2SXC3"/>
    <dbReference type="GeneID" id="19141678"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_96472"/>
    <dbReference type="eggNOG" id="ENOG502RYBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054818_0_1_1"/>
    <dbReference type="OMA" id="RHDVWSC"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38980" checksum="84F2441BF8B79921" modified="2013-05-01" version="1">MVAQPPSTSAFARKVVNPLGFTKVYNFWLYIVFGGALTGFVLARFPYLNFSHNFCPADGPSESGNSAAPGECYYYLNFTQYKVGILLHLGGVLPASLISVTQFTPFIRHRWIIVHRIGGYAALLLYLVSLAGAFMIMRHAFGGGLEVQSVLGVLGLSTLACFIISYINVKRLQIEQHRAWMLRGWFYAGAIVTNRIILIISAQITANQGYYIVWTCAKIAVTIAPDVDLATSYPACAAYVDGTDPDAVSAVAATFGAGDAANTGAALNAGFGMALWLSLVLHAIGVEIYLHLTPREAQRLRQVSYQKQLEAGMRNPSSAGLTADRLGDAHRWSPEVPDDQHSTSSAEDVTMVSDSMVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXJ8</accession>
    <name>M2SXJ8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_173872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702860.1">
        <property type="nucleotide sequence ID" value="XM_007704670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXJ8"/>
    <dbReference type="STRING" id="665912.M2SXJ8"/>
    <dbReference type="GeneID" id="19132881"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_173872"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_1_2_1"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="305"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="393" mass="43570" checksum="1802379FA98F3120" modified="2013-05-01" version="1">MPPKKQVEEKKIPLGRPGNNLKTGIVGLANVGKSTLFQAITKCSLGNPANFPYATIDPEESRVLVPDERFDWLVEHYKPKSVVPAHLTIYDIAGLTRGASTGAGLGNAFLSHIRAVDAIFQVVRCFDDAEIIHVEGDVDPIRDLDIIAEELRLKDIEFVEKALANLVKETRRGGQSLEMKKLKEEQATVEKVLDMLKNGKDVRKGNWSPKEVEHINPLFLLSAKPVVYLVNLSEKDYIRQKNKHLPKIAEWVKTNAPGDPIIPISVQLEERIAVMSDEEAAEELKNLNTKSALPKAIQTMRKALQLGSFFTTGTDEVRQWTIRTGTKAPQAAGVIHGDFEKTFIQAIVYNYQTLREEGDEATVKAKGKIMTKGKDYVVEDGDILLIKAGAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXT9</accession>
    <name>M2SXT9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_351877</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696862.1">
        <property type="nucleotide sequence ID" value="XM_007698672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXT9"/>
    <dbReference type="STRING" id="665912.M2SXT9"/>
    <dbReference type="GeneID" id="19138123"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_351877"/>
    <dbReference type="eggNOG" id="ENOG502QPHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_3_2_1"/>
    <dbReference type="OMA" id="LTPHSCQ"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025907" description="Glucanase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD67130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="455" mass="48986" checksum="EC17B445E195EAAB" modified="2013-05-01" version="1">MSFVSVTAAFLALSAHSVSGWVIGTQQTETHPKITWQRCTGTGGTSCSNVNGEIVIDANWRWLHSTGGYTNCYTGNEWNKTACPDNAACTKNCAIEGSDYRGTYGISTSGNSLSLKFITKGQYSTNIGSRTYLMKDTNNYEMFQLIGNEFTFDVDLSQLPCGLNGALYFVSMPQKGQGTPGAKYGTGYCDAQCARDLKYIDGQANAEGWTASSSDPNAGIGKKGACCAEMDIWEANSMATALTPHSCQPEGYSVCVDDTCGGTYSLDRYAGTCDANGCDFNPYRVGVTDFYGRGKTVDTTKKMTVVTQFLGSGNKLTELKRFYVQNGKVFANPEPTVPGMKGNSITQQWCDTQKEVFQEEIYPFNKFGGMDSMGKGMALGMVLVMSLWDDHYANMLWLDGKYPVDADPAKPGVARGACEAGSGVPADVEANSPNAQVVFSNIKFGPIGSTFAQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY61</accession>
    <name>M2SY61_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_287841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696966.1">
        <property type="nucleotide sequence ID" value="XM_007698776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY61"/>
    <dbReference type="STRING" id="665912.M2SY61"/>
    <dbReference type="GeneID" id="19135913"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_287841"/>
    <dbReference type="HOGENOM" id="CLU_1015598_0_0_1"/>
    <dbReference type="OMA" id="ATHMTWI"/>
    <dbReference type="OrthoDB" id="3747338at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025437" description="Peptidase A1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="273" mass="30180" checksum="3A747E1B8440479F" modified="2013-05-01" version="1">MFNPLCLASLPVLLCQATYLDPSLLQQKPLMHGLPSDTLSDVTVLPLTLNKHLHYTFSSPTNNPTPLSRLQNSAAVHATHHEHSRISIAIPLDAAHTGTVSFSFTSSGLQDTTATHMTWIPQNPWDVDMHHIPLFDAGVRKGGMISMSVETAVLDFSSAFITLPTGLWDVIVLATQPVLKPSWGQERGQEVMSVECEARRRFPDLVFGMEDEREIVVGPKQYVLQKGDECVLLVRKAEEGDDERAVLGWAVARGREVVFDWEEGRIGLGEFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY67</accession>
    <name>M2SY67_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_29058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702549.1">
        <property type="nucleotide sequence ID" value="XM_007704359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY67"/>
    <dbReference type="GeneID" id="19135986"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_29058"/>
    <dbReference type="HOGENOM" id="CLU_1434226_0_0_1"/>
    <dbReference type="OrthoDB" id="10415171at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026243" description="UmuC domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23342" checksum="3B64A8DBE3A4BD1A" modified="2013-05-01" version="1">MAWTIDVFFEAICFYFGVLRAEEEEHWNVSTNPCNVRATDVMTAVYGFSSVMSKVLGRLNKDDVVFRGRIAAVEIESHRERIPSSAHVVVPGYERSGYKRRRTLWKSLNGDGKTLHLQGNKADSKTFASGSKTWDFCGTASRERVKRQETTSNERDEQGRCAGQEAAAGAGICIGQDSTVEIFWHMDVDCYFAQFQAMWTSKSTDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYT2</accession>
    <name>M2SYT2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_38758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702107.1">
        <property type="nucleotide sequence ID" value="XM_007703917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYT2"/>
    <dbReference type="STRING" id="665912.M2SYT2"/>
    <dbReference type="GeneID" id="19139334"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38758"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_4_1_1"/>
    <dbReference type="OMA" id="KMHPQNT"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF80">
        <property type="entry name" value="GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025470" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="674" mass="73408" checksum="5909C4CAA0433E5C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZ91</accession>
    <name>M2SZ91_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_227912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702410.1">
        <property type="nucleotide sequence ID" value="XM_007704220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZ91"/>
    <dbReference type="STRING" id="665912.M2SZ91"/>
    <dbReference type="GeneID" id="19134716"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_227912"/>
    <dbReference type="eggNOG" id="KOG3452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140672_1_0_1"/>
    <dbReference type="OMA" id="NKGHKTE"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="106" mass="12060" checksum="B5F4CCAA118D6565" modified="2013-05-01" version="1">MPKEVKQKSGLIVGINAGHKVTPRTPAPRISRRKGFLSKRTAFVREITKEVAGLAPYEKRIIELLRNSKDKRARRLAKKRLGTFGRSKRKVDEMTKVIAESRRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZK2</accession>
    <name>M2SZK2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_94418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD62907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="887" mass="99929" checksum="E5D4226DD11C876C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2B9</accession>
    <name>M2T2B9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_134538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696165.1">
        <property type="nucleotide sequence ID" value="XM_007697975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2B9"/>
    <dbReference type="STRING" id="665912.M2T2B9"/>
    <dbReference type="GeneID" id="19130933"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134538"/>
    <dbReference type="eggNOG" id="ENOG502S19W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005247_1_1_1"/>
    <dbReference type="OMA" id="YVPSEPP"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="959" mass="108726" checksum="F6CFA280AC035EA1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2E1</accession>
    <name>M2T2E1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 16">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">COCSADRAFT_38057</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701062.1">
        <property type="nucleotide sequence ID" value="XM_007702872.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2T2E1"/>
    <dbReference type="GeneID" id="19139156"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38057"/>
    <dbReference type="eggNOG" id="KOG3511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000700_0_0_1"/>
    <dbReference type="OMA" id="ATMSEFI"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025547" description="Vacuolar protein sorting/targeting protein 10" evidence="19">
        <location>
            <begin position="23"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1357"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1410"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="20">
        <location>
            <begin position="48"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="20">
        <location>
            <begin position="709"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMD63182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <end position="159"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="140"/>
            <end position="159"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63401.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="159" mass="17517" checksum="201287610FE6F879" modified="2013-05-01" version="1">MNPSERTKEALLAKTEALCKSIVDSRKDDPWGGDGYLSTILRTVKMHEATDYSSVLNKTEYEPALDYSTSAHKELLIKEQSAALIKTAQDISTLIRDLQELWLFGGLDTLADPSDEEANRKKALAVAGMIETLAKQGPTDMRKNDADLVKEESNGRGDS</sequence>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Bipolaris</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <proteinExistence type="predicted"/>
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            <begin position="1"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="859"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="887"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68805.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="102300" checksum="0F647227AFDD4367" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3P5</accession>
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        <recommendedName>
            <fullName evidence="13">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_200153</name>
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    <organism evidence="14 15">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
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        <text evidence="2">Belongs to the syntaxin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0031201">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Syntaxin"/>
    </dbReference>
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        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="239"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD63607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="388" mass="44831" checksum="BE573015D6AEA5BE" modified="2013-05-01" version="1">MWRDRTNLFISYRQSYSHHPQKKKTRYGVPGSNGFGDSRRMSEERQGLIPAFEDDGDAVIEMDLLPPRWLDMQDEVTQHLAEIAKQTRKLDQLHQKHVLPGFDDEDVKKREEREIEQITQAITRLFQKCQQAIKRIDIMVREAKQQGSINQGEEVMARNLKISLASRVGEVSAMFRKKQAAYLKKLRDLGGFTSPFRSATPVQNPYNDPALQESDADRSFSQSTLLQTKQQRMRHDPNEALIAQREREIEDIAQGIIELANIFQELQTMVIDQGSMLDRIDYNVENMFRDVKEADKELKVASGYQRRSVKRKIMLLLAILIAGVFILLSLKLSRKGGDGVSAVPKVPDVPPAAAVKSRRQSITMQTNRIWHRRKRRLWQDPIRDPLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4N4</accession>
    <name>M2T4N4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_37683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007702300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4N4"/>
    <dbReference type="STRING" id="665912.M2T4N4"/>
    <dbReference type="GeneID" id="19139050"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37683"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001528_3_3_1"/>
    <dbReference type="OMA" id="GWASNWN"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000002">
        <property type="entry name" value="Invertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026081" evidence="5">
        <location>
            <begin position="23"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="69"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="464"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="592" mass="63789" checksum="5ED987A41C0100F0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5C5</accession>
    <name>M2T5C5_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">Sister chromatid cohesion protein Dcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_211923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694882.1">
        <property type="nucleotide sequence ID" value="XM_007696692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5C5"/>
    <dbReference type="STRING" id="665912.M2T5C5"/>
    <dbReference type="GeneID" id="19134411"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_211923"/>
    <dbReference type="eggNOG" id="ENOG502SA0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054802_0_0_1"/>
    <dbReference type="OMA" id="HDYVNLC"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37015" checksum="6181F4F648BAAFE3" modified="2013-05-01" version="1">MATQHQGGLPVSIAHQQQHFRLLELPPEIVELIDKPNPPLLSIKSQASSAATGTHNAKPAYAVLCTPDKSFQVRQVQTSNSLFVTQPALEAHGNEIPIPVTRAIALCSSTLELHASSASAIALLREVLPVYDIVTGDVDATPNGMTKAGIFNDMPLSDGECQAGWGQLMAFDTDEGSYQPSPSALSHVWRSIIAAALAEGIPLDKQFMTSDIATAVAEEGHPAPLTQAVLAYLATDDTDRSGPWSCLDRAKTVAFTGKTLLDARRGDDFLIADFTDTWEDRLPEVWRKDAKLTAIEGFYEFPSDTTIKAKGKAVSAPVVDNGTTALKPSARKWHEKFAKTRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5H9</accession>
    <name>M2T5H9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pigment biosynthesis protein Ayg1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_36837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699801.1">
        <property type="nucleotide sequence ID" value="XM_007701611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5H9"/>
    <dbReference type="STRING" id="665912.M2T5H9"/>
    <dbReference type="GeneID" id="19138829"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36837"/>
    <dbReference type="eggNOG" id="ENOG502S29V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053723_1_0_1"/>
    <dbReference type="OMA" id="NDHEYPF"/>
    <dbReference type="OrthoDB" id="5409895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000145">
        <property type="entry name" value="Pigment biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45579" checksum="F6AFCD505AEAFF66" modified="2013-05-01" version="1">MPDGTWILGDLFTKEYGHRGSIQKLWEQRWKFPCTKGVYPFHDGKFEDFEPIFKHLIDNNINDPYEDAYTNAFLPTAQRLAKEAQDMETKDEEAAKKLYLNANAVYRLARFPYIGTELKKKVFEEQKKVYFRGTQLWDQPMHDINIPHKHASNGDGPEIPVYVRKPPGDGPFPTILLITGLDGHRPDNTERTQEHLNRGWATVLCDIPGTTVDCPANKRDPLSPDRLFSSILDWIAETPYLDAGKVLAWGLSAGGYYAIRLAHTHRTKLVGSVGHGAGTHHYIGREWLAQVEKHEYPFGLEEAYRQKYGYDSFEEVMEKCQDEFSLVSGKGEGVAVVGAGMASCRLLLVNGVLDGCMPVEDSMLLAEYGSPKEMRFLRERLHMGYPEANATVYPWMEGVMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5R3</accession>
    <name>M2T5R3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_326532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700303.1">
        <property type="nucleotide sequence ID" value="XM_007702113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5R3"/>
    <dbReference type="STRING" id="665912.M2T5R3"/>
    <dbReference type="GeneID" id="19136859"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_326532"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018982_2_0_1"/>
    <dbReference type="OMA" id="GMATPFH"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="183"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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        <source>
            <dbReference type="EMBL" id="EMD64671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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</entry>
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    <accession>M2T906</accession>
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        <recommendedName>
            <fullName evidence="13">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_139349</name>
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    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <reaction evidence="6">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        </reaction>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
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        <property type="entry name" value="Pre-SET_CXC"/>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
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    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SET"/>
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    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="EMD65422.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1294" mass="145530" checksum="98E3296C5E565B08" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9G1</accession>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698667.1">
        <property type="nucleotide sequence ID" value="XM_007700477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9G1"/>
    <dbReference type="STRING" id="665912.M2T9G1"/>
    <dbReference type="GeneID" id="19136294"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_307038"/>
    <dbReference type="eggNOG" id="ENOG502QVCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005319_0_0_1"/>
    <dbReference type="OMA" id="SYEDSGR"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1093" mass="118211" checksum="B1868E01B251B391" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2TB64</accession>
    <name>M2TB64_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_85148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TB64"/>
    <dbReference type="GeneID" id="19141044"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85148"/>
    <dbReference type="HOGENOM" id="CLU_206083_0_0_1"/>
    <dbReference type="OrthoDB" id="3808780at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="73" mass="8327" checksum="EEC40B0A81BAFB4D" modified="2013-05-01" version="1" fragment="single">EIVNQLTSQLMATPNEKPIRKPKMATSDKYDRSRTKLRTFLTNINLYCGYNDVPNDEKKILMANTHIKGKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDP1</accession>
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        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_288683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697038.1">
        <property type="nucleotide sequence ID" value="XM_007698848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDP1"/>
    <dbReference type="STRING" id="665912.M2TDP1"/>
    <dbReference type="GeneID" id="19135932"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_288683"/>
    <dbReference type="eggNOG" id="KOG4685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012847_1_0_1"/>
    <dbReference type="OMA" id="AFYPNNP"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="333"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD67361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="471" mass="53135" checksum="8533CBDAE87DC3F3" modified="2013-05-01" version="1">MAEAVQPVKADAAGNAHSAGATEQNQEKPSNGASRKPRPRRPNYNEIHAKPLPIDVYALPAFVPHNPISLVRLAISLLSQSLWPPKSHNVIHKVYYSVETQSIHVTDPVSIRALWEQGFWGKGSLSRSEPQWLVAEKRRRGAQASKTSTEVTQSRREERRQFKLERAKAQREAIEQQLRQEGKLVPEATVDELVDGDSKDVPTSDNVKVPAIDEATNTILAEEEEANTKLEGIDIPDLEHLQLTPEEAFFLSYVLGALDVVNVGATESDGQSESYPAWYLLRLYCAHASTPDDTADSERTLTHLHTAYSMSKAATQVDSALSCVPSIAPDNPFLLKYVVFHHFRSLGWVVRPGIKFAVDYLLYMRGPAFTHAEFAIMIIPSYSAPYWNENSGGESKIADQQRKDWWWFHRVNRVQTQVMKTLMLVYVEVPEPWDTSATELGGFKVDIGSVLKKYKVREFVFKRWSPSRNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGN1</accession>
    <name>M2TGN1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_169041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697427.1">
        <property type="nucleotide sequence ID" value="XM_007699237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGN1"/>
    <dbReference type="STRING" id="665912.M2TGN1"/>
    <dbReference type="GeneID" id="19132610"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_169041"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OMA" id="VGACHID"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD67882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="262" mass="28120" checksum="E1AB29B106663BCC" modified="2013-05-01" version="1">MLDKRMVGVVVNPGPNFSTNIEEVDIPEPGRYEILVKINASGLCCSDIGLMAEEFPVRMSTFNYRTLGYKGAGIIVKLGCNVQNLKLGDRAGIKPIRDICGACELCWGGLENYYRNAIMSGVSATGGGGVEIQCVQIVKAMGFRPVVVNSGPKKQELSLSRVADVVGICDGIGAHSVAVLAAAAYKNAVGYIGSRVRATVMSISLREDCHGTQKDAIEVLNFARRGLLQDMSEVKPLSMLPQSVKDLQAGNVPRRTVIKFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TH73</accession>
    <name>M2TH73_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate-binding module family 63 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_134455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696141.1">
        <property type="nucleotide sequence ID" value="XM_007697951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TH73"/>
    <dbReference type="GeneID" id="19130930"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134455"/>
    <dbReference type="eggNOG" id="ENOG502QVAP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026963_3_1_1"/>
    <dbReference type="OMA" id="LQVHMHG"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049818">
        <property type="entry name" value="Expansin_EXLX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041144">
        <property type="entry name" value="expansin_EXLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026451" evidence="3">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="4">
        <location>
            <begin position="100"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD68576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="285" mass="30315" checksum="D84C1D0DFCB0C889" modified="2013-05-01" version="1">MVRFTSTYTAAILALASFAAARPAERHLKGAGAHNNTPAPAASSPVASIASVPDTSSNPDNSPTSLVIPSSTASSAYTQTFNGDLTWYGKDCGEESCWQGGACAFVDYVLPATIDGSTCVSEVIWNSSYHCGACVEIDYQGKKKIAMITNKTGGDSVHLDLSPNMFSKLDNKNKGMIHSTWKYVECPIADPLQIRMHGGSSQYWFAATVVNARLHTAKLEVSGDGGNTWKPTTRNINNFFTLVGNGGTGTKTAWVRLTSDLGSQVIVKDVELVSGKTTKATANYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI24</accession>
    <name>M2TI24_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF431-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_134003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695983.1">
        <property type="nucleotide sequence ID" value="XM_007697793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TI24"/>
    <dbReference type="STRING" id="665912.M2TI24"/>
    <dbReference type="GeneID" id="19130911"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134003"/>
    <dbReference type="eggNOG" id="ENOG502RZ65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080487_0_0_1"/>
    <dbReference type="OMA" id="LEYIHIC"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22839" checksum="7BB9B52B54AD6731" modified="2013-05-01" version="1">MASTGKTFVVEHLDPELEEWSSLEYSAIAAESHASGAQFLLSSVPTSLTLPANLQGAKGLQVETRGIEEIYADKKDKVCLLDPAASKDLSPEDGDTFDIFLFGGILGDDPPRDRTSELRKKGYQGRRLGPVQMTTDTAVRVTRICVQDKVPVDQIPYIDHPDLKINKNESTQMPFRYVKGNDGQPIMPQGMRDLIVKDSAKSLNDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK20</accession>
    <name>M2TK20_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_32217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694233.1">
        <property type="nucleotide sequence ID" value="XM_007696043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TK20"/>
    <dbReference type="GeneID" id="19136691"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32217"/>
    <dbReference type="eggNOG" id="ENOG502T6UE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385859_0_0_1"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="2">
        <location>
            <begin position="588"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="80893" checksum="A208226B31DF8D86" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK21</accession>
    <name>M2TK21_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_75900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694491.1">
        <property type="nucleotide sequence ID" value="XM_007696301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TK21"/>
    <dbReference type="GeneID" id="19140533"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_75900"/>
    <dbReference type="HOGENOM" id="CLU_2764685_0_0_1"/>
    <dbReference type="OrthoDB" id="5599418at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="70" mass="7756" checksum="9E2C5F1E1AC9A28E" modified="2013-05-01" version="1" fragment="single">DHEIILNKGAKLSLGLIYPIAPEHNAKLQDYIQKNLKKGFIRLESGLIVSLILFVKKPNGSSDYMSTSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKM0</accession>
    <name>M2TKM0_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_207844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694628.1">
        <property type="nucleotide sequence ID" value="XM_007696438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKM0"/>
    <dbReference type="GeneID" id="19134351"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_207844"/>
    <dbReference type="HOGENOM" id="CLU_2704457_0_0_1"/>
    <dbReference type="OMA" id="WRYHYLS"/>
    <dbReference type="OrthoDB" id="3686616at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="85" mass="9422" checksum="8012B429E4DD149C" modified="2013-05-01" version="1">MALGAEGCQMQGRQRTFLVLSFSVPTSCGVGVSVSVSGGQMMIRPCQVNAWWRYHYLSTTIHSRGQPKQVWKGYVLSSRRLPACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKY7</accession>
    <name>M2TKY7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HbrB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_32084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694197.1">
        <property type="nucleotide sequence ID" value="XM_007696007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKY7"/>
    <dbReference type="STRING" id="665912.M2TKY7"/>
    <dbReference type="GeneID" id="19136640"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32084"/>
    <dbReference type="eggNOG" id="ENOG502RZ40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005193_1_0_1"/>
    <dbReference type="OMA" id="VELWLFT"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="91268" checksum="B9DF43CF6AFB3878" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLL1</accession>
    <name>M2TLL1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF4149 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_32675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694360.1">
        <property type="nucleotide sequence ID" value="XM_007696170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLL1"/>
    <dbReference type="GeneID" id="19136869"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32675"/>
    <dbReference type="eggNOG" id="ENOG502SF5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320942_0_0_1"/>
    <dbReference type="OMA" id="SLPMVRW"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD70041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23444" checksum="576016D181DB4B22" modified="2013-05-01" version="1">MSAEQALQILSISAALIASGGISAFSLFSIPMLKSQPASRSLPMVRWLFSRGSHIFPTAGILSSSSFFLLTYLSLPPSTPLSSFQSLFRAAVHGQPAYFLAASVLCISIAPITSFLMIPTNFTLIRMNEEMGGTRSQKSAEWRREKGGAARSADASVDGEDDVNQWKDLSPPQQKTGRESSEKEDAEVRALLDKFAWLNALRAVAIGAGGVVGLMGVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLY9</accession>
    <name>M2TLY9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_195879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695312.1">
        <property type="nucleotide sequence ID" value="XM_007697122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLY9"/>
    <dbReference type="STRING" id="665912.M2TLY9"/>
    <dbReference type="GeneID" id="19133960"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_195879"/>
    <dbReference type="eggNOG" id="ENOG502RY03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_5_2_1"/>
    <dbReference type="OMA" id="CTKANAN"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026076" description="AB hydrolase-1 domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="92"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="9">
        <location>
            <begin position="450"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD70201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="57877" checksum="E358F282091E10B3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2TMM2</accession>
    <name>M2TMM2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_32611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694341.1">
        <property type="nucleotide sequence ID" value="XM_007696151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TMM2"/>
    <dbReference type="GeneID" id="19136844"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32611"/>
    <dbReference type="HOGENOM" id="CLU_1354388_0_0_1"/>
    <dbReference type="OMA" id="QQKRGNR"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="203" mass="23036" checksum="CCB4323628CC010D" modified="2013-05-01" version="1">MAFDAYLQRADDYITKQIQKFEQQKRGNRSPPRANGYHQMSQSRQHGCMSSQGGYPGSPAPTHDRHHPPPGSMLPAGWIQNYDSHSQRWYYVDTTTGRSQWYPPSSDPQRAATFQPDTRMPNPYDQSNLRMRSNSQPQRPEMNEGGGQFLDLRQNGNAGPSPRVTSMQLSPGAHYDTKTGKVVHSMFPEGQTVQGWSQEIQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSQ3</accession>
    <name>M2QSQ3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_104437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445662">
        <property type="protein sequence ID" value="EMD58209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSQ3"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104437"/>
    <dbReference type="eggNOG" id="ENOG502SDCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175689_0_0_1"/>
    <dbReference type="OMA" id="KESHSDC"/>
    <dbReference type="OrthoDB" id="2437458at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00034">
        <property type="entry name" value="Antisense to 5.8S rRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="81" mass="9424" checksum="2981F516670EB7B2" modified="2013-05-01" version="1">MPFGIPKGAMCVQRFDDSLNSAIHTTYRISLRSSSMPEPRDPLLKVVIITFRPRSQAFIFCCVMIPPQVHLRRPCYDFYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2QT82</accession>
    <name>M2QT82_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_278734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705848.1">
        <property type="nucleotide sequence ID" value="XM_007707658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QT82"/>
    <dbReference type="GeneID" id="19135765"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_278734"/>
    <dbReference type="HOGENOM" id="CLU_1937987_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023254" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14333" checksum="9C6DEC77B9F73467" modified="2013-05-01" version="1">MPTPRRKCTLLLLADTIGVESAGPFCQTTPCSYMYLATESPWNNTCRPDMCLWHYARHEYSLGTGGSAELPLHWNKPGPAKPSVATLLMRIRNLGWDTILRGQYIVVCSSGRTVHVVLLVVVCSSRPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2QTB3</accession>
    <name>M2QTB3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_31526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705795.1">
        <property type="nucleotide sequence ID" value="XM_007707605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QTB3"/>
    <dbReference type="STRING" id="665912.M2QTB3"/>
    <dbReference type="GeneID" id="19136451"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31526"/>
    <dbReference type="eggNOG" id="ENOG502RJXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041683_0_0_1"/>
    <dbReference type="OrthoDB" id="5069333at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="512" mass="54985" checksum="70B038E633256826" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2QU14</accession>
    <name>M2QU14_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_41738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705567.1">
        <property type="nucleotide sequence ID" value="XM_007707377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QU14"/>
    <dbReference type="STRING" id="665912.M2QU14"/>
    <dbReference type="GeneID" id="19140055"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41738"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_15_0_1"/>
    <dbReference type="OMA" id="WIHFAES"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="109"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD58624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="259" mass="29287" checksum="3BC1099C5CCAF797" modified="2013-05-01" version="1">MSNQQGATITVHWLNKSRGQRIVWLLEELNLEYNIKVYKRGANRRAGPELKAVHPLGKSPVVTIRPANSEKDIVIAESETIMEYICDHFGKQLVPARYPEGQEGVLGAETEEWMRYKFLMDFTEGSLFTVLIAAILSGSIKNAPVPFFLKPITGGVAAKVDDSFVNPELKTHFDFLEDYLIRSPSKGEFFCGSSLTAADIMIHFALEGACQRVPLSDTNYPTLYKYMRRLQQMDSYKRAAKKVEDASEEKYVPFSDAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2QUV4</accession>
    <name>M2QUV4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_261653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705384.1">
        <property type="nucleotide sequence ID" value="XM_007707194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QUV4"/>
    <dbReference type="STRING" id="665912.M2QUV4"/>
    <dbReference type="GeneID" id="19135432"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_261653"/>
    <dbReference type="eggNOG" id="ENOG502SQDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021651_0_0_1"/>
    <dbReference type="OMA" id="AFMIRIP"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD58919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="536" mass="56778" checksum="F9B4F4AB5FD40EF2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2QWM2</accession>
    <name>M2QWM2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_175355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007706356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QWM2"/>
    <dbReference type="GeneID" id="19132960"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175355"/>
    <dbReference type="HOGENOM" id="CLU_1475056_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="183" mass="19135" checksum="B8FE31F1DEE45256" modified="2013-05-01" version="1">MESRFEKDAPATAEPSATINAPTALTTKPTASSTGSSLTNGQCDIGRTTYTYIHTCIHKYWSATATARFALGPGSVTAAREKAGVVARPTTAKPAISPHLTPELLPLTTSLPMLNTEAMERPARALVSVAVVQQSGSCGVAAAHCDAQRGRQAAFCDCSAGSLVHKQVGCFYLLLIIVNPVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2R1L9</accession>
    <name>M2R1L9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_29414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703038.1">
        <property type="nucleotide sequence ID" value="XM_007704848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R1L9"/>
    <dbReference type="STRING" id="665912.M2R1L9"/>
    <dbReference type="GeneID" id="19136044"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_29414"/>
    <dbReference type="eggNOG" id="ENOG502SA1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067878_0_0_1"/>
    <dbReference type="OMA" id="RNRWFPA"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="275" mass="30429" checksum="C5C7EA9EF3E35B30" modified="2013-05-01" version="1">MASMRGLALLPQCTACVRRATMQNSEAWGTQQIRSISKKAKEAERNIVVKLLKDVPRFGRAGSYVPLNPSLMRNRWFPARIADYVPATQLKQLKAQDVDMARDVTFGVRLNLEEANEEESNLMQQPKYFVRPIEIEVLSPERSMELLDTFVPPTIDFYRQPIEQDSPKRERVGASGAADILTAAAMSKAKASANAIYGSVSTADLAATIKSALAHNDEASRVVLNESDVKFVSGHEEGDASRVKQLGTFKAEIRLPGAERALVRNIRIRAKDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2R213</accession>
    <name>M2R213_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_173644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702684.1">
        <property type="nucleotide sequence ID" value="XM_007704494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R213"/>
    <dbReference type="GeneID" id="19132873"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_173644"/>
    <dbReference type="HOGENOM" id="CLU_2764656_0_0_1"/>
    <dbReference type="OrthoDB" id="10391830at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="82" mass="9091" checksum="C22BC5F0D8C25ECF" modified="2013-05-01" version="1">MAAQAQLKSALHSCFRQVHTDMCMRIRLKAPEVENNELPIDTPQPKQPREKAACISDTKTSHATLCGGDTLPTRARVVTRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8Q1</accession>
    <name>M2R8Q1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_38184</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701095.1">
        <property type="nucleotide sequence ID" value="XM_007702905.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2R8Q1"/>
    <dbReference type="GeneID" id="19139189"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38184"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="OMA" id="MNPKEFN"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="543"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="766"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
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    <sequence length="2211" mass="249059" checksum="20A37228C473A9B3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8Y3</accession>
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    </protein>
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        <name evidence="8" type="ORF">COCSADRAFT_37179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_37179"/>
    <dbReference type="eggNOG" id="KOG0825">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <location>
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            <end position="90"/>
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        </source>
    </evidence>
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        </source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
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        <subcellularLocation>
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        <text evidence="2 7">Belongs to the NSE4 family.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
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    </dbReference>
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        <location>
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            <end position="270"/>
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    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="402"/>
            <end position="489"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="307"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
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    </feature>
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        <location>
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            <end position="50"/>
        </location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD63949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="507" mass="56891" checksum="9A3982EF403A48C6" modified="2013-05-01" version="1">MARLNTHLSATPQTRASTVDSLYRDPSVAPRTEQNGRTSSYSVISPTRSMNSDKENESPATRDSTPRRGKSRGLRVVSARMPTPDSGSTDGNGSKRRRTDNYTMSRSQIYDDEQNADQDDEEDGIDTPSQSHLQPEQEEEGHLRFYNPNQDPEKRRRLRATMRDHQRMLDDNRDDLIKAHDSGLLDALRTQNSLFGKVRQTADATVDSRFLVNASDLAGKKLNNALGNHSAGIDLDQFVSKCIYFMKSGGYVAGDEDAPAMPVGDDDDDDPDGLDWAMLGRRACFPCNKRPPTASFLLGPLSVQKRIRSATQRKARSQRQPVGPATRPQEIKEGDIQQNENNNLSNLVKGIRKRLIDHTKQGADRVESELSEIPESEIDDESQNAAFRRYRMAMTTDGEPAVNLLDFAINPHDFGQTVENLFYISFLVREGNAKIVKDDDGLPLLVPAAPRGVSEQREENVQKHQAVFSLDYPTWRMFIDAYNIKEPLIPHRENEEANVGSNGWYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2RC90</accession>
    <name>M2RC90_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_160661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </evidence>
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            <dbReference type="EMBL" id="EMD64449.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="331" mass="37326" checksum="9BB87A6B163D2811" modified="2013-05-01" version="1">MLENHRYHQGTIYMIQKLVPRPASSTVRLKRMIWINQTWNRETRKVYSGKVTMDRCKSHKQQWQQGGGASSDDEEYSEKKYIRPLSTISTPPSVRWTSPSPREWLQRLSLQGDHATTPFDYSHAIRILGLGQGASRGFASSATLQVPDSSNTRGSAVWSSSETLTNQSSQERTSNYSHLRPSQPRPSSGEEDSEPRRRPTVIREEPPPVIRVSQPRSRASLTARSNFHELLSDSDPGPPYPGDRDRLPVPPPLVDDSRDPDMNLAPRIVINPSMPTRSRIPVEHSPQFRNSNEPARARTREDGGQVEHLRYATVKILLSFGGSAAVQSFVR</sequence>
</entry>
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    <accession>M2RDM9</accession>
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        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">COCSADRAFT_88204</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
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    <dbReference type="STRING" id="665912.M2RDM9"/>
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    <dbReference type="eggNOG" id="KOG2710">
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    <dbReference type="OMA" id="IIPLQHY"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
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    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="286"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD64914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1025" mass="108761" checksum="1CFFCD21D4B8219E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RDP2</accession>
    <name>M2RDP2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_116116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699459.1">
        <property type="nucleotide sequence ID" value="XM_007701269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RDP2"/>
    <dbReference type="STRING" id="665912.M2RDP2"/>
    <dbReference type="GeneID" id="19130311"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116116"/>
    <dbReference type="eggNOG" id="KOG3445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117700_1_1_1"/>
    <dbReference type="OMA" id="ISKWIDL"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="138" mass="15213" checksum="D91295CD588130CC" modified="2013-05-01" version="1">MPVAALKTVAKSQNGVGAFVLPCKSLTFHYCNWWGSSRGMNAFIKSSLPAFAKRNPQIEISVSPRPAHHPGIVANYINGAQRSICVKNLQNEGVREKAEMLRNSTGEKNRKLDGRPVKSLNESVRGIWSPFHGSKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2REP5</accession>
    <name>M2REP5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_88422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699696.1">
        <property type="nucleotide sequence ID" value="XM_007701506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2REP5"/>
    <dbReference type="STRING" id="665912.M2REP5"/>
    <dbReference type="GeneID" id="19141244"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_88422"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_4_2_1"/>
    <dbReference type="OMA" id="FAINKPC"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="479" mass="53309" checksum="8F4CB7589D29EEB8" modified="2013-05-01" version="1">MATPPKESRKKVLEGIFAVNKTQWASSAGVLRDLQEHFACSSLLAPWLENQKRSLILSHAKQKHINNLKVKLGHGGTLDPMATGVLIVGLGRGTKCLQRFLECTKTYECVVLFGAATDSYDAVGKVVSKAPYEHVTRELVEEKLAQFRGKIMQKPSVFSALKVDGKKMYEYAREGKEIPEVAARPVEVEELELVEWLEPGSHEYAWPKEEVDGVEMEGAKKLLGIREVDAKIHANTMARKGRKRSRSPEDDSVEGAGKQPKMPKSETEPAMSGALPSQETPTEAAETIQDVTPRTATDSSLPTEGKPEPSSEKAEVVNQVQSSNEDPTTSTQPPPQPPAARLRMTVTSGFYVRSLCHDLGLACSSLGLMSSLIRSRQGAYTLGQNVIELSDFESAEKWEPQLQQQLEEFMEKEGWEAEELEDDDMWQEKKKERLSERKDEDRERSYRGGGGGGKNKWNKGKGKYSRNHYSKNMDGGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2RG75</accession>
    <name>M2RG75_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_35797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698400.1">
        <property type="nucleotide sequence ID" value="XM_007700210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RG75"/>
    <dbReference type="STRING" id="665912.M2RG75"/>
    <dbReference type="GeneID" id="19138528"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35797"/>
    <dbReference type="eggNOG" id="ENOG502SANW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015530_0_0_1"/>
    <dbReference type="OMA" id="HWNLLIC"/>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="485" mass="54487" checksum="8049DDEC8C56D4BA" modified="2013-05-01" version="1">MSILNSVLGSLSPPSGFRKSFEDPHAREHELPSYNSSSPPRIPPPVTSSVLWTAPKANLPVQPRVPDDLLALQRRARHLEQQLQELLDAQADGLMAGLGAGSNVPDDLVSNGSTTPTVSSVRSSDKTAENGETLPKPRRKKAGLQAARHGISRRMKQLASIKAEELDLLDEDLRKVQNTVEKTDAWSQKRTRLEKKIREIEGQDAGAKTRSLQTEASKLEQEIRQKEEELWALKRRHRRILDELADTENSVEAKIASYKTSLSLLDREVSNFLARPVDPNHVPVSSSPYPTLPAKRRTLEMAREYWQDEYTRLAEKCEEIDADRGALDEGALLWSDVMKRVGDYETSLQNYMQQAGRKNPPEPSQLLQQMDQTISYLEEKLELASSRSWNLLVCAIGAELEAFTQGKDMLEEVLGLKRKGKEKATEPLLDQDGFQAEQPEDMTVSAIRITQSPKPPAPPKQQYFDSEDDDPDPELLVSHQDIDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2RH56</accession>
    <name>M2RH56_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_137314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697654.1">
        <property type="nucleotide sequence ID" value="XM_007699464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RH56"/>
    <dbReference type="GeneID" id="19131047"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137314"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075838_2_0_1"/>
    <dbReference type="OMA" id="HNESERH"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="176" mass="20244" checksum="0BBA3FDC9189ADCA" modified="2013-05-01" version="1">MTAIHTGYADISSRTKPYCHRCDRTFDTGRARDQHYDASARHHICDVCQFDGSSYDELVQHNRSTLHRIMCDGCDDDGWWIPDSQAYKDHLRNDNVCTTCERHFDSLNNLRHHKLVHLKPSVECYGCTRSFTTYSGMIIHLESGTCTSGIDILDLNKSAAMCYCCKLRSCRKHELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2RKN6</accession>
    <name>M2RKN6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_136018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696945.1">
        <property type="nucleotide sequence ID" value="XM_007698755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RKN6"/>
    <dbReference type="STRING" id="665912.M2RKN6"/>
    <dbReference type="GeneID" id="19130994"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_136018"/>
    <dbReference type="eggNOG" id="KOG3225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091077_1_0_1"/>
    <dbReference type="OMA" id="VNPNMAD"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD67239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="223" mass="22546" checksum="440B4F60CDEF1B12" modified="2013-05-01" version="1">MAFPGGPGAMPASMNPTAGMSEQEQQMVKAMQMGMESCLGKTVMAGVMGGGLGAMFGLFMSSMRYDTPMSQPLPMNTPTTPAPSTSTAAGVKPSTVASSASSSSAAAALPNLTAAGTVPITDLPLKQQLRAGLRDMYRSSISSGKNFAKVGAIFSGTECAIEGLRAKNDLYNGVAGGCITGGILARNAGPQAVAVGCAGFAVFSAAIDAYMRMPEDEKSKPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RMR8</accession>
    <name>M2RMR8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_156400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695679.1">
        <property type="nucleotide sequence ID" value="XM_007697489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RMR8"/>
    <dbReference type="STRING" id="665912.M2RMR8"/>
    <dbReference type="GeneID" id="19131760"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156400"/>
    <dbReference type="eggNOG" id="ENOG502S0AD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003318_1_0_1"/>
    <dbReference type="OMA" id="PVPKWAQ"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1058"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="627"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1118"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="834"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="894"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="926"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1008"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1061"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1136"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1157"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1170" mass="128442" checksum="2622DD0A11954091" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2RMV7</accession>
    <name>M2RMV7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_187007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
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        <property type="entry name" value="5'-nuclease"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XPGRADSUPER"/>
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        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PIN domain-like"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="625"/>
        </location>
    </feature>
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        <location>
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            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="901"/>
            <end position="923"/>
        </location>
    </feature>
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        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="847"/>
            <end position="862"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00485"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD67964.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="102905" checksum="3BFD5B727700DD9C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQG1</accession>
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        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_109777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007698133.1"/>
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    <dbReference type="AlphaFoldDB" id="M2RQG1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="659"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="778"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="970"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="787"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="970"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="992" mass="110699" checksum="72FDDAEDD0F3F3D5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQH1</accession>
    <name>M2RQH1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_33682</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695602.1">
        <property type="nucleotide sequence ID" value="XM_007697412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQH1"/>
    <dbReference type="GeneID" id="19137261"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33682"/>
    <dbReference type="eggNOG" id="ENOG502RXMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_0_0_1"/>
    <dbReference type="OMA" id="YIDSPPN"/>
    <dbReference type="OrthoDB" id="5558646at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024247" description="AA9 family lytic polysaccharide monooxygenase" evidence="17">
        <location>
            <begin position="17"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="239"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMD68819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="350" mass="35457" checksum="D25F87E1806EBFE2" modified="2013-05-01" version="1">MKSFISALAFAGAASAHCTIWGVSVNNKDLGYGNSQGGYIDTPPNNSPVTDVTSKAMECNVANIKASKSISINPGDEVAVQWFHNGPGAGDQIIDGSHKGPINVYMSKAGSSMSWTKIAEDGWDGKSWAVTKLRDGAYNGKKGQHTFKMPNVAAGDYIIRPEIIALHEGNRPSGAQFYMGCIHVKVGGSASGSLPAGVSIPGYVTATNPGVLFNIYGSFQNYPNPGPKLWSGAGTATAADAAPAPAPAAGAPAASPSPATGAPSTEAPSSEAPAAEEPEECTDDTAEPADEPAAPAPAAPAASAPAAAPATGGAEAQKWHQCGGQGYTGATACVSGTSCVKQNDYYHQCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRJ3</accession>
    <name>M2RRJ3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_207264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694589.1">
        <property type="nucleotide sequence ID" value="XM_007696399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RRJ3"/>
    <dbReference type="GeneID" id="19134344"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_207264"/>
    <dbReference type="HOGENOM" id="CLU_2413094_0_0_1"/>
    <dbReference type="OMA" id="WWLALDC"/>
    <dbReference type="OrthoDB" id="3691597at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="93" mass="10612" checksum="81A4A9C34C4DACC4" modified="2013-05-01" version="1">MRFCILYCFARSTPHCRPRYSAKCRPISRMPPKVHGGPDADKSPPWWLALDCFGAPWPCLTRFRSLNVPSFWRDDGRPSHMACDGSNCPALLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RS70</accession>
    <name>M2RS70_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_32154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694216.1">
        <property type="nucleotide sequence ID" value="XM_007696026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RS70"/>
    <dbReference type="GeneID" id="19136662"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32154"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_0_1"/>
    <dbReference type="OMA" id="GLYPCML"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32647" checksum="3553FD3A85758552" modified="2013-05-01" version="1">MPTKVALITGGASGIGFATAKALSNHSSENWDIHIVDQNAEAGKKAASELKNAFFHQADVTSYQSLISAFEVTWSNAERLDFVFANAGIVERDNFYAKHDLNGPPPPPPNKFSTDINYKAVVDTSYLALHYFRKTNARNEGDELDPVLIMTSSCGGLYPSEFCPIYSGSKAGLILFNRAIAVAYHNEGIRTSTICPGTIKTALMSEEEWKFFPVEYFTPVETVADTVMKLVEGAEMKDAKGITKSKNKIWGLTVEVNGRNFYFRDGPEYCDDNMKKMMTNTSMTKQLARIEGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2RX99</accession>
    <name>M2RX99_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_252543</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704674.1">
        <property type="nucleotide sequence ID" value="XM_007706484.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2RX99"/>
    <dbReference type="GeneID" id="19135249"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_252543"/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702228.1">
        <property type="nucleotide sequence ID" value="XM_007704038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S3R7"/>
    <dbReference type="STRING" id="665912.M2S3R7"/>
    <dbReference type="GeneID" id="19141630"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95625"/>
    <dbReference type="eggNOG" id="ENOG502SCYV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072332_5_0_1"/>
    <dbReference type="OMA" id="TSYLIFW"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD61833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="120" mass="13238" checksum="75F8FA3F22409C17" modified="2013-05-01" version="1" fragment="single">IVVYDAVLSPVYQVPVLYFGIQDSLHRYPPTMATLYDHLVMPHFRPQTQDTNTGVIGGISMAEHPITNTPVFFIHPCQTAQVMQASLHKDTTAEAYLIAWIGALGKPVGLNIPLLLAQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8K4</accession>
    <name>M2S8K4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_31072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705197.1">
        <property type="nucleotide sequence ID" value="XM_007707007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8K4"/>
    <dbReference type="GeneID" id="19136375"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31072"/>
    <dbReference type="HOGENOM" id="CLU_2223054_0_0_1"/>
    <dbReference type="OrthoDB" id="10323554at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="106" mass="11640" checksum="7C36F72A2C489839" modified="2013-05-01" version="1">MSNRLVALVSPLDLNTLQFITLLVQSNWPPSTGATVQLGRQITSSGQVLYKAVVTNCAGGNMYGNINLLTDIVVGHSRGEALYRLLEHVEVQGWRRIMEADMGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8X1</accession>
    <name>M2S8X1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial uncoupling protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_331679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700799.1">
        <property type="nucleotide sequence ID" value="XM_007702609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8X1"/>
    <dbReference type="STRING" id="665912.M2S8X1"/>
    <dbReference type="GeneID" id="19137067"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_331679"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_0_1"/>
    <dbReference type="OMA" id="KDWYKGG"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD63788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34548" checksum="5369D8B162EF2812" modified="2013-05-01" version="1">MSAKSVQGPNGKKPASAATNLIAGGGAGMMEALACHPLDTIKVRMQLSRRARAPGAKKRGFITTGAEIVKRETALGLYKGLGAVLTGIVPKMAIRFTSYEWYKQLLADKDGNVASKSTFMAGLAAGITEAVLVVTPMEVVKIRLQAQHHSMADPLDVPKYRNAAHAMYTVVKEEGAGALWRGVSLTALRQGTNQAANFTAYSELRAQLQNYHGSTDIPSYQTSMIGLISGAVGPFTNAPIDTIKTRLQKTPAEAGQSALQRITNIAGDMWKQEGVRSFYKGITPRVMRVAPGQAVTFTVYEYLKGVLERGREMLPGGQYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2S9X9</accession>
    <name>M2S9X9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_101896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705080.1">
        <property type="nucleotide sequence ID" value="XM_007706890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S9X9"/>
    <dbReference type="STRING" id="665912.M2S9X9"/>
    <dbReference type="GeneID" id="19129766"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_101896"/>
    <dbReference type="eggNOG" id="ENOG502SI6P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008719_1_3_1"/>
    <dbReference type="OMA" id="VQHHILA"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54585" checksum="F22280E08AF38B0F" modified="2013-05-01" version="1">MECAIVQFLDESPEIRSHYVQNGDSPFSGSSVLYQSPGPSASGQDNSNLTAGSTLFTPTEGLTVLSLLNSESPVQRNTSAPSMTPDQPPNTSAYQRHDNANASTFVYQQPPGEPVLWPLEHEQEAMLLQHYIENVALFFDMMDSRDHFGVHIVQMAKQNSTLMNAILALSARQLSRIADFDPYIADAYYQRCFDTLIPALNDNSTIKEEPLLAATVILRLLEEMNISVVGSDPQGHLFGTQAIIRAAEQSYAATSGPDWRQAIYWAAFRQELWISLMTQKAFKLHIFPADRSLEPATDSMWATRTIAHLGDVSNFVFGEDRNSIARYNQLMDENKAWNQCRPNSFDPYYFRHKNPSSGNSFPDIRLHRKEHVMGMQYNLLAHTLLIVHDPTIPQLGPAHKASRAVVDKAVQENVRIMCGVAQSNPKVFPCIFVACYAIALVGDRFTIREEQQSLRDLWYSCEQTHAFPPTAMIAQLEESWGWHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAY3</accession>
    <name>M2SAY3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI transamidase component GPI16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_143044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700254.1">
        <property type="nucleotide sequence ID" value="XM_007702064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SAY3"/>
    <dbReference type="STRING" id="665912.M2SAY3"/>
    <dbReference type="GeneID" id="19131266"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_143044"/>
    <dbReference type="eggNOG" id="KOG2407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021459_2_1_1"/>
    <dbReference type="OMA" id="NHGHYIG"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025422" description="GPI transamidase component GPI16" evidence="2">
        <location>
            <begin position="20"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65041" checksum="7E2C11275C4327D2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB00</accession>
    <name>M2SB00_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_40835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="P:base-excision repair, AP site formation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000010">
        <property type="entry name" value="G/U mismatch-specific DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
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        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
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    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
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        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
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    </dbReference>
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        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
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        <property type="entry name" value="UDG"/>
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        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="117"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD59660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="329" mass="36371" checksum="E0A3ACF8C9B751D2" modified="2013-05-01" version="1">MPQTRLGKSRNQNDKVPQHVLSDGDGPEPNDIPATPPSAPFKDQLSNYAYKEQDVTSNEVSTSTNSNRPRKRPRTATIAAVGSARGSTQQPTKKRKAGQYALPSKYAHLSPLVDILEPNLICVFVGTNPGVQTATAGHAYAHPSNHFWKLLHASGLTNRRLKPEEDRSLPGLFCMGNTNIVDRPSKNAAELSKEEMSAGTASLDAKFLKYKPEAVCIVGKGIWEAIWRYRYGKNPGKNEFKYGWQDEKHNMGKCPEDGEQELDANGNPWKGTKVFVTTSTSGLAASLTPAEKEAIWRPFGEWVQKRREERGFVPRLVEAQSAVEETAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBL7</accession>
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        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">COCSADRAFT_189750</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_189750"/>
    <dbReference type="eggNOG" id="ENOG502T125">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164942_0_0_1"/>
    <dbReference type="OMA" id="EWTFDIL"/>
    <dbReference type="OrthoDB" id="5235486at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012429508" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12883" checksum="6B5A55D9EB15BE66" modified="2013-05-01" version="1">MKFLAAATLFGFAAAAVETVTISHFLYVGVNGYPQISFKLSVDGVSCAADHYTVDSLGNPCDKPEWTFDILEEQGRKIRLHHTVDGVTHTGDFAIGLNGPIPTVLEQIGTSTADLDRITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBP0</accession>
    <name>M2SBP0_COCSN</name>
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        <recommendedName>
            <fullName evidence="12">Purine-cytosine permease FCY21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_99673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704195.1">
        <property type="nucleotide sequence ID" value="XM_007706005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBP0"/>
    <dbReference type="GeneID" id="19141870"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99673"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_0_1"/>
    <dbReference type="OMA" id="ARWGWET"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD59910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55441" checksum="AB6B005DA8DD1223" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCC1</accession>
    <name>M2SCC1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">COCSADRAFT_116176</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699486.1">
        <property type="nucleotide sequence ID" value="XM_007701296.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SCC1"/>
    <dbReference type="GeneID" id="19130313"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116176"/>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_8_2_1"/>
    <dbReference type="OMA" id="HACSVIR"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000034">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1831"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2551"/>
            <end position="2862"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="2901"/>
            <end position="2933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2831"/>
            <end position="2862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2870"/>
            <end position="2889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="2834"/>
            <end position="2850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="2874"/>
            <end position="2884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EMD64953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2933" mass="328744" checksum="40C3436228126490" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40602</name>
    </gene>
    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="19139788"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40602"/>
    <dbReference type="eggNOG" id="ENOG502QRB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SUR7_domain"/>
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    </dbReference>
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    </feature>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
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    </evidence>
    <sequence length="307" mass="34549" checksum="1C105501DAF927EE" modified="2013-05-01" version="1">MPFFSRNRASENTTATPVPELSKEQIKLATRRRKRWALATSFFLFLTFIFLVLVNIAGVRNKPVIRNWYFIRLDLSKIVPASVPNFALINTIAQTLGLHDFYQVGLWGFCSGYKGQGVTFCSKPTTLYWFNPVEILRNELLAGASINLPANINDILDLIHLVSNWMFGLFLTATVLSFVLIFVMPISVYTRWLTLPVAILAFLNALFVTVASVIATVMFVIFHNTITGVSELNIGADIGTTLFAFMWVASAFAIFAWLVQTGLCCCCASRRDVKKGKKRGNEEAYQMDAAPVTEKAPKKKYEFWKRG</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
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    <dbReference type="OMA" id="HANAKAH"/>
    <dbReference type="Proteomes" id="UP000016934">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="204"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60370.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="218" mass="24251" checksum="3EED3D8EF67F037C" modified="2013-05-01" version="1">MSSYDSNKSNYLHTQYQQHPQAPPYPTTPNAPQSPSYFSQMPQQQSQQMYSSSPPYTQPSFPHQQSQHQQTRHTRTSSTSSMSHSYPPPPGPPPASHSGQQPIGIPIHQPTPHHYHPYASSYPPPPAPPTSTNYTPHARSMSTYSHHHEDEHGSRYGNGNGNGNRDGNGNGELDSETEREYKRRYAREKRVERRPTLGGSLLSMVDAVGKAFGGAGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SD34</accession>
    <name>M2SD34_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_40040</name>
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    <organism evidence="9 10">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
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        </reaction>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
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        </reaction>
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    <comment type="catalytic activity">
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        </reaction>
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        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_162942</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="388" mass="42326" checksum="87FFB5735DEE9F2F" modified="2013-05-01" version="1">MPRRFINSITADPAPAKSLVLPLTLALTLADTTPLDMAVSTSHTAPERGGLQETAKRLAKVEMRLSTLLFLVPLASARVIRQAQQIPIVDNAADDTTSVEDNTTHASPSIGLHFTTSHAVAAAHYQNGTTRDLVRMEGGADYQDLMRRWLSSSSGYSGPLEPSDEMVLSGFMIRLHRAIETELDDSVQKAALALSPQAPKLQRNFQKAMVAAGLASSEDSAVLYEEAMATHAALKPASSCTTQSQSEHLQHVLFLAFDDGAFSVSMHEYACRDYTSQGHIINRIIRSDLGWWHLPMYDAPRARFWAQVQQSIGFVLSPQGKAPGRIVLLGSHGADAEFKSRVEDALWDELEMDVSGMLSVNERGDSEWLAARGAAELASRHSEKKYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHF7</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61850.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SHF7"/>
    <dbReference type="GeneID" id="19139307"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38653"/>
    <dbReference type="eggNOG" id="ENOG502R8AI">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1447559_0_0_1"/>
    <dbReference type="OMA" id="KMNKRTR"/>
    <dbReference type="OrthoDB" id="3800694at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="187" mass="20726" checksum="F61F915D961626D3" modified="2013-05-01" version="1">MAANTGFRLGEDQFSEASDSDQSQHSQRSPSPRQANGQVPAQKSKKKKQKDRRKMGALADELVDVLDDAFSAPTAHAYTGTDQQTSGDQSIMVDAESAGKKMNKRTRQNLARMQARKERNSVKMKDVTQDKTLQAEMAAAERRGMSLEEYRKLGSGKGMSKASARRVKKEAMRKQRVAAMVDEMEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJ17</accession>
    <name>M2SJ17_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_34039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696522.1">
        <property type="nucleotide sequence ID" value="XM_007698332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJ17"/>
    <dbReference type="STRING" id="665912.M2SJ17"/>
    <dbReference type="GeneID" id="19137414"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34039"/>
    <dbReference type="eggNOG" id="KOG2086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029402_4_1_1"/>
    <dbReference type="OMA" id="NKDHTDK"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000179">
        <property type="entry name" value="Plant UBX domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SEP" evidence="4">
        <location>
            <begin position="236"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="356"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="45947" checksum="544E7B57B4EB30AD" modified="2013-05-01" version="1">MSEAATDRDAQVAQLASLTGLDAATAERYLNASNGDLTLAASLFFDQTAEQQEADSEPDVDMAGDDDSTTNPSQNPPPPSGGGRTLGGDYVPSSAAAAAASSSSSSSQRPAGRGQPAQRGVAGARTLRDLQSSGGGQGQAHDDEDDDHSPEDDSQDFFAGGEKSGLAVQNPNQSNPRDQINNILKRARQNAPRPGGDDEQPASSHFRGAGTTLGGDDAPSRVIPDPNSNMPAPPPRAHRELHLWRDGFSVDDGDLFRYDDPANARTLEMINTGHAPLHILNVEHGQEVDVEVHAHKDEDYKKPKKKYVPFSGSGNRLGSPTPGSSSTAATMPAAGSSSTGASTSGGSAQPSVEVDSSMPTLTLQVRLGDGTRLTSRFNTTHTIGDVYDFVTRASTASQGREWALMTTFPNKELTDKGQVLGDIAEFKRGGVVVQKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJ49</accession>
    <name>M2SJ49_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_34071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696533.1">
        <property type="nucleotide sequence ID" value="XM_007698343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJ49"/>
    <dbReference type="STRING" id="665912.M2SJ49"/>
    <dbReference type="GeneID" id="19137434"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34071"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049047_3_0_1"/>
    <dbReference type="OMA" id="FKMWFFF"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD67218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31518" checksum="98A7A81AAE5D01C5" modified="2013-05-01" version="1">MFFISAIVKNIAPIFIATSPITSYGDQIYSMHRARSSAGFSLDIPLIMLVASILKVYYWFGAHFSTSLLIQAILMICVHLLLLHVALTNRPPPSHLPFQHNDVSSRPYDFWQWRAPRPYWAFITYFAGSLLVLHLLMSSTAVFGPYTDLLGGIALTIEATLPLPQILANWQRRGCKGFRPSVIVNWVIGDTFKMWFFFASSSGEVPWAFKACGIFQACCDLGLAAQYLVWGDGPAGVEGLGREKELRSPVPGDVDWNVEKLGQASVTGGIEMSDAQAWERPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLB5</accession>
    <name>M2SLB5_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_267217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697519.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SH37">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="33"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24058" checksum="DED2BDA16F982B50" modified="2013-05-01" version="1">MEQGKGLWKKRILVPFWIVRICLMIFIIAIFAYTLRTLKDLKDFTEPGPGTVVLFILFMVIVLLIDVLAILLFLRDKLKPGTFLTMNCFQTGFWAGVLIVDFVAIGHGVSPVGIGFSIFVFLTFLGLLIYSIIGHRRAKAAAQRGHYAPAHNPALPATDLHGTPYFGAPDNHQNTAYHSQTHPPPDAHDQYAAPPSYQAGAAGDYYQQQPMKPAHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLW8</accession>
    <name>M2SLW8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_167424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695845.1">
        <property type="nucleotide sequence ID" value="XM_007697655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SLW8"/>
    <dbReference type="STRING" id="665912.M2SLW8"/>
    <dbReference type="GeneID" id="19132515"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167424"/>
    <dbReference type="eggNOG" id="KOG4763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_829405_0_0_1"/>
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    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="11">
        <location>
            <begin position="261"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD68163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="328" mass="35299" checksum="7DB57F1C48FD4224" modified="2013-05-01" version="1">MIPKATKSFPTPSQMPGNIPASNLSDSKPYADYTENGTIVVISQPSGQSCAVVGGIMAARMQHLGAEGIVVDGRVRDISALNQTKLPIWSKATSVIGAGAETKFHAHNVPVKIGETIVEAGDIIMIDPFENGVVAVPQAKVDELLELLPKLVEADEKVTADVGNGVSVEEAFKRHRAFTMGITDFFSDVWETFSHPSADAEHPVQGGTSTKSPASGTDEESGDEAEVNKQDAKSGGSDEQGHKPSEESEEDEDEEEEEEPDPKDTLEKECAESKECHGPKHHYDECAQRVTGQIEEKGKADEDCVEEFFHLAHCATQCAAPKLFAQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN95</accession>
    <name>M2SN95_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_33504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007697372.1"/>
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    <dbReference type="STRING" id="665912.M2SN95"/>
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    <dbReference type="eggNOG" id="KOG0154">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007254_1_0_1"/>
    <dbReference type="OMA" id="TEWQHRS"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
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        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
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        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="615"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="751"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="707"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
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            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
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            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="794" mass="87356" checksum="FB5E42CA09108724" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNP2</accession>
    <name>M2SNP2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_187661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNP2"/>
    <dbReference type="STRING" id="665912.M2SNP2"/>
    <dbReference type="GeneID" id="19133597"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_187661"/>
    <dbReference type="eggNOG" id="ENOG502SIMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_7_1"/>
    <dbReference type="OMA" id="RFAYWYF"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7708" evidence="3">
        <location>
            <begin position="76"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="288"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD68803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1171" mass="133436" checksum="FA4355CAA0E5FE99" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP73</accession>
    <name>M2SP73_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_36661</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699761.1">
        <property type="nucleotide sequence ID" value="XM_007701571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP73"/>
    <dbReference type="STRING" id="665912.M2SP73"/>
    <dbReference type="GeneID" id="19138789"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36661"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="OMA" id="DIERNAC"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="18">
        <location>
            <begin position="70"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="19">
        <location>
            <begin position="411"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD64080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="605" mass="64720" checksum="31D78538CF266895" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPE1</accession>
    <name>M2SPE1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_41567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
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                <person name="Grimwood J."/>
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                <person name="Han J."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Dhillon B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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        <text evidence="1">Belongs to the HIT family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694083.1">
        <property type="nucleotide sequence ID" value="XM_007695893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRD8"/>
    <dbReference type="STRING" id="665912.M2SRD8"/>
    <dbReference type="GeneID" id="19134567"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_22003"/>
    <dbReference type="eggNOG" id="KOG3969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041045_0_0_1"/>
    <dbReference type="OMA" id="HVHINPI"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000016">
        <property type="entry name" value="Scavenger mRNA decapping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37867" checksum="2557D711469F7AC2" modified="2013-05-01" version="1">MTSTTPPEVAAHVESLIPKFKLTRLLNSDQAGRRISLLGIIDSQPALLIAERAAFDTTPAILEGFSTSLRNIKNLGANDIYAWFLANSSPSSDKDASSPPPPDFKINLIYPCTDKHVKKYTQQRLRIVTETPEIYTSYIRPYMRAQREKGALNWVYNIIEGRTEQEDVMYRESGSDGFLLLPDLNWDRKTMGSLHLLGIVERRDIWSVRDLTTEMVGWVRHMTEKMVEATVGLYPEIERDELKLYVHYQPTYYHFHIHIVHVSLEAGNTQATGKALGLENIISQLETMAPSLSSSGLPPGMQDASLTYHLGEQSDLWEKVYLPLKEGRGVNVDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS69</accession>
    <name>M2SS69_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_199303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GcvT family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699603.1">
        <property type="nucleotide sequence ID" value="XM_007701413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS69"/>
    <dbReference type="STRING" id="665912.M2SS69"/>
    <dbReference type="GeneID" id="19134091"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_199303"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_11_2_1"/>
    <dbReference type="OMA" id="MVFKYDQ"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="655"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116778" checksum="4F037E85860138A7" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSF8</accession>
    <name>M2SSF8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_175111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51543" checksum="0CC1998FA2C949B8" modified="2013-05-01" version="1">MAVLSLVSATTVAYLSLSFVAYWIIYCRTLHPLARVPVYRMLRGGLEVAQNKLHKKYGQLIGIVPEEVSCADASVIPLIYSSHSPLPKTDWYHIFTPTGLGENADLFSKTNEEKHTKHHKIVSPAYQMSSALRNETAIDECITLFTKRMRELAAKKEAINLGSFLNFYAHDVIGFVLFGHRFGYLEAGGDVGSFLNALDKAVPFIYVIAAVPNYIRKVLMFLSIFIPGTVGHLQAIQAISDAAKEQTQLRMERSTQEKNLQLRIVETGGADKGFTHRDVTLESWAGLMAGSDSINPHCIRLVVQEIKSQEHVLSTPVTYNETVKHLPYFGACIKEALRLFPTVGFSLPRVSPPQGILLKGQRIPAGYVVGVNPHTIQYNPEVFGNDATEFRPERWLESQAMNFEMICVGKDIALVEMYKFIPEILRNFEIHMAHDGPLKTWNAVFIRQHCLITRIAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSU3</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSU3"/>
    <dbReference type="STRING" id="665912.M2SSU3"/>
    <dbReference type="GeneID" id="19140342"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_57585"/>
    <dbReference type="HOGENOM" id="CLU_2190109_0_0_1"/>
    <dbReference type="OMA" id="YGHIRRI"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="110" mass="12693" checksum="769DE5EB2EEFF74E" modified="2013-05-01" version="1" fragment="single">EEDIPLLNLDLLSIKPADRQWFTDVNIAVRDLSKGSETQNNYGHIRRIVSNAAHILDKEVKHHEWARKLDPLIIWVSCMVYSVSRQLCRAAEKPCDQLDVIDDFLKSYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST94</accession>
    <name>M2ST94_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_203034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704251.1">
        <property type="nucleotide sequence ID" value="XM_007706061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2ST94"/>
    <dbReference type="GeneID" id="19134244"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_203034"/>
    <dbReference type="eggNOG" id="ENOG502SAM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607118_0_0_1"/>
    <dbReference type="OMA" id="DSWGNFV"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50893" checksum="719CD26CBAC0E4C5" modified="2013-05-01" version="1">MVNAKYVAFTVNKQTPFLQTPDQAYATVINCRPPAGKRAAFAQEVRSHNVPLAKVEGSLKRKRGEDSKREYDQAAHSSASYASNAMAPLATATARPLLTQQWQQRKPTRLRRGKVLSKGVDLDCWFIILSYSDPAQLLEMRSKIASCYRFLRDNPMLWKHSRVYYYGTDMPDPPPGLTEFQFAHLRHGHGCMDCGAPNTRKTFWAFLRRMCKDCLTNQVIKEYEAIALLKGPDGEDISFIRAALPSGIYDSWGNFVGVGPASTHALKTIYLRSDVDKLVAEYNRELRERAPDANESPAWIAAWLASKAQRIEERQAFAKKMEQWEEMQRTARTAEYSSKKSRRKAYFKEKAAQLSPPIGIKELEACPSYKRAVTIPKDPNNTSWDLLKPKIVKEAAEIAARRSLEESHPPTASSSGISTPTSSMTGYPHAHLYLGTIMGLPPPDHHHHMFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2STC7</accession>
    <name>M2STC7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_241827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703725.1">
        <property type="nucleotide sequence ID" value="XM_007705535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STC7"/>
    <dbReference type="GeneID" id="19135023"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_241827"/>
    <dbReference type="HOGENOM" id="CLU_2291467_0_0_1"/>
    <dbReference type="OrthoDB" id="3690239at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="101" mass="11061" checksum="72D88DE57E6E5DE7" modified="2013-05-01" version="1">MVAEKALVGTSTVATWRSGVQSTFSLSITIHILCPRFKPSQRYSRYMAFPFGDLGGNGFLKLTLYITVTDASTCARLCKSKKGISGCRTIYPRSAARGRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2STK3</accession>
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        <recommendedName>
            <fullName evidence="4 13">Glycerol-3-phosphate dehydrogenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_126343</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 13"/>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704315.1">
        <property type="nucleotide sequence ID" value="XM_007706125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STK3"/>
    <dbReference type="STRING" id="665912.M2STK3"/>
    <dbReference type="GeneID" id="19130654"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_126343"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_1"/>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="16">
        <location>
            <begin position="106"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="17">
        <location>
            <begin position="519"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="685"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD60092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="722" mass="79430" checksum="D4F643C4171D4F69" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU69</accession>
    <name>M2SU69_COCSN</name>
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        <recommendedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_184175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007705531.1"/>
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    <dbReference type="STRING" id="665912.M2SU69"/>
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    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Lag1/Lac1-like"/>
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        <property type="entry name" value="TLC-dom"/>
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        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="EMD60342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="491" mass="56077" checksum="F1AF6BE229B91EFD" modified="2013-05-01" version="1">MAAKATMPPAIGTPQKSHTANIQAEKAPTAPKKRKMQPKKADDEGLLATLCTLISDHQIGISVNLLTLLTLTHFFFPRARSRTNKFFHMSYYNSETGMYGCGTDDLPFVFLWTIIFTGLRVAVMEYMLNPLARLGGIRTKKGLSRFKEQAWLIVYYTCSWSLGMYIMYHSEFWLNLHGIWEGWPFREADGLFKWYYLVQWGFWIQQILVVNIEEKRKDYAQMLSHHLFTTALMALSYGYFHMRVGIVILTIMDFVDIVLPTAKLLKYMGYTNACDYVFGLFVISWIVTRHVLYMMVCWSIYVYAPLDMEPGCYLADSTSKQTSFVPISNTSQFEALGGNNHWGNLLKAYNDRNGPICWNPQIRYYFLALLLTLQVFCCIWFATISRIVYTVVRGNAAEDLRSDDEGEDEEIEEDQTNTIFNMATTCAESGMSSLQPKEEEVGVDALTFARMNGASQRRQARRESARASGISIPGHGDRKELLGRIGCDKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUU0</accession>
    <name>M2SUU0_COCSN</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_97810</name>
    </gene>
    <organism evidence="8 9">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUU0"/>
    <dbReference type="GeneID" id="19141755"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_97810"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="HPVAYFM"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="221"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="26"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="543" mass="58818" checksum="CD64C9C1FE98499D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVD7</accession>
    <name>M2SVD7_COCSN</name>
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        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">COCSADRAFT_29301</name>
    </gene>
    <organism evidence="8 9">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
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            <end position="365"/>
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    </feature>
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        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD61011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="883" mass="100207" checksum="AEEA044CC9FDB321" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SW51"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_97244"/>
    <dbReference type="eggNOG" id="ENOG502S88K">
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    <dbReference type="OMA" id="RFAAFKY"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
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    </dbReference>
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        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="122" mass="13692" checksum="3A5FF4F0A55DE784" modified="2013-05-01" version="1">MATQSASTSSPVTRIATFRFRDEVTPAQKGDRTAAFLALYSEHPELLVEGPKGGRPLNTPLNLTNVKRESVWDTGFVVVFKDEAARQKFDLDPGHDRLKEETDPLLEQVFVYDFVAQPNLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SW73</accession>
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        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_97096</name>
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    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SW73"/>
    <dbReference type="STRING" id="665912.M2SW73"/>
    <dbReference type="GeneID" id="19141721"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_97096"/>
    <dbReference type="eggNOG" id="ENOG502S3EX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019274_0_0_1"/>
    <dbReference type="OMA" id="EYGMQKQ"/>
    <dbReference type="OrthoDB" id="5400327at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="19135897"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_28661"/>
    <dbReference type="HOGENOM" id="CLU_138652_0_0_1"/>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61296.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="162" mass="17542" checksum="DD84E7997E944EDA" modified="2013-05-01" version="1">MRLQLFCLTARMGLARRIRLRFRGRVHVVVVVVRCGGDEHSPPFAGGGAKLGTGCPIRAVHEITCASQIRNGWPLVNASHPLRAGVVVVVGGGVPQNTETRLDSKGDAVRLRALQSVSRPHPLTTSTPTTAHVKLEPERATHARLIRLMPTVHLHAGSRLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWB7</accession>
    <name>M2SWB7_COCSN</name>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_239428</name>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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        <source>
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    <sequence length="415" mass="47135" checksum="880AB3C3611BE184" modified="2013-05-01" version="1">MGKPVPPPPSYRDDPEAVSLRTTPDDYAYTDLPEPSGLPPSYSESESSNHVPASAIPIRHVAPPSTRTNHDRPSFKCGKPCVVETVDVTEPAYDTDPAQLEEAIRAYANSAPVPLVYIRGTHKETVRKNDNKRETHHVTDFRIVINLQHYLHPNFNPSDTSPMSLVTVSNGEKTHRGTILAHRAPGVKSDVEIGTTRAPSLTEWCHRYCASPRMLRIFRLRRQITGFEETQLRNRIVGLLRSTNYRGNISVTFPVEEANIDIYTSNRINTLRLKTWVCWLFYLSFLWIFSWPMLFFATRRYAVVRAEWPFSTTDERGEKRYTTVSEEQWFETWKVAIRRLALERFEGEATEDMMRRVMARDEDPQMPMGDAGVDGALSLLSEGVRVVRAMQGGHGVDLSFGRGRSVQGGGWGYDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
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        <name evidence="14" type="ORF">COCSADRAFT_82804</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">ND90Pr / ATCC 201652</strain>
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    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD67180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1653" mass="185446" checksum="0F1CB3EE995C998C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY71</accession>
    <name>M2SY71_COCSN</name>
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        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_39456</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702652.1">
        <property type="nucleotide sequence ID" value="XM_007704462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY71"/>
    <dbReference type="STRING" id="665912.M2SY71"/>
    <dbReference type="GeneID" id="19139500"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39456"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_5_0_1"/>
    <dbReference type="OMA" id="GQVMRNN"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="17">
        <location>
            <begin position="87"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="18">
        <location>
            <begin position="523"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMD61752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="990" mass="112092" checksum="D0C677034C7529EA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZZ3</accession>
    <name>M2SZZ3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_32865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695388.1">
        <property type="nucleotide sequence ID" value="XM_007697198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZZ3"/>
    <dbReference type="GeneID" id="19136933"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32865"/>
    <dbReference type="HOGENOM" id="CLU_187295_0_0_1"/>
    <dbReference type="OrthoDB" id="3689183at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="92" mass="10531" checksum="9AE295847086293D" modified="2013-05-01" version="1" fragment="single">VELLLTAQLAYNSTKSAITKHSPHYANYRYKPTAHRDPKDIESIAVEADDKAKLMRELHEELSKNIAQRNLTTSKAANKLRIERPIFKKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0B0</accession>
    <name>M2T0B0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 33 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_342943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701945.1">
        <property type="nucleotide sequence ID" value="XM_007703755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0B0"/>
    <dbReference type="GeneID" id="19137573"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_342943"/>
    <dbReference type="eggNOG" id="ENOG502QTE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007128_0_0_1"/>
    <dbReference type="OMA" id="NPNAGIC"/>
    <dbReference type="OrthoDB" id="504663at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43752">
        <property type="entry name" value="BNR/ASP-BOX REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43752:SF2">
        <property type="entry name" value="BNR_ASP-BOX REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="369" mass="41812" checksum="F1FBCBA0DB099413" modified="2013-05-01" version="1">MLDFNAELNVQSNKPLFASNYIPASTVQVHASNLLQLPNGDLLCAWFGGSQEGLSDICIHLSRLKKGSRVWSTPQKISDDSERSEQNPVLFLVPGTTTLWVMYTAQPAVNQDKAIVRYRVSSDGGQTWSLAQNLFDDEGLFIRQPVTFLEDGTWVLPAWYCRNPPGFCWVGSDDISVVKYTRDGGKTWQEKEVPNSIGAVHMNIKALLDGSYIAFYRSRWADNIYMSTSTNCIDWTEPKPTPLPNPNSGICFEFEEGQAKREGLYDDITPEDDKRINQRGSTRDAVWGVPRKMMTVGVSSDGGRTWKSKTLQVGDGFCMTNNSRTKENRELSYPSIWVERNANDVVNVAFTFWRQRIKFIRFDVDWVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0S3</accession>
    <name>M2T0S3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_269327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695823.1">
        <property type="nucleotide sequence ID" value="XM_007697633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0S3"/>
    <dbReference type="GeneID" id="19135579"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_269327"/>
    <dbReference type="HOGENOM" id="CLU_2263524_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="103" mass="11558" checksum="675D216FEAF24E52" modified="2013-05-01" version="1">MSLSDATADTDPSSLACAVTVDRNQSRLPEKTSRTDRINLILQSLSPSIISFHSRTYRFAISESIARQVDNSTSELAIEQVAPSLFQLVLLSFYLYYYVHPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1J9</accession>
    <name>M2T1J9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_37947</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701035.1">
        <property type="nucleotide sequence ID" value="XM_007702845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1J9"/>
    <dbReference type="STRING" id="665912.M2T1J9"/>
    <dbReference type="GeneID" id="19139129"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37947"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_1_2_1"/>
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    <dbReference type="OrthoDB" id="372395at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:aspartate-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AspRS_cyto_N"/>
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        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
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        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Aa-tRNA-synt_II"/>
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        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
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        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
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        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="377"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD63071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1043" mass="117039" checksum="BA624417297740F1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1R7</accession>
    <name>M2T1R7_COCSN</name>
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        <recommendedName>
            <fullName evidence="12">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_335927</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701252.1">
        <property type="nucleotide sequence ID" value="XM_007703062.1"/>
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    <dbReference type="STRING" id="665912.M2T1R7"/>
    <dbReference type="GeneID" id="19137227"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_335927"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_10_2_1"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000024">
        <property type="entry name" value="Mitochondrial protein import protein MAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD62967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46781" checksum="ADBCAAFE439112E5" modified="2013-05-01" version="1">MVKDTKLYDTLGVSPDCSEAQLKSAYKKGALKWHPDKNAHNPEAADKFKDLSHAYEVLSDPQKRQIYDQYGEEGLEQGGMGGGGGMAAEDLFAQFFGGGGGPFGGMFGGGMGGGREQGPKKARTISHVHKVSLEDVYRGKVSKLALQKSVICPKCNGAGGKEGAVKKCAGCDGRGMKHMMRQMGPMIQRFQTVCPDCQGEGEIIRDKDRCKQCNGKKTIIERKVLHVHVDRGVKSGHKIEFRGEGDQLPGVEPGDVVFEIEQKPHPRFQRKDDDLFYHAEIDLLTALAGGQIHIEHLDERWLTVDIIPGECISPGEVKVIRGQGMPSYRHHDFGNLYIQFDVKFPERLSNEEGGPMNPEQIRALESVLPPRKVPDVMPPPDAMTEDFTLEDVEQGGEGARARGMGGMEDDEDEMHPGAERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T311</accession>
    <name>M2T311_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_200131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700658.1">
        <property type="nucleotide sequence ID" value="XM_007702468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T311"/>
    <dbReference type="STRING" id="665912.M2T311"/>
    <dbReference type="GeneID" id="19134130"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_200131"/>
    <dbReference type="eggNOG" id="KOG2416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016396_0_0_1"/>
    <dbReference type="OMA" id="SKCFVAY"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="662" mass="72625" checksum="180046BE1587545E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2T364</accession>
    <name>M2T364_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_37257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700377.1">
        <property type="nucleotide sequence ID" value="XM_007702187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T364"/>
    <dbReference type="STRING" id="665912.M2T364"/>
    <dbReference type="GeneID" id="19138937"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37257"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="OMA" id="GVFMAFH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD63482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="154" mass="17638" checksum="27CF1E023270A686" modified="2013-05-01" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDGDGKIERLRRECPQPECGAGVFMAAMHNRQYCGKCHLTYVFDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3P7</accession>
    <name>M2T3P7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_31828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694121.1">
        <property type="nucleotide sequence ID" value="XM_007695931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3P7"/>
    <dbReference type="STRING" id="665912.M2T3P7"/>
    <dbReference type="GeneID" id="19136540"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31828"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_0_1_1"/>
    <dbReference type="OMA" id="NIMTFRL"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="124"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="488" mass="54509" checksum="0B4D12B54D0F8493" modified="2013-05-01" version="1">MPAGFDSSSLTAEQLPELLKDDLSVKVAGIDVDGILRGKLMAKKKFLSIANEGFGFCSVIFGWDMHDQTYFKELAISNKENGYRDLIAIPDLTSFRRIPWENNVPFFLISFYDPDTKDTLSACPRSLLKRTVDKLRGKGYGAMAGAEYEFYQFRAPQSHDGSEKNTSSTASFLRNNPVDALPSLTEGMFGYSITRPVHNQDYYYSIFNTCAEFGCGIEGWHTESGPGVFEAALEFGSIESMADKASLFKLVVKSLGSKYGITPCFMAKPREGLPGNSGHMHVSIVDADGKNLFYREEEDKNAPYSDIRYLSDLGRHFLAGLIDGLPDIMPILAPNVNSYKRLVENFWAPVTVSWGLEHRAASIRLISPPTSSPKATRFEVRVPGADTNPHFVLAAILALGWRGIEKKMEISIPPLGKGEDVGSESDKGERLAKSLKEATERFMRKESVAREVFGDQFVEHFGGTRQHEIRLWDEAVTDWEVRRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T444</accession>
    <name>M2T444_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_207272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694590.1">
        <property type="nucleotide sequence ID" value="XM_007696400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T444"/>
    <dbReference type="GeneID" id="19134345"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_207272"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053582_0_0_1"/>
    <dbReference type="OMA" id="MSGLYYQ"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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        </location>
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        </location>
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        <location>
            <begin position="14"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD69190.1"/>
        </source>
    </evidence>
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        <source>
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    <sequence length="376" mass="41497" checksum="D451AB19A29A4FFD" modified="2013-05-01" version="1">MAMHLASMVHGSVRDREAFQHPQHPAYYQQPQPRGYAMSGVAASSYPVQPPAHTQQVEQQYRQQVQHQQQQQQQQQPQKQQRPQSPPSPPAEEKKPSLPSISSLLEFAGNEKTASSDSASQSPKSQQRKSASPQLRQEQQPQPQYTPISAPNNSRMTLPPTPPMHPDVAHDGNQSPSVASNHSATSTPYFVGGALNNMEPHQQRQNFSTVPPMKRDSLQSHSMSPYSASMYGQSPYQSSPGAASSASFYSPEQHSYNSTPLYSQRPLPSNFQPHAMPLPVPVPSPAANGSNPWQHHHYISTSSQSQFPQPQDRYICSTCNKAFSRPSSLRIHSHSHTGEKPYKCPQPGCGKAFSVRSNMKRHERGCHAASSTTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="362"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD64352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="408" mass="45700" checksum="7CB2E8DA512635D1" modified="2013-05-01" version="1">MAPSKPSKPSSSVTYNIRSITKNWKIHRVHECLPRALWPNKQFEATQWDIGILTLLSQISAIPNATIQDFRAKARRTIKARQERNGTAAGKVGWIKVTDLKAVLKEYEKEIAEADAAKTAQEEAELIGDVQTEVVELPKTPVAPVVDSEEEDEEQGSSEPLPGGKYQYLTHVRPLKVDLNPTASPPKKLVQAKATRGKKRQVEDEAMLDLSAIERPSVVQQDPDPRAPDDTGFLSDLEPEKTEQKERKKKRLSRLEQYPVRVPHWQRDLDDVAADPLLLSNGTGAASGAVPEGTLGNGKDNDEDLEMNLDNLPSIPVNATVKERKEMEELRLRMEQRIWKIKVLRIKEREGRSNEIVGQGEIVDDDVSQGEEGDAEDENDDLDERDEIEHDENGAIGEGRVLRSRKAK</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="8">Histidine-specific methyltransferase SAM-dependent domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">COCSADRAFT_32544</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69895.1"/>
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        <property type="nucleotide sequence ID" value="XM_007696134.1"/>
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    <dbReference type="STRING" id="665912.M2T637"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_32544"/>
    <dbReference type="eggNOG" id="ENOG502QS9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="659at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
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    </dbReference>
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        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
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    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="19"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="541"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="739"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="602"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699217.1">
        <property type="nucleotide sequence ID" value="XM_007701027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6M1"/>
    <dbReference type="STRING" id="665912.M2T6M1"/>
    <dbReference type="GeneID" id="19138386"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355670"/>
    <dbReference type="eggNOG" id="ENOG502S31Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_1_2_1"/>
    <dbReference type="OMA" id="WHRYFTK"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026279" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="69"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD64592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="267" mass="30111" checksum="F12963E28A9FE7F2" modified="2013-05-01" version="1">MLFNSIVLFAAASLTHAVVLPAPQVSDRSKCIDSPQRIEWRKLEPAKQKSHIDAVLCLKTKPSRISLKSLFDDFPHVHFQVASSIHNQATFLPWHRYFTKCYFDALGECGYSGPGTQTLDHDSLIVSPFMSSTTGFDGNGDPNRSEYYAPNGQILSCVDSRPFKDLRPEYLPNSPTEITEGGHCFFRKLAEVNKLEAWNTMKDTLTPEYVANQQKLEVFAKFAPALEANPHGTIHASLGGEMNPTTSPNESLFFLHHPQIDRLWWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7U4</accession>
    <name>M2T7U4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_198285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698496.1">
        <property type="nucleotide sequence ID" value="XM_007700306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7U4"/>
    <dbReference type="STRING" id="665912.M2T7U4"/>
    <dbReference type="GeneID" id="19134059"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_198285"/>
    <dbReference type="eggNOG" id="KOG1009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010127_3_1_1"/>
    <dbReference type="OMA" id="CIVSNLH"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="309"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="571"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="675"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="575"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="754"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD65306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="771" mass="82192" checksum="39F4119F1174479E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8X6</accession>
    <name>M2T8X6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_198625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698774.1">
        <property type="nucleotide sequence ID" value="XM_007700584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8X6"/>
    <dbReference type="STRING" id="665912.M2T8X6"/>
    <dbReference type="GeneID" id="19134065"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_198625"/>
    <dbReference type="eggNOG" id="KOG0812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044998_0_1_1"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD65701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="344" mass="38424" checksum="B9EE7FA82DCB2BEA" modified="2013-05-01" version="1">MAVSIQDRTEEFRSILAQAQRRQAQSKTGAQRQSLLTAQEKAQANASPRRQRSEFARNAAEVARGVASTMQKLERLSQLAKRKTLFDDRPVEFDELTFVIKQDMSALSGQVQALQQMNAKLHPKAKPGLDQEGEHNSNVVMLLKDKLQNVGTNFKDVLEVRTKNMQASRSRTEQFLSSAAQQSHSSLEPGRTDSPLYQTPQRGRSPGGFGRNTNAVQQDLLSLEPSGSSALTRGGAQSDAQLLLMEEAQPQNMYIQERGRAIESIESTIQELGGIFSQLAQMVSEQGEQIQRIDANTEDVVDNVEGAQRELMKYWSRVQGNRWLVAKMFGVLMIFFLLWVLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9M7</accession>
    <name>M2T9M7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_159527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698960.1">
        <property type="nucleotide sequence ID" value="XM_007700770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9M7"/>
    <dbReference type="STRING" id="665912.M2T9M7"/>
    <dbReference type="GeneID" id="19131968"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159527"/>
    <dbReference type="eggNOG" id="KOG0067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OMA" id="TGTQFET"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="148"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41937" checksum="B7E3084507F1D47D" modified="2013-05-01" version="1">MDSQSPINLAVLDDYHGIASKHFDHINPSKVEITVFNDTLPSYLHPRTSDEDRKALVNRLKPFAVLSTLRERTAFPGELLRQLPNLKLIFATGGKFESWDLNTMKELGISVYVAPGKGRTDGKGSVQSPRSLPTKQGGGHPTTQHVWALILGLARNIAADDAVVKGKGGPAGWQTELAVGLQGKTLGLVGLGRIGAHVARVGVLAFGMRIICWSANLTQDKADALAQEYGLPIRGAGMLAEDEKTFQVVSKEELFQTADVVSLHYVLSDRSRGIVAARELASMKPSAFLVNTSRAPLIDEAALLDTLQDGRIRGAALDVFDIEPLPADSPWRNVDWDRKGNSRVLLTPHMGYVEEGTLTVWYEETVENLERLIEGRELLHRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCT3</accession>
    <name>M2TCT3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate-binding module family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_196954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696825.1">
        <property type="nucleotide sequence ID" value="XM_007698635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCT3"/>
    <dbReference type="GeneID" id="19133997"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_196954"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011025_0_0_1"/>
    <dbReference type="OMA" id="IGYLQCA"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026325" evidence="4">
        <location>
            <begin position="24"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="821"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="783"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="789"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD67076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="859" mass="90525" checksum="310D74C32795796C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDG0</accession>
    <name>M2TDG0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_136082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696973.1">
        <property type="nucleotide sequence ID" value="XM_007698783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDG0"/>
    <dbReference type="GeneID" id="19130998"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_136082"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_1_1_1"/>
    <dbReference type="OMA" id="DMCIFIQ"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="310"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD67276.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="371" mass="41291" checksum="8CDE3D5C70FAD600" modified="2013-05-01" version="1">MFPPTQGLRLDIDAISQIFGSISIACWIVVFSPQIIENWKRSSAEGLSVVFIVIWLLGDFFNIIGAVLQGVLPTMIILAVYYTLADIVLLLQCFWYKGFTLRDDFKKPTSDSDEDSITSEQSPLLGERRPHSNGSPYNNQHGNGIEVQRPRISDYERRGSGNSQSSFRERYLSIDGTHLSPVTPLLDDPTSGRSNSAIATSPPPQQSNLQMIIFNAGTVILVCAAGVFGWYLSARNSTVPRDSDPPADSTLHFNLWGQISGYVCAALYLGSRVPQLLLNYRRKSTEGISMLFFLFACLGNLTYVLSILVYKPKCGGNMCHDGEGRAEYVKYIAVNMSWLLGSFGTLLLDAGVFVQYFMYRVDDEESSDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_188069"/>
    <dbReference type="eggNOG" id="ENOG502QUR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="AMMPNED"/>
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    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF02449"/>
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        <source>
            <dbReference type="Pfam" id="PF18120"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDN9</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="665912.M2TDN9"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_84296"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="64" mass="6985" checksum="AE66758F4BA51EA4" modified="2013-05-01" version="1">MKGVLDEDIVTVFGADIHAAITICSIRAEELREGVGRNNCVSITFLERRATIDLILSVLEGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2TE19</accession>
    <name>M2TE19_COCSN</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696765.1">
        <property type="nucleotide sequence ID" value="XM_007698575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TE19"/>
    <dbReference type="GeneID" id="19135853"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_283805"/>
    <dbReference type="HOGENOM" id="CLU_2183480_0_0_1"/>
    <dbReference type="OMA" id="MLHHAPR"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="110" mass="12280" checksum="FC445AB21C980907" modified="2013-05-01" version="1">MLHHAPHTMHATLLSSLRPSPPSSSPFLPRAQRIHSLRARTTSPRTHLPLSFPSSAPLHSTIPKLLLLHPTLTIPLAPSTNPLWPRLPLRTPFPFPNPLSNVRTMHRITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEL6</accession>
    <name>M2TEL6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">COCSADRAFT_168415</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696910.1">
        <property type="nucleotide sequence ID" value="XM_007698720.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2TEL6"/>
    <dbReference type="GeneID" id="19132575"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_168415"/>
    <dbReference type="eggNOG" id="KOG1907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_0_1_1"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="393"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="548"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="814"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="1042"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="1237"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <source>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJF3</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Otillar R."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
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                <person name="Glaser F."/>
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                <person name="Lindquist E.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694909.1">
        <property type="nucleotide sequence ID" value="XM_007696719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKF0"/>
    <dbReference type="GeneID" id="19134419"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_212259"/>
    <dbReference type="eggNOG" id="ENOG502RZ90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912422_0_0_1"/>
    <dbReference type="OMA" id="VAFWLNH"/>
    <dbReference type="OrthoDB" id="2150942at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34822" checksum="06ED2431115E24AE" modified="2013-05-01" version="1">MASETGETSKIDSGKFYNEYKGHSISDLTKFRAITLTERPDKPIIYLAGDSSLDNKFWIKEPISNADPSQIPAIYHKTLADPITLIPDVAYWLNHLLSARATCINTAVEESLLRERDTDLPHDAFIRSNIRSNDILVVSVGSNDIALNPTVETSAHMFQLAWLTPRKSIEDGSAWGLPYFRHLFGSKIQDYISRLTAVTKPRAVVVCMIYFPLESGKGQSGWADGKLRVLGYERNPGQLQAAIRELYKSATEEISVEGVEVLPCKLFEVLDGKEARDYVERVEPSGEGGRKMAEEFVRVLEGVLGGKGVGSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2TL83</accession>
    <name>M2TL83_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">COCSADRAFT_32554</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694326.1">
        <property type="nucleotide sequence ID" value="XM_007696136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TL83"/>
    <dbReference type="STRING" id="665912.M2TL83"/>
    <dbReference type="GeneID" id="19136823"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32554"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="66"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="277"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="72"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="452"/>
            <end position="455"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="470"/>
            <end position="472"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="487"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="615"/>
            <end position="616"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="621"/>
            <end position="625"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMD69906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="696" mass="77352" checksum="67ABF8717BCD76B6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2TN45</accession>
    <name>M2TN45_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_132641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695236.1">
        <property type="nucleotide sequence ID" value="XM_007697046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TN45"/>
    <dbReference type="STRING" id="665912.M2TN45"/>
    <dbReference type="GeneID" id="19130859"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_132641"/>
    <dbReference type="eggNOG" id="KOG0364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000023">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD70102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="548" mass="59784" checksum="87A1C884EA7B06F9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2QS90</accession>
    <name>M2QS90_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_104849</name>
        <name evidence="4" type="ORF">COCSADRAFT_350662</name>
        <name evidence="3" type="ORF">COCSADRAFT_358781</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr</strain>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445762">
        <property type="protein sequence ID" value="EMD58069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EMD62797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696415.1">
        <property type="nucleotide sequence ID" value="XM_007698225.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701140.1">
        <property type="nucleotide sequence ID" value="XM_007702950.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706231.1">
        <property type="nucleotide sequence ID" value="XM_007708041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QS90"/>
    <dbReference type="GeneID" id="19129951"/>
    <dbReference type="GeneID" id="19138033"/>
    <dbReference type="GeneID" id="19138586"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104849"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_350662"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_358781"/>
    <dbReference type="HOGENOM" id="CLU_200106_0_0_1"/>
    <dbReference type="OrthoDB" id="10379771at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="86" mass="9364" checksum="AA3D106DB35FFCDD" modified="2013-05-01" version="1">MLHGVRVYTSLSWSALRQVSITLVFLDHNECNNEIQPILISVAFGPAIPYFPAIPGMVVMLGMAAIPRRPAIPRMVALGGMAHHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSK3</accession>
    <name>M2QSK3_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_42087</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445680">
        <property type="protein sequence ID" value="EMD58164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007707944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSK3"/>
    <dbReference type="GeneID" id="19140160"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_42087"/>
    <dbReference type="HOGENOM" id="CLU_204100_0_0_1"/>
    <dbReference type="OMA" id="TRHPAKT"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="69" mass="7386" checksum="DB781BC506B8392B" modified="2013-05-01" version="1">MAEGLWTSTSEGNDHRGAGGHVMCHPAKTRHPAKHGMAMGLGMACHHRHPAKEQENGMDGMAGLEAMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSV5</accession>
    <name>M2QSV5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_204499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD58259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706024.1">
        <property type="nucleotide sequence ID" value="XM_007707834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSV5"/>
    <dbReference type="GeneID" id="19134297"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_204499"/>
    <dbReference type="eggNOG" id="ENOG502S098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006016_0_1_1"/>
    <dbReference type="OMA" id="WERCTES"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07491">
        <property type="entry name" value="Peptidases_S8_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="716"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="722"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="759"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD58259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115019" checksum="5FE41071D70C5B78" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2QVR6</accession>
    <name>M2QVR6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_175741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704965.1">
        <property type="nucleotide sequence ID" value="XM_007706775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QVR6"/>
    <dbReference type="GeneID" id="19132987"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175741"/>
    <dbReference type="eggNOG" id="ENOG502T5NP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153331_0_0_1"/>
    <dbReference type="OMA" id="TFQRHNL"/>
    <dbReference type="OrthoDB" id="3882258at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="139" mass="15335" checksum="3D95E76BC372E085" modified="2013-05-01" version="1">MSGAAGAPPPPPPPPGPSTHGNPFDDLPAELLLIIYEYVGNSNLVNLALAIYPTFQRHNLSPELTSTTLAHMLSLSSRPPMYPGIVYMPAELWLCVARYLEPADILSMMFTFGAVFGQPLTQSTRDRLRVWSRRLRENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZ13</accession>
    <name>M2QZ13_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_40686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704152.1">
        <property type="nucleotide sequence ID" value="XM_007705962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZ13"/>
    <dbReference type="STRING" id="665912.M2QZ13"/>
    <dbReference type="GeneID" id="19139807"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40686"/>
    <dbReference type="HOGENOM" id="CLU_3050189_0_0_1"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="5657" checksum="2A00033E33B6A6EF" modified="2013-05-01" version="1">MHLQSAIGNGDGSYSVLPAGTVGQRQAIAVLSRLYFTKTAEKPLAGVRVGIKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3X0</accession>
    <name>M2R3X0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_173298</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702275.1">
        <property type="nucleotide sequence ID" value="XM_007704085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3X0"/>
    <dbReference type="STRING" id="665912.M2R3X0"/>
    <dbReference type="GeneID" id="19132842"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_173298"/>
    <dbReference type="eggNOG" id="KOG1783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_7_4_1"/>
    <dbReference type="OMA" id="EQTVEYV"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
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    </dbReference>
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        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sm-like ribonucleoproteins"/>
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    </dbReference>
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        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0507">mRNA processing</keyword>
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    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD61904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="89" mass="9467" checksum="4C0665D699151073" modified="2013-05-01" version="1">MSTNGESPAPEAAPDSRDPSGFLSEIIGAPVTVKLNSGIIYKGDLQSVDGYMNIALERCKEVSDGKVTRNWGDAFVRGNNVTYICADNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2R4H4</accession>
    <name>M2R4H4_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_173468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R4H4"/>
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    <dbReference type="GeneID" id="19132857"/>
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    <dbReference type="eggNOG" id="ENOG502RQ94">
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    </dbReference>
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    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="NAA25_NatB_aux_su"/>
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    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="944" mass="107566" checksum="ACF032536452D512" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2R766</accession>
    <name>M2R766_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylosuccinate lyase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700972.1">
        <property type="nucleotide sequence ID" value="XM_007702782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R766"/>
    <dbReference type="STRING" id="665912.M2R766"/>
    <dbReference type="GeneID" id="19139066"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37729"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_3_1_1"/>
    <dbReference type="OMA" id="KFVHWGA"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01597">
        <property type="entry name" value="pCLME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF2">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="2">
        <location>
            <begin position="392"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="475" mass="52186" checksum="E3C66F3A0EE95720" modified="2013-05-01" version="1">MFLLRRAPLRAVPRLSTIRPQRRLLGSVSAIDSVIFRTLFGTDEIRKVFDDKAYIDRCVDAETALARAQSKCNVIPSHIGEVVTSKAREAQLDYDKLRRETEIVGYPIFPLVRQLSASCGDEAGRYVHWGATTQDIMDLASILQMKEGLQIVERTLRSVIKNLEHLSRKHRDTPMAGRTHLQHALPITFGHKCAIWLSGFQRHLERLEQLRDRALMVQFGGAAGSLASLGSGDDGIRVRKEMAKDLGLTDPPITWHVARDGVAEITNYLALVGGSLGKLALDIIIMSSNELSEVSEPFVPHRGASSTMPQKRNPISSEVILAASKILRSNAGLVLDGMVSDFERASGPWHLEWVAVPESFVIAVGALNQADFALSGLVVNPKQMLTNLYSTRGLIVAEAVMMGLAPHVGRSKAHDIVYEACKESIERDTSLLEALQTRSEITDKISNEELSSLCDAKNYLGSCGLMVDEVLAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8D5</accession>
    <name>M2R8D5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_172590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701418.1">
        <property type="nucleotide sequence ID" value="XM_007703228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R8D5"/>
    <dbReference type="STRING" id="665912.M2R8D5"/>
    <dbReference type="GeneID" id="19132799"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_172590"/>
    <dbReference type="eggNOG" id="KOG0729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_6_2_1"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD63199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="439" mass="49178" checksum="D3A1FD0FC7ECE131" modified="2013-05-01" version="1">MPSATGQSWEKYQKNFADDEVEEKKITPLTDEDIQVLKTYGAAPYSAELKKLEKEIKDKQQTINEKIGVKESDTGLAPPHLWDIAADRQRMQEEQPLQVARCTKIIQDEKDSEKSKYVINVKQIAKFVVNLGERVSPTDIEEGMRVGVDRNKYQILLPLPPKIDPSVTMMTVEDKPDVTYGDVGGCKEQIEKLREVVEMPLLSPERFVNLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLDGFDARGNIKVMFATNRPSTLDPALMRPGRIDRKIEFSLPDMEGRANILRIHAKSMSVERDIRWELISRLCPNSTGAELRSVATEAGMFAIRARRKVATEKDFLAAVDKVIKGNLKFNSTATYMQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2R9U9</accession>
    <name>M2R9U9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_48715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700497.1">
        <property type="nucleotide sequence ID" value="XM_007702307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R9U9"/>
    <dbReference type="GeneID" id="19140248"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_48715"/>
    <dbReference type="eggNOG" id="ENOG502SNI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_1_1"/>
    <dbReference type="OMA" id="HAEDGIM"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="8"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="252" mass="28014" checksum="C3860B85E0118709" modified="2013-05-01" version="1" fragment="single">FALLVALLRCWVRLKIVKSFGRDDWVMISALVPATACFLSYMTEISLGLGSQVDLLEANMSNYHKLLLARLLHQVFVVMALGLVKVSICLFLLRLVMKKLYIRALWGIIIFMVVFTIGSVLSIILQCIPISAGWNHSLRPPPLGVGSAKCYSLGTFRKIGLFNGVIHILSDILLALLPTPLIWRLQMVRRARFTLIVVLSVGILAAIAGIIRQVSVGPLDEYDAYSIWNFTELHLGIIAASLPALKPIFKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RE64</accession>
    <name>M2RE64_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_317487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699562.1">
        <property type="nucleotide sequence ID" value="XM_007701372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RE64"/>
    <dbReference type="STRING" id="665912.M2RE64"/>
    <dbReference type="GeneID" id="19136509"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_317487"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="OMA" id="VSETHAW"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="325" mass="35488" checksum="D41DF97A9E906C00" modified="2013-05-01" version="1">MASFPTFLKSQLFYKPRLPQPETFAGKTVIVTGANTGLGLEATRHFVRCGAATVIIACRTLSKGEAAKRDIEESEKRTGVLQVWELDLSSYASVKAFTKRCETLPRLDVCVENAGIATGKFSRAEGHEAHITVNVISTFLLALLLLPIMRRSAFSTGTTPYLTIVTSEVHHWTQLPQKKEPSIFAALDDESKADMADRYNVSKLLEILALRYMTRVLIKDRAKYPVVINCVTPGLCKSDLVKDMGMAPVVFKTLLGRTVEVGSRTLVNAAALPDSAGEYIIDDHVSEPSTLAVSEEGAALSKRVWFELADILEKACPGVTQNIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2REU9</accession>
    <name>M2REU9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">37S ribosomal protein Rsm22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_304121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698499.1">
        <property type="nucleotide sequence ID" value="XM_007700309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2REU9"/>
    <dbReference type="STRING" id="665912.M2REU9"/>
    <dbReference type="GeneID" id="19136240"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_304121"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007075_0_0_1"/>
    <dbReference type="OMA" id="CTNHSTC"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD65309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="91639" checksum="256DC24612E50941" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RKU0</accession>
    <name>M2RKU0_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_34127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696546.1">
        <property type="nucleotide sequence ID" value="XM_007698356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RKU0"/>
    <dbReference type="GeneID" id="19137464"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34127"/>
    <dbReference type="eggNOG" id="ENOG502RZZ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2170855_0_0_1"/>
    <dbReference type="OMA" id="CAAKQIY"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="110" mass="11618" checksum="11988B55086A664B" modified="2013-05-01" version="1">MSVGSVVKQNIWVTTLSRDPMTVGAAVAIAMINAVSNSLSTYSSVTSISSASTEAGFPQPALLIGSTIYVVGILTELVAGIQREQFKADPNNKGKMCTGSLWSLARYINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2RN17</accession>
    <name>M2RN17_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_267866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695743.1">
        <property type="nucleotide sequence ID" value="XM_007697553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RN17"/>
    <dbReference type="STRING" id="665912.M2RN17"/>
    <dbReference type="GeneID" id="19135559"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_267866"/>
    <dbReference type="eggNOG" id="ENOG502SC5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1390108_0_0_1"/>
    <dbReference type="OMA" id="SIGYMEY"/>
    <dbReference type="OrthoDB" id="3690055at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD68024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="196" mass="22326" checksum="728AB11CCE73C331" modified="2013-05-01" version="1">MLLHSSRTAFLKKDTEPCTTTSTTPCPICHETITCTTSTRSLRICIRNTKTAARMLILTCRRTYYTSRNTGSSSSNILLRPRTKSSRSNSMMRIKRCGHTFCYDCLETWVQKQNTCPMCRDRLFSGSRREKYRSESDQGDRVLLLALRGYLDMREAREVSDPAVRSAMGDGHDYGGDEWADVDVYGDMMVRGGEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2RNE2</accession>
    <name>M2RNE2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_79852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695830.1">
        <property type="nucleotide sequence ID" value="XM_007697640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RNE2"/>
    <dbReference type="GeneID" id="19140752"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_79852"/>
    <dbReference type="eggNOG" id="ENOG502THID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087336_0_0_1"/>
    <dbReference type="OMA" id="WGEGHNL"/>
    <dbReference type="OrthoDB" id="3733501at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32387" checksum="7B7CDA92FD7BE73E" modified="2013-05-01" version="1">MPGFLDLPLELRNHVYEMLLGEELEPCFRGVMVVSEHYVRNDLPLRCYRGLLRVCRQTYREFKQAIQHQVASKRLRYELDITFSHGRPYFSLTWIHFAALSPTINQLCINVDLRTREPLRDGPRESFVPHEHELAHLLEHSPTCFAKQLFDYIAIFLKTLANLLFQGDPHFSVLYTESMTLNLRTPTKVVALGGSGHNPIALSRRLRVDQTEARKLHDTMRDTLRATSKHFQAFNANECDRLFPLIQIGCLRFATEGEVWGEGHNLVLAHDDFQWLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2RPY8</accession>
    <name>M2RPY8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_350318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696184.1">
        <property type="nucleotide sequence ID" value="XM_007697994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RPY8"/>
    <dbReference type="STRING" id="665912.M2RPY8"/>
    <dbReference type="GeneID" id="19138018"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_350318"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_4_0_1"/>
    <dbReference type="OMA" id="MQVVPYS"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="127"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="210"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="412"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD68634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="488" mass="51302" checksum="B690B0966B84CCFA" modified="2013-05-01" version="1">MSASPTIAASSTKRPLEEPSSPAGLNDQPDAKRPALDKMVKDEAPSADAIDIAQPVKAESVDVEGISEEQAKVVPVATPAVENGTEPIQTDTIVPDAPSILETQPIQSTSGANGRPVNSNQQVDETNWLHVRACIGTSEAATIIGKGGENVTQIRRLSGAKCTVSDYSRGAVERILTVSGQVDAVSKAFGLIVRTLNQEDLETPSTSTSKAYPMRLLIPHILIGSIIGKAGVRIREIQEASNAKLNASDTLLPNSGERSLIVLGVADAVHIAVYYVAQTLVEQLTERFGGPAASQYATRSGMAANVVPGGMSVQPYVPQPAGGQYSHPQNFRRQEPAQRTPAHGGYGAPHMHGQPPQQSPYGHPNMPYGAASPSRGPYGGPAAPTPYGAHPAAAPVAHGAAPHAPVGAIPGQPLTQQIFIPNDMVGAIIGKGGAKINEIRQLSGSVIKINEPTDNSNERLVTITGTQECNQMALYMLYSRLESEKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQB4</accession>
    <name>M2RQB4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_80971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696289.1">
        <property type="nucleotide sequence ID" value="XM_007698099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQB4"/>
    <dbReference type="GeneID" id="19140812"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80971"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OMA" id="RKWPLTI"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF138">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="57"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="503" mass="54778" checksum="30F69294F03925D8" modified="2013-05-01" version="1">MTPCDPNEIYHARNEEKPQAEQEISGGAQIPNHAVTFDSPHDDQNPQDWASWKKLVISTTACTGTLIASFNSAIYNAAAASSSTEFNVGNRVTALGTSLFVLGFASGPVIWAPGSEMLGRRWPLVLGVFGSCVFTFGSGMAENVQTLIVCRFFAGLFGASPLCVVPAVLADLYNNTYRGVAISMYALTVFGGPFLAPIVGDFIVASHLGWRWTLYLPAILGLANSLFLLLLFRETFAPLVLVQKAQLLRWQTGDWKIYAEQERLKLDVHAVVKKYLTRPLCMLATEPIILLVSTYMSFIYGLVYALLGAYPYVFQHVHGMQTGVRTLPFLGLLMGVVLALIFILGQHRSYCRKLEANNGKTIPEWRLGPAILGAVVFTVGLFSFAWTGFTNAVHWMAPTAAGVFIGFGVLCIFLPCFNYLVDAFLPLAASAVAANIMLRSAVAAGFPLFSTQMFENLGIQWAGMLLACLATIMIPIPIVFRAYGPTLRAKSKILVEAASEVMV</sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_105351</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RRG5"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_105351"/>
    <dbReference type="eggNOG" id="ENOG502SNDG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332033_0_0_1"/>
    <dbReference type="OMA" id="HEEWHAP"/>
    <dbReference type="OrthoDB" id="3944128at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="873" mass="89999" checksum="426A85CA50BDEEBB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRK3</accession>
    <name>M2RRK3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcipressin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_31952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694162.1">
        <property type="nucleotide sequence ID" value="XM_007695972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RRK3"/>
    <dbReference type="STRING" id="665912.M2RRK3"/>
    <dbReference type="GeneID" id="19136593"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31952"/>
    <dbReference type="eggNOG" id="KOG4019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050705_0_0_1"/>
    <dbReference type="OMA" id="RIVCSFH"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12434">
        <property type="entry name" value="RRM_RCAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28400" checksum="70596D8F2FADE251" modified="2013-05-01" version="1">MQATIPSPQRSRASSRSKSPLSIDLSDLPPLVEPSPPSNTLIITNLLAPEIFQLSTLTEIRETINQHAKVHTWAPLKSFRRIVVSFFDTDSAIQVRQALDGEQLMGFRIRVYFGVNTPMNPSDQHLALPKSDRLFFISPPPSPPMGWEIKEEDAPNTIVHPEDLAAALAKLHANPEASSPTDHGSNTITRRRTGSTTVVYHPEDHGDSPNLPAISVEDTTETPEALTPLDAMEGVEGPIASQKAQGMTTSTARPPVELMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXH8</accession>
    <name>M2RXH8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_253724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704746.1">
        <property type="nucleotide sequence ID" value="XM_007706556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXH8"/>
    <dbReference type="GeneID" id="19135275"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_253724"/>
    <dbReference type="HOGENOM" id="CLU_1299600_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="212" mass="23921" checksum="A71F34AEF7547620" modified="2013-05-01" version="1">MSVLTPLFDAYSASFARARFFLISAVLLLSTQTRMHASTLPVGIVAPSLRIDRFQQLMLACCNSKDNPADTLSRHLRRYEPETIVVFIVLVFNTHRSLFEKVLRGFLVALGFLARGVICCQMSIIVDYRQEDLMRVANLSAIQAKLEEQIGVIVGSFQCLKRPVYEWLKRHGLLGDEQNMARGFVGDSSFQVDEDDVGDTSKLRAQKVKGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2RY67</accession>
    <name>M2RY67_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_346456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704262.1">
        <property type="nucleotide sequence ID" value="XM_007706072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RY67"/>
    <dbReference type="GeneID" id="19137776"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_346456"/>
    <dbReference type="HOGENOM" id="CLU_1120077_0_0_1"/>
    <dbReference type="OMA" id="AFKKRCY"/>
    <dbReference type="OrthoDB" id="3775889at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="254" mass="27832" checksum="86F50238B4E5BB40" modified="2013-05-01" version="1">MASSGNKRWGEAEPSANSWRSRPSSSSSSSSFSSSLPSFSPSPDSWRSRSSSSSSSSSSSSSSFSSSSLSPSPPPPKSQNSWATANNWRSGSPPKSLDKPATTPDFDKLTEGQVLYLGVPPPSSIFWQRQDASSPEGHPVVIVGKYRGKGGEECVKLRLVTSFGGQRLQDRKPFWQWKFFMLCENSQEQVQTEEVRLAKVASGCDAFKKRCYVNLSPNSLYHIEYRHLGVFAIQPNIRFDSLSTSEIKNAPANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZE3</accession>
    <name>M2RZE3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_174708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703779.1">
        <property type="nucleotide sequence ID" value="XM_007705589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZE3"/>
    <dbReference type="STRING" id="665912.M2RZE3"/>
    <dbReference type="GeneID" id="19132925"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_174708"/>
    <dbReference type="eggNOG" id="KOG1251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_1"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="64"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="399" mass="42182" checksum="1343D6253242408B" modified="2013-05-01" version="1">MASTQIHPSLTRSNVEAAHALIKPHIHDTPVLTNTTLSNLASTPQAAEALEGTQWEGQEPVHPKINIFFKCENFQRIGAFKVRGAFHAVTRLIEKEGIDEVRKKGVVTHSSGNHAQALALAARTFSIPAHIVMPTISTPSKIAGTKAQNATVHFSGSTSTEREAVVATVINDTGATLIPPYDHPNIILGQGTLALELQEQATKLLAQSSSGNSKLDAVIAPCGGGGMLSGIAIALHGTGIRVFGAEPSFQGGDDARRGVAAGERVTSVKTLTIADGLRTPLGVHNWSVISKPEYVAGLFAVTEDQIKKAMRLVLERMKCFVEPSAVVGLAVVLFNEEFRGLVQREAGEEGWNVGVVFSGGNTTVEAIGKIFAEVPEAVKERQEGVLGMDGGREVENVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2S0H1</accession>
    <name>M2S0H1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_97082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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            <dbReference type="Pfam" id="PF12937"/>
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        <source>
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    </evidence>
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        <source>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2S4I3</accession>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152057_1_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="82"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9235" checksum="8BA06E6D50F9B6F7" modified="2013-05-01" version="1">MPSEVSDIKQFIEICRRKDAKSACIKKNKKVNNIKFKVRCSTNLYTLVLKDTDKAEKLKQSLPPGLTISDVGKKNPKGKRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2S650</accession>
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        <recommendedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_94329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502QT4U">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014765_0_0_1"/>
    <dbReference type="OMA" id="HVIDMVA"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:double-stranded DNA helicase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial translational elongation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="74"/>
            <end position="240"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD62588.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="75875" checksum="7C253C7BD17B4F30" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6B7</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD62678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19137581"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_343051"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="OMA" id="LFAFEHP"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
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    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31455" checksum="7AB4FE559946787B" modified="2013-05-01" version="1">MTDNGGTIDFKLYRYNPSMAAAVIFVILFILISGLHLYQMVRTRTWILIPFVIGGFFQFAGYIARAMSAAESPKWTVGAYSASTILLLVAPALYAASIYMMLGRIVLVTDGEHHSIIPKRWLTKIFVVGDVISFLMQGAGGGIMASGTISALHTGENIIIGGLVVQILFFGCFMVTSVLWHSRMVKNPTTRNLSGSIPWEMQLYSLYAASMLILVRSVFRLIEYAQGNDGYLISHEAFLYIFDSTLMWITMAILAWIHPSEITGLLKGEKGVAVRRGVEVYDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6M8</accession>
    <name>M2S6M8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_27296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700937.1">
        <property type="nucleotide sequence ID" value="XM_007702747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S6M8"/>
    <dbReference type="GeneID" id="19135657"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_27296"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818919_0_0_1"/>
    <dbReference type="OrthoDB" id="3727344at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37914" checksum="1D1BC7901F06EEF0" modified="2013-05-01" version="1">MGATLSSTNAIDTWSITVVFFGLFSLWHLGNIVYNLFFHPLKKIPGPFLARCSPWTVQEQAENLLLVGTNIITTHDKKLHRKLKRGIQPAFNSNSLKDQELLIQQQVRGMIGRVDEIIQKPGQVTNMGDVISESIWDLVSDLSFGDTLTGNGRIMFDYFINNANSVMAAYGLYDYLFPFGSWVLPSLIKSLGKLLKSFPYASTTTGHVVSASTLRNLAGYGTMAMTMTATFYQLLRNPEYMAVVQSELRNAFPSQESITADGLAKLHYLPSVIFETLRLMPPINTRFADRTCPGTKINGIYIPKGTVVSAKVFSMQRMPDYWAEMSFLQCLSRGSSVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2S783</accession>
    <name>M2S783_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_281353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445660">
        <property type="protein sequence ID" value="EMD58230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706080.1">
        <property type="nucleotide sequence ID" value="XM_007707890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S783"/>
    <dbReference type="GeneID" id="19135818"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_281353"/>
    <dbReference type="HOGENOM" id="CLU_1686419_0_0_1"/>
    <dbReference type="OMA" id="DAANGHM"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044653">
        <property type="entry name" value="AZF1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45988">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45988:SF18">
        <property type="entry name" value="C2H2-TYPE ZINC FINGER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD58230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="156" mass="16768" checksum="B1D6B167B086FF91" modified="2013-05-01" version="1">MEEVIREAVGSRQEKKKTLKEHANASPLGMRSNSLNQHNIKGPQLRCQTCTKKFLTQDAANGHMTSTGHGSPNIPCKTCAKKFFTQDAANGHMTSTGHGSPNIPCKTCAKKFFTQDAANGHMTSTGHGSPKIPCKTCAKKFFTQDAANGHMTAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2S9C5</accession>
    <name>M2S9C5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700486.1">
        <property type="nucleotide sequence ID" value="XM_007702296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S9C5"/>
    <dbReference type="STRING" id="665912.M2S9C5"/>
    <dbReference type="GeneID" id="19139046"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37666"/>
    <dbReference type="eggNOG" id="ENOG502RZMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043687_0_0_1"/>
    <dbReference type="OMA" id="ERNFAWM"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="388" mass="44491" checksum="5B9EA93E286E3E63" modified="2013-05-01" version="1">MAEKTPVQMNHQSYMLKPPFSPQPIPPNSNADADNTQSTVGITNQSGTISPSNTQPFLQSSTSQPLSALDSLPTITGKSDHIIRPEYEIPAFLAFDLDLARLNRIHGHLWMAGRPMRARPLHRYTMLGMQVIQTQQMDLHLLKFSSKLLIKPLPEWILCHKFWTDWICNYDDADGKREPGWLWKSAAGFLVSYVWLVTTPLDLKIAHENSLLPSFVTWHWWKAFVSDFISHVDIDTLHQVNKRYQFGDLRLGRINTTYRVRYAHTHFVRGYLWGYNRYVIFFQRKFSWVLIVFVFFSVVLSAMEVSFSLPSTSPISLENDQAFVQAAFAFVVFSMVSVLVILAFVVVIFVGTFVFNMVMAISHAGSEQRKRRELAVKRRQAVENGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2S9C6</accession>
    <name>M2S9C6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_41036</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704836.1">
        <property type="nucleotide sequence ID" value="XM_007706646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S9C6"/>
    <dbReference type="STRING" id="665912.M2S9C6"/>
    <dbReference type="GeneID" id="19139894"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41036"/>
    <dbReference type="eggNOG" id="KOG3146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074922_0_0_1"/>
    <dbReference type="OMA" id="VYATLIW"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD59155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="231" mass="26443" checksum="92A996A20C67BA85" modified="2013-05-01" version="1">MDGPPLASLSLTHVYYNPADRVSWVCAWLALVPQALCVVYATLIWSNREIEIFLMFAGQMTCEALNWVLKRYIKEERPKQMHSKGYGMPSSHAQFVSFFSVTLALFLIFRHVPHPTETHTPFSLGGRIVLSLLALLGAAAVAVSRIYLSYHTPKQVIVGCAAGAIFALAWFAFTTYLRRAGWIEWALDTWLLRVLRVRDLVIQEDLVDSGWARWEDRRKRQLFQTQTKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2S9Y1</accession>
    <name>M2S9Y1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_181270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699985.1">
        <property type="nucleotide sequence ID" value="XM_007701795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S9Y1"/>
    <dbReference type="STRING" id="665912.M2S9Y1"/>
    <dbReference type="GeneID" id="19133298"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_181270"/>
    <dbReference type="eggNOG" id="ENOG502RTDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060600_0_0_1"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF14">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="288" mass="33374" checksum="EF66A1D734859B96" modified="2013-05-01" version="1">MDGIFMNRVISPPLAKRRKTTSTAATKNNNKEDSKDEIYPASLRAFLHRHHWLSILFLQEVKIASKDTKTQDAVRTAINSPLLSETSSNTAKGPLYDAYFTLPTDPHNARDPRGSRKVYGVGSILRRDLTNTYTGTVRTVDWDREGRVSIVELTCRATLSKLAIFNIYAVNSTDCLYRDKRSGVVQGTRHDRKREFHRLLMNECKGLEEKDWDVLLAGDMNVAPDERDGYPKLWVFPRDHVVNRANFHDMLLEKSDEEKKTVGLNGIDIWRKMHEQERRYTYYPRNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB43</accession>
    <name>M2SB43_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase PKS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PKS4</name>
        <name evidence="12" type="ORF">COCSADRAFT_357579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700280.1">
        <property type="nucleotide sequence ID" value="XM_007702090.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SB43"/>
    <dbReference type="GeneID" id="19138510"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357579"/>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="entry name" value="ER"/>
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        <property type="entry name" value="Ketoacyl_synth_C"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CARRIER"/>
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    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
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        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="67"/>
            <end position="489"/>
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        <location>
            <begin position="956"/>
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        <location>
            <begin position="2431"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="956"/>
            <end position="1085"/>
        </location>
    </feature>
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        <location>
            <begin position="1096"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="988"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD64523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2516" mass="274105" checksum="72989A0CBEABD1EC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBN4</accession>
    <name>M2SBN4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARS binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007705873.1"/>
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    <dbReference type="eggNOG" id="ENOG502QV85">
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    <dbReference type="HOGENOM" id="CLU_009887_0_0_1"/>
    <dbReference type="OMA" id="GHPHPYY"/>
    <dbReference type="OrthoDB" id="2104370at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018562">
        <property type="entry name" value="ARS-binding_2"/>
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    <dbReference type="PANTHER" id="PTHR42048">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048:SF1">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09441">
        <property type="entry name" value="Abp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
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                <person name="Han J."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SGB8"/>
    <dbReference type="GeneID" id="19141664"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_96183"/>
    <dbReference type="eggNOG" id="ENOG502SPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794512_0_0_1"/>
    <dbReference type="OMA" id="VATWMDI"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39642" checksum="152F0236E83B13A3" modified="2013-05-01" version="1">MDSDSRPKKKRRGGTRSKTDEVNKDAPSLVDVFKLRMNDLELPEDPTPTQSYIPVNSLSPTRSAGPTSPKPKIRLTSESAFLLQTYVRTVATWMDIFDHASTYQHKDYRRHYLGLVSLVKSRRVTAQSTGIDLANFWIYVRHEIVVAMASEQPLVFNPAEWEVSWVEGETREDVLGNHVLWILARVINLVFGPDGNTEVGKIQRQDFLHEMEIWRRGLSETFSGIPHGEKDEDGFCKVYFPVAAAAAAAFWYHIAHILLYAEPVLQDEAYIPLIQEQAIKVTDIAISEFPPSLMVFSTHGLFYAAKHIQGISRKARIWNVLNEVQTQTGYDTRTTVRLLQSLVEQDAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SH31</accession>
    <name>M2SH31_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_39416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702644.1">
        <property type="nucleotide sequence ID" value="XM_007704454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SH31"/>
    <dbReference type="STRING" id="665912.M2SH31"/>
    <dbReference type="GeneID" id="19139492"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39416"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009961_3_0_1"/>
    <dbReference type="OMA" id="CKHPFIK"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="306"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD61715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="689" mass="77952" checksum="99854B7D176FAFA8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHJ3</accession>
    <name>M2SHJ3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_35187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697602.1">
        <property type="nucleotide sequence ID" value="XM_007699412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SHJ3"/>
    <dbReference type="STRING" id="665912.M2SHJ3"/>
    <dbReference type="GeneID" id="19138122"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35187"/>
    <dbReference type="eggNOG" id="KOG1135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002227_3_0_1"/>
    <dbReference type="OMA" id="QSRHNME"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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        <location>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="690" mass="76175" checksum="21318A326AA3600D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKL5</accession>
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        <recommendedName>
            <fullName evidence="16">Myosin motor domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="14" type="ORF">COCSADRAFT_136955</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="Pfam" id="PF08510"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    <sequence length="377" mass="41308" checksum="E7AAA73D7BB14F89" modified="2013-05-01" version="1">MSPQSRGNSMPSGFYSKSTPNLPTLRMYNGESQQDENITSPLRSAPHVDPLSPVSNSAVSETASVEDYQDDYNDDDDDDEGAFAVEDIGSESSGEEEEHAPVSRGLYTSKSYTHLQQHVHTGTALFPPFYNRPPNPLPPSPSLTSLLRPAFSRPTSRPTTPDSSDVDTSRAGSHSNGTSTPTSNTTNLANSARHAPTVPRASPKVPTYEYYGFALYLGSSAAFLMYILWAYVPAPMLHQMGIHYYPNRWWALAVPCWLVVLVIYIYVALASYNTRYLTLPLSSCENLVDDSAQIAAVDKKTGQIVRDPRLLTEKLEDKDKENGSRASAPPSRRGSLSAYQFDASSDVDWKSLWSFGTDAVLDVPIGGVCEILYGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007699210.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SL06"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_112044"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041563_1_0_1"/>
    <dbReference type="OMA" id="AADIWSW"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="434" mass="49252" checksum="043FB4EB553B75EC" modified="2013-05-01" version="1">MVGFTIAMREGAELVGEHGYRYLLVKPLGQSNVWVAVDAATQEKIFIVKQPSDDDVGYGWPRFQHEMVMHELLKGIPTIRQQVDRIPPVSRSDPPRIVLEILQSTLWDARRKRQFSDVEIKGIMRSALLGLRDVHQRDLVYADLKMQNILLSGFEEQPNERAVVGDSKITTKLGDLGIVMEPAKGLVQPIIYRAPEVYFRNEISPAADIWSWGLIYCQLLEAQAAFNKYGIYDELLIGNQGQKERSVERAIAHDFGLGTLDYYDGCRLPYRDNTHYEGQQWDKIVEKGVPEKEVQFLKWVLNPIPTDRPSAQDILNSGWFTTDDQATGRIAETLKTRVEESRRKHLLRKHSEPFLSNMAVQQPVKNTQVPLGVAASTTLPPTPMPQTNEQPVAFEPVSFQPFESSKYYSRPAASRSSTQRPAGGTFMNYGSFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNB3</accession>
    <name>M2SNB3_COCSN</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_331906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700822.1">
        <property type="nucleotide sequence ID" value="XM_007702632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNB3"/>
    <dbReference type="GeneID" id="19137085"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_331906"/>
    <dbReference type="eggNOG" id="ENOG502SQ24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110778_0_1_1"/>
    <dbReference type="OMA" id="RTGVWAW"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD63815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="164" mass="17346" checksum="ACB602425B837BE8" modified="2013-05-01" version="1">MSSNSLNYPLLAIPAYYVFSLIPHGYAGSLLSSNGYKVNNANPKASLSPDAVKGKVPDAVFQKYQRAENAQSNNMEQLPLFAAAVLASILAERTTAVGLGREVVSGDATGLTTFVAAWFAVRTAYVVSYVQIADHATSFVRSSFWAVGSGLAGYQIYKAAALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNC7</accession>
    <name>M2SNC7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_68901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445658">
        <property type="protein sequence ID" value="EMD58292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706046.1">
        <property type="nucleotide sequence ID" value="XM_007707856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNC7"/>
    <dbReference type="GeneID" id="19140453"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_68901"/>
    <dbReference type="HOGENOM" id="CLU_193381_0_0_1"/>
    <dbReference type="OrthoDB" id="5152741at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="82" mass="9427" checksum="13D1A25BB1D46DCF" modified="2013-05-01" version="1" fragment="single">KDDLDEHSALREFIMLVPAQTQEKDSLYQEIRAAVWEGKRSLPSSRKIAISLGDCTINAEDKLCWRNRVWVPECEPLRTGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SND9</accession>
    <name>M2SND9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_185682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705719.1">
        <property type="nucleotide sequence ID" value="XM_007707529.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SND9"/>
    <dbReference type="GeneID" id="19133512"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185682"/>
    <dbReference type="eggNOG" id="KOG1837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001128_3_1_1"/>
    <dbReference type="OMA" id="NDVMWKQ"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="12">
        <location>
            <begin position="1485"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="855"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD58646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1766" mass="195744" checksum="D82908B1CA98DF49" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNE0</accession>
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        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_90707</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700839.1">
        <property type="nucleotide sequence ID" value="XM_007702649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNE0"/>
    <dbReference type="STRING" id="665912.M2SNE0"/>
    <dbReference type="GeneID" id="19141362"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90707"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="RPPNHIG"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD63840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58968" checksum="DD5D51D9A6491A6F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNH3</accession>
    <name>M2SNH3_COCSN</name>
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        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_33605</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695583.1">
        <property type="nucleotide sequence ID" value="XM_007697393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNH3"/>
    <dbReference type="STRING" id="665912.M2SNH3"/>
    <dbReference type="GeneID" id="19137231"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33605"/>
    <dbReference type="eggNOG" id="KOG4513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="6"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD68728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="520" mass="57488" checksum="FC241CEAEDA38732" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPP5</accession>
    <name>M2SPP5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_130664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD69193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPP5"/>
    <dbReference type="GeneID" id="19130795"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_130664"/>
    <dbReference type="eggNOG" id="ENOG502S4MH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126094_0_0_1"/>
    <dbReference type="OMA" id="IVDWNNG"/>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16278" checksum="5A103D482F168E01" modified="2013-05-01" version="1">MFKRLFGEHGAKNVVTLFHAPSNQASTRVLTLLKQANAQSVAHATEDQASSHQAQDKAERTEFELDVTEAPPTTDQLKNILDYLGGPSAAGKVISGAESETDAMRRLKADAATFQRPLVVDWNQGKAVVGENESEIMKLVRSVSKEKDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPU5</accession>
    <name>M2SPU5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_347679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704930.1">
        <property type="nucleotide sequence ID" value="XM_007706740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPU5"/>
    <dbReference type="STRING" id="665912.M2SPU5"/>
    <dbReference type="GeneID" id="19137850"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_347679"/>
    <dbReference type="eggNOG" id="ENOG502S7PV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029042_0_0_1"/>
    <dbReference type="OMA" id="MTCIDEL"/>
    <dbReference type="OrthoDB" id="4205424at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="2">
        <location>
            <begin position="301"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="479" mass="52095" checksum="37FA7E22C523108E" modified="2013-05-01" version="1" fragment="single">EISLTTQNVASSPILSTTNLRFLTTVDTAKIPLYLTAGPSLDVWTTEESTQTWFESLLLSNPITSPNASNHDTNEWWNLARSQSPIGILVQVQDVPESAQKPRTTEILFYGTIAAHAAGGIPTPPSSLSFVDNAGEQLPKLRVHATPLSSDMLHYASIDPPIDNDAHFLPPIHNADAPPRSPKKHRDIFEEATIANKKARGRGGRAVSAAAARGSESQLPYAHRKSSLSIDKRVSPFPDSRPSSSSGPLPHSNSRPLSRSPSISSDTRPLSRKGPPEAHTRRSNLSQVATVPIKPEEPTTESRNKDALVKVVMAAMRMHGLQQRKQNRSRRASLAVAGDESERLSEQATPEEAAKDDEYKLIYHQTYKGAALALRNHMSEKPLHVQPDRMRDVVEKLLVIFLSDPLVEPPPADVPADPVATPGSKPRPGIPGSTHGHASPFDLPSTSRPRMMRSVTDSHVFTGSPVSKKRPTANRPAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ14</accession>
    <name>M2SQ14_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_77506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694685.1">
        <property type="nucleotide sequence ID" value="XM_007696495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ14"/>
    <dbReference type="STRING" id="665912.M2SQ14"/>
    <dbReference type="GeneID" id="19140616"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_77506"/>
    <dbReference type="eggNOG" id="KOG2814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038379_1_0_1"/>
    <dbReference type="OMA" id="LYPFCVK"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="371" mass="40903" checksum="435A9DF0281B044C" modified="2013-05-01" version="1">MGKKKSRSDYNDFLDGEKLRDNTEIRTSLQGSGTQNFSSVPTGQYARGSKKNGKGGAKKPPLTHFLCLPLVTDTSRPQLQEGLDQFEKDLASDSPVPTKAVRPVGTLHLTLGVMSLDAKELENAKQYLEDLDVHTLLRDITHRRIAEKAAEEGIIGENLVPAAMPDTDALTINLEALMPMQALNKTSILYAEPRDPSQRLPLFASALRERFTEAGLLVADTRPLKLHATIMNTIYAKPKRGRGRSKSSKLKHGLKHIEHKVSPHHRHDGDDHHDEGDDDGTSTVGSADGDQDQAQPATGEGHGPDGKSWMRFDATNLVEKYKGFVWARDVRIDRVCICEMGAKKIWSGSHEGDGEILDEQYKAVAVKGIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSA3</accession>
    <name>M2SSA3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_318617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699634.1">
        <property type="nucleotide sequence ID" value="XM_007701444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSA3"/>
    <dbReference type="STRING" id="665912.M2SSA3"/>
    <dbReference type="GeneID" id="19136559"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_318617"/>
    <dbReference type="eggNOG" id="ENOG502QSQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021703_2_0_1"/>
    <dbReference type="OMA" id="NWSDHAP"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37874" checksum="493340475F485439" modified="2013-05-01" version="1">MVFNSPFGASTSKPGHGSIIINLLSQDKPVLGTVSYQYPLKLVAPDPLPPPSHDDQGNSKTGPPIPSLIHTVFLLTYGGGIVAGDSIDLEVKLDSKARLILLTQGSTKIFKTPSPELVSQQHMTVHLKHDSALVYLPDPVQPFAHTAFSQSQIYHLDKGQGNICVCDWVTSGRSARGENWDIFEYKSRNEVWTLDEAGKKRLLVRDNLILDKHGRTGMPLASRMDNYSVFGTVIIRGPVFSSLSKFFLDEFEALPRIGGRNWGDSVQPELLPHEQRRYTRQQREKADGLIWSAANVRGFVLVKFASREVEGSRNWLRDMIKEENSVPRLFGERALLCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST99</accession>
    <name>M2ST99_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_193461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704254.1">
        <property type="nucleotide sequence ID" value="XM_007706064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2ST99"/>
    <dbReference type="STRING" id="665912.M2ST99"/>
    <dbReference type="GeneID" id="19133856"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193461"/>
    <dbReference type="eggNOG" id="ENOG502QVV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008471_0_0_1"/>
    <dbReference type="OMA" id="NSPLIEW"/>
    <dbReference type="OrthoDB" id="5297881at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="659"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="802"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
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        </source>
    </evidence>
    <sequence length="869" mass="94923" checksum="7767CC2074EF31C4" modified="2013-05-01" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="MEAB PROTEIN"/>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU58</accession>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60467.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD66000.1"/>
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    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="219"/>
        </location>
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        <location>
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            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="525" mass="54038" checksum="0B38C15623833446" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="PANTHER" id="PTHR38117:SF1">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="166"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="172" mass="19484" checksum="C0ACF338CF5F31ED" modified="2013-05-01" version="1">MFSLNTTATLRNVTHLPRSISYAQAVEQLHNHELLIRLDPEYASHETLPSDPATPEAKIYKITDHMNALPAGLWDTKVTFEAHMTDLDDGILWFIKAPLGLTQKTTWRCLRTESLEGDRGANEEEGEWSLVEDVEIKANRMLVNTVKGKCEDNWRGTHSRFLAQLKEKIGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVB8</accession>
    <name>M2SVB8_COCSN</name>
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            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_97592</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
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    <dbReference type="EMBL" id="KB445649">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVB8"/>
    <dbReference type="STRING" id="665912.M2SVB8"/>
    <dbReference type="GeneID" id="19141741"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_97592"/>
    <dbReference type="eggNOG" id="KOG0670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_5_1"/>
    <dbReference type="OMA" id="YYNVMLG"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="445"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="775"/>
            <end position="813"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="244"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="406"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <name>ATP</name>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD60996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="813" mass="91079" checksum="E7F6BC5E444AF7FF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2SW37</accession>
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        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_240305</name>
    </gene>
    <organism evidence="12 13">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703506.1">
        <property type="nucleotide sequence ID" value="XM_007705316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SW37"/>
    <dbReference type="STRING" id="665912.M2SW37"/>
    <dbReference type="GeneID" id="19134984"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_240305"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_1_0_1"/>
    <dbReference type="OMA" id="CPLRVQW"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="243"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD61206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="383" mass="42014" checksum="C13C56F6A93FCBB2" modified="2013-05-01" version="1">MPPQIKSDLNRSGWETTDFPSVCEKCLPDNPYVQMLKEDYGAECKICTRPFTIFRWKADRTARQKRTNICLTCARLKNCCQHCMLDLSFGLPIVVRDAALKMVAPGPQSDINRQYYAQEHEKEIEEGRGAMEAYEKTDEKARDLLKRLAQSEPYYKKQRRLETEAGESSGQKALPAPGGSGNGGASAGASRESNHIPGPIRTRDSRGPSARGGMRPGRGGRMGGPPLEPSPQDWLPPSDPNVASLFVTGVEDDLPEHEIRKHFTQYGQLRSLVCSHRAHCAYVNYVKREDAETAAAALKGKVVIKGCPMRVTWGKPKQLDSLDQNVRMQYAKEGRQVAGSSRRAAATSQAAIEAGPQSNLDSMAIAPPPGADDEVQYASLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWD0</accession>
    <name>M2SWD0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_60631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702664.1">
        <property type="nucleotide sequence ID" value="XM_007704474.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWD0"/>
    <dbReference type="GeneID" id="19140376"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_60631"/>
    <dbReference type="eggNOG" id="ENOG502S005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_1_0_1"/>
    <dbReference type="OMA" id="LTVAWTW"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005089">
        <property type="entry name" value="CBM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03427">
        <property type="entry name" value="CBM_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate-binding module family 19" evidence="2">
        <location>
            <begin position="316"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="389" mass="38876" checksum="234E5A4E1084D4D0" modified="2013-05-01" version="1" fragment="single">AALAATVPLSSAHMIMANPVPFNAPNNSPLAPDGSDFPCKGPPSGSAQVNEWHVGSTQSLSFSGTAVHGGGSCQMSVTTDKTPTRDSKWKVIYSIEGGCPANVEGNLDQSGPNYDGTFPFTVPQDLPTGDLTVAWTWFNKIGNREMYMNCASVSVTGGADDASGLDALPDMAIANVNVPGSCGTTKEGTDYTFANPGMFGTTVGEGPFMNLCAGTPSQPGMGRSSGGSGSDGAAGASSQAPAASDAGSAMPSTFRTVKTATAPMLPMPTNPGGVMAPSACSAAQAPKPTPAQPSQGPGTAYPTAAPAPAPAPSHVTPHPSAGLAPGSGSSSGTLCSTDGQLVCSPDGTQYGLCNFGKAVMMPVAGGTKCVSGAIARHDDYTHRNQRTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWQ3</accession>
    <name>M2SWQ3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_344235</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 18"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702763.1">
        <property type="nucleotide sequence ID" value="XM_007704573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWQ3"/>
    <dbReference type="STRING" id="665912.M2SWQ3"/>
    <dbReference type="GeneID" id="19137645"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_344235"/>
    <dbReference type="eggNOG" id="KOG1367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_0_1"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD61406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="417" mass="44575" checksum="14AA8251729C4FCE" modified="2013-05-01" version="1">MSLSNKLSIADVDLKDKRVLIRVDFNVPLDADKNITNNQRIVGALPTIKHAIDNGAKAVILMSHLGRPDGKPNAKYSLKPVVAELEKLLGKSVTFTDDCVGKSVEDTVNSASGGQVILLENLRFHAEEEGSYKDDEGKKQKVDKSKVDEFRKGLTALGDVYINDAFGTAHRAHSSMVGVDLPQKASGFLVKKELDYFAKALEEPKRPFLAILGGAKVSDKIQLIDNLLGKVNSLIICGGMSFTFKKTLEGVKIGDSLFDEAGSKTVKDLVEKAKKNNVKIVLPVDYITADKFDKNANTGYAEDKDGIPDGWMGLDCGEKSIKLYKEAIDEAQTILWNGPAGVFEFDKFAAGTKATLDAAVDAAQSGKIVIIGGGDTATVAAKYGVEDKLSHVSTGGGASLELLEGKDLPGVSALSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXF3</accession>
    <name>M2SXF3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_183596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702909.1">
        <property type="nucleotide sequence ID" value="XM_007704719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXF3"/>
    <dbReference type="STRING" id="665912.M2SXF3"/>
    <dbReference type="GeneID" id="19133422"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_183596"/>
    <dbReference type="eggNOG" id="KOG1514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_1_1_1"/>
    <dbReference type="OMA" id="YEDHPWE"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA replication initiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="79"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="797" mass="88194" checksum="45A21B6D8C9AC667" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY41</accession>
    <name>M2SY41_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phenylacetate 2-hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_148767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702996.1">
        <property type="nucleotide sequence ID" value="XM_007704806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY41"/>
    <dbReference type="STRING" id="665912.M2SY41"/>
    <dbReference type="GeneID" id="19131462"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_148767"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="OMA" id="DPRAYWQ"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD61722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58515" checksum="D93CF4EA57B685EF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYB7</accession>
    <name>M2SYB7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_182988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702201.1">
        <property type="nucleotide sequence ID" value="XM_007704011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYB7"/>
    <dbReference type="GeneID" id="19133388"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182988"/>
    <dbReference type="HOGENOM" id="CLU_707887_0_0_1"/>
    <dbReference type="OMA" id="MPGKNQP"/>
    <dbReference type="OrthoDB" id="3798900at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="420" mass="44521" checksum="208430BB5E37EBD4" modified="2013-05-01" version="1">MAAVGGHNDMLLVLAHRHHLGMTTNTAARIKRHQRTITNKMESKRQRNANLGHGNTDSVLRRNVQSTSSPRLTDPSLVMEGVQKRSLNSRLSSAGQVDTTSTSDSGTPQAAGLVDAAALPGVNQADPGTLSRPMPGVNQADPGRMDGLMPGKNQPPPSIGDTAAAQLLEDMPVSVLCTTFTTYTTLTKTRTDPALTTSESGMGTGFSWPTPAITSISSAASSVTGFPPLPSFSTFILFSQSEEIREQVTASPKSINTPLAITASSALTAVSVPTLQPTSSVVASSATGGSGRGLTPLSRSLFVLFGVLGAITMLIALAIFFMARRNKRRQQLAERYIEENASFEEKKGGALGYGNMTHISTERTDNGPTVLTDSERNIVRRAATQDGQPEVHITAPGARLHDAINSFIAKSRRLTYKISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZ80</accession>
    <name>M2SZ80_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_82785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697221.1">
        <property type="nucleotide sequence ID" value="XM_007699031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZ80"/>
    <dbReference type="GeneID" id="19140915"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82785"/>
    <dbReference type="eggNOG" id="ENOG502TDD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1461045_0_0_1"/>
    <dbReference type="OMA" id="QQGNWED"/>
    <dbReference type="OrthoDB" id="2561193at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="196" mass="22211" checksum="98F01BE1EA0115FB" modified="2013-05-01" version="1">MTRSNYSAFQKHLLFFSTPTTPPRLTFKSALRAGVSLGLDFPVAVLLSVSLRILYAPFPYFWSPIIVDKIPASSHRTQLENATLPQGKTNYTCSELLSLSQQSENGGRNKAWLSHKIDQGHIVGFWTMAANTRSHTVSKEDVERFQQGNWEDAVVERRRGRNDVLPLWRGGPIWTGGHSWAVRRTLNVRVYETKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2T036</accession>
    <name>M2T036_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_38337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701595.1">
        <property type="nucleotide sequence ID" value="XM_007703405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T036"/>
    <dbReference type="STRING" id="665912.M2T036"/>
    <dbReference type="GeneID" id="19139229"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38337"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049471_0_0_1"/>
    <dbReference type="OMA" id="IAYIMVM"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="87"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="320" mass="35981" checksum="9F255A1EEE58F04F" modified="2013-05-01" version="1">MATFREEAAMSDHPNVHMRNQHEYTYRLPAPPRIAVPPPTLVSDMPGLVLSDSSGEELDMTFLKELDLEHIVHKNSLLEWAYERRRQAQMILPWLYLGPMMAAKDKAFLEREGITMALAVRAQPNSLVGAMQAASEVCLEVGSIEALTFYALTPKFPEATRMINTHVAKVRQHTLQTKGEATLGKVLVFCESGNEKSAAVVAAYLMETLNDFNHVRAMQICQAQRFCSNFDDTLKNILRSYWDIVGARRAIAASQYQTPHRNVQSNGHPQPDSLSPTLSSSKPKRSLEEMRDEDADMDSDVEASDALRFADRDVTPFQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0X1</accession>
    <name>M2T0X1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_37758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700983.1">
        <property type="nucleotide sequence ID" value="XM_007702793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0X1"/>
    <dbReference type="GeneID" id="19139077"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37758"/>
    <dbReference type="eggNOG" id="ENOG502SB54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065618_3_0_1"/>
    <dbReference type="OMA" id="NQTMSSA"/>
    <dbReference type="OrthoDB" id="5589325at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025996" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD62866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="229" mass="22757" checksum="34381E886B95960C" modified="2013-05-01" version="1">MRFFQAILSSAAFAALVAALEINEFPTQGVVAGNSYTITYSPADDVPTTFILRQGKSTDLDTVGTLTTTATGGKFQWTPSKDLPNESDYALEIKRGDTVNYSAQFPLTGGAASDDKPVSSSSPSASASASSSVKPSSLASSSASPSSSASGSSSMTSAASSTPSASVSTPAGNSTISSATLSRTPLPSATRTPTGSASVPEVTASGADSLFANPLAAIVGAAAALVYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T144</accession>
    <name>M2T144_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_37812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701000.1">
        <property type="nucleotide sequence ID" value="XM_007702810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T144"/>
    <dbReference type="GeneID" id="19139094"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37812"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OMA" id="PKPFIEH"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05362">
        <property type="entry name" value="THN_reductase-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD62931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="270" mass="28902" checksum="14D9BDE8991C452D" modified="2013-05-01" version="1">MPHVESTPSTYIPGRLDGKVALVTGSGRGIGAAVATHLGRLGAKVVVNYANSTKDAEKVVSEIKALGSDAIAIKADIRQVADIVRLFDEAVAHFGHVDIAVSNSGVVSFGHLKDVTEEEFDRVFSLNTRGQFFVAREAYRHLTEGGRIILTSSNTSRDFSVPKHSLYSGSKGAVDSFVRIFSKDCGDKKITVNAVAPGGTVTDMFHEVSHHYIPNGLEYTAEQRQQMAAHASPLHRNGFPQDVANVVGFLVSKEGEWVNGKVLTLDGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2T150</accession>
    <name>M2T150_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_162300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702035.1">
        <property type="nucleotide sequence ID" value="XM_007703845.1"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </feature>
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        <location>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="771"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700729.1">
        <property type="nucleotide sequence ID" value="XM_007702539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T398"/>
    <dbReference type="STRING" id="665912.M2T398"/>
    <dbReference type="GeneID" id="19133736"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_190892"/>
    <dbReference type="eggNOG" id="KOG2848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_10_0_1"/>
    <dbReference type="OMA" id="MPRPLCY"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="111"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="309" mass="34014" checksum="9E14A90F551B72FB" modified="2013-05-01" version="1">MSWPLYLAMPAVLIVAMRLLSLVLPAKPAQLLSYYAFAASSFILMGFCALYGTLVAIPLRIIGYGGLIQWSVGRAFKWCMWYGTGVTFRITGSMKKEGGVSGEDALKDRPAVFVGNHQTELDVLMLGCMFPKYTSVTAKKSLKYTPLLGWFMALSKTVFIDRANRTTARAAFDTAAQTMRSTRQSVFIFPEGTRSYASTPDLLPFKKGAFHLAVQAQVPIVPVVCANYSHVLNVKEQKFQPGVVDVTVLPPIQTKGLGAEHVDDLVKRTRDAMMDELIRLSHISGAGNGEPLPRTSGIDQSRSELRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3U5</accession>
    <name>M2T3U5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_118835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700718.1">
        <property type="nucleotide sequence ID" value="XM_007702528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3U5"/>
    <dbReference type="STRING" id="665912.M2T3U5"/>
    <dbReference type="GeneID" id="19130396"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_118835"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_4_1"/>
    <dbReference type="OMA" id="MNQGRWD"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="264"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="954" mass="108455" checksum="A895E7CA2416A897" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4B7</accession>
    <name>M2T4B7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_181258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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            <strain evidence="12">ND90Pr / ATCC 201652</strain>
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    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        <property type="match status" value="1"/>
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    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD64676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="184" mass="20349" checksum="F4D640841B5CE846" modified="2013-05-01" version="1">MAAAPPPPPQWVVDLNSTPASKPKNPALIDPPGYTASLTKKERSQASKNQRVSPTADEMDTLKMKKAWEVAIAPAKQLPMNAFGMYMTGNTLQIFSVFMVFTLFKTPVLAVLGLQRTFAPYQTPGTAGRLLGVKLVYIACNLLMLALGIWKVNAMGLLPTTRSDWLAWESERTWSERAVPQEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6E7</accession>
    <name>M2T6E7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_37112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699872.1">
        <property type="nucleotide sequence ID" value="XM_007701682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6E7"/>
    <dbReference type="STRING" id="665912.M2T6E7"/>
    <dbReference type="GeneID" id="19138900"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37112"/>
    <dbReference type="eggNOG" id="KOG0856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_1_1"/>
    <dbReference type="OMA" id="DKHMPES"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="77"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD64537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="204" mass="22471" checksum="250491E9AF9CEEF5" modified="2013-05-01" version="1">MRFPSFPTFLRTIHTVTNTTTAFLRSSPTTGIGRTIYNTPQRAVLYRSMPNIPFLGALFGSSSSMSDNTNYSVQKPEGEWQAQLSPEQFRILRKKGTEPPGSGKYDKHYPDAGVYTCGGCDAPLYKANHKFDSGCGWPAFWDAIPGAVGQKPDPGLGMMRTEIVCNNCGGHLGHIFKGERFGNPKDERHCVNSISINFSPEDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8I6</accession>
    <name>M2T8I6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_139035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698477.1">
        <property type="nucleotide sequence ID" value="XM_007700287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T8I6"/>
    <dbReference type="STRING" id="665912.M2T8I6"/>
    <dbReference type="GeneID" id="19131113"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_139035"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OMA" id="CRFWAGP"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026205" description="FAD-binding domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="429" mass="47457" checksum="DB8445D790D64D1D" modified="2013-05-01" version="1">MSVRLDVIIVGAGLSGLAAAIQCALSGHSVTVLEATKELAEVGAGLQLTPNATRLLQQWSVYDTIGDQVCEPTTLTVYNYRGEALAHEDNFGTNIRRKYGAPFSDCHRVDLQQTLVRRARELGVHVVLDAKVNGMDFGSAPGDRARVKSYQGQTYEADLIVGADGLWSFCRSTMLGRNDPPLPTGDLAYRIVLSVDQIGDPKLKEMVQTPACRFWAGPDAHAVAYSIRGGNMYNVVLLVPDDLEEGVARTQGNLDEMRRLFEGWDPVLTQLLECVDRVDKWKLMHRAEMDSWVSPQNNLVLIGDSCHPMLPYLAQGANSSIEDGAVLGLLLAPEHYKSRSQLPETLQLFQQLRKARSESIARETFKQRKDFHLRDGPEQAIRDATMLGQLGKSPEGAFPSRWTCPEVQPWLYGYNATEEVAAAMRARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9L1</accession>
    <name>M2T9L1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_86419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698947.1">
        <property type="nucleotide sequence ID" value="XM_007700757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9L1"/>
    <dbReference type="GeneID" id="19141108"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86419"/>
    <dbReference type="eggNOG" id="ENOG502SMK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_25_6_1"/>
    <dbReference type="OMA" id="VVINIWI"/>
    <dbReference type="OrthoDB" id="4525788at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD65931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="438" mass="49071" checksum="182C21EE9364D7DA" modified="2013-05-01" version="1">MQLPPASVVLSWPTPNYDDPVTRGPALIIVNSVFITLTFLILFAVCLTIVVLLANKSYGWDRHVWDIPISNFVPTYKIAMTAKVVFTAAASFTRLSLHCFYYRLVSDSGKSWFRWLVHFNVFYTISCFVSFTCIAIFFCVPISNYWTLGAPAETCLNEADATLIVGIINCVADLLTTVTPIPLVMGLQMPLHQRLAVAFFFGMGFIVTAAGIVRTWFIYRSLYNEWDQTWYAYPLWIAAAVEIDLGVMCASAPVLKPLLAKIPWSLSGALTGGLSFKKSSLHTSKTLTTSQSAAFMSKRRSTAPQSVPELMYDKGHSYEMKNWEDAGTRHSNTDLERGSQETGSEDEERPKNGTTRWLEKLRTKTTSTRNSEDMTITLTSQVELKSEPAALRDGSASRYRSFHENHMPLDENHMPLPPSRPGRAASTNDQIRQSNSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9M1</accession>
    <name>M2T9M1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_311224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698957.1">
        <property type="nucleotide sequence ID" value="XM_007700767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9M1"/>
    <dbReference type="GeneID" id="19136389"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_311224"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="OMA" id="TAPNYWH"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="333" mass="37380" checksum="BDF4DD140268C94F" modified="2013-05-01" version="1">MPLIAQNPKDRVILGLMTFGPDESSGARITEFDEFTKHLDYFQAQGYDEVDTARMYVGGRQEAWTRQAGWKDRGLTLATKVYPFEAGVHKPENLKKHFTTSLQELGADCVDIFYLHAPDHSVPFEETLEAVNELHKQGKFVNLGLSNFAAWEVAEVYNICKERGWVKPTIYQAMYNAITRAIEPELVPACRKYGIDIVVYNPLAGGLFSGKIKSKDIKPDEGRFGTKADGIGTMYRDRYFKDATFEALKIAEEAAQKHNLTLLEIALRWCVHHSELKTRVKGGNDGVIIGVSSLKQLEGNLADLEKGPLPDDIVKALDEAWMVCKATAPTYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9T2</accession>
    <name>M2T9T2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_140480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Han J."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Steffenson B.J."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.29" evidence="3"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697862.1">
        <property type="nucleotide sequence ID" value="XM_007699672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TBY1"/>
    <dbReference type="STRING" id="665912.M2TBY1"/>
    <dbReference type="GeneID" id="19132621"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_169302"/>
    <dbReference type="eggNOG" id="KOG0776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_1_0_1"/>
    <dbReference type="OMA" id="AFDYYLH"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD66347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="374" mass="40850" checksum="BAAC76211595C9DA" modified="2013-05-01" version="1">MDPFQTVAREMKFLTGNIRQLLGSGHPTLDTVAKYYTQSEGKYVRPMLVLLMSRATALTPHRNIARGGIGSQSADISITNPSILADENPDTSPISSIRHDSAYTPEDSDILPSQRRLAEITELIHTASLLHDDVIDHSVSRRAAPSANIEFGNKMAVLAGDFLLGRASVALARLRDPEVTELLATVIANLVEGEFMQLKNTARDEKNPIWTEETVSYYLQKTYLKSASLISKSCRAAAILGGSTPDVVEAAYLYGKNLGLAFQLVDDMLDYTVSEAELGKPAGADLELGLATAPLLFAWKENKSLGKLVGRKFSEQGDVQQARQIVAQSSGLEQTRALAQEYVDKAIDAISFFPDSEAKTGLVEMCTKVMKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCD5</accession>
    <name>M2TCD5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_84517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697960.1">
        <property type="nucleotide sequence ID" value="XM_007699770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCD5"/>
    <dbReference type="STRING" id="665912.M2TCD5"/>
    <dbReference type="GeneID" id="19141015"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_84517"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_0_1_1"/>
    <dbReference type="OMA" id="ENATVCC"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD66477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="187" mass="20238" checksum="8CF151A34E7EC063" modified="2013-05-01" version="1">MGMGNGCKISMLWNWNVVDACFITKAWHIRSKGMFAGSCIGVILLVILLEFLRRAAKEYDHFIVMQHSKTLASDTAALSSASSADGIAPGTSKNPGPVGTASPTMGGGVKAKFRPTILQQAVRALLHTCAFAVAYFVMLLAMYYNGYFIICIFIGAYIGYFIFGWESFTVSKGGDDRMQENATVCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDM2</accession>
    <name>M2TDM2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_303133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <location>
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        <location>
            <begin position="666"/>
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            <begin position="735"/>
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        <location>
            <begin position="669"/>
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        <source>
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    </evidence>
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</entry>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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    <dbReference type="STRING" id="665912.M2TE68"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_290169"/>
    <dbReference type="eggNOG" id="ENOG502S442">
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="202" mass="22426" checksum="F08A39AE2C19C016" modified="2013-05-01" version="1">MESIDTFTLLPLELDPATHSIIAPQNTSNVVEKELEALNNLHRNLLHVETPTGTPPPPVPVNPKRSAQIGKLRENGNAEFRKGNHDAAAKMYTLAIDMALARPAWEPSGLVREELSGLLSNRAQANMAQQKWAEGGIDAEASVEMKKVGNAKAWWRRGKCLLEMGRLDEAETWVKQGLEFEATEQDLVSLKEEIERKIRGKA</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Dhillon B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
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    <dbReference type="CDD" id="cd22997">
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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    <feature type="chain" id="PRO_5004025972" evidence="1">
        <location>
            <begin position="18"/>
            <end position="577"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67932.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="577" mass="64993" checksum="F72FC51B4ACEB269" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI88</accession>
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                <person name="Henrissat B."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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    <dbReference type="AlphaFoldDB" id="M2TK56"/>
    <dbReference type="GeneID" id="19137487"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_341569"/>
    <dbReference type="HOGENOM" id="CLU_161482_0_0_1"/>
    <dbReference type="OMA" id="CHTPAIP"/>
    <dbReference type="OrthoDB" id="10314795at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="154" mass="17163" checksum="48CC3C7695C3BD53" modified="2013-05-01" version="1">MLRRGSLLATTPTREPCMFPRQERRLDLSIPSNIGFPYTISHSSPFRYRALRAAIDGLLTSNPHVCYLTHPRQQKKMPPRVKKRTDNGDVVLQLNRWVLHASWTPLHPPISVIGSAGETGDLECTPPCHTPAIPCIQHDAYSVSVHVRVGADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2TL05</accession>
    <name>M2TL05_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_214285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695042.1">
        <property type="nucleotide sequence ID" value="XM_007696852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TL05"/>
    <dbReference type="GeneID" id="19134461"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_214285"/>
    <dbReference type="HOGENOM" id="CLU_2346376_0_0_1"/>
    <dbReference type="OMA" id="ELWRIHK"/>
    <dbReference type="OrthoDB" id="3704005at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="97" mass="10890" checksum="5F17941A111BB52F" modified="2013-05-01" version="1">MSSTRIFHNISRIPVTSTLVLIFGNYELYRIHKGTHPYWSPILEEKGIVRRRVQNASESTGGQSAPGVESQREGRKASIQWLNLNGVPIPFITGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TL25</accession>
    <name>M2TL25_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_131094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694723.1">
        <property type="nucleotide sequence ID" value="XM_007696533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TL25"/>
    <dbReference type="STRING" id="665912.M2TL25"/>
    <dbReference type="GeneID" id="19130812"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_131094"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OMA" id="FPEGCFQ"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="468" mass="51622" checksum="36A395E1F90D8FE8" modified="2013-05-01" version="1">MSLEKITTISPITNKPIVTRNGLSDADLQSLPETAATAFESYRRTPLSERQAIVKKALKLLNERQDVLGKEITEQMGRPIAYTAKEVSTAVMRGEYLLKISDETLKDTDGEPEKGFKRYIKKVPLGPVLILFPWNYPYLTLINSLVPALLAGNSVILKPSPQTPTSAEQIQQIFKEAGLPDGVLQIFHCGSVTQIESIARSLKIQLVCFTGSVANGLAIQQAANDRVPLRIGLELGGKDPAYVRSDVDVKWAAEELVDGAVFNSGQSCCSVERIYVDEKIHDEFVSALQEVLKGYRLGDPFDKNTHVGPVVSKRSAETIREHVKDALEKGAKDATPENATFQNPPADGNYVAPTLLTNVNHEMVVMTEETFGPVIPVMKVKNDTEAIKLMNDSQFGLTASIWTKDVNKGHELADDVEAGTVFVNRCDYPAPDLAWVGWKDSGRGQTLSRFGFDQFVKLKSYHVKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLU1</accession>
    <name>M2TLU1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_217376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695261.1">
        <property type="nucleotide sequence ID" value="XM_007697071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLU1"/>
    <dbReference type="GeneID" id="19134523"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_217376"/>
    <dbReference type="eggNOG" id="ENOG502S73P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027352_0_0_1"/>
    <dbReference type="OMA" id="AGIWTKQ"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049511">
        <property type="entry name" value="PGH-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17660">
        <property type="entry name" value="BTRD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026070" description="Beta-lactamase-related domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="317"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD70131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="644" mass="70999" checksum="9998816295AD1285" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLZ7</accession>
    <name>M2TLZ7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_342377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695317.1">
        <property type="nucleotide sequence ID" value="XM_007697127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLZ7"/>
    <dbReference type="GeneID" id="19137538"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_342377"/>
    <dbReference type="eggNOG" id="ENOG502T77U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_765054_0_0_1"/>
    <dbReference type="OMA" id="VKHHERE"/>
    <dbReference type="OrthoDB" id="3794120at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="205"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD70211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="362" mass="41101" checksum="059BA2AB7C683823" modified="2013-05-01" version="1">MTTPYTTPPGSSERRTSIGETSNPIVISSPIPQLKPFKPHQMLMQAPVAIECSPDLSIKFTIHEELLRCHSKLLEECFTKAKILRKQFEQTDHLRDQIAAHVFPEVTAEEFAAGDHEEKALPLIIRAYERFPMPGYGPAIKKLINNATQAEVQSKRVKTCMLHDAIREDNTKVRLTYIDAFGLHAITEKLFAAIHRINKREITRAKDKKRILILEAEPDTVQSVMDWIYQGKVEFEDPQQLYNTLQLATQLDVRALSEFCHSELYNTAKDHIEDAVANGTSLKTMLGYGPGPGDRIMKVVFKHAFKDHDTPKRLREMVINTLASNLNAELWTEIKDVVSHGMALQIIEAMLEYQEQVEEGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLZ9</accession>
    <name>M2TLZ9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_21903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694079.1">
        <property type="nucleotide sequence ID" value="XM_007695889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLZ9"/>
    <dbReference type="GeneID" id="19134550"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_21903"/>
    <dbReference type="HOGENOM" id="CLU_1299497_0_0_1"/>
    <dbReference type="OrthoDB" id="10434260at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="243" mass="25531" checksum="E65112137820B8CA" modified="2013-05-01" version="1">MAAPCPWAPTSLRASHRTDIVACCYPVIVAVVVVVVVVVVVVVVVVVAVTVAMHTRHPLDMCLREPLRLDPATDRQSPVAGRPIAAVAATAAKCFRLKCLPDLLMLIAESPRPELALVSLVSHSVVSTACPCCVCAPQSPPSALDLLASWCPTTAIDGASQEEPYHYHQTSPIFHGPCFPSTPLAKPPGAQSPTYPVTASSGLAPAVTTLWALLVSLWAKQRQTIASVKTASSPTRAVLKLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2QTP4</accession>
    <name>M2QTP4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_165363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705647.1">
        <property type="nucleotide sequence ID" value="XM_007707457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QTP4"/>
    <dbReference type="GeneID" id="19132382"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_165363"/>
    <dbReference type="HOGENOM" id="CLU_2468918_0_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="88" mass="9729" checksum="11AA6A820EFE5211" modified="2013-05-01" version="1">MPLAQGKNKSRDESVDEIFRSSTNATKAALAVLLTTEAMAEVVVIALGLPGLFTTCIESFELIQYAKTFEDDRRDLVLRLEILEARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2QV32</accession>
    <name>M2QV32_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_31149</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705202.1">
        <property type="nucleotide sequence ID" value="XM_007707012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QV32"/>
    <dbReference type="STRING" id="665912.M2QV32"/>
    <dbReference type="GeneID" id="19136392"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31149"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_1_0_1"/>
    <dbReference type="OMA" id="QIPAQKD"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="111"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="11">
        <location>
            <begin position="508"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD59004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="576" mass="64419" checksum="A2CE8A9BF261E497" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2QV57</accession>
    <name>M2QV57_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_194415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705463.1">
        <property type="nucleotide sequence ID" value="XM_007707273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QV57"/>
    <dbReference type="GeneID" id="19133893"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_194415"/>
    <dbReference type="eggNOG" id="ENOG502S5VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051118_0_0_1"/>
    <dbReference type="OMA" id="YREALMF"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF4">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="2"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="209" mass="23333" checksum="C2509D2B51D0B8C8" modified="2013-05-01" version="1">MDLVLEVRQKLKEYREALMFERTLASLGPPPVRTFDAINHAAIRYDKALEQREPIMIGSSAKLYTTNEDLVVLKQSEFEDRLTSFVQRYLPVFFMAERRDDNMAYIPEKRIARFVTVLGILITVILLFVAILALYFILNPTVKLIMVGVFMLLFAGSVGLFTTAKRSEVFAATAAYTAVLVVFVSGNLGSDPWLSGLWSGGNCTCTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2QYZ9</accession>
    <name>M2QYZ9_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_30272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704042.1">
        <property type="nucleotide sequence ID" value="XM_007705852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QYZ9"/>
    <dbReference type="STRING" id="665912.M2QYZ9"/>
    <dbReference type="GeneID" id="19136211"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_30272"/>
    <dbReference type="eggNOG" id="ENOG502SKYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_2_2_1"/>
    <dbReference type="OMA" id="PVFHMAG"/>
    <dbReference type="OrthoDB" id="2932980at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050197">
        <property type="entry name" value="Aldolase_class_II_sugar_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789:SF0">
        <property type="entry name" value="3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789">
        <property type="entry name" value="FUCULOSE PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD60249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="279" mass="31052" checksum="C63D5CC02DF69C17" modified="2013-05-01" version="1">MSIPPALQQQLRLLIRANHILHHHGLVDAFGHISVRHPLNKDQYILAAYDPGAPALVKNVSDFNSYWVRDSSPVDKDAPQGYSERFIHGEILRKFPKANCVVHSHSEDVIPFTIAHGAAHPHPVRPVFHMAGFLGQGGASVFTMDRLYGTSRAPTERDLLIKNAELGEALAAQLRMESPVVLQHKHGFTTFGISIEEAVYRAIYTQKNCVLLQRAIAIAGGDAEAVQYLSSEEIKDCAVMNGKTLDKSFRLWLREVQVNRLYQNDEGEPEKGKVAGMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZA3</accession>
    <name>M2QZA3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_163719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703749.1">
        <property type="nucleotide sequence ID" value="XM_007705559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZA3"/>
    <dbReference type="STRING" id="665912.M2QZA3"/>
    <dbReference type="GeneID" id="19132264"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163719"/>
    <dbReference type="HOGENOM" id="CLU_112101_0_0_1"/>
    <dbReference type="OrthoDB" id="3692536at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="168" mass="17973" checksum="EA16321FDB9E7FC2" modified="2013-05-01" version="1">MPPKAQPPPRGIWANEDIRRVFDYFCRPRGNSPYDAVFGPGPYDYSPVIARTTITARQILTGRPSYLKAFVVHSRGALNATFYTNNCAAVLRGEKEFTAFAGCVSIAGEWGGACSNCVWQDYGARCSVTQQTVSRTGGGRKRLSGGSSSGSQRGCPAAGGAENLLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2R1U7</accession>
    <name>M2R1U7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein rho2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_240501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703521.1">
        <property type="nucleotide sequence ID" value="XM_007705331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R1U7"/>
    <dbReference type="STRING" id="665912.M2R1U7"/>
    <dbReference type="GeneID" id="19134988"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_240501"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="NDNVMRR"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD61229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22565" checksum="D4F9EF57B400011B" modified="2013-05-01" version="1">MAQQQQNGEPVMRRKLVIIGDGACGKTSLLSVFTLGYFPTRYVPTVFENYVTDCRVDGKSVQLALWDTAGQEDYERLRPLAYSKAHVILIGFSVDSPDSLDNVKHKWAEEARERCPTVPIILVGLKKDLRDDPLAQEEMRKKSLRFTTTKQGSDMKDMIGARKYLECSSLTGDGVDDVFEAATRAALLSVDKKENPGCGCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8L5</accession>
    <name>M2R8L5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Checkpoint protein RAD24-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_38147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701088.1">
        <property type="nucleotide sequence ID" value="XM_007702898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R8L5"/>
    <dbReference type="STRING" id="665912.M2R8L5"/>
    <dbReference type="GeneID" id="19139182"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38147"/>
    <dbReference type="eggNOG" id="KOG1970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006397_0_0_1"/>
    <dbReference type="OMA" id="YNKREDP"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="509"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="720"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="805"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD63284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="879" mass="94751" checksum="474CFEC1D6F78FD4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8Z5</accession>
    <name>M2R8Z5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_171679</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <property type="nucleotide sequence ID" value="XM_007701654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RC56"/>
    <dbReference type="GeneID" id="19138872"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36995"/>
    <dbReference type="HOGENOM" id="CLU_062261_0_0_1"/>
    <dbReference type="OMA" id="SSYFYQH"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41446" checksum="14E9787B43AF4B7B" modified="2013-05-01" version="1">MAEFNDMPAEIRNMIYEPLLSQSHSQNTVERLRSNNAFSLFTVSKQIHDETTSYFYQNNNIKIYTPSQTTETATILPPIADRYLRFLGRVRVLATIATAESTTHTKVAGTIASLANIGAKFEDVHIFINSSLSRLVNKMVDDSILDADHPIIVALQKLLGSGVAEVVRLSLPGAWLTPSVAQHLKSQYGDRILFIGRDGSPCDAACIEKSKTGVHVTRHMATLGLDKEAMEHAYSDDEDEFDQPTPSSVPSSFGSALADLDTFSVTRYETSPEDAKNDDSTGDSAGGDSFFSEADLEEWATSGENGVQEEPSQPEDVDVDDDELDEELDDMSDDGFDTIMGNMDDMAHHIANEADITYLVNFAPELLQVGHNLDHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RE15</accession>
    <name>M2RE15_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_180983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699534.1">
        <property type="nucleotide sequence ID" value="XM_007701344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RE15"/>
    <dbReference type="GeneID" id="19133274"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_180983"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OMA" id="TYVIDCH"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001500">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="526" mass="56959" checksum="AAE06ECBE5723C10" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJ33</accession>
    <name>M2RJ33_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_85062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698140.1">
        <property type="nucleotide sequence ID" value="XM_007699950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RJ33"/>
    <dbReference type="STRING" id="665912.M2RJ33"/>
    <dbReference type="GeneID" id="19141039"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85062"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OMA" id="TWIWIDS"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="248" mass="28402" checksum="CC5DC72C131B2C8C" modified="2013-05-01" version="1" fragment="single">MRLLNTESLELSRPYVPGKVPDYAILSHRWSTEEVTFADISSTPILHPQSQTRTKKGFAQIQGVCKLALNDGYTWIWIDSCCIDKSSSAELQEAINSMWRYYAESNICYVYLADVPDSEAGWGLMFAKSEWFTRGWTLQELIAPTCVEFFAENWSAIGTRFERYKEIADTTSIDPDVLLRVHPVDSFSAAERLSWASHRNVTREEDEAYSLLGLFDVNMPLLYGEGREKAFFRLQEAIYNATADHSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2RPZ3</accession>
    <name>M2RPZ3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">COCSADRAFT_274863</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696188.1">
        <property type="nucleotide sequence ID" value="XM_007697998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RPZ3"/>
    <dbReference type="STRING" id="665912.M2RPZ3"/>
    <dbReference type="GeneID" id="19135685"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_274863"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016428_4_0_1"/>
    <dbReference type="OMA" id="PHYYARA"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="387"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="573"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="99"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EMD68639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="760" mass="85951" checksum="0D20418DABF4B432" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSE3</accession>
    <name>M2RSE3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_341479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694812.1">
        <property type="nucleotide sequence ID" value="XM_007696622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSE3"/>
    <dbReference type="GeneID" id="19137479"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_341479"/>
    <dbReference type="HOGENOM" id="CLU_1447420_0_0_1"/>
    <dbReference type="OMA" id="GWGRHAD"/>
    <dbReference type="OrthoDB" id="3689292at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="225" mass="24675" checksum="DDD671CB367FB0F9" modified="2013-05-01" version="1">MRTLGGFAGLSCTAPDLTDAISARRAEEDLGKIPNKKVSGAKTKYTIPGLIVDAARSHRACLYELTSLQSSRTFSFASALCHCTMGMRLLKGDIHLQPPSVSVFTGRSAFGSAPRQHSQNMSYVSELGRAFDLFNNSSTLADKHFMQPILDGFRLHLGFEDRFQPWLRALSARQRATQRFASSSNRSSAGERGGWGRHADAHVQHDLTSPSRRPSLPPTNPVWCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXJ7</accession>
    <name>M2RXJ7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_347420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704757.1">
        <property type="nucleotide sequence ID" value="XM_007706567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXJ7"/>
    <dbReference type="GeneID" id="19137840"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_347420"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="OMA" id="IGCGMEA"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF17">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD59783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32313" checksum="21BE0FECB9847906" modified="2013-05-01" version="1">MALVHLASRGEANFDLFPYNPSIGAGYAYMVMFGIMAIAHIVLMFIYRSWYFIPFILGCIGESAGYYGRAWAHDNIRNGTPYLIQMMLILGSAPLLAATVYMTLGRLARNLDADEYCLIRSTWISKIYIVIDIASFGCQMAGSAAQASGPEGAKQGISIVKIGLSIQLVAFGLFLVMAVVLDTRLRSSPSSVSERPHVNWKKHFLALYAVSGLIIVRSLFRLIEFAQGPDGPILKMEWMMYVFDASLLLASTVCFAIIHPGRLFRYIRKVDGSPFVKSDDGHMPLNKYARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZ17</accession>
    <name>M2RZ17_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_30291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704044.1">
        <property type="nucleotide sequence ID" value="XM_007705854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZ17"/>
    <dbReference type="GeneID" id="19136216"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_30291"/>
    <dbReference type="HOGENOM" id="CLU_1834977_0_0_1"/>
    <dbReference type="OMA" id="NCHAFIF"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="174" mass="19602" checksum="5313AE1589CF15D9" modified="2013-05-01" version="1">MAADANGRSLLGNRARPELARTVKFPSLIRAEHGYGFHSVDRDVLDAARLDRTQIDAYIAALEGAVTAGAYTEEQLAKDRLNFATVDSTTVPEENLLHPSEDIKPAAKLEFAFQYYQEQEAKVASTEGLTRRHFLPGHLWILTETVDISGRVRYFSMQPSVVFNRHAFIFDKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2S078</accession>
    <name>M2S078_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_245123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703949.1">
        <property type="nucleotide sequence ID" value="XM_007705759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S078"/>
    <dbReference type="GeneID" id="19135098"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_245123"/>
    <dbReference type="eggNOG" id="ENOG502QPHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
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        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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        <location>
            <position position="70"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
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        </source>
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        <source>
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        </source>
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        <source>
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            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="182" mass="20043" checksum="39A44E6D1D12FE20" modified="2013-05-01" version="1">MGGYLSTFTKLIWAKKEIRILILGLDNAGKTTLLYRLKIGEVVTTIPTIGFNVESVTYKNLNFNVWDLGGQTSIRPYWRCYYANTAAVIFVIDSTDIERLTTASEELRAMLNEEELRDAALLVFANKQDQPGAKGAGEISEALRLGDLKDRNWSIVACSAVDGSGVQEGMDWLVSNVGDGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_96143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502S5RK">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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    </feature>
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        <location>
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            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="348" mass="38979" checksum="55B565A4578384A0" modified="2013-05-01" version="1">MKLRMIFSCTILLIVTAFGQFINNEQVMSVSDSGLEGKLLDSSIVQDGPPVESSAAGPEPFNPALGADFDPDVFASNQLWEGYISKGSYLFCLMIASGETAGRLMGTPRTPPSASSPWVMDDIIRGTYKFAVNVRDGVTIARQTLSPRTAVRHPFSWGREVRPDELPELQHVTDIHWGFWIKNNPNIKNFRGYGVENVVNDHTVLLVTRALRNRRKFALEIWPGVMFEKGSEEYMALIGSPIGDTIANFLITHKPWLGLKHVTHVIVVCDGNDQDTCARGMNKMHLFFTVEDAHFENEEGIEGNEGNRETGRIESHVFHVRDDGKQVVREHKVTANLWDEVNAWGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2S3A7</accession>
    <name>M2S3A7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_233894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702944.1">
        <property type="nucleotide sequence ID" value="XM_007704754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S3A7"/>
    <dbReference type="GeneID" id="19134830"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_233894"/>
    <dbReference type="eggNOG" id="ENOG502T5Y0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535255_0_0_1"/>
    <dbReference type="OMA" id="NRCEATF"/>
    <dbReference type="OrthoDB" id="3695726at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="496" mass="54748" checksum="19EC9A68DE1A3052" modified="2013-05-01" version="1">MMPEIGSGFDEVDWPEHQHPHQTLLSMGAQSAEGTVAQHTNQYWAPYPEDRRERAPVEHWGQNGHPTSTHSQHHVVFEGYSAEQSPSRAANRNPGSFRENTAYSVNGPHHAYRTMENRHEPLMPVHSRTYYQDESAPNAYHGAHMQPEFLLRAPSSFPNSVHGAANNAYAANLDTLSHLGAHVIHEDTCRTPKSSSSDLQYQQYYGQEPETPIDPTLDQEQGSFSMTESTLGPWSSPQGGIVVQLDAPDSEPWNAVGLMDGSQTTRSTRQIQAGVDRMTLRATRSMSAYGDPSSVSSMRSGFETLLSSESPYFPQSSAPASQMDVFDSYKFPLGIDCTSGPRTNSRNRHWLKVEGAATPTRTRGHLERYPHSDPGRYLQLPGKRRASSASSQITEATSSSAVSGLGQGVLKCGVNRCEATFSGRYGKGNRARHKKDYHGGKEPVICEDSSCGKIFRRSDARLKHYRSRHPHLVGINKQVSRPGRRNPAPGDLDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2S423</accession>
    <name>M2S423_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_38732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702100.1">
        <property type="nucleotide sequence ID" value="XM_007703910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S423"/>
    <dbReference type="STRING" id="665912.M2S423"/>
    <dbReference type="GeneID" id="19139327"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38732"/>
    <dbReference type="eggNOG" id="KOG0880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="OMA" id="ENHEITH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006532033" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="208" mass="22823" checksum="052C02B23BEFD7D5" modified="2013-05-01" version="1">MASFQKAVISLLLILSITFVFFVQTTEAAKSPKITNKVFFDIEHGDEKLGRVVIGLYGKTVPKTTENFRALATGEKGFGYEGSTFHRVIKDFMIQGGDFTKGDGTGGKSIYGEKFPDENFKLKHTRKGLLSMANAGKDTNGSQFFITTAITSWLDGRHVVFGQVLEGYDIVEKIENVQKAPGDKPVKTVKIAKSGELKVPAEGIHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2S5A6</accession>
    <name>M2S5A6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_42659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S5A6"/>
    <dbReference type="STRING" id="665912.M2S5A6"/>
    <dbReference type="GeneID" id="19140182"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_42659"/>
    <dbReference type="eggNOG" id="ENOG502SQ1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_4_1_1"/>
    <dbReference type="OMA" id="DEYSHRT"/>
    <dbReference type="OrthoDB" id="5428863at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="52"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="271" mass="30606" checksum="9D78834932A64B04" modified="2013-05-01" version="1" fragment="single">NFQLVREWLEICKTSHKHDLAGPRGKECVPGFKVIDCRTKRIIPVPHNVCQYVALSYVWGDAAPEDHKAGQYPKTIEDSITVCNMLGFECLWVDRYCINQKDEAEKGVQINMMDCIYSQAQLTIVATDPNPSKGLPGVGSRARNKQQSLPLGNIELIKTYHTDEAILRSTWATRGWTFQEGYLSRRKLIFTENEAVYLCDDMYCQESIRKDISTRPTGQRQGLAGAAMDGICPMSTNERKGQVKLDDLLNEYNSRDLSYQSDALNACQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2S663</accession>
    <name>M2S663_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_342924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S663"/>
    <dbReference type="STRING" id="665912.M2S663"/>
    <dbReference type="GeneID" id="19137571"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_342924"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OMA" id="CIGRHMA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF162">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD62603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="506" mass="56481" checksum="44DCC57503C4DB41" modified="2013-05-01" version="1">MAVISFLQELSIGQQIGTAAAIFIFVLTSIVVYGCYLHPLSHVPGPFLAKFSPIWGMRALYRMKFNSELQALHEKYGPVVRVAPNEVSFATLEAETAIYANQEDGRFSKAGTFLTLFSDLVLNAPTLITIPDPALHKRLHRVIQQAFTPQALASQEPIQKLHIEKAIPDFDETAEKGYNIDLADKLETMFWEIIGDLAFGEPLMAGKRPTYETLKQLGKGSMPMVEALSFMLVMPGVAPTLEMARSFLSAMPMSSQLSKLVPSKKLRDCIERKDGREDFLSAIMGSEKQGLTLDADAFFSNAMGLTLAGYQTTATTLASTFYHILRYTDAYKTLCTEIRSAFNNEADITGERLARLPFLNACIRETLRLLPPANGKTAQRAAPSCTIADTYIPAGTIVSADLYTIQRSEKYFVDPARFHPERWLEGAEKNGFNGDNKSASRPFLIGSRACIGRHMAQQSIRLIMATLLWRYDFELLDRDAFIWERDAGSSLIYTDYKLPVHVKRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2S703</accession>
    <name>M2S703_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1772 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700998.1">
        <property type="nucleotide sequence ID" value="XM_007702808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S703"/>
    <dbReference type="GeneID" id="19139092"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37809"/>
    <dbReference type="eggNOG" id="ENOG502SW17">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127761_0_0_1"/>
    <dbReference type="OMA" id="VAWWERV"/>
    <dbReference type="OrthoDB" id="3648235at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20012" checksum="5821CE112FD6BC50" modified="2013-05-01" version="1">MAALDTAFYIIPFIHWGMIVSLFIVSGIAWSFNLWVVPIIKLNPSKSAIAQLLETSRRGGAWLEPLNASFAFLFGITAALLSQHSDTSVASQWKPFAASFATLLQVAWWERVMIFPLEESIANLGKGKEKSGGAEGAWMDHETSKVLHKSLDEWSRWHAVRATLPLIGSLIAFVTKLQNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37284</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007702195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S850"/>
    <dbReference type="GeneID" id="19138945"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37284"/>
    <dbReference type="eggNOG" id="ENOG502T0NB">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2386056_0_0_1"/>
    <dbReference type="OMA" id="NCMDICT"/>
    <dbReference type="OrthoDB" id="4843554at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024802" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10981" checksum="402A4D0879210A34" modified="2013-05-01" version="1" fragment="single">MRYNTIAIAFALSAVGLADKLEFEDVPRNCMDICTPVVNLTTGCDDRGPNDNDFAERQCICNAQNANTQIPNCADCIWRNGGEFDNGMSFLLFLLLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">Glycoside hydrolase family 16 protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">COCSADRAFT_102490</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007707205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8M9"/>
    <dbReference type="GeneID" id="19129803"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102490"/>
    <dbReference type="HOGENOM" id="CLU_826361_0_0_1"/>
    <dbReference type="OMA" id="KGTATHI"/>
    <dbReference type="OrthoDB" id="3791536at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025132" description="Glycoside hydrolase family 16 protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37045" checksum="C49D0448D965AE75" modified="2013-05-01" version="1">MKSRIAALASAIAYFTFANAEVAPEITIVAEGYNVIAKVPCVECPFLYQDTSKGNDAPWTQRKDANALLLNISLPYDSAHLNINNAALLTNNKILPRIYANQVLEDIPTDDVATLISSNQLDNLGGSYFGASYSYTLARVKDEPKALLFQFDIMELWTDLTSPPLTVFLDRKEQKIVELVLMQRPLLSPGDPAGAYEIVKVHLIERPPARTRGVKGPRKVSMWFHDWDANGKKGTATHIVNSASESFVNYISSGVWALLVFVFAVIALFVLICFFVIFGCGWWNENDYEIAQHGKKNKSNNSGRAKDIEAARRFLSPEELGLRGSGRVVGVGKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2S9P9</accession>
    <name>M2S9P9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_41138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704859.1">
        <property type="nucleotide sequence ID" value="XM_007706669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S9P9"/>
    <dbReference type="STRING" id="665912.M2S9P9"/>
    <dbReference type="GeneID" id="19139917"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41138"/>
    <dbReference type="eggNOG" id="ENOG502R6ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021857_0_0_1"/>
    <dbReference type="OMA" id="AYYINTF"/>
    <dbReference type="OrthoDB" id="3796651at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
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            <end position="54"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD59270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="636" mass="70550" checksum="8470CFF47BC96E03" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699967.1">
        <property type="nucleotide sequence ID" value="XM_007701777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S9T4"/>
    <dbReference type="STRING" id="665912.M2S9T4"/>
    <dbReference type="GeneID" id="19136638"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_320770"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038964_1_0_1"/>
    <dbReference type="OMA" id="FRKEVCH"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
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        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
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    </dbReference>
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    </dbReference>
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            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="388" mass="43276" checksum="6F8F3DEB7816CE94" modified="2013-05-01" version="1">MDTIESDSSVPVAGDSVFSISRPSSASSIRSADTPKELPAGAPVSHLFQVRHTPTAGRAVFATQDIPKGTLVWQSTDLTLSVLLREYRREVCGQCFGYDYGRGLSIRDKTVGFAFCSEACQKTWQEEQGEIGIQTWTAVENLIRKRSKEDSDMVDVDMPRPTKKDISKAWDSVAGQAALIRSAREAEQADGVDCQAAVAISKQHKKAVSKALQGRITPDVMSFCVSGILWRHHHPEQWERLEALANDNTPYHSSDDLDAFTRAYLHLVAILPVALLPLVTAETLLTLSKRDSHNSFGIRSLEDEGSEFFGYGCWPAASYFNHSCGQNIEKKREGRIWYFRAGRNIEKGRELCITYLSGEERMLSRGQRMLRLKKTWGFDCGCERCGAL</sequence>
</entry>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59550.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="19135222"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_251320"/>
    <dbReference type="eggNOG" id="ENOG502SQUK">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_067855_0_1_1"/>
    <dbReference type="OMA" id="AIHGPWY"/>
    <dbReference type="OrthoDB" id="4158987at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="145"/>
            <end position="241"/>
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    </feature>
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        <location>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD59550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="241" mass="25048" checksum="90DD56DD64B684EA" modified="2013-05-01" version="1">MPPKKLNQQTPSVPEDELKNIAAKSDSPEDKLKQAAASAESALASAKTASSLRAAAETIKDPTKREKYLRDAYEKEIEAHGNSKKARMLSSGAFQGSVGGGGIGMAVGAGLGTVVGTLVGTVATIPTTAVGTLVGAGVGGVHGPWIKLGGKKGEKDSDGNDVKKAEGEDGEDDTKEKKVDEEMEEQMAGEEDGIPDPEALRRAAEEISRQRKEKEGGEGGDGGVKEKKKPRKLEVRSKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB20</accession>
    <name>M2SB20_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_190582</name>
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    <organism evidence="3 4">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="19133724"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_190582"/>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703028.1">
        <property type="nucleotide sequence ID" value="XM_007704838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SE71"/>
    <dbReference type="GeneID" id="19135993"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_29083"/>
    <dbReference type="HOGENOM" id="CLU_986984_0_0_1"/>
    <dbReference type="OrthoDB" id="10574091at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="282" mass="29050" checksum="0E5CEB81F68C8D81" modified="2013-05-01" version="1">MPAVAGWLGRCAWRGLSTQQEPMCPGASLLCFGDGDGGHQDAKPTNRSLMAISTTVTSGPFAMREKKNRAAAAVELLPPTTGGPRKRQTFTVGVGERGPRPMTYDYTTTCCTSAAQRDLCTSIPKPEHHGGGDNVGGESGLGWDADGMGMGAAGGWASSTLHSTPTASASASSPPTACATAIVTRSPQALGTSFWARCNCISKCPPCPLGMHVSVFEAGHLLHPAPPTASPCVAGHWLLAAPSPWLRSLLAHGHGNVWLQAPHDSPGSHSAATRTPWAIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M2SF25</accession>
    <name>M2SF25_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_115094</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698914.1">
        <property type="nucleotide sequence ID" value="XM_007700724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SF25"/>
    <dbReference type="STRING" id="665912.M2SF25"/>
    <dbReference type="GeneID" id="19130268"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_115094"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="OMA" id="MINVHDI"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF346">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="975"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1012"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="93"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD65888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1138" mass="123425" checksum="C7ADC169D3DF0A7E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFS3</accession>
    <name>M2SFS3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_344052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702676.1">
        <property type="nucleotide sequence ID" value="XM_007704486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFS3"/>
    <dbReference type="STRING" id="665912.M2SFS3"/>
    <dbReference type="GeneID" id="19137638"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_344052"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_14_0_1"/>
    <dbReference type="OMA" id="PAYRVMK"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32594" checksum="62E6A6CF668CEEE4" modified="2013-05-01" version="1">MGFKDGEKLRFDNRIVIITSAEGEPTKETVVLITEAGGNAIAAFGSVADRKTCEAIVTTAIKQYRRVDVLIKNAGIEIKKPFEDMTVDDLSRMLDVHVMGSWHLPQLLWPHMKLAGYGKIIMVCSSSLFGIPYNSAYVTAKGALYGLMRSLSYKGREFGVKVNCLVPVAFTQMTKVIAHEFQWNFVAQSMPAWTTSPVCAWLAHEANDDTGEMISTYGCSIGRMFFAETKGFCCETGEHTIEIVKSHYEAARDKAGYIVPTSVEDENKRLEGYIECYPREAFNHLFITARIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SH35</accession>
    <name>M2SH35_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_112995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697989.1">
        <property type="nucleotide sequence ID" value="XM_007699799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SH35"/>
    <dbReference type="GeneID" id="19130202"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_112995"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="QPLFWTF"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="508" mass="55573" checksum="72604B3848D3339B" modified="2013-05-01" version="1">MSSFFTKRYYASNSQDEEKIDTVAFEKDGDGIPDAPVIGKIDPVIAKRVRRKLDKHVVPLLAALYLLAFLDRSNIGNARIAGMEEDLHLSSSEYSWLLTIFYISYIVFGFLIVMWKVVPPHHWAAGCVFAWGLISSAQAGAQSWTGMMVLRFLMGVAEIAFGPGVPFLLSFFYLRHELGLRCGLFLSAAPLANTFSGALAYGITSGNPSFAKWRVLFLAEGLPTVVMSVVTWFFLPDSPEKARFLTEEEKAVAKARGVVQAGTGTRIGSIEWKEMLEAVLDLKSWVLGIMYFSGNVAFSSLPVFLPTILTEMGFSHVNAQGLTAPPFFVSFLTVIVTCYIADRTQQRGIMIAILTAIGGAGYVILATTKAVAARYFGVFLAAAGIFPAIGNVLPWITNNQGTDTRRGTGLMMANLIGQCGPVLGTRLYPKSEGPLYVKGQSICAGFMFLFCLLAILLRTLLAWENKKLDKQYGTLAQQKSAMQEAAKGGEAVHQIGLENYGPMYRHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SI63</accession>
    <name>M2SI63_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_23354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696417.1">
        <property type="nucleotide sequence ID" value="XM_007698227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SI63"/>
    <dbReference type="STRING" id="665912.M2SI63"/>
    <dbReference type="GeneID" id="19134824"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_23354"/>
    <dbReference type="HOGENOM" id="CLU_094267_0_0_1"/>
    <dbReference type="OrthoDB" id="5407715at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="216" mass="23363" checksum="83B425F38453ACDD" modified="2013-05-01" version="1">MSTHKALVLEKFGTPLVLEDISNPTCYTWLSARCTALRDDTPATSSAVVWCFQGASYSCVARILSLPPDATTLQIGDLVWVDATIRSRDNPHAEVVRASLCGADPGSLTLVKSVWKDDVFTEKLLVPLEARNAEKLELLERYHGAKERLSTVILTGDTDVDAKALKDATGGKGAHAFVDYSPSSLKEEPPFSMAGIKSFKRGGEYILLGGAYVDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SII3</accession>
    <name>M2SII3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_351596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696776.1">
        <property type="nucleotide sequence ID" value="XM_007698586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SII3"/>
    <dbReference type="GeneID" id="19138100"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_351596"/>
    <dbReference type="eggNOG" id="ENOG502RXYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124027_0_0_1"/>
    <dbReference type="OMA" id="HLEWNHY"/>
    <dbReference type="OrthoDB" id="5394233at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="189" mass="20472" checksum="DB7AAA9DFC1C5501" modified="2013-05-01" version="1">MPFDFDAYDKKCSQMSPEELHLEWNHYTRLISGAAASATLGGSALVFTGGVSIIGVAIGSAGFYNARKKRQILKRHLDREHRTNRKRDIVGSAAFNGAVGLTTLGLGTLGAEKVLELGIENGVFGRAAETGVKVATGVVVNGVNTAADDRYHTHKKKREAKRACLAVERKHEDGQKKRSTRVLGSINQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIR0</accession>
    <name>M2SIR0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701568.1">
        <property type="nucleotide sequence ID" value="XM_007703378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SIR0"/>
    <dbReference type="STRING" id="665912.M2SIR0"/>
    <dbReference type="GeneID" id="19139202"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38225"/>
    <dbReference type="eggNOG" id="ENOG502S2WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_2_0_1"/>
    <dbReference type="OMA" id="FEEHDPC"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="240" mass="26993" checksum="0BBD77C766681D8D" modified="2013-05-01" version="1">MTKSASFDVIGTCFGFSAPIQAIHSRLGPKLKTADVDPKTLFFSWFYAAQRDFTYVSMNGSYVPIAQILKSTLRRACAVVDLPTDAVTDEDLEEIMKAFRSMGPREDLKKCFDGLREAGWEVYGVTNGGSETSLNYYHSAGIELDADHLLSCDAIQVAKPDVRVYENANQHISRRLQGKEEGERWFVAAHAWDLIAARKVGFKTAYLTFEEHDPCTDVFGEFDLYAPSMDELLHKLKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJ40</accession>
    <name>M2SJ40_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_121006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701775.1">
        <property type="nucleotide sequence ID" value="XM_007703585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJ40"/>
    <dbReference type="STRING" id="665912.M2SJ40"/>
    <dbReference type="GeneID" id="19130471"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_121006"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013227_1_0_1"/>
    <dbReference type="OMA" id="WALGRRF"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="206"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD62390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="824" mass="92378" checksum="4BAB6FECF78F4EE4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SK71</accession>
    <name>M2SK71_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_290571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697197.1">
        <property type="nucleotide sequence ID" value="XM_007699007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SK71"/>
    <dbReference type="GeneID" id="19135985"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_290571"/>
    <dbReference type="HOGENOM" id="CLU_2305582_0_0_1"/>
    <dbReference type="OrthoDB" id="10333803at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025073" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13238" checksum="26D76966CAB6CC45" modified="2013-05-01" version="1">MIQRGGPMLCGLFWSCGGWRCWNICNQGEPHGGITEVVCVCRESGWQWSQMCMCSPWTCLSAYRSGILLWCTQDMASGLRDYKLARLASKGRRRLHSENDNDEFVSHQRELRCMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMK7</accession>
    <name>M2SMK7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_190768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700615.1">
        <property type="nucleotide sequence ID" value="XM_007702425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMK7"/>
    <dbReference type="STRING" id="665912.M2SMK7"/>
    <dbReference type="GeneID" id="19133730"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_190768"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OMA" id="CSEADHA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="496" mass="56213" checksum="8B390394822FBB00" modified="2013-05-01" version="1">MSHILNMLAFSAFGATSLVLFKVLYNIFLHPLRHYPGPKWWAATRLTWSHSLQSGTYHLKLAQFHKQYGPVVRVAPDELSYIDPEAWKDIYGNRNIPKNRVWAGQEEEYRPISIVSTDEATHLRNRRALAGAFTEHAITEHAPLLEGLVETMMQKFAEAAKQGDRSAIVDFTDWFNWLTFDISGVLSFGESFGSVAAGRAHPWVEISCSFGKGIALMASINFFRPLDKLLKLAMPRGVMEKMKYHKELAHAKFMQRLAMEHKEKAQDYVGSILAYNQEKGETKISDEEIEMNMTVLIFAGSETTSTSLTAILTQLLQNRAALTKVVTEVRENFTKEEDINIASMGKLAYLDAVIQEGIRMGPPVAVGLPRITPKEGEIIYGQYVPGNTFISVNQYPTFRSALNFTDPDLFVPERFLPNSPYPSDRIDAFVPFLLGRHKCMGQKLAWAIMRLTLAQLFFKFDLEAAGQVDDFGLQNNYMFWEKRALKVKIRPRGGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN33</accession>
    <name>M2SN33_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_75403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445670">
        <property type="protein sequence ID" value="EMD58187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706108.1">
        <property type="nucleotide sequence ID" value="XM_007707918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN33"/>
    <dbReference type="GeneID" id="19140517"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_75403"/>
    <dbReference type="HOGENOM" id="CLU_206083_0_0_1"/>
    <dbReference type="OrthoDB" id="3686619at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="52" mass="5991" checksum="67C996293364FDC0" modified="2013-05-01" version="1" fragment="single">MATPNEKPIKKPKMATPDKYDGNREGLRTFLTTIELYCGYNDVPNDEEKILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN58</accession>
    <name>M2SN58_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_190936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700776.1">
        <property type="nucleotide sequence ID" value="XM_007702586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN58"/>
    <dbReference type="STRING" id="665912.M2SN58"/>
    <dbReference type="GeneID" id="19133743"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_190936"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_25_2_1"/>
    <dbReference type="OMA" id="PDECSLW"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="Zhong S."/>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPQ9</accession>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700130.1">
        <property type="nucleotide sequence ID" value="XM_007701940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPQ9"/>
    <dbReference type="GeneID" id="19131249"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_142645"/>
    <dbReference type="eggNOG" id="ENOG502SJNU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041041_0_0_1"/>
    <dbReference type="OMA" id="ICPERAT"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="78"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD64300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="391" mass="43082" checksum="7A7F98586099B4CC" modified="2013-05-01" version="1">MLSPPLSTRSSFESLHSNTSSVLSSPDRLPPAVNGPMVWQGKELDPSEYVVRLSEGEIRDVRAAIIKFKLTGLSRSDISPETFDLGNAQLANKLSSLSKRIHHGRGLAVLRGLDTAYFNDEEAVIAFAGICSYICPERATDSYANQTLSHVLDATKKPVPVECRGIGLAGSKVTSAMDFHSDRFSGDVLALYVRNDGGPNAGGEQFVASFARIYNELLETDPEVLETLAEPNWPFELKQKNGAAYLSYGPILFFSLNGMPICQLVKAPLLGTPSLPRAAHLPSLNPQQLHALAAVERLAREYSHQLCRRQGDIQLVHNLSIMHARSAYGSSNAQSSRHLLRMFVRDPACAWEKPRWAATSFDDPFEKGRPQNLPVYDMDPWRIISGRESHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPU6</accession>
    <name>M2SPU6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_208038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694638.1">
        <property type="nucleotide sequence ID" value="XM_007696448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPU6"/>
    <dbReference type="STRING" id="665912.M2SPU6"/>
    <dbReference type="GeneID" id="19134355"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_208038"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="OMA" id="INVSYNC"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="11">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="103"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="550"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD69253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="670" mass="74625" checksum="A58583B51B4A069F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPZ9</accession>
    <name>M2SPZ9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_36953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="68" mass="7770" checksum="8B28AE40F10300B4" modified="2013-05-01" version="1">MALPPPLSVAVRLWLFFLLAAIMSSYVNPLGQTTHRLPLPAHLLLWQPCHRRRLLEALCFSRILPDVV</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
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    </reference>
    <comment type="cofactor">
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            <name>FAD</name>
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    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704344.1">
        <property type="nucleotide sequence ID" value="XM_007706154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSU1"/>
    <dbReference type="STRING" id="665912.M2SSU1"/>
    <dbReference type="GeneID" id="19134247"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_203146"/>
    <dbReference type="eggNOG" id="ENOG502RGYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_0_2_1"/>
    <dbReference type="OMA" id="TYINFAH"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025949" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD60131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="472" mass="50241" checksum="E900859720A6DB58" modified="2013-05-01" version="1">MKVLSLLVSFAAAVSALALKQRDVASDLKNLVPGSSVNVEVKARWSDFNAPLPSVTVTVQAEDDIAKIVKYCTKAGISFLTQNGGVGWGKTFKLGEWGVLIDLAGLNSVTVAADKNTATIGGGASIGDVIASADAAGALVITGNCNCVGALGAMLGGGYGNLMGEVGFGVDNIISMRVVTAAGELLTASATSNSELFWALRGAGPNFGIVVSATVNARPATAEDRTAFINNLFFSPDKLEQVAQAVEDLPLTPEQRVYLVLTSSGPPLNEPSILVTGFLRKGTLESGRKAFAPFYDLGPLSDSSIVTTYDHWNDANIGFCTRGGRKPTFSSTIKGMNAQKWPQIWDLYKSFQAKGPNSAMLIERYNLTKAQSAPVGSVALNEALRRDAFAQALVIPWYDDASLDAEALDFGSKVRALWSRSSDPKNDPTYPNFAFGDETNKAIYGSSLPKLQTLKKKYDPKGQFNQWFPIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST83</accession>
    <name>M2ST83_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704079.1">
        <property type="nucleotide sequence ID" value="XM_007705889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2ST83"/>
    <dbReference type="GeneID" id="19139734"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40420"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_1_4_1"/>
    <dbReference type="OMA" id="CKVTAHD"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="367"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="632" mass="69439" checksum="73DF2B7966ED69E3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU20</accession>
    <name>M2SU20_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_40212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703638.1">
        <property type="nucleotide sequence ID" value="XM_007705448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SU20"/>
    <dbReference type="STRING" id="665912.M2SU20"/>
    <dbReference type="GeneID" id="19139671"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40212"/>
    <dbReference type="eggNOG" id="KOG2940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046586_0_0_1"/>
    <dbReference type="OMA" id="YEVVYGH"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="118"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD60576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="354" mass="39347" checksum="4F476DE627BBBE30" modified="2013-05-01" version="1">MAGFSVRALISPCRRQCFSRQFTRRYAVQAPGAPMLEIFSAQQKWMQKERAAKDVETSRNVDYLRNEVASRLCERVLDINRHFPKVLDLGANACNLSRALTLPSEDAPEKGPRSKRIGTITAADSSRSLLYRDADLPFNKEIDIVREVLPTSELLPYEANTFDAVLSNLSLHWINDLPSVLAQINNVLKPDCPFIGVMMGGDSLYELRTSLQLAELDRRGGVSTHTSPLADVKDVGGLLQKAGFNLLTVDVDDIVVDFPDTFSLMKDLQAMGESNAVMAREKGAIHRDVLLAAEGIYKELHGNEDGTLPATFRLIYMIGWKPSLNQQKPLERGTGMFSIKDYLEKNGESGEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUU7</accession>
    <name>M2SUU7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_62509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697645.1">
        <property type="nucleotide sequence ID" value="XM_007699455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUU7"/>
    <dbReference type="STRING" id="665912.M2SUU7"/>
    <dbReference type="GeneID" id="19140398"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_62509"/>
    <dbReference type="HOGENOM" id="CLU_179711_0_0_1"/>
    <dbReference type="OMA" id="WHRKHKK"/>
    <dbReference type="OrthoDB" id="3693645at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="102" mass="11813" checksum="890650C4BE2F89C4" modified="2013-05-01" version="1" fragment="single">MSTPSNLGLRRLVEYDKRNSPLLSLSNAPTVGDTTSEAQADELVTIYADFPNDGDDDYDGLDFKRVPYLERRQVERSSRGGPKSWIYRHGWAVWHRKHKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUW6</accession>
    <name>M2SUW6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ribosomal protein subunit L20-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703640.1">
        <property type="nucleotide sequence ID" value="XM_007705450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUW6"/>
    <dbReference type="STRING" id="665912.M2SUW6"/>
    <dbReference type="GeneID" id="19139673"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40218"/>
    <dbReference type="eggNOG" id="ENOG502S0A4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089054_0_0_1"/>
    <dbReference type="OMA" id="CSQFFVG"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25002" checksum="61176374D03635F6" modified="2013-05-01" version="1">MATCKPLLRVCPSTLQPASLLPRTQQRFESTTRRHRKLLALPAAPSYTPDTSSPTLIFNPPSSAPSIHHTPLKFLPQTDKRRNLYASAHQQLARTALSTRTSPIASPGTPLQSSSYLPPKPSTSLPPPVRQPYEKQYHLTEKEVTEIRRLRAQDPDTWTRVKLAERFGCSQFFVGLVAKNAGKAERVAREQEGMREKWGTRRREAREDRGRRRVAWGRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SV68</accession>
    <name>M2SV68_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_295842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697746.1">
        <property type="nucleotide sequence ID" value="XM_007699556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SV68"/>
    <dbReference type="STRING" id="665912.M2SV68"/>
    <dbReference type="GeneID" id="19136073"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_295842"/>
    <dbReference type="eggNOG" id="ENOG502S9TE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_657457_0_0_1"/>
    <dbReference type="OMA" id="AWYPAYI"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF4">
        <property type="entry name" value="PITSLRE SERINE_THREONINE-PROTEIN KINASE CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="46019" checksum="1CD69C692F1994E6" modified="2013-05-01" version="1">MSISDNSTLGVSHEQDGMGECLHGFGDLAISAEEKSPYASTHIAVLEVGPEAVRFLVHESVLSRSEVLARSYNPSFIKQSVPLPELDLATAHTLVHYLYTGKYQTLSVHAGSDKIIPESYKLSVCVYCAAVRYGLPGLAELAQGKIKSFGEDVTIFDMLAVARQHAFPLLPEDDAWYPAYIEDALRNAVTDDPNPFRKPDFITTVEGSSRLLQLVWKTMMSNYVPKPATPTSTPTVKADSVAARTPELVPDISESHGNVGSAIAIESEDASNSKPEAVAEPHSIVEEPDKNALVVESVQDVSGEVGATASNPQFLAMPESFTDDQEFVTSMKWQQMHKKAEQEAPITVSPKEEPKMTSLVRTDSVTQLEQMAGASNLKTTAGNDASAETGQASASASEVVPVKKGKKVKKMKSAKKSAAQAEPVVASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVV6</accession>
    <name>M2SVV6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_149664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703444.1">
        <property type="nucleotide sequence ID" value="XM_007705254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVV6"/>
    <dbReference type="STRING" id="665912.M2SVV6"/>
    <dbReference type="GeneID" id="19131505"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_149664"/>
    <dbReference type="eggNOG" id="KOG2629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045718_0_0_1"/>
    <dbReference type="OMA" id="YNQWQPP"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000489">
        <property type="entry name" value="Putative peroxisomal membrane anchor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD61126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="367" mass="39183" checksum="44D09C8F7DF63E79" modified="2013-05-01" version="1">MVREDLIISAVSFLQDPSVASAPLEKRIAFLQSKNLTQEEIDVSLARAAEDAGQPPPPQTSAVASNASYRPPPAAPYASYPPQGYWQPPPPPPEPPKRDWRDYFIMATVMGGVGYGLYFTAKRYVLPLIQPPTQPQLEQDKASVDESFKRAFDLLEQLNTDTTALKASEEARTARLDDALGEVESVLSTLKESSKRQGDDNRRIEDDVRGLRDLIPKALESHKEATDNRLKELSTELKSLKTLIGNRMGSAAPRPQNASGYYGAGQQPSAPQTPNVNGTSSVSTPTPQAPSTPAPAPAPAPAEQANGTSVADNQANGLATPSASYSSRMPTGRAAIPAWQMAAAKKTEEAKKDTSESGTAVEASASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWM0</accession>
    <name>M2SWM0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_169590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698110.1">
        <property type="nucleotide sequence ID" value="XM_007699920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWM0"/>
    <dbReference type="GeneID" id="19132639"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_169590"/>
    <dbReference type="eggNOG" id="ENOG502SG78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110315_2_0_1"/>
    <dbReference type="OMA" id="YWKASTW"/>
    <dbReference type="OrthoDB" id="5285218at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="79" mass="9089" checksum="E15ADEC891400962" modified="2013-05-01" version="1">MGIFEKLQARLELHRLEQRYTRREKRTTFISEAQYVDGEYVYASSPSSAKSSSTINSKRFSVMPSIRIKEIGRNGTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXS6</accession>
    <name>M2SXS6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_39461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702654.1">
        <property type="nucleotide sequence ID" value="XM_007704464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXS6"/>
    <dbReference type="STRING" id="665912.M2SXS6"/>
    <dbReference type="GeneID" id="19139502"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39461"/>
    <dbReference type="eggNOG" id="KOG4068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087657_0_1_1"/>
    <dbReference type="OMA" id="TRCLIMW"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD61756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="211" mass="23218" checksum="153F3985292E5C0D" modified="2013-05-01" version="1">MATTSSYLPPVPNPTSTSTSSNTSFTFPPHYSFPPFFTLQPVASTRSSQLASWSTLIQSYCRHHRIFTLSLIDALPTPLFTNATLRRSLSLRDAKAILTYMASPEGGNRAEFITSGTKKSSKAEEGEGGKVWVYWRRPEEWATAIEEWVERTGQKGTVLTLYEIVEGDAVGKEEFGGMDMELLQKSLGVCVKRGKAQVFGSGGEGEGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXV5</accession>
    <name>M2SXV5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_96999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702923.1">
        <property type="nucleotide sequence ID" value="XM_007704733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXV5"/>
    <dbReference type="STRING" id="665912.M2SXV5"/>
    <dbReference type="GeneID" id="19141714"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_96999"/>
    <dbReference type="eggNOG" id="ENOG502QV67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514823_0_0_1"/>
    <dbReference type="OMA" id="TAWDDIM"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF9">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025911" evidence="3">
        <location>
            <begin position="18"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="529" mass="57268" checksum="25571F29F4C17B9C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY50</accession>
    <name>M2SY50_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">COCSADRAFT_188039</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696958.1">
        <property type="nucleotide sequence ID" value="XM_007698768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY50"/>
    <dbReference type="STRING" id="665912.M2SY50"/>
    <dbReference type="GeneID" id="19133613"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_188039"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="OMA" id="FGIDDYI"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="940"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1028"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EMD67255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1086" mass="117523" checksum="D67759706732D781" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZE3</accession>
    <name>M2SZE3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ornithine aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_183259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD62142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="665912.M2SZE3"/>
    <dbReference type="GeneID" id="19133402"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_183259"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40665" checksum="FC79CDDDDA0CC68F" modified="2013-05-01" version="1">MHGFDHLMQKGPRQLVVFDSGDGAFLKDVMGKRYLDAIGGIVVAYLGYGRKDFAQVAFEQMTKLEVSSNQRNLTNNNAVKLCERLSGLVAQAFPDKMTAPATFIPVSMKPEFSDYGWKRWMEGYGRDFYESSSHRMFCNIDLPHELFFERSKLKHGENVGQAAARELEERILQEGADTVAAFVFEPVQGDGGAIDMHRDFFLLVERICRKYGILMIADEIMSFAKTGHWFGHPVCSVVALRALDIIDRENLIELCAKRRREFLDILKSELEGLHTIQQVRGTGIMIGIDLISDIATDIEQKVLLEYGIVLRASTNKHCMLLKPPSSMTEEHFKKVAESLRKGLRSFVTLGESAISKSHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
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    <name>M2SZJ4_COCSN</name>
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        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_34518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696634.1">
        <property type="nucleotide sequence ID" value="XM_007698444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZJ4"/>
    <dbReference type="STRING" id="665912.M2SZJ4"/>
    <dbReference type="GeneID" id="19137695"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34518"/>
    <dbReference type="eggNOG" id="KOG0772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014033_2_0_1"/>
    <dbReference type="OMA" id="KGDQYIT"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000868">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="61667" checksum="3EC2DA1E4CA8CC68" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZM1</accession>
    <name>M2SZM1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_229233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD62217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZM1"/>
    <dbReference type="STRING" id="665912.M2SZM1"/>
    <dbReference type="GeneID" id="19134741"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_229233"/>
    <dbReference type="eggNOG" id="KOG2399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004979_2_0_1"/>
    <dbReference type="OMA" id="ARAHFHI"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="816"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="846"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="881"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="911"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="957"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="113"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="848"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="676"/>
            <end position="749"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="722"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD62217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112044" checksum="AC892ED1D273E779" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZX2</accession>
    <name>M2SZX2_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_179433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZX2"/>
    <dbReference type="STRING" id="665912.M2SZX2"/>
    <dbReference type="GeneID" id="19133198"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_179433"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_13_2_1"/>
    <dbReference type="OMA" id="GVYLHIH"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="99"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="334" mass="37131" checksum="345CA3475CE63939" modified="2013-05-01" version="1">MTLKSDVTVDASKFDRSTIDKQTLEFNDKLIKIWADGPRWYEVGAAEYRKMRWEGKTPLPKPIVLPEGVNGALPSREAGREIPYRVFKPSSGKSNGIHMHIHGGGWVLMSEAYQDPYLKYMADHFDVTVVSIGYRLAPEDPWPAGAEDCYDAAEWLVKNGPTVFGGELMFTGGESAGGHLACLVALHLLETMPEFAFKGLLLHFGCFDMSSFLPHVLHHETHLVIDHDVMKSYIDALLPNTTEEQRRDPSISPFWADLRGKKLPPALFTCGSEDPLLDDSVMMGSKWAMWGNESIVKIYHGAPHGFIGFPPGTIKAVQDALNDTEAFVRAKRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1A0</accession>
    <name>M2T1A0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_33250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695492.1">
        <property type="nucleotide sequence ID" value="XM_007697302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1A0"/>
    <dbReference type="STRING" id="665912.M2T1A0"/>
    <dbReference type="GeneID" id="19137105"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33250"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010228_0_1_1"/>
    <dbReference type="OMA" id="HEIDGCA"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="157"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD68310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="694" mass="77002" checksum="E0FAAECFD50BB3EC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1S6</accession>
    <name>M2T1S6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_200756</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701378.1">
        <property type="nucleotide sequence ID" value="XM_007703188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1S6"/>
    <dbReference type="STRING" id="665912.M2T1S6"/>
    <dbReference type="MEROPS" id="M01.034"/>
    <dbReference type="GeneID" id="19134157"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_200756"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_1_1"/>
    <dbReference type="OMA" id="CTALQWM"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696189.1">
        <property type="nucleotide sequence ID" value="XM_007697999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2E2"/>
    <dbReference type="STRING" id="665912.M2T2E2"/>
    <dbReference type="GeneID" id="19131802"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157056"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_0_1_1"/>
    <dbReference type="OMA" id="FQYYPQY"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="109"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="347" mass="38160" checksum="84CAB0BDCEF20C56" modified="2013-05-01" version="1">MAAAPPASELKLDPKYDDYDYPTVSPTAQSGHPGHTTPEQDAALVELRTALEQAGHTKNLDTLTLLRFLRARKFDVELSKKMFIDCEKWRSEYAGVGVEELVRTFDYTERPQVFEYYPQYYHKTDKDGRPVYIEQLGKVDLTALNKITTEERMIQNLVCEYEKMADPRLPACSRKSGYLLETSCTIMDLKGVGIAKATSVYGYLGKVSTISQNYYPERLGKMYIINAPWGFSGVFSVVKKFLDPVTSAKIHVLGSGYQKELLAQVPAENLPKEFGGTCQCEKGCSLSDAGPWWDAQWAKEPKWAKKSDGDAINNTAIPPQTTEGTPGAAPAAPAGTEPAGAPAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3J5</accession>
    <name>M2T3J5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">COCSADRAFT_182008</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700818.1">
        <property type="nucleotide sequence ID" value="XM_007702628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3J5"/>
    <dbReference type="STRING" id="665912.M2T3J5"/>
    <dbReference type="GeneID" id="19133333"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182008"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="OMA" id="PVQKDCD"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
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    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="95"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="23"/>
            <end position="97"/>
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            <begin position="1"/>
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        <source>
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        <source>
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    <sequence length="1068" mass="117229" checksum="BE163DCCCE800588" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
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        <name evidence="3" type="ORF">COCSADRAFT_166070</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    </feature>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="201" mass="22488" checksum="C5E047FF55E057D4" modified="2013-05-01" version="1">MPQSPRILKIEDLPATSAKWISFQKISWQDQTGKDRVWEAAARKTRSKSGVDAVAIVTIIRHPSRPPSTIIILQYRPPVNAVCVELPAGLVDEKESPSEASVRELYEETGYQGKLKFISPTIVSDPGMSTANMQLAVVEVELAEGDEEPEQALDDGEFIERVVVPVDDLYERLIEYDKEGKTVDARLWHWAAGWHAAKSMM</sequence>
</entry>
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    <accession>M2T4B2</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007702277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4B2"/>
    <dbReference type="GeneID" id="19139027"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37613"/>
    <dbReference type="eggNOG" id="ENOG502SS2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063710_0_0_1"/>
    <dbReference type="OMA" id="GFTACAQ"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026388" evidence="1">
        <location>
            <begin position="18"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="332" mass="35162" checksum="B5371394F5F4B111" modified="2013-05-01" version="1">MARFLQILLAAATLVAGQSAICPNEVAIYNPQDRTQSFTNNWFLVPVPKEEVKKALQQAFPALFNLGGLNLLPVPASLNFPAGMHPVVASAGMTNDIRQDNFQIATGLMFAGSLIPYVGIGSSQTPLSVPLVNYIAGVDEVTQAYVAGIIPSVVATIAGILFRIGAFIPFSSPFQSYSDGSLGINSKWAQAPNPASGPGIYSEAIDLKFVNEPNQASPRYTLAQWKRIINQPWILANVASLLNPKCQRSTFYFTNATAVPTFRTGNVTLGPSASVDPLTAVLQRASPDGSGFYRGVYGFTACAQNVGYGAVVPQGEDCEVAAQIVASSPGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2T550</accession>
    <name>M2T550_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase</fullName>
            <ecNumber evidence="4">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_117097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="4"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699984.1">
        <property type="nucleotide sequence ID" value="XM_007701794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T550"/>
    <dbReference type="STRING" id="665912.M2T550"/>
    <dbReference type="GeneID" id="19130348"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_117097"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_6_0_1"/>
    <dbReference type="OMA" id="DVGCGWL"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026421" description="Amine oxidase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD64097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="537" mass="60225" checksum="AEB41E28C76C9929" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5K7</accession>
    <name>M2T5K7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_155870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694964.1">
        <property type="nucleotide sequence ID" value="XM_007696774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5K7"/>
    <dbReference type="STRING" id="665912.M2T5K7"/>
    <dbReference type="GeneID" id="19131721"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155870"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_5_0_1"/>
    <dbReference type="OMA" id="RAHMLYF"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="650"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="80864" checksum="9AAEF9BABCCB5590" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6N6</accession>
    <name>M2T6N6_COCSN</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD66041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699029.1">
        <property type="nucleotide sequence ID" value="XM_007700839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9Z1"/>
    <dbReference type="STRING" id="665912.M2T9Z1"/>
    <dbReference type="GeneID" id="19141110"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_86437"/>
    <dbReference type="eggNOG" id="ENOG502SAH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057752_7_0_1"/>
    <dbReference type="OMA" id="ANLTHEW"/>
    <dbReference type="OrthoDB" id="3688938at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="210" mass="23558" checksum="542780BC155BB1CE" modified="2013-05-01" version="1">MFNDTKYSDAMVVIQGKKLPVHKSVICTQSEYFEKAFQDAFVEGSSGVLTFDNGSGAAHWRVFEYLYTGDYSDDLSHDFEDDPALLKEARVYALANMFFLEDLKAFATAKLQQKLEELWTSESFPECIREVYATTPESDRAMRSAVVEVAKDHVRELGKMVLFKDLLREGGDFAVDYFESVVFPAPPAVLSTHLRAGGLFGGTCKNSSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9Z5</accession>
    <name>M2T9Z5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_309177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698805.1">
        <property type="nucleotide sequence ID" value="XM_007700615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9Z5"/>
    <dbReference type="STRING" id="665912.M2T9Z5"/>
    <dbReference type="GeneID" id="19136341"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_309177"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="262" mass="28885" checksum="0A3918D08975CCEF" modified="2013-05-01" version="1">MGKPPNLYAFQSAAELAPSLRAYVLDAQNAALDRHHVFRVAVSGGSLPKTLAQALLKETNGEGKIQFDKWEIFYADERAVPLDHEDSNHRLVKEELLDKIPQELGTPKVHPIDVKYLDDVQELADQYEKTLVSVFAARDSVKLPLFDLLLLGCGPDGHTCSLFPGSDLLRETEAWVLPISDSPKPPPKRITISLPVAQHGLKIAFVATGGGKKDIMRQIFDTDEGQQLPCGLVNHRGGERVSWFVDYPAIEGVSFPARRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2TD38</accession>
    <name>M2TD38_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_35169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697597.1">
        <property type="nucleotide sequence ID" value="XM_007699407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TD38"/>
    <dbReference type="STRING" id="665912.M2TD38"/>
    <dbReference type="GeneID" id="19138110"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35169"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_3_0_1"/>
    <dbReference type="OMA" id="GNCARCT"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF34">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G07820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="114"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="295" mass="32291" checksum="79C4BCAD3A29D2AF" modified="2013-05-01" version="1">MAVASYPQMTQFLQEISPSPPSATSNAHSNSSTDSTLTIHYLAHGATPNQSSLTIPLNPPTTLLQTLEISLHGSPATAYRMPDPYNTWFTSCFGFPVELVYLGSSRRSPRFSNLTSSSSSPTTSSSSASAPQIAQSLTFTDCAPYLITSSASLSSVSSRIASEMDITKFRPNILLSGAKEAWDEDYWSRIQIESEKAQTEVALLHNCVRCKSINIDYATGKPGTGVKGEVLKRLQGDRRVDQGARWSPVFGRYGFWVGGGKGREEKEEVVWRVGDKVRVTGVNRERTVWSWPNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2TD56</accession>
    <name>M2TD56_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_157588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696901.1">
        <property type="nucleotide sequence ID" value="XM_007698711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TD56"/>
    <dbReference type="STRING" id="665912.M2TD56"/>
    <dbReference type="GeneID" id="19131833"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157588"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_15_4_1"/>
    <dbReference type="OMA" id="MRYFSPY"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27624" checksum="4345C9557F3F0800" modified="2013-05-01" version="1">MSSPKLVVHHLQVGQGERIPWLLEELNIPYELKLYQRSPLLSPPELKAVYPLGSSPVFEDVTDPSNPIKIAESGAISEYIIQKYANGRLALEPQHKNFADYLYWFHFANGTLHPTLFRRTSARAMVGEQDPRYIGVADRAANALKHVNDRLLNNTWLAGDEFTAADIMNAWSFTTMRKFEPIDLSDYQGILAWLKRVGEREAYRRAMAKSDPDLNLEEGLSAKGPPLMEAWAKAMGMKPGRQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDI7</accession>
    <name>M2TDI7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_85501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698204.1">
        <property type="nucleotide sequence ID" value="XM_007700014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDI7"/>
    <dbReference type="STRING" id="665912.M2TDI7"/>
    <dbReference type="GeneID" id="19141065"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85501"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040321_0_1_1"/>
    <dbReference type="OMA" id="MNALQYW"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026660" description="peptidylprolyl isomerase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="41"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696604.1">
        <property type="nucleotide sequence ID" value="XM_007698414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEE5"/>
    <dbReference type="GeneID" id="19137623"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34382"/>
    <dbReference type="eggNOG" id="ENOG502REVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049215_0_0_1"/>
    <dbReference type="OMA" id="WVGRHEK"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33974" checksum="C20D9C2166C0EBA5" modified="2013-05-01" version="1">MKPLPQDQQALLDEVADLERRLQDAKARLNPAAVVATPPFSPLPNAGPSPPVPPFSPAEQDAALHALLLLADSALPLGSFAFSSGLESYLAHHKPATPSASQLPAFNTFLRLSLSTLASTSLPYVFAGYRDPQEIETLDNDFDASTPCTVARRASIAQGRALLAVWDRSFRAQYNSPERHMRDSSLNGIAEKNTAVETLASFSAALRTSEHMNAHLAPLWGLITSILHVPLQQAAYLFLFSHARTVVSAAVRASVMGPYQAQAVLASAELQERIRGLVDEGWDKTVEDAGQSVPVMDLWVGRHEKLYSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEQ7</accession>
    <name>M2TEQ7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_82794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697300.1">
        <property type="nucleotide sequence ID" value="XM_007699110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEQ7"/>
    <dbReference type="STRING" id="665912.M2TEQ7"/>
    <dbReference type="GeneID" id="19140917"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82794"/>
    <dbReference type="eggNOG" id="KOG0642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009046_0_0_1"/>
    <dbReference type="OMA" id="SKCSQEV"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="737"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="566"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="816" mass="87993" checksum="ECC2C01653B8ACA9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEW5</accession>
    <name>M2TEW5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_288083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696981.1">
        <property type="nucleotide sequence ID" value="XM_007698791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEW5"/>
    <dbReference type="GeneID" id="19135918"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_288083"/>
    <dbReference type="HOGENOM" id="CLU_2867519_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="64" mass="7477" checksum="5A4E3A6636B5EE8B" modified="2013-05-01" version="1">MKSMKMADEKVTLPLFQGSLLVWLGRLFVLAIMLIDPCFLLTHLRILYFLGVSESEIEREKVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2TG45</accession>
    <name>M2TG45_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_33168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695472.1">
        <property type="nucleotide sequence ID" value="XM_007697282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TG45"/>
    <dbReference type="GeneID" id="19137068"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33168"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OMA" id="DNPPSWG"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012565179" description="Peptidase S8/S53 domain-containing protein" evidence="8">
        <location>
            <begin position="16"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="148"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="40498" checksum="1D23C4EDB7557B36" modified="2013-05-01" version="1">MKLSLLLALLPVALALPAPVIIPRAGTPIPGRYIVKLKNQNLENLINTALKLLKKDPTHVYKFGGFGGFSADITDDIVELLRNLPGVDYIEQDAVVQANLGVEVELEKKAYTTQSSAPWGLARISSQSRGTTSYTYDTSGGEGTCSYIIDTGIQINHPEFEGRATWLANFADSSNTDGNGHGTHCAGTIGSKTYGVAKKTQLYAVKVLDASGSGTNSGVIAGINFVATDAKTRSCPNGAVANMSLGGSRSTAVNSAAANAVSAGVFFAVAAGNSAANAANFSPASEPTVYTVGATDSSDRLATFSNFGTSVDILAPGVSILSTWIGGRTNTISGTSMASPHVAGLAAYILTLEGKKTPAALSSRLTTLSLKSKITGLPSGTVNNLAFNGNPTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2TH14</accession>
    <name>M2TH14_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_167750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696099.1">
        <property type="nucleotide sequence ID" value="XM_007697909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TH14"/>
    <dbReference type="GeneID" id="19132533"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167750"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059421_0_0_1"/>
    <dbReference type="OMA" id="SCVLIFR"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="389" mass="44673" checksum="8B8CB7A1BEC84EFA" modified="2013-05-01" version="1">MLGRWILRPGSCLSLARRHPKARCRASSAHIPGHILRGDDLGPTRKDDYQTVRVRKDKQAKDLPLPPLLDPLVLKQRSRFEQRKERPNVANFTPFQKRLWENPFAHALASPVRQCRSTLISLPVAFLTSLHPRPHPTTQDPWLLPVSLTTDTKHLGPPYRFLGRHVVAAHLSKNKAWEKGLNARMREKFSAHNLKNMVWREDMADFILEMMRKRLADGLTWYFGFKGRLVPVPSPRSEDIEDVEDVSCVLIFRSLRTRANDIQVRSDENKTELEKWSSYFAKNFASKLDPHAAPGVTHTSPHWYSGPIVPRMQPRLHFPELEFHATAWRGKKVAVYSLLDLLGEEQAQVLVEGSKYANEKCVVLKRGRHSIPIQILLMQVQAYVARPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2THH4</accession>
    <name>M2THH4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF747 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_108322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="591" mass="66203" checksum="34B4FDB0A98BB805" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIZ6</accession>
    <name>M2TIZ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_167885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696215.1">
        <property type="nucleotide sequence ID" value="XM_007698025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIZ6"/>
    <dbReference type="STRING" id="665912.M2TIZ6"/>
    <dbReference type="GeneID" id="19132541"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167885"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011639_0_0_1"/>
    <dbReference type="OMA" id="DEFELWG"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="136"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="301"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="845"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="858"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="882" mass="99676" checksum="AAA3ED8DCDC27EF1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ14</accession>
    <name>M2TJ14_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_275658</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696230.1">
        <property type="nucleotide sequence ID" value="XM_007698040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ14"/>
    <dbReference type="STRING" id="665912.M2TJ14"/>
    <dbReference type="GeneID" id="19135702"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_275658"/>
    <dbReference type="eggNOG" id="KOG3262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080002_2_1_1"/>
    <dbReference type="OMA" id="PMKLLPM"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="95" mass="10635" checksum="120413939B0356FB" modified="2013-05-01" version="1">MGASFGPPDTVVEMGKFVHDCENEMFCESINTKIPYFNAPIYLENKTPIGKVDEIMGPLNQVYFTIKPQEGIQAKSFKAGDKFYIGGDKLLPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TK46</accession>
    <name>M2TK46_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_31843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694124.1">
        <property type="nucleotide sequence ID" value="XM_007695934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TK46"/>
    <dbReference type="STRING" id="665912.M2TK46"/>
    <dbReference type="GeneID" id="19136546"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31843"/>
    <dbReference type="eggNOG" id="ENOG502RG2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044083_3_1_1"/>
    <dbReference type="OMA" id="QVPMKAR"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="226" mass="24871" checksum="2B77FA2E06D36053" modified="2013-05-01" version="1">MISILGGPRHRTALKGIAVVGALCLLITLIVGLRHERPHADLRIPLRILPLGDSITWGWQPDNQQHGTDGYRAQLLHNLIHGWYQSVDFVGTQHSGFMFDNDNEGHVNSTISEIMGAMTTALQMQPNVVLVHVGTTDLDRSDSALWKDAPQQLGRLLDAVLEACPDAVVLVAKIIQALNQRTSDNIRAFNEAVPEVVEERAKKGFNIRVVDQSAVSVYELVDGLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKK3</accession>
    <name>M2TKK3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_212746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ND90Pr</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694941.1">
        <property type="nucleotide sequence ID" value="XM_007696751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKK3"/>
    <dbReference type="GeneID" id="19134434"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_212746"/>
    <dbReference type="eggNOG" id="ENOG502S9N5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065416_2_1_1"/>
    <dbReference type="OMA" id="HDNACGP"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="288" mass="31730" checksum="77421EAA9B590C42" modified="2013-05-01" version="1">MTSSKTSMDSLYSDFASKYEISTGGCTRQLATYLLSLLPALSSTSHIHDNACGPGILAQEVLFQNHSLTPSITCTDSSPQMITLAQHTIPAITPSNAANLSFHVLPGDALDLLPSESFTHSITNMGIFFFTDALKGAREIHRTLTPNGTAIVTTWKSAGYMPILHCAQKAVRPQDPLFEWPIAKEWYEADHLQEILRKVGFESVEMSEVTVHFAGKSLEETCGFLVDMWKQVGPKWTEEEYVEFGKQLVVEGRKEAITMNRPVNGKKDAEIVEVVGFPMVAHVAVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKN5</accession>
    <name>M2TKN5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_155457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694641.1">
        <property type="nucleotide sequence ID" value="XM_007696451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKN5"/>
    <dbReference type="STRING" id="665912.M2TKN5"/>
    <dbReference type="GeneID" id="19131699"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155457"/>
    <dbReference type="HOGENOM" id="CLU_1713088_0_0_1"/>
    <dbReference type="OMA" id="MIRVEHE"/>
    <dbReference type="OrthoDB" id="3787216at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="153" mass="17515" checksum="077A06C3AF91F01C" modified="2013-05-01" version="1">MGILDVSVSPIDGESPTEAMIRVEHEVDRQNKCIIENSTFQKWQQDLSTRLLWIKGDPGKGKTMLMCGIIDEVQKTTRHNNTVAYFFCQATDMRINNAVAVLRGLLYMLVIQNSLLTSHIRKRYDQVGKKLFEDANAWVALPQILWTWCATKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLV7</accession>
    <name>M2TLV7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_166645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694933.1">
        <property type="nucleotide sequence ID" value="XM_007696743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLV7"/>
    <dbReference type="GeneID" id="19132464"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_166645"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OMA" id="NANTVWH"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF134">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="5">
        <location>
            <begin position="423"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="504"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="62682" checksum="52B4940064B49768" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLY8</accession>
    <name>M2TLY8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_166673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694950.1">
        <property type="nucleotide sequence ID" value="XM_007696760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLY8"/>
    <dbReference type="STRING" id="665912.M2TLY8"/>
    <dbReference type="GeneID" id="19132466"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_166673"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027074_11_2_1"/>
    <dbReference type="OMA" id="CAYLMWK"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="231" mass="25961" checksum="324AABD3EF18C241" modified="2013-05-01" version="1">MSYLLHGSTSYTGMGWVDLVPRCGRIYIGGLYALYQTDLIEAAGITHVLSVIDYDALLQEKFRHLRHFHIRAEDHPNTNLLQFFEGGVNYIDEALASSPLTPSEAQATDAKMSPSKGGNIAPGGGVFVHCAMGKSRSATLVCAYLIWKYNISPEAALEQLCEGRPICDPNPGFKEQLEVWSTMCRAGSEEEKKGIYERWEKDRFTGEVWDWETRVKQQEREKVTSHQASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2QSN0</accession>
    <name>M2QSN0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_68679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445670">
        <property type="protein sequence ID" value="EMD58189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706110.1">
        <property type="nucleotide sequence ID" value="XM_007707920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QSN0"/>
    <dbReference type="GeneID" id="19140452"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_68679"/>
    <dbReference type="HOGENOM" id="CLU_178955_1_0_1"/>
    <dbReference type="OrthoDB" id="3690956at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="69" mass="7750" checksum="E752EA43145F044E" modified="2013-05-01" version="1" fragment="single">VATTKEGPVPQVAPTKDEPLLAIPAEYRTREFKELFEENEATDLAEHQDWDHEIILEEGAKLSPGGMYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2QXB9</accession>
    <name>M2QXB9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_40878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704509.1">
        <property type="nucleotide sequence ID" value="XM_007706319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QXB9"/>
    <dbReference type="STRING" id="665912.M2QXB9"/>
    <dbReference type="GeneID" id="19139856"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40878"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="WEVANVI"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="283" mass="29959" checksum="50DE8FBCCE948D7E" modified="2013-05-01" version="1">MSHARKNSLWTPPVVQTPKLLTGKSMMITGGVTGIGRAIVLGYLQHGANVAVNHLGDDKSSSQYQSLVDEASHILDVSKEDVEKRLVEVPGDVGNPETGKKMVAAVVERWGRLDVVISNAGICEFKEFLDISEDLWTSTLNTNLTGAFHTIQAGAKQLSIQSPPGGSIIGISSISALVGGAYQGHYTPTKAGVLSLIQSSACALGKHNIRCNALLPGTIKTQLNEKDLEDEAKRKYMEGRIPLGRTGVPSDLAGPAVFLGSDLSSYVNGAQLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZA9</accession>
    <name>M2QZA9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_163726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="413"/>
            <end position="561"/>
        </location>
    </feature>
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        <location>
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            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="763" mass="85108" checksum="3F733912F1140401" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Nuclear localization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_149124</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R0N7"/>
    <dbReference type="STRING" id="665912.M2R0N7"/>
    <dbReference type="GeneID" id="19131475"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_149124"/>
    <dbReference type="eggNOG" id="ENOG502QW07">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_022149_0_0_1"/>
    <dbReference type="OMA" id="SANWQFE"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
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        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD60874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54427" checksum="D075C9489A2986B1" modified="2013-05-01" version="1">MARGRPSRAAARRSTPVRSATPQQDSDEDMIDPPESRAETPKEEEEEEEAASAAQASDEEAAPSERSPSPAVIQPFPRKKRLGRPPKNRPPDWNAGEPDNSEGGTPVKRKRGRPSGGGRGRPPKGGQSHTTRVPIDKEGTMMDVVNDEVDLPEDEEGEKKVDKLGNLMGGRDYRVRIFTIRGRGDRQYMLSTEPARCCGFRDSYLFFTKHMKLHKIIIDDTEKRDLIDREIIPHSYKGRAIGVVTARSVFREFGARIIIGGKRIIDDYYVTAAKENGAVEGELADPNDRLPPPGEPYNKNQYVAWHGASSVYHTGVPSVPTANGKPAPGKRKVNITSANWQFEHGSAASRFNSSLSKLRKANLSGIYDPHTNLMCYPKVTQPTHARWEEVAPEDTDVPPLVRRKYLVVDTVFQQPPFAGLGIPGPDGDFIDVGTNGLPKLDAEDEKHMKPEELEAFSQIKREEQEWRSQWGGESTDGARVKPKIGFVGVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2R522</accession>
    <name>M2R522_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_38221</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R522"/>
    <dbReference type="STRING" id="665912.M2R522"/>
    <dbReference type="GeneID" id="19139201"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38221"/>
    <dbReference type="eggNOG" id="KOG2912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027534_0_1_1"/>
    <dbReference type="OMA" id="HQGRYDF"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48909" checksum="EA06D6C925BFE69C" modified="2013-05-01" version="1">MLLEQRPPYDTVDFKALAKSDNDFKQIWQRALGKLDFQDPHTVQALSKAILKSDFGLELDVPDDRLCPPIPNRWNYVAWIQGLVDSTSPDYSNKYDPNRHVQGLDIGTGASAIYTMLCLRSRPNWSMCATDIDKKSFDSAARNLALNHLMTRTKLLQTTALTPLIPLAALGLTHLDFTICNPPFFATPSEMRSSLAGEGKSSKPNAICTGSENEMVSPGGDVGFVTALVNESLVLREKVQWYSSLFGKMDSAKAIIRLLKQHGITNWAVGVIEAGASGTKRWIVAWSFGDLRPRNSHARIEKMANEYLPFPTCYPITLPPSIDPQQAKDAITTQMASLDLLSWTWDPSTCTGIGEAAQNVWSRSYRRIYEKRVKEESGVDEMQGTDEEGERMQVKLSFRIRVVDLAREVVVEWVKGRDQVLWESVCGLVHRHFKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2R5U7</accession>
    <name>M2R5U7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_172996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701886.1">
        <property type="nucleotide sequence ID" value="XM_007703696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R5U7"/>
    <dbReference type="STRING" id="665912.M2R5U7"/>
    <dbReference type="GeneID" id="19132820"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_172996"/>
    <dbReference type="eggNOG" id="ENOG502QRW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_1_0_1"/>
    <dbReference type="OMA" id="GETSPKW"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="309"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD62544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="506" mass="57139" checksum="0B6412109229754E" modified="2013-05-01" version="1">MASFTRIEESETPSISINPSHKVAKINDNLYGGFTEHMGRCIYGGIYDPGNPLSDERGFRKDVIEAFKELKVPVVRYPGGNFVATYHWLDGVGPKENRPKRPELAWIGIEPNTFGTDEFMQWCEEVGTEPYLCLNFGTGTLDEALGWLEYCNSDRDTYYANLRRKNGREKPYNVKYWALGNECWGPWQVEQMTKEDYAKKAYQWAKALKLLDPTITTILCGETGYSSWDYYVLNQCVKLDVHGLSGDMTKSLIDMHSIHIYTADKEHLPNATAPRAAERAIQMASSLIDLARIENNVPETVPRQTICFDEWNVWDPVRAPGEQGAEEKYTLSDALAVANFLNGFIRQAKDVGMATVAQSVNVISPLMTTKEGLVKQTTWWPLLLFSKYMRGHTIALNVRTPEYNGRTNPKWIRGTIETPYLDCSAVLSDDGFVNLAVTNIHETRDFEVEIPGLKADKVEVHTVTGENIGVVNTNGEQKVGIKESSWDGKGKFTFGKHSFTLLRWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBR7</accession>
    <name>M2RBR7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_117484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700123.1">
        <property type="nucleotide sequence ID" value="XM_007701933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBR7"/>
    <dbReference type="GeneID" id="19130362"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_117484"/>
    <dbReference type="eggNOG" id="ENOG502SKYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043632_0_0_1"/>
    <dbReference type="OMA" id="RHKMGEM"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD64289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="517" mass="58330" checksum="73D6BF257CE19298" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2RD31</accession>
    <name>M2RD31_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_88273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699304.1">
        <property type="nucleotide sequence ID" value="XM_007701114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RD31"/>
    <dbReference type="STRING" id="665912.M2RD31"/>
    <dbReference type="GeneID" id="19141227"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_88273"/>
    <dbReference type="eggNOG" id="KOG2081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005996_0_0_1"/>
    <dbReference type="OMA" id="LECITSW"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD64714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="952" mass="107452" checksum="E3E4C7676384BF2C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2RFB5</accession>
    <name>M2RFB5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Precorrin-2 dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_305745</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698597.1">
        <property type="nucleotide sequence ID" value="XM_007700407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RFB5"/>
    <dbReference type="STRING" id="665912.M2RFB5"/>
    <dbReference type="GeneID" id="19136271"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_305745"/>
    <dbReference type="eggNOG" id="KOG1527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_2_2_1"/>
    <dbReference type="OMA" id="TPCAIVE"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000504">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="492" mass="51689" checksum="0211EE8B1875A956" modified="2013-05-01" version="1">MSGSATLPNDPRISFQAPSLSQGSASHSSCEQHGSATTESNATPQPLTSTTTTKQSVPLGVFSTLLGSNSTSTLSAQPILSDEAVPAILIHAQPPDTQEGPSDLTASLSSVPSATTTLTNTLPPTQSAALRALNAPAFHSSPSKSKSAKSTSSRTTVTSQPVVVRTYSGSRHTSRAGSGFNTPRSFAMNGNNHTSALSAGLAGRSEQLPSADDFSFSAILRAVDPEIKDAIDAIAEICARSRMSLADEYDSHLPPQGEITGTGPGWAASTGALVGRGRLNRISQGWTAADNTLMAVPEASSSSERLAQEGKVESNKKRSQSAYGSLKSVISGGSGKRKAIDGDTFREQEASSSKQDEVQNLGPPWAVHTSTSSSHPAITLAAPTASKHLSLDTSSTMQDKIDFLMHTSDMRAQNEALQRPPSLQRRQTTRSLPSSRARAGTLGSLKAWLPWPRPSDLNHDAQQELARAEDQLRRMLMSPQNIGKGKATVSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRS8</accession>
    <name>M2RRS8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_32025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694176.1">
        <property type="nucleotide sequence ID" value="XM_007695986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RRS8"/>
    <dbReference type="STRING" id="665912.M2RRS8"/>
    <dbReference type="GeneID" id="19136607"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32025"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_2_1_1"/>
    <dbReference type="OMA" id="VRKKMWW"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000063">
        <property type="entry name" value="Synaptobrevin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD69279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="122" mass="13588" checksum="40E36C4E12D794A1" modified="2013-05-01" version="1">MSNREEPPYDPYIPNSGQQSGPPGGQQNGNHRTAALQAEIDSTVGIMRDNINKVSERGARLDSLQDKTDNLAVSAQGFRRGANRVRKQMWWKDMKMRMCLIVGIIILLIVIIVPSVVATQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSH5</accession>
    <name>M2RSH5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 10 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_186403</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 10 11"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694828.1">
        <property type="nucleotide sequence ID" value="XM_007696638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSH5"/>
    <dbReference type="GeneID" id="19133560"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_186403"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_0_1"/>
    <dbReference type="OMA" id="THFDAWA"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF3">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024904" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="31"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD69529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="221" mass="23769" checksum="B965C89534A7D045" modified="2013-05-01" version="1">MVSFTSIITAAVAATGALAAPATDVSLVARQNTPNGEGTHNGCFWSWWSDGGARATYTNGAGGSYSVSWGSGGNLVGGKGWNPGTARTITYSGSYNYNGNSYLAVYGWTRNPLVEYYVVENFGTYDPSSQSQNKGTVNSDGSSYKIAQSTRTNQPSIDGTRTFQQYWSVRQNKRSSGSVNMKTHFDAWASKGMRLGQHYYQIVATEGYFSTGNAQITVNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSS9</accession>
    <name>M2RSS9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_32298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694255.1">
        <property type="nucleotide sequence ID" value="XM_007696065.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2RSS9"/>
    <dbReference type="GeneID" id="19136724"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32298"/>
    <dbReference type="eggNOG" id="ENOG502R7J1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004333_0_0_1"/>
    <dbReference type="OMA" id="GDEICRG"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF21">
        <property type="entry name" value="GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="245"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1501"/>
            <end position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1540" mass="169921" checksum="16A065F9E3C2B6BB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2RTM8</accession>
    <name>M2RTM8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_107054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695124.1">
        <property type="nucleotide sequence ID" value="XM_007696934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RTM8"/>
    <dbReference type="GeneID" id="19130015"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_107054"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_35_0_1"/>
    <dbReference type="OMA" id="RISYRTW"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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    </protein>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <source>
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</entry>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="M2RU40"/>
    <dbReference type="GeneID" id="19133100"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_177709"/>
    <dbReference type="eggNOG" id="ENOG502SKMW">
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    <dbReference type="HOGENOM" id="CLU_066708_3_0_1"/>
    <dbReference type="OMA" id="HAGTWHF"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
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    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
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    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="45"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD70094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="200" mass="21585" checksum="8F37C36FD4967887" modified="2013-05-01" version="1">MMTTTTKTPWADTPFPLLKIPGSPGAPTCSNAGVLGVCIEMANVHNLLLRGLNSIYNQAPFVTLPADISDLMLYTTAWADTIHHHHSAEETLFFPRIEALAKAAGQDCNMAGNVAQHQGFEAGMAEMVRWAKRVGSGEVKYDAEVLKGLIDAFAPLLTQHLHEEIDTLVELEKCDEEGVRKAMKVTADEGARTADPCGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RVE9</accession>
    <name>M2RVE9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_41606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705262.1">
        <property type="nucleotide sequence ID" value="XM_007707072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RVE9"/>
    <dbReference type="GeneID" id="19140023"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41606"/>
    <dbReference type="HOGENOM" id="CLU_138726_0_0_1"/>
    <dbReference type="OMA" id="SIGQEWE"/>
    <dbReference type="OrthoDB" id="3913322at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024423" evidence="1">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="156" mass="16105" checksum="594FEAD802612D97" modified="2013-05-01" version="1">MRFSTLATALASISSASAAIYGITVPAVLSPNVTFPLTFNSNLDQSSSLDVAVAYGFSAPPAYRGALGFNYKTIYLAGEESGYKMGTNYTVDVLAPGAIAGYNGSVVVTASVYQIFGYSGVYRLNTFNVTVDVGDASPDDGVVFSGNGDTKATCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2S087</accession>
    <name>M2S087_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding module family 50 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_40283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703655.1">
        <property type="nucleotide sequence ID" value="XM_007705465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S087"/>
    <dbReference type="GeneID" id="19139688"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40283"/>
    <dbReference type="eggNOG" id="ENOG502S3JP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090055_0_0_1"/>
    <dbReference type="OMA" id="MSWFTEM"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD60663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="192" mass="21593" checksum="C0AF4FFD527B9CCC" modified="2013-05-01" version="1">MSRWTDMDSDAERLPSGFERLGYDADTQTYTFRDADGIMYESEPGNRYSKLHRVDSQSSSRSSRSASIHLLDNRNGRPSRTFDEMFNDHQDVISKDNREAVRMMLPFALIILVFLILVFKLLYAGDAESLTPAKESLDCHQGSHEVPIKQGDTCWAIAQTSHVTVEELLELQGNAHVDCDRLVPGKGICVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2S0L9</accession>
    <name>M2S0L9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_344834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703187.1">
        <property type="nucleotide sequence ID" value="XM_007704997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S0L9"/>
    <dbReference type="GeneID" id="19137678"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_344834"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
    <dbReference type="OMA" id="MDMMMLA"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="1">
        <location>
            <begin position="316"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="408" mass="45536" checksum="C71D506BCF64EB91" modified="2013-05-01" version="1">MHFLGFIPVHDMVTSQKKISQSDQACKAMSIRTYACTSVSFILERIVAAGKDYQREDIGLREDLIELGRDLLAALEIPSEFLRRSFWSEPALSAHCKLAVQLGLFQYLKDAGETGSSIDNLTQKTGVDTSLLQRIPHHLVSMKLLTFSNEKFLGTPLSDGLAAENFQKSIDFCYDVARPSFNCFPTFFKEMGYRIPNPGTNGPFQAAHGTELPFFPWLGATPPHLDEFDNFMSAYRAGKPNWYSVGFYPVAAYLIEGFDKDASETLLVDIGGGRGRDVQQFIAEHKAHPGKIVLQDREPIIASVSNQDKLPFELQTDEEGIKILENLRPALKSGYSQVLLVEIVVSEEEPTIAETAADMMMLAHLAVRERTRVEWEGVLEKAGYRLVGFYNFPGVAESVIEAELREAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2S2W0</accession>
    <name>M2S2W0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II beta 2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_39242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702603.1">
        <property type="nucleotide sequence ID" value="XM_007704413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S2W0"/>
    <dbReference type="GeneID" id="19139451"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39242"/>
    <dbReference type="eggNOG" id="ENOG502S2SB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035164_0_0_1"/>
    <dbReference type="OMA" id="KGRWYTT"/>
    <dbReference type="OrthoDB" id="5415241at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038816">
        <property type="entry name" value="Stationary_phase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342:SF1">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="48318" checksum="FBC3F09F644B21FC" modified="2013-05-01" version="1">MAPAVVHLHRLVVKNAKAFKAAWKHAAKLVQKQLPESARPADAVLQPILARNAPKHPLHRIAYLKQSKGRWYTTHSLIGAAVRRFTTSAARNSGVKYDKASFPKSRIGSIVMAQAGRAPFASTLRPNLTGGALGRTAGGYGWGSGRTGGARYFSHGPAAPAQVINNVSQAVRAFLVGGQKAQFDGVNPHNGEKRFKTVSALQDQVNRTLNKVPKTSPGSYISFNINPTVTALTPLKAVKGFATFAQEKETLNTEGLLDTLSVDFSRAVKELAAVLKDLQRLAALGDLPITYEDSALKVHFPGCDAQTVETICNDFGVTRGVVHEDESFNTFVGSDMALLFPFAPSQTPSECSFYQKPVADRQHIQPNIDWANMLSPSVTDSEGFSTPSEHSYDQVDDFMTEPNPWLSVSSPSGYESLHTSEAEEMDLEASMEFPERYTPLCEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2S5G1</accession>
    <name>M2S5G1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_220298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701777.1">
        <property type="nucleotide sequence ID" value="XM_007703587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S5G1"/>
    <dbReference type="STRING" id="665912.M2S5G1"/>
    <dbReference type="GeneID" id="19134569"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_220298"/>
    <dbReference type="eggNOG" id="ENOG502SGPV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013784_3_0_1"/>
    <dbReference type="OMA" id="SYLPIHW"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="92"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="473"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD62393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="637" mass="69500" checksum="0C9F2E88FBFB7299" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6P4</accession>
    <name>M2S6P4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_37718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007702779.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2S6P4"/>
    <dbReference type="GeneID" id="19139063"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37718"/>
    <dbReference type="eggNOG" id="ENOG502S5GS">
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    <dbReference type="HOGENOM" id="CLU_044090_0_0_1"/>
    <dbReference type="OMA" id="VMEAIVW"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
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        <property type="entry name" value="NUFIP1-like"/>
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        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCCH zinc finger"/>
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    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
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            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
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            <begin position="274"/>
            <end position="293"/>
        </location>
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        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
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            <end position="410"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD62818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="484" mass="53218" checksum="0155900F8656E5D8" modified="2013-05-01" version="1">MTFRFPPPPPPPPKATSNEQPYPSQREGHNRGGSERGRGRGGNQNRGGGSHNASGNSRGGHGQNHGRGDARGRSQRGGYQNNRGVGYHKNDTRDGHGNHHGNAPQNATSPEAHANSQPSPSAYSQPGLQYSPPKHAGQKRKLTDRNGNAQSQRNPQQHSSKPPRAKAAVPPQVPSFGFSLPLPSIPKPDNKKRKVTLGLSQKVEQDESSGEEDVDEEAAFSAKLKGGGFAFEHEGETITIQTGAEVAAWIKDRRKNFPTQQRIIEKQEAAAQKRSAELEFLRRMKGKPPKENEQATYIQKQPNKDRDEAKNDGEKQEAEKRRREELATLRKKLHESMVKKQSTPATVDLGLGYDSETESDEESSVLSESSVVSGSEESESDSDSESDDQAPETASSKTAPPPIKVPPPPRANSRAETKSNKMCTNWKRNGRCPYLSKCKYQHPPKEENIKLQGLYERMVEQELVKADQLALDAIKYLGQNGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2S806</accession>
    <name>M2S806_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_103362</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007707508.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2S806"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_103362"/>
    <dbReference type="eggNOG" id="KOG2806">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_2_4_1"/>
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    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="13">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
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            <end position="465"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="90"/>
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD58610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="484" mass="53696" checksum="CE7A0024D573ACCF" modified="2013-05-01" version="1">MLLRAKEEPDYTCTATKRCNLGCCGPLDDTGVGACGFGPTFCGDKCTSDCDRKSECDGGNWGPKYANLTTCPLNVCCSKHGFCGTTVDFCGPDPVPHPQCDLSKRTADSRTIGYYEGWNYQRPCGNMEPEEIPLGHWSHIMFSFALINPKTFHLEDMDAGTGSRVGRVAALKNRQPDLKVWIAVGGWAMNDPGPYRTAFSDMAGSEANQDKFFDSLLTFMRKYDLDGVDLDWEYPVAEDRGGIPADFDNYVNFLRRLRERLNSSGREYGVSVTLPASYWYLRGFNLQEMEPYISWFNVMTYDIHGVWDANIDSLGPYAHAHTNLTEIKMGLELLWRNKINPERVTLGLGFYGRSFTMKDPGCMKAGCEFTEGANGGACTGTPGVLSAAEINEIIQKGATTTYDEEAAVMIVTWDSNQWVSFDDTKTLKTKIDFAHQHCLGGTMVWAIDLDDGTLTKALGANIKRPVLPTYPLQQYSECGAKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2S810</accession>
    <name>M2S810_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_143386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD63418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007702349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S810"/>
    <dbReference type="GeneID" id="19131284"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_143386"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_7_1"/>
    <dbReference type="OMA" id="IWTVMIT"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="80"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="519" mass="57534" checksum="599088FB293EAD07" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8D2</accession>
    <name>M2S8D2_COCSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700399.1">
        <property type="nucleotide sequence ID" value="XM_007702209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8D2"/>
    <dbReference type="GeneID" id="19138959"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37358"/>
    <dbReference type="HOGENOM" id="CLU_2704643_0_0_1"/>
    <dbReference type="OrthoDB" id="3735213at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025358" evidence="2">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="73" mass="7660" checksum="C16182E6128E23D7" modified="2013-05-01" version="1">MKYTTPALPLLTVLTTALALALASAPTDPQRILPPNWSFTISSLLGPGCPDTGKNTSLIRTTRPTHGTNTIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2S9R2</accession>
    <name>M2S9R2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_160300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699955.1">
        <property type="nucleotide sequence ID" value="XM_007701765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S9R2"/>
    <dbReference type="GeneID" id="19132029"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_160300"/>
    <dbReference type="HOGENOM" id="CLU_1077719_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="258" mass="28961" checksum="D835B44BF6ECE5F8" modified="2013-05-01" version="1">MEHFTTATEHSNTTTEQLTLTMKQPTFSTPPAFPTSTTIDISSSLNHLSLLPQPPLPPPQPRLYTPTTLLSIPLPTVLALLDDITCIEVIDKIAFTNHIDPSSDPNDLISNPNMLPASAYHFFHAKLSRYLVHAAPTLTITLAQLREELDAYLTTMVWLHAVLYCGESVREKIMEAVASECVEVIEEDEGADMAVVKKVVKVWKEWMQKFVGGLVVENESERRDTQDESVRREAQDERVAWGMLVLVLFPSLVSYLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAU5</accession>
    <name>M2SAU5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_357440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700238.1">
        <property type="nucleotide sequence ID" value="XM_007702048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SAU5"/>
    <dbReference type="GeneID" id="19138501"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357440"/>
    <dbReference type="eggNOG" id="ENOG502SXED">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567587_0_0_1"/>
    <dbReference type="OMA" id="HTAKCTE"/>
    <dbReference type="OrthoDB" id="4755622at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="477" mass="52315" checksum="5B49C4089F015E05" modified="2013-05-01" version="1">MYPLTTPDSSRSTGNQVLTLTPENSCIHRGPSHANTPPHINTSHHFQSPSPPHTPHTPASTAPNSCTVDEPLYTRVAVHTAKCTECDKRNMDTMRRCPGCTFQVCQPCYEKRQRQGKGLVHGNMPSPEETGVATPSGTGARASRKKPVGSAVKASSSQKDVDEEESKECEESVQKAGKHTPSVPKSKATKRSRGRSCIEDSEAEESSEGELDPDHASPTPSKRHQTLSFAESALATATRAPPTTRAALRSNPSIAYLAPSTPQSETARPRVLVAHSREDYPYNDLLYQNCVLGYDEPLLARREPVTYNPTGRIPAIIQRSGHRRPTADEIYQNIQKKVRERLEKMHAEKSAPGPETPSVPAPNVSTPDAKTATTVRDFVEKEAMRHQDANILDEDDSKALFRTMQGAALAWGKKTFKKQEPAMQRLLLPGLNLQLDRIPDKYTTELRVLMDGVAEHTLHELDEAATLSTTSPPHPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB17</accession>
    <name>M2SB17_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_40850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704504.1">
        <property type="nucleotide sequence ID" value="XM_007706314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SB17"/>
    <dbReference type="GeneID" id="19139851"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40850"/>
    <dbReference type="eggNOG" id="ENOG502S62R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127770_1_0_1"/>
    <dbReference type="OMA" id="RNGCCDT"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="169" mass="18500" checksum="E9E132EB83018955" modified="2013-05-01" version="1">MRLLRILLSNLVRSPSKREYAHVHDVQIKWDGVLSVKEGGKGSSSSSANMALNVFKQPLALHSTQPLTGFTRTGYCEVPPSDAGNHAIAGIVSKEFLDFSAARGNDLRQVGLTDGCKWCLCVSRWKEAFDARTGLDDKKVPKVVLKATNEKALRGLAMEDLKKFAVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCV7</accession>
    <name>M2SCV7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division control protein 24 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_356431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699587.1">
        <property type="nucleotide sequence ID" value="XM_007701397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCV7"/>
    <dbReference type="GeneID" id="19138430"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_356431"/>
    <dbReference type="eggNOG" id="ENOG502S2YX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039318_0_0_1"/>
    <dbReference type="OMA" id="EHVNPPF"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="53164" checksum="A152F82780842C3B" modified="2013-05-01" version="1">MPSLSSIQFYFSSSPSKKSDGFIAGEMQSALAPAGVDTASTWTPTLDYGEADIGSLEPGPCNFALMGRIVNFSDQVRPSKSHKAAQGCIKVMVADNTGVLTVRLWYAETRYKLKLGQLVGIWTVHISNSSEFNALAPSTAPLFTSMFPEGERNCHFAVYEGSDDGTRFKRPYGVKESRALAGLMTLKSFMDGGYDVDEPKLLVCVRSIGARKKYMNRNGTTSELISLGIFDDTADGLLTLYSSMCDSASLFTPFNAILLISNPSWRIDRMAKLTITSGSRVDIDPDMGDARRLRAMAQYLTKREHVNPPFTIAPTAIEDFENATIKALYTLAEIDSVARSLSNSGKKERIVGYLSVLITGLNIVTPFKRNMLMSNECCGIPLFANSINVKCKHCENVVTLRINPRILGPILDETGQIGSGKLILSDDAWCQLLGRTPHQLVETDLDVLLYLEQRLLFLRLTMGFVLDLEDEIARLAIWCVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SEQ7</accession>
    <name>M2SEQ7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_355105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698828.1">
        <property type="nucleotide sequence ID" value="XM_007700638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SEQ7"/>
    <dbReference type="GeneID" id="19138337"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355105"/>
    <dbReference type="HOGENOM" id="CLU_1906562_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="133" mass="14413" checksum="8471D95D2CD1F257" modified="2013-05-01" version="1">MAAHFSIHSDMRDIIIPGKNHMFNRNVGGDGCNNSTANPNFTSQNHNEGAHQDNNFSLKGFLKGHIEIVAIVALTFLGFLAITLFVLYRHAIFGTSNDSKSVITSSPTPKSISSQASRTIPPLPRLSQSPLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFL1</accession>
    <name>M2SFL1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_124799</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703519.1">
        <property type="nucleotide sequence ID" value="XM_007705329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFL1"/>
    <dbReference type="STRING" id="665912.M2SFL1"/>
    <dbReference type="GeneID" id="19130605"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_124799"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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            <dbReference type="PubMed" id="23236275"/>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <dbReference type="GeneID" id="19137326"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33821"/>
    <dbReference type="eggNOG" id="ENOG502RPUU">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1713094_0_0_1"/>
    <dbReference type="OMA" id="ICWAWAG"/>
    <dbReference type="OrthoDB" id="3726364at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="153" mass="16782" checksum="73660EE682028382" modified="2013-05-01" version="1">MYAPMLCLAKGYIDLHSAPSTPTMPPLSFKRLYSYFLTAITMAMGTALLYSGVVGTFIDTLGWAKGFGMPTATEETAVLFASATGRNLGAGFFVWTQILRGDKRMLGMFMICWAWAGVADCMILWRHPDGQNVTKHMVNTVLAPTFGILLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIS6</accession>
    <name>M2SIS6_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">Malate/L-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_172762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701697.1">
        <property type="nucleotide sequence ID" value="XM_007703507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SIS6"/>
    <dbReference type="STRING" id="665912.M2SIS6"/>
    <dbReference type="GeneID" id="19132806"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_172762"/>
    <dbReference type="eggNOG" id="ENOG502S0M6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040452_2_0_1"/>
    <dbReference type="OMA" id="TNTEPAM"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="37886" checksum="4A649B2D336A5F76" modified="2013-05-01" version="1">MAQPTSDTKIFVAADEAERFVREVLMGNGVPKNNAEIVARCLIAADLRGVDTHGMNRIPSYLERVRQGVLDGTATPEVNQVTPAVAQVDGRNGWGFVAADVGMAAAIDSARVYGIGMASVKHSNHFGMSAWVVQKALDADMMSLVFTNSSPALPAWGGKSKLLGVSPIACGAPGNETPFILDMAPSIAARGKIYKAKRRGEPIPSDWALDKDGNATTDPAAALDGGVMLPMGGPKGSGLAIMMDVFSGVLSGSAFAGNVTGPYDPSKPSDVGHFLVAIKPDLFMSLQEFRDRMQYLYDKVVGADKAAGVERIYFPGELEQLQQKERETTGIPLVQAEIDALNGEASRVGVRPLQVKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJ22</accession>
    <name>M2SJ22_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701590.1">
        <property type="nucleotide sequence ID" value="XM_007703400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJ22"/>
    <dbReference type="GeneID" id="19139224"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38324"/>
    <dbReference type="HOGENOM" id="CLU_1895822_0_0_1"/>
    <dbReference type="OMA" id="TMAWNDA"/>
    <dbReference type="OrthoDB" id="10502550at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025478" description="REJ domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="14154" checksum="AC75566C55DA4C04" modified="2013-05-01" version="1">MLASSFTVSAIALFASLALAQSTASSTSSSAATTSMSMSMSSMSSMSSMSSMSSMSMSMVPMPTPSRADVTMAWNDAPASTSGAAMSGSMGSGMMTMSDGMVMPMSTGSAMGLMNMGNMTGSAGRLDVGTGVAFLGAMLAAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJZ1</accession>
    <name>M2SJZ1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_146568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701951.1">
        <property type="nucleotide sequence ID" value="XM_007703761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJZ1"/>
    <dbReference type="GeneID" id="19131384"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_146568"/>
    <dbReference type="eggNOG" id="ENOG502SICY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_1_1"/>
    <dbReference type="OMA" id="FNFIRRC"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="205"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="661" mass="73529" checksum="89299522FF993737" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SK33</accession>
    <name>M2SK33_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_352521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697171.1">
        <property type="nucleotide sequence ID" value="XM_007698981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SK33"/>
    <dbReference type="STRING" id="665912.M2SK33"/>
    <dbReference type="GeneID" id="19138160"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352521"/>
    <dbReference type="HOGENOM" id="CLU_532276_0_0_1"/>
    <dbReference type="OrthoDB" id="3677657at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="497" mass="55192" checksum="C2EA234D0E788102" modified="2013-05-01" version="1">MAEPADTECLSTKALRQIHSLMGEDALFLEHLPIDKIRGAEFEDKKQKRLTSLPQRILFGQITEGEKKGLEVWILPIKTRDENQWPGHRFNLFDRHGNLHSGITIEEAIRLTNAANAFKWLKKYGTMDSTLLRAVIRYYFMVKKVKPPSPWPVDKRFTAELLAACKVAAGISAKEARAKQKTQEREAGTALAYKRRPSPAPKQAARTMTSVDGLRAETTATSANGQKANTIKTPTSMPTGPKLNPTLPVSKAQSAPRYPVLQPSSTQPFPPSSPEDETSLFIPERRRHAATSEAFQTPTPVPHTSSAFIGQPRIEPIDEFKRAFQRKMLPKPAPMLAPTLTPIPTPSISTPSSHTMSIQQEINKPDSEKPDAPVVPAALAPATPAPVPPIATTSTILINPNIPLPLPFQPPTTPPTTKSSSSFIPAYRETLTKHSQLTALLRTTRSSLHTTRSQVQELEAKEKMLKEEIKRVEVEKKRLHDSLTPEKREVFLFGREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKF1</accession>
    <name>M2SKF1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_182139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701139.1">
        <property type="nucleotide sequence ID" value="XM_007702949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKF1"/>
    <dbReference type="STRING" id="665912.M2SKF1"/>
    <dbReference type="GeneID" id="19133344"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182139"/>
    <dbReference type="eggNOG" id="ENOG502R1BY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013691_3_0_1"/>
    <dbReference type="OMA" id="HMWPLEY"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD62795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="571" mass="64067" checksum="8E6491BDA3D703CF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SL26</accession>
    <name>M2SL26_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_352942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697423.1">
        <property type="nucleotide sequence ID" value="XM_007699233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SL26"/>
    <dbReference type="GeneID" id="19138196"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352942"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831568_0_0_1"/>
    <dbReference type="OrthoDB" id="3945980at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD67878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="334" mass="36798" checksum="8D9AD7EF4ED62DB4" modified="2013-05-01" version="1">MLPAYPGRILVEETRQTVSAKRRLQNRVAQRKYRERKAHKRKAPGGIILDLPAAPYSEIIPTQHSPIQQGHQEFDYWLDDLLVAERNPLIAAPLSKASSANTDSIEGHPITQSNSSDWYNPTGTGSDMLYMYAHSGFLPSPIPHPNNQAFGGLVGMHHTTSWSQEKQSHGQEQHPTYLTPPPSDAGRASSPRMTVEPSTTAANSSKQHEQGLRPQFAHATTPLQHLHGTISCERAIVEDTDIESPDPLLHVAIRSRSRDVIRVLFRQGAVIVDERDGKGRTALHIAAELGDEALVGLLLGQGADAQLQDHSGRLAVYFAVEKGYHEIVELLLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SL82</accession>
    <name>M2SL82_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_133038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695686.1">
        <property type="nucleotide sequence ID" value="XM_007697496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SL82"/>
    <dbReference type="GeneID" id="19130882"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_133038"/>
    <dbReference type="eggNOG" id="ENOG502QTYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_4_1_1"/>
    <dbReference type="OMA" id="TEDIPWV"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="329" mass="36982" checksum="E95C1B84DC5FCE55" modified="2013-05-01" version="1">MADKDPIVTHIFTADPSAHVFNNKLYVYPSHDRESNIPNNDNGDQYDMNDYHVLSMDSVGGPVTDHGVALRQEDIPWVSKQLWAPDAATKNGKYYLFFPARDKEGIFRVGVAEGDTPEGPFKPEPEPIKGSFSIDPAVFVDDDGAAYLYFGGIWGGQLQCWQTGKFERSAYETMEAQSGPALCAKVGKLTEDMKSFAEDVTDVVILDEEGKQLQSQDHDRRFFEAAWLHKYNGKYYFSYSTGDTHYLCYAIGDSPLGPFTYGGRILEPVIGWTTHHSIAEFKGKWYLFYHDSSLSKGVNHLRCVKIREIVYDEAGKIKLAESQPKVEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMF2</accession>
    <name>M2SMF2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007702185.1"/>
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        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
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        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
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        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="401" mass="43057" checksum="B7AAF681A15E0B98" modified="2013-05-01" version="1">MPSTRSLVAVGATIGQALANAVPKYAQIVDQKSFNVLPVVPPAVEFNATNLFIWPGATAESLLAKPFHIYDPEFYDVIGNDPSLTTIATSPSDPLFHEAVTWYPPTNEVFFVQNAGPPAAGTGLNKSAIIQKVAIADAERVRKGTLKSAPISIVNTSNPQIINPNGATMYKGKLIFAGEGQGDRVPSALYVMDPTPPYKTTTLLNNFFGRQFNSLNDLVVNPMNGDLYFTDTIYGYVQAFRPYPGIQQQVYRYNFNTGAITVVADGIEHPNGIAFSPDGKKAYVTDTGIANANFGLNLTAPASVYSFDVTKDGTFNNRQTFAFTPAFIPDGIKNDSKGRVYVGCGDGVWVYNAAAKLIGKIYTGTTAANFQFAGNGRMIITGQTKLFYATLSSSTTGTAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2SML6</accession>
    <name>M2SML6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_103927</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705849.1">
        <property type="nucleotide sequence ID" value="XM_007707659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SML6"/>
    <dbReference type="STRING" id="665912.M2SML6"/>
    <dbReference type="GeneID" id="19129874"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103927"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_0_1"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="114"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="256"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD58386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="347" mass="38584" checksum="F5C6387FA311B181" modified="2013-05-01" version="1">MNNKEKKKTDKKSTEYVIKSGLAGGFAGCAAKTVVGPLDRVKILFQTRNPQFAKYTGSWAGFPEAIRDIYATAGVRGLFKGHSATLLRIFPYAGVKFLAYEQIRARVIKNKAQETPVRRFVSGSLAGMMSVFLTYPLEVIRVRLAFETNENARSSLATIVRKIYSERAPRVHQPENPITATATHLVDTVTPRSGLPNFFRGFTPTLLGMIPYAGASFLAHDLMSDLMRVPLLAPYTTLPNTSREETSTSTHKPAQLRYWAELTTGGIAGFVSQTVSYPLEVIRRRMQVGGVVGDGHRLSMPEVTRRIYLERGYKGFFVGLTIGYVKVVPMVAVSFYAYERGKYYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMN1</accession>
    <name>M2SMN1_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_181802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696288.1">
        <property type="nucleotide sequence ID" value="XM_007698098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNK5"/>
    <dbReference type="GeneID" id="19133990"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_196644"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019691_1_0_1"/>
    <dbReference type="OMA" id="TCVRFEY"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="576" mass="64133" checksum="5AF999C44F81857C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP11</accession>
    <name>M2SP11_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="12" type="ORF">COCSADRAFT_81351</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696407.1">
        <property type="nucleotide sequence ID" value="XM_007698217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP11"/>
    <dbReference type="STRING" id="665912.M2SP11"/>
    <dbReference type="GeneID" id="19140827"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_81351"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_2_0_1"/>
    <dbReference type="OMA" id="AGKKWFP"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="118"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="320" mass="35918" checksum="8A45AF4ABAE44874" modified="2013-05-01" version="1">MSLKRKAAAAATDASKKTKQNGSITAFFGPPKTDPNAPPKQTAAAAKFDKDAWVAKLTDEQKDLLQLELETMHESWLPHLKDVLVTPQFLQLKRFLKQELASGKTVYPPMKDVYSWSRHTPLNTVKVVITGQDPYHGPNQAHGLCFSIRPPNPAPPSLQNIYKALKKEYPDYQPPPNKGGLLIPWAERGVLLINTCLTVRRGEANSHSGKGWELLMQKVIDTVAKVRTNGVVFLAWGTPAQQRAKGIPVDKHLVLKSVHPSPLSAARGFFDCGHFTKCNEWLVQRYGKDGGIDWDLNVDKQKEKEKEKEKEKEEEKEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ43</accession>
    <name>M2SQ43_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_41117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704856.1">
        <property type="nucleotide sequence ID" value="XM_007706666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ43"/>
    <dbReference type="STRING" id="665912.M2SQ43"/>
    <dbReference type="GeneID" id="19139914"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41117"/>
    <dbReference type="eggNOG" id="KOG0140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_4_1"/>
    <dbReference type="OMA" id="CNFWANR"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000044">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000037">
        <property type="entry name" value="Similar to acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF34">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="64"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="157"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="268"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD59241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49694" checksum="C760535563AEEEF7" modified="2013-05-01" version="1">MNFSIPDDLKQYLADLDNFIEEKILPLQHKGDNSRFFDHRREHARTDWDNGGLPRKEWEDLLAESRRLADEAGFYRLSLPKQYGGRSNADGRGSNLWMAVIREHLAAKGLGLFNDLQNEHSVVGNFPDVVMLMNFGSEQQKSEFIPLRLEGKFRMTFGLTEPDHGSDATHMATKGRPETRNGIKGWLLNGYKRWQTGMHNATHCSIFARTSGKDGEVKGISCFIVPVETPGLKAESYEWTLNMPTDHATVSIKDVWAPETAALGPIHNGLGVAQAFVHENRIRQAASSLGAAVYCVQQSVEYANERAPFGTPLSHNQGIQFPLVELATQCEMLRQLIRKTALEMDSMPHHEIEKKIGDKVSMCNYYANRLCTEAADRAIQVHGGNGYSRHFPFEHIWRHHRRYRITEGSEEIQMRKVAAYLFGFGGRKSLVDATKPGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQC0</accession>
    <name>M2SQC0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_41188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704875.1">
        <property type="nucleotide sequence ID" value="XM_007706685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQC0"/>
    <dbReference type="STRING" id="665912.M2SQC0"/>
    <dbReference type="GeneID" id="19139933"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41188"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_6_0_1"/>
    <dbReference type="OMA" id="GCLRFFI"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="40"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD59321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="342" mass="37588" checksum="13B45120024384EC" modified="2013-05-01" version="1">MSWLKRQAGPLIVLGSSALGGAAYRLAKPADASDATLNPHTFTPYTLVSKEPVSSTSAIFTLRNSNGVSDTESIKEVSKRSVWSVQIKQPQLQIARAYTPLPRTTDSTKTGDDDLGGMRLLIRQETGGEVSTYLHRLPEQSTIELRGPNTELKLPRDIIEVIFLAGGTGIAPAMQVAQALGRRTGSKMHILWANRKREECVGGVSNDSGQDQYGQDRIGWWKSLFGSPVQEPLVEPPSATEKGAIVTELDTLKKRSEAATKGLTVNYYVDEEKTFIQPGEVEQKIRRRREEAGSRLIIVSGPDGFIEYWAGRKLWANGTEIQGPLGGQLSRMDLGEWRVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQH5</accession>
    <name>M2SQH5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_90070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700288.1">
        <property type="nucleotide sequence ID" value="XM_007702098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQH5"/>
    <dbReference type="STRING" id="665912.M2SQH5"/>
    <dbReference type="GeneID" id="19141332"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90070"/>
    <dbReference type="eggNOG" id="KOG3985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_1_1"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="45"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="258"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD64535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="344" mass="37882" checksum="2B9B818283D114AA" modified="2013-05-01" version="1">MLSRVSLAPSAFKLHNITRIWTRNISIPYRRMAGVPNTYDAPVHIAVIGGTGISSLPGFTLAATLDINTPWGKPSSPISILQHPSPTTGKPIPVAFLSRHGLHHELAPHEVKNQANIAALRHIGVRTIIAFSAVGSLQEHVRPRDFLVPDQIIDRTKGIRPFTFFEGGMVGHVGFGDPFDKRLAAIVRQCGHALEGEGVTLHDNGTLICMEGPQFSTRAESNLYRSWGGSVINMSALPEAKLAREAEIGYQMICMATDYDCWRGDGEEDVNVEMVMAHMKANAENARRFVGAVLNELSKEEHVDQVLAKHLDGQMRFAGAMTKKEGRGQEAEKKLQWLFPGYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR57</accession>
    <name>M2SR57_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxidase</fullName>
            <ecNumber evidence="13">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_152826</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10 13">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="10">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007706834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR57"/>
    <dbReference type="GeneID" id="19131600"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_152826"/>
    <dbReference type="eggNOG" id="ENOG502QT8W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041038_0_1_1"/>
    <dbReference type="OMA" id="MIDCTSA"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haem_peroxidase"/>
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        <property type="entry name" value="Haem_peroxidase_sf"/>
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        <property type="entry name" value="Ligninase"/>
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        <property type="entry name" value="Peroxidases_AS"/>
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    </dbReference>
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        <property type="entry name" value="PEROXIDASE 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
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        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006993133" description="Peroxidase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="91"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="66"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="87"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD59262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="329" mass="35339" checksum="9A14998E3E369628" modified="2013-05-01" version="1">MYIRNILVSGLAAASTVQAYNNDTFGEDEKWIVADPAPVQKRQFINVFGLLSSIFGGGNKQDTSECPAIWTQISATLTQQFSANGECTDAARAAIRAAFHDCFPGACDGSLILANECAQAPSRGLQRFCSNLAGVASQTNVGVGDLIQFAAAHAVKTCPEGPVVPIRIGRQDSSRENDWRILPRGDARGNDVVRLFSSKGFSPVDLAALLGAHSTAKQQFVDPSQAGAALDSTPGVWDIKYYTETLRGNAPFILPADRNIARNPATALAFARFGVSKKAWDDAFVVAMVKMGMMGVTNRNMIDCTSALPKSSAAKREVKERRVSGRFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRB2</accession>
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        </recommendedName>
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    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_152007</name>
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    <organism evidence="5 6">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007706444.1"/>
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    <dbReference type="STRING" id="665912.M2SRB2"/>
    <dbReference type="GeneID" id="19131576"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_152007"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014024_0_0_1"/>
    <dbReference type="OMA" id="HMSEVLC"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
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    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
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    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="502"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="696"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="35"/>
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            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502S38Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="276" mass="31321" checksum="B81E863A37C84EEB" modified="2013-05-01" version="1">MAKTLSPITPVGCSFAGEAKSSNLKSATIRANEVPASIKIMKQKPTTPALPPLTHDVRVVTLAEYKQAAHCLAEAFNQDEVVRYFVDVPDLAHWTEERKFALHVEILEYITYAHILKGMVTTVGDFEAVALWMPPGQNIDDYPTVFRSGMWRLNFRLSAEGRRRFFGEFIPLLHDTMHTTLGDRELEAWYLVYIGTRPSGRGKGHARKLIEHVTKLADREGRPCYLESSNEANPAIYRKFGFQVTRRVNLQRGGKNIPMDIMVREPQMTEEKKSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS63</accession>
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            <fullName evidence="5">WD40 repeat-like protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_193424</name>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704208.1">
        <property type="nucleotide sequence ID" value="XM_007706018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS63"/>
    <dbReference type="STRING" id="665912.M2SS63"/>
    <dbReference type="GeneID" id="19133851"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193424"/>
    <dbReference type="eggNOG" id="ENOG502SVIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029545_1_0_1"/>
    <dbReference type="OMA" id="SCWNGGI"/>
    <dbReference type="OrthoDB" id="128867at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="54951" checksum="3CF5AECDDE9A8D23" modified="2013-05-01" version="1">MNGQPIPGFYWDLEKKKYFKIQSQNAARGLDLRYSAENIRKEERKEKIRKAATARSNKIRKERVVRRNPNSIIQTNIERELGSKRRSYYFNSLWTDVCAFGINTRPKQVISRRPCHASIRVFDRDPISRTIYAVQGSNSVNMQRIRTKDDPPAMGIDPSDYYDPPLANPYAFHPWDEVTRTTSTASSLTYLPATGALAVTTYGSDRPPEVWLSDPERDQPYVGQKFTPRDCTAIWAASARPTSFTTPPNITPTIAASQTEHLAVAASSSLLLFTRSQFGSWDSTLALKPLSSDILALDWLSYTTLALGSRDGSIRLYDTRSGGSSHILSHPYPISKLKRADDASRLVCSGLEDSLCLYDLRSPRQLPKSSNYHYQNFPKRRKYTHGNRKAVSTPLLNFEHANSEELDLDIAVHPRLGLLAAAQDLATGTAIRVSNLYTGKMVREIKWEGKGKGGWESIRSLKFMEGEGEEGGGVKLWSCWNGGIGEFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS86</accession>
    <name>M2SS86_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_167009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695216.1">
        <property type="nucleotide sequence ID" value="XM_007697026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS86"/>
    <dbReference type="STRING" id="665912.M2SS86"/>
    <dbReference type="GeneID" id="19132488"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167009"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_0_1_1"/>
    <dbReference type="OMA" id="MMLVGDI"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000047">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD70078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="450" mass="48612" checksum="E2580ACC2E694D8C" modified="2013-05-01" version="1">MRNIVVLGGTSHPQLTETICNHLGIPKAKVLLDKFKGGETRVEIQESVRGKDVFIIQSGGGKVNDHLMELLITISACRTASAKRITAVLPLFPYSRQSDIPYNKTGAPLSKVPGRSRTGTYSLESRPQTPHPGQPESAGLANGSASLHHQLSKIKLDERNGITSNPSSPVKTNGIKRTDTLDSTKGDKAAYFGTDHATNGVNGTNGTQTPGALARQTTITKPPAFEPQVGYRQWVAQAGTLIADLLTCAGADHVITMDLHDPQYQGFFDIPVDNLYGRHLLRKYIQFNIPNYQQAVVVSPDAGGAKRATAIADALGMPFALIHKERRPTQISDRQNATMMLVGDVSARTTILIDDLADTSNTITRAAKLLKKEGATQVIALITHGILSGDAIDRINASALDKVIVTNTVPQDEHKSRCPKLEVLEVGNVFAEAIRRVHHGESISVLFDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSD5</accession>
    <name>M2SSD5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_164153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704250.1">
        <property type="nucleotide sequence ID" value="XM_007706060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSD5"/>
    <dbReference type="GeneID" id="19132295"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164153"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="GFTTMMQ"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD59991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="497" mass="56553" checksum="FEAD30342533E827" modified="2013-05-01" version="1">MFGKTEKHPPSPELDKQDALPRYDNNHDDDSEHVTCPPTTTDTKLIAKIDLHVIPFLCIMYLLAFLDRVNIANANVFGLSQELDLNRDNRYNTALVIFFVPYILFEIPSNILLKKMKPRIWLSICMFGFGLVTMLQGFVQNYAGLLTTRFFLGVFEAGMFPGAFYLIGMWYRRNEAQKRFSFFFSSTTLAGAFGGLLASAIGKMDHMRGYRGWRWIFILEGLLTVVVSFAFFFLLPNFPEEVKWLSEPERAYVKHRLQVDQGRSARERPIKARDVGNVFKDPKIFIGGLMYFGLIVPAYGYAYFSPAIIQGYGYSPIQTQLHSVPPWAAAFGFAMLVAYFSDRLRHRFLFAIFPICVCITGFAILISVHNNHDLQYAALFLVAMGAYTAMPVIVCWFNMNLGGHHRRAVGSAWQVGFGNIGGIIATFSFLKKDAPKYTKGYSISIAFVVLSALSCTAYFIMCNWANRRRNKSVRDVGLTEYEKTEMGDLNPDYRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSU8</accession>
    <name>M2SSU8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_346648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704348.1">
        <property type="nucleotide sequence ID" value="XM_007706158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSU8"/>
    <dbReference type="STRING" id="665912.M2SSU8"/>
    <dbReference type="GeneID" id="19137787"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_346648"/>
    <dbReference type="eggNOG" id="ENOG502SD7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_4_0_1"/>
    <dbReference type="OMA" id="THFRGTM"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="52"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="279" mass="30793" checksum="65F5EE8F99C86508" modified="2013-05-01" version="1">MSAQTALTHYIDVKGTTLAYRRFGTPSPFPLLWITHFRGTMDLIDTLLLNSIASTRSLILLDNSGCGHSSGTIQPTIGGAAATIADFLSAINVSKVDVLGFSMGGFTAQVLTLEYPQLVRKLVLAGTQSAYTTGFVAPDPNVMIKASQPDPTLDTMLDLFFYPSETSRALGAAWWHRLLERHVDGEQRTTFVDEAGAQVQNAAIAAFVSDAAFFQRMEELDMEVLVTNGKTDIMTPTPNSWLMQQKMKKAELYIFKDSGHGHLYQFPEKYARLLDLFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU43</accession>
    <name>M2SU43_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_99224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703700.1">
        <property type="nucleotide sequence ID" value="XM_007705510.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_99224"/>
    <dbReference type="eggNOG" id="KOG1807">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001066_2_0_1"/>
    <dbReference type="OMA" id="EWIMVEA"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="182"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
            <begin position="368"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="759"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="1106"/>
            <end position="1127"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1127"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1237" mass="139170" checksum="2ACFDA2315346810" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVB9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_235684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703159.1">
        <property type="nucleotide sequence ID" value="XM_007704969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVB9"/>
    <dbReference type="GeneID" id="19134866"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_235684"/>
    <dbReference type="HOGENOM" id="CLU_2687664_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="74" mass="8024" checksum="3C983A7C321DB7DD" modified="2013-05-01" version="1">MSNVTARKTGDSYAIWNTSHCAGKFGTYCNLQLSSSLAFQLDFSPRLGDERVVPSSKHIGAISLILPGSVFFQV</sequence>
</entry>
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    <accession>M2SVX3</accession>
    <name>M2SVX3_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_124634</name>
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    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703460.1">
        <property type="nucleotide sequence ID" value="XM_007705270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVX3"/>
    <dbReference type="STRING" id="665912.M2SVX3"/>
    <dbReference type="GeneID" id="19130601"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_124634"/>
    <dbReference type="eggNOG" id="ENOG502QQXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_4_3_1"/>
    <dbReference type="OMA" id="NVCDDQF"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="539" mass="60280" checksum="1EB4FCA8A071EB29" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVY5</accession>
    <name>M2SVY5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_192811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703352.1">
        <property type="nucleotide sequence ID" value="XM_007705162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVY5"/>
    <dbReference type="GeneID" id="19133824"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_192811"/>
    <dbReference type="eggNOG" id="ENOG502SN6Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008827_1_0_1"/>
    <dbReference type="OMA" id="EGCTGRW"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="77581" checksum="BF80C799A49CD5F6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWX1</accession>
    <name>M2SWX1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_95990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702710.1">
        <property type="nucleotide sequence ID" value="XM_007704520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWX1"/>
    <dbReference type="STRING" id="665912.M2SWX1"/>
    <dbReference type="GeneID" id="19141651"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_95990"/>
    <dbReference type="eggNOG" id="KOG1805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885680_0_0_1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="314" mass="33993" checksum="BD7F6B62E991D5DA" modified="2013-05-01" version="1">MAYHHRLQQSRSSAVQSCTGPDAADCWLSRSLSPDQPVVFINTDPISSTLETQAGPRITNALEARLVSQLTVSLLSLGVAVDEIGIIAFYRSQLALLRQGLAAAYTQTQSSELSALVISGQGCAGVELHTADKFQGRDKEVVIVSCVRSNENGIVGDLLKDRRRINVALTRARSKLIILGSEKTLSSNELLRDMVALCRGKDWVLDLQPNMVESHAFEEAITQTSKTPVRPSNYSSCVPDFAMSPSLTPSPCKKRKALGDLTTAPGTINARSSKKQIGSKSPEAKKVPTKVFTVGKRGILDGRPVLRDIYNDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXK1</accession>
    <name>M2SXK1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_148612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <begin position="22"/>
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            <end position="64"/>
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    </feature>
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            <begin position="121"/>
            <end position="131"/>
        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD67300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="68" mass="8142" checksum="6563883C66E147D8" modified="2013-05-01" version="1" fragment="single">RCASCIFVAADCNLHTSEQDWEKFQREYHELELQIARLKLHLTQSKVELLELQDREHSYAYRDLVLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZD8</accession>
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025486" description="Autophagy-related protein 27" evidence="3">
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            <end position="265"/>
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        <location>
            <begin position="212"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29584" checksum="8AABF5C6014DFBBF" modified="2013-05-01" version="1">MSFLLVRALLCPFSLLFLLLVSADSTSHCFRQQENGYARTTVQCIQQPSLQLQLPLLYLLADGTPCVVQLQHIEPGLCGDNFMRFETPRVFELLFVEASSQTDHQRRSTSPLNAAQAASQDQHMPGVDRAQGCTSSRRSNPRRRLCQRNPLQVKQYGPSKLGGLGCAAGREGVKSLRVHFAAYASCHARAHTTLTILTGFLQTRRLSMSKDLGYIMALIVLSFALLKGVGIAHSERTKTDFLPQAERSNYRPVETSIRTDHHHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZV9</accession>
    <name>M2SZV9_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_161921</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701721.1">
        <property type="nucleotide sequence ID" value="XM_007703531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZV9"/>
    <dbReference type="STRING" id="665912.M2SZV9"/>
    <dbReference type="GeneID" id="19132137"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_161921"/>
    <dbReference type="eggNOG" id="ENOG502SBYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076390_0_0_1"/>
    <dbReference type="OMA" id="HPTRELM"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23622" checksum="06E10F362CCB3530" modified="2013-05-01" version="1">MGATRPHEGGSKSSSKSKDTKKKKGFAIGPANLPDGTHRRKIEKIKKSLIDKAKIKKQYAKLKAREEKEAVNPPKSVYDREASTEQGDKVSPEPTAEPTLEPHPDRAVLLEEKSPEPERQQNFERRQRRPRPQPFQKESLLAQKKKDEAEARRKAKEEADRERAKKAAERERFRKTMAKARGGPNGQRKLGRESTVLLAKAQRLMGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2T049</accession>
    <name>M2T049_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_32905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695401.1">
        <property type="nucleotide sequence ID" value="XM_007697211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T049"/>
    <dbReference type="GeneID" id="19136951"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32905"/>
    <dbReference type="eggNOG" id="ENOG502RVZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049918_2_0_1"/>
    <dbReference type="OMA" id="AYCFYEI"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="306" mass="34827" checksum="AE5A5FD872F66A8D" modified="2013-05-01" version="1">MSARPTYSQPQIARYFDRLKLPQEQRRYRVAGLPDADILNYLTLLQKLHLAEIPFENFALHYSTHHSVSVHPEQLFNKIIGDNNGRGGYCMENNCLFGTLLTSLGFTLYSGAGRVFEGTSSGGWMHYINFVTIGDIKYHVDVGFGGDGPIAPMPLDPTGTVQKHIQPASARLQWRNIPGNVDPNQRVWVYEYRRSDASDWEMKYAYSELEFQPQDYVAMNYFTSTSRHIFFTSKIIAHKNILEDGELIGKMSMVAATLKWNIHGEKTKEIEFKSEAERVEGLDKYFGIKLTQAERDGIAGMPSEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0G6</accession>
    <name>M2T0G6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Alpha-amylase</fullName>
            <ecNumber evidence="4 14">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_221707</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 14"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701867.1">
        <property type="nucleotide sequence ID" value="XM_007703677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0G6"/>
    <dbReference type="STRING" id="665912.M2T0G6"/>
    <dbReference type="GeneID" id="19134601"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_221707"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_2_1"/>
    <dbReference type="OMA" id="IWWQVYP"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF212">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
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    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Starch-binding domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025529" description="Alpha-amylase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="17">
        <location>
            <begin position="482"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD62517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="587" mass="63176" checksum="8C68CDD245B35F5C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2G5</accession>
    <name>M2T2G5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_182468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2G5"/>
    <dbReference type="GeneID" id="19133360"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182468"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_2_0_1"/>
    <dbReference type="OMA" id="AWWLWAT"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD63207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49172" checksum="D6AFD86BD2657176" modified="2013-05-01" version="1">MADDHKVSSIESASDVDDQKRDHPVRWYRSTFFNITILGLCNFSAPGIWGAMNSLGAGGSQSPHLVNAGNALTFCLMVVSCYFSSVIVKYIGIKGALIFGTIGYAPYAAALYTNNRFGTEWFIYLGSSLCGISAGVFWMAEAAIAIAYPEPWNKGKALGYWLTYRLGGQILGGAINLGLNSKRDQAGKVTYTVYLIFIALQCVGPVVGCFLNSPDKVERKDGKKVELKIAKDPWFEIKETGRLFFTKKFLLIVLWIGQAVFAEAVFFTYLALWFSVRARALGSFLSGIIAVICGNLLGAYLDRTSIALRIRARTSFITIATLQGAWWIWATVLATEFRNSRPTYDWVSDGFGRAFAVFIFLTIGFQINYLFLYFVIGNLAENEEEVIRYAALLRGTESAWQAVSYGITSIKVFAEVGAIYWNFALWGVSLWPAWLVIRGLARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2K1</accession>
    <name>M2T2K1_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_120457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701458.1">
        <property type="nucleotide sequence ID" value="XM_007703268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2K1"/>
    <dbReference type="STRING" id="665912.M2T2K1"/>
    <dbReference type="GeneID" id="19130448"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_120457"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_7_2_1"/>
    <dbReference type="OMA" id="AYSEPQT"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="438" mass="47279" checksum="F5928CCDCBB63A61" modified="2013-05-01" version="1">MSFAITSAAGLARLSPAPRRASSTGFFLLALSASPLVAPASTSRSPGVPLQRMPPHAHPTCPLNRNTSPATVGLRSFHSSSHNWRSMPQYTYHVAASYSAKQDNFDAEQNLFTRPLYDPRKSKIEDLRECKEAIDKRKRAKSGQDAFFFSQVGTTDTTTFGVADGVGGWVESGLDPADFSHGLCEYMACAARSWPHGFNTTSLHPKDLLQVAYDEVTDDASIEGGGSTACLAVAEPDGHVEVANLGDSGFMHLGLNAVRHFTQPQTHAFNTPYQLSKTPQRMLVQMAVFGGPTTLSDLPKESSVTHHKVRHGDVLVFATDGVWDNLSPQDVLGIVSRQMVDLGAWVERDGTIVVGKNLAKLVQADSSRKADSSSLQAKVAVAIAKEAKVTGLNTRRDGPFAREVQRYYPGENWHGGKPDDIAAVIAVVLEEASPRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2K6</accession>
    <name>M2T2K6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701075.1">
        <property type="nucleotide sequence ID" value="XM_007702885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2K6"/>
    <dbReference type="STRING" id="665912.M2T2K6"/>
    <dbReference type="GeneID" id="19139169"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38118"/>
    <dbReference type="eggNOG" id="ENOG502S2H7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033724_0_0_1"/>
    <dbReference type="OMA" id="WGIKKDP"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001244">
        <property type="entry name" value="HCP-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38906" checksum="E7D61CB0F56F92F9" modified="2013-05-01" version="1">MTLKDLLKKKDKIRDDGASPASPTGATLSPNVPEFQFVRTTTSTQETIEPPSFPGDPQRDSPLLSPEPRGKFPRFRSRSNASSQGSTSGGEWHRFQLGRSKSNASANVPDNLPEVGGDGVARTEEEEAKWEKRATVLVTSGLQHGSQPSTPSHVPKSPMSQGRPTTPRRRSTTIGAPADEETIQEAIRQHEHGDLEASTSLFGKLADPNGANNALAQVLYGLALRHGWGCESNQEQAVQYLSMAASNSAEVEKLALGAGMKKGGAAKGELVLAMYELANCFRNGWGIKKDPRAAKQYYETAANLGDTDAMNEVAWCYIEGFGTKKDKFKAAQFLRLAESKGNKTLGNTWIWKDKYNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2U1</accession>
    <name>M2T2U1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_200080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700612.1">
        <property type="nucleotide sequence ID" value="XM_007702422.1"/>
    </dbReference>
    <dbReference type="GeneID" id="19134124"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_200080"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241941_0_0_1"/>
    <dbReference type="OMA" id="WYGCESV"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1209"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1274"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1305"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1336"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1371"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1406"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1489"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1531"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1572"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1596"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1629"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1663"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="457"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="947"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1217"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1090"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1145"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD63521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1702" mass="187417" checksum="63CA7A4BA868887D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3A8</accession>
    <name>M2T3A8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_33788</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695628.1">
        <property type="nucleotide sequence ID" value="XM_007697438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3A8"/>
    <dbReference type="STRING" id="665912.M2T3A8"/>
    <dbReference type="GeneID" id="19137307"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33788"/>
    <dbReference type="eggNOG" id="KOG3408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117291_1_1_1"/>
    <dbReference type="OMA" id="MKDHFRS"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD68925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="121" mass="13566" checksum="46C632262F6300C1" modified="2013-05-01" version="1">MPAIRGQDSKKKTRRHTRDLDQIHADLRDEKHLAAFKNEKPIEDLPGLGQYYCKECAKFFESDANLGAHQKGKVHKRRVKQLLEEPYSQKEAEAAIGLTTNNGTRTTAPAAPMEVDQVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T445</accession>
    <name>M2T445_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_36606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699745.1">
        <property type="nucleotide sequence ID" value="XM_007701555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T445"/>
    <dbReference type="STRING" id="665912.M2T445"/>
    <dbReference type="GeneID" id="19138773"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36606"/>
    <dbReference type="eggNOG" id="ENOG502QS1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014631_0_0_1"/>
    <dbReference type="OMA" id="VPNKSIM"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="933" mass="101455" checksum="F045A8A2AAAA85EB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T493</accession>
    <name>M2T493_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2461 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_105516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694630.1">
        <property type="nucleotide sequence ID" value="XM_007696440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T493"/>
    <dbReference type="GeneID" id="19129973"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_105516"/>
    <dbReference type="eggNOG" id="ENOG502RKMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036742_0_1_1"/>
    <dbReference type="OMA" id="GVMEPFV"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46827" checksum="62D6230668C49DAA" modified="2013-05-01" version="1">MPRKSTKEAKSTAPRSSSKRPAQETPQRQSKRARATARKSYVDPGTDTDDADEKSARKVSSSADEQDGAASDYEHHDNKESSVGSEADVTDSDEDDESKDHQLRGRAAKSLPIHKKISDEQELWKPGAKLEPGTRVVIKKPKARDAGDTPYLDHTIHPNTILFLKELAANNDRSWLKLHDPDFRVAFQDFTTFAEKVSEKIIEADETIPELPVKDVIYRIYRDIRFSKDPTPYKTYFSAAWSRTGRKGPYAHYYIQVQPKGGSFVGGGYWQPDAAALAKLRHDIDRKPHKIKSVLRNRNFRETFLGGVQDDDKKAVKAFASLSMNQSNALKRNPKGYDHDHKDIDLLRLRNFTIGRTVADEVIVGTSGLERVAELVMAMVPFITYLNSVVMPDEEDTSGSSSEDEDDADDGADEEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4X1</accession>
    <name>M2T4X1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_177223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694790.1">
        <property type="nucleotide sequence ID" value="XM_007696600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4X1"/>
    <dbReference type="GeneID" id="19133072"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_177223"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="OMA" id="MMPGVSH"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF147">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="518" mass="58553" checksum="E63455A50F146350" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6C6</accession>
    <name>M2T6C6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_314531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699354.1">
        <property type="nucleotide sequence ID" value="XM_007701164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6C6"/>
    <dbReference type="STRING" id="665912.M2T6C6"/>
    <dbReference type="GeneID" id="19136440"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_314531"/>
    <dbReference type="eggNOG" id="KOG0673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD64781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="335" mass="37510" checksum="B8D609C38D967BFB" modified="2013-05-01" version="1">MTATTIDPETSPQTQKPPPPPSNPAHEEHQYLSLIRDILQNGEHRPDRTGTGTYAIPFPAQMKFALSHPSADPTQPPQLILPLLTTKRVFLRAVIGELLWFISGSTHSKPLSDAGIKIWDGNGSRAYLDSVGLSHYEEGELGPVYGFQWRHFGAEYKGHAHDYTGEGVDQLAEIIDKLKNKPYDRRIILSAWNPADIKKMALPPCHMFAQFYVSFPGHKQGEERPRGVLHSLLYQRSCDMGLGVPFNIASYALLTHMLAHVCDLTPGTFTHTMGDAHVYLDHVDALKVQVEREPREFPELRIKREIGGSIDGWLESEFEVVGYKPHASLAMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6V9</accession>
    <name>M2T6V9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_116241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699509.1">
        <property type="nucleotide sequence ID" value="XM_007701319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6V9"/>
    <dbReference type="STRING" id="665912.M2T6V9"/>
    <dbReference type="GeneID" id="19130320"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116241"/>
    <dbReference type="eggNOG" id="KOG3067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079179_0_0_1"/>
    <dbReference type="OMA" id="DAFHFTI"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27688" checksum="6219625170CFCEA0" modified="2013-05-01" version="1">MASQSGMVNPAVFQDLQARIDEDSAVRDELRDIIQALEKHNRNVSFVLSRAHSTPVSELSEILKAAQEPIDNVIDTVSKLSQAASKMPYYKFNNMWSRQMQGACESILFWGWLGGYKYEGGAVQCGRLLTIEELGEIFKIPVNLKERDEFHLSLEEYLHSLMTLVEELTRLARNAVTLGDYERPLLINQFVKDLHAGFQILNLKNDSLRRRSDGLKYRVKDVEDVVYDLSLRNLVPKKGEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T721</accession>
    <name>M2T721_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_342382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695321.1">
        <property type="nucleotide sequence ID" value="XM_007697131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T721"/>
    <dbReference type="GeneID" id="19137539"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_342382"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_4_1"/>
    <dbReference type="OMA" id="FETQFTR"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="81"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD70215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="555" mass="61018" checksum="25FD6CB87451C760" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2T755</accession>
    <name>M2T755_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_317618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699569.1">
        <property type="nucleotide sequence ID" value="XM_007701379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T755"/>
    <dbReference type="STRING" id="665912.M2T755"/>
    <dbReference type="GeneID" id="19136514"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_317618"/>
    <dbReference type="eggNOG" id="ENOG502T2QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1695309_0_0_1"/>
    <dbReference type="OMA" id="GQATTCE"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="155" mass="16886" checksum="BFD7DF581BF3A59C" modified="2013-05-01" version="1">MSDTPIPITTQQAQSGISRDLRNNIYSALLAGPGIRNIEATLDESLRSSGFKDALRAYITELFRSGQATTCEEARNLAMQRIREHTRQLDGNSSSSKKQSATNGLSDDQLNGGDGTADDALEFDLKIPKSAIDAGAKTVMKELEKVCEITYEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2T838</accession>
    <name>M2T838_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G protein alpha subunit AGA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_317953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699591.1">
        <property type="nucleotide sequence ID" value="XM_007701401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T838"/>
    <dbReference type="STRING" id="665912.M2T838"/>
    <dbReference type="GeneID" id="19136522"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_317953"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40859" checksum="AC0DB7125A5A833C" modified="2013-05-01" version="1">MGCGMSTEEKEGKQRNEEIENQLKRDKLMQRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDERESFKEIIFSNTVQSMRVILEAMESLELPLDDQRAEYHVQTIFMQPAQIEGDSLPPEVGNAISVLWKDAGVQQCFQRSREYQLNDSAKYYFDSVDRIAAPDYIPNDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGPDYAAACDYILNRFVSLNQHETKQIYTHFTCATDTMQIRFVMAAVNDIIIQENLRLCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2T880</accession>
    <name>M2T880_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_318511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699629.1">
        <property type="nucleotide sequence ID" value="XM_007701439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T880"/>
    <dbReference type="GeneID" id="19136550"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_318511"/>
    <dbReference type="eggNOG" id="ENOG502SQ3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915600_0_0_1"/>
    <dbReference type="OMA" id="GRGWFLI"/>
    <dbReference type="OrthoDB" id="3880384at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="298" mass="33820" checksum="88CFF810B578ABE3" modified="2013-05-01" version="1">MAPNLFVATQKAFFPHKWFKSSKVDLSRVVEEWNSPVPGQYESIPGRGWFLIATLKDASKPEGNNKSTIKGSDGKDYIPLETPIPLKYSHALGRYFLEPEFYKRKKTVMIKDDKGKEVRAGFFRVDDVAWVKCWDEHDTFIPGNANGAAGYQRWVLDAQTQQFRHMIKRDDPNYVRSRRNSPARDADNRSQESVSTEFRPSRPSSTKNGFSVASTRANSIRYQPSTPTSNAPSQRPSRQNSPKRSDSIPLEEAKAALRRLAREHEEAAAALARSRMKRTDSTDGVEQIERGRVSERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9B9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698256.1">
        <property type="nucleotide sequence ID" value="XM_007700066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9B9"/>
    <dbReference type="STRING" id="665912.M2T9B9"/>
    <dbReference type="GeneID" id="19135226"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_25148"/>
    <dbReference type="eggNOG" id="ENOG502SNPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1102688_0_0_1"/>
    <dbReference type="OrthoDB" id="3687741at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="252" mass="28096" checksum="693AB6F409F655CC" modified="2013-05-01" version="1">MHSSNKSQLGNYNKKLDLDWDTKVAILDGLVNPNTIRSDITPSCSTGNSSIRNVSIVTFTNHGCEPLGQENGSEFQQCPGADASWTFPIMNFLNAVAATCSFYSCVRDYAGTVRNTTFTETVINETPIKAARSSMDDNVYDFKDLIHARSLGKFMDSIMNGKCSAIPGIDPEFYKNDYKTLRCYPWQLEALVNTGLASFDTIDRNMQSVAMAIMSDMRRKGSYYNPEYPITSPIFVTGTVMCTTNCTKFDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAD7</accession>
    <name>M2TAD7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_85259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697717.1">
        <property type="nucleotide sequence ID" value="XM_007699527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAD7"/>
    <dbReference type="STRING" id="665912.M2TAD7"/>
    <dbReference type="GeneID" id="19141050"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_85259"/>
    <dbReference type="eggNOG" id="ENOG502T0XX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109060_0_0_1"/>
    <dbReference type="OMA" id="WIQERLM"/>
    <dbReference type="OrthoDB" id="4509729at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="172" mass="19337" checksum="607AB85DA97BD4E6" modified="2013-05-01" version="1">MSPMSRPALCRHQSMQKYMLLSAQKEALQRRMAMEIPFNAPMTPSSPEFQSLSSSPTSPKYSSPFPTASDPIPVSSRTNATPRTSVDDIHTEESQKLAEINQQIVATLTELLNTDCIRNDEKQRAWIQERLMEAEHQIRRERRRHSSNAGGGFASAIAQHLELGLNTSKTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAS7</accession>
    <name>M2TAS7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_35926</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698432.1">
        <property type="nucleotide sequence ID" value="XM_007700242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAS7"/>
    <dbReference type="STRING" id="665912.M2TAS7"/>
    <dbReference type="GeneID" id="19138610"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35926"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="7"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD65992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="357" mass="38453" checksum="248AC05697189240" modified="2013-05-01" version="1">MAARTLRIGLIPGDGIGREVIPAGRRILEALPSSLGLKFSFSHHEAGWETFQKTGAALPDKTVEALKSDCDGALFGAVSSPTVQTKGYSSPIVALRKKMKLYANVRPVKSVRGGLRDVDLVIVRENTEDLYVKEERTYTAPDGSKIAEAIKRISETASFNIAAMAGDIALRRQRVRDAGGNSIHSRPLVTITHKSNVLSQTDGLFRETSRRALQDAKYQMVGVEEQIVDSMVYKLFRQPQDYDVIVAPNLYGDILSDGAAALVGSLGLVPSANVGKDFVIGEPCHGSAPDIEGQGIANPIATIRSTALMLEFIGEEEAAAKIYSAVDANLEQGELLSPDMGGKAKTDEIIEDICKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TB95</accession>
    <name>M2TB95_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_197647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697697.1">
        <property type="nucleotide sequence ID" value="XM_007699507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TB95"/>
    <dbReference type="STRING" id="665912.M2TB95"/>
    <dbReference type="GeneID" id="19134028"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_197647"/>
    <dbReference type="eggNOG" id="ENOG502S40X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053381_1_0_1"/>
    <dbReference type="OMA" id="CQNGMVM"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025790" description="Phytocyanin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="24229" checksum="E7DDC66E3EBC8B3D" modified="2013-05-01" version="1">MYFSTTAIVSAIFGLAAAQGGMLKMHVVQVGGPNGSLAFYPNNVAAQPGDMVQFQFHPKNHSVAQSTFDNPCIPIQNIMPNKTDAFFSGFMPTNASFTATNQVLTYTIRVPDTKPIWFYCSQGKHCQNGMVGAINAPAAGNKTIQAFTALAAQASENLSPGQPAGSGGITGNTPTSPSPGNGADSGNGQGGAGAGGSGAGAGAGAGSGTGASPPQTTTSSASGLSAQSFISVAAAFVAITFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBD8</accession>
    <name>M2TBD8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_137527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD66182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699546.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19131054"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137527"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484840_0_0_1"/>
    <dbReference type="OMA" id="PQNMAFF"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NmrA_like_SDR_a"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
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    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
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    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR42748:SF28">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="ADH_SHORT"/>
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    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="243"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD66182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="562" mass="61781" checksum="D60650D0703550E0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2TC36</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_198141</name>
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    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698157.1">
        <property type="nucleotide sequence ID" value="XM_007699967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TC36"/>
    <dbReference type="GeneID" id="19134054"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_198141"/>
    <dbReference type="eggNOG" id="ENOG502SSF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162157_0_0_1"/>
    <dbReference type="OMA" id="FMAKHKA"/>
    <dbReference type="OrthoDB" id="4415650at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="117" mass="12989" checksum="E02758282EEEFA90" modified="2013-05-01" version="1">MSSSTHLPLLFTLPPSSRHDFLLLDTSAKISLKALNKQITSTIASSPNCTEFMAKHKAKDGPAEQIQEFKIHWDVKGREKLWPEYTVLTEDNISAVVELLKGNPGMGVLEVKLGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCB7</accession>
    <name>M2TCB7_COCSN</name>
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        <recommendedName>
            <fullName evidence="6">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_112859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697949.1">
        <property type="nucleotide sequence ID" value="XM_007699759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCB7"/>
    <dbReference type="STRING" id="665912.M2TCB7"/>
    <dbReference type="GeneID" id="19130197"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_112859"/>
    <dbReference type="eggNOG" id="KOG3277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093902_0_0_1"/>
    <dbReference type="OMA" id="HADSTPK"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD66462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="202" mass="22248" checksum="1925780AE82B8E26" modified="2013-05-01" version="1">MRSSPSLLRAFARSAVLRTRPNVTAGCIPAPAKRFLHTRQSLTALRPAPAPLRAPVPSTVRFESNTAAPTSTTAPDSRLERDQVPSYELTFTCNVCKTRSSHRLSKQGYHHGTVLIQCPGCKNRHLISDHLKVFSDKSLTIEDLMREKGSLIKKGSLSAEGDVEFWDDGTSTPRSAHFHADSMPKGDNRLSQLPDPPKPPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TD78</accession>
    <name>M2TD78_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_34052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696525.1">
        <property type="nucleotide sequence ID" value="XM_007698335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TD78"/>
    <dbReference type="GeneID" id="19137419"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34052"/>
    <dbReference type="eggNOG" id="ENOG502RIXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047025_0_0_1"/>
    <dbReference type="OMA" id="ATVMMMQ"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="502" mass="56728" checksum="8AF44C8D4D2AF299" modified="2013-05-01" version="1">MATHKRSRTGCWTCREAGYKCDEQKPFCGRCMRLKITCKGYGVRLKWQEGAVSTLTKPRKSRKKKALEQDFALSPASVNSFSSMPLIVSTPENTLSSPGSTKSLPLLPLNSPGLSYGLSPDDRWLLDYWVDRLSTLISVTPNMGISTPFQRHLTAMACESAALRSTILSMAANHLATSSKDRFLYFQRYRHQRDAICELQRMIQDPSEMNAEPALATVMMMQVSARLFGEDDEECVANHLTGAKAMIVRSQGEDWLVSSRARFLMSIFAYHDILSSVSRGSNPLLDHETDFSAIEGEESLASIANVLLVVAQISQLQHTIKTRRSRSPTSPALSENENTTGRHIQQKLLAMDFTICKQENVQESADIKLTAEAYRHAAFIYLYRTWLDIGAPNPISMDHINQCLAYLQKVDVRSPLTTSHIWPLFTAGCEAIDSTQRQFVRDRFEEMYAVKRFPSLRRVMRDIEHVWEAKDIEQEMKGKDGMAKVDCIQVILKKRGREVDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFA1</accession>
    <name>M2TFA1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_32890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD67921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695398.1">
        <property type="nucleotide sequence ID" value="XM_007697208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFA1"/>
    <dbReference type="STRING" id="665912.M2TFA1"/>
    <dbReference type="GeneID" id="19136945"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32890"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_3_2_1"/>
    <dbReference type="OMA" id="WIRNISK"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="200"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD67921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="589" mass="65334" checksum="0C1E4EE993254716" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2TG22</accession>
    <name>M2TG22_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_133651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695867.1">
        <property type="nucleotide sequence ID" value="XM_007697677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TG22"/>
    <dbReference type="STRING" id="665912.M2TG22"/>
    <dbReference type="GeneID" id="19130896"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_133651"/>
    <dbReference type="eggNOG" id="KOG2189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005230_0_2_1"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="781"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="854" mass="97460" checksum="68DCA86D58D2903B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TG59</accession>
    <name>M2TG59_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_167486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695896.1">
        <property type="nucleotide sequence ID" value="XM_007697706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TG59"/>
    <dbReference type="STRING" id="665912.M2TG59"/>
    <dbReference type="GeneID" id="19132519"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167486"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD68231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="253" mass="26903" checksum="D2F10D82493BFAD3" modified="2013-05-01" version="1">MTTELENGLPANGTNGVNGNATETINSTPSHPAFDSISDVIQAFANDEFVIVLDSPARENEGDLIIAASALTPSKASFMIRYSSGYICAPLPVSRAAALHLPQMVADNADPNRTAYAVSIDAADPSVTTGISAHDRSLTCRMLADPSAKASHFRRPGHILPLQARDGGVRERMGHTEAAVDLCRLAGKEPVGVICELITDGEEVPGKPELKNGGMMRRDECLAFGKKWGIKVCTIEDMVKYIEENEGVLGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI92</accession>
    <name>M2TI92_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_33339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695518.1">
        <property type="nucleotide sequence ID" value="XM_007697328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TI92"/>
    <dbReference type="GeneID" id="19137140"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33339"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="OMA" id="CALYACI"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="116"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD68427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="580" mass="63044" checksum="502D438BC2798B3E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLC2</accession>
    <name>M2TLC2_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_132286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695121.1">
        <property type="nucleotide sequence ID" value="XM_007696931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLC2"/>
    <dbReference type="STRING" id="665912.M2TLC2"/>
    <dbReference type="GeneID" id="19130841"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_132286"/>
    <dbReference type="eggNOG" id="ENOG502RDJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008050_0_0_1"/>
    <dbReference type="OMA" id="RIEMTYY"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="44376" checksum="07BA7EAD72D9C005" modified="2013-05-01" version="1">MAGFGRSNSLSINTGGGGGLFGSNASTQQQTPQQPQQSGSLFGNLNKPATTTPASAGLFGASTAQPTQPQSGGLFGGALGGNTQNQAQNTTQSSGLFGGAQSKPSLFGASTQPATTPSLFGNNTANQQNQTSTPSLFGSTQQQPQPQQQSTLGGGMNFPNRSNTLGGSTLGGTQMGASAQPVQLTLDSIRGTTRFNDLHPELQTLIQQFDEGVQRKINYCSQIRESLPGNERDISSIAPDVAYIETFLSTVEVGLDNDSANIAHLKSLVKKDADDATLSFRAIENQRLPAQFHYRNNGNLTASSAKTPATSALDDDDPTKPVDLMNYFDRRTDELGRTLDVYQRQIREIEAHLRTMEAGTVEKAQQLTGSRSAPRDQRRELVEALKAIEGAILDSAKKVGQVRDDVTKQTLGSVGAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2TN70</accession>
    <name>M2TN70_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_53821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694405.1">
        <property type="nucleotide sequence ID" value="XM_007696215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TN70"/>
    <dbReference type="GeneID" id="19140302"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_53821"/>
    <dbReference type="eggNOG" id="ENOG502R2Y4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110779_0_0_1"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD70132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="166" mass="19311" checksum="24620CC72359E107" modified="2013-05-01" version="1" fragment="single">VSPFLRGMEHYSKVVEMLCNGTPYLAWIWAPFVLLIVYQQIAVDSINAFEKSIEAYGKIADMLPRLDRLSHALADDHNFQNFFALVYFDIVEFHWRAYKFLCHVVLYSQLIAWAIFFSSMWVGFEYRFNGILKNLAYHGGLVEKEAAAAEISEAVRRSKADDEKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2QY49</accession>
    <name>M2QY49_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_151187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704246.1">
        <property type="nucleotide sequence ID" value="XM_007706056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QY49"/>
    <dbReference type="STRING" id="665912.M2QY49"/>
    <dbReference type="GeneID" id="19131550"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_151187"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020262_7_0_1"/>
    <dbReference type="OMA" id="YLFHEDN"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000089">
        <property type="entry name" value="NIF domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="275"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="467" mass="51715" checksum="1D4BEC6DE5E37E80" modified="2013-05-01" version="1">MGANRSNGSGSSTTEAVASGSNEKSPLLQQSQKGPYDDTTRRRRWLYPQLLSDGLTAIVGVLATPFVYTGHYLIACFYYEDGHFSFLAPVYHVSRTFTRRRRKRVDAHAARASAATDSNEKAMRKGRSSSIAQPMTIQPSRRSLSIASTSTAMTSDSETEKPASHGGDWDSHSQHTRSKSSALSRADEIAPAKRSIRITLHHNEDVLRQRKAAKKAQSSKSNYTSSEAAASLKSPTGPATASSKQLTKFPRAPQPPRPLVPRRQPSYSAKGTSAVGPHQKTLIIDLDETLIHSIVNGGRFQTGHMVEVKLQASIGADGQVIGPQVPLLYYVHKRPYCDDFLKKVSKWYNLIIFTASVQEYADPVIDWLEVERKYFAGRYYRQHCTVRNGAYIKDLAQVEPDLSKVMILDNSPLSYVFHPDNAIPIEGWISDPTDHDLLHLIPLLEGLQYVTDVRALLALRLGMPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2QY82</accession>
    <name>M2QY82_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_346457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
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    <dbReference type="GeneID" id="19137777"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_346457"/>
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    <dbReference type="OMA" id="TRDTNSW"/>
    <dbReference type="OrthoDB" id="10311395at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60009.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="108" mass="11985" checksum="71796414DA82FC75" modified="2013-05-01" version="1">MAFDVLFLTRFSFAACFNRGLHDALCGTLPRLSASPHAAVLKTFISTHIALVIALVVFFSSTWSFSRVGRPVHFARRTNVGETTYTRDTNSWEQGGGFADRLIDLDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZZ2</accession>
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            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
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    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_184393</name>
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    <organism evidence="6 7">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD60629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007705740.1"/>
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    <dbReference type="STRING" id="665912.M2QZZ2"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_184393"/>
    <dbReference type="eggNOG" id="KOG3380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="LWHEKAF"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
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    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04699">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="186" mass="19895" checksum="BC35376DC226C805" modified="2013-05-01" version="1">MATVNWRTINIDALDPDSPANFDLSSLVPAVAPVSTADVQNNAQQIRQQLRGGDNEGALQSALENPPYGADDKGKETYLAVVIEILQSIRQSDMSPILSRIYSSPSGTETLDVLMKYIYKGMAQSTPAATTRNITPQPTGFSQIHARGGGEGGGQAMSVLLSWHEKLVDIAGPGSIVRVMADRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2R0P5</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_236940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703254.1">
        <property type="nucleotide sequence ID" value="XM_007705064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R0P5"/>
    <dbReference type="GeneID" id="19134896"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_236940"/>
    <dbReference type="HOGENOM" id="CLU_2558153_0_0_1"/>
    <dbReference type="OrthoDB" id="10300747at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="82" mass="8986" checksum="5E48634E9B6C61FA" modified="2013-05-01" version="1">MHSSATRFHSFTRISASDRLITTRSRLIAHSSSMADPNPRLQTLLPASCCRARGIGGVVGFVMCAEKCHLTKPLISKPCMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3M8</accession>
    <name>M2R3M8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_343326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD61809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3M8"/>
    <dbReference type="STRING" id="665912.M2R3M8"/>
    <dbReference type="GeneID" id="19137597"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_343326"/>
    <dbReference type="eggNOG" id="KOG0184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_0_1_1"/>
    <dbReference type="OMA" id="RVSMYMH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000044">
        <property type="entry name" value="Probable proteasome subunit alpha type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="290" mass="31512" checksum="55E06550CDE42D94" modified="2013-05-01" version="1">MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGGTALGIKCKDGVVLALEKLVSSKLIKPGANKRIATVDRNMGVVSSGLLPDGRHFVSRARDEAAQWRQLYKAPIPSSSLADRMGSYVQAYTLYSSVRPFGITAIIAGWDSEAELPVDGQVGSGPSVGSGGKREGAKHGGPSLYMIEPSGLYWGYYGAATGKGRQVAKSELEKLNLHEGQLSLEEGVKEAARIIYVAHDDNKDKEFELEMTWISNLDGPTKGRHEEVPKDIREEAERLAKKALEGDDDDDDEEEKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3W3</accession>
    <name>M2R3W3_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_225511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702271.1">
        <property type="nucleotide sequence ID" value="XM_007704081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3W3"/>
    <dbReference type="GeneID" id="19134668"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_225511"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_3_1_1"/>
    <dbReference type="OMA" id="HAGEVYI"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024500" description="Fungal lipase-type domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="123"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="402" mass="44705" checksum="0399B8CCEBE5C64C" modified="2013-05-01" version="1">MGSLRSLLLCYLTLATSWAASPQGDAKQQSLVRGTAKATGNNATIIPQDLFWELEELARIVDISYCVGTAGLGIKRPFTCASRCADRDFETFDLVKAWNTGPFLSDSCGYIALSHHPAEPRLIIAFRGTYSIANTIADLSTIPQEYIPYPGDDDSDSSDSDFLTPRFGVAEGVAEGDAPPAEPPKCENCTVHTGFYSSWLNTRRVILPYVSKALEKYPEYKLVLVGHSLGGAVATLAGLDFKARGWDPHVTTFGEPRLGNKEFNAYIDKRFNVTANHQHNKIHRVTHVGDPVPLLPLAEWGFSMHSEEIFISESSLPFSIADVQFCDGDEDMHCIAGSDEEKPAWGVPTRFKFWQFFFAHRDYFWRLGLCMPGGNPGDWYDKYPGHTMSDDTEVQEPEIQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M2R643</accession>
    <name>M2R643_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_93815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD63999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699740.1">
        <property type="nucleotide sequence ID" value="XM_007701550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RAW0"/>
    <dbReference type="GeneID" id="19138768"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36590"/>
    <dbReference type="eggNOG" id="KOG4730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_9_0_1"/>
    <dbReference type="OMA" id="FFPHGHA"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="487" mass="54989" checksum="33D657B6DA38B79F" modified="2013-05-01" version="1">MALYTYDTRPSFSADVLVRGTPEYDRCRRNNPSATTPERYPHEIHVVKSPKQVSAALKRATELGVTVGIRGSGHAFPLSALIEDGILIDTSSLNRYVDYDPDSREISFGPAVRVEEVAAKLAEVKRFFPHGHAPTVGAAGFLLAGGQGWFVRGWGATCQEWITQMEIVVPDGRVVIASPTENTDLFWAARGSGLGFFGVVTKFWARTIPSSQLWERTFTFQLRDKYETLLTWFFEKAEDTPKYGTDLNLTIFYPEKYDSTILTDDIPKTSQLHLGLSLLCYSDTEREARTLLSAYDDVPESVKDCLVDMRPVSKREFTDIFDKKREFIGNKYGENWQILSLLSEPTVPIPRLIEAIKPALTELETRITSVFICICDIVANEKVASLSIPQKYYISTVTGWLDQKKGPAIKQRMLDRYKRALPVACGTYPADYDPNVEDANSKPMSDTALAKFLKIRAKWDPNDMFPNYKQFIKTNEKINKLLTKPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBL8</accession>
    <name>M2RBL8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_322828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700091.1">
        <property type="nucleotide sequence ID" value="XM_007701901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBL8"/>
    <dbReference type="GeneID" id="19136715"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_322828"/>
    <dbReference type="eggNOG" id="ENOG502T0Y7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_725920_0_0_1"/>
    <dbReference type="OMA" id="GERCKYA"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024435" evidence="1">
        <location>
            <begin position="25"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="382" mass="41529" checksum="DFC7A9B22AF9DCFB" modified="2013-05-01" version="1">MLTLVSLYSLPPVLLSLVLTHAYASPDGVIGEQKTHVRPTFATALTGGEGCDLSEIDDIRDGFSEMVALFAAATPFDPTSQPGREFFGPSIAGNYTDMIAKNLQRAANYGVLNGEDGAINADIHIRCDDPMNLCDRGNRREGNHAAYNIGNEPHIVFCSDYFNMDPLEARINNKAEDQIQKDRLMEYYNRASLWARMVMHFSDIGTAVVQRPTPAPPNSTTEWIVTSSEGPMNTSVLAGVLNEQGDGPTDRQTLKYAYGATRAKLLATLSTQMPYDAANNAENYALYALSQYIIKDKTFYPAVPIMDFPNEASVLTNDNLQDGERCKYAFFDMSDVVARPSDMLLEGAPLPSTGSSSHALSSPMIGVTGAALVYAFMATSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2RDU6</accession>
    <name>M2RDU6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_159956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699495.1">
        <property type="nucleotide sequence ID" value="XM_007701305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RDU6"/>
    <dbReference type="GeneID" id="19131998"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159956"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="OMA" id="ICAHEDD"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="175"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="453"/>
            <end position="528"/>
        </location>
    </feature>
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            <end position="760"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ND90Pr / ATCC 201652</strain>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698237.1">
        <property type="nucleotide sequence ID" value="XM_007700047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RJH0"/>
    <dbReference type="STRING" id="665912.M2RJH0"/>
    <dbReference type="GeneID" id="19134057"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_198239"/>
    <dbReference type="eggNOG" id="KOG0412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006939_0_0_1"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="171"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD66859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1247" mass="138148" checksum="CE97015331E3E379" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RLW7</accession>
    <name>M2RLW7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_34396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AKT2 hydrolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696607.1">
        <property type="nucleotide sequence ID" value="XM_007698417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RLW7"/>
    <dbReference type="GeneID" id="19137633"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34396"/>
    <dbReference type="eggNOG" id="ENOG502RPSG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_1_2_1"/>
    <dbReference type="OMA" id="VDWQKRF"/>
    <dbReference type="OrthoDB" id="5382058at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013434303" description="AB hydrolase-1 domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="453" mass="49395" checksum="C9242249C97F3AB1" modified="2013-05-01" version="1">MKISTLSLFGLQATLGHAQESCNAACQAAFRPAVAAEIGSMVSKNVSSEAFYSTPANVTGAKPGDVLRWEDFPQSVVNTNFTIPSGMSLSRFLYMTEDIDRKPIPASGFVLLPYSRPDPSKPLNTIVWAHGTAGFTRNCAPSNHKDLYYEWQGPYYLAQAGYAVIAPDYAGQGSDIPQGFMYEAGFLHAADVAYSLVAARKVIGTLLSQDYVVIGHSEGGMTAWRTNERLAMPDQDELKKAGNFLGSVANSPALRPLDLIPESVRRANGGPIGDAVSVFFLQSLAGLFPKEFRIEDHLTPLALARVPLVNQGCIFAGRSLFAGLTSAQLFKSLDWLKLPVVVDWQKRFNGAGPHALAAPMLVVQGITDALTYANNTEWDFNQTCSSFPNSKATLLLYPDSNHDVNNNAPMVDFMRWIQDRFNGVPVQDGCHRKTIETLTTRLRNINTSYNGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2RLX1</accession>
    <name>M2RLX1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="9">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_352599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697220.1">
        <property type="nucleotide sequence ID" value="XM_007699030.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2RLX1"/>
    <dbReference type="GeneID" id="19138164"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352599"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001693_0_0_1"/>
    <dbReference type="OMA" id="WIGVHGK"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="11">
        <location>
            <begin position="955"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1473"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1477"/>
            <end position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD67609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1553" mass="172023" checksum="7A74A2E6D9A30482" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2RN36</accession>
    <name>M2RN36_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_33008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695433.1">
        <property type="nucleotide sequence ID" value="XM_007697243.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2RN36"/>
    <dbReference type="GeneID" id="19137000"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33008"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002330_0_0_1"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.690:FF:000003">
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="1042"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2009" mass="211574" checksum="BF4F637A0DF12C53" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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    <name>M2RNH8_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">COCSADRAFT_269901</name>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="342" mass="37749" checksum="F45708E481D1DFCC" modified="2013-05-01" version="1">MRILITGAAGFIGQLVAKKLLEDKNAAHSLILTDIIEPPVPKSTQSSNNVQAIRADLCTESSSVVTPDLDVVFIFHGIMSSGAEADFDLGMRANFDATRALLEAIRKISPGSRVIYASSQAVYNNSVTLPVTESQLPTPETSYGAEKMMCEYLITEYTRRGFIDGISLRFPTVCVRPGKPTAAASSFISGMIREPMNGIKCVIPLSDKQWRHWLCSPRILVQNLVHAATQFDTSRLATFDRVLNFPGIGVSIQDMMDSLERVGGKDKLALLEMREEEGLKRILESWPAEFDNRKALELGFQRDEGFDRIVRDYVESLGERMGEEQTGGKVEGVSVRTVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RNT1</accession>
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        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_33230</name>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695486.1">
        <property type="nucleotide sequence ID" value="XM_007697296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RNT1"/>
    <dbReference type="STRING" id="665912.M2RNT1"/>
    <dbReference type="GeneID" id="19137098"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33230"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_8_1_1"/>
    <dbReference type="OMA" id="LRQKSWI"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF162">
        <property type="entry name" value="RIBOFLAVIN BIOSYNTHESIS PROTEIN PYRD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="184" mass="20267" checksum="2CD2F95498ED70A2" modified="2013-05-01" version="1">MSTLLDWDGPTPPLPGPDPNDHLQYMRLALDQAQESPPKPSNFRVGALLVDADTGTILSRGYTLECEGNTHAEQCCLLKFAKAHNLPEERVGETLPPNTSIYTTMEPCNLRLSGNLPCADRIIRTKGANGEQKIKRVYLGVKEPEKFVGENQGRKKLEENGIECIHVPGLEDRILEVATAGHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RP00</accession>
    <name>M2RP00_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_167604</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695985.1">
        <property type="nucleotide sequence ID" value="XM_007697795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RP00"/>
    <dbReference type="STRING" id="665912.M2RP00"/>
    <dbReference type="GeneID" id="19132522"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167604"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="OMA" id="YVTRRRF"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024273" description="Mannosyl-oligosaccharide glucosidase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="16">
        <location>
            <begin position="30"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="284"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD68359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="832" mass="93590" checksum="B234DE21859AD85A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQ55</accession>
    <name>M2RQ55_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_134746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705359.1">
        <property type="nucleotide sequence ID" value="XM_007707169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUT6"/>
    <dbReference type="GeneID" id="19135428"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_261431"/>
    <dbReference type="HOGENOM" id="CLU_2542422_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="83" mass="9225" checksum="6C9B0B82E30695D4" modified="2013-05-01" version="1">MRHEQFDNSGQWQARSHRLRLTYLHPDHLTMVYPHHGQALDPSTAVFVFVALFSSLPPSSSLLFGSSSLSSSSLSWLQDSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXR5</accession>
    <name>M2RXR5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_246164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704165.1">
        <property type="nucleotide sequence ID" value="XM_007705975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXR5"/>
    <dbReference type="STRING" id="665912.M2RXR5"/>
    <dbReference type="GeneID" id="19135119"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_246164"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_172_1_1"/>
    <dbReference type="OMA" id="CSMGDLY"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="631" mass="70018" checksum="E1755A95313D2850" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2S276</accession>
    <name>M2S276_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_147910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD61323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S276"/>
    <dbReference type="STRING" id="665912.M2S276"/>
    <dbReference type="GeneID" id="19131430"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_147910"/>
    <dbReference type="eggNOG" id="KOG2909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017554_3_0_1"/>
    <dbReference type="OMA" id="VMIWIHV"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD61323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="393" mass="44090" checksum="B825D9742A4A3C4F" modified="2013-05-01" version="1">MSKGSKYLLVSLPTSISPSNHHDDALTALRSTVTNDVGNTSPFAIPNFKIGTLDALVQQADELSKLSNACEGVVAKVGESLRQILDGDESKVQQQKTINDKPVDQYLRSFQWNKVKYRADKPIADLIDALQKEIQGIDNDVKSKFSQYNQTKGALAAAERKRTGNLSTKSLVNVVNPKSIVRDSEYLDTHLIAVPNTAVKEFYQAYEELSPMVVPRSANKIAQDDEFTLFAVTTFKKHSNEFVHKCREKRWTPREYTYKEGGKEEEAKEADQLAKDERKLWGEALRLGRTGYSESAMIWIHVLALRVFVETVLRYGLPLDFVCGIVQTDAKSAKKAKANLDAAYSYLGGNAFGRDSKGRIKKDDQSMSIDMQQAGHMGDQEYTAYVYYEFEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2S2L2</accession>
    <name>M2S2L2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_39164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702583.1">
        <property type="nucleotide sequence ID" value="XM_007704393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S2L2"/>
    <dbReference type="STRING" id="665912.M2S2L2"/>
    <dbReference type="GeneID" id="19139431"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39164"/>
    <dbReference type="eggNOG" id="KOG2841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041616_1_1_1"/>
    <dbReference type="OMA" id="RIVLCMV"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="58"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD61433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="381" mass="41530" checksum="8E2C334C9F3F8A1E" modified="2013-05-01" version="1">MHDNRPRAHGSGPAPPANAHAAAQTSRPGAANPPAPSNVPKVQQPKPQALPSRSAPSSILVSPRQKGNPILNNVRAVAWEYSDIAPDYVVGATTCALFLSLKYHRLHPEYIYNRIRDLKGQYTLRILLTMVDIENHEDPLRELSKTSLVNNVTVMLCWSAQEAGRYLELFKTFENAAPTSIRAQQAGSYAENMVDFITVPRSINKTDAVGLVSNFGSIRTAINAAPEEIGLIAGWGDKKVQRWCNAVREPFRVQKAARRGGLVQEANNPPTVTEGEDQAQSAAVAGDTARQRVDDAVPLARELEKSAPFATSASDADKRSDHRLAEDINEDDEQAMRELEIGHVSGANEAQPAVATPAKRKQPDDNMSEGVMVALDKLRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2S5P2</accession>
    <name>M2S5P2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701610.1">
        <property type="nucleotide sequence ID" value="XM_007703420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S5P2"/>
    <dbReference type="GeneID" id="19139244"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38396"/>
    <dbReference type="eggNOG" id="ENOG502R8MW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1562607_0_0_1"/>
    <dbReference type="OMA" id="NPFSHKQ"/>
    <dbReference type="OrthoDB" id="4158258at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="172" mass="18493" checksum="FCD2BC843C9A7DC9" modified="2013-05-01" version="1">MTSAKSKASESGTSKNDTADTPPAYDGSSTSDPPPTYETVGHALTALSQGDPDEYITVPFVTRTVGFSIHNFNPFSHKQGEVRQSIVTRRMKRSQYLAHYVKDTNGNFVGTGRPAVDAALVFVPGKSSPEDLLRQFNEVALKVQRVRGDGIGEWGKPLQDNHTGHGGGGMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6X1</accession>
    <name>M2S6X1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_104759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445727">
        <property type="protein sequence ID" value="EMD58105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706193.1">
        <property type="nucleotide sequence ID" value="XM_007708003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S6X1"/>
    <dbReference type="GeneID" id="19129941"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104759"/>
    <dbReference type="HOGENOM" id="CLU_3147158_0_0_1"/>
    <dbReference type="OrthoDB" id="10375726at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="49" mass="5800" checksum="3C2665E29411049F" modified="2013-05-01" version="1" fragment="single">FNFKIIYYAETLNRVVDALSRRSNLREEGYKEPHNALLKIIPNSSLKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8I2</accession>
    <name>M2S8I2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease III homolog</fullName>
            <ecNumber evidence="15">3.2.2.-</ecNumber>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="15">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NTH1</name>
        <name evidence="18" type="ORF">COCSADRAFT_203977</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705365.1">
        <property type="nucleotide sequence ID" value="XM_007707175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8I2"/>
    <dbReference type="STRING" id="665912.M2S8I2"/>
    <dbReference type="GeneID" id="19134282"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_203977"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_4_1_1"/>
    <dbReference type="OMA" id="WGWHKTQ"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000027">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000014">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="17">
        <location>
            <begin position="181"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD58895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="419" mass="46381" checksum="B0E1AEF1ED4148A4" modified="2013-05-01" version="1">MRTSRISRDTSRILAASRAQRAQRQTRSAINASASTVDASHVKQEAQTDLASPSGPETSSAPADSYSDDEVQPAPKRRKKGQDASIAVKQEVEETSISTIPSPVKNAKVKKARRAPAKKTTASDGTVKIEPPANWEEIYALTREMRNENAAPVDTMGCESLADRSRTPRDQRFQTLIALMLSSQTKDTVTAPVIWGMQERMPGGFNLESVLALEPTELNGFINKVGFHNLKTKYIKQTAEILRDKWNSDIPDTIEGLVSLPGVGPKMAHLTMSAAWGRTEGIGVDVHVHRITNLWGWHKTQQPEQTRAALESWLPKEKWHDINNLLVGFGQTICLPVGRKCGDCKLADRGLCPSAVVAKRTKVKREEAVVKVEAPEGDAIVKKEIVEHVDEIKAEDVENVIPDIEDIGREPRKRTRRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8J3</accession>
    <name>M2S8J3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pcc1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_176147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705373.1">
        <property type="nucleotide sequence ID" value="XM_007707183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8J3"/>
    <dbReference type="GeneID" id="19133014"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_176147"/>
    <dbReference type="eggNOG" id="ENOG502SBSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113770_3_1_1"/>
    <dbReference type="OMA" id="VQYRATT"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13102" checksum="FED987ED1889E33F" modified="2013-05-01" version="1">MSSSKDWKQEDFPCTLTLHIPFPTAHLAQTAQLSLSVDTELSPLVRRAFTLTTPAGSTEQSVLQVDYAATTNRMLRVAVNGFVESASVVVGVMKELDTDVVHEPTKEELEGVQGLDVSKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8Q0</accession>
    <name>M2S8Q0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_330731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700737.1">
        <property type="nucleotide sequence ID" value="XM_007702547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8Q0"/>
    <dbReference type="GeneID" id="19137026"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_330731"/>
    <dbReference type="eggNOG" id="ENOG502SARD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096567_3_0_1"/>
    <dbReference type="OMA" id="CIRFLQF"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19581" checksum="A7CEE81AB7C400DE" modified="2013-05-01" version="1">MAFKFLSNSTLRGEKATMGTTLRSTFTPATILRLVLRLFQFVMGLTVIGMYAVDLDNARKQGKYVDSKWVWATLCGALGAFVSLLFMVPFLGRMVLLFAVDVVVFICYIVAFGIFGNMYIGEDAEGNKGVQRMKNGVWVLLTNVVLWFISAVLGAGLFWRARKARTTHTGRAPQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2S938</accession>
    <name>M2S938_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_172107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700854.1">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="F-box domain"/>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="310" mass="35333" checksum="84831D3F77FCF81F" modified="2013-05-01" version="1">MLSCRVQLDHGKHDCTYSPTATLGILYTFPIELQQRIVSHLDVKSLLVFRRVSKPAMSLVNSLLEYKKIMIHAPMALRMAIAIKTHHRFTISDLFAALCQRHCEDCGILAHYICLFTCRRICLSQEKYCEGSLAPCVTIPSSGGDYIITCGLFEYNSMIFRIPNNAPRFSPVPGFHMNARIAGKVDHFNKIDINSRDSYVDMNYVVPGLKKYLPESLRVVTEEKMVMMKSVSAVVAPWMSKRSLDAEYGMQCQTCMAEQKRYIARFRSNSNSSMRILQCAVWTKEELEKHMREEHGVVEKSVQGDLTESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M2S9I4</accession>
    <name>M2S9I4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_160249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD63998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699916.1">
        <property type="nucleotide sequence ID" value="XM_007701726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S9I4"/>
    <dbReference type="GeneID" id="19132025"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_160249"/>
    <dbReference type="eggNOG" id="ENOG502SJ1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008828_3_0_1"/>
    <dbReference type="OMA" id="YQHILAC"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="768" mass="85091" checksum="1A871AAEBBEEACC2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAZ1</accession>
    <name>M2SAZ1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_164531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704658.1">
        <property type="nucleotide sequence ID" value="XM_007706468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SAZ1"/>
    <dbReference type="STRING" id="665912.M2SAZ1"/>
    <dbReference type="GeneID" id="19132321"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164531"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622539_0_0_1"/>
    <dbReference type="OMA" id="TAYIKQM"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11395">
        <property type="entry name" value="bHLHzip_SREBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="328"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="441" mass="47934" checksum="F8281DFB77368515" modified="2013-05-01" version="1">MALNWDAFLNTDGFNLPNNQWSDSLPPTAAPRASQMPKSTTTDTSGSSPEDLNNFDSLIGASSADPYFDDSLFLSNDYFLGDLDVLKPFGNTAGGKSTTESSPEPTTSGNNPAAQAPVSLANGFDQSSYMSPAQRLALQRANTFPNPTYESMFPNNIDSGFVEDLTFPDGPKGLSVAAKPAVERNQSSTTTNTTSKRTKNKPDILSACWTSPLCPNHDQDGPPPNPSTCGGGCAPFLFADQDNLPSISDLLAEPQEVIAEDGIVEIQPRPKKRSESDASANGFSTRQFESKETTSSPTEDRHRTKSETTEDTSTKESPQADDGKPKSRRRLPHNQVERKYRESLNTQLDSLKRVVPSLQQNPRACDSADIEDLPAPSKPSKAVILASATAYIKQMEREKKSLADENQLLRTRVKALQALVKCDDCSLMQYVMDLKIKQGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB75</accession>
    <name>M2SB75_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_199919</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007702107.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SB75"/>
    <dbReference type="GeneID" id="19134117"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_199919"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="OMA" id="ARFDECT"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="282"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="84"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD64548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="716" mass="77841" checksum="C991A68824C08A18" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBP5</accession>
    <name>M2SBP5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_164089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704198.1">
        <property type="nucleotide sequence ID" value="XM_007706008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBP5"/>
    <dbReference type="GeneID" id="19132289"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164089"/>
    <dbReference type="eggNOG" id="ENOG502S764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107661_0_0_1"/>
    <dbReference type="OMA" id="YRRYQGN"/>
    <dbReference type="OrthoDB" id="2555434at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15397" checksum="5008A957D8DB0338" modified="2013-05-01" version="1">MFESRHAEDRYRLHLHRARSVVLTSDELVEIRAAQRTFEGAYVRTAIGQFSFALVVLKIFTAEFYSIGALFAVYGVGILFTSLFRRQQGNRQFFSEVGADGLCHKKFRTSGNIVVALTALSISAYICLLVLTLKLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2SC64</accession>
    <name>M2SC64_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_248267</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704304.1">
        <property type="nucleotide sequence ID" value="XM_007706114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SC64"/>
    <dbReference type="STRING" id="665912.M2SC64"/>
    <dbReference type="GeneID" id="19135157"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_248267"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="OMA" id="GATCAWQ"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025262" description="GOLD domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="28"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD60070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="220" mass="24994" checksum="E48190A6704B3089" modified="2013-05-01" version="1">MWKPTVLLAAALAVPAQALHFFLDGAVQKCFYEELPKDTLVVGHYHAEPWDDATKSYLPKSEVGVFVTVEETFDDNHRIVAQRGSAEGRFTFSAADSGQHRICVIPQNVQGGGGWLNQGIHGTVRFTLDMAIGETSRIESTDKDKVETLVQKVRDLNSRLLDVRREQVFQREREAEFRDQSEHTNSRVVRWSIIQLVVLGVTCVWQLSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCW9</accession>
    <name>M2SCW9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_36449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699170.1">
        <property type="nucleotide sequence ID" value="XM_007700980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCW9"/>
    <dbReference type="GeneID" id="19138733"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36449"/>
    <dbReference type="eggNOG" id="ENOG502RGRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_997502_0_0_1"/>
    <dbReference type="OMA" id="RNHNFAH"/>
    <dbReference type="OrthoDB" id="3860514at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31891" checksum="DE11A89D6B85A073" modified="2013-05-01" version="1">MTTTLPLRRSKRKQNEQAAALIPNTTKDIAPPPRKRARKANISPNTEPCIPKHEHAKVNQVITDTKPVRSQRYDTLPPFLALPRELRDEIYKHVLEQDESSTLKTGRGNNIVTRCGLVGVNNQISEEFLDAVLFHAHVITATVRNHNFAHVVTFLNRLSQAQLARLSTHGPTADEVDDDDRKPKRKIRIILSYSAGAKDSRVHLNRWLDRFDAPDKRGKEIEFEYHNDGTYRNGGYKQRPRLRGNASKRWNDEATKIGRGAARGRAWGGWGGYGGYVRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2SD39</accession>
    <name>M2SD39_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Ciuffetti L."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF5">
        <property type="entry name" value="ISOFLAVONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34075" checksum="ACAA9EFAC70DC552" modified="2013-05-01" version="1">MRIAIAGTCGLALLIAQEINNSTSHQLVILSRTHQTSLIASGYNCQTVDYNNAASLQHALMGVDTVISTVLGNPQLRLIEAAVQCRVRRFAPAEFQGQPGLRSQNGLLDRGEDSALALLKHYSGYIQHTVFVCGILYERFSVNGMMSHRIGASTGYGNEGDFIANPRQMTSIAPIYDAAQNPSWLCLTSAYDVAQFVVRAIDMPTWASEMSICGERMTVHSLVETIRACRNRAWVSIEYQAPANLEYHMTMAQLEDDVAGQRRLAPLLATAEGRYDFVVPAYLNTVFPNIHVTRFQDWFLRNWASIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFL9</accession>
    <name>M2SFL9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_35975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD66038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698441.1">
        <property type="nucleotide sequence ID" value="XM_007700251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFL9"/>
    <dbReference type="STRING" id="665912.M2SFL9"/>
    <dbReference type="GeneID" id="19138632"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35975"/>
    <dbReference type="eggNOG" id="ENOG502QUFU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057752_5_2_1"/>
    <dbReference type="OMA" id="THAKMYE"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="279" mass="31103" checksum="DB2F1701DECFDD4C" modified="2013-05-01" version="1">MASTSQQQVLDSLKSFLASGAYSDLSIKCGRDTYRVHKVIVCGRAGFFARAIKFGGQEAQTDQIDLPEDDPKTVKLLIQYLYEGEYDPVLPPTTPQTTTLAVVTPVKHWDTASKSLSFPHTCHMIEFRGFDGPSIYDCSNDQLCPHHRCSIDCRYRCREFSCQTCVLPNPIGPSSQLLTHAKMYELADKYEVVGLKELSKEKFSRGCKHFWDTPAFPIAARHAFSTTPGKDNGLRCCVSQAVATNMQLIRKPEVRALLMQFNGLALGILDAKSKELGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFQ3</accession>
    <name>M2SFQ3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_353052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699467.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFQ3"/>
    <dbReference type="GeneID" id="19138203"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_353052"/>
    <dbReference type="HOGENOM" id="CLU_2637908_0_0_1"/>
    <dbReference type="OrthoDB" id="10529557at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="77" mass="8595" checksum="C2D35C22FD0C4329" modified="2013-05-01" version="1" fragment="single">MPGKAKIMSFKDHKEAKARRATNEDAITKKEQRNRKCKDPPLQVPVGSRAVEGEVVNEALATTSTATPWRALIARMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHE7</accession>
    <name>M2SHE7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA ligase/cyclic nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_113234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698060.1">
        <property type="nucleotide sequence ID" value="XM_007699870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SHE7"/>
    <dbReference type="STRING" id="665912.M2SHE7"/>
    <dbReference type="GeneID" id="19130210"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_113234"/>
    <dbReference type="eggNOG" id="ENOG502RWX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051290_0_0_1"/>
    <dbReference type="OMA" id="FVDPRNC"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36507" checksum="AB2F5AB33F1200CF" modified="2013-05-01" version="1">MSSNVSAPANQANTFEDLSGISTSAFSNPYDALIAACEDDPARIQEKYQLHRTTRNSQQKAKMLQEDFPGVTIDPILLRKCDPTIEPGFEDPRNCFVFWGRPTHNVKDLIHRVQQELRTVAPNLWLMPRDNLHITALEVTHSKTAPEIQKLVDSVRDKIPAMTDYTYAHRARLIKPLIGYDASALALSFVPAAGEGLHDGRTLEDDKFTYHHLRRDMFSLCRDAGLNVDSRYVVPSSHLTIGRFIYSKDFENEQCASDPEKIKALVSKIEEINDWLQKEFWPEHNDGKIPDGGEFNLGQEKGLHCGIGTLWYGGGEAVHQGKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIP6</accession>
    <name>M2SIP6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_135669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696813.1">
        <property type="nucleotide sequence ID" value="XM_007698623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SIP6"/>
    <dbReference type="STRING" id="665912.M2SIP6"/>
    <dbReference type="GeneID" id="19130976"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_135669"/>
    <dbReference type="eggNOG" id="ENOG502SMBJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029564_1_0_1"/>
    <dbReference type="OMA" id="SWWPETR"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40829" checksum="7B72FA639F4C4C3A" modified="2013-05-01" version="1">MMPSWWPETRLEWIFSAAAATQGVVNTIIQMVILVVYLQWVNKPIYEVPLSYVISLILSINTLGCLYQLVLTLDAYRIKNHIQIFMLCVANVCLSVATILQYGEVHNASARAAVGVNGMNLPFVKRDWEFWRRVSPGLVVCAVVSCTCSTVMCFVAVKLYREFAWALYQDVSPDMTIQWKYMCYQIYLGFLKYTPYFVFAFILIYGLINVHYIEPEFSLTMAIIPATLLHLALAVYFVRHEIRICMILVLLFHVANIAYVISRLLVLYGHGLLSKTMMKDEMVFYLCIAGALSLFSLVAGSVCMFNFKKGLKHILLGQIKRRPQAHELEDDYYIQRLNYNIVPTPDRDSQRFLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJD7</accession>
    <name>M2SJD7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_342754</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701828.1">
        <property type="nucleotide sequence ID" value="XM_007703638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJD7"/>
    <dbReference type="STRING" id="665912.M2SJD7"/>
    <dbReference type="GeneID" id="19137561"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_342754"/>
    <dbReference type="eggNOG" id="KOG1440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023471_1_1_1"/>
    <dbReference type="OMA" id="FFAYMYF"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMD62465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="456" mass="52097" checksum="4B39F6077386CA9A" modified="2013-05-01" version="1">MARPRKDVKFQHQTRSASNGRARRPSQSLSEFSDPGSPTTIKEEAAPPVRWPAPEQPPQTEYEKKKANFITRTIWTLVMIAAFFWALGAGHLFIIIMVTAVQCISFKEVIAIANVPSKARSLRFTKSLNWYFLGTAMYFLYGESVIYYFKHILMVDRLLLPLATHHRFISFMLYIIGFIFFVFSLQKGHYKFQFTQFAWSHMALFLIVGQAHFVINNIFEGFIWFILPVSMVITNDIFAYLCGITFGRTPLIQISPKKTWEGFLGAWFFTVLWGIAVTHFVSQYKYFICPVNDLGANIWSGLECRPNPVFVARDYTIPFLPEGLPFPRTFNIMPVQFHVIMLGTFASLIAPFGGFFASGLKRTFKIKDFGDSIPGHGGMTDRMDCQFIMGSIAFFYYSSFIAVHHTTVGGVIESAITGLTYEEQMEVVKILSKHLVNQDIISPKVLELLSEQMVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SM84</accession>
    <name>M2SM84_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_79334</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695932.1">
        <property type="nucleotide sequence ID" value="XM_007697742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SM84"/>
    <dbReference type="STRING" id="665912.M2SM84"/>
    <dbReference type="GeneID" id="19140728"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_79334"/>
    <dbReference type="eggNOG" id="ENOG502QQI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_2_0_1"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="561" mass="62579" checksum="1C7AD688813D0DE8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMD5</accession>
    <name>M2SMD5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_41974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445657">
        <property type="protein sequence ID" value="EMD58306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705953.1">
        <property type="nucleotide sequence ID" value="XM_007707763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMD5"/>
    <dbReference type="GeneID" id="19140128"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41974"/>
    <dbReference type="eggNOG" id="KOG4062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_1"/>
    <dbReference type="OMA" id="DEAEWWF"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="161" mass="17881" checksum="7910260C5D6FF2CD" modified="2013-05-01" version="1">MAPGERSEEVWLWYTAVYEAIQEIPYGKVTSYGHIARLVGKPECPRQVGVCLKNLPSPSPSGDSSRTKPRFHSGNVPWQRVINAKGGISPRGPSAAAHQADALRREGVEVRQDGMGQYTVELDEYGWFPDMLPSEADQVEGSDMDEDKDEDEDEDEAAYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SME7</accession>
    <name>M2SME7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_51041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700498.1">
        <property type="nucleotide sequence ID" value="XM_007702308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SME7"/>
    <dbReference type="GeneID" id="19140278"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_51041"/>
    <dbReference type="eggNOG" id="ENOG502S9QG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039531_0_0_1"/>
    <dbReference type="OMA" id="SANVDCY"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF2">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3669" evidence="1">
        <location>
            <begin position="233"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="301" mass="34481" checksum="D400B9CC4C1A20AA" modified="2013-05-01" version="1" fragment="single">VGRGQCGTVLALNDTDWVIKIPNSPSKVDELFTDYQIHYSVYSALAPLTSVKISVPRPEAWITHGNTIWFVTAPCFPKGSPPIPNYGLISKRILSVPLCFREDIVDLLCPEAIKTEFLERHENKDCLVRLYLGRRSCTSHRESGNIRLRNFPLHVNEMKQLWLRPESYTITMAQTLAFLHWKAGIDANDIEFVLVGGHLVSSSYPSEQEVRAATKHTAGRLHVTNIRNQQTSMWLLDFNQCQHFEYHADGEAGCKEVMKKLAEGFWFNDPYYPRPNATDDEDKKLWDIFVEHYLKTSAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMS4</accession>
    <name>M2SMS4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_178287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696067.1">
        <property type="nucleotide sequence ID" value="XM_007697877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMS4"/>
    <dbReference type="GeneID" id="19133131"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_178287"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_6_1"/>
    <dbReference type="OMA" id="NESWISA"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="70"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD68468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="926" mass="102650" checksum="CCBB517AB58833C3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNW0</accession>
    <name>M2SNW0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_33735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3R)-atrochrysone 2-carbonyl-[ACP] + H2O = (3R)-atrochrysone 2-carboxylate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64236"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:20479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:234107"/>
            <dbReference type="ChEBI" id="CHEBI:234110"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:64237"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695614.1">
        <property type="nucleotide sequence ID" value="XM_007697424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNW0"/>
    <dbReference type="STRING" id="665912.M2SNW0"/>
    <dbReference type="GeneID" id="19137284"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33735"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_1_3_1"/>
    <dbReference type="OMA" id="GDHVMAW"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="277" mass="30639" checksum="6D627759F0350635" modified="2013-05-01" version="1">MVDALVPLPEIEKLSDRVIRVLGGNPGKFTLQGTNTYVVGRGASRLLIDTGEGRPQWIASIKSLLSKESIAIEKVLLTHWHHDHIQGVPDLLEHAPNTKVFKKDPHDDWLPIANGQKFETEGATLRAFFCPGHTTDHMAFVLEEEDAMFTADNVLGQGTAVFEDLATYMNSLDAMSKQFGGRAYPGHGPVIDNGPGKIKEYIGHRKQREQQVLDVLAADESRLGLSSMDVVKLIYKDYPESLWEPAERGILQILNKLKQEGKVTSGKTWSLSGKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP01</accession>
    <name>M2SP01_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_33786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695626.1">
        <property type="nucleotide sequence ID" value="XM_007697436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP01"/>
    <dbReference type="STRING" id="665912.M2SP01"/>
    <dbReference type="GeneID" id="19137304"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33786"/>
    <dbReference type="eggNOG" id="ENOG502QRFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_5_1"/>
    <dbReference type="OMA" id="KQHAGIN"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="511" mass="56775" checksum="785E4271B540ADEE" modified="2013-05-01" version="1">MPAMLDDPSAPVVYRTSGDIPYPPPGSPLPVGIAPYQVILRDRVTTATIIPFSAPNQVPLTLLAYLCDQLGREIEKGDTYPMVEPLPLESFGPYWFGVFGAIMLLGEIQDGRQLHEMARRGCDWERECLGSFYIKPNYPGRSSHVCNGGFLVTDASRNRGVGRLMGETYLDWAPKLGYTYSVFNLVYETNVASCRIWDALGFKRIGRVKGCGNLKSYPGELVDAIIYGRDLGQDDEFVSEERFDKIRFYLKNGKYPNGADRAEKSRLRSAATHYKLTPANDDEPEKLWLKGKEVIADPKQQYEIAQEIHHKQHGGINKTTAAIAELYHWVRIKETVSQVIRNCPECSEMNKGLSAMRQGQNQARAEARSASAFSTAQKTITPTPPTIFSPSQPPPPGPDSSSTQIPLASPQHSAHVYQQFAQQQQQQQQQQQQNTFDMPVDPALMQDVQPTGKLADLPPSPFLAAQPKGASRGGIGEDSRIRGDGMGLDDRAAMAGEEMRRRRLNRANGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQR3</accession>
    <name>M2SQR3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_176311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705508.1">
        <property type="nucleotide sequence ID" value="XM_007707318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQR3"/>
    <dbReference type="STRING" id="665912.M2SQR3"/>
    <dbReference type="ESTHER" id="cocsn-m2sqr3">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="19133022"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_176311"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OMA" id="EYGYDCP"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140214" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="21"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD59087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="535" mass="59436" checksum="60D38C696209ED81" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQZ6</accession>
    <name>M2SQZ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_152690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704970.1">
        <property type="nucleotide sequence ID" value="XM_007706780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQZ6"/>
    <dbReference type="STRING" id="665912.M2SQZ6"/>
    <dbReference type="GeneID" id="19131597"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_152690"/>
    <dbReference type="eggNOG" id="KOG2282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_6_1"/>
    <dbReference type="OMA" id="QAMAYGV"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ND90Pr / ATCC 201652</strain>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF02582"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRS1</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704464.1">
        <property type="nucleotide sequence ID" value="XM_007706274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRS1"/>
    <dbReference type="GeneID" id="19139811"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40698"/>
    <dbReference type="eggNOG" id="KOG3582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155992_0_0_1"/>
    <dbReference type="OMA" id="ACARQME"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057072">
        <property type="entry name" value="bHLH_INO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23181">
        <property type="entry name" value="bHLH_INO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="129" mass="14408" checksum="6F0F39B908EF50E4" modified="2013-05-01" version="1">MPASQSPTNAADRPRLTEAQKKENHIRSEQKRREAIREGFDRLASIVPGLEGQGRSEAVVLGGAIKLMREKIMERQQIINDAKAKGIDTTGWELDKDTMEACARQFERTMAEDRQAGNGDENGVDVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRT8</accession>
    <name>M2SRT8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_32595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694334.1">
        <property type="nucleotide sequence ID" value="XM_007696144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRT8"/>
    <dbReference type="STRING" id="665912.M2SRT8"/>
    <dbReference type="GeneID" id="19136837"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32595"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OMA" id="YGQVHAN"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="489" mass="52572" checksum="F7B9B2DB8412315B" modified="2013-05-01" version="1">MSTNPDSTISTTPNSLIPLWINNKPIYTTTVFPITPSSSTTPSHHACSASPKDATHAATASWTAFKSWRQTPHTTRRDLLLRVADHYSTHSATLVSTQTRETSCTPAWALQNVNLSISYLREIAAQISSVAGVIPPTEKPGTTGFVFKEPIGPVLCIAPWNAALILATRGIASAIAVGCTVVFKASEMCPATHFEITKAFLEAGVPGGVLNQVQCKREDAAAVTEALISHEAIRKVEFIGSAAVGRQIMAVAARYLKPVLMELGGKCPAIVLEDADLGVAAKQCALGATMNHGQICFSTERVIVLEAVAREFQERLIEAMGEVTREMTGAAVSEGIAKHARDLIQDAEAWGDTVVFPRLSDKDKEGGDGPTTVLPPALVLTPFSSSRIFDEETFGPSASLYVVKTDEEAIELANRSAYGLNATVWTRDMARFLKISRELEYGQVHANTISVYTSPTGSQGGVKNSGFGRMNGRWGLEEFVVEKFVTWCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS88</accession>
    <name>M2SS88_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_193439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD59951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="19133853"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193439"/>
    <dbReference type="eggNOG" id="ENOG502S025">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_0_1"/>
    <dbReference type="OMA" id="LVCLRIY"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="166"/>
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            <begin position="218"/>
            <end position="239"/>
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        <location>
            <begin position="44"/>
            <end position="283"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="386" mass="42346" checksum="12C2FF46EAFBAD7C" modified="2013-05-01" version="1">MMVNPSSPQWTPEQLAALQGEDGGPLIISIVSVFTAIGCILVCLRIYARSIIIRNIGLEDYCIILSFAHAIAMAVFQIEGAKHGGSKHMMFLTLPQIETTLKYLYGSILMYANALTLTKMSILLQYRRIFAFTSMRIPIYIVGAICLATGISASLVLVFSCIPVSAFWDISEKETAACINSNAFSFAGAAMNIVTDILVAALPVRAIWQLQVSRKQRIALMCILTLGWCVCIISIARLHGFIELAKHPEDSTFYGTAPAYWSSIEVNLGIVCACAPALKPLVVKVIPRFATLYGSRKSTYGGTKDTPKDSSSFVKLKGKGSIGTISDEVELHHRSGNVVSESYTGLPRTIHVKTDLEQQIDDFDRNVDTNSEKNLVIRPTRITDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST51</accession>
    <name>M2ST51_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_250575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
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    <dbReference type="STRING" id="665912.M2ST51"/>
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    <dbReference type="HOGENOM" id="CLU_573620_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="506" mass="57249" checksum="289F4A80E4C761D0" modified="2013-05-01" version="1">MFEKAKWPFLQPQFDDLRSNLRDAKGNLVLMIAVATLALAQRDGRQRPIHETERLELGSTIVQLEQARRIKPHEPTVHKVSKQPRGTTISSEENALESQSTNLMEASPPSPQQNIDPALVSSSRKHGVSSITKDVILARLPLKPPGNARLRDQGILDRSSPAAEVEANTLPKLLPDMRSITCPGSDLLHAQHSSERPFLQKSMASMPVSKSAGIIQIPKNRPQEKTASKNLTLTSSMSSTSDKTSYYQGWSTNYLQGLTTGNGDSITLNKMKLPERSLQKLVKTYFDEGHDPHIGMLELTKEQQDIIKRNCLDQSDAEIVYVHVQHNITISSVFGILNIETLNWIVDIKGSPQPTSPVVQNRMTYIPRPPTSIRRTSDMKTLFMKLVGARRKSVRRYPPPPDNDETRRFPEIPSEGFPNYDLQRTSNLYELIEPGRHKIHRPSIKYVPQRAEENDTKSSQKLLERRDTLEVPKFVHMRRKFIPTLPPAEENGEDIVRELLARWIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUH6</accession>
    <name>M2SUH6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_40093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUH6"/>
    <dbReference type="GeneID" id="19139644"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40093"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_293019_0_0_1"/>
    <dbReference type="OMA" id="PLHFSGE"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056485">
        <property type="entry name" value="ARM_KRIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24521">
        <property type="entry name" value="Ank_KRIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="KRIT1 ARM-repeats" evidence="4">
        <location>
            <begin position="420"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7593" evidence="3">
        <location>
            <begin position="886"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="815"/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="Manning V.A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="342" mass="38496" checksum="2F52286058AFCA6A" modified="2013-05-01" version="1">MFGFIADGLTAVTTVFFPIFASYKALHTSDPALLAPWLIYFVVLSACTAVENTFDFILSWVPFYSWIRFFAHLYLILPGAQGASYIYQEHLEPFLYHHEKEIDDFITQSHDRAKSAGMAYIEMGIEWVRVNLLGFAPRKPEAPPPAGQTYAQNLMSRFQMPAARGSNDLYGLVNQALSGASALYTAGTAETRDAQASELSRGAAKLVPDSIRNNEDRLNYVTSQRQRLESLLQAFDREQENIRTQQKGGNTHYESSRSSGSLSRNRSEAEFDRIERDELSSGSDRPPYPITPPALGRRTSSGWMPWNWQRQEASQDDPLAYGRDPGELRNRSRGSGFDLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVY1</accession>
    <name>M2SVY1_COCSN</name>
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        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
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    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_112846</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10249888at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA Polymerase II CTD phosphatase Fcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="156"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="519"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="669"/>
            <end position="787"/>
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    </feature>
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        <location>
            <begin position="627"/>
            <end position="642"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
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        <location>
            <begin position="735"/>
            <end position="751"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="803" mass="89919" checksum="E0304BF2ADADBE62" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWP9</accession>
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        <recommendedName>
            <fullName evidence="11">Abscisic acid G-protein coupled receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_240785</name>
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    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703548.1">
        <property type="nucleotide sequence ID" value="XM_007705358.1"/>
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    <dbReference type="STRING" id="665912.M2SWP9"/>
    <dbReference type="GeneID" id="19134997"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_240785"/>
    <dbReference type="eggNOG" id="KOG2417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039213_0_0_1"/>
    <dbReference type="OMA" id="FSVYCVY"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="203"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="334"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD61262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59274" checksum="7C433221FD0987AC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWR0</accession>
    <name>M2SWR0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_124907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703555.1">
        <property type="nucleotide sequence ID" value="XM_007705365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWR0"/>
    <dbReference type="STRING" id="665912.M2SWR0"/>
    <dbReference type="GeneID" id="19130609"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_124907"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1227327_0_0_1"/>
    <dbReference type="OMA" id="INYPDEN"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="226" mass="24895" checksum="D45D554A3CCC292E" modified="2013-05-01" version="1" fragment="single">MEARVNPTIQKIRGSTGLHIAVERMQEPTLIQLSGEHSADVKATNDDGTTLIHLAAANEHAPVLEYLLQNGANAETIYKNKRTPLIAAARHGKGFTHDLTIITRLLENNANPNLYSRKRGENPVQMAIRKDMGDVLESLVEKGANLSYQDIRGRGVLSYAIARNSIEILLCLCGQSIDVNNQDNARQTPLIFSTIGGIQVAVSRLIDSKAYLLLKDIRGRDALYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYY1</accession>
    <name>M2SYY1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_192177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702443.1">
        <property type="nucleotide sequence ID" value="XM_007704253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYY1"/>
    <dbReference type="STRING" id="665912.M2SYY1"/>
    <dbReference type="GeneID" id="19133792"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_192177"/>
    <dbReference type="eggNOG" id="ENOG502SA7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_776370_0_0_1"/>
    <dbReference type="OMA" id="GRVMNAK"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025477" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="213"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="351" mass="37044" checksum="343E93CC826B18DA" modified="2013-05-01" version="1">MMLFKRICLVALLAALASSSIIERATVDTLPLLTAISKDPELSTFYSLINSTGGTGGIPGPPFEERFNILADGRKYTAFAPINSAFEALQPGLAAALTAPASYVLLEAILRTHIAEGLVTTEEVRNSEKPVISIEGIPLKFASEGNTITINNQAKLVSAHGTTVGNGAIFKITSIIDPLVSIFGTDVNKNGSAIASARRRQAKKILEYELRPSGTIASVLSSLPDLSTYVDLLNATSPAFFNFLDSSLPAGKYISIFAPSNAALAAVGQGAKAIQPSNQPFTSYLLEYPFIDTTLVGSEKSIVGFPAAVRRDGDGAVTSVNNAAVKGEPKCMGNACVYVIDRWLDPVFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZE2</accession>
    <name>M2SZE2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ND90Pr</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701580.1">
        <property type="nucleotide sequence ID" value="XM_007703390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZE2"/>
    <dbReference type="GeneID" id="19139214"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38280"/>
    <dbReference type="eggNOG" id="ENOG502SJ1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013199_0_0_1"/>
    <dbReference type="OMA" id="YVQEMPP"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="719" mass="80959" checksum="8069952E6BA473B9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T092</accession>
    <name>M2T092_COCSN</name>
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        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_38383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701608.1">
        <property type="nucleotide sequence ID" value="XM_007703418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T092"/>
    <dbReference type="STRING" id="665912.M2T092"/>
    <dbReference type="GeneID" id="19139242"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38383"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_1_0_1"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD62452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="408" mass="43922" checksum="61D05E2CC519B733" modified="2013-05-01" version="1">MLSLRAIQRATPKLPAHSRTIHRSFASTARLDADFTHAVIGGGVVGLAIARKLQSRPSTSTVLIEKHGTAGTETSSRNSEVIHAGLYYGPSSRKTKLCIRGKTLLYDLCTQQGIPHRNTGKWIVAQDAEQMEALENVHDFAQNIGVPTRFLSKQEAATREPEVRAEAGVLESPSTGIIDSHSLMQYLEGDFENNGGICAFNSPVTRITPIDSGRSGWEITTTTAEETSTITAETLINAAGLYAIPLANTILPPSRQKTAFYAKGSYFSYSSSRPRTSTLIYPAPIPGHAGLGTHLTLDLSGRIRFGPDVEWTDSPSDYTPNTKNLAAAIADIKTYLPGVQADAIAPDYVGIRPKLGKLAATNGGKGFQDFYIEKEGGFEGWVNLLAIESPGLTSCLAIAEEVEGLLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0Q8</accession>
    <name>M2T0Q8_COCSN</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_57108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701110.1">
        <property type="nucleotide sequence ID" value="XM_007702920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0Q8"/>
    <dbReference type="STRING" id="665912.M2T0Q8"/>
    <dbReference type="GeneID" id="19140340"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_57108"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_5_1"/>
    <dbReference type="OMA" id="RYNCNIN"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="161" mass="16401" checksum="7A57C4B944453A46" modified="2013-05-01" version="1" fragment="single">TALQAAASSGNLELVQVLLNAGADVNAPPADNDGRTALQAAAYSGNLELVQVLLDAGADVNASAAKHAGATSLQAAALSGRVRVATTLLNAGADANAGGALENGRTALEGAAEHGRIDMVQLLLNAGVDLWRDGKVQYERTLQLASRNGHTVVKKLVEAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0X4</accession>
    <name>M2T0X4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_223018</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701977.1">
        <property type="nucleotide sequence ID" value="XM_007703787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0X4"/>
    <dbReference type="STRING" id="665912.M2T0X4"/>
    <dbReference type="GeneID" id="19134628"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_223018"/>
    <dbReference type="eggNOG" id="KOG0136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="OMA" id="NHGVHCF"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="306"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="517"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD62657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="699" mass="78730" checksum="A9428DDAE016B2A8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2T245</accession>
    <name>M2T245_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701086.1">
        <property type="nucleotide sequence ID" value="XM_007702896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T245"/>
    <dbReference type="STRING" id="665912.M2T245"/>
    <dbReference type="GeneID" id="19139180"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38140"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312157_0_0_1"/>
    <dbReference type="OMA" id="MERIAMI"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="144"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="969" mass="111707" checksum="FDD4E9B8D3D9621A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2T262</accession>
    <name>M2T262_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_145663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701484.1">
        <property type="nucleotide sequence ID" value="XM_007703294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T262"/>
    <dbReference type="STRING" id="665912.M2T262"/>
    <dbReference type="GeneID" id="19131352"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_145663"/>
    <dbReference type="eggNOG" id="KOG3484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140546_0_0_1"/>
    <dbReference type="OMA" id="RPINYGQ"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="117" mass="14077" checksum="360C215F54DFD1F0" modified="2013-05-01" version="1">MSGDLDIDFTRRNKKPRPLSEHEKEKLDEFVDAIHYSARYSDDVYEYRHVQLPKQMLKAIPKDYFDGARGTLKLLWEEEWRALGITQSLGWEHYEVHEPEPHILLFKRPINYQPPMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T296</accession>
    <name>M2T296_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_337987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701372.1">
        <property type="nucleotide sequence ID" value="XM_007703182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T296"/>
    <dbReference type="GeneID" id="19137311"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_337987"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="VMCQLTW"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF6">
        <property type="entry name" value="CYTOCHROME P450 2C30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="62424" checksum="679C54F6F52AF6BE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T420</accession>
    <name>M2T420_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_105358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694570.1">
        <property type="nucleotide sequence ID" value="XM_007696380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T420"/>
    <dbReference type="STRING" id="665912.M2T420"/>
    <dbReference type="GeneID" id="19129967"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_105358"/>
    <dbReference type="eggNOG" id="ENOG502S088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042166_0_0_1"/>
    <dbReference type="OMA" id="FEFQYLP"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="3">
        <location>
            <begin position="142"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="481" mass="55039" checksum="83DEEFF69DCA37A6" modified="2013-05-01" version="1">MALPNLFQRRTANTRYCWGYSFEWTPEHLTPEQMKPMKFSYDVLAEECLDRLNAISPPHKGALPRNDTTRTQMASTPGTEDEKKEPLPVPKRDLYALLEEHHESDPKLAELWRQVNTVPEWVDWEQIGRGQDVFYRYGGPALTGLTYQSLLGGMGAARVVETLARTGGFSTKVARGRLFETTQHILQCTRTLEGIQPGGEGFASSIRVRLLHAAVRQRIVKLVRERPSYFNVDEWGIPINDLDQIATIGTFSSTLIYLSFPRQGIILRQQEIDDYLALWRYIGYIMGTPDKWLSTPTRAKAIMESLLYYEVEPSDMSKVMANNIIYALKEEPPTFSSADMLTASARWLNGNALCDRLGLKRVSAYYWSLMAGQCLFFIFYCYTYRLFPNADRRRIERAKDIFWNLTVKSKWGLAGTETAFDFKYVPQYDTLTHLGDIGERKQQRFSNEMRNLKALGVAVGVLTVGTIVSVKTALHFVGRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4X3</accession>
    <name>M2T4X3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_36887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699813.1">
        <property type="nucleotide sequence ID" value="XM_007701623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4X3"/>
    <dbReference type="STRING" id="665912.M2T4X3"/>
    <dbReference type="GeneID" id="19138841"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36887"/>
    <dbReference type="eggNOG" id="ENOG502QS4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031603_4_1_1"/>
    <dbReference type="OMA" id="YFQLHDK"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013402322" description="mannan endo-1,4-beta-mannosidase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="30"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD64306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="375" mass="41600" checksum="DDB66A63245BBEFC" modified="2013-05-01" version="1">MKLLPTLFLSATAAALPASVDISAQASISKIDGLKFNIDGTTKYYAGTNSYWMPFLTNDTDVNISMSHLAASGTKILRVWGFNDVEGEPDSSSVYFQSFSGSTATINTGANGLQRLDAVVASASTYGIKLIIPFVNNWQDYGGMHAYFRACGVFINAQWYTKAECQAMYHAYIAAVISRYRDSPAIFAWELANEPRCRLCPTSILTNWIRQTSDYVRSLDPEHLITVGDEGFGLEGGAWFQYPYWYIEGIDWAANLALPNISFGTFHLYPEHWLVGGSFGDEWIRSHAEVCARIGKPCLLEEYGVSKREEQCAVEGAWQETSLGLREGGMAGDLFWQLGDTVVSTGNATHDDGFTVYYGSEEWKCLVDEHVESIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2T576</accession>
    <name>M2T576_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_160378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700008.1">
        <property type="nucleotide sequence ID" value="XM_007701818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T576"/>
    <dbReference type="GeneID" id="19132037"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_160378"/>
    <dbReference type="eggNOG" id="ENOG502T642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2903867_0_0_1"/>
    <dbReference type="OMA" id="NWQQEGH"/>
    <dbReference type="OrthoDB" id="3681095at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="62" mass="6951" checksum="65463C9087FA56C1" modified="2013-05-01" version="1">MSSSQNQQQPSSSGGRPTGATGGGYYRHPCRNWQQEGHPKNYNFIDQNDQLCAHCLCAPRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5P5</accession>
    <name>M2T5P5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_155905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694983.1">
        <property type="nucleotide sequence ID" value="XM_007696793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5P5"/>
    <dbReference type="STRING" id="665912.M2T5P5"/>
    <dbReference type="GeneID" id="19131723"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155905"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="OMA" id="ANYHVKK"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="247"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="740" mass="82063" checksum="203AA13D8FB65148" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2T686</accession>
    <name>M2T686_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_36116</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699100.1">
        <property type="nucleotide sequence ID" value="XM_007700910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T686"/>
    <dbReference type="STRING" id="665912.M2T686"/>
    <dbReference type="GeneID" id="19138663"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36116"/>
    <dbReference type="eggNOG" id="KOG2737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_1"/>
    <dbReference type="OMA" id="DAHALFF"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD64736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="463" mass="51940" checksum="EECACCBF963CF3BE" modified="2013-05-01" version="1">MAVAENYDEVLKGKYPAKEHAKKVKEWLVSKGGDKNGTIYLEAQKQKLNEDNDGEAPFRQRRYFFYLSGCELPDSYLKYEMATEKLTLYVPPVHPDEVIWSGLPMSPEEAKAKYDIDECFTTDELNSHLASTSESSQSTIYAIPEQVSDHVTFIAFKEKEFTQLKTAIEYCRVIKTDYEVALIRKANVISTAAHVAVMKAASKAQNECELEAVFLKACVERNAKNQAYHSIVAAGEHAATLHYVHNAAPITNQNLLLLDAGCELDCYASDITRTFPIKGTFTAESLAIYKIVLDMQLQCISALKSGVVWDHVHELAHKIAIKGLLDLGILKGDAEELFKKRISVAFFPHGLGHYLGMDTHDTGGNANYADKDVMFRYLRTRGALPERSVITVEPGIYFCKFIIEPYLKDEEKKKYIDESVLDKYWAVGGVRIEDNVLITKDGVDNLTPTPKDVDDITQLVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6B7</accession>
    <name>M2T6B7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_357538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700272.1">
        <property type="nucleotide sequence ID" value="XM_007702082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6B7"/>
    <dbReference type="STRING" id="665912.M2T6B7"/>
    <dbReference type="GeneID" id="19138508"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357538"/>
    <dbReference type="eggNOG" id="KOG4266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033653_0_0_1"/>
    <dbReference type="OMA" id="KSNANER"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026476" description="Peptidase S8/S53 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="42232" checksum="C8EE06DC82305480" modified="2013-05-01" version="1">MGWKSYLLPLLLEAVAGSKQQQVVPGAFIVEFQETGLEIQDLDYDLFKGAAVLFKNEKSPDEHMSLLLLNPAIKNVWPKTLLSTPNLQVGGVGSPGSTGSSHLVARDFQGNQTYSPHVMTKVDKLHAKGITGNGVKIAIVDSDVALDGCLGPDCLIVSGHDFVGDAYNGSTTLFLMMIQWIAWDMDGKIAAYKVAGCIGLIDNSVIAAGLLRAQQEGAHIITLFLIFSDGWNESFLDVIAARIVAKGVIVTVAARNSGDQGLFYISGPDGGNGVAAIASYENTTADDCGPISGNTADLSGKVVLISLGYIEEHLQSALDLGAHYIMISTKSNANERNFNLELSPGFLGVGVISHTLGTKWLAALATGKVVTLDFTGIATSLVTREQSPNNSTGGLLLRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6Y2</accession>
    <name>M2T6Y2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_170823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699524.1">
        <property type="nucleotide sequence ID" value="XM_007701334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6Y2"/>
    <dbReference type="STRING" id="665912.M2T6Y2"/>
    <dbReference type="GeneID" id="19132714"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_170823"/>
    <dbReference type="eggNOG" id="KOG2702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067202_1_1_1"/>
    <dbReference type="OMA" id="IYAPAFH"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03308">
        <property type="entry name" value="MeaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25790" checksum="CF4B3994E74F70ED" modified="2013-05-01" version="1">MTSDTRVDKLPVAILDLVKRTEKLLARQASNPSQRMLVALAGVPGAGKSTVSHALLIELAARGIKDIAIVPMDGFHYTREVLSTFADADVAFKRRGAPFTFDAEGCVRLVKSLKAAPVTADGEEDLCITAPTFDHAAKDPVENGIRISTRTRLIIVEGNYTLLKQKPWDEIAEICDERWFVDAPVEVVRDRLAQRHLAAGIESSKAAAIARAEENDIPNGELIRSLLIEPDVIIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7N4</accession>
    <name>M2T7N4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_36559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699193.1">
        <property type="nucleotide sequence ID" value="XM_007701003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7N4"/>
    <dbReference type="GeneID" id="19138756"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36559"/>
    <dbReference type="eggNOG" id="ENOG502RXQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_1_0_1"/>
    <dbReference type="OMA" id="SLKHFAH"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37056" checksum="F32F8BCAC8529407" modified="2013-05-01" version="1">MASKEYKFPAFDEAPKVEGMPQGNLWGFFDEDGKKDEVGTINLLTPAVVTRAAREEIRTGQSIQLDWELHNVQFPGFNRKPFAQKQIDFASFSALCANDDELHINTQAGSQWDSLKHFAHQATGTYYNGLTHAEAAKSDRNGTHKWCERGGIVGRGVLCDWLRWYEETKGKEAPSAVTRHEIPVEEVEEALRWQGTEVRQGDVLVVRTGYVRWHNNATEAERKSGTQDNNVAIGLQASERTVRWLYDRHLAAIAADNVAFEAWPSKLTDGWCLHEWLLVHWGTAIGEMWDLEKLSEKCKEEGRYSFFLTSAPLHVRGGIGSPPGAIAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7P2</accession>
    <name>M2T7P2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_36570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699198.1">
        <property type="nucleotide sequence ID" value="XM_007701008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7P2"/>
    <dbReference type="GeneID" id="19138761"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36570"/>
    <dbReference type="eggNOG" id="ENOG502SJYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100313_0_0_1"/>
    <dbReference type="OMA" id="CNLPWGT"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27329" checksum="BD2880B08518634F" modified="2013-05-01" version="1">MARHQHPIDGPADYPVADKREQTGLLTRFVPDRLKTTALYRWLLRLTRLLQFISSVVSLGIFSQRLYKVYRLVNSIKTRRGVNGAYGAVEGILAAAVLYTLLTVLLSCIKKSANPGGRKLRWLWVLLDLLFVGAFIAVAVLTRPNGGRAGAKHCYNPRRLIGVNSSSTITGETANRRDDSCNLPWGTFILAIISTFLHALTAAFHEIKDYRRSNRLDHEKNLQNQYATGQPGAPDGAPASSHTARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8D2</accession>
    <name>M2T8D2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_116751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699670.1">
        <property type="nucleotide sequence ID" value="XM_007701480.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2T8D2"/>
    <dbReference type="GeneID" id="19130336"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116751"/>
    <dbReference type="eggNOG" id="KOG1824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007157_0_0_1"/>
    <dbReference type="OMA" id="AYIPHFQ"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="1145"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD65207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1338" mass="145930" checksum="989EC713A809FD24" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">COCSADRAFT_197632</name>
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    <organism evidence="4 5">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697688.1">
        <property type="nucleotide sequence ID" value="XM_007699498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAA3"/>
    <dbReference type="STRING" id="665912.M2TAA3"/>
    <dbReference type="GeneID" id="19134026"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_197632"/>
    <dbReference type="eggNOG" id="ENOG502S675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="OMA" id="NLWGQAQ"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025764" evidence="3">
        <location>
            <begin position="23"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD66116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="245" mass="25936" checksum="78515B947751BC78" modified="2013-05-01" version="1">MKFSAFLAVSSASLALAVPASSIQKRADFCDQWGSQVNGAYTTYNNLWGKADATSGSQCTGVDGLSGNTLKWHTSWSWAGGQGKVKSFANVVTKINKKSLASIKSLPSVWKWTYTGNNIIADVAYDLFTSSTPTGSEEYEVMIWLAALGGAGPISATGRPIATVTLAGNSWKLYNGKNGQMNVFSFVAEKQVQGFSGDLMDFIKYLTSKQGLPSSQILISAGAGTEPFSGSNAKFVTSAFSLAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAD0</accession>
    <name>M2TAD0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_140222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698898.1">
        <property type="nucleotide sequence ID" value="XM_007700708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAD0"/>
    <dbReference type="GeneID" id="19131152"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_140222"/>
    <dbReference type="eggNOG" id="ENOG502QW3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015282_1_1_1"/>
    <dbReference type="OMA" id="TLQTYWN"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="725" mass="83605" checksum="488056360DC3DE5F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAK7</accession>
    <name>M2TAK7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="9">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_355348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="9"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698948.1">
        <property type="nucleotide sequence ID" value="XM_007700758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAK7"/>
    <dbReference type="STRING" id="665912.M2TAK7"/>
    <dbReference type="GeneID" id="19138359"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355348"/>
    <dbReference type="eggNOG" id="ENOG502QS3Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029332_3_0_1"/>
    <dbReference type="OMA" id="WNYPTRY"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23399">
        <property type="entry name" value="beta-trefoil_ABD_ABFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000131">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000059">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027164025" description="Alpha-L-arabinofuranosidase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="11">
        <location>
            <begin position="23"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="10">
        <location>
            <begin position="357"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="84"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD65932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="503" mass="52281" checksum="75D6E9D58F4BE331" modified="2013-05-01" version="1">MSSRSLLVALGLAATGSLVHAGPCDIYAKGNTPCIAAHATTRALYNAYSGPLYQVKRGSDGATTDIAPLSAGGVANAAAQDKFCANTTCLISIIYDQSGKGNHLTQAPPGAFKGPDVGGYDNLASAIGAPVSLNGKKAYGVFVSPGTGYRNNNVKGSAVKDQPQGIYAVLDGTHYNGGCCFDYGNAETNNLDTGNGHMETIYFGDNTVWGSGAGNGPWVMADLENGLFSGANPKKNTQNPSVSNRFLTTIVKGKPGVWAIRAGDATTGGLSTYYNGSRPSVSGYNPMSKEGAIILGIGGDNSNGAQGTFTEGAMTYGYPSDAIENEVQANLVAAGYSTGRGLMTSGPAYTVGSSVSLRATTAGYTDRYLAHSGATVNTQVVSSSSTALLKRQASWIVRAGFTNSECFAFESKDTAGSFLRHANFVMQVNANDGSKGFKEDATFCPQAGLTGKGSSIRTWAYPTRWIRHFNNVGYISSNGGVKEFDNASSFNDDITWLVESALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2TC23</accession>
    <name>M2TC23_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_301738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698146.1">
        <property type="nucleotide sequence ID" value="XM_007699956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TC23"/>
    <dbReference type="GeneID" id="19136190"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_301738"/>
    <dbReference type="HOGENOM" id="CLU_1669245_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="158" mass="17528" checksum="FF352807BFA5DC23" modified="2013-05-01" version="1">MMRTSSTFLQMEKCNPTSSFPNPSNQRHSQNPTITNYTITNYTITNLRNIPSVYSSTPTSAAHVEMLSKQSQSPQTTHTHTHARAHRSLRISLGPPTLSKQAACPLLGATLPSRHHVFEREASHMIPPMALVPERSVRLRGWGRGKSTNAAMCGLPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCC0</accession>
    <name>M2TCC0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_24909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697461.1">
        <property type="nucleotide sequence ID" value="XM_007699271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCC0"/>
    <dbReference type="GeneID" id="19135172"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_24909"/>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1855104_0_0_1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="138" mass="14974" checksum="377A773AAD0A336C" modified="2013-05-01" version="1">MSAYATVVLGAGIIGTETAFYLSNSPSHTSAICLVEAALEMFASASGKAGSLVAEDWFGPATTALGELSFRLHEELATEYEGRRNWGCSRSTGTIVVVGRGKQKKGKKRLEQGWNRAEPRSQQLRRSNITPRRKVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEK2</accession>
    <name>M2TEK2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_291486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697260.1">
        <property type="nucleotide sequence ID" value="XM_007699070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEK2"/>
    <dbReference type="GeneID" id="19136005"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_291486"/>
    <dbReference type="eggNOG" id="ENOG502SGW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048775_0_0_1"/>
    <dbReference type="OMA" id="TYMGVGF"/>
    <dbReference type="OrthoDB" id="5291209at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45586" checksum="3814660DA9DD4948" modified="2013-05-01" version="1">MKPGDYITRSAPPLLSTSTPSTPTHGRLKSSTLFWRVTGLIASLVLFTMYTNNTTMDTVDTEISPSNHSIFIPFIFEFSPKHVPQVMCTVEGVDIHMPVDTGSTGTLIGAPILLNIPSTAGTPAHHFFTSSKILYVGRMVELAMNFTGEGGSYATAKVPVLVVDKSWRCPWYNPLVDRFECPAGPHGEQAVERDTSQITYMGIGFGRNSLKDGMPFATPRVNPLLNLCTIDGESVKRGAMHAGYIVSREGVQVGLTPTAIREFAFTQLEPGLTWVEDSRDWAMASMCFSVNGEGRNCGSVLVDTGIAQMYIRAEKGVSMPTIVIPNPNPNGHAKVVKRVKPGTKITIGFPSLDQPAMSYSFTVGEKSAIEPNYVFPQLSNHSPYINTGRNLLFRYSIAFDAVGGRFGFRSVGNSATASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEV5</accession>
    <name>M2TEV5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF962-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_178975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698784.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19133171"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_178975"/>
    <dbReference type="eggNOG" id="KOG3292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081702_1_1_1"/>
    <dbReference type="OMA" id="ETHFAFY"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23473" checksum="1B14205974EE532B" modified="2013-05-01" version="1">MAIFDLKKNLVFYGAYHRDPTNVAIHMVCVPILLGTGFLFGTNTPTLPIRTHPLLTRLHLPPNLGTLAAATYSTLYLLLSPNLAGATITPIVLSLASASNYLTSRFSKTKVNSIAVAVHVVSWILQFVGHGKYEGRKPALLDNLVQALFLAPLFVWYEALFKLGFYKELKRKVEEGVEEEVGRMREGKKGKGKKKLLGEEGGEERGYGTVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFK6</accession>
    <name>M2TFK6_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">Peroxin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_111358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697160.1">
        <property type="nucleotide sequence ID" value="XM_007698970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFK6"/>
    <dbReference type="STRING" id="665912.M2TFK6"/>
    <dbReference type="GeneID" id="19130149"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_111358"/>
    <dbReference type="eggNOG" id="KOG4444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017002_3_0_1"/>
    <dbReference type="OMA" id="HRGWKDL"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="57781" checksum="D69AF61A0BD0FA4B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2THR8</accession>
    <name>M2THR8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_157163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696286.1">
        <property type="nucleotide sequence ID" value="XM_007698096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THR8"/>
    <dbReference type="STRING" id="665912.M2THR8"/>
    <dbReference type="GeneID" id="19131812"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157163"/>
    <dbReference type="eggNOG" id="ENOG502SA7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076645_1_0_1"/>
    <dbReference type="OMA" id="WSKLNKQ"/>
    <dbReference type="OrthoDB" id="10263401at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13376">
        <property type="entry name" value="OmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="232" mass="25353" checksum="A46327244EBB22D3" modified="2013-05-01" version="1">MTTQSQDSEFPTQAFATSADFNVFLDREHTTASGIFVKLAKKSSGIPSITAAEAVEVALCYGWIDGRANSIDDTWWKIRYTPRRAKSIWSKKNVGTVARLIEEGRMRPAGLAAVDAAKADGRWDRAYAGPATIVVPEGFKIALAKVPAAKTVWESMSKSEQFPTLLRIETGTQTGRSKRIDAVVQTLATGRRPGSSTTAKANRKTTPGKSDRVKKPSTDRGPRREGLRKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2TL68</accession>
    <name>M2TL68_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_32542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ND90Pr / ATCC 201652</strain>
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            <topology evidence="8">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
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            <end position="56"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="38"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_32578"/>
    <dbReference type="HOGENOM" id="CLU_1939219_0_0_1"/>
    <dbReference type="OMA" id="GGNNVQC"/>
    <dbReference type="OrthoDB" id="3497702at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026874" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69931.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="132" mass="13321" checksum="1777894760E48A41" modified="2013-05-01" version="1">MKASMIISSAALFCAGALAAPATARSASPVFTVQLANDISGKNANADVPVNGGARTFGQLFGGAFGPKVLATSIQAVSPGAGGNNVQCVLIDPAAPAFGVVLNSWNTFVDLDGNLDKAIETDVTTFTIECFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLG1</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_210825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694817.1">
        <property type="nucleotide sequence ID" value="XM_007696627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLG1"/>
    <dbReference type="GeneID" id="19134397"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_210825"/>
    <dbReference type="HOGENOM" id="CLU_1602551_0_0_1"/>
    <dbReference type="OrthoDB" id="3693278at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="166" mass="17646" checksum="C3D618BB3E426B51" modified="2013-05-01" version="1">MPSLARRPPLPHPLALALALALAFAFAFAFAFALMDQQKTIVTSLICMPVCYPTVGEMHCTLHRSYCGLSMVCPEPSVAMPSSLSMRSQPPFFFSSDSIISTLAPLLVTRPGIGSRGGYAKFCNLPMAAMLGAMRAVAAAESVGGPTADLRQSNSFPPPWPLTCTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2TMU3</accession>
    <name>M2TMU3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_132488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695181.1">
        <property type="nucleotide sequence ID" value="XM_007696991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TMU3"/>
    <dbReference type="GeneID" id="19130850"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_132488"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="QVENLEW"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD70032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="528" mass="59442" checksum="78AB5066EFE1BDFE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2TND9</accession>
    <name>M2TND9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_218157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695310.1">
        <property type="nucleotide sequence ID" value="XM_007697120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TND9"/>
    <dbReference type="GeneID" id="19134541"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_218157"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_4_1_1"/>
    <dbReference type="OMA" id="PNYKSIM"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026668" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="88"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD70197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="449" mass="48432" checksum="81B823519845AF9C" modified="2013-05-01" version="1">MRFTQSLTLALPAIAAAYPGMMGATSRADMEQHLRAQMESEIFAKRAAEPQLLKPVGNLLGSLGDLVDGLLTSVGQAVVKKSNKRPEPGFEFKLPGPNDSRGPCPGLNLLANHGYLPRDGYVSFGQVLEATARGFNMGVDLATVLATFAVLGSGDLDGLSFYLGSGKNGIGGLNRHSVVEADVSPNREDYYNGCGDNHHVSSRLVKQMVGFAAKDPKKEFSMNVMAEHYAQSASFSKNNNPFLYYFPFPQIVSLGAFAFYPQFFSNGTYGAGGVPNYKSIMSIIGAEYDTRTKEFKYIPERWPENWYRRDTPYGVVQAITDGFLAIYPRNIIVPGAAQVGTPNLSVQTLLCDVYQGLNSITPLALGGTEENVAKGVSWALSVLDPLLSKTALGCPDSVISPNFLFPGSQKEGGPANPPRVPSDRWTGNNVYGKVYFGGNKAPVEPMCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2TNH6</accession>
    <name>M2TNH6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_156362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695343.1">
        <property type="nucleotide sequence ID" value="XM_007697153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TNH6"/>
    <dbReference type="STRING" id="665912.M2TNH6"/>
    <dbReference type="GeneID" id="19131754"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156362"/>
    <dbReference type="eggNOG" id="ENOG502QW96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671167_0_0_1"/>
    <dbReference type="OMA" id="WNITEQE"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD70242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="333" mass="37615" checksum="F16EDEDE005AF072" modified="2013-05-01" version="1">MVGNGMLLGSAISLAKSLGLHRNPVPWNITEQEKTFRINVWYCLVIHDRWTSLTHGTPPHIRQTHHDVPLPKRTSPDEPGRIFEVLASLSTVLGTYLEGLYAISEGANIAALARNLLFDLNTWTDMLPGDIRRILVRGSDLNTPGTANLRLCYLALKFFNLRLDLSVEEADIPLGQASGERMVEARRSAEDIVLFVQELSMKQLGDFWLPTAAFVLSSTTTFFLRLAVQVDFPVFESPTQSLSLSLARELINSLRSHKELHGWELGDICLTQYADVVDRLWDQHVPTELDVTWLDSAPFISDPVFFHSIAPDQWGSLVWNEMFRGEQMEMNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2QUH6</accession>
    <name>M2QUH6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_153368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705295.1">
        <property type="nucleotide sequence ID" value="XM_007707105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QUH6"/>
    <dbReference type="STRING" id="665912.M2QUH6"/>
    <dbReference type="GeneID" id="19131621"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_153368"/>
    <dbReference type="eggNOG" id="KOG2441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006601_2_0_1"/>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="184"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
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    </feature>
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            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF02731"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD58794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="553" mass="62693" checksum="4C3A82E3BB9902DB" modified="2013-05-01" version="1"> </sequence>
</entry>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_44482"/>
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    <dbReference type="OrthoDB" id="194358at2759"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
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    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="80" mass="9533" checksum="2A6BE9034A6C7EB0" modified="2013-05-01" version="1" fragment="single">NRNKVQSTYNLFKALQTLVIRFLDSYLWNDMTCINQKDIKEVNVQVAIMAKIYAAAHRVIIWLEKSDEETERCLHLHRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
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        <name evidence="4" type="ORF">COCSADRAFT_100113</name>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
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    <dbReference type="eggNOG" id="KOG0893">
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    </dbReference>
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    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0022625">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PRK01192.1-1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD60044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14420" checksum="69A226D085466F5E" modified="2013-05-01" version="1">MAPTTKSAGKKSAGKTGRSAIADVVAREYTIHLHKRVHGVSFKKRAPRAVKEIRAFAKQAMGTNDVRLDPQLNKKVWESGIKGVPFRLRVRISRKRNDEEGAKEKLYSYVQAVNVKDPKGLHTQIVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2QYX0</accession>
    <name>M2QYX0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_250140</name>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704403.1">
        <property type="nucleotide sequence ID" value="XM_007706213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QYX0"/>
    <dbReference type="GeneID" id="19135198"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_250140"/>
    <dbReference type="eggNOG" id="ENOG502RU92">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477335_0_0_1"/>
    <dbReference type="OrthoDB" id="3790073at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="571" mass="64749" checksum="4FC214AC2B72BAD8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZ25</accession>
    <name>M2QZ25_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_240999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703672.1">
        <property type="nucleotide sequence ID" value="XM_007705482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZ25"/>
    <dbReference type="STRING" id="665912.M2QZ25"/>
    <dbReference type="GeneID" id="19135004"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_240999"/>
    <dbReference type="eggNOG" id="ENOG502S2A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_6_1_1"/>
    <dbReference type="OMA" id="MEGAMWD"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004023938" description="Amidohydrolase 3 domain-containing protein" evidence="1">
        <location>
            <begin position="42"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="99"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="680" mass="74035" checksum="4341CF44753289CA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2R627</accession>
    <name>M2R627_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_121436</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701931.1">
        <property type="nucleotide sequence ID" value="XM_007703741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R627"/>
    <dbReference type="GeneID" id="19130488"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_121436"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="OMA" id="QAWQGIF"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="159"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="368"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD62599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="524" mass="57713" checksum="A3D967C46ADD3921" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2R784</accession>
    <name>M2R784_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_37746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700978.1">
        <property type="nucleotide sequence ID" value="XM_007702788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R784"/>
    <dbReference type="GeneID" id="19139072"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37746"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_0_2_1"/>
    <dbReference type="OMA" id="DAPFFCD"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="286" mass="31593" checksum="555A4AA84E3A9626" modified="2013-05-01" version="1">MLPSQSASKIPPVKPDDRSFPRILCLHGGGVNAAIFEAQARCLIRHLQHSFRLVWVDAPFFCDPHPDVVDVYSSYSPFRRWLRWLPSHPELDEETCIEEIGYAMRTAMQDDDQAGGTGEWVGLMGFSQGAKLSASLLLEQQARENEAKKRGPAAPITPGPTGFPDIKWRFGVLLAGRAPLSNLNPKLLTSKTLVNAGRISEGFEFCKEVDEEATLRVPTLHVHGLADPGLELHRKLLNEYCEKGTATLVEWPGAHRIPIKSVDVDPVVAAIYDLAERVGVSVLRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2RA73</accession>
    <name>M2RA73_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_331598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700795.1">
        <property type="nucleotide sequence ID" value="XM_007702605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RA73"/>
    <dbReference type="GeneID" id="19137063"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_331598"/>
    <dbReference type="eggNOG" id="ENOG502SUZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111643_0_0_1"/>
    <dbReference type="OMA" id="IADACRC"/>
    <dbReference type="OrthoDB" id="3561297at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024243" evidence="1">
        <location>
            <begin position="17"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="215" mass="22589" checksum="1A99FB9819A34AA6" modified="2013-05-01" version="1">MLALKLILIAATSVLGVAIPEPTAAAQQAATCTKDNEILNALKKLGVPGTNFCREYINRPTTSTVTATITPTPVTTTSTAVVTVTSTQCGQQKRAAFLPPKHFQIETFDKGTRIKVDKRTNLPSQVARFPAAKIADACRCLCLKPKSPSTTATTTVTTFAPAPTVSVTTTATACVESQPPVCAAPGQPCNMDHPGKCCNLTCYVNRSSSVGPYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2RDB0</accession>
    <name>M2RDB0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_47038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699204.1">
        <property type="nucleotide sequence ID" value="XM_007701014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RDB0"/>
    <dbReference type="STRING" id="665912.M2RDB0"/>
    <dbReference type="GeneID" id="19140224"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_47038"/>
    <dbReference type="eggNOG" id="ENOG502T5FC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821515_0_0_1"/>
    <dbReference type="OMA" id="RGSHFFQ"/>
    <dbReference type="OrthoDB" id="5149635at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="289" mass="32425" checksum="8F270F788BED921B" modified="2013-05-01" version="1" fragment="single">MCDSTFTFGQRGSHFFQCPSAREYTRLPPKLSRLLQSTQLQTIHHLTLGFEDSFILTYRSTTGTSHVESSGPLPPDLLSFIHAPNRNVAQLRCYLGPYNSSFFTHDSSSYLWQNLPPALLSALEKNIKDGKWRDRPRIVVLGADASFALITEKNAAVWDLTCYPSLLSLLQEKKDTSRMGEVHSVTLHPYRYSSFLLHLKDGTLLSGNIPPHQVAGVNAMLEPLRKDSQENQALWMARRDSAKVDRPQRPSVLQQRAQLRREWGGRTSEVSVQGKGVKLSFSLSVSLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RDC7</accession>
    <name>M2RDC7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_315126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699389.1">
        <property type="nucleotide sequence ID" value="XM_007701199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RDC7"/>
    <dbReference type="STRING" id="665912.M2RDC7"/>
    <dbReference type="GeneID" id="19136448"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_315126"/>
    <dbReference type="eggNOG" id="ENOG502S8B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027006_1_0_1"/>
    <dbReference type="OMA" id="GVFAAPW"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="497" mass="53965" checksum="AB811BB46EFB5F73" modified="2013-05-01" version="1">MDTTFITIHDLSDDAHILYSSDSIVDILGHTPDEVVNRSVWQFFHPDELPLAKAQHSRGVRLDKAAVLSYCRLKNRQGEWVGCECCFSVVYDVLVCCTSVYRQGMQSQKRAVEAPIVRKLFASSPKDPRYHMLSHLSTKFDLGHEDQTHEPRAALFLNRFTRTLTVMYATSGIEQIIGISSEAMKGRSFYYCIAPNCLEDAVRCLESAKGNDSIAYMRFFFRDPRQDDSPEASSSESEDDIMTDVTSSDEESEGGVGLGTSGDASSRQPSVANNSTNESAEPSASRSNSREDPSYRSAASATHQAMFGGSALRSSISSASSPRSEPRDEPIELEAVISCTSDGLVVCLRRARPMLPGAMPVAQPAHQYNGIFAAPWATQPVFHPAPPQMPHYPLGARHPAMAHAGSSMDFQNSFMKSIRDVAVFAWALTGINGSLVDYARGKPVGESQPPDGFPIWNPLPDPNGFGGKQLSVAPSGYGSGSNSSASNDPFGFGDPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2RFS0</accession>
    <name>M2RFS0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_198537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698698.1">
        <property type="nucleotide sequence ID" value="XM_007700508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RFS0"/>
    <dbReference type="STRING" id="665912.M2RFS0"/>
    <dbReference type="GeneID" id="19134064"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_198537"/>
    <dbReference type="eggNOG" id="KOG1262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025883_0_0_1"/>
    <dbReference type="OMA" id="LWICPLR"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="502" mass="57206" checksum="32C3C057ECB09D4A" modified="2013-05-01" version="1">METHHATVASLAAQVAKFSASKTPFRIYHGSTLSTRTSSRARNQIIDVSSLDHVLQFDELEKTVLVEPNVPMDKLVEATMAKGFLPKVVMELPNITVGGGFAGTSGESSSYKYGLFDRTISGIEIILGNGEVVWASTEDHRDLFFTAAGSCGSLGVITLLKMELIQASNYVELEYIPVSSTEEALKQLRLHQDDYTVDYMDGIMYSLKSGVIMIGRLTDAPMDRMIQGFDQPADPWLYIHAEDIVKRTRGDKTTYRELIPTQSYLFRYDRGVFWSGLRAFKYFITPFNRVTRYLLDPFMYSRTMVHALHRSGLASRTIIQDYGVPYDAADEFIRWIDEKTGIWPLWLCPVKSAPLGERSFSQGNNIKDDILLNVGIWDMGPNDAQAFIKLNRDLEAKVTALGGMKCLYAHAYFTEQEFWEIYDEKKYMELRRKYHAESLPSVYEKVRVDLQGVVGDKSVRKRQSWSEWAYWQFWSTWPMGGLYGVASATKGLFFKSDFLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQK3</accession>
    <name>M2RQK3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_135094</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696354.1">
        <property type="nucleotide sequence ID" value="XM_007698164.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2RQK3"/>
    <dbReference type="GeneID" id="19130952"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_135094"/>
    <dbReference type="eggNOG" id="KOG0996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_4_1_1"/>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="795"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1099"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="516"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="674"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="948"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1119"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD68854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1473" mass="165158" checksum="22739956241BAADD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2RR35</accession>
    <name>M2RR35_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_31807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694113.1">
        <property type="nucleotide sequence ID" value="XM_007695923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RR35"/>
    <dbReference type="GeneID" id="19136529"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31807"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="OMA" id="IGISECA"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="347" mass="38431" checksum="2795660E8F1A2738" modified="2013-05-01" version="1">MAPPASLPTKPLGKTGRQVPALGFGMMGLSMAYGPTGNDEERLALLDRAWELGYTNWDTANSYADSEILIGKWFKLHPERRADIFLATKFGIKFAVDDKGEWNISADNSPEFFNECLEGSLQKMGVDYIDLFYVHRLDPKTPVEKTMELLANAKKDGKIKAIGISECASSTIRRAYTVAPVDAVQVEYNPFQLDIENETGTNLLSTCRELGITVFAYAPLGRGFLTGQIKSTDDFAPDDFRRVVPRFSPENFAKNLVLVDRFKALADKKGCTPGQLALAWLSAQGEDIIPIPGTKKVKYMEENVGALKVHLSKEEVQEIRDEVEKAEVAGHRNPPGAFTEYSVTVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRJ8</accession>
    <name>M2RRJ8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_166191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694592.1">
        <property type="nucleotide sequence ID" value="XM_007696402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RRJ8"/>
    <dbReference type="STRING" id="665912.M2RRJ8"/>
    <dbReference type="GeneID" id="19132433"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_166191"/>
    <dbReference type="HOGENOM" id="CLU_507127_0_0_1"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="537" mass="59170" checksum="B5D015ED190C8D07" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSZ6</accession>
    <name>M2RSZ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_185912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445657">
        <property type="protein sequence ID" value="EMD58348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706001.1">
        <property type="nucleotide sequence ID" value="XM_007707811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSZ6"/>
    <dbReference type="GeneID" id="19133529"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185912"/>
    <dbReference type="eggNOG" id="ENOG502R8GX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="OMA" id="IWSTCET"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD58348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="341" mass="38468" checksum="A86F6431AB346D7E" modified="2013-05-01" version="1">MARDDRSGEFIGVLGFFMCICILLVMLRCYCKLVIVKNFSADDYFSVLTLVSFLVFCTLARLGISNGTGKRRYLIPDENYPVGMKWWWACEPTYVITNIFLKSSIGIFLLRIAQRRTHRIILWTSLLSIQIYSVYFFFIFTFQCWPVSFFWEQFRGGKGYCIPSKVIVNSFYGYSALSCVTDWTFSIVPIFIVHGLQMNKRNKVTVGVVLACCAIGSSATIVRLPFINGLNDIPDFLYSTIDVAIWSTCETGIGLATSAAATLRPLLRQVLNDTSTHDSASRKRSRAWTSGHPSRAGYQEHPSQHGDHDIQLTSHSLKQYNVQVTGGDRSSPSSSTIRLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT13</accession>
    <name>M2RT13_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_195471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694947.1">
        <property type="nucleotide sequence ID" value="XM_007696757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT13"/>
    <dbReference type="STRING" id="665912.M2RT13"/>
    <dbReference type="GeneID" id="19133937"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_195471"/>
    <dbReference type="eggNOG" id="ENOG502R6WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012243_2_0_1"/>
    <dbReference type="OMA" id="TWAQANH"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011110001" description="pectinesterase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="157"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="384" mass="42148" checksum="8FEC4FE8020755EE" modified="2013-05-01" version="1">MRLVMIFAGILQVCAAIPAVNRKACQYPTQKPLDGCPKNTLLVGPGSNFSTIQSAVLSLPNDKNPYNILILPGNYTEQVNITRPGPVYLLGQTAHPETRTKNTVNILWHNATGAGLSTLDNAYTSVLTVAPTFNASLTGTGPTGFPVPPNTPFGNTDFRAYNLNFTNDYLPYSAGPSLAISVSYANTGFYYCAFHSYQDTLYIGKLGNAYIYDSEIAGQTDFLYGFGTAWIQSSLLTLRGCGGGITAWKGTNTTFENRYGVYIHDSELRKENATLAIKGKCALGRPWNALHRSIFADCEMDDSILPAGYIQWNAGDPRIGVNTTMAEYKNYGPGWDEAARRKSNVSVVMGEREYRAYKRVETVFQYPFSGEFGNTAWIDRNPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">COCSADRAFT_261694</name>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007707198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUX9"/>
    <dbReference type="GeneID" id="19135434"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_261694"/>
    <dbReference type="HOGENOM" id="CLU_1294293_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="213" mass="25583" checksum="617CE4CAECA2D683" modified="2013-05-01" version="1">MPLLITSIKSISSQPQHIPALAHFPAYPSVISDIFYPRIKRTEKTTLLHTAYPRIHNGIYLRPTQTHPRLTRRHTNVITAHSANRNIIYTFVQQAQLDKRLQHLIPRNARSQPRTPLFRPVRYQRFRSWHRTRRHRRIKLAARARAQEKRQQHRRIQRHTRRTTRRNRTPHRIQGSNNSRVRSSSRHAARKRMVDRVLGEVWKRRVGQQRECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUZ1</accession>
    <name>M2RUZ1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_261768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705393.1">
        <property type="nucleotide sequence ID" value="XM_007707203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUZ1"/>
    <dbReference type="GeneID" id="19135437"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_261768"/>
    <dbReference type="eggNOG" id="ENOG502SD8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090064_0_0_1"/>
    <dbReference type="OMA" id="WMGGESE"/>
    <dbReference type="OrthoDB" id="5411041at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="182" mass="21159" checksum="5A973961F4E43ECD" modified="2013-05-01" version="1">MATPNPIQNVPIPPEQRLALEQQQRYERIVRNLAIGGLVICPIIALLPPRKLDLYTFSLGIGFYLSADHLITLRTGRGLVQNLSPMRAMELPTDRARETQRILQEEREKGRKALERKEGQQKGVLGKLWMGDEDEGWKERRLEEERKALEEGKGYGDLIMEQIWDVWNWDKKKGKDNENKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2RV30</accession>
    <name>M2RV30_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_262218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705421.1">
        <property type="nucleotide sequence ID" value="XM_007707231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RV30"/>
    <dbReference type="GeneID" id="19135449"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_262218"/>
    <dbReference type="HOGENOM" id="CLU_1399321_0_0_1"/>
    <dbReference type="OrthoDB" id="3670187at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="195" mass="22234" checksum="0ADD4F1433C54ADE" modified="2013-05-01" version="1">MVRFNLITLLYMQLVNGCLVHLLLAIIPYIASSSQCAVCQLSRHDDQIRTKQGCTCVCLPVHMHFHYNSAAQHISLTRVWGKLEPYLQDVRRQRRAFSTMQATAFAKARVSHHRTTMLTCDRLSAHMQSPQLGPRCSASDSVQVRMAHPVSVVVLRNTRYVAHVYLRSLGRWIGIAMQSNWILADIQPHPPRHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2RVW6</accession>
    <name>M2RVW6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_102153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704980.1">
        <property type="nucleotide sequence ID" value="XM_007706790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RVW6"/>
    <dbReference type="GeneID" id="19129781"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102153"/>
    <dbReference type="eggNOG" id="KOG2174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134810_0_1_1"/>
    <dbReference type="OMA" id="ICARCAN"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13696" checksum="2125A04580A53ED4" modified="2013-05-01" version="1">MAGIKTIIGLSFVLAIGFLLVILSAALFHNYLTLLVVATYVIAPLPNWLCSRAANHDDFMESSGNGVVDFGRFLTGFFVVMGIALPTLLWHSAEIAGGAAAMSIFGGLLIYATIISFTLFFQEQEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RY31</accession>
    <name>M2RY31_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_100404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704238.1">
        <property type="nucleotide sequence ID" value="XM_007706048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RY31"/>
    <dbReference type="GeneID" id="19129694"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_100404"/>
    <dbReference type="HOGENOM" id="CLU_2928893_0_0_1"/>
    <dbReference type="OMA" id="QPLNIRY"/>
    <dbReference type="OrthoDB" id="3692205at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="61" mass="7110" checksum="B32490CD6BE57843" modified="2013-05-01" version="1" fragment="single">KKNIFLLYIPTHSSYLLQPLNVAYFSPLKRKYGDTILGLVRNRTNYISKKTFLPAFKAAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2S0E8</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_346105</name>
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    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S0E8"/>
    <dbReference type="GeneID" id="19137755"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_346105"/>
    <dbReference type="HOGENOM" id="CLU_2164322_0_0_1"/>
    <dbReference type="OrthoDB" id="10377003at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="111" mass="13563" checksum="08E4A14A79263C15" modified="2013-05-01" version="1" fragment="single">VINDRKELKALREYISIYIPLYIRTKLIKTLYKSLEYRHVCIDKIVRRLAKIFTIPRLRAKLMRELYKELSMRIYSIFYKKLLELVPLDTKLVIDIELKDDEYKVEKIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2S547</accession>
    <name>M2S547_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_219275</name>
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    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S547"/>
    <dbReference type="GeneID" id="19134557"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_219275"/>
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    <dbReference type="OMA" id="RDRVEIM"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="121"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="523" mass="57684" checksum="8A87BF87A64E0064" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2S5L4</accession>
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        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_94178</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703622.1"/>
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    <dbReference type="AlphaFoldDB" id="M2S5L4"/>
    <dbReference type="STRING" id="665912.M2S5L4"/>
    <dbReference type="GeneID" id="19141545"/>
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    <dbReference type="eggNOG" id="KOG2460">
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    <dbReference type="HOGENOM" id="CLU_018649_2_0_1"/>
    <dbReference type="OMA" id="NYDLISW"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
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        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
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    </dbReference>
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    </dbReference>
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            <end position="397"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD62443.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="624" mass="68636" checksum="08E23316687122E8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6K8</accession>
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            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_161346</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_161346"/>
    <dbReference type="eggNOG" id="ENOG502S0WX">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
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    <dbReference type="eggNOG" id="ENOG502S4RN">
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    <dbReference type="OMA" id="RVHCVEW"/>
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    <dbReference type="Proteomes" id="UP000016934">
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    </dbReference>
    <dbReference type="GO" id="GO:0070652">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR028163">
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    <dbReference type="PANTHER" id="PTHR16151">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16151:SF2">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </evidence>
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    <sequence length="398" mass="45110" checksum="4515307257B08838" modified="2013-05-01" version="1">MSRPLMLRRNFSLLNRVPHSHIVRSAARHGHDSIIIQRVRIRRPFFSNTRLVGTVAVTAAAYGLIQYLGLEIEVEEVQEQGRQDGWEVAGSEEDDEEEEDDDAILFIPTGFSRPRPRTFYKGSDTEWKTFKEIATDRARANKIRKELVSIVRNNAEKKTLYTSRLGKIDTSKGMSWVEIQFPNGPPVEYERPGIELTENLEWRKATRPVEDAHHRRLERVLYPKEATDALCKDTVRKAEKAWKTFKIYMGWDQESKSETVQELFQRISTNRQSTGGPTSIAPNSFSASANDTQQPGASPSPAPVDGPASIGLDLPDPKSMTLDLTQFRADFAKTYMPIVLQPPRGAFIVRALIEIYGDRARLTLNVSAVYDPKQGRYVQMSAVPWNYVEHYQSPKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7X1</accession>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701499.1">
        <property type="nucleotide sequence ID" value="XM_007703309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7X1"/>
    <dbReference type="STRING" id="665912.M2S7X1"/>
    <dbReference type="GeneID" id="19141459"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92657"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033293_1_0_1"/>
    <dbReference type="OMA" id="RIVIFNC"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3990:FF:000001">
        <property type="entry name" value="26S proteasome regulatory subunit S5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD63313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="298" mass="31458" checksum="C589393E224E88FB" modified="2013-05-01" version="1">MVLEASMIVVDNSEASRNGDYVPSRWEAQQDAVNMIFSAKTGANPESSVGLMSMGGNTPEILTTLTTDIGKVLDGLHRTKIKGSSHFVTGINVAALALKHRQNKSQKQRIVIFNCSPIEEEEKNLVKLAKKMKKSGISIDIIAFGELSDDTTRKLQAFSDNVQSAEGSYLATIPPSANLLSDSLITTPIVGGEGASNAGGEGGSGGGGGGASGGNDFEFGVDPSVDPELALALRMSFEEEKARQEKDKKAKEAAEGKSELEPVAEGDEKQPLLDDQGQPSGSGNKNKKDDDQDKMDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7Y2</accession>
    <name>M2S7Y2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_38200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701099.1">
        <property type="nucleotide sequence ID" value="XM_007702909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7Y2"/>
    <dbReference type="STRING" id="665912.M2S7Y2"/>
    <dbReference type="GeneID" id="19139193"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38200"/>
    <dbReference type="eggNOG" id="KOG0468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="127"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD63343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="993" mass="110998" checksum="B09F3F70D47717E1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2S845</accession>
    <name>M2S845_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_31437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705541.1">
        <property type="nucleotide sequence ID" value="XM_007707351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S845"/>
    <dbReference type="GeneID" id="19136434"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31437"/>
    <dbReference type="HOGENOM" id="CLU_1652017_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="160" mass="17004" checksum="31F22374F5AD13E7" modified="2013-05-01" version="1">MGRPGRLVTICSDCCVGWAMQRPKSDYCPALGRTLLLGAGVRWDLRDVGRRHVSEPSVRCSSSTVQLSRVPIPSTGLSGATWTTNRGNIRLHLAVTATTKGHRVGTLDICVRTVYPADASMIFRQCAPAKSILTAAAGGGQQQQQDGASTRHEGGSEGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2S8U0</accession>
    <name>M2S8U0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_37512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700440.1">
        <property type="nucleotide sequence ID" value="XM_007702250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S8U0"/>
    <dbReference type="STRING" id="665912.M2S8U0"/>
    <dbReference type="GeneID" id="19139000"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37512"/>
    <dbReference type="eggNOG" id="KOG2464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022500_0_0_1"/>
    <dbReference type="OMA" id="QDAGTDC"/>
    <dbReference type="OrthoDB" id="21018at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="523"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD63753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="708" mass="79261" checksum="D45D922F7727B354" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SA75</accession>
    <name>M2SA75_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_322551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="LaButti K."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Steffenson B.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="506" mass="57566" checksum="90BE02B49F44EED6" modified="2013-05-01" version="1">MVIMADFVQTFTHFNHAQRQQALTLLTAELTPYEWRYLHALTNSRSFQLDIIGRLPIELVAHIFTHLDPAAPYRFQIVSTRWRYILQSLPVLKAGLNSWYQGVANPSDFEHDTLCQRAARRIHRFRTGRPLGIYKITSDEQIACPSLLGDYLVWLSGTPQTSPMRVACIFNLQNWDLGHVAGEAREQLINLVLSDQIVVLVTAANMCYVYELPTLSQRKKFRVPSASYLQNVTCRRSTVACLASLDMHISVFIWDYNTQRGTSFTISHDSDMFLSTHGPRGLLHIAPLVQPESETIILMFVMDTPTETPNQTLFVCARYTFRGHCVSSFSPSLPELRPLLVWHGVTPFVPVDDSGNVFAARVNTTNPNSQPPNASIVSLLLRFDTKTNDLRVWEDPIHRSNSPRGINDYRASWWKDTWYGFHPSVETKNIITFMGTQDKAACIPISSDPYSEVTNVNIPTEPLFVHERYVVRVMSENIYLLCFHGSFVRPTMGCTSFMNGTIRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2SF17</accession>
    <name>M2SF17_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 21">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="6 21">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 21">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 21">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">COCSADRAFT_170316</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="21">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="6 21"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698910.1">
        <property type="nucleotide sequence ID" value="XM_007700720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SF17"/>
    <dbReference type="STRING" id="665912.M2SF17"/>
    <dbReference type="GeneID" id="19132691"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_170316"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
    <dbReference type="OMA" id="THALFCT"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="15 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 21" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="23">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMD65883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="514" mass="55654" checksum="E38F69FE8BF6C1DB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFM9</accession>
    <name>M2SFM9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_115406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFM9"/>
    <dbReference type="GeneID" id="19130280"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_115406"/>
    <dbReference type="HOGENOM" id="CLU_2474906_0_0_1"/>
    <dbReference type="OrthoDB" id="5369347at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="88" mass="9893" checksum="C9248058F4EB3A39" modified="2013-05-01" version="1" fragment="single">DSGSFTIETYRSSKSRTNGLLYSQFYSSIKEIFAAGNAYPFTNTAIETLALDPKLRKTWQHVGAGLSHDPVALVRAYLYTKLRCHYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SG76</accession>
    <name>M2SG76_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_137704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697797.1">
        <property type="nucleotide sequence ID" value="XM_007699607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SG76"/>
    <dbReference type="GeneID" id="19131061"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137704"/>
    <dbReference type="eggNOG" id="ENOG502RJY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012440_0_0_1"/>
    <dbReference type="OMA" id="HVQNADW"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD66263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="781" mass="89403" checksum="E5F3CB0E6F9CF794" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGJ7</accession>
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            <fullName evidence="4">laccase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="14" type="ORF">COCSADRAFT_83986</name>
    </gene>
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697868.1">
        <property type="nucleotide sequence ID" value="XM_007699678.1"/>
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    <dbReference type="AlphaFoldDB" id="M2SGJ7"/>
    <dbReference type="GeneID" id="19140981"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_83986"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="OMA" id="WTINGTS"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024987" description="laccase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="90"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="216"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="439"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD66353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="616" mass="66905" checksum="CA2AB81F4E6084D6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJD2</accession>
    <name>M2SJD2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_121144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701824.1">
        <property type="nucleotide sequence ID" value="XM_007703634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJD2"/>
    <dbReference type="STRING" id="665912.M2SJD2"/>
    <dbReference type="GeneID" id="19130477"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_121144"/>
    <dbReference type="eggNOG" id="KOG3153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_0_2_1"/>
    <dbReference type="OMA" id="HHLYMMT"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="182"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD62460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="261" mass="29357" checksum="7CCD8A046AB43341" modified="2013-05-01" version="1">MSHDRIKELFLARYLVEQELLDASFARPDLLILNQPITHFTAFEHLWKHSNYHVCADGGANRLFDMFAGELTQQREQFLPDIVHGDLDSLRNDVRDYYRDRGVSISRGGDQESTDFGKCMQKISSRVLSSGMRDILVLGTLGGRVDQGLGLLHEMIREETKHPNLRLWLFSESSLSLIIKAGITILRGVQASRVFTENVGLVPIYGPAVISTEGLEWDVKQWATRMGGQVSTSNHVKADSIRIETDAPILFTIETALLTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJP3</accession>
    <name>M2SJP3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_94081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
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                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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        <property type="nucleotide sequence ID" value="XM_007703065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SL09"/>
    <dbReference type="GeneID" id="19137228"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_336015"/>
    <dbReference type="HOGENOM" id="CLU_2133302_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="113" mass="12919" checksum="44FC49A91DF4E49E" modified="2013-05-01" version="1">MLYRLYFKRSVLLFVRVSFHARALRRVNGDLCVARVLNVVFGVSMWIGCAYKGGQKYKREVCVAIKCTWVSDVGITPFRLHVRGSPWICVLYDTPLDAGTLSLSLRSRPIFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SL83</accession>
    <name>M2SL83_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_336894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701299.1">
        <property type="nucleotide sequence ID" value="XM_007703109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SL83"/>
    <dbReference type="GeneID" id="19137263"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_336894"/>
    <dbReference type="eggNOG" id="ENOG502SQUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053359_1_3_1"/>
    <dbReference type="OMA" id="FNGQMIG"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="124"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="243" mass="26844" checksum="42772D6A39485509" modified="2013-05-01" version="1">MSDPPPSRAPSIPPLNLPSAALHIHSRAQDEQHPDSEAAVRHERQRVAKELEPVRRKRVATPSEANAENEPRDELSRHASTQADVPRETGDHNATTPCRTRFYDPVTKFWGTQISLSIEEGSLRDHLALERTFLGYLHTSLLLVVTGVVIAQLFRLQHSPHPHPHFGFYKIGKPLSAAFICMGIVVVLIGAIRFWRLQNALVRGKAIAAGWEVSLVMGLVGSLMLGTFGLVLGVDIDKMYFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMU7</accession>
    <name>M2SMU7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_279537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705921.1">
        <property type="nucleotide sequence ID" value="XM_007707731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMU7"/>
    <dbReference type="STRING" id="665912.M2SMU7"/>
    <dbReference type="GeneID" id="19135782"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_279537"/>
    <dbReference type="HOGENOM" id="CLU_2426870_0_0_1"/>
    <dbReference type="OMA" id="QRCNGAR"/>
    <dbReference type="OrthoDB" id="3688963at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD58476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="91" mass="9704" checksum="811AD30AFF682165" modified="2013-05-01" version="1">MSQSYAESLLSPSGSADDQIPASSTAIEIPSNSTSAGAQRKPRVALACKRCKRRKQRCDGARPVCRSCERAGVACAYERTLRPQYPGGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN45</accession>
    <name>M2SN45_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_104461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445664">
        <property type="protein sequence ID" value="EMD58202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706098.1">
        <property type="nucleotide sequence ID" value="XM_007707908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN45"/>
    <dbReference type="STRING" id="665912.M2SN45"/>
    <dbReference type="GeneID" id="19129911"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104461"/>
    <dbReference type="HOGENOM" id="CLU_013929_2_0_1"/>
    <dbReference type="OMA" id="ANAMECA"/>
    <dbReference type="OrthoDB" id="5425161at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="64"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="159" mass="18013" checksum="8FD11509DBC5B2F5" modified="2013-05-01" version="1">MLAQQPDALRQWFEQLQATIEQLGVQPDDMYNMDETGCRIGVASSQYVYSVGGRQVFVAHANNRELITLVECVCSTGFAIEPMVIIKAATIMEQWVVDLPDNYLIAISESGYSNDQLALAWLKHFDRRTKQRSTGAWRLLLVDGHGSHSTREFIEYAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN84</accession>
    <name>M2SN84_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_49288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705619.1">
        <property type="nucleotide sequence ID" value="XM_007707429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN84"/>
    <dbReference type="STRING" id="665912.M2SN84"/>
    <dbReference type="GeneID" id="19140253"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_49288"/>
    <dbReference type="eggNOG" id="ENOG502SKVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OMA" id="HCINANA"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="244" mass="27535" checksum="AFD2AF69B01B0E1D" modified="2013-05-01" version="1" fragment="single">AVSCVALRVYTRKFIIRSMGPEDWTMIVATLFTLVHLSEALVGALQFNMGFRASTMSLKQVGGNIRLIVAMLIGYSAIVTLIKISILLVYRRLAYNKRFEGFCKRTIIVLATYQVIFTIVAAAQCVPLHKLWDFTNTVPGFCININAFYHASSSFHILIDVWILTLPIQLIRRIPRKPREKLALYINLGLGVVSMVASIVRFRFLYIFTTSDDPIYGFVPVNTWSMVEVNVGILCATLPILRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPB7</accession>
    <name>M2SPB7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_31830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694123.1">
        <property type="nucleotide sequence ID" value="XM_007695933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPB7"/>
    <dbReference type="GeneID" id="19136542"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31830"/>
    <dbReference type="HOGENOM" id="CLU_2333490_0_0_1"/>
    <dbReference type="OrthoDB" id="10423647at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11163" checksum="31A67519206DE5A5" modified="2013-05-01" version="1">MGSDVGIRTRDVRGCEKIAGKEEFVWFLFVSGVCVYGCMGVWIMWITFCERDSSHTSIWRVVKRPTERTTTRGNMYMGVGRGPNLHFGIRSTLLPISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPX2</accession>
    <name>M2SPX2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_128373</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705308.1">
        <property type="nucleotide sequence ID" value="XM_007707118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPX2"/>
    <dbReference type="STRING" id="665912.M2SPX2"/>
    <dbReference type="GeneID" id="19130712"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_128373"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="OMA" id="IKGRSEM"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="210"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD58817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="384" mass="40721" checksum="E49929593133E700" modified="2013-05-01" version="1">MSADTVGKTITCKAAVAWEAGKDLSIEEIEVLPPRAHEVRIQIYYTGVCHTDAYTLSGKDPEGAFPIVLGHEGAGYVESVGEGVTNVKPGDHVVALYTPECKECKFCKSGKTNLCGKIRATQGKGVMPDGTSRFRCKGKDLLHFMGTSTFSQYTVVADISVVAITENAPMDRTCLLGCGITTGYGAATITAGRGGVEAGSNVAVFGAGCVGLSVIQGAAKNKAGMIIVVDVNDAKEEWAKKFGATHFVNPTKLGNQSIQEKLIEMTDGGCDYTFDCTGNVNVMRAALEACHKGWGESIIIGVAAAGQEISTRPFQLVTGRVWKGCAFGGVKGRSQLPGLVSDYLQGSLKVDEFITHRQPLDKINQAFGDMKAGDCIRCVVNMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR51</accession>
    <name>M2SR51_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_159782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699344.1">
        <property type="nucleotide sequence ID" value="XM_007701154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR51"/>
    <dbReference type="STRING" id="665912.M2SR51"/>
    <dbReference type="MEROPS" id="M28.022"/>
    <dbReference type="GeneID" id="19131985"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159782"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="OMA" id="GMLQQDM"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140216" description="Peptide hydrolase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="172"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD64770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="389" mass="43281" checksum="6528869947CA719A" modified="2013-05-01" version="1">MKSTTLLLPLYTAALAAAVSSPQDHQAVLQDQQQVTITEPDEYLIELSPGETRWVTENEKWELRKQNINFFDITHNKELGTLNRKVSAESVKFPEKPIHKKAIDPLLKELKKENMRAHLETFTSFHTRYYKSHYGAESSAWLLSQVNKTLVDAGAVNATVKPFPHPWGQSSIIATIPGKSDKTIVIGAHQDSINLYFPAFLAAPGADDDGSGTVTILEALRVLLQSPEILAGEAENTVEFHWYSAEEGGLLGSQAIFQSYERADRNVKAMLQQDMTGYVQKTLDAGEPESVGVITDFVDPGLTEFIKKIITTYCSIPYVLTKCGYACSDHASASKAGYPSAFVIESDFKYSDNKIHTTEDKIEYLSFDHMLQHARMTLALAYELAFASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSZ3</accession>
    <name>M2SSZ3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DFDF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_40382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704064.1">
        <property type="nucleotide sequence ID" value="XM_007705874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSZ3"/>
    <dbReference type="STRING" id="665912.M2SSZ3"/>
    <dbReference type="GeneID" id="19139719"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40382"/>
    <dbReference type="eggNOG" id="KOG1073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019221_4_0_1"/>
    <dbReference type="OMA" id="WYPPPGH"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="58972" checksum="90FE4E0D80196548" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST14</accession>
    <name>M2ST14_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_73280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698582.1">
        <property type="nucleotide sequence ID" value="XM_007700392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2ST14"/>
    <dbReference type="GeneID" id="19140502"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_73280"/>
    <dbReference type="eggNOG" id="ENOG502RIA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686943_0_0_1"/>
    <dbReference type="OMA" id="AWIASWS"/>
    <dbReference type="OrthoDB" id="5419508at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD65430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="389" mass="43809" checksum="8C25A489B8487B44" modified="2013-05-01" version="1" fragment="single">MSDTNPFPPFPPAVTLEEVQAATTSYPATYFNSHILKLSSYLIDITNTSTLFGKPANNPYTPSLNTLYLRLQNGQLPPSRLPASFQTPQHTQSPIHLRSDKPAAERPLADFEDLYYATLSLMQELHHLLTIRLQSGFNTLSDLACAGGPTLSSLQKSLTAYWSFFNDAACAKALDDAVREARVRAIREEIVRQVEVDELDIQDARCQLAGLYGEDVYAGVEGMWFVRDWAPAMVAVYLEGRWRGLLDAEKAENERMMAMVKSEKEGSEGQVATECQEAQSEMDVDTNQFPEQNHVERLSHDTNLRTEPQISQNQPFAHHTPVHHAQLHQVALHHQPLSAAIHTEHGPIYPADFDIMLEWQVRNQRVAQYTNYLRARASQDAQQAIQGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2STW7</accession>
    <name>M2STW7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_35762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698394.1">
        <property type="nucleotide sequence ID" value="XM_007700204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STW7"/>
    <dbReference type="STRING" id="665912.M2STW7"/>
    <dbReference type="GeneID" id="19138512"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35762"/>
    <dbReference type="eggNOG" id="KOG1380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_2_0_1"/>
    <dbReference type="OMA" id="TSAYGMY"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD65725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="502" mass="55412" checksum="48C30A2E8DEED7C0" modified="2013-05-01" version="1">MSFRPILPRPIAVRDTNSVCLRCWWRLAKAPLQSRQAFSSISSYRASAVTAGKDTNTFTKGYFQANPLLKDSFWTSKHQLQSSIVSIRSGNGQQSNKEHAAVTAEEVLPHRRRKKAKEQAMEDSETAYPIPHDASSKLANISSSLPNQSLKRLLTTYLSLSKPRLSFLVVLTATAAYSLYPVPGLLAPAATATPSLSTLTLFFLTSGTALCSASANALNMLMEPEHDAKMSRTRNRPLVRKLISPRGAIAFAIACGVFGTGALYYGVNPTTAFLGAANIVLYAGVYTPMKRMHVLNTWVGAVVGGIPPLMGWTAAANQYAHDGTWQELLFGEGSAGGWLCATLLYAWQFPHFNALSWSIRDEYRNAGYRMLAWVNPAMNGRVALRYAVLMFPICIGLSYSGVTDWSYVVTSSAVNGWMVLKAWQFWKAEGNKGTARGLFWASIWHLPIVMVLAMAQKKGLGERLYRSVFGYADIDEEDLYYEAGELEEERRQFAIVEGRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUD6</accession>
    <name>M2SUD6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_99372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703964.1">
        <property type="nucleotide sequence ID" value="XM_007705774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SUD6"/>
    <dbReference type="STRING" id="665912.M2SUD6"/>
    <dbReference type="GeneID" id="19141851"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_99372"/>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="OMA" id="YLNIFHT"/>
    <dbReference type="OrthoDB" id="3937513at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="66" mass="8170" checksum="F396FBE0229D5A7E" modified="2013-05-01" version="1" fragment="single">LYLDIFIIAYLNDILIYLENKEDYILYIKIVLKKLDKYSLRLKLKKYKFYKNKVNFLGYIIEVNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVE3</accession>
    <name>M2SVE3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
            <ecNumber evidence="7">2.3.1.38</ecNumber>
            <ecNumber evidence="8">2.3.1.39</ecNumber>
            <ecNumber evidence="4">2.3.1.86</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">COCSADRAFT_235908</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="32" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EC" id="2.3.1.38" evidence="7"/>
    <dbReference type="EC" id="2.3.1.39" evidence="8"/>
    <dbReference type="EC" id="2.3.1.86" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703182.1">
        <property type="nucleotide sequence ID" value="XM_007704992.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SVE3"/>
    <dbReference type="GeneID" id="19134874"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_235908"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_5_0_1"/>
    <dbReference type="OMA" id="HFMDNYG"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000169">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 28" id="KW-0520">NAD</keyword>
    <keyword evidence="13 28" id="KW-0521">NADP</keyword>
    <keyword evidence="14 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 28" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="30">
        <location>
            <begin position="1688"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="29">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="29">
        <location>
            <position position="1832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="EMD60787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2086" mass="232664" checksum="1899971ACE40F16B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVP9</accession>
    <name>M2SVP9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_124120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703280.1">
        <property type="nucleotide sequence ID" value="XM_007705090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVP9"/>
    <dbReference type="GeneID" id="19130584"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_124120"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="OMA" id="DTAFYYR"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026172" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD60912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="494" mass="53563" checksum="0354FCC4BD8C329E" modified="2013-05-01" version="1">MKACSTWFVALATLLSTTTLANPLDKRATLDECLASKGVPTYAKNTGNYTQAIKPFNLRVPITPASYAVPSTIKHIQDAVACGVAAGIRVSGKCGGHSYASFGLGGEDGHLVVDMRRFNNVTADPVAHTAVIGAGGRLGDIATKLYAQGKQAFSHGTCPGVGISGLTLHGGYGLSSRTHGLALDQVISMTVVLADSRVVTASATENPDLFWALRGAGGAFGIVVDYKFKTYNAPENIINFNYNFSPSNTSQLAHVLSTLQNFSLYDQPPELNMRTFVPGQLTGVYYGNRSSYDTIMNPLLAKIGASSTGSGATVSVKGWIDTLTAFAFGPLPQAEIYDTHENFYAKSLMTQPLSEKAIYALADYYFTTAVKIRRGWYLLIDLHGGKGSAVSAVPNSATAYSHRDAVFKMQFYDRIMNNDMYQTSYFSFLDGWVSAIEKATPGEQFGMYINYADPRLSKDEAHKRYWGENYARLVKLKADYDPKKVFEGPQLVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SW61</accession>
    <name>M2SW61_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_192990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703527.1">
        <property type="nucleotide sequence ID" value="XM_007705337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SW61"/>
    <dbReference type="STRING" id="665912.M2SW61"/>
    <dbReference type="GeneID" id="19133833"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_192990"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="OMA" id="NMYFGYT"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025412" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="42"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="408" mass="43282" checksum="89C038D09AD3EC98" modified="2013-05-01" version="1">MPDSKIVSRTLLAALALPAVSAELPPGAIAVPIVRDAGLAAYYAEFQVGTPPQKESLKVDTGSPRFSFLDSRNQECVLDPTACSTYGTFDNLTSSTCHYAGPGFFDALYASGNGDFLNDTLVLGGVTMPNMYFGYTSNYPSLGRVPKPIGTILGLSLECGSAGPDCMGKGPYLLPQLKNASLIDIMATSFYLGPDEFNVTNAQMIIGGAYDKAKVDGDMITLEMVDPFSNTLTGGQTNNVNVTALEVVLDGGNRTSQTFGESGVGVPVLIDTGVASWYVTETIFGAISHAFGITGTPPRGSQVVPVDCMYRDSNHSKGYISVVFGASGKIDVPLHEIVTLFADGKCGLFMTARQESIGIFGDPFIRAIYTIFDQENKTITMARVKHTTEQNIVPFPEGGFKVGSKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWG1</accession>
    <name>M2SWG1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_39051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702560.1">
        <property type="nucleotide sequence ID" value="XM_007704370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWG1"/>
    <dbReference type="STRING" id="665912.M2SWG1"/>
    <dbReference type="GeneID" id="19139408"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39051"/>
    <dbReference type="eggNOG" id="KOG4772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028449_2_0_1"/>
    <dbReference type="OMA" id="MYMRLRH"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="421" mass="47234" checksum="783495901620BB81" modified="2013-05-01" version="1">MADQDEDISHLRAPDATDYDPTEEAQDFRLLEKLTAQDSAHPTLPKRGEKDFESHETNLQLDTLEASRRAMHGVLSWQRTHTQKGHVLAMYDPERNMACVDKVKSQHFQTIGTNKGGKEWLLPEEALFLLERGTLDCRWPVKREIGDKTVYRTEDGAPMSLQSAYAAFIGFEGGVGGKLTLEMYNVYAGLKRSGYVIFRTGSWDHDRGEIVEAPPKPEQETTSSSNLITRFFSEIWRRLSQPTYTIPASNLAFGPLLKPGLFRSYTDIYRLLKLIPTHDRTAPPTFLLPSSAENPYRIHFDVYRTTSKFRKSARGPPDFRICVVDARTTPIPTGAQLNDLMAQVPEDPPKESDQPYQRLKHGCRNVVLAVVDNGIPSYIRVADSAFEDVKIYERAGPRGKGGRGRGGGRGRGRGGGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXE5</accession>
    <name>M2SXE5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_157432</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696758.1">
        <property type="nucleotide sequence ID" value="XM_007698568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXE5"/>
    <dbReference type="STRING" id="665912.M2SXE5"/>
    <dbReference type="GeneID" id="19131824"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157432"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="HDWFESR"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD66985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="405" mass="45596" checksum="6DC242BE9A0C40F0" modified="2013-05-01" version="1">MLNKLHGQPDSYDRKSRYRFGKTLGAGTYGIVREADCPEGKVAVKIILKKNVRGNEQMVYDELEMLQRMKHPHIVKFHDWFESRDKYYIVTQLATGGELFDRICEKGKFTEKDAAETIRQVLDAVNYLHQNNVVHRDLKPENLLYLTRDENSSLVLADFGIAKMLDSKTEVLTTMAGSFGYAAPEVMLKKGHGKPVDMWSMGVITYTLLCGYSPFRSENLADLIEECKNGRVIFHERYWKEVSPEAKEFIKNLLEPDPAKRPTSEAALRHVWLSGKTATDHNLVPEIKAYAAKARLRRGIELVKLANRIEALKMQEDEEEDVPGEADVPANAREAAGEAIAGHSDSKSLETKETPGTGKGPGRLSRIAKGAIFREVVLAKVREMKEQEARAEFEKNATSEKAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXM8</accession>
    <name>M2SXM8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_232790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702879.1">
        <property type="nucleotide sequence ID" value="XM_007704689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXM8"/>
    <dbReference type="STRING" id="665912.M2SXM8"/>
    <dbReference type="GeneID" id="19134814"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_232790"/>
    <dbReference type="eggNOG" id="ENOG502SJG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_0_0_1"/>
    <dbReference type="OMA" id="VGWEFDA"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="319" mass="36798" checksum="7940F0ACDD4AB2DB" modified="2013-05-01" version="1">MLPQSPQFGKLFNYFTLIALCMIGLIYQFHLIQDHLAARIPEIPAIIPCNPNGIPKLLWYKLGPKGLSEEARNWTDTCIKGNPEYRPHFMTDESGDEYVRKTFAFRPDIVNTYLAFPIPIYKADMLRYLLLWDQGGVWSDLDVSCKGVPMDEWVPPKYQGRASLVVGWEFDAGHDEPYMRQFCSWTFMAKPRLPYMMQVVDDILAEVRAKTLQYNVPVENITLEMMGDVVDFTGPRRLTTGTFRSLAKRLNRTLDITETYNILKPQLFEDILILPGHSFSALTNRYTPEEKLVLPPQLVTHHYSGSWKNDKGGEAKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY00</accession>
    <name>M2SY00_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_34057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696528.1">
        <property type="nucleotide sequence ID" value="XM_007698338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY00"/>
    <dbReference type="STRING" id="665912.M2SY00"/>
    <dbReference type="GeneID" id="19137423"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34057"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_2_1"/>
    <dbReference type="OMA" id="IQRRKEC"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="34"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="606"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD67200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="693" mass="77137" checksum="E7951C4836D3ADCB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY18</accession>
    <name>M2SY18_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_38648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702077.1">
        <property type="nucleotide sequence ID" value="XM_007703887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY18"/>
    <dbReference type="STRING" id="665912.M2SY18"/>
    <dbReference type="GeneID" id="19139304"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38648"/>
    <dbReference type="eggNOG" id="ENOG502RZMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_3_1_1"/>
    <dbReference type="OMA" id="KPWAKVD"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF4">
        <property type="entry name" value="7ALPHA-CEPHEM-METHOXYLASE P8 CHAIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33562" checksum="88F7D0072D4EC8FD" modified="2013-05-01" version="1">MTTARFSHIDTNSYTGKPWGKVDGPGTNFSQQWHERSVHNLRGREHEFNTDNSGFAVYQYPAKEKLFTDDAAVRDGYYSEVESLLREKLPGIKKVVIFDHTIRRRDKNSPRQPVQQVHVDQTPAAAEARVRRHLPAEEAEELLKGRYQIINVWRPIGHAASDHPLAVIDWRTTSPSDFVATDLLYPKRADLLDLDDRGKEKLPDPNNYTSTEGYEARGETLAVAPNDKHKFYYQKDMTPDEVMLLKCFDSFGEGMLSGKKGLSLRTPHTAFADPNTPADAPGRQSIEVRCLVFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY47</accession>
    <name>M2SY47_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_95971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="19141649"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000134_18_5_1"/>
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    <dbReference type="OrthoDB" id="4772757at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
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    </dbReference>
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    </feature>
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            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="122" mass="12839" checksum="DDDD02AF484F7C87" modified="2013-05-01" version="1">MASAEGHKTVVKLLLDKGADVNVGGRRDDTPLYAASAGGHEAVVKLLLDKGANINKRGRLYNTALYAASAKGYTAVVKLLLDRDADVNARGKHGDTPLYAAAAGGHEAVVELLRSKEQEQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_352203</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698813.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19138138"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352203"/>
    <dbReference type="HOGENOM" id="CLU_054809_0_0_1"/>
    <dbReference type="OMA" id="RTWRAKK"/>
    <dbReference type="OrthoDB" id="3695549at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="393" mass="43296" checksum="18E850ACED02C14B" modified="2013-05-01" version="1">MSPMPPDMLAYHINQNILPRPPSSRTPLQPVQINTSQTKETTTYLSPVHLRTSHTTGRNHFPIPQIQGVVPGFRRAHHSAQSSHSLSFPTPTTRDILQTINSTNSLPIPETTTQPPDLPKTQSSSYPRPSPPNFLHPFSIVPYTTLLSTTNYITATENAMSDSPHISLATILPLGLKLVFLGTLCAAALGFAWTVMVCCVVCFPQRREAELSVEEGAWRSSEVRRSSNNRTQHSIKPQPEKEGMRDVANNPFADLANTNGDSDRSGAVSSGLDIPATPRYRRQNNASLVSPRDPFLDPPVEEEEGGVRVERTEREWERARAEFFGEGIAGDEIEMRDLSGVQVEPVRKRNSGRSRIAAVVKRGFEMLDEGVGMVDGVVDDVVAAVARWTDDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0D5</accession>
    <name>M2T0D5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">COCSADRAFT_32982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697237.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19136988"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32982"/>
    <dbReference type="eggNOG" id="ENOG502RAJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="SHYEYAR"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD68020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="460" mass="50537" checksum="2F15DC63E98FD53C" modified="2013-05-01" version="1">MRIPLFRIWYSTTYTALLIILLLFLAVTPSDTIYQSIKSNEIQKLFVIGGVYVLTSLIVLLIYSTRIYTNRTVLAAIPKSYVPVEEGEVGKGVRRMIVKHFKRSAVVAWDSRPRDLRGEVEDGDEEKGQLSRAGTAESKKDKEKSHKKKGHHHHAADATIIPVSPKSPPWGHISHPGWASPSSPDLPNLQYWSVVCELPNLIEAKAVSLAPPDPALEESAQQYPDNAPPLPDARIVTLLQRPRAMGLREYLSRLAEFGLLNPPSLGPAFLSQYEYARFSTASLTETQFRDLMAIFAEVLNGMKEVDPAVIEEARALDVESDTRSLAPTESSLDSTISSHSHMPYRTPQLDRKSTLSSLNSFLSTSSSDASTSHSPQTARTAPSRQHERGSTIYGTPSQRSFAGSESETGSVVIHARSQRSPSTIFPNSSESSLGSQGSVIRLNLNPGEGELPYQYNIDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0F5</accession>
    <name>M2T0F5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_38543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701641.1">
        <property type="nucleotide sequence ID" value="XM_007703451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0F5"/>
    <dbReference type="STRING" id="665912.M2T0F5"/>
    <dbReference type="GeneID" id="19139275"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38543"/>
    <dbReference type="eggNOG" id="ENOG502SE7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002057_0_0_1"/>
    <dbReference type="OMA" id="FGGMCPF"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025492" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD62671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1128" mass="121153" checksum="72F14743E170BB59" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M2T172</accession>
    <name>M2T172_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_196252</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695930.1">
        <property type="nucleotide sequence ID" value="XM_007697740.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2T172"/>
    <dbReference type="GeneID" id="19133975"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_196252"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_0_4_1"/>
    <dbReference type="OMA" id="GHAMARY"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000012">
        <property type="entry name" value="DEAD/DEAH box DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
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                <person name="Han J."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="185"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="185" mass="18941" checksum="B104164398753B46" modified="2013-05-01" version="1">MSALSPSAPSQPTTSQAYTTPGNPTEKTPQEQSQATFNASDNAAFADQRIPTKQATHEQGLQNAKFEEGKGVHGAPAGEESKGLSEEDVGRHKELDEQQMAMPGEGRVADAVARKGVGLGGGGAQPGLESDLDRKKAEQAEAREAIKAEKAQAAAQGGALGQTGGPANPVDNATQGGGNYPNSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="4">DUF2406 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_161855</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701529.1">
        <property type="nucleotide sequence ID" value="XM_007703339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2B7"/>
    <dbReference type="GeneID" id="19132132"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_161855"/>
    <dbReference type="eggNOG" id="ENOG502RXHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037541_0_0_1"/>
    <dbReference type="OMA" id="RFPQDSY"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="356"/>
        </location>
    </feature>
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        <location>
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            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="204"/>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39432" checksum="6253AF05AE2DA37B" modified="2013-05-01" version="1">MENPTQKPRQRGLSFHSNKSRDPPAPKSPKSPSSKHERKFSEHLDPNSKADPNNAMNELQPIAAALEKPTLQSLRSFQHTDSSGNPIVDPDLSNPTRSRWERPLDTIRSFEAAIDGEYRRRSQSMRVDNTDHGSRRSSYYGGGYNDQSRHSNASYFPQRQYGRDSYADGHGYGGPVGGGPPPPRMRYGNRMQSDPGWTNRQSMQGVYPVNGYQKSRDTVHTNGSNGSHSDGPYSNDPSSENSSIERGVPVQPPQQDLSSQYAFINNFGRGPILEEFGERPGYEAPPPPPPQHNGMYSNGSPPQPPKHAMQPAPAPIKLDSGSAPASEQTRPKILSKNSSNAGEKRKSWLKKRFSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2J3</accession>
    <name>M2T2J3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_275665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68695.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2J3"/>
    <dbReference type="GeneID" id="19135703"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_275665"/>
    <dbReference type="HOGENOM" id="CLU_2145656_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="112" mass="12642" checksum="AB56742E41B4FC50" modified="2013-05-01" version="1">MVMTGMGKRVGIVVLSYGDRWFFWPVLGADFGNITASAWLVHGLKYHPFATSLHYYFAVVVTCVTYFTHNKEERDKEKSLCPIFLALRLQLAQITGRGKGADGVLIPHPHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2X8</accession>
    <name>M2T2X8_COCSN</name>
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        <recommendedName>
            <fullName evidence="10">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_118215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_142304</name>
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    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="FHYSNDI"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="214" mass="24656" checksum="22F1CC55B4CB325C" modified="2013-05-01" version="1">MDFSCIESHFRTPQLGFQVFHYSNDISNPHTLPLAYNIGVFDSLEQAQDAAQSELARVLKFHLNQGHSGRCFREMNLSLRGLITAYVDSLNKARQSIRRELILSEFHIVKFDAWDPSRAVHESNVQAHELSMYKLSSEIDPPFVQHDEERSPEWARSRIPLFVRRDEGPLRRPGDQPYTVRMGFLPPKPIPAIRSISEQSVKNSDSELLRRNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5A0</accession>
    <name>M2T5A0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_322034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700034.1">
        <property type="nucleotide sequence ID" value="XM_007701844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5A0"/>
    <dbReference type="GeneID" id="19136678"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_322034"/>
    <dbReference type="HOGENOM" id="CLU_1415037_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025641" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21666" checksum="9AB536EE179DA3A8" modified="2013-05-01" version="1">MKCRFFFSSFLPFIPTGLGTFGDSSRCFFRGEGRVSFPEGEFLSARKGIAVRHHNARYIPPIVLFCFPPMACPFFFSFFTISIVQSLLSLSFWENRKIDMRSVALISHNHYLLTQSHYGYCNLSYVMYLPHAINGQSIVTCLCVSTCVCVRVCAKDGEEMLGMRSTLRLMLEGHRIGPSPPSPPCLIIELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5U3</accession>
    <name>M2T5U3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_32481</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694303.1">
        <property type="nucleotide sequence ID" value="XM_007696113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5U3"/>
    <dbReference type="STRING" id="665912.M2T5U3"/>
    <dbReference type="GeneID" id="19136792"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32481"/>
    <dbReference type="eggNOG" id="ENOG502QPHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_3_2_1"/>
    <dbReference type="OMA" id="WGPINST"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026127" description="Glucanase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD69810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="456" mass="48321" checksum="39A3E69D14FCFFF8" modified="2013-05-01" version="1">MYRTLAFASLSLYGAARAQQVGTSTAENHPKLTWQTCTGTGGTNCSNKSGSVVLDSNWRWAHNVGGYTNCYTGNSWSTQYCADGDSCTKNCAIDGADYSGTYGITTSNNALSLKFVTKGSFSSNIGSRTYLMESDTKYQMFNLINKEFTFDVDVSKLPCGLNGALYFVEMAADGGIGKGNNKAGAKYGTGYCDSQCPHDIKFINGKANVEGWNPSAADPNGGAGKIGACCPEMDIWEANSISTAYTPHPCKGVGLQECSDAASCGDGSNRYDGRCDKDGCDFNSYRMGVKDFYGPGATLDTTKKMTVITQFLGSGSKLSEIKRFYVQNGKVYKNSQSAVAGVTGNSITESFCTAQKKAFGDTSSFATLGGLNEMGASLARGHVLVMSLWDDHAVNMLWLDSTYPTDADPSKPGAARGSCPTTSGKPEDVEKNSPDATVVFSNIKFGPIGSTFAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T657</accession>
    <name>M2T657_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_170543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_170543"/>
    <dbReference type="eggNOG" id="ENOG502RY46">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015101_1_0_1"/>
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    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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    <feature type="chain" id="PRO_5004026464" evidence="2">
        <location>
            <begin position="18"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="355" mass="39099" checksum="454E22EF2F2803A3" modified="2013-05-01" version="1">MLTEWLVRALFVNLAVASKTKPAPSNARFTTLVTFGDSYTDENRLGYFINNNGSAPPVGWQQPVGLKTASGGRSWARLASDYSGAKLYNYAVSGAVCSNQVSPRPLAAINAPFPDIDGYELPAFIADSKYVNPNGTKFFTGKASDTAYAIWIGTNDLGNGAFLTDKQLPGKTVIDYVDCIYDQITRLYNNGARYIVLLNLAPLELLPQYQLPEKGGLQSTQFFNDAPGKNLTALHGRMKNTVAALNRLFKYRTPYQFDHTELWDGATVVNFDVNALMQEIYYHPSEYLNGTAPPNVEGAAHLCNDQGSNCTTASSLDSFMWYDPLHPGEQTSRVIAREFLNVLGGESKYATYWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>M2T8B6_COCSN</name>
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            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_87743</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701465.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19141204"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_87743"/>
    <dbReference type="eggNOG" id="ENOG502T4H2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105487_0_0_1"/>
    <dbReference type="OMA" id="HACSATI"/>
    <dbReference type="OrthoDB" id="3694481at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025712" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="23844" checksum="AC112D54B1BF94D2" modified="2013-05-01" version="1">MQLITPFFLLIAGVTASPLIGINVGGLSVGVALSSPLINLSLETSKSSSAVATSTKGTTTTATTAPTITAASQPTMPSSFSAPVQGQGILTLDNLPAMPAVIDKSLSGVLGVVYGLLSGVCSTDYKCTITVAGSIQSLLVDGDKYAMNSTISAWCDQGRCYGSADIPLTATAPFIITCDHLTGGTSACSATISGAASAIFTNGRQTLELWGWITPAGYCKDGICVASITAVGDPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2TA04</accession>
    <name>M2TA04_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_140082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD65752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700621.1"/>
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    <dbReference type="STRING" id="665912.M2TA04"/>
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    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002663_0_0_1"/>
    <dbReference type="OMA" id="NTSKWSH"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="395"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="454"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
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        </location>
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            <begin position="1065"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
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        </location>
    </feature>
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        <location>
            <begin position="109"/>
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        </location>
    </feature>
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        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD65752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123438" checksum="92A9D8F38A86F8AA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">Cip1-like core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_114973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
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    </dbReference>
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    <dbReference type="GeneID" id="19130266"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_114973"/>
    <dbReference type="eggNOG" id="ENOG502SH79">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048955">
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        <property type="entry name" value="Polysacc_lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025806" description="Cip1-like core domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Cip1-like core" evidence="2">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="235" mass="25301" checksum="FF01B65D91D8C05E" modified="2013-05-01" version="1">MLRQTALFALALAAPAIAQVSEGFENGWDQTAWPSYAADCNQGGKVTLDTTTAHTGKNSIRVDGAGGYCGHIFVGTKKIPSGDVYVRTYLKASKAFTDSHVTFITMPDSAQGTNKHLRIGGQSKILMYNRETDDATLPDLSPNGIASSKPLPTNQWTCFEYHLGTDGSIETWLNNGTVSGLTVGNGASNPNGAQWSRSTIKPKITGVYFGWESYGGDTNTFWYDDIVVSNKRIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCD9</accession>
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        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_138996</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66871.1"/>
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        <property type="nucleotide sequence ID" value="XM_007700056.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19131110"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_138996"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_2_1"/>
    <dbReference type="OMA" id="RCDVRNW"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31036" checksum="E82C316BB01B12A3" modified="2013-05-01" version="1">MASIDQPLNNGILLVTGGASGIGFGVVKQAYELGARVLVADLKTTPDFDSFAASKDNIVYVQADVTRWSDFDNLFDVCEKKWNDVPDAYAICAGLFEPEFSNFWKDPEKDEGYMQVGVNVNHPIKLTRLAIRKSLGKGKRASVCIIASLAGIGGNLAAPLYCATKHAIIGFVKSLATSEPLTGVKITALCPGAVLTPMFDATKMKQFSLIPDAALTPDTCAKHLLELLQKKEYPCGSMLELTLAGTGLIPEWGIEQPAGMGTGQEVDEVSVNNLMQPLKDVLDVEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TCL8</accession>
    <name>M2TCL8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_168221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696738.1">
        <property type="nucleotide sequence ID" value="XM_007698548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TCL8"/>
    <dbReference type="STRING" id="665912.M2TCL8"/>
    <dbReference type="GeneID" id="19132561"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_168221"/>
    <dbReference type="eggNOG" id="KOG1565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711734_0_0_1"/>
    <dbReference type="OMA" id="DDKMGIH"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF323">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD66961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="320" mass="35467" checksum="B1768BF16D44D354" modified="2013-05-01" version="1">MNSAPLNIVQAASNVKADINIRFLPINSNRTVAITTIDSDGVYFTPGKINITFNDNEQWTDDILFSTTAVHEIGHALGLSHSTIPSAIMFAYYDGLMHPIHPDDKMGIHSIYGWKTPKWKLIDSGSKVSSMIQVTSSFNTPAPNDGLYQMRPTGQILRYINNAWTTVDNYKETAQITGANGILYQRHYDGGTFRWTGTDSNWQSISPTDTSILDIHAASDQLYARRKDGSVVRLSGSTWLTIDQTAPGSRQIAVSYDKTLWNMLANGDLVRSRWPYTSAAILDRNAANIGIAVGGNEFFKVQSDGAVVWLDNKGPYWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDJ4</accession>
    <name>M2TDJ4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_34139</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696552.1">
        <property type="nucleotide sequence ID" value="XM_007698362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDJ4"/>
    <dbReference type="STRING" id="665912.M2TDJ4"/>
    <dbReference type="GeneID" id="19137476"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34139"/>
    <dbReference type="eggNOG" id="KOG4077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099086_0_0_1"/>
    <dbReference type="OMA" id="MEKWPAD"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD67311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="146" mass="16738" checksum="AA3C3B2B0D58E47E" modified="2013-05-01" version="1">MLFMRAASKVSRVAVPAYRAPTVALNAQRTFSQSAIRKSDAHAEETFEEFTARYEKEFEKVNDVFELQRNLNNCFAYDLVPSPAVITAALRAARRVNDFPSAVRVFEGIKFKVENKGQYAEYLQELEPIREELGIPLKETLYPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFL9</accession>
    <name>M2TFL9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_167314</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695759.1">
        <property type="nucleotide sequence ID" value="XM_007697569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFL9"/>
    <dbReference type="STRING" id="665912.M2TFL9"/>
    <dbReference type="GeneID" id="19132505"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167314"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_1"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="17">
        <location>
            <begin position="390"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD68046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="507" mass="55674" checksum="B95B7B50A17177BC" modified="2013-05-01" version="1">MLARHAPAQKALSAATHRALPAASAATRLSTAAPSNRTQKRTLATVQDTPPKRTYGGLKDQDRIFQNLYGHHGADLKSAMKYGDWYKTKEILLKGHDWIISEIKASGLRGRGGAGFPSGLKWSFMNFKDWDKDDKPRYLVVNADEGEPGTCKDREIMRKDPHKLIEGCLVAGRAMNATAAYIYIRGEFYHEATVLQRAIQEAYQAGLIGKNACGSGYDFDVYIHRGMGAYVCGEETSLIESLEGKPGKPRLKPPFPAAVGLFGCPSTVANVETIAVAPTICRRGGSWFAGFGRERNQGTKLFAISGHVNHPCTVEEEMSIPLRELIEKHCGGVRGGWDNLKAVIPGGSSTPILPKHICDDQLMDFDALKDSQSGFGTAAVIVMDKSTDVVRAITRLAKFYHHESCGQCTPCREGSKWTHQIMDRFYKGQAREREIDMLQELTKQVEGHTICALGEAFAWPLQGLIRHFRPELEARIKDYGLKHGGEALAGGWAHDAAKKGQLIAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFY4</accession>
    <name>M2TFY4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_81712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697247.1">
        <property type="nucleotide sequence ID" value="XM_007699057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFY4"/>
    <dbReference type="STRING" id="665912.M2TFY4"/>
    <dbReference type="GeneID" id="19140850"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_81712"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_6_1_1"/>
    <dbReference type="OMA" id="CNENYQV"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000002">
        <property type="entry name" value="Cora family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD67642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="654" mass="73731" checksum="88D7EAF8B8501F61" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2TH10</accession>
    <name>M2TH10_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_196018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695737.1">
        <property type="nucleotide sequence ID" value="XM_007697547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TH10"/>
    <dbReference type="STRING" id="665912.M2TH10"/>
    <dbReference type="GeneID" id="19133964"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_196018"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007105_4_0_1"/>
    <dbReference type="OMA" id="SYFVRWV"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000013">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="216"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD68012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1000" mass="108822" checksum="AB777B92C7C01C4C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2THA6</accession>
    <name>M2THA6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_79220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696164.1">
        <property type="nucleotide sequence ID" value="XM_007697974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THA6"/>
    <dbReference type="STRING" id="665912.M2THA6"/>
    <dbReference type="GeneID" id="19140720"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_79220"/>
    <dbReference type="eggNOG" id="KOG1604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_3_0_1"/>
    <dbReference type="OMA" id="IYHHISR"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000015">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36924" checksum="E3EE0F2DCA25DD8A" modified="2013-05-01" version="1">MSSKAFTFLPLGAIIQKFHVNGKNIVQGFPSAELYKQYNAPFFGETIGRIANRVSKAKINDLNGKSYQLPLNDGSNSLHGGHMGWGKREFEGPTTVDRNGKEATLFKYLSKDGEEGYPGTVQVSVWYVQEKEKVDGVQQEVLHIEYEAELVGDEVDETAINMTNHSYFNLTEGPSIAGTEVTLITNKYQVVDDGGIPTGPIEEYPGVSPQKTFTLGEKEPDIDDCFVVNTDPSSVPIDTRSLALQKLASFYHPESKIHLEVHSTEPAFQFYTGKYIDVPAVGDLPARRARSGFCVEPSRYVNAINIPEYKPMMVLKKGQKYGTKIVYRGWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2THK1</accession>
    <name>M2THK1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_269895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695861.1">
        <property type="nucleotide sequence ID" value="XM_007697671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THK1"/>
    <dbReference type="STRING" id="665912.M2THK1"/>
    <dbReference type="GeneID" id="19135594"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_269895"/>
    <dbReference type="eggNOG" id="ENOG502S112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627215_0_0_1"/>
    <dbReference type="OMA" id="ENNSGME"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="361"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="430" mass="44165" checksum="C8C0668A902CDE0E" modified="2013-05-01" version="1">MAADKKLAKKSSSDKKQNKTSAVAASTTTAAEAPLDLVRKFLEQQGEKGAASKLNEFEKWQKSGGATNSPDAPEPMDVDEESASSSDSSSGSDSDSDSDSSSDSSSESETEKKPQKAKKAPVKKDDSSSSSSDSSSDSSDSESEKESAPVKSKAKKAKSVSSSSASSSSDSSDSSDSDSSDDDEPANVPLPDSDSSAASSDSSDSDSSSDSDSGSDSDSSSESEIEKKTSKKNKGKKAASVSSSSASSASDSSDSSDSSDSESDSDAKPTKAKAKKSGKKAATPSSDSSSSSSDSDSSSSDSSDSESEKVSKSTASERKGSASDSSHTIPAASPAPASNKRKAVSPSAEAPKSKRSHVENRFQRIKPDTQVDPRLASNAYVSYDYADRAHAKLIITKGKGFTKEKNKGKRGSYRGGMIDTSGGKGIKFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI76</accession>
    <name>M2TI76_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division cycle protein 123</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_349928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696023.1">
        <property type="nucleotide sequence ID" value="XM_007697833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TI76"/>
    <dbReference type="GeneID" id="19137991"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_349928"/>
    <dbReference type="eggNOG" id="ENOG502SD0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069412_0_0_1"/>
    <dbReference type="OMA" id="AISQYRW"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25128" checksum="96418007404D2541" modified="2013-05-01" version="1">MAHSNRQIPRSTGGEYHEIVIPGFLYEDMMRCHSAWVTTGHIHNAVLEEMLETLKSTKAGRELVSLLDGERKWFIRLGHMSSKDSPMGSGLPSLTVRDIMTKLCTSMRAYTCLQREKAHAEKEDKEMKIKLMLNRWDEGMHPGTEFRVFLTEYVIDMLLEHGFSFDVALERNSTVQLVEINPFGALSPCGACLFNWILDGKVLYGIEEGRFAMTLDEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIT4</accession>
    <name>M2TIT4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_186111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694540.1">
        <property type="nucleotide sequence ID" value="XM_007696350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIT4"/>
    <dbReference type="GeneID" id="19133547"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_186111"/>
    <dbReference type="HOGENOM" id="CLU_735664_0_0_1"/>
    <dbReference type="OMA" id="IRWEISH"/>
    <dbReference type="OrthoDB" id="10647831at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="376" mass="41309" checksum="29D8F38462C46054" modified="2013-05-01" version="1">MSLPLGVVRVGLAEMGYSNTSNRLIISFDVLQASPMLCVAASPEFESSVCMTCSPPTGSRARIATRTLIHEQRTWILSIYPWWGNALRTEAFKLTLDKTLGMSIFPSDRRASTPPLSMDLVARGVLRQYIHINLVTQQTMCYLASVGLHNYRAMVTGIHRPDSMPTSPVVAVLVLQSPNPRNPKTLVIHCPPNPGRRSLSLPPVPRKVGLGLPIPTASLPSLRSNRRPCLGPVTFGTFWPLPDPRHALALALVTSVSAPSSSSYLHVLLPEHPDLCARAADTHRSCLSASLALAHQRLTFHIHDPFLTRRLPSTSTHIHVDPPRPFLFPFSPYPSCTPLCSLRLLLVIRWEISHTTSSTLSHSPYPSICTDSPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJG2</accession>
    <name>M2TJG2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_80152</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696349.1">
        <property type="nucleotide sequence ID" value="XM_007698159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJG2"/>
    <dbReference type="GeneID" id="19140770"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80152"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="OMA" id="YMSEYWK"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF79">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="18">
        <location>
            <begin position="292"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMD68847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="411" mass="43686" checksum="A34F095833A8C734" modified="2013-05-01" version="1">MPSLRTLGKLAVGGAQIILGGGQRVMGDFTQACPNAQLSCHNTTAVENLCCFNAPGGQLLQTQFWDASPATGPDDSWTIHGLWPDRCDGSYDASCDSTRSYSNISAILTSFGATDLLAYMSTYWKDYKGHDESFWYHEWAKHGTCISTLEPECYTEHKPTEEVVDFFQKTVDLFKTLPSYEWLKEAGITPSTTQTYTFDAIQKAIQAKRPDVEVTLGCRSGALNEIWYHFDVRGSVQTGEFVPSNPDGTKSTCPRSGIRYLPKHGSGSQPSPPIITTTVAGGNPAPTAAPGTPFSGRGQLNVLVNGANKGCIISKGTWYTTGTCATFSATKVGENGFTLSSSKGKCGIVGGALACGNNVRTATGFSSADGLLAAGGNANWSADKVAHGSTQQKVYAGGDHSATFSISWQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJX3</accession>
    <name>M2TJX3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_166012</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion inner membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
            <orientation evidence="16">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="16"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694460.1">
        <property type="nucleotide sequence ID" value="XM_007696270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJX3"/>
    <dbReference type="STRING" id="665912.M2TJX3"/>
    <dbReference type="GeneID" id="19132425"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_166012"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="OMA" id="METGTLH"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000026">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0809">Transit peptide</keyword>
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        <location>
            <begin position="17"/>
            <end position="411"/>
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            <begin position="467"/>
            <end position="603"/>
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        <location>
            <begin position="20"/>
            <end position="25"/>
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        <ligand>
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            <begin position="43"/>
            <end position="58"/>
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        <ligand>
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        <ligand>
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        <ligand>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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            <strain evidence="11">ND90Pr / ATCC 201652</strain>
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Dhillon B."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
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    </feature>
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        <location>
            <begin position="485"/>
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    </feature>
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        <location>
            <begin position="493"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD69317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="529" mass="59948" checksum="1F8CCAFC5A9A6E8E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLW4</accession>
    <name>M2TLW4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_132771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695288.1">
        <property type="nucleotide sequence ID" value="XM_007697098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLW4"/>
    <dbReference type="STRING" id="665912.M2TLW4"/>
    <dbReference type="GeneID" id="19130867"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_132771"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="NSLACGP"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD70166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="262" mass="27473" checksum="5413FD87FED6B645" modified="2013-05-01" version="1">MENTTLFDVSGKVVLVTGGAKGIGRMISEGFVRNGATVFVSSRDAKACEAACKEMNALGKGKADFIAADLYKEDAAAYIAAELGKRTTKLDVLVNNSGSNWGESYDKYPAAAWDRVLNLNLKRVFQLTQAVTPLLEAAATPTSPARIINIGSVDGLRVPALETFAYSASKAGLHHMSRVLASHLGKRGITSNTIACGPFQSKMMKATLEKYQDVITGGIPLGRIGTPEDVAGTCIWLASRAGSYVNGATIALDGGSVVGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2QTD5</accession>
    <name>M2QTD5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_204388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705885.1">
        <property type="nucleotide sequence ID" value="XM_007707695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QTD5"/>
    <dbReference type="GeneID" id="19134290"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_204388"/>
    <dbReference type="eggNOG" id="ENOG502QQA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_0_0_1"/>
    <dbReference type="OMA" id="WTWYSIL"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="38"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD58434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="437" mass="47041" checksum="AFC6E4B0AAEDB3D1" modified="2013-05-01" version="1">MAHQSRSDENSPLLGDNSRTFVTPDQGASQEEPETMNMRLIFKIAAAMYSFATLGLFNSSIGAVLPLLSQHYNLSDIQVSSIFLAGPIGYVLAAQFSDAVHYRFGQRGIAFVGPILQVLATATVAVHPGFGLILVAFAFQGLGTGLLDGSWCAWAGSMKKANTISGLLHGSYSVGGALGPLLLTMLTAKHQHWWTWYSILAEACALSFIVQVAAFRHESASVYRQSKQSKMSDSKVDLREIFKHPATWLCAAFFLTYVGVETSISGWVVSFMLRERHASDYIAGLSSSGYWIGMAIGRLVLGFATDRMGVRRATVLYFLFAIIFEALFAAFSSLEASVIFMTATGFVHGPLFPSGVVVLTRLLPAELHVAAVSFVASLGQIGGAFLPFAIGAVVQGLGIGVFRFAILVETLLALLVWLAFARLRPALLPISAAHTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2QU70</accession>
    <name>M2QU70_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_103363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705744.1">
        <property type="nucleotide sequence ID" value="XM_007707554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QU70"/>
    <dbReference type="STRING" id="665912.M2QU70"/>
    <dbReference type="GeneID" id="19129841"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103363"/>
    <dbReference type="eggNOG" id="KOG1767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129470_4_0_1"/>
    <dbReference type="OMA" id="RIVHHSG"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="96" mass="10424" checksum="7749F0670738D297" modified="2013-05-01" version="1" fragment="single">APAATGGKKQKKKWSKGKVKDKAQHAVVLDKTTNDKLQKDVQSYRLITVATLVDRLKINGSLARKALADLEANGQIKKVVGHSKLSIYTRAIGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2QUC6</accession>
    <name>M2QUC6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_266038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007707589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QUC6"/>
    <dbReference type="STRING" id="665912.M2QUC6"/>
    <dbReference type="GeneID" id="19135521"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_266038"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013363_1_0_1"/>
    <dbReference type="OMA" id="QTPPCGQ"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="187"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="94143" checksum="246FC71C7A274A1C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2QW17</accession>
    <name>M2QW17_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_30755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="19"/>
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            <begin position="20"/>
            <end position="901"/>
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            <end position="558"/>
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            <end position="798"/>
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        <location>
            <begin position="781"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <begin position="205"/>
            <end position="352"/>
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    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF06985"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59529.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="669" mass="76859" checksum="9FBE42A53ADF7393" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2QXC9</accession>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <end position="172"/>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59719.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DNA LIGASE 1"/>
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        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
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        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="DNA_LIGASE_A1"/>
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        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="610"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="842"/>
            <end position="883"/>
        </location>
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            <begin position="63"/>
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        <location>
            <begin position="183"/>
            <end position="196"/>
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            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="842"/>
            <end position="851"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_200970</name>
    </gene>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="665912.M2R552"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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            <end position="58"/>
        </location>
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        </location>
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        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
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            <position position="91"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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        <source>
            <dbReference type="EMBL" id="EMD62289.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPROTEINA"/>
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        <property type="entry name" value="GPROTEINAFNG"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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            <end position="150"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
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            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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            <end position="271"/>
        </location>
        <ligand>
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        </ligand>
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        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EMD62404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40464" checksum="B5550553652C0738" modified="2013-05-01" version="1">MSTNNDDVEQKKRSQAIDRKLEEDSRRLRRECKILLLGSGESGKSTIVKQMKIIHQNGYTQEELAMYRLTIYKNVIDCAKALIGAMRQFDITCENPGNTELCEYLANYTVDPDPEKPLDQRVGQAITSMWRDPCVPKVLEHSSEFYLMDSAPYFFDEVERISDPNYVPIESDVLRARTKTTGIYETRFTMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESSQNRMMESLVLFDSVVNSRWFMRTSIILFLNKVDLFKAKLARSPLGNYFPDYSGGNDVNRAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILQNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2R7G9</accession>
    <name>M2R7G9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701003.1">
        <property type="nucleotide sequence ID" value="XM_007702813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R7G9"/>
    <dbReference type="STRING" id="665912.M2R7G9"/>
    <dbReference type="GeneID" id="19139097"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37816"/>
    <dbReference type="eggNOG" id="ENOG502SJ0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115019_0_0_1"/>
    <dbReference type="OMA" id="GWIEEWV"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="154" mass="17935" checksum="931C15059D27CCCC" modified="2013-05-01" version="1">MAANGHRDKGLPPSKYLCLTILGYRKPGLSEEDYRRHMIEVSAPLTKDLMAKHGIKRWTVIHNPQETRELMSELYDAQMANVADYDCFSQVVFESVGDYKRLREDPWYKSRLFGDHEKFADTSRSQMTIGWIEEWVHNGQIRESMDAPWPSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2R8N3</accession>
    <name>M2R8N3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_145679</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701492.1">
        <property type="nucleotide sequence ID" value="XM_007703302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R8N3"/>
    <dbReference type="STRING" id="665912.M2R8N3"/>
    <dbReference type="GeneID" id="19131353"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_145679"/>
    <dbReference type="eggNOG" id="KOG2575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008110_2_1_1"/>
    <dbReference type="OMA" id="FQVPPMH"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD63304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="585" mass="66295" checksum="7203281EAFAEB44C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2R900</accession>
    <name>M2R900_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_327571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700536.1">
        <property type="nucleotide sequence ID" value="XM_007702346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R900"/>
    <dbReference type="STRING" id="665912.M2R900"/>
    <dbReference type="GeneID" id="19136893"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_327571"/>
    <dbReference type="eggNOG" id="KOG2661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_1_0_1"/>
    <dbReference type="OMA" id="RFNCYSE"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="131"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD63414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="339" mass="37939" checksum="A1EA4033F750F664" modified="2013-05-01" version="1">MYRIRPPLQILSATHPPLPRPRPAQLRFYQQLPFGRGPRPQYKRFSSPSGGLSGLLYRWAARPTFYRDIGILSAGAGTIYLYNLEEVPVSGRRRFNIIPAQLEEAIGRSSVDQVRQQYAGRILPDNDVRVRKVKKVLQRLLPYAEGEGLQGLDWEVTVIESPEQNAFVAPGGKVFVFTGILPLCRDEDGIAAVLGHEIAHVVAHHTAERMSQAPLVLLGVLALSLFDISLYSGKLLIDLFLSMPASRKHEAEADFIGLMMMAQGCYRPQAAMDFWARMEKMGGGEPPQILSTHPSHHNREEKIREWLPKALEKAEASECYGTSQYANQFSSAFSGLGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2RA81</accession>
    <name>M2RA81_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_331680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700800.1">
        <property type="nucleotide sequence ID" value="XM_007702610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RA81"/>
    <dbReference type="STRING" id="665912.M2RA81"/>
    <dbReference type="GeneID" id="19137069"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_331680"/>
    <dbReference type="eggNOG" id="KOG1747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031995_0_1_1"/>
    <dbReference type="OMA" id="YLFKHTH"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="178"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD63789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="328" mass="35466" checksum="DCABAD1F2691FC3C" modified="2013-05-01" version="1">MQSGISASQELKSALGSLITSTSQRGILATIQKETIVPSGTISSTASTFVDDLSNLQPHVKDNAALYILLRRADSLNSSDKSLVAVTYVPNAAPVRQKMLFASTRLTLVRELGGEHFAESIFTTEASELTTEGWEKHVAHTESENPLTAEEQSLQDIKAAEALESRGTRGQSLAQGGKLAIRADNDVAEVLKKLGQGGGDNLVQLRMDGASETLKLVSSSSATPSSISGSIDTKEPRYVFYRHNDPDASIVFISTCPSSAKIRERMIYAASRGNVVSLAQNDGGLKVLKKLEVTNPDEITEQIIMDEFKEEKKEESKGFAKPKRPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBP6</accession>
    <name>M2RBP6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_36846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699806.1">
        <property type="nucleotide sequence ID" value="XM_007701616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBP6"/>
    <dbReference type="STRING" id="665912.M2RBP6"/>
    <dbReference type="GeneID" id="19138834"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36846"/>
    <dbReference type="eggNOG" id="ENOG502QTX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_1_1"/>
    <dbReference type="OMA" id="LMTRPHR"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD64269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="413" mass="45820" checksum="9F4F4C11865DC313" modified="2013-05-01" version="1">MALSTPPQLKVLINGAGIAGSCLAYWLTRARLNASITVLERSPSPRVTGQSIEIRGTAISIVDKMNLLPEVLARNTTEQGTRLVNASNKIIAEFGKGEAFTSEYEILRADLCGIFLDATRNAPNVQYQYGDHVTSVSQTSDKVNVQFHSGTTDSFDLIVGADGSTSRIRSMVLSDEAQKNCYNFIGQYIAYFSIPRIPSDTNHWYWYNAPKGLALMLRPHRNDRTVGCYMGVTTPAHGHRDPAAEKAMEGGPQAQKEFLTEYFKDAGWQAQRILKGMHRSDDFYMSRSAYVKLPTWTNHRAVLLGDAAHATFGSGTTLAVQGAYYLAGELGKVRRSEDVPDALKRYEKVFRPVQAVDGTLPPGFPQMAFPQTEWGLRLRDAIAWAVAKSKVYKLLPNDKPDESQLPVYEWTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RDX5</accession>
    <name>M2RDX5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_199192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699512.1">
        <property type="nucleotide sequence ID" value="XM_007701322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RDX5"/>
    <dbReference type="STRING" id="665912.M2RDX5"/>
    <dbReference type="GeneID" id="19134087"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_199192"/>
    <dbReference type="eggNOG" id="ENOG502QRVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050424_1_1_1"/>
    <dbReference type="OMA" id="TVWEVKD"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD64984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="331" mass="37041" checksum="E6553D3F2233063C" modified="2013-05-01" version="1">MGFGDFQTICEKAPIPLCAAVGHQDISNGVGIQTRCYARTIEIANTLIFEAANDFMHILALVMTVVMIIHVRSKFTAVGRKEITTFFYIYFLLTIISLVLDAGVTAPGSATYPYFVAAQNGLTSALCTCLLINGFVGFQLYEDGTTLSVWLLRLSSLAMFIVGGAVNLLTFKGWAGLSFMNPIGIFIVTYLVNAICLFIYAVSQIILVIGTLEDRWPLGDILFGIFFFVIGQVILYVFSDTICEGVQHYIDGLFFTTICNLLAVMMVYKYWDSITREDLEFSVGVKQHNWEIKEPYPEEERRGTMYQDSDYTPSLYQQPHGRNSHYSAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2RET8</accession>
    <name>M2RET8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_303970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698492.1">
        <property type="nucleotide sequence ID" value="XM_007700302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RET8"/>
    <dbReference type="GeneID" id="19136238"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_303970"/>
    <dbReference type="HOGENOM" id="CLU_1643409_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="168" mass="18503" checksum="2B4EE74F42ADF77F" modified="2013-05-01" version="1">MNQVIIYRHVTDDIPMHPGTSLSAEGIRAIMNKPEYGLAHVGGTFGDFGNSSVGGRKICDNCYLLPGTRYARGIAEKGCIPHEQNNRVCTNCLAFGRPYCSWTADLSADSQPMIEKFRYLLGYLPIKDVSSSMQGFTQQFISLPDEPMLEDDGSEGGNVEDENGRDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2RIT1</accession>
    <name>M2RIT1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_300295</name>
    </gene>
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    </feature>
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        <location>
            <begin position="189"/>
            <end position="229"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66614.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="229" mass="24855" checksum="517997D96D2B5BCD" modified="2013-05-01" version="1">MVTLPILSHTLQSTQSLSNRAEKLEEAESALPGIKRGIAIGIACSVSVVLIAILAFLAIRRRNRILAQRLQQQTQEAGGVEAQQEKTWWPHAPPLVLPVATLPPPPPVEADAHIIHELDAGQTPELHGDTRPQEVDGAGKPQNAPEEAEELYVQRLKQWKDWNTVSEADPAQPNNEVTRWSVPLLMVSPPGTTRGDVSPLLRSSWDLSSRGASPISPPATTHFPAGHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_84188"/>
    <dbReference type="eggNOG" id="KOG2319">
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    <dbReference type="OMA" id="WSQVMYW"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="Dilute_dom"/>
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    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
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    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIL"/>
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    </dbReference>
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        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
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            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="730"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="808"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD66664.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="808" mass="91671" checksum="3B784C2CB2803528" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RK57</accession>
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            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
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            <taxon>Dothideomycetes</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_351784"/>
    <dbReference type="eggNOG" id="ENOG502SHJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_0_0_1"/>
    <dbReference type="OMA" id="RNWQILP"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF152">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="24"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD67069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="355" mass="40087" checksum="A9CDC0F5AA932A65" modified="2013-05-01" version="1">MLDPNAILTECRVEYAIGSAIILLRFFARWKIAGWRGFYWDDFFAFSSWVFFTMIYAMVEFLNVTGAPIAMTQEQREALPPATRKSMREGAKAMFASFYFLIFLVWSLKGCIIVLFLRFTRDTPLYQYVQMIGGVSIAACIAAIITQTTHCLPLKRNWQILPDPGKECSAGVVINIVIAVGNVLVDALLIVVPFWMLKDSHIRLWRKIRIVFLLSLGLFVMGMATARCILSIGTSVQVALASVWAQREAVVSIFAVNAPVINGLFRAEAWATRKYTSDYSSKYSRTYSNPLHKKKKSGFEIYKMTDFETKMSDMETARRESIVELVTDPSVASSASQWRCSVEAASQKGHPRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2RK63</accession>
    <name>M2RK63_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_83478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696823.1">
        <property type="nucleotide sequence ID" value="XM_007698633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RK63"/>
    <dbReference type="STRING" id="665912.M2RK63"/>
    <dbReference type="GeneID" id="19140959"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_83478"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_0_0_1"/>
    <dbReference type="OMA" id="EASHAEI"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD67074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="381" mass="44086" checksum="6D1B1799C13A6A47" modified="2013-05-01" version="1">MAESASPIGIANLPNQRHKIVAKRGAAFTIMVAGESGLGKTTFINTLFSTTIKNYADHKRRHHKQMDKTVEIEITKAELEEKFFKVRLTVIDTPGFGDYVNNRDSWQPIIEFLDDQHESYMLQEQQPRRTDKIDLRVHACLYFIRPTGHTLKPLDIEVMKKLCTRVNLIPVVAKADTLSPTDLARFKMRVRQVIDAQGIKIYTPPLEDDDAAAMQHARSLIDAMPFSVIGSEKDVQTNDGRTVKGRQYAWGVAEVENEEHCDFKKLRAILIRTHMLDLIHTTEENHYEAYRAGQMETRKFGEARPRKLDNPKFKEEEEALRKRFTEQVKVEEQRFRQWEQKLIAERDRLNKDLEASHAEIKRLEGEVDALQGSINRSHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2024-05-29" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2RKI4</accession>
    <name>M2RKI4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_287123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696912.1">
        <property type="nucleotide sequence ID" value="XM_007698722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RKI4"/>
    <dbReference type="GeneID" id="19135900"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_287123"/>
    <dbReference type="HOGENOM" id="CLU_2885633_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="63" mass="7285" checksum="A914686B9BCC6CF2" modified="2013-05-01" version="1">MKVKIPLSSSPSQNFHHLFPHIQGNLTNTHAHHHASIIDHPPRYRSGASRKIPKQHMYTSWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2RN22</accession>
    <name>M2RN22_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_167294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695747.1">
        <property type="nucleotide sequence ID" value="XM_007697557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RN22"/>
    <dbReference type="STRING" id="665912.M2RN22"/>
    <dbReference type="GeneID" id="19132502"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_167294"/>
    <dbReference type="eggNOG" id="ENOG502SSXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_774193_0_0_1"/>
    <dbReference type="OMA" id="LRIDCAI"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="37"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="358" mass="39622" checksum="8AD04FC711208958" modified="2013-05-01" version="1">MAGSITDNRFDIINGKQLALLIAPLFCFVVASAAVAARWYTRSVRRINTLTEDVLMLAALAMSFAVVTIVYVLVFLGGEGLTSDQIKADPTKNFHVVNRFWLRLQFALDICWATSIATVQIAFAKAYLRLYERKRIAQTACWCSIGLISIWYIWSLAGWISMCHPPGKCELQSKKSCIIIGSLHVFFNSVILFAPVPAILAAELSAKKRWSVMILFLLGCFCTILAVLRIDCAINVFGDVDEDPIGASWWRVCFSPIEVAVGIVCCCVPNVRSLPSWRRASPIASNESHGLRRLKFRTTSSGSSTSNLNEPSQWMPHASKPQAAAFVTLTSDSDTLERTGSLGANEIKITKEYNLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2RRY5</accession>
    <name>M2RRY5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_155532</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694692.1">
        <property type="nucleotide sequence ID" value="XM_007696502.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2RRY5"/>
    <dbReference type="GeneID" id="19131702"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_155532"/>
    <dbReference type="eggNOG" id="KOG0939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000215_0_1_1"/>
    <dbReference type="OMA" id="ADEMKYG"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="3618"/>
            <end position="3954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="271"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1132"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1479"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1906"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1976"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2288"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2351"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <begin position="3248"/>
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        <location>
            <begin position="278"/>
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        </location>
    </feature>
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            <begin position="319"/>
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        </location>
    </feature>
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            <begin position="1137"/>
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        </location>
    </feature>
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            <begin position="1514"/>
            <end position="1523"/>
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            <begin position="1909"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="1989"/>
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        </location>
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            <end position="2320"/>
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    </feature>
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            <position position="3921"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD69339.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="3954" mass="440246" checksum="D0A21F04811AFCFE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSI1</accession>
    <name>M2RSI1_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_73662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445665">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="RNaseH_sf"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="79" mass="9556" checksum="C4C59E24C20BED9A" modified="2013-05-01" version="1" fragment="single">VLIAAGYNKTKLTRKPGLTKKMRQERLNWCLAHKDWTLEDWKNVIWLDETSVVLNHRRGSYRVWRKSDEAFTRSVIRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT52</accession>
    <name>M2RT52_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_350759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705856.1">
        <property type="nucleotide sequence ID" value="XM_007707666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT52"/>
    <dbReference type="MEROPS" id="M19.013"/>
    <dbReference type="GeneID" id="19138041"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_350759"/>
    <dbReference type="eggNOG" id="KOG4127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_4_0_1"/>
    <dbReference type="OMA" id="SRHNVFG"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="416" mass="45683" checksum="09D783D93A5A54A2" modified="2013-05-01" version="1">MDSVEKTQQSVPSVVLDKKRSTRTSWKLKAFSILLLAGFAAVRTWISRTVDPLGQVLGHVPLIALDGHNDFPIFIRAFYYNHIYGSNFSDAIDLVGQVDFPKLERSRLGAQFWSAYVECPRDGGDASDQATFYEAMHQTLQQIDLINRLIDAYPKRLQRAASASEVWAQFADPKRTGISSLMGIEGLHQVANSASFLRLVYQLGVRYVTLTHSCHNAYADSCSPHEPLNGGLSEAGRDVVLEMNRIGLMVDLSHTSVATQRDAFNVSRAPVVYTHSSARALCEHPRNVADEELWALKANGGIIMVNFFPGFVTCNAQATLEDVADHIIYLGNLIGFEHVGIGADFDGMGFDKGPVGLEDVGTYPALVAELLRRGVSVTEVRGVAGANILRVLARVEEIAHVIANQQPLEDQVKSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT59</accession>
    <name>M2RT59_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_350774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705861.1">
        <property type="nucleotide sequence ID" value="XM_007707671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT59"/>
    <dbReference type="STRING" id="665912.M2RT59"/>
    <dbReference type="GeneID" id="19138042"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_350774"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_2_1"/>
    <dbReference type="OMA" id="FAMPWMF"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF20">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 1 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="116"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD58403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="247" mass="28201" checksum="5B88ED9BA1E3F1EF" modified="2013-05-01" version="1">MSGTEVAQKRPNGEVVIGDVECDGRTILYVIRADQTSYINYIKPLILAEELGFPHLLSVIDTRDEWFYAVHPERMVPSLKDRDDETGEKIIVFEGTACLQYLAAKYDKQGQWTGRTAWEKAQVLSWTAFQTAGLGATAKYWLYFLRGYPSRQNPEPMPRTCAKLHVNTLKAWDMLEARLALEEQKYIALPDRPTLADISYFPFSMPWMFGFFGVDINNWPNIKLWGEVMMARPAIQKVMATAPSIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RU74</accession>
    <name>M2RU74_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_154445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705769.1">
        <property type="nucleotide sequence ID" value="XM_007707579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RU74"/>
    <dbReference type="GeneID" id="19131668"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_154445"/>
    <dbReference type="eggNOG" id="ENOG502QRUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026100_0_0_1"/>
    <dbReference type="OMA" id="ASWDIQT"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="60510" checksum="3A492285F35F8A42" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RVR0</accession>
    <name>M2RVR0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_41023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704834.1">
        <property type="nucleotide sequence ID" value="XM_007706644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RVR0"/>
    <dbReference type="STRING" id="665912.M2RVR0"/>
    <dbReference type="GeneID" id="19139892"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41023"/>
    <dbReference type="eggNOG" id="KOG3263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075596_3_0_1"/>
    <dbReference type="OMA" id="VDSSTMW"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="153"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD59143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="211" mass="24159" checksum="194792F68BFF7E21" modified="2013-05-01" version="1">MSDNERPRDRFRERDSRREPREGRERGGTPTERRNRSRSPRDRGSRCDTRYRSRSPYRKDERDGAGRGGDRARPGAGHDRGRGRDDRRGGRDDRPSFRDRSPQPPKGPRGSARGPFGGSAKPPTGPRSADAVKEETPDVEMKDERQKPEDMDDDEWEMLKVMGFGGFKSTKNTKVPGNDKNYGVRKDKQLQARQYMNRQGGFNRPLSPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2RX70</accession>
    <name>M2RX70_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_40808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="6"/>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704494.1">
        <property type="nucleotide sequence ID" value="XM_007706304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RX70"/>
    <dbReference type="STRING" id="665912.M2RX70"/>
    <dbReference type="GeneID" id="19139841"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40808"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_0_1_1"/>
    <dbReference type="OMA" id="LNEPALY"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF8">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024522" description="glucan 1,3-beta-glucosidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="89"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD59638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="422" mass="47233" checksum="E7D61CD545D41DAB" modified="2013-05-01" version="1">MILTKLFSTLSLCAAVLAAPAQQKRAVGFNWGSEKIRGVNIGGWLVLEPWITPSIFDNANRGRPQNDIVDEYTLGEKLGSQNALNILRNHWDTFVTWQDFNKIKQSGFNVVRIPVGYWAYDTFGSPYVSGAAVYIDAAIDWARSVGLKIVIDLHGVPGSQNGFDNSGQRMERPTWQQGDTIRRTLQVLRTISQKYAQKSYQDVIIGIQLLNEPALYNGLSRDVLAQFYRDGYGQVREVSDTPVIISDGFTAPNSWNGFLAPSDANARNVAIDNHQYQVFDSDLLKLSPAGHAQQACRNTGAYGGADKWTFVGEWTSAMTDCARYLNGYGRGARYDGTYLGNLKLGECGWRNDLAQWPASYKDDSRRYIEAQIRAFESTTQGWFWWNFKTEGAAEWDAFRLIDAGVFPAIRNGQVEYKFGAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2S0E3</accession>
    <name>M2S0E3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_174978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19300" checksum="E7F118AC15F569B3" modified="2013-05-01" version="1">MSKPTIVFETEAVAHPSVGAEPPNKGLEDDTAALRSTLERLSDDGKNIFLVMHSYGGLVGKNALKGLGCKQRIVYYHDLDDEAHKSAITRLKHQSARIFTDEVTYEPWYEIPMYFFCEANKALLLPIQQQMAQTLGKDAPTFKSVESHLPFLSQALEIVQSLEYAAKVGQSKK</sequence>
</entry>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_149856</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
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        <property type="protein sequence ID" value="EMD61213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_149856"/>
    <dbReference type="eggNOG" id="KOG1238">
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    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
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    <dbReference type="OrthoDB" id="269227at2759"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
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    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
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    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
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    </dbReference>
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        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMC_oxred_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD61213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="543" mass="59907" checksum="17A195D67135F11B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2S3S1</accession>
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            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
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        <name evidence="10" type="ORF">COCSADRAFT_146943</name>
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        <name type="common">Common root rot and spot blotch fungus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_146943"/>
    <dbReference type="eggNOG" id="KOG1286">
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    <dbReference type="OMA" id="KSYLAMP"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
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    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701938.1">
        <property type="nucleotide sequence ID" value="XM_007703748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S664"/>
    <dbReference type="GeneID" id="19134182"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_201222"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="OMA" id="WIQIWNN"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD62608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="59674" checksum="1366EC5AB0858D19" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SA98</accession>
    <name>M2SA98_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_41300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704901.1">
        <property type="nucleotide sequence ID" value="XM_007706711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SA98"/>
    <dbReference type="STRING" id="665912.M2SA98"/>
    <dbReference type="GeneID" id="19139959"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41300"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_6_3_1"/>
    <dbReference type="OMA" id="RMPLMVT"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD59455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="447" mass="49235" checksum="8A8F2840220552EF" modified="2013-05-01" version="1">MAPQRYEAEHRDPAPLGKPLDFVFSKRTAQNRFLKGAMTERLSSFDPDVLEIRGVPSKELVNVYRRWGEGQFGVILTGNIMIEYDHLEAAGNPIIPRDAKFEGERFEMFKEIAVQSKKHGSLIVGQVSHPGRQVTENIQKNPISASDVQLTGNPMGMSFAKPRAATEEDIKNVINGFAHAAEYLEKAGYDGIQLHGAHGYLLAQFLSPSTNLRTDAYGGSLENRARIITEIGQEIRKRTSPSFILSIKLNSVEFQDKGFNTEDAATLCQLLESNSFDFVELSGGTYEHMAFKHQRESTKKREAFFLDFAEKITPSLSKTKTYITGGFKTAPAMIDALSTVDGIGIARPVCLEPELTRQILAGEVDAAIKQRMEDGDFGTAIAAAGAQIKQLGKDEQPIDLSDEGNYAAFLKDLGAWAEELKKDSKRYGHMDVKSVKAVPYGAPLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2SC37</accession>
    <name>M2SC37_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_175148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704291.1">
        <property type="nucleotide sequence ID" value="XM_007706101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SC37"/>
    <dbReference type="GeneID" id="19132949"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175148"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
    <dbReference type="OMA" id="KQFNNHM"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="231"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="410" mass="45930" checksum="6F2B67700385CC98" modified="2013-05-01" version="1">MAVLDGGIAVHANDPGAVPKILEKLLMFRKSTITEGNDGRLDMLALARSLVVALETPRETMIKHNWVQPGCHTAITACYNAGVFKLLAEKDGPIKVDEIAGELGVPRQTLARMMKHIAAMGYIKEIGTDEYAPTNFSKALDMPIIGDSYPCLAGGAHPSCSKFPEYLKGTNYELTSDVESGPYQFAFNTKMSMFEYMIVHPPLGHQFNHHMSGYRQGRPSWMDRDFYPVKERLVKEMNASKDAVMLVDVGGGHGHDIEEFRLKHTDAPGRLILQDLSPVIDGIEHLHNDVERMKYDFHTEQPIKAARAYYLHSVLHDWPDEVCKSILKQVAGAMKQGYSKLLINEIIIPDQGADSEATGLDMMMMTLFSSKERTMEEWKRLLESPGLDLKIVKVWSVKHSQESLIECELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCD5</accession>
    <name>M2SCD5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_116197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699494.1">
        <property type="nucleotide sequence ID" value="XM_007701304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCD5"/>
    <dbReference type="GeneID" id="19130315"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116197"/>
    <dbReference type="eggNOG" id="ENOG502S819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161487_0_0_1"/>
    <dbReference type="OMA" id="CNTLCND"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025650" description="EGF-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13906" checksum="78F2254944069309" modified="2013-05-01" version="1">MKTLTIVLFSLMSLAYAGEPVCQQCDYRPGYNLCDITTSCTFVWGHDDPSTPAPYYCACRAGYRADNCEAGDTTQQFRLPWYGTPGGDPSQQGRVFVKPGVSCNTLCDDYTLGKDGCKAVKELDSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SE44</accession>
    <name>M2SE44_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_346112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704009.1">
        <property type="nucleotide sequence ID" value="XM_007705819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SE44"/>
    <dbReference type="GeneID" id="19137757"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_346112"/>
    <dbReference type="HOGENOM" id="CLU_3147158_0_0_1"/>
    <dbReference type="OrthoDB" id="10375726at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD60730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="61" mass="7007" checksum="CB01BAEC12793584" modified="2013-05-01" version="1" fragment="single">FDFKITYRAGTLNRVVDAVSKRSDLREEGYKELYNALLKKMPNSSLKYNQPELAKVAKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SF77</accession>
    <name>M2SF77_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_35888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698426.1">
        <property type="nucleotide sequence ID" value="XM_007700236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SF77"/>
    <dbReference type="STRING" id="665912.M2SF77"/>
    <dbReference type="GeneID" id="19138594"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35888"/>
    <dbReference type="eggNOG" id="KOG0031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054966_1_0_1"/>
    <dbReference type="OMA" id="PPLLHSM"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD65928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="387" mass="40854" checksum="9073EE9444C409EB" modified="2013-05-01" version="1">MDSTTPTPYKPSPLSFNNARQSPFRRPGSIREASPSTLRPSTPNSSPLKPKDTPNTPSQANLRPTAAAAAAPATATGPVSQNPPPWLHTRTRSGTPEPPASPGRHVSPTRNAPPPTAQGTGRPLSTASIAAMFEGTAKDDTPAPLSFRKQSPPVDPVKPMERPIEKPAEVHVDRFAHLSPAPSPARSPARSREPSPGRLAARPPTIRRMASSDALSKLPPPLLHSMRESFSVMDRDDDGHVNAADVADMLSQLGLSATPSQLSTYFNGAQSINLANYLTTLSDLLGNLSHQSELSAAFEAFDDNDDGQIDLAELKDALLHTAPQPGETLLTEREINMVVEGFSGRRAFGKGGKGLGRGEVFRYHDFLANLTGGGNGGDNTEGAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIY9</accession>
    <name>M2SIY9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_82233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696883.1">
        <property type="nucleotide sequence ID" value="XM_007698693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SIY9"/>
    <dbReference type="STRING" id="665912.M2SIY9"/>
    <dbReference type="GeneID" id="19140880"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82233"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_1_1"/>
    <dbReference type="OMA" id="CERTEET"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="202" mass="23140" checksum="D0CC51F887B7FF38" modified="2013-05-01" version="1">MSFQRVGQKSWLDVFPLKKYVYKSNAEDKHRTLFVDVGGGYGHQCRETLKRFPWLQGRVVLQDTHEAAIDSAMAIEGLKVVHHDFTKPQPVKGACVYYLRNILHDWPDQACYNILSQIKEVLAPDSVILLDELIIHDEGAHWYGASFDLLMMANYGARERSLNEWDRLLETVGLERKTFVPYSMHGDGIQVVGVRGTIHENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJR3</accession>
    <name>M2SJR3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_23804</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696439.1">
        <property type="nucleotide sequence ID" value="XM_007698249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJR3"/>
    <dbReference type="STRING" id="665912.M2SJR3"/>
    <dbReference type="GeneID" id="19134925"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_23804"/>
    <dbReference type="eggNOG" id="KOG0426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="OMA" id="APDGMFT"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD67423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="165" mass="18552" checksum="566BF1C7C821F390" modified="2013-05-01" version="1">MASTAAKRLFKEYRALSSDPPEGITAGPVNEDDMFIWEALIQGPEGTPFEGGVFPAELRFPKDYPLAPPKMKFITDMWHPNVYPNGEVCISILHAPGEDPMQYEQASERWSPIQSVEKILISVMSMLAEPNDESPANVDAARMWREKRGEYENIVRANVRKSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKU3</accession>
    <name>M2SKU3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF410-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_137125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697350.1">
        <property type="nucleotide sequence ID" value="XM_007699160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SKU3"/>
    <dbReference type="STRING" id="665912.M2SKU3"/>
    <dbReference type="GeneID" id="19131036"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137125"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046061_0_1_1"/>
    <dbReference type="OMA" id="LMDMMGM"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000272">
        <property type="entry name" value="DUF410 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35487" checksum="A4DB8D33644480BB" modified="2013-05-01" version="1">MASKIEKTLARQREKIAEGQYYEAHQQLRVIASRYTKASDWPNATSILFQGAQSLLQAGQGGSGGDLCIFLLDVYNKGEIKVDAESKGRLLTLLRAFPKDEPTKKKFVGEMIVWSSRFGDFPAGDPELHHVAGGLYAEELEPYEAERHLLLGTQDSAATLASLHYNWYTSDAPHTAPLYCARGVLPYLLTGNLRAANKFFLLFTSAVEKTPNPPTQAVSTKSSEFRVYPSLPLLNFLGLLLLSVERGDPSLWRQLKSHYAGDLKDVNWGEALDQIGEMYFGIKIPRQGNPMFDMLGSMFGGGMGGGNGGAKKAVGGRAPPTAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2SLI5</accession>
    <name>M2SLI5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_156504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695753.1">
        <property type="nucleotide sequence ID" value="XM_007697563.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SLI5"/>
    <dbReference type="GeneID" id="19131767"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156504"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_0_1"/>
    <dbReference type="OMA" id="CCEGGLS"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CATATPASE"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="726"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="8">
        <location>
            <begin position="578"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
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            <end position="170"/>
        </location>
    </feature>
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            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
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            <begin position="1282"/>
            <end position="1304"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <begin position="1295"/>
            <end position="1304"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD68038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1304" mass="143829" checksum="D64E5CA7E2A86175" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SM13</accession>
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            <fullName evidence="2">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">COCSADRAFT_73266</name>
    </gene>
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="91"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD58186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="91" mass="10670" checksum="D17EDE2DB3E857D7" modified="2013-05-01" version="1" fragment="single">KLNPRVQPYYLTGYLSSNLYRLIDLKSNKIVTARDVRILEGVFNDQAHDHESQLEIDREINQETDQNLHPKRDQMKTSKIDQNVDQSTNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMQ1</accession>
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        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697859.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19135651"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_272820"/>
    <dbReference type="eggNOG" id="ENOG502R145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072364_0_0_1"/>
    <dbReference type="OMA" id="YCTREMA"/>
    <dbReference type="OrthoDB" id="3746964at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26645" checksum="88D7672D663E5607" modified="2013-05-01" version="1">MLRFDIILKLALVPSILYLLISVVSVALTTHYWILTDWVVSRGVLVKTSEFDERARQFVTDATIVYFTDADTDATIVSGCLNLAAAVIAIIAWSTLRKPGMDALINSTVRRFWILSLVFMSLAGAVMAIVSLALHYTKLGNDRWGCTQERLMMSGKMNTNVYCTREMAACRFQPEFVTGRDKQNASVACNEATVVKWMQIILLLLGLTVLSMFSLQAYLRRTSRETRLMGQGALTEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMU2</accession>
    <name>M2SMU2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 14">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_204418</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 14"/>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705916.1">
        <property type="nucleotide sequence ID" value="XM_007707726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMU2"/>
    <dbReference type="STRING" id="665912.M2SMU2"/>
    <dbReference type="GeneID" id="19134293"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_204418"/>
    <dbReference type="eggNOG" id="KOG3675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011977_1_0_1"/>
    <dbReference type="OMA" id="QRYWIRD"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="15">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD58471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="703" mass="79089" checksum="C4F8011E3D0722B5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMW5</accession>
    <name>M2SMW5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_161027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700691.1">
        <property type="nucleotide sequence ID" value="XM_007702501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMW5"/>
    <dbReference type="GeneID" id="19132081"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_161027"/>
    <dbReference type="HOGENOM" id="CLU_2978803_0_0_1"/>
    <dbReference type="OrthoDB" id="3799441at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="58" mass="6639" checksum="6C1F0C9433EC68AD" modified="2013-05-01" version="1">MASSWTAEAIIAFITLLATCISLGFMIRQMIRGKRTRTDYEFDLEGRGEIALERRNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMY4</accession>
    <name>M2SMY4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_350130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMY4"/>
    <dbReference type="GeneID" id="19138007"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_350130"/>
    <dbReference type="eggNOG" id="ENOG502RDG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="CKMLHTE"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="81"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="381" mass="44020" checksum="E5D1ECFFD9C90479" modified="2013-05-01" version="1">MAIHTSNRPYHPLRTPGDAIVNAAGQRVVLKGTALGRYLNMENFITGYSGHEHEHKTALASVPGKEKAQFFFDRLLQHFFTEADAEFFAPLGMNCIRIPFNYRHFIDDQNPTHFKKKGFELLGRAVNICAKYNLYVVLDLHAVPGGQNQDWHCDSGLNKALFWDFRVFQDQAIELWKAIAAIAAHYNGNPVVCGYNLLNEPADPQHVRLISWYERVEKEIRAVDPETMLFIDGDTYTMDFTYFQNVLPNSVYAYYDYAMFGFPIPGQPLYTGSKEQKSKRIRQSDRKVFFMREKNIPIWNGEFGPVYADEHTDPEAVKTNNARYHMLQDQLEIYARGQVSWSIWLYKDIGYQGMMYVSPDMPYMKLIAPFVATKQNLALDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SN28</accession>
    <name>M2SN28_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_104528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445673">
        <property type="protein sequence ID" value="EMD58182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706117.1">
        <property type="nucleotide sequence ID" value="XM_007707927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN28"/>
    <dbReference type="GeneID" id="19129917"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104528"/>
    <dbReference type="eggNOG" id="ENOG502RP5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053170_2_0_1"/>
    <dbReference type="OMA" id="WITTWEM"/>
    <dbReference type="OrthoDB" id="3711801at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49715" checksum="B7F9BB9427C4C726" modified="2013-05-01" version="1">MSNHATRDATVILTDSNNWTAWYRQLKIKCESLKIWALADPEGSQEPQPKPTLPLPPVLSNYESIATLPSITSTASSSRTRGNTQPSRRDEPIVVDIPTRVSDLTTSGREEYREDREDYKMRMEAYRFLEKEYKEEQAKYEKLLVHILGTVSPHLQLSCCHTGNSVREWIKSLQETVGVDPEEERIRARERYLGALRPMRTPNNWEPWLMEYDQAATRAEALEVSEVRNTKDVIRDFLDAVTKVAPNWVATFSGPGYDKAAMDRKKVMKLFREHMSQSNPTKGKQKSAFAAGEASFLAGGESDQDTLRDASDVSQRAPPAQSQGNLGKPGKKRKRDGQETKSKQFPKRNTAAAGDECPACGQRHNLSDCYYAFPEKAPDWFKPNRTIARLVEHRTKFDNELQGAMNSLIPTRREARLTSSSRSSSTPQMKMSQTPDAQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPC6</accession>
    <name>M2SPC6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_166068</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694504.1">
        <property type="nucleotide sequence ID" value="XM_007696314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPC6"/>
    <dbReference type="STRING" id="665912.M2SPC6"/>
    <dbReference type="GeneID" id="19132427"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_166068"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OMA" id="EAIFPMV"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="190"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD69063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="363" mass="39708" checksum="17B2AEFB89CD95A8" modified="2013-05-01" version="1">MPYPETTDAFAVTDIKNWSNFTRKELPLKKFEEHDVDIAIDACGVCASDVHTISGGWGESIPLPLCVGHEVIGKVVKVGSKVTKVKVGDRAGIGAQIGADLTCDQCKNDQENYCPNSVDTYGAKHTDGTVAQGGYASHIRGHEYFVFKIPDNIETSLAAPMLCAGLTTYSPLKRLGAGPGKKVGIIGLGGLGHFGVLWSVAMGADTYVISHSPNKKDDALKMGAKDFIVTKDKGWSEPWKFHFDFVINTADATDKFDLAEYFSILKVNGTFHMVGFPDNPLPPMPAQIFAPNGCYMGASHIGNRPEMEEMFELASKQNIKSWVQEIQISEEGCKEAVERVYKNDNVRYRITLTGFDKVFGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPL3</accession>
    <name>M2SPL3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_41618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705266.1">
        <property type="nucleotide sequence ID" value="XM_007707076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPL3"/>
    <dbReference type="GeneID" id="19140027"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41618"/>
    <dbReference type="eggNOG" id="ENOG502SHVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_0_1"/>
    <dbReference type="OMA" id="DKYEWYK"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF52">
        <property type="entry name" value="DSBA-LIKE THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="228" mass="25805" checksum="96C5586534A1F3E6" modified="2013-05-01" version="1">MPYESTIIFTLDTICPWTYIAFVRLNEALDAYRSANPDSPTKFTLKLAPYQLYPDFYEDGIDKYEWYKEKKYNGSDERMKAYAYYMGLSGKGEGIKFDFEGGSISNTLHAHRILYWLQNTKGPDAATKAALSLYSQYFEHRADPAGRETLEKVCIAAGLGEDEVKKVVGNQEEGLREVKAAIREQAGNGVDSVPYVVFEGKKRDFTHIGAKSVKEYVKVLVQVEKECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPL5</accession>
    <name>M2SPL5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_41800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705589.1">
        <property type="nucleotide sequence ID" value="XM_007707399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPL5"/>
    <dbReference type="STRING" id="665912.M2SPL5"/>
    <dbReference type="GeneID" id="19140077"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41800"/>
    <dbReference type="eggNOG" id="KOG4776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062474_0_0_1"/>
    <dbReference type="OMA" id="LDWAAYV"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="275"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="363" mass="40154" checksum="3C971524877EB2DC" modified="2013-05-01" version="1">MPHTYGDEDLEVASNKYHESSDEDFDPNAAPAEDASSSEDEDHVTIEPTQRKGKRKAPQNEELDSGDEVTIQAARRKRSKKKGGKGNKDDDAELIISDDEGGEGGLVKTRAQRRTEGKEARPLARTEGATVDVDALWAQMMAAPLKPLQESKTQKSDTPTQHTPVINIQASAEEEEQLSIKKTFTFAGQDTTEEKQIPRSQLDKYLKDGWKQTEATPAIKSPAHSSDQADSKIRRPLRRPSRFDPNPTGYVRALAPEFQLSWPRTSARPEPETGAEADADAHPSFPKKAEKTQKLNVVDKSRMDWTGFVDKEGIAEELDTHGKTKEAYLGRMEFLAGVEARKEEERRNAKIKAVAAAAAHTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPS3</accession>
    <name>M2SPS3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_41863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007707424.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SPS3"/>
    <dbReference type="GeneID" id="19140102"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41863"/>
    <dbReference type="eggNOG" id="KOG0265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="OMA" id="SGRVWLC"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="296"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="827"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="869"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="911"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="953"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1036"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1078"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1120"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1162"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1204"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1246"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD58762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1386" mass="153950" checksum="A88A8FAC55ED186D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQ51</accession>
    <name>M2SQ51_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytokinesis regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_203682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705013.1">
        <property type="nucleotide sequence ID" value="XM_007706823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQ51"/>
    <dbReference type="STRING" id="665912.M2SQ51"/>
    <dbReference type="GeneID" id="19134269"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_203682"/>
    <dbReference type="eggNOG" id="ENOG502QX1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008906_1_0_1"/>
    <dbReference type="OMA" id="DWGEGSL"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
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        <location>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="282" mass="32307" checksum="522138BE40B66B7F" modified="2013-05-01" version="1">MPTAIEHLGAKIYLIHTPQLHRPFLTTVPFIAGDFVSWGYRVDQHASNSPYIAEIRVREKKQHANRKGRDVSQRTKLMEIWAHEIVERKKTEREARRQNSRRGEEGGQTTDSETRNPCLHTDPRMKKTGDFVQDFLGGIVEVGNEDNLDTPPSKKTPEILPETSRIRDHVRYLYAIRYIPNAPLPDWAHPTVTYADMVVLEYRPQKSDMHDHFLRALGKAIGKDEGRMGKVETCIKTGAMRVSLWIDVGDVIGEWAMSRQGDVEDRDPVPKYERGEGPPAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">COCSADRAFT_100695</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704734.1">
        <property type="nucleotide sequence ID" value="XM_007706544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRN9"/>
    <dbReference type="GeneID" id="19129713"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_100695"/>
    <dbReference type="eggNOG" id="ENOG502S6IQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040050_0_0_1"/>
    <dbReference type="OMA" id="LFMTWLR"/>
    <dbReference type="OrthoDB" id="5377213at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="151"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="416" mass="46070" checksum="A26B76481A1BC326" modified="2013-05-01" version="1">MSARHARLHKRGHSASAAPSSLSPVADYGAFTFDRSNTPNVYKESWIEPQRPMPAAASAHPLKIKPYLRKLSSKETSGLDLSRPAAENDLTGLGILEYGAYSHSISEVNFTPINPRNRHSRSTSNQSQYSASSGPRPTPLPSIRQTPQLFSPPIAGSSPSSILGSELEGDDIMSDDEVRLKQNSYDPTRRSGSMSSAQGTSLRLHTNNSSTRLAATYSQSTASLTSPTGPPRARGDTLKSIDTTTSPSSRTSFDQAYRFIRGGRDSPVDPASRAASIRAARQKFEQEQRAKELKYEKDAHKQQERDYRKQLKKEDLQRRKSETLDRNEMNRTRTTSDDSEKTPRPSVGGRPSIGGRQYSDHRQAHSHSLPKLVTTVDPEKAAMSAVPKVSKSRAIKGRWLRFVTWLKTRLLRLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRY4</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">COCSADRAFT_100614</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59567.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007706410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRY4"/>
    <dbReference type="GeneID" id="19129710"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_100614"/>
    <dbReference type="HOGENOM" id="CLU_3147160_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="49" mass="5699" checksum="086ED9BE0F184964" modified="2013-05-01" version="1" fragment="single">NIITSLDIIYYLDNIEVISRLDKLTLTTSKDISKAKLVSKKEYKILKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS51</accession>
    <name>M2SS51_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
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            <recommendedName>
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            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">COCSADRAFT_116481</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65090.1"/>
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        <property type="nucleotide sequence ID" value="XM_007701399.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2419">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002661_0_0_1"/>
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        <property type="reaction ID" value="UER00616"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF-hand"/>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="PS_Dcarbxylase"/>
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        <property type="entry name" value="PSD-B"/>
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        <property type="entry name" value="PSD_type2_pro"/>
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        <property type="entry name" value="PS_decarb"/>
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    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
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    </dbReference>
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        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF-hand"/>
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        <property type="entry name" value="EF_HAND_1"/>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023225603" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023225602" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="45"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="265"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="378"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1043"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="859"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="917"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1004"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1004"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD65090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1087" mass="121247" checksum="56A411EE4B53B249" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSH6</accession>
    <name>M2SSH6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_175125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704276.1">
        <property type="nucleotide sequence ID" value="XM_007706086.1"/>
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    <dbReference type="AlphaFoldDB" id="M2SSH6"/>
    <dbReference type="GeneID" id="19132946"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175125"/>
    <dbReference type="eggNOG" id="ENOG502S35T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042190_1_0_1"/>
    <dbReference type="OMA" id="IENPGVY"/>
    <dbReference type="OrthoDB" id="5411678at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="391" mass="39835" checksum="D69D0680A11CB461" modified="2013-05-01" version="1">MSSNAPAKTPAPPPSSAPPSPPPSSAPAPPPAPSSAPPPAQSSAPPAPPPSSNNNAPPISTVTAAPAPTSTDVFTSVVVITSATAPGLPPQVITITSTISSPANTAAPPNGASASGGSAKPTTTGTTGLQDAQKEDSGGLSTSGKTAIAVVIPIVIVALLVLGGIFFWRKRKQRKSAEDERRKEVEEYGFNPNHDPTLPAVGGLAMAEDESGYRGWGNTTTSSNRKMSTTMTSGMTYSDSNSNPGGYAAPHSPTGIYSDAQSNDPLMDGRRQTMDSDGIGALGGAAAGATAANSANNQSGVHRGPSNASSSYSAADHSDHSGDYPGMAGNQQHDYYGNQEYYQPGPYGSNDPYGGQQQQPIIRDVSARRNTRIENPSVFPHQGNSGIAQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2STF9</accession>
    <name>M2STF9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="11">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BNA4</name>
        <name evidence="13" type="ORF">COCSADRAFT_170045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="11"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698677.1">
        <property type="nucleotide sequence ID" value="XM_007700487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STF9"/>
    <dbReference type="STRING" id="665912.M2STF9"/>
    <dbReference type="GeneID" id="19132669"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_170045"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023210_2_1_1"/>
    <dbReference type="OMA" id="REFMFIA"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="5"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD65565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="482" mass="54369" checksum="4AF14C62815A859A" modified="2013-05-01" version="1">MTQKLVVIGAGPVGSLAALYAAVRGFEVEVYELRADLREAKTTPLTLSKSINLALSERGIHSLRKTGLSDLADAVLAETYPMGGRMIHVRKNGEYVRQAQAYDARGRSLLAMDRTGLNKTLLDHLEAMPNVKLMFNHKLVGADFKKKIAWFEYRPNSPEEQGDEFELSFDLMIGADGAHSAVRYHLMKFVPMYFHQEYIDKLWCQFHVPAGPNGDFRIPPGYLHIWPQDESMFIALPNLDKTFTSTLFLTREGFEELDISGKVVEYFNEKFPGVVPDLITEDDLRQQYKANAHLPLISIKCTPYHYGDSGVILGDAAHAMVPFYGQGMNAGLEDVRVLFEFIDKYPDDRFMALSEYTKQRTPDAQAINDLALGNYREMASDVKKPLYLLRKWVEEKLYIYVPSAGWATQYSRVTFSNMRYSEVQKAAQNQAEILNGVVGVGIASILGSVFWFARSGGAHQVKMGILRSICMLAQKLQSFTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2STH5</accession>
    <name>M2STH5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_248306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704306.1">
        <property type="nucleotide sequence ID" value="XM_007706116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STH5"/>
    <dbReference type="STRING" id="665912.M2STH5"/>
    <dbReference type="GeneID" id="19135160"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_248306"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018539_3_1_1"/>
    <dbReference type="OMA" id="GNTTMYQ"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="141"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD60072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="641" mass="70833" checksum="9E2CE9F3E9FF6971" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2STW8</accession>
    <name>M2STW8_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_40171</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705440.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2STW8"/>
    <dbReference type="GeneID" id="19139663"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40171"/>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_0_0_1"/>
    <dbReference type="OMA" id="WVGVETK"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD60531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="392" mass="42008" checksum="2D7C4FFD449CD055" modified="2013-05-01" version="1">MSATAPKTLIWLDCDTGHDDAYALLLCAHDPQVELLGVSTVHGNAALDQTTYNTRAILEAVGRRDVKVYSGAAKPIARDAVHAVDIHGESGLDGVTLLPLPVEPAATDVDHLEAAYQALIATPPDTAWLVSTGTLTNIGLLFQKYPDLAGHIKGLSIMGGAVGGGFTDAPMGKVEGEGERFGNWTPYAEFNIYCDPEASHLIFSNPTLRPKTTLIPLDLTHQVLGTRKVRQTLLYGSGIWDNSSTTSKYEPTPAPLRALFTQIMSFFASTYAEIFSITQGPPLHDPLAVSAAYNPHIFDDRDGERFLVDIVTDGVHSSDKSLVGELGRTKVAKLPPGQPGCRIPRAVDLDAFWGSIESALGRADTVSALPRVEAEELERVGVFEGVGRLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU07</accession>
    <name>M2SU07_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_244321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_174784"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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            <end position="170"/>
        </location>
    </feature>
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        <location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">COCSADRAFT_345932</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD60647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31488" checksum="38233F83BD3DC5AB" modified="2013-05-01" version="1" fragment="single">SEGSSTAIVDQCYDNLLEMIRPQRQALLTGPRITIHIGNTSVADIYKRSAMAASSVLHRHFTNHPNSSEYRFSRGQIHPGAVRLLLIKWMREACNEFEAHAVPYQKTFFEDVAVLRAARLLGMERYCPHILGAYITYLKSELPSYEEIVIIEQNATSDKDPLWTTMVNHLCHERFKGLIPDAHGFEEFLETHDRLKTAMETADAFFAGYAKRLADARESERRQRRQQNEAEKRARIEREKRAVQSLKKKLDEAGSGLMTVTADEAEMLRGRTYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVR2</accession>
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        <recommendedName>
            <fullName evidence="4">Chaps-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">COCSADRAFT_174253</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ND90Pr / ATCC 201652</strain>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD61407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="256" mass="29122" checksum="B0D0FB3CDF3109D2" modified="2013-05-01" version="1">MNSTRHRLLYQLNSRWIYGKIPLLHSIVFLLQMAAVSLLTRKYNQYYAARPVLTTMITNAVLGGIADTVAQTLTAVRERAVRKKGGPGKDDFLAIEIHDLDKRNPFNENDLIPDSKKLPPPFDFERTTRFMSYGFLMSPIQHRWFRFLSATFPVTKTATWIPALKRVAFDQFLFAPAGLAAFFTFMTIAEGGGKRAVQRKFQDVYVPALKANYMVWPAVQIINFRVMPIQYQIPFVSSVGIAWTAYLSLTNSAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX49</accession>
    <name>M2SX49_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_148396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702856.1">
        <property type="nucleotide sequence ID" value="XM_007704666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX49"/>
    <dbReference type="STRING" id="665912.M2SX49"/>
    <dbReference type="GeneID" id="19131451"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_148396"/>
    <dbReference type="eggNOG" id="KOG2671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029646_3_0_1"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="178"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD61536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="482" mass="54667" checksum="F2ABBBB176F6FB00" modified="2013-05-01" version="1">MPQYLVRLAQAHESFRRAELQALADVAGITLRFVKYQEDSPYCIVELASDAAARKLIARSILSQGIYELWGEGAEYNALHESVRSLTASKWSQYETSSFRFTIEGYRGGRSTDEQREIIDSFSYMAFKGPPRMRDPDVAFRVFEDYELDAKQPKYLYYGRFIADSCRNEAKKTFDLKKRHYISTTSMDAELTLVTANIAHVAPGKVFYDPFMGTGGFPIACAHFGAVVFGSDIDGRTIRGTGGSARRGQTGKYDVVGNFKQYGIESRYLGAFVSDLTNTPLRILPTGSQNSKGYLDGIVCDPPYGIREGLRVLGSRQELLEKERKSHQDQFKEPGYIPPKRPYSFTALLDDILEFAVATLVEDGRLSMWMPTANDEDIELIIPSHPGLELTSVCVQAFNKWSRRLLTYQRRRESEMPEGALEAVKKEYEKGTRASELNDFRRKYFQGFKEFESMKKEFIRMKKENNVDGDVVVRQDKGDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXW1</accession>
    <name>M2SXW1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_233556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702926.1">
        <property type="nucleotide sequence ID" value="XM_007704736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXW1"/>
    <dbReference type="GeneID" id="19134825"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_233556"/>
    <dbReference type="HOGENOM" id="CLU_2026515_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD61632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="122" mass="13350" checksum="257BA8F942B18F63" modified="2013-05-01" version="1">MRIRPSAGLAMPHLVFLRAQYCDRLASTAWRRPKYCDRVAGGIYEPVLRTRCAKVASARGPRQPCCPFPPGGPCSLALPCTWARDHCRFATGCGPSWSSADLGASICCVMCILFSKLMVAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYT8</accession>
    <name>M2SYT8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_34281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
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            <dbReference type="Pfam" id="PF00673"/>
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            <dbReference type="EMBL" id="EMD67485.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="350" mass="38928" checksum="7C0E7A800CE0F1DD" modified="2013-05-01" version="1">MAMRDLPLRTAVALGNSARPAIRAALPALGRNASSQALAEIEDASSLQTPPPPADLVKNFDPVATSRLRRRGNKQLPPSRYQYRSPKYYRGPLHPHQPPPESDPASRLFQPGPFSLSRLEQTYQSKIASDLLTLTYQHYPPGYRAPKTEQRLREWTGDSPYFKNRPLRPPRGKGEVLRLLQEPRTFRNVPKITKVVVHSMVPEAQENSGNLHVAGMVLQAISNVRAVSHKARHNVVGWGLRKGRYVAVTSTMEREDADNFLAKLIDVVLPRIKEWKGVPGSSGDGHGNMSFGLTPDQVALFPEIEVNYDAYPPKMIPGCHITIQTDATSNKDARLLLQAIGIPFYGKLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">COCSADRAFT_289830</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYV6"/>
    <dbReference type="GeneID" id="19135966"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_289830"/>
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    <dbReference type="OMA" id="CAWVGFF"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:sucrose:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="513"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="639"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD67500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="72204" checksum="31A46C2E79B946CB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZ94</accession>
    <name>M2SZ94_COCSN</name>
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        <recommendedName>
            <fullName evidence="6">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_291210</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthioribose kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697237.1">
        <property type="nucleotide sequence ID" value="XM_007699047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZ94"/>
    <dbReference type="STRING" id="665912.M2SZ94"/>
    <dbReference type="GeneID" id="19135999"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_291210"/>
    <dbReference type="eggNOG" id="ENOG502SJ8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059226_1_0_1"/>
    <dbReference type="OMA" id="VHLICWY"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34273">
        <property type="entry name" value="METHYLTHIORIBOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34273:SF2">
        <property type="entry name" value="METHYLTHIORIBOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="363" mass="40411" checksum="FB84A88803645D51" modified="2013-05-01" version="1">MKSPCDLTTEQGLSSLLSATQSGHISVKLLSGGTANYVYRCTKQDGSTSIFKHAAPYLHSNKSFAFDPTRMDYEAEILTQLASKNKPFFADPPNTTVHAVQLLSYNKNNKLLEIEDSGTRNLKDAYTDPDLNPSQISQHLATWLAALHTSSTNTSLTLEGQDSNARNNPIGVTIYRHSYRNLHLALEQFGHDTQLAHRINENFGSLLATDDECVCHGDFWPGNVLVRSNEAQSASLTVVDWEMVRRGTSATDVGQFAAEAFLLDRFRGGRGLLAAFLRAYVAERKDGEVLGKMWLRRMVVHWGVHVAFWPTCVEWTDVAGTQKLVDIGVGVLESILQDDWEKTLESPLLEDVRDVFALILERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZQ5</accession>
    <name>M2SZQ5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_49570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701662.1">
        <property type="nucleotide sequence ID" value="XM_007703472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZQ5"/>
    <dbReference type="GeneID" id="19140258"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_49570"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_2_2_1"/>
    <dbReference type="OMA" id="XEREGRI"/>
    <dbReference type="OrthoDB" id="3790270at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="363" mass="41024" checksum="D587DF42F35A81EF" modified="2013-05-01" version="1" fragment="single">KAYDVPKSTLQTRLRGVQPRSEIASTRRKLSLIEEQSLVQWILELDRRGFPPHIIDVRRMADTLLAARGQNPPPPPIGKCWVPRFIQSQPELQTKWSRRFHSQRAQCEDPVAITAWFKLVEETRQAYGVLDQDIYNFDETGFAMGVAATSKVVTSSNRVGRAVVVQPGNREWVTAIECVNASGWSLPPFIILCGKVHQSSWYHDLPSEWTVGVSDNGWTTDELGVEWVKHFNRHTASRTAGVHRLLILDGHGSHATPEFDQYCAENKIITLCMPPHTSHLLQPLDVSCFSPLKRAYGREIEELARQGVHHVDKIDFLTIYTQIRPRVFTQQNIQAGFQATGLVPLCPKRVLSSLTVVRTPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1J7</accession>
    <name>M2T1J7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700992.1">
        <property type="nucleotide sequence ID" value="XM_007702802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1J7"/>
    <dbReference type="STRING" id="665912.M2T1J7"/>
    <dbReference type="GeneID" id="19139086"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37781"/>
    <dbReference type="eggNOG" id="ENOG502S47U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064532_0_0_1"/>
    <dbReference type="OMA" id="YSIHVMA"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026168" evidence="2">
        <location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="215"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="299" mass="32741" checksum="CBD6F6F8C8536C52" modified="2013-05-01" version="1">MRFLALLPVLCCTAALILSFLCLFAGHKKGFMEDYSLLTLNTSAIGQNLVDRVSNSDSTISNIINLIPDSITDTVTDEINERIDEFRERAGIEDWYSAHMLNYCEGQYTPDEAANATLKQDDISKNVTECSKNRAMYKFDPTDIIQRALNKSGIDITLQDLQWPEDIQDGIDALNAIMAAMFVLYVIAICLIFLTLVTSLVGILTSGRLSACLNIGLSLLAFLAIGIASGLVTAVMVKGTDVINEHGNQIGLESHYGGKFLALTWAATGLMLLAVLAWFIALCFGRSERRSRSPKKSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2T252</accession>
    <name>M2T252_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 128 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701089.1">
        <property type="nucleotide sequence ID" value="XM_007702899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T252"/>
    <dbReference type="GeneID" id="19139183"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38148"/>
    <dbReference type="eggNOG" id="ENOG502RXK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_4_0_1"/>
    <dbReference type="OMA" id="ERYAYHM"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="40"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="263" mass="28846" checksum="107D5EBB061EB8F4" modified="2013-05-01" version="1">MALAGLSALTEASPLLPRGGSKRGIAFPKQHNGVAGSQWARMMAESSKISWMYDWEAVIDGEAPDLEYVPLLHSNQEWCASTWANNVANARKNYKVSHILSFNEPDQVGGGGSNMDVATAVDTHRKLIQPLANEGLRIGSPAVTNGNEPGKGINWLKSFMNGCSDCQIDFVVAHYYAWAKPQDFKDYLNKFHDTFNKPVWVTEFGVTEGNADEFLKDVLPWLDAQPWIERYAYHMAAPSDGNQFLITADGGSLSAAGQVYAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2T279</accession>
    <name>M2T279_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_191508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T279"/>
    <dbReference type="GeneID" id="19133767"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_191508"/>
    <dbReference type="eggNOG" id="ENOG502RQQT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015848_0_0_1"/>
    <dbReference type="OMA" id="NRQPTYD"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="72963" checksum="7FC77C5B97A48B6E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2H5</accession>
    <name>M2T2H5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_339010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2H5"/>
    <dbReference type="GeneID" id="19137361"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_339010"/>
    <dbReference type="HOGENOM" id="CLU_2386000_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10889" checksum="EA553A5E84034CE2" modified="2013-05-01" version="1">MAAGRRVNSMTLLFVSHHEEYVKKMGKMGICCMEVLYNTRKGPVFFGTRTCMWFVRVIFFSFLLFACGPLVLAVLIFLCKVSFGWAYTICLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T375</accession>
    <name>M2T375_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_79823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD68900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007698196.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2T375"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_79823"/>
    <dbReference type="eggNOG" id="KOG1768">
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    <dbReference type="OMA" id="KCYCVSC"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="40S ribosomal protein S26"/>
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    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
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        <property type="entry name" value="Ribosomal_eS26"/>
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        <property type="entry name" value="Ribosomal_eS26_CS"/>
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    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD68900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="122" mass="13815" checksum="F4AC01B5423CACF7" modified="2013-05-01" version="1">MVKKRASNGRNKKGRGHVKPIRCSNCSRCTPKDKAIKRFTIRNMVESAAIRDISDASVFPEYTVPKMYLKLQYCVSCAIHGKIVRVRSREGRRNRAPPPRVRYNKDGKKINPNQAAAKTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3F4</accession>
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        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">COCSADRAFT_340659</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007696245.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19137427"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_340659"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="OMA" id="NEDMMAL"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="138"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="417" mass="46559" checksum="383C477BFD091C21" modified="2013-05-01" version="1">MVVLGYKASFEKSLDAVLSKLQRDVAWFNGDASVNFLDVETSGGDATDLSIISAIKILASSSSRGSVTSLNDIWTLCNLQSDDLKSPSHDTNIPQSQTQLSIRSHLRAKKPKVKIALSFDYDALSAFLGTREHPDNNLADYSIGVFSRRVGGRRLLRILKKYQIADKVTWFIPGHTMETFEATIKEIVQSGAEIGLHGYAHEGAYQMMPEQERNVLAKCMQVSERVTSRKVQGYRAPMYQLRETTIELLKESGFLYDSSLSHHNSQPYFTPNNPPVECIDFSKPASSWLKPRPISDMDVVLPVALHSPNSEDMMGLHHFPHVANTNGQVDACVIEQRWKNTFLWLCENSEAESDDGSFIFPLLMHPDSSGLAHAMTMADRFIGWLRSLGGSVEPHTYESIAHDVLRKKGVNNDNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3L7</accession>
    <name>M2T3L7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_329413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700662.1">
        <property type="nucleotide sequence ID" value="XM_007702472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3L7"/>
    <dbReference type="GeneID" id="19136969"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_329413"/>
    <dbReference type="eggNOG" id="ENOG502R827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1049754_0_0_1"/>
    <dbReference type="OMA" id="NKLHAGH"/>
    <dbReference type="OrthoDB" id="3784117at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="265" mass="28430" checksum="13F023D73AEF8204" modified="2013-05-01" version="1">MTYTHAETQTVWAGLTKMDIRPDLLFTAPNTTTPPAELIPDKQHDMAAITAPTSLGPVDAHATSFGGLLQKRQKRPELPTRISLPNSELDDEVLPSPPPTHAILSPLPEANKLHAGHTPLIPRALSPVHHDQEPAAPEEEAPAAEYYEPEPSMLADDQPLIGPLMLPTNPVEGASDHIALDVLDDVLEKVAKDQDRFSRLKDAPEPEVVQPDPPAAPPAVDADPGLPLSRNTSSDSRKSSNSTEVVDGVRLKTPPLNFGVPIGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3W8</accession>
    <name>M2T3W8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_206271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694530.1">
        <property type="nucleotide sequence ID" value="XM_007696340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3W8"/>
    <dbReference type="STRING" id="665912.M2T3W8"/>
    <dbReference type="GeneID" id="19134324"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_206271"/>
    <dbReference type="eggNOG" id="ENOG502S3E8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066479_0_0_1"/>
    <dbReference type="OMA" id="LGQCPLT"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24518" checksum="B17E577EA060FE65" modified="2013-05-01" version="1">MPTKLMMTFVGMDLLFAGCGGLLLGFSLISEQSMRASPTVDNVTKNLLLGQCPLTAGVVNAIFVFVTFLLSLPGLFLPNNRGWLRIQGWLVVVCATFTLGLGVAIWVETLETRRNLSALWGGESPLIQSLLQQRFDCCGYVNSTTPPFVQDSTCQNTLVAAQKGGCIGKFSSFANRYLDQIFTAAFGIVGVDVILVLCIAMVLKYRMEQERYRHIDEKNGFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4D6</accession>
    <name>M2T4D6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_32039</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694183.1">
        <property type="nucleotide sequence ID" value="XM_007695993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4D6"/>
    <dbReference type="STRING" id="665912.M2T4D6"/>
    <dbReference type="GeneID" id="19136617"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32039"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008177_0_0_1"/>
    <dbReference type="OMA" id="HDMPGLH"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
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        <property type="term" value="P:vesicle-mediated transport"/>
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    </dbReference>
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        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
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    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
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    </dbReference>
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        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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            <begin position="398"/>
            <end position="663"/>
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    </feature>
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            <end position="282"/>
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            <end position="491"/>
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        <location>
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            <end position="883"/>
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            <begin position="1"/>
            <end position="10"/>
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            <begin position="110"/>
            <end position="119"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD69295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="907" mass="98993" checksum="6C8BB7E3EB2C7C1A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4Q4</accession>
    <name>M2T4Q4_COCSN</name>
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        <recommendedName>
            <fullName evidence="7">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_32142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD69415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696023.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2T4Q4"/>
    <dbReference type="GeneID" id="19136659"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="TWIMHGC"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
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        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF32">
        <property type="entry name" value="PROTEIN (MNN4), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03790)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025609" description="LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="400"/>
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    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="192"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD69415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="400" mass="45697" checksum="B4A5E05FE396464B" modified="2013-05-01" version="1">MRLPLETLLLIVHLIYVTTAVPVPVPVARRSTSFRALRGLTPLVNSFSNGHTYKHAPTKYFYESTFNSHYDGRFASAELPFRERVWNLRLMLKTYTETMDQIGIQTWIMHGCLLGWWWNGGLMPWDKDLDFIVEEEGMQELGEWWNMTVHHFPAASLGLDDARSAESDHWASERYAAQDDESDPEDDDARSKRLAWEQEVRENGKKYLLEVNPNYTNKSTSDKHNLIDARWIDTSNGLYIDITTLHIAPLSSAQEDEFNDNDPFSLTPSFAIHPSAHEPDPYADEIQLYVKDTHAYLSSQIYPLRTSHLEKVPIKVPYAYEEVLLEEYGAEALTESWYNGYAFETERGQWVERNPTMEEARYFREKSGKTTGRSAGTGRIGHGWRGEGSLGSVEGGAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4S0</accession>
    <name>M2T4S0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_199647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700097.1">
        <property type="nucleotide sequence ID" value="XM_007701907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4S0"/>
    <dbReference type="GeneID" id="19134103"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_199647"/>
    <dbReference type="HOGENOM" id="CLU_1885556_0_0_1"/>
    <dbReference type="OMA" id="KGSIWPG"/>
    <dbReference type="OrthoDB" id="3665990at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="135" mass="15230" checksum="BB6E1FC27387A14D" modified="2013-05-01" version="1">MPTSPQTHPLLTRDHYETKNTLSIFHDESQKRGFIIVIVLSVFATVGMLALIFLLIFLKRKRDRRNKATKMDAEKGSIWPGTKKGKYQKVEDEDQKDGVWSADMELDERGAYSGAGYGEGVGKEPYRPADSHASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
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    <name>M2T5B8_COCSN</name>
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        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_357429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007702038.1"/>
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    </dbReference>
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        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="50225" checksum="1281C78C1501D116" modified="2013-05-01" version="1">MCDGFQFVGRIPYLSTEPRHLVVASEVATMNFLRLHDIPVPKIYDYSATPDNGAGTEYMFMELAHGKNLCDIWFDLSTKARITVVTKLVESESRLFSLTLSSKWVEVPIVDSACDGHFCIIPNTKLSLWHGKRLNIETDRGPYPAAALEAEAKKEISYLTKFGRPLHPFQRLHREIYGYQARSPSGHLIGNSTLVRPTMRHPDLQPNNIFASDDFSITSVIDWQHCTILPLFLQCGIPNSLQNYGDNISELLTLRGLPSNFELSENAKSHEVMLLRRRQLHFFYVVATASLNPTHHDALTDNFGTLRRKLFEHAGYPREGDIATLKNDLIYLTKKWDEVVASKSNTGDETSNPCPIAFSEDEVAECLRLNYAQLEADKSLRNCRDVIGIGTEGWVPVEQYDEIKQREQEFMAAVLEAADSEGEGQNILEHWMFDNFDEEEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6F5</accession>
    <name>M2T6F5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_36193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6F5"/>
    <dbReference type="STRING" id="665912.M2T6F5"/>
    <dbReference type="GeneID" id="19138683"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36193"/>
    <dbReference type="eggNOG" id="KOG2253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009938_0_0_1"/>
    <dbReference type="OMA" id="DGCVNKK"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RBM25"/>
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        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="136"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="5">
        <location>
            <begin position="659"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD64816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="83319" checksum="30A9C8106AEC7465" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6K1</accession>
    <name>M2T6K1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_76920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695183.1">
        <property type="nucleotide sequence ID" value="XM_007696993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6K1"/>
    <dbReference type="STRING" id="665912.M2T6K1"/>
    <dbReference type="GeneID" id="19140589"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_76920"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008871_0_1_1"/>
    <dbReference type="OMA" id="AVYSMIH"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="5">
        <location>
            <begin position="511"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="4">
        <location>
            <begin position="654"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="6">
        <location>
            <begin position="803"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD70035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="860" mass="95830" checksum="740196DDD93C05E2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6N5</accession>
    <name>M2T6N5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="3 15">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_116087</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="3 15"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699451.1">
        <property type="nucleotide sequence ID" value="XM_007701261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6N5"/>
    <dbReference type="STRING" id="665912.M2T6N5"/>
    <dbReference type="GeneID" id="19130310"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116087"/>
    <dbReference type="eggNOG" id="KOG3924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027287_2_0_1"/>
    <dbReference type="OMA" id="VQQKNYW"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 15" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="208"/>
            <end position="531"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
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        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
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        <location>
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            <end position="63"/>
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        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
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        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <begin position="371"/>
            <end position="380"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
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        <location>
            <position position="397"/>
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        <ligand>
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        <location>
            <begin position="433"/>
            <end position="434"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="531" mass="58569" checksum="CCDF68A9DE98D68E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T701</accession>
    <name>M2T701_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
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        </recommendedName>
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        <name evidence="3" type="ORF">COCSADRAFT_88447</name>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T701"/>
    <dbReference type="STRING" id="665912.M2T701"/>
    <dbReference type="GeneID" id="19141246"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_88447"/>
    <dbReference type="eggNOG" id="KOG3332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034979_0_0_1"/>
    <dbReference type="OMA" id="YVLESVN"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:GPI anchor biosynthetic process"/>
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        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
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    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
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        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="279" mass="31217" checksum="16A8661CF579D7EF" modified="2013-05-01" version="1">MNWTIWASVPLLIFAFWMYTSTLSASFPTLHNKRILLLIAHPDDEAMFFAPALLALTRPEYGNHVKILCLSSGDADGLGHVRKKELVKSGLQLGIRSEDDILVVEDKNFPDSMTVTWHPRLISNLLTTAFAPDMSSVSSKDAPQAAIDAIITFDAHGISGHPNHKSLHAGAHSFLKALMHRHSGWECPVKLYTLTTIPIFRKYFGLFDAPATIIGAMLQKKQLGGFPTPLLFASSPIGYRTAQKAMTTAHESQMRWFRWGWITLSRYMVLNDLKLEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8W1</accession>
    <name>M2T8W1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_35445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD65387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_35445"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000016934">
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="57481" checksum="2CC70EDEEDAF556A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9L3</accession>
    <name>M2T9L3_COCSN</name>
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        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_307511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698693.1">
        <property type="nucleotide sequence ID" value="XM_007700503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9L3"/>
    <dbReference type="STRING" id="665912.M2T9L3"/>
    <dbReference type="GeneID" id="19136302"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_307511"/>
    <dbReference type="eggNOG" id="ENOG502SU10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894607_0_0_1"/>
    <dbReference type="OMA" id="WQEFKDH"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="215"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="312" mass="34500" checksum="6374A4571A7631D2" modified="2013-05-01" version="1">MSYPGSLKEGDGDYLLVVSGVTRYAPYLVGWQEFKDHLRKVVKEQPGWADVYSSQGHRRGEMQGWCRLKDREDADAVFTEVYHRAKGMLVHVWETSRRGDGYRLMRCNCSTAFPEIPEGGHSTGRCGIDIARVNQLGGGRAASVEVSAPYMSAQSGYMYSTYPQLQAYSQQQQQPGYAHVPTYPAYPLSNPPVYSTTTNGIPVNIRGGAILTEARGIFIRNLSHKCTMDDLNALLLQTVGYAIDIQFIRDNRTRAFKGAATAKFASKELAQNAANTLNGTVHMGMTLHVRMDTDATVVGQTEPMVVNGSYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBA5</accession>
    <name>M2TBA5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_169112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697710.1">
        <property type="nucleotide sequence ID" value="XM_007699520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TBA5"/>
    <dbReference type="GeneID" id="19132614"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_169112"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="OMA" id="VGIANIW"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD66147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48617" checksum="C080A44F036AD601" modified="2013-05-01" version="1">MSSSHLSRLFSPHISKLPGSSPQTRLTPTKFLTKENSRNYLAYAWTARRKWTLLTVISSCQTSITFNAASYSNAIPSLNTYFGTDNAQQGITAFLISHAVGCRLWRPFSEDMGRKSVTQASLGLTNMSVLIGALSKSFSGVIGGRIMSGLLSAGCDVTMSIIEDIFDEDEQFCAVLWASLFTCLGAVLAGFARGRWNFWIQLILGVTIQLLHWLLAEEMRASVLLDREAKRQREEGNTNVCGPNYDKALMEMFQCDKWVMAMLRLYEMLIFEPIILLFTLLSGYIDTLIFSFERHSYLFQQWLFTTTSVSFILVALAASCVVGYFTFFPFISHHNTRRTKSEIVLRARLNPGPPLHWFDVVVVSVLVGIANIWLFLALLFHSVCRYTSRTLGVRKSASNPDFQDIQKPEGAVSMKGGFWDERVLYIVGLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TD31</accession>
    <name>M2TD31_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_113333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698087.1">
        <property type="nucleotide sequence ID" value="XM_007699897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TD31"/>
    <dbReference type="STRING" id="665912.M2TD31"/>
    <dbReference type="GeneID" id="19130219"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_113333"/>
    <dbReference type="eggNOG" id="KOG0278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_6_1"/>
    <dbReference type="OMA" id="DGFYGLW"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="317" mass="34717" checksum="EA92D706D5427645" modified="2013-05-01" version="1">MPETTKVVPLTCHGHSRPVPHIHFSSLLDEDQYYIISACKDNNPMLRDGITGDWIGTFLGHKGAVWQARLSSNASLAATASADFSAKVWDTHTGEALHTLAHNHIVRAVAFPNQPHPQILATGGMEKKLRIYDLSRSDATSFEIGAGVHTGTIKSIVWTSDPNVIITASEDKKIRWWDLRQESTIGEHAVEGTVGSCELDNTSSDGILSVAAGNSAYFFNSQLPGSLIKSVKTPYELASVALHNGERKFVTGGSNQNDTWVRVWDFDEEKELETNKGHHGPIWSASFSPDGKLYATGSEDGTVKLWKFTTGPYGLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TD62</accession>
    <name>M2TD62_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="14">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_113409</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="14"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698108.1">
        <property type="nucleotide sequence ID" value="XM_007699918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TD62"/>
    <dbReference type="STRING" id="665912.M2TD62"/>
    <dbReference type="GeneID" id="19130222"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_113409"/>
    <dbReference type="eggNOG" id="ENOG502QVRD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_1_1"/>
    <dbReference type="OMA" id="PGCHQLQ"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF6">
        <property type="entry name" value="ENDOGLUCANASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="15">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD66687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="245" mass="26202" checksum="316B9ADD6ABB3950" modified="2013-05-01" version="1">MKYLVPTLAFAATAAAHGYVSNATIGGKDYTFYQPYQDPYTTGVKRISRPIQGNGPVEDVTLSDLQCGGYTAGGFKGSSPAALHAEAAAGSEVKLYWTLWPESHVGPSITYMARCPDTGCDAYMPESNAVWFKVQEEGRQGTSNKWASDAIRVAGGYLSYTIPKCIPAGYYLVRHEVLALHSAYKYPGAQFYPGCHQLKVTGGGSTKPSGLVSFPGAYKGTDAGIAYNAYTAQTYPIPGPKLFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFN0</accession>
    <name>M2TFN0_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_111418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697181.1">
        <property type="nucleotide sequence ID" value="XM_007698991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFN0"/>
    <dbReference type="GeneID" id="19130152"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_111418"/>
    <dbReference type="eggNOG" id="ENOG502SYSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135732_1_0_1"/>
    <dbReference type="OMA" id="HWEVRAS"/>
    <dbReference type="OrthoDB" id="4788795at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025903" evidence="1">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="125" mass="13726" checksum="4FE0F600E72A380D" modified="2013-05-01" version="1">MHFSTPISLSILLPLLATTASAASCTIDGSAAAYHWEVRASGVYGISGWCGGLWDNLNRWGGLCNPSYPYCNGQDGEMVWRFTTSVGCMRGHVESVWWEATKNEFGAITCVDAPEKKNKREEFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2TG11</accession>
    <name>M2TG11_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_291724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697271.1">
        <property type="nucleotide sequence ID" value="XM_007699081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TG11"/>
    <dbReference type="GeneID" id="19136010"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_291724"/>
    <dbReference type="eggNOG" id="ENOG502T15E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534375_0_0_1"/>
    <dbReference type="OMA" id="AYSAGHN"/>
    <dbReference type="OrthoDB" id="3903267at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="464" mass="51884" checksum="3A2A5397F326F680" modified="2013-05-01" version="1">MVPWPSQSNSSHFDGADMGYLHNYESAPQVKHGFTSRSFQPDHFIADSVGSQYQKQDDGAWAQSEDRVSQVSYTPGQDSEDYESACEDHLPSKTTKINKDGAPRKPRQPRPKLLKWTENDWKNAVLGIVWACGEKGIQIPFEQAARVVGKNCTASALQQAVLKLRGKQVADGNRIPTLKMAWTRKNRSERSLSPIANTQSTQVQPPAKTRSRKRADSLIVKLKIARRGVDGMRLETAKQPEIKLPSDVFASAQNTTVQQPFRQTHLHSMYQPQEWTSKVENHNLNDSTNMTYLYAPAYGNLGSQAQVGHDAGKQAYMGFGFDTASPPNMNEESADSVEQRKLYNRNHVVVDDLLIDQDNFVMGTTDQLRSFEDIVTPENNPFGSGFLTDMPNQTTQVYGNPCGGNAEYSQDSNPVDRRQLESVNFSEFTDYAAYSAGHNSQEPLGDIFKTEAPEVQPYSPRYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TG64</accession>
    <name>M2TG64_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_108506</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695898.1">
        <property type="nucleotide sequence ID" value="XM_007697708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TG64"/>
    <dbReference type="SMR" id="M2TG64"/>
    <dbReference type="STRING" id="665912.M2TG64"/>
    <dbReference type="GeneID" id="19130058"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_108506"/>
    <dbReference type="eggNOG" id="KOG1458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039977_1_0_1"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="216"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD68236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="350" mass="38442" checksum="A00A2260F994E668" modified="2013-05-01" version="1">MASTTNGDSNPVAQEKINTNIITLTRFLTEEQTKVKEATGDFTLLCHALQFAFKSIAYYIRRASLINLTGLQGTSNTTGDDQKKLDVIGDELFISAMRSSGRVRLLISEEQEEAIIFDEYPNARYAVACDPIDGSSNLDAGVSVGTIFAVYKLPEGAKGTKEELLLPGTEMVASGFTMYGASAQLVITMKGGNVNGFTLDNAFGEFILTHPNMRCPKTRSIYSVNEGNSMYWEQPVKEWCDSLKNPPEGGKPYSARYIGSMVADAYRTLLYGGIFAYPADKKTPKGKLRILYECAPMAMVFENAGGLAVNSSMKRMLEVVPEHIHDRSGIFLGSEGEVQKVIDAHKKYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLG4</accession>
    <name>M2TLG4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_22138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694092.1">
        <property type="nucleotide sequence ID" value="XM_007695902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLG4"/>
    <dbReference type="GeneID" id="19134593"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_22138"/>
    <dbReference type="HOGENOM" id="CLU_1481859_0_0_1"/>
    <dbReference type="OrthoDB" id="3792140at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="182" mass="20086" checksum="B1D13409B8B57C51" modified="2013-05-01" version="1">MLLRGYYKEAISTVAPIALIAVSLNNAAIRKQAPFRFCWLDTPFQKAPATLFIALNAQSSCERIYWTEAPPAHRIQLCSVWQTTIQTNAEAIAVPCHSTESPRSDGMKGLVWGQRAISSTGSKESMLNFSRIQGTGFRDQFGDDSDDLLEFLVDHFHHDASKNLGGVEQHRLEGASQASSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2QU87</accession>
    <name>M2QU87_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_41804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705592.1">
        <property type="nucleotide sequence ID" value="XM_007707402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QU87"/>
    <dbReference type="GeneID" id="19140080"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41804"/>
    <dbReference type="eggNOG" id="ENOG502R0UD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2320193_0_0_1"/>
    <dbReference type="OMA" id="DEWMRMK"/>
    <dbReference type="OrthoDB" id="3788931at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="99" mass="11840" checksum="275B17F18E31341F" modified="2013-05-01" version="1">MVLSIRSSVDSISSRLSGEKPLPRPTYYCQMNPQEQAIWAIIGEEKYEYMRDIKGRVHRHRLTYVERAQRQRAFYDSRVGHAIVGDEWMRMKLPTRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2QVP1</accession>
    <name>M2QVP1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_41039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704837.1">
        <property type="nucleotide sequence ID" value="XM_007706647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QVP1"/>
    <dbReference type="GeneID" id="19139895"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41039"/>
    <dbReference type="eggNOG" id="ENOG502QTYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_4_1_1"/>
    <dbReference type="OMA" id="PKELVIY"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="327" mass="36811" checksum="E37FDF544EB40E2C" modified="2013-05-01" version="1">MSVQAYDPPLISTFHQADPAAHIWKHDPNTVYIYGSHDWNSTRQPPVQYDMKDYYVLTQTDYTKPAKVGPKLLDLVDIPWAKQQLWAPDAAEKDGYYYLFFPAKDKDDVFRIGVAKSDKPDGKFKPEPNPIAGTYSIDPTILADNGNYYMVWGGLWGGQLQAWTNNVLNTSQFGNISPTSGPAIGPRFAKLSANLTSLATTPKELVIYDQDGKIMQANSTRRFFEGPSLNKVGNLYVLQYSTGTQHTIEVATATKPDGPYYWKNTLLQPVKGWTTHQSIVKFKKDWLLYYADASLSGRDDLRNTKVRKVLFENGTFKLAQPQPVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZE7</accession>
    <name>M2QZE7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_125252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703791.1">
        <property type="nucleotide sequence ID" value="XM_007705601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZE7"/>
    <dbReference type="STRING" id="665912.M2QZE7"/>
    <dbReference type="GeneID" id="19130618"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_125252"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043857_3_2_1"/>
    <dbReference type="OMA" id="SSRIYGC"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="6">
        <location>
            <begin position="51"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="148" mass="17007" checksum="C7BB232841DD1F72" modified="2013-05-01" version="1">MTGGDQRPVATSDLRRRLSRPRKHHPASTGESDRLIITMGLSYNIYLNSSRIYGCKNCKTHLSNHDDILSRNFRGQHGKAYLFDSVVNVTESDPNERNMTTGRHIVRDIHCRQCKETVGWKYDKAYEASEKYKEGKFILEAELLCTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3C0</accession>
    <name>M2R3C0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_234435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702976.1">
        <property type="nucleotide sequence ID" value="XM_007704786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3C0"/>
    <dbReference type="STRING" id="665912.M2R3C0"/>
    <dbReference type="GeneID" id="19134840"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_234435"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="OMA" id="MFCEKAT"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="9">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="10">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD61694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="217" mass="24314" checksum="1D09ED646C6D370D" modified="2013-05-01" version="1">MYGEAANKLVQNAKRTLALPHLPPYASELTRSIVREVRDLDKDVSSILAPYSGSFNPSASPETACALLVNHLCMRRNKRCLLAYHRVRSDKLEEYCWEGIDVLEQQGSRDHAAEATRGSALGTGGGREESSLSPEEEEYVRQYSDLLAAYKGQWTDIDLTGSLEPPRDLFIDVRVLKDAGEIQTEYGSITLTKNSQFYVRQGDVERLIAQGYLQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3C3</accession>
    <name>M2R3C3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_344603</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702980.1">
        <property type="nucleotide sequence ID" value="XM_007704790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3C3"/>
    <dbReference type="STRING" id="665912.M2R3C3"/>
    <dbReference type="GeneID" id="19137668"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_344603"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_8_0_1"/>
    <dbReference type="OMA" id="CSVYFMP"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD61699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="954" mass="105558" checksum="60E9B747D16144C9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3D6</accession>
    <name>M2R3D6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_39421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702645.1">
        <property type="nucleotide sequence ID" value="XM_007704455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3D6"/>
    <dbReference type="STRING" id="665912.M2R3D6"/>
    <dbReference type="GeneID" id="19139493"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39421"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_0_1_1"/>
    <dbReference type="OMA" id="HTYTWLD"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36540" checksum="38B451BBBDF575A6" modified="2013-05-01" version="1">MASFFANVRQGLAGRSSKGQQGKGGSSSPTASYSASPTSQHAPNQPPMPGSPALSSNMSFEGPPSEGSVPSGSRRPPFFFREEYSNLIVKGNFMTLAAKPKLVEEGEWLAHQVVEQYRLLEQMIEVIKVVDDRTGKPICNPDVCPTMSASGHTYTWLDNNKKPIKIPAIQYINLVQKWIVGKINDPNIFPTDTTAISIGTTTYASGSLTPNSTPQPLGPTSLNQPVSQLAGREWLGKSSGFPETFEGDIKSIYRQMMRCYAHIYHGHWLEPFWNVSAYKELNTCFIHFINVGKLFNLIGDKEIEPMQPLVDLWAEKGLLPPVTAAKENAPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3M3</accession>
    <name>M2R3M3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_146876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702203.1">
        <property type="nucleotide sequence ID" value="XM_007704013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3M3"/>
    <dbReference type="STRING" id="665912.M2R3M3"/>
    <dbReference type="GeneID" id="19131391"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_146876"/>
    <dbReference type="eggNOG" id="ENOG502SIDK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045148_2_1_1"/>
    <dbReference type="OMA" id="GWETRDE"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="55"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD61804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="461" mass="51162" checksum="5227ED4CB3DF3385" modified="2013-05-01" version="1">MASLSLSLSLSLSRSLSTSATSAALAAETTPAQGSLESAGAGITGGYTGNSVPLKIIIAFFLGLALYNALELIILAFVTFQHYHGLYFWSLVISAFGIIPYSLGFIIKFFRLLDPNANVGYVAVVFLTIGWYSMVTGQSVVLWSRLHLVTNSRRTLRWTLYMIICNGVLLHSVTTVLTFGSNSNTLSPATLARFVRAYSIMEKTQMLGFFLQETILSIIYIKETIRLLRLSQSVQDDTRSFDDGATIGQLRQASVRKTMYQLLAINVLIIILDLALLAMEFANQYLIQTTLKGVVYSVKLKLEFAVLGKLIQLVRDRTESDPSLNANPFSSPAAYANHRNNSSNFQNVNCTGTCTLERRNTLTLEKSSSANTSANCPDTSRRANGPTSSPLMYDFGNQQYPDFVDPRRLNSNLTHPELQASTGAGQDGWETRDEATERRSKRRRVKRASWIDLEMDKFNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBW0</accession>
    <name>M2RBW0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_357297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700156.1">
        <property type="nucleotide sequence ID" value="XM_007701966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBW0"/>
    <dbReference type="GeneID" id="19138486"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_357297"/>
    <dbReference type="HOGENOM" id="CLU_475632_0_0_1"/>
    <dbReference type="OMA" id="RKHESNP"/>
    <dbReference type="OrthoDB" id="3800150at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="508" mass="57324" checksum="6AE4272EC8AB7018" modified="2013-05-01" version="1">MAASADRSYSPEYLERLSSPDYLAGDESSSDPQSVVEPNRLPDATALLSADEDRMDSGSSVPSQERSPVGSDSNEENPPLKRFKEGPGSYYESSDNYIPPNRLPTSLIDSDGNEEPTSSKQSKKGQTNYYESSDNHIPPNRPLANSTTNPPPKKPTQNKKPSKLAAPSKPPKKNDPTAKAPLIHQIQHHWGPNFTKSFVPKCHRPLVKSSTCPTKRKRQRPLLRKHESNPHNWNPSSLTSILRIAKLTSDKEWLHKAMRDVVRYRIRHTGNRKPQLGRSDFDVIEDMLGKGWGVEYAFGVRYKHLAKEEEREGEEEEEDVEYLFDVGPESGSDEEAESDETELRRRSKEVRRKRRGDTGSSGKGKKRQSERGDEVCASSSSSSSPEETVNPYQHAWCKSRYGMFPPLPHASSSSAHSTLRAKKPEPQGTRKRTQQSTQRGKDVRHSPEDSLFVPEGMERDEHGEFEEEEEEEEEERDYEAEIAAAEAELKLARLRVAAAKAKKLKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RDR8</accession>
    <name>M2RDR8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_170767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699477.1">
        <property type="nucleotide sequence ID" value="XM_007701287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RDR8"/>
    <dbReference type="STRING" id="665912.M2RDR8"/>
    <dbReference type="GeneID" id="19132709"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_170767"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_5_1_1"/>
    <dbReference type="OMA" id="FHDVMTR"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD64944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="204" mass="22329" checksum="82E609692320FC3C" modified="2013-05-01" version="1">MPPKRRGPPSRAPVKRPSKLAKENGLTAEQEAEIREAFGLFAVSHPDHEDSKEGVLKRGDVRRCLISLNLAPDKSEVPSILSTIDPLNTGFVSFVPFLSYTAIAIHSKDQGSDEDDEEDEYREESNAEEVKAAYRLFTHGTAGPITLAHLRRVSKELREDVPDDVLKDMILEANGGVKGQGKEAGGVSLEDFESVMKRAGLSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2RFI1</accession>
    <name>M2RFI1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="10">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="10">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MEF1</name>
        <name evidence="12" type="ORF">COCSADRAFT_169992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65514.1"/>
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        <property type="nucleotide sequence ID" value="XM_007700451.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
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    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EFG_mtEFG1_IV"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="EFG_V-like"/>
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        <property type="entry name" value="EFTu-like_2"/>
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        <property type="entry name" value="G_TR_CS"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
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        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="100"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="185"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD65514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="801" mass="89232" checksum="2AC960A3C537C29F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RI04</accession>
    <name>M2RI04_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_112772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697891.1">
        <property type="nucleotide sequence ID" value="XM_007699701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RI04"/>
    <dbReference type="STRING" id="665912.M2RI04"/>
    <dbReference type="GeneID" id="19130193"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_112772"/>
    <dbReference type="eggNOG" id="KOG4530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_2_2_1"/>
    <dbReference type="OMA" id="VPEYNYG"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="198" mass="21668" checksum="4D7CC6F8A2DD59A1" modified="2013-05-01" version="1">MSKIALITGSTRTPRVGTDVAGWVHEVIKSRPEDKLEVEPLSIADFNLPIFDEPVMPAMVPAMKQFTKDHSKKWSEAIASFQGYIFVIPEYNGSMSGATKNAIDYLYNEWPGKPVAVISYGSHGGERANKHLSESLELVMKMKVAPTKVQLAFAPGTDVFAAINDGVLGEDTKKAWTEAGAKDQILKAFGEVKEILVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2RIA3</accession>
    <name>M2RIA3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_34988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Spatafora J.W."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="25264" checksum="3E26438B0F294B04" modified="2013-05-01" version="1">MSEFAFCKSFLSALDARPVKLSSDHIADARQYPAQGAYTLPRLPHPPHPQRPNPKSTDSADASTSASTITVTLKPMKPSTPTIPLSAIDPSRTSVYDLKQQYATQASLSAAKIKILYKKKPVTDSKTLIEVIGTDAGAEVEFGVMVMAGAAAASGSPAAGGTPVTSPPAVAPPTESEKGLASAGESSADASSTTTGAVSGKDIVATDEFWGNLKTFILQRTKDAEEGERLVGVFKAAWEQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M2RM85</accession>
    <name>M2RM85_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="16">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">COCSADRAFT_168915</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="16"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697317.1">
        <property type="nucleotide sequence ID" value="XM_007699127.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2RM85"/>
    <dbReference type="GeneID" id="19132605"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_168915"/>
    <dbReference type="eggNOG" id="KOG0388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_26_0_1"/>
    <dbReference type="OMA" id="NLLGFHC"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1703"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1736"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1785"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1810"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1846"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1877"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1906"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1936"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="domain" description="DBINO" evidence="21">
        <location>
            <begin position="558"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="808"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="1379"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="378"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="683"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="756"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1564"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1603"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="626"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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        <source>
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    </evidence>
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        <source>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696197.1">
        <property type="nucleotide sequence ID" value="XM_007698007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQ01"/>
    <dbReference type="STRING" id="665912.M2RQ01"/>
    <dbReference type="GeneID" id="19138021"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_350353"/>
    <dbReference type="eggNOG" id="ENOG502SH4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="OMA" id="VWPISES"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024234" evidence="3">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD68649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="236" mass="26192" checksum="A255B7630EF61DB8" modified="2013-05-01" version="1">MKIASFVAAALASVVTAQDACKLYNYYSSNGYEILNNLWGKDTATSGSQCTYVDGVTDAGTKWHSNWTWAGAPNNVKSYVYAGRLFTKKPVSQFTNLQTEANWAYDTTNIRCNVAYDLFTAQDVNHTTSSGDYELMIWLARYDVYPIGSSQGMVTIAGRTWELFYGFNGAMKVYSFIAPSPIPHFTADVKDFFTYLTEKKNYPASTQNLITYQFGSEAFTGGPAKFSVNKWSATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQA9</accession>
    <name>M2RQA9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_134877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696284.1">
        <property type="nucleotide sequence ID" value="XM_007698094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQA9"/>
    <dbReference type="GeneID" id="19130945"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_134877"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OMA" id="YHATTCI"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="252"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD68759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="442" mass="47830" checksum="E2663BCF1F4189E2" modified="2013-05-01" version="1">MATRSETASVPPAATADDSSGIELEPSSRWNELSGNEHVLPQADGGKDAWLFLAAAFAIEIMVWGFPWSYGIFQEYYSTSKNFSGASGIPAVGTSAMGILYMSLPFTFGSLIRWPHYKRIIMICGLFLMCISLGLSSLCTTIPQLIVTQGILYGIGGAVAYSPTITFLDEWFVRRKGLAFGIMWSGTGLGGVVVPLLLQWLLNRYGFRTALRVWAIALFTITLPLTYFLKPRLPVPTNSRTKITLTFLSSKSFWILQSGNVMQALGFFIPSIYLPTYTKALGFDNTVSTVPVILINVAAVIGSITMGTIVDRTHVTTAILISTVGAVVSVFLIWGFSTSLPPLLIFCFMYGLFAGSFTNTWPGIMRTVQQNTGQMESSMVFSFLSLGRGIGNMVSGPVSEALMKVGNVGGFGLYGTQYGSLVIWTGISATLGGVSIIGRRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQE4</accession>
    <name>M2RQE4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_79408</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
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        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RQE4"/>
    <dbReference type="STRING" id="665912.M2RQE4"/>
    <dbReference type="GeneID" id="19140730"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_79408"/>
    <dbReference type="eggNOG" id="ENOG502QR9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_1_0_1"/>
    <dbReference type="OMA" id="QQQWEMY"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD68794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="695" mass="75730" checksum="2241066A27031548" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="6" type="ORF">COCSADRAFT_195220</name>
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696545.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_195220"/>
    <dbReference type="eggNOG" id="ENOG502SFKU">
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    <dbReference type="OMA" id="TICHCMS"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="116" mass="13129" checksum="3B7137450AF30476" modified="2013-05-01" version="1">MTDFKGSCHCKQTERTATLQPDHHCNTCKELSGGTYTLNQVILAKALKITKGDDLGKYTYQGASGQSVHCFYCKNCTTYVYHQQEVLQGIKDFKPLVEIFGKDLLPWEKEVANTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M2RTQ4</accession>
    <name>M2RTQ4_COCSN</name>
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            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">COCSADRAFT_194504</name>
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    <organism evidence="24 25">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705667.1">
        <property type="nucleotide sequence ID" value="XM_007707477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RTQ4"/>
    <dbReference type="SMR" id="M2RTQ4"/>
    <dbReference type="STRING" id="665912.M2RTQ4"/>
    <dbReference type="GeneID" id="19133899"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_194504"/>
    <dbReference type="eggNOG" id="KOG0539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMD58563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="392" mass="44589" checksum="94F37D2F723E61D7" modified="2013-05-01" version="1">MPGRTLPTIPTAEVRAHNTDKSCYVTIGTKVYDVTDFLDGHPGGPELILEYAGKDVEAILKDEISHAHSDSAYEILEENLVGFMATESVINGAVKSSKPADIIPLPPSQAGTQELKAMSQDGKPLYEATGMSSEEDLSKETDPNKDYKEHKFLDLNKPLFMQVWNGGFNKQFYLEQVHRPRHYKGGDSAPLFGNFLEPLSKTPWWVVPTIWWPCVAYGTAVAYGGLRSVPELAGYWIFGLCFWTIIEYVLHRGLFHLDDHLPDNRVAITLHFILHGIHHYLPMDKYRLVMPPTLFTALATPFWSVAHGIIFWNWHAAVAAFCGGVFGYTCYDMTHYFLHHQKLPSYYQQLKKYHLKHHFADYQNGFGVTSRFWDWVFGTELDMGPTKVIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2RTY8</accession>
    <name>M2RTY8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_107325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695204.1">
        <property type="nucleotide sequence ID" value="XM_007697014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RTY8"/>
    <dbReference type="GeneID" id="19130023"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_107325"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="OMA" id="NLGTHWT"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="96"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD70064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="538" mass="59356" checksum="855B05365931A42F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUI0</accession>
    <name>M2RUI0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_107692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695336.1">
        <property type="nucleotide sequence ID" value="XM_007697146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUI0"/>
    <dbReference type="STRING" id="665912.M2RUI0"/>
    <dbReference type="GeneID" id="19130036"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_107692"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071097_1_0_1"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD70234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="226" mass="25237" checksum="58743491CD55622E" modified="2013-05-01" version="1">MSGWGLGWFGGGGQTKKDGPKKAILQLRGQLEMLNKREKHLQNQMDEQDALARKYVSTNKQAAKSALRRKKQFEHSLEQTSSQIMTLEQQIYSIESANINKETLDAMKNAGAAMKQIHAGLTIDKVDDVMEGLREQHAIGEEISEAITSSIANNGIDEDELDEELAELQQEKLDEQMLNTGSVPIHDAPSSQKLPQAPNTNPKAPQRVEEDDEEEELRKLQAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZJ6</accession>
    <name>M2RZJ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_40121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703621.1">
        <property type="nucleotide sequence ID" value="XM_007705431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZJ6"/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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            <dbReference type="PubMed" id="23236275"/>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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    </evidence>
    <sequence length="417" mass="46247" checksum="FF3900405FA4F610" modified="2013-05-01" version="1">MASQAVTTALQEIETAPVSDKPSQYTALLQHIIDSSVNVAADLKAYAQTLLDDSLGIVVLRPLLAAFVDAFRTLKDPDAKIEIGERVVTLLQSKGVGQYEEQDTQIKQALADAFEENEDYRRSAQTLATINLESTQKSVTPDEKAKVWIRIVRCYLEEDDPTSAYTHLNKIKNIIFSVQDKATKVMFHLSQARILDSQRSFLDAAQAYYGISNEPLVDSEERDGFLGRAIICTVLAPAGPQRGKMLAKLYKDDRASSADDFAILEKIFLNRLLTPAEIKAFSAKLDPHHLARGSDGLTVLDKAILEHNLVGASKLYNNIGFDQLGELLGIDAEKAEDYAAKMLEQGRLAGYIDQIDRYVFFEGEASGERKTGHAERVVGKELRKWDANVTGLAEEVEKVTSMIQNQHPDFYAAQVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7L0</accession>
    <name>M2S7L0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_41871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445656">
        <property type="protein sequence ID" value="EMD58370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705799.1">
        <property type="nucleotide sequence ID" value="XM_007707609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7L0"/>
    <dbReference type="GeneID" id="19140104"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41871"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="OMA" id="TYSPFFW"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025100" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="618" mass="65858" checksum="8DEC969D9506EEF8" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7L5</accession>
    <name>M2S7L5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_359304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701351.1">
        <property type="nucleotide sequence ID" value="XM_007703161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7L5"/>
    <dbReference type="GeneID" id="19138611"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_359304"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OMA" id="PPIWKYL"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="427" mass="48925" checksum="2133D58FBB1D6A7F" modified="2013-05-01" version="1">MATSKEGKKLPTLFSTQSEEYHSQLKRSVNSVFSMSAQMQYEPIFDSVNDVFLHQTQERFSNTGKYCDFYQWLQFYTFDVIGELVYSKRHGFLESNYDIEGIVKGNSALFDYAAVVGQIPVLDKLWKKNPIKLLAARYGLIDSSYPVASFARARLAERHPSGTVFSKENLAWQRNDTNMPQDFLSKFIQAKHDRPDFFNDQLVVTMCVSMAFAGSEPAAVSMSGVFASLLRNPRCLEKVYEELDHKALQGHFKDNATGTVTWQESQELPYLDACIKEAFRLHPAPGLPFERVVPPEGAMIDGQFIKGGTIVGCNAWVIHRRTEIFGDDLDDFVPERWLVDPSKDREAEIARIKEMDYYIMSFGKGPRVCLGKHIGMMEVYKLIPAVLRRFELELEEGSREVRFRNGWFVRPVELKVKFTDRKLVKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7S2</accession>
    <name>M2S7S2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_38050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701059.1">
        <property type="nucleotide sequence ID" value="XM_007702869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7S2"/>
    <dbReference type="GeneID" id="19139153"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38050"/>
    <dbReference type="eggNOG" id="ENOG502SEY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153999_2_1_1"/>
    <dbReference type="OMA" id="WYTLNAV"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD63173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="88" mass="9963" checksum="4B06899F2E085C82" modified="2013-05-01" version="1">MGYKPFRSTYYDDRMRASPALLRARAPYLIKNTITGFAICSLVIGIYTYTINAISQDEFEDVIVPDKPLDRSAQPTTQALQQAMDARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SAT7</accession>
    <name>M2SAT7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_89350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700235.1">
        <property type="nucleotide sequence ID" value="XM_007702045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SAT7"/>
    <dbReference type="GeneID" id="19141296"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89350"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="LWNSQHH"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD64453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="328" mass="36646" checksum="E38BB4322FD976E9" modified="2013-05-01" version="1">MSLGRKVTLNTGATIPQLGFGTWQAEPGQVGAAVLEALKVGYRHLDLAKVYGNQKEIAEALKKAFGGEVPGLKREDVFITSKLWNSQHRPQDVPAALDDCLAELGLDYLDLYLVHFPVAFDERSDVHSNLFPLEGEDVKMLDEISIVDTWKAMTQLPKEKARAVGVSNHTKEHLQALIDGTGVTPAANQIERHPRLLQPELIQYCKEKNIHVTEYSAFGNNMLGIPLLVQHDTIKEVASRIGATPAQVILAWAQVGGHSVIPKSVTASRIQENFKEVELSEEDFQKVEEIGKKERRRFNIPYIANKPRWPVNIFDEPEEKEAPHKVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB23</accession>
    <name>M2SB23_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_127119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704683.1">
        <property type="nucleotide sequence ID" value="XM_007706493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SB23"/>
    <dbReference type="STRING" id="665912.M2SB23"/>
    <dbReference type="GeneID" id="19130677"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_127119"/>
    <dbReference type="eggNOG" id="KOG1273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032142_0_0_1"/>
    <dbReference type="OMA" id="DYEDDIM"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="483" mass="54677" checksum="3D77354211F0FC6B" modified="2013-05-01" version="1">MNLSLVDPFVLAQDCPDVITGRLRSGHSTSIRFSHRGDLLASGRHDGIVVIFDIETNGVARKLRGHTRQVQSLSWSTNDRYLLSAGQDWKCVLWDLKDGSRVRTVRFESAIFIAELHPKNHMLFVAALFEDQPVIVDMSEETPVKHSLSSAPHRTDIERENATEKQTAQDAKQTTTMTLFTPTGEHIIAGTNKGWLNIIDTKTHQVRYSFRATNNIIVYIRLTPSGRDVVINSSDRIVRTLHLPDLSDPKLDFDTLQLEVEHKFQDLVQRLSWNHVSFSPTGEYVTASTWMNHHIYVWERGQGSLVKILEGTKEELSVVEWHPFRPFVAAVGVDSGRVWLWSILQPQRWSALAPDFLEVEENVEYIEREDEFDIQPLEELHKRRLNQEDEEVDVLTVDPVKAGGNEFGPGVGEAEFSMPILLDIEASDSEDEVVAVGAGQFRRRTPGAAREWMNEDEVAVSGDEVRRTNGNAVQNGTKRRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB42</accession>
    <name>M2SB42_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_175554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704700.1">
        <property type="nucleotide sequence ID" value="XM_007706510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SB42"/>
    <dbReference type="STRING" id="665912.M2SB42"/>
    <dbReference type="GeneID" id="19132976"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175554"/>
    <dbReference type="eggNOG" id="ENOG502QTJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019940_4_1_1"/>
    <dbReference type="OMA" id="HEKHIWY"/>
    <dbReference type="OrthoDB" id="3828420at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="464" mass="54036" checksum="9C01391B51211F26" modified="2013-05-01" version="1">MFPFSLTLFPNWSWLCIFVVLFLFRYVRLWVNLASNWTYTPMQPVDDPTITSKDMTVIIPTVAEDLQQLKETVQSAYRLEPFELLLVTPDSRVKRVYQMVEELGSPKIIQVLSVSQANKRRQLCRAIPEVETKITLLLDDDVWLPEKFTKWILAPFEDPRVGGVGTNQQIRRFNRSNIWEFLGAIYLVRRNFDCTACNWIDGGLPCLSGRAVAYRSEILQDPNFTYGFTHETWGSDHFLNADDDNFITRWLFSHNWKIQMQNHRECEVETTLEDDSKYLRQCLRWVRSNWRSNLTSLTEGYMWMRYPWSLYAVFQTTVTQWAFLLDCALLASAYFALCETGYYPADEGQLSRADKWQRSLLWTLFIAHWVFAKTIKLVPHLLRNPGDVRFVPVSILFGYFHNLIKLYGCITVTETTWGTREGADADDNIRMLPIPPMAAITPPLTPPPGGRVLRERCAGFPMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SB81</accession>
    <name>M2SB81_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_127252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704733.1">
        <property type="nucleotide sequence ID" value="XM_007706543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SB81"/>
    <dbReference type="STRING" id="665912.M2SB81"/>
    <dbReference type="GeneID" id="19130680"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_127252"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_3_1_1"/>
    <dbReference type="OMA" id="GQGFEWA"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="174"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD59750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="609" mass="66846" checksum="622FF2A57A2C1BBE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBY1</accession>
    <name>M2SBY1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_40440</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704084.1">
        <property type="nucleotide sequence ID" value="XM_007705894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBY1"/>
    <dbReference type="GeneID" id="19139739"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40440"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_4_0_1"/>
    <dbReference type="OMA" id="NRRMYRG"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000167">
        <property type="entry name" value="Uncharacterized mitochondrial carrier C29A3.11c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="260"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD60000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39817" checksum="80A6BEF01E33D709" modified="2013-05-01" version="1">MPAQEGERPNLQRGVSSRPRDLTDVSRAVLRSEQAKRWTKRYRTEVAASSSSLLSTFAAYPLDSVKTRLQAYKFNSFVDCVRHTYKTEGFHGFYRGVWSPLASITLVRTVSFSIYQRSKYALDNWIYQTTGSSPLVIANTKDAWPTFSTVACFGLAGVNAGAAITVIACPFELTKLSAQISVLMAERSDGGGKNEAIRKSYQNLGTWKTAQNLVRHRGWSGLYSGFHLHLLRDSIGTGIYFVTYESVKQVLAKARGTSPTHPLAVVIAGGLCGLVSWACIFPIDTAKSIYQRNCLVGGKDKATRPKIQFFNRRMYRGLGVSMSRSCIVNAIFFTAFEFTKKRINSMTYDDELLRANGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBY8</accession>
    <name>M2SBY8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_315001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699383.1">
        <property type="nucleotide sequence ID" value="XM_007701193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBY8"/>
    <dbReference type="GeneID" id="19136447"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_315001"/>
    <dbReference type="HOGENOM" id="CLU_1677733_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="157" mass="17919" checksum="EA80ADB2552D351B" modified="2013-05-01" version="1">MWYSIVPKRVSPSSPSHCSTHMYRTTPVTHDKESKTNSYPMQTHHSHAASRKTYKQNLFISPSTPSPHTQCHLHLSPPPTTNLSHHVLHIPTAPHIRSDTSNFFLERRKERNHDIFCIGHQLGRGSVAPPPPALFFVSPRPRKITEKDTFFCVEVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SC88</accession>
    <name>M2SC88_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_248337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704310.1">
        <property type="nucleotide sequence ID" value="XM_007706120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SC88"/>
    <dbReference type="STRING" id="665912.M2SC88"/>
    <dbReference type="GeneID" id="19135161"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_248337"/>
    <dbReference type="eggNOG" id="KOG2689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047594_0_0_1"/>
    <dbReference type="OMA" id="AQHFPRK"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD60080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34539" checksum="0764CBC92A3E3B01" modified="2013-05-01" version="1">MASSDLDTLVDMGFDRERAELAVKVSGGLQSAIDWLETNQEKSIDEIKQAQASSSAGASDEPPALQPGEEAKSLVCDECGKKFRSVNQAQFHGEKTGHEQFSESTEEITPLTEEEKKQRLQELREKLAAKRAKMSEQDKEDQKKNEQIRMKATKESQDIREELQKKERLKEAAAKRAEKKADEEARKRVLAKLEADKQERKRKAEEEKAKRAGQAPPAPAAQAPLATSSGPSTSKPASAYTEARLALQTPSGRVMKTFPVETTLFEVAHALEQDGLSVNTFTTNFPKKTYDKTDFGMTLKEAGMVPSAALIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCD9</accession>
    <name>M2SCD9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_164265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704343.1">
        <property type="nucleotide sequence ID" value="XM_007706153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCD9"/>
    <dbReference type="GeneID" id="19132300"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164265"/>
    <dbReference type="eggNOG" id="ENOG502SHMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_14_1_1"/>
    <dbReference type="OMA" id="PRFLTYE"/>
    <dbReference type="OrthoDB" id="5391602at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF134">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="128"/>
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    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="250"/>
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        </location>
    </feature>
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        <location>
            <begin position="27"/>
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        <location>
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    </feature>
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        <location>
            <begin position="328"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD60130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="364" mass="40873" checksum="740B7C75B069E5C1" modified="2013-05-01" version="1">MNHNYSKDLMIGLAIAFAILPTFFVSLRIWAKRISKRIGWDDFLTLGALAVCLTCCFLQLATAIHGYLGAHQPLDENGQPIMDDPGLIFFEETKFAINMISIVGLGLVKSSILILYKTIFDVRKFRICVYIVLAYVVAWTISFTFSHLFTCYPITVFIEPYYGNSCVETVPMFLALLYTDVLADLAILFLPIPMVMSVRMQMKRKIAVIVMLSLGAAVCAVSITRVVATYSIAKEYIKHPDDVVYYTAPVFFWTNIELSLGLVCACLPTLRPIWFFFYPKEETRTGYGYGYGSSGRGYGSSGLHGTKNSSFSAKLARKPYQSIDEMELTTRSEEILPPPVEHDSSSSTDKHGIRKEVTIHQTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCE3</accession>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_116207</name>
    </gene>
    <organism evidence="8 9">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD64968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007701308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCE3"/>
    <dbReference type="STRING" id="665912.M2SCE3"/>
    <dbReference type="GeneID" id="19130316"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_116207"/>
    <dbReference type="eggNOG" id="KOG0321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018451_0_0_1"/>
    <dbReference type="OMA" id="RTAHNNR"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
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    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="613"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="679" mass="74312" checksum="C44D1C84FCFE05A6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SD08</accession>
    <name>M2SD08_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_141788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Han J."/>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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            <end position="158"/>
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            <end position="368"/>
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            <end position="618"/>
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        </location>
    </feature>
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        <location>
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        </location>
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            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="644"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66563.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">COCSADRAFT_220670</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
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    </comment>
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    <dbReference type="HOGENOM" id="CLU_018012_2_2_1"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016705">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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        <name evidence="9" type="ORF">COCSADRAFT_82745</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Hamelin R.C."/>
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                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
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        <property type="protein sequence ID" value="EMD67803.1"/>
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    <dbReference type="AlphaFoldDB" id="M2SKV6"/>
    <dbReference type="STRING" id="665912.M2SKV6"/>
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    <dbReference type="eggNOG" id="KOG4183">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_034953_1_0_1"/>
    <dbReference type="OMA" id="LWNHYVA"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
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                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Dhillon B."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <source>
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        </source>
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</entry>
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    <accession>M2SMQ9</accession>
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        <lineage>
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            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
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        <property type="entry name" value="MASK PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR23206:SF7">
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        <location>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700813.1">
        <property type="nucleotide sequence ID" value="XM_007702623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNA4"/>
    <dbReference type="STRING" id="665912.M2SNA4"/>
    <dbReference type="GeneID" id="19137080"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_331840"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003663_1_1_1"/>
    <dbReference type="OMA" id="TAWYSFL"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000055">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
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    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
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        <location>
            <begin position="535"/>
            <end position="728"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD63805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="803" mass="89900" checksum="4F093DC2B45917D4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNG4</accession>
    <name>M2SNG4_COCSN</name>
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        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
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    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_265142</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007707549.1"/>
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    <dbReference type="GeneID" id="19135508"/>
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    <dbReference type="eggNOG" id="KOG0350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_15_2_1"/>
    <dbReference type="OMA" id="HLEWLVI"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="192"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="526"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD58676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="706" mass="77431" checksum="DEDD2A0358933D3E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNX6</accession>
    <name>M2SNX6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_135180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Han J."/>
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                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="LaButti K."/>
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            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="376" mass="42599" checksum="D294C9A57F038A89" modified="2013-05-01" version="1">MCKFSSSALNSDTQSENATVDLEVSTAATKPSHSVHPGPELEESRRKASGSSLSVKTYSYSSPSLTIPELVRTLGIAGVSTFGRLSFRTAKRILYELRRRFEEQKLEYQAVMSVCRRQGSWRTHGSGRISKVINSKTRNSMGKATTHIRKQKEEKPSSKAKKSKAPLIRKLTIPTEHDPDALSKTFRILAFQAARLAEEAGATLSSIQHHRLRTQVKHRRSLSRARHVRRLHAPRRRKFGTKIRYHKSNVGADPTIRKLRSKRNSVPEKRKPSIKKRASRPRVRRVSIPIPIKRHESFFIGTIRYPDGARAKFKRRLPSRSHGSSARGRTRGTVLRRVPVEWRATDMAVAVKRREEARRLAATVEGWLSGGVEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPG5</accession>
    <name>M2SPG5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_264679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705711.1">
        <property type="nucleotide sequence ID" value="XM_007707521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPG5"/>
    <dbReference type="STRING" id="665912.M2SPG5"/>
    <dbReference type="GeneID" id="19135503"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_264679"/>
    <dbReference type="eggNOG" id="ENOG502S8J5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801643_0_0_1"/>
    <dbReference type="OMA" id="RAYHEFH"/>
    <dbReference type="OrthoDB" id="5397628at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025992" evidence="3">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="348" mass="39525" checksum="EA28064FE1F9495D" modified="2013-05-01" version="1">MGAILSLPFTLLNFLLPFTRAGTPLSQDLLHTAILCGTLYFAPQIAEWYNARQQEAHTTPLDQTDAHEPTNQPDNDLTNSDTQAVADPPLDERFVLQDDDEADNTPGAARPRAPTPPPPPRHQAHVEDDEHHDARDPFAPGPANPPPQPARAPPTHRTVGTKKAKSLARKDQQRAYNEWLRQEAEIRRRQEDEGREEREAALTLERERRAAAEEVIRAKEREEREALKREREREADEEAERRERVVSYVKSRIEEVGCVDLVEAAWKEGKDRVWVERLVRASGLLSQLQRDGSRVLLTGRDWLVRIDQQIMDKAYAEAERFGQEHGGKVGFEDFGSILENVVLQSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPK2</accession>
    <name>M2SPK2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_348521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD59061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705490.1">
        <property type="nucleotide sequence ID" value="XM_007707300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPK2"/>
    <dbReference type="GeneID" id="19137900"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_348521"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_1_0_1"/>
    <dbReference type="OMA" id="RIHRKAN"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD59061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37489" checksum="BB5F8FB46D587039" modified="2013-05-01" version="1">MDPQIAVNVSQLLQATGVAVLIFSRNSCYALMNEQGIPTVVIPASLLPELRKLPDDVLSRAETTEINIFDKLNLLIAKVSSRVFVGPEMCQDPKYIDTAAGYTLEFMNAVHSVKTLRLWLKPYLEPRTPEVKNLRQREKLAKKILRPLIEERIHRKANNSSWQEPDDLLTMIFAAIHTTTATATNIFYTLAATPESVPSQPNNDGIITFCALQQMEKLDSYMKEVMRVSPSFLTSFVRYVEKGFALSTGHHIPAGVMIEASAASIYKDNEFYQSPESFDGFRSLSRPTKRALNFGYGRHACPGRFFAANEIKMVLARMLLQYDVKMPDGKTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQG7</accession>
    <name>M2SQG7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pex N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_210462</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_210462"/>
    <dbReference type="eggNOG" id="KOG2879">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="79"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="415"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD69488.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="524" mass="58301" checksum="0976DEEC6146737F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR07</accession>
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            <fullName evidence="6">Mid2 domain-containing protein</fullName>
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    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_212682</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007696747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SR07"/>
    <dbReference type="STRING" id="665912.M2SR07"/>
    <dbReference type="GeneID" id="19134432"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_212682"/>
    <dbReference type="eggNOG" id="ENOG502SK6S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043314_1_0_1"/>
    <dbReference type="OMA" id="QYSAPYR"/>
    <dbReference type="OrthoDB" id="5425848at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF10">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025226" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD69678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="38001" checksum="DC814F7B941427EB" modified="2013-05-01" version="1">MHLFTMPSAMLGLAAFAYLPAALAKPYPPVHFQDLENYHNSSQSVEKRACDGVSCGYGGWLCCPSGSTCYTDAQNQAQCGGSGNASPQGTGGVWEYHTTTYVETVGLLTKTQVFSTYVPATATQTCKDSQNPCGSTCCDSGFYCLTAGQCALIAGGSSGGISPSAPLRPTGSGVVIVTYTGTPTATVPFQTPIPTGAAGNDLVPTEGQNNGLSGGAIAGIVIGVILGVLLLLLLCLFCCARALFDTLLAIFGFGKKRKHSHEETYIEEHHHSGGAAGGRWYGAGRPARPSRAGSEKHSGAKKGLGIAAGLGGLALALGLKKHQDHKADDKSTTVSGTSYMYSDYTSTSSASSSDRHTRRTRHSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRD4</accession>
    <name>M2SRD4_COCSN</name>
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        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_356026</name>
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    <organism evidence="17 18">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699403.1">
        <property type="nucleotide sequence ID" value="XM_007701213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRD4"/>
    <dbReference type="STRING" id="665912.M2SRD4"/>
    <dbReference type="GeneID" id="19138409"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_356026"/>
    <dbReference type="eggNOG" id="ENOG502QRJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_1_1_1"/>
    <dbReference type="OMA" id="WHTFVAY"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025894" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD64850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="403" mass="43856" checksum="18BDDD51B3379BA6" modified="2013-05-01" version="1">MLLTKLAQLCLIATPALSAMTKVGSVCTVTPSGSADDSGFILDAFKQCGQNGRIDITAGNFTIGKVIDVLNLKNCEINIRGKLTWTADIQYWVKNSVSVVFQQRSTAFRLGGENFSVLGHGQALFDGNGQAWYDANKNGANMAGRPISLTLWHAKNAVVDGITWRKVQFWHTFVAYSQNITMTNLDMKAVSDSQWGTVNTDGFDSWNSRDIVLKNWVVTCGDDCISIKGNSTNVYVKNATCYGSGAMVIGSMGNPPNIPETVENVIFEDIQAYSSSNAAWIKTYPGQGYVRNVTFRNFHMTNVNQPIYVTPCIYSYTGCDNSRLKISDITWQNITGTSRYNVAAAIYCSKSTPCTGLKFKDINIKPMNGGQAKILCSNLNSDSGLACTGTCPAGWKQQLSGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS68</accession>
    <name>M2SS68_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_175505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704664.1">
        <property type="nucleotide sequence ID" value="XM_007706474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS68"/>
    <dbReference type="STRING" id="665912.M2SS68"/>
    <dbReference type="GeneID" id="19132970"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175505"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_0_1"/>
    <dbReference type="OMA" id="WMIDATR"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="50002" checksum="4DDFC4E1AF388AFD" modified="2013-05-01" version="1">MNVQLVSNWAHAVQTFAVASLFVALVALILNIERRLKLWKIPKFVAFTNGVPEHNFFAQYATQLYHQAYKKFKDSIYRVAVNGEPECILLPTKLLPELKKHPDDVLNVMEAGNKTLDLNMIHCIKASLTPALGRLNHDITEEISIAFEKEIPPCKDWTNVNVHDKIANIVAEVSRRMFVGPEICRNPEYLDHAVNFTTDLNDAVFAIKRCNSWLRPFMESRLPEMKRFNDRIRRATEFFTPIILSRMKPENKSDDMMQWMLDYSMSTGKGNTMHEHVRRQLDVTFAAIHTTTTTVINCLYTLASMPEYIAPLQEEVRSVRAAHGGELSAPALQHLVKLDSVLKEIGRMFPTTVRSEAAQSQFVSSNIRDLYFGYGKHACPGRFFAANEIKIIMAQLLLDYEFKMPDYQIKRYDQITYAKFITPDASKTLLMKRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SSG1</accession>
    <name>M2SSG1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_181150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699681.1">
        <property type="nucleotide sequence ID" value="XM_007701491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SSG1"/>
    <dbReference type="STRING" id="665912.M2SSG1"/>
    <dbReference type="GeneID" id="19133288"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_181150"/>
    <dbReference type="eggNOG" id="ENOG502SHX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006237_0_0_1"/>
    <dbReference type="OMA" id="TCTMNWA"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="931" mass="103746" checksum="FBAA7E1DAA5C7923" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST50</accession>
    <name>M2ST50_COCSN</name>
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        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_189265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698606.1">
        <property type="nucleotide sequence ID" value="XM_007700416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2ST50"/>
    <dbReference type="STRING" id="665912.M2ST50"/>
    <dbReference type="GeneID" id="19133665"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_189265"/>
    <dbReference type="eggNOG" id="KOG0757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_0_1"/>
    <dbReference type="OMA" id="WVMYEQM"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="52"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="173"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="286"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD65465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="41798" checksum="BE5DA87EE49E0B79" modified="2013-05-01" version="1">MALQETSRPRGIRDSPAHPLQPLPPSSRELGEVTPPKLADGASVAKEDPKSGKSWAHFVAGGLGGMASATLTAPLDVLKTRLQSTFYQQHLAAMRAARGLPPIESMSFARSSLLHIRETGEILWQVPKAEGWRALFKGLGPNLIGVVPARAINFFAYGNGKRLISTHFNNGQEAAWVHLCSAAAAGIVTGTATNPIWLVKTRLQLDKNTHSDGRGRQYKNAFDCTMQTIRKEGVRGLYRGLTASYLGVTESTLQWMLYEQMKLSLARREERVLASGKPPTIWDQTVAWTGKLTAAGSAKFVAALITYPHEVVRTRLRQAPMADGRQKYTGLVQCFRLIWKEEGMAALYGGLVPHMFRVVPSAAIMFGTYEGVLKLLGESSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2SU03</accession>
    <name>M2SU03_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_244270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
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                <person name="Han J."/>
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                <person name="Condon B.J."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
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                <person name="Wang R."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698198.1">
        <property type="nucleotide sequence ID" value="XM_007700008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWX2"/>
    <dbReference type="STRING" id="665912.M2SWX2"/>
    <dbReference type="GeneID" id="19132642"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_169691"/>
    <dbReference type="eggNOG" id="KOG3418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067359_0_1_1"/>
    <dbReference type="OMA" id="NQWFFTK"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD66805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="135" mass="15594" checksum="61783AC832D3F6F1" modified="2013-05-01" version="1">MKFLKVGRVVIITRGRYAGKKCVIISPLDNGTKSHPFPHALVAGIETYPSKVTRRMSKTKQAKKSKVKPFVKQVNYTHIMPTRYTIELENLKGVISADTFKEVSQREEAKKTVKKAFEERYQSGKNRWFFTPLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXP6</accession>
    <name>M2SXP6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">COCSADRAFT_96761</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702991.1">
        <property type="nucleotide sequence ID" value="XM_007704801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXP6"/>
    <dbReference type="STRING" id="665912.M2SXP6"/>
    <dbReference type="GeneID" id="19141698"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_96761"/>
    <dbReference type="eggNOG" id="KOG2616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015170_1_0_1"/>
    <dbReference type="OMA" id="NFERYLY"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="108"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD61716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="545" mass="60765" checksum="BC363070052A2F5B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2SY31</accession>
    <name>M2SY31_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_343418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702240.1">
        <property type="nucleotide sequence ID" value="XM_007704050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SY31"/>
    <dbReference type="GeneID" id="19137599"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_343418"/>
    <dbReference type="HOGENOM" id="CLU_839390_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="331" mass="34944" checksum="DC4F66F734204DEC" modified="2013-05-01" version="1">MAHVVSSRLELPSFAMATATRYNVDGFNLAHASSSCMATVVNGLADGWLVTADLALQLRPEPRPSNGQPGTDAPRSGPRHLSPLARLPARLLVCSFIHQMETETAPSDRDFPSRPSSALVCLLLLLVDWLLLSSATANLSCSEILPVCVGVGAASPTLPPTMESAPRYSATPACTASFSPQALARHVHCTSHPAMSTTTATTTSAPTTVSNPLIDRQAPHLHASRLPPCTTQLSNLTIPPSGHSPPPLCHRMCWLQPPHAPHSHATLIGASGLANLHMTILPIGYRCFNLHDSSMAATDRRQVIAPHDLFSLDLGGGTIMIAQADDTAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZC3</accession>
    <name>M2SZC3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_291544</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697263.1">
        <property type="nucleotide sequence ID" value="XM_007699073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZC3"/>
    <dbReference type="STRING" id="665912.M2SZC3"/>
    <dbReference type="GeneID" id="19136006"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_291544"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043308_1_0_1"/>
    <dbReference type="OMA" id="CNIAKDS"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="178"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="339"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD67660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="404" mass="44928" checksum="88918847218294AA" modified="2013-05-01" version="1">MTETQPAQTLLATDKSLESSASNELVHTTEQTIITTNAEGKKVKKIIRRKRRPARPQIDPAEIKTQETPQTGTIYNVWYNKWSGGDREDKYLSQTPAQGRCNIARDSGYTKADKTPGAYFCLFFARGTCPKGVDCEYLHRLPTVTDIFPSNVDCFGRDKHADYRDDMGGVGTFQRQNRTLYIGRIHPTDDIEEVVARHMQEWGEIERTRVLTARGVAFVTYMNEANSQFAKEAMDHQSFDHNEILNVRWATVDPNPQAAKREARRIEEQAAEAIRKALPAAYVAELEGRDPEGKKRRKVEGSFGLQGYEAPDDVWYAKEKGEWEATKQLQAGGAGDRMAIESGDNAYQDMNPGLDTGAAQQQQQNSGILSGSTLAALKGFKATPSNKRPTPAAGPLVDYGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZV3</accession>
    <name>M2SZV3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_182646</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701718.1">
        <property type="nucleotide sequence ID" value="XM_007703528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZV3"/>
    <dbReference type="STRING" id="665912.M2SZV3"/>
    <dbReference type="GeneID" id="19133369"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182646"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_0_1"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="12">
        <location>
            <begin position="37"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="295"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD62312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="349" mass="36575" checksum="393AC39D6DB4D2EF" modified="2013-05-01" version="1">MFSAVRQCALRTARTRLRQSQPVAVPQYSAFARLASTLAVLEQKDGKIVSQSLAAITAGTKIGGSITAFVAGNGVKAVAEEAAKSKGVEKVLYVENGAYDKSLPENYAPLLVENIKKGGYTHVIAGHSAFGKNIMPRVSALLDSQQISDITGIESEDTFVRPIYAGNAIMTVQSSDSTKVITVRGTAFPAPEAEGGNATVEEGVDPKAECPTEWISEDLQKSDRPDLGSADKVVSGGRGLKSKEEFDKLMPPLADALGAAIGASRAAVDSGFADNSLQVGQTGKNVAPQLYLCAGISGAIQHLAGMKDSKVIAAINKDPEAPIFQVADVGLVGDLFEKVPELTEKLKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2T002</accession>
    <name>M2T002_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_221704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701866.1">
        <property type="nucleotide sequence ID" value="XM_007703676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T002"/>
    <dbReference type="GeneID" id="19134600"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_221704"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_1"/>
    <dbReference type="OMA" id="MLVHNAG"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD62516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41073" checksum="85EBC9156F9B279D" modified="2013-05-01" version="1">MAPLSLYLDFYSSYLKCSLNFVLARLYTQNPPQRDLTGQTAIVTGANSGIGLCIAIRLARQGATVYLACRNQAKGDEAVDYIKSQLGSSGKTANIFCWTLDVSDMSSVRTFCSRWRTQGTPIDVLVHNAGIPDVTSSQRRYDEKGLDMIYVTNLLGSFLMTSLLEPLLSPASRTVFTSSISSYLARDTVLLPRPPRPDYQNSNALARLWHRARAALGLRDSAALVYGQTKAHQILLATLLQNHFDASYPENKRTVHAFSPGFTQSPLFTKYDMSWRTLLYDPAFSFLYYTETVVATETDEGAKTGAWLAACGGEEGVEGGNYWELMKSEVSVIEYWRGKMGEEKFKGVARGIWKVWEEDAGCEWDIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2T118</accession>
    <name>M2T118_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_349630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695890.1">
        <property type="nucleotide sequence ID" value="XM_007697700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T118"/>
    <dbReference type="GeneID" id="19137971"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_349630"/>
    <dbReference type="eggNOG" id="ENOG502S5CN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415666_0_0_1"/>
    <dbReference type="OMA" id="TRAVDTK"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025527" evidence="2">
        <location>
            <begin position="18"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="651" mass="71385" checksum="F887C2C358732AAD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2T191</accession>
    <name>M2T191_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_191238</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701260.1">
        <property type="nucleotide sequence ID" value="XM_007703070.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2T191"/>
    <dbReference type="GeneID" id="19133752"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_191238"/>
    <dbReference type="eggNOG" id="KOG0736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_0_2_1"/>
    <dbReference type="OMA" id="KIMLCEP"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="785"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1063"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="285"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1328"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2T2I0</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>heme</name>
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    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
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    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
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    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23038" checksum="3C804C9320F5CFAC" modified="2013-05-01" version="1">MALSLATIHTTSDLLNQTLKRLANDSDLVSELRKEVVQVLSTDDLKKIALANLKLMDSTIKQTQMMNPIAMRRITKEKVVLPTRLIFPNGQYISIDGNNMFDADIYLDPYKFDVYQYYHVQEDSKTAIKAHLISTCSENLSLGHGIHSCPGCFFVANKMKIALSSLAQPYNMFGDTVIFDPSNKLRYRRRQEELDLDSLHFD</sequence>
</entry>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_327892"/>
    <dbReference type="HOGENOM" id="CLU_1427863_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="190" mass="21294" checksum="AF09FBBA92985A21" modified="2013-05-01" version="1">MYRDMYLSKYYSIRPIRSPTATSLLLPSIPPILCWRNPSWLCHWLAYFPPVPAILTTSGRVNAVHRPHRTDLQTVASVPCTCCLGPNSPPALSYLGPLRIPMDHGPLKLSSTHKQFRLEPSASSSFELALWPLSWLCCVLCPPAHAWLLGCCQSARVCCGVRAVQRETGNKQKSMQMARPRMVLTRALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2T310</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37216</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2305851_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="100" mass="11262" checksum="5E860050FE1279DB" modified="2013-05-01" version="1">MSEAWMRIRAVTPIPIMPAQPASCTDSTCSTDSIDSTYPTDSTGSTRCTSSHQDQDSRGEKKVRWGVVHTREFEPPPEDNDEQPSNKVDAKPRQQQQQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3B1</accession>
    <name>M2T3B1_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_90802</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700739.1">
        <property type="nucleotide sequence ID" value="XM_007702549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3B1"/>
    <dbReference type="STRING" id="665912.M2T3B1"/>
    <dbReference type="GeneID" id="19141368"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90802"/>
    <dbReference type="eggNOG" id="KOG2103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005034_0_1_1"/>
    <dbReference type="OMA" id="SWAEVYH"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026203" description="ER membrane protein complex subunit 1" evidence="13">
        <location>
            <begin position="19"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="15">
        <location>
            <begin position="18"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="14">
        <location>
            <begin position="710"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD63706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="937" mass="101847" checksum="744AC0D10AC026E1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4F7</accession>
    <name>M2T4F7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_160372</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700004.1">
        <property type="nucleotide sequence ID" value="XM_007701814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4F7"/>
    <dbReference type="STRING" id="665912.M2T4F7"/>
    <dbReference type="GeneID" id="19132035"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_160372"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD64126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="475" mass="52435" checksum="E2B15F66636CDE8A" modified="2013-05-01" version="1">MEDERAATNLGPDVDQGIAEESPSVPKQPKRRFVGRKTAEKTSGQPVDPNSNIEDSSTIQVAMPRRTARALNAIPDDIVHDKDINDAIALLPPNYNFEIHKCIHRIRTSGAKSIALQFPEGLLLFATTISDILTRFCPDTSTLIMGDVTYGACCIDDYTARALGCDLLIHYAHSCLIPVAVTKIATLYIFVSITIDTQHLINTITDNFAMGKTIALVGTIQFNATIHGIVPILRKEGYNPFVPQIAPLSKGEILGCTSPSMAMKAGELDGRGREQQVPDLILYLGDGRFHLESAMIANPQLPAYRYDPYSRRLTHEVYEHESLYSLRRSAILTARKARTWGIILGSLGRQGNPHTLTLIENELSKQDIKCVSLLMSEIFPGKLAMMGDVEAWVQIACPRLSIDWGYAFPRPLLSPYEALVAMGVREAPWLDEDEGQRASGGKERRNLYPMDFYASEGLGRTTVEHVKAAEVAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4W7</accession>
    <name>M2T4W7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_323605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700131.1">
        <property type="nucleotide sequence ID" value="XM_007701941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4W7"/>
    <dbReference type="STRING" id="665912.M2T4W7"/>
    <dbReference type="GeneID" id="19136741"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_323605"/>
    <dbReference type="eggNOG" id="ENOG502STZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020367_0_0_1"/>
    <dbReference type="OMA" id="AFLHYPQ"/>
    <dbReference type="OrthoDB" id="5362630at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="87628" checksum="BE1E0287436EA91C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5T1</accession>
    <name>M2T5T1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type 2A phosphatase-associated protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_186617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695018.1">
        <property type="nucleotide sequence ID" value="XM_007696828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5T1"/>
    <dbReference type="STRING" id="665912.M2T5T1"/>
    <dbReference type="GeneID" id="19133570"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_186617"/>
    <dbReference type="eggNOG" id="KOG2830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041824_2_0_1"/>
    <dbReference type="OMA" id="EYELCEA"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40169" checksum="55EDA3C74EAD5B38" modified="2013-05-01" version="1">MSEEPLSLRGLFSKAEKAREELSSSYEPNSPTFQEKLGATIATYEECLKIAEQVSLFSPNESLEDISSTDLQYLAINYHLAELVQRISNTDVSLRKSNLLRARGYYERFLKLLDSYDMLGKADTKLLEAYNENKNNFSTANTRDASARRDAKIARFKEEKELKRKLEYLRQNPKLAEQDEQVVRDLHLTDLAFMIHQTFASLESMAQELHIISLAPPAPPPGQDQQAPDARQDSRGKDGYSERLDGQYAGLRYSGPILSSDGKPMRPFTLLDSRQSLKKGVFRPDHNLPTMTIDEYLEEERKRGGIIEGGGPQSGIQPEPNEDDLDAADAETMKQRAWDEYVEANPKGSGNTLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T6F7</accession>
    <name>M2T6F7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF572 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_37117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699874.1">
        <property type="nucleotide sequence ID" value="XM_007701684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T6F7"/>
    <dbReference type="STRING" id="665912.M2T6F7"/>
    <dbReference type="GeneID" id="19138902"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37117"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050402_0_0_1"/>
    <dbReference type="OMA" id="YDDAMYK"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD64547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39512" checksum="12D896EBED28943E" modified="2013-05-01" version="1">MGRYYPPDASNPPSFNNNSHPLGKRANKISQGILTVRFELPFAVWCDHCTPSAIIGQGVRFNAEKKKIGNYYSTPIWSFRMKHSACGGWWEIQTDPKNSEYKVVEGAQRRDYGPGDKGPEAEGELKFLTDEERQRRREDAFASLEGKLEDKNAEKKHKERVEELYDQSEVWRDPYDVNARLRRDFRAKRKVWKKEEMQKEGIQAKFSLGLDIADETEADRMRAGLIDFGASASGAQELEQQSWKPIFEEKDISKAVEPTSKTRKLKAELAAEKSRQGLQQTLIGNTRAAIDPFLSKDSGPASRINLGILKRKRDAPAEEEVSTVSPVETGDATLTKKPALLSTLVGYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7D4</accession>
    <name>M2T7D4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_46425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699203.1">
        <property type="nucleotide sequence ID" value="XM_007701013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7D4"/>
    <dbReference type="STRING" id="665912.M2T7D4"/>
    <dbReference type="GeneID" id="19140214"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_46425"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195566_0_1_1"/>
    <dbReference type="OMA" id="GCATEWF"/>
    <dbReference type="OrthoDB" id="3656564at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD65126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="50" mass="5478" checksum="80293CAFEF21DE6D" modified="2013-05-01" version="1" fragment="single">EPGYCFCGTPDTNDMIACDGKGCATEWFHFTCVGLTPETVPKGKWICDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7H3</accession>
    <name>M2T7H3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_315974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7H3"/>
    <dbReference type="GeneID" id="19136470"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_315974"/>
    <dbReference type="HOGENOM" id="CLU_2015073_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="123" mass="14503" checksum="6E529C230A57475D" modified="2013-05-01" version="1">MGKYVCVFHLQRTTITNFLFSFPFCISHLFHFMYIYIYIRLGNSTHSTLDASTHGPYTACRPDYTQRAQKITNQPLHYLLNRKKECRIYTYKHVDVAGVSKEWTAEQAHGKKNPEKKFVFAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2T8X9</accession>
    <name>M2T8X9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_159335</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700589.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2T8X9"/>
    <dbReference type="GeneID" id="19131954"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159335"/>
    <dbReference type="eggNOG" id="KOG2021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004414_0_1_1"/>
    <dbReference type="OMA" id="HEMFLFG"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="103"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="343"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD65706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115894" checksum="6771F170FBDB4482" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAZ6</accession>
    <name>M2TAZ6_COCSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_353612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697899.1">
        <property type="nucleotide sequence ID" value="XM_007699709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAZ6"/>
    <dbReference type="GeneID" id="19138242"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_353612"/>
    <dbReference type="HOGENOM" id="CLU_113784_0_0_1"/>
    <dbReference type="OMA" id="FYCENDV"/>
    <dbReference type="OrthoDB" id="3676096at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="185" mass="20615" checksum="9EB23BE69D3E7EB0" modified="2013-05-01" version="1">MAPSPTPSVPSQETKRAMSSQDTIPDDTLYQGYQNCLSVRDNVVYPAVDRAEPASASKQSGNKSKEQPGKFTSRETKEAASHTNASKAILPTDRVALKNYIERKPEESHTEVVDFLEELKNIKGQLEHTLGNVEDLVSRLQEATEQHTHKTLPMSGKLVRWADSTGTYSAKHDIHRARKKARGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2TD94</accession>
    <name>M2TD94_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_34065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696531.1">
        <property type="nucleotide sequence ID" value="XM_007698341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TD94"/>
    <dbReference type="STRING" id="665912.M2TD94"/>
    <dbReference type="GeneID" id="19137426"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34065"/>
    <dbReference type="eggNOG" id="ENOG502TBTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072561_1_0_1"/>
    <dbReference type="OMA" id="FIVPEWM"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD67211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="209" mass="22906" checksum="67AA370F8BDAA223" modified="2013-05-01" version="1">MVESIPNDIFQFSTVAALKAGFNQGQPRTSDLTSHGSDGIGVYEDGNLMMLKSGQAFVITKDGKAKPAPANARLPLALVTVYEPNFRIKIPSITIDGLEELTSSNDLGPTKGVNTLMPFRIFGRFESIEFENGPGRNAIDGVIFGFIVPEWMKAISGPRIHAHFLDTNEEVGGRVTDFQMSDQALLDFAKCGRFHLGFPQGEEWENVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2TE10</accession>
    <name>M2TE10_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_289619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697127.1">
        <property type="nucleotide sequence ID" value="XM_007698937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TE10"/>
    <dbReference type="GeneID" id="19135960"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_289619"/>
    <dbReference type="HOGENOM" id="CLU_2249902_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026352" evidence="2">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="104" mass="11823" checksum="D35B1749475749EC" modified="2013-05-01" version="1">MLTSFVVLFTLSFLIAVSFLCIHPRSHSNVILMRKVGMLTITTSEVLFRKEIDRVKKEPRRSEPGDNPKREDRPGKQKSRVEESGLWDPSTLTCHAVVGEQCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFI6</accession>
    <name>M2TFI6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trafficking protein particle complex subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_34300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696586.1">
        <property type="nucleotide sequence ID" value="XM_007698396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFI6"/>
    <dbReference type="STRING" id="665912.M2TFI6"/>
    <dbReference type="GeneID" id="19137575"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34300"/>
    <dbReference type="eggNOG" id="KOG3316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076409_0_1_1"/>
    <dbReference type="OMA" id="CKEFWTA"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD67502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="27794" checksum="914412D7F3151204" modified="2013-05-01" version="1">MAQANPSVSSETSPPYVDPTFSLVNTSCLDLLLIELVPMAYRITADLAAREEEWIHGAASAASPSARPKQLAGSPGNDAASTVAARTEGGGHVGVAGTVDEEESREAVFHRLEALGYRVGLGVVERFSRDAPRPTTPLDCIKFLCKDLWTLLFRKQIDNLKTNHRGIYVLTDNTFKPLGRMSFDTKKYDASMQAALVAQTGDPALGREANSQARVQPFLYFPAGLIRGCLAALGIQASVTAESVALPGATFQIRTVGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2TFQ6</accession>
    <name>M2TFQ6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_268534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695780.1">
        <property type="nucleotide sequence ID" value="XM_007697590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TFQ6"/>
    <dbReference type="GeneID" id="19135570"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_268534"/>
    <dbReference type="HOGENOM" id="CLU_1834998_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="140" mass="15762" checksum="8905CC81C5E26165" modified="2013-05-01" version="1">MIHDSVRIDCHNRSPHTTTASLTLATPIQTLNLPSRRTFALITCQVPFLSPLLPHSPLFPSSPHFPRHGTPTAQKNHPPTTYLRTWLVSTYPTSPPHKQLSRTYTRTTRGVTEPNPRVPPFPFPEHERSSKPFSDVGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2THI6</accession>
    <name>M2THI6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_275710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696239.1">
        <property type="nucleotide sequence ID" value="XM_007698049.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2THI6"/>
    <dbReference type="GeneID" id="19135707"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_275710"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="OMA" id="AWTDFFI"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1347"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1399"/>
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                <person name="Henrissat B."/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD68981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="556" mass="62865" checksum="E2494967274F6E3D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ93</accession>
    <name>M2TJ93_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_187637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696299.1">
        <property type="nucleotide sequence ID" value="XM_007698109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ93"/>
    <dbReference type="GeneID" id="19133596"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_187637"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_2_1_1"/>
    <dbReference type="OMA" id="EFHTHLM"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="155"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="432" mass="50549" checksum="BBE10FAAA5C94AC2" modified="2013-05-01" version="1">MIPKGYRLSFPHLVFYVSTFIITTQLYFIWGQSKLNYIDFAHRRILGDWTFDADVHANVHTLSQDQCDSAFPKLYHSLDESVRLRQGRKVHAQDIEIEKGRCMLRVLIYEGELFVVDAGMPEKCYVTNGNERERILGTLAQMDRAVTSASTSDPAIPNIEFSLSLDDLPRRSRKDGTFFGYTRKDTPEYRDIWMMPNYAYWAWNYTHAPSWNSIRKEIEQKEKDLPWDKKDPRVVWRGKIKMAKLRKELVKVSEGKEWSDIKPVVINNASDPHTKDVMNLRDFCSYKYTVQTEGTSYSGRLKYLQLCRSAMITHPLEWQEFHTHLMRLAGPEVNYIEASENFGNLESAMEYYREHDNEAEQIAKNSYETFTRRYLTPAAVTCYWRRLFWSWASVQGFDPLLYVPDKDGKMAMRGTPWTAFAANWPKDPAAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKF5</accession>
    <name>M2TKF5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="4">3.4.14.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dipeptidyl peptidase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">COCSADRAFT_32329</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="4"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694263.1">
        <property type="nucleotide sequence ID" value="XM_007696073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKF5"/>
    <dbReference type="STRING" id="665912.M2TKF5"/>
    <dbReference type="GeneID" id="19136733"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32329"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_0_2_1"/>
    <dbReference type="OMA" id="YTSTEHH"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF162">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026568" description="dipeptidyl-peptidase IV" evidence="16">
        <location>
            <begin position="17"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="18">
        <location>
            <begin position="102"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="17">
        <location>
            <begin position="553"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMD69646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="782" mass="87474" checksum="A7FCAB463A4C679F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M2TKZ1</accession>
    <name>M2TKZ1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">COCSADRAFT_195178</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694700.1">
        <property type="nucleotide sequence ID" value="XM_007696510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TKZ1"/>
    <dbReference type="STRING" id="665912.M2TKZ1"/>
    <dbReference type="GeneID" id="19133923"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_195178"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="66"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD69352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="462" mass="49941" checksum="A61676BC259DB53B" modified="2013-05-01" version="1">MTTVPVSEVKSTHDRSSRTAAHSHIKGLGLSSDGRATPSAGGFIGQAAAREACGLVVDLVKAKKMSGRAVLLAGGPGTGKTALALAISQELGTKVPFCPIVGSEIYSAEVKKTEALMENFRRAIGLRVKETKEVYEGEVTELTPEEAENPLGGYGRTISHLLITLKSAKGTKKLRLDPSIYEAIQKERVRLGDVIYIEANTGAVKRVGRSDAYATEFDLEAEEYVPIPKGDVHKKKEIVQDVTLHDLDVANARPQGGQDIMSMMGQLMKPKKTEITEKLRLEINKVVNRYIDQGIADLVPGVLFIDEVHMLDLEAFTFLNRALESPLSPLVILASNRGNTHIRGGTNLPPSAHGIPTDLLARLLIVPTHPYSPAEISSIITTRVTTEKLNISPAAKDKVSSLGEKISLRYALQLLAPASVLAEVNGRENKQIEVEDVEECQDLFLDARRSAEALGQASGYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLN6</accession>
    <name>M2TLN6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_186815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695211.1">
        <property type="nucleotide sequence ID" value="XM_007697021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLN6"/>
    <dbReference type="GeneID" id="19133576"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_186815"/>
    <dbReference type="HOGENOM" id="CLU_1855102_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD70071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="138" mass="14954" checksum="F3CFC1A38DFED1BE" modified="2013-05-01" version="1">MLLPPPVKLLGPLQRPTAPFLPYAGPVPDLDSPMFRRSTLPSPLYRLQACQSILSAGLAAALPITCPRRPDGLVFFHVHRDPNHRQVTALSPSATRPDAPSATMACPLLLRGLAFDARTRANHRVPASSLTSAYQSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2QT21</accession>
    <name>M2QT21_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_185894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445657">
        <property type="protein sequence ID" value="EMD58324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705985.1">
        <property type="nucleotide sequence ID" value="XM_007707795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QT21"/>
    <dbReference type="STRING" id="665912.M2QT21"/>
    <dbReference type="GeneID" id="19133527"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_185894"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032917_1_1_1"/>
    <dbReference type="OMA" id="DFMIEDC"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016487305" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="27"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="330" mass="38359" checksum="69A6E71BF7C1F159" modified="2013-05-01" version="1">MKVRKGMQWPGVAVVMVALLCGVARASMGDHLPEFKQCVRVCMEANCGEGKGVDIPFHRRLLLWDCPSECDYTCQHIITQQRLARDPPYMQPVYQFHGKWPFYRFLGVQEPFSVIFSLFNYLAHDWGMARLRERIPASYPLRKYYLMFGYVGLASWTFSMIFHTRDTGLTEKLDYFAAGANVLYGLYYAPIRVFRLDRPEPRKQSLLRLWTGLCIVLYTLHVLYLSLWSWDYTYNMAANVVVGIVSNILWSGFSYVQYKKIGRTWAVWPGICVAWIVMAMSLELLDFPPWKGMIDAHSLWHLGTVVPTIVWYNFLLRDAQEDIAGTRLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2QUD6</accession>
    <name>M2QUD6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_129471</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705787.1">
        <property type="nucleotide sequence ID" value="XM_007707597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QUD6"/>
    <dbReference type="STRING" id="665912.M2QUD6"/>
    <dbReference type="MEROPS" id="C12.009"/>
    <dbReference type="GeneID" id="19130748"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_129471"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018316_1_0_1"/>
    <dbReference type="OMA" id="YIQYEIQ"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="13">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD58754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="311" mass="35419" checksum="712BC71F9ED94732" modified="2013-05-01" version="1">MSGGWNTIESDAGVFTYLIEKLGVKDVQFEELTTLEASDLQNLGTIYGVIFLFKYPTGEKPSDVPKDGTYDYEAASSIFFPAQTIQNACGTQAIVSLLLNREEEIDIGKELREFKEFAGDFPPDLRGETLSNSDLIRETHNSFARSSPFIDETQRTATEDDDVFHFIAYTSINNKLYELDGLQPAPISHGPCTSSEFPQKIIPVLQRRIARYPATEIRFNLMACCRDLRIRAREIGDEEELEEQEDKRARWLWENSLRRHNFVGFVGELLKSVVRAKLDQGGDAYDKWVEEAKGRSAKRREDLRKQGIAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2QUH1</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_153357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="69"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58789.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
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    </evidence>
    <sequence length="149" mass="16079" checksum="1D2A21C868226171" modified="2013-05-01" version="1">MSRKVLTYGGLTALGGATYYLYNAGGDPKLAEKKVEHDAATAARRLRGDYPGQDKEAKKAAEEGYEAVRASAQQYADQAKGEANRLEKKFDAYSADAKKQYEHAKALAEQELHQAGKQVNAAANKFDAVVEDKAAKATGWFGGWFGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_101661</name>
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    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="22"/>
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    </feature>
    <feature type="chain" id="PRO_5004024325" description="Ecp2 effector protein domain-containing protein" evidence="1">
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            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24605" checksum="14E7A2963E9B19A2" modified="2013-05-01" version="1">MLTHLPTMLFLLAAAIATPAFAGIQQSDFSGIGHIYVLKSDNWQTATPKATVGCLDTNGKFISDKSPFNKCGVFSRLEDFPYTLSTSKGNCTFEDDKQEKNTDSYYGKTDSAWSCGERVADIYDQLYTINGFSYVFLCFGDVACFYDAKHTPNPHEILPLWQYRWGSQQMGITPGHIQLQLMWKKIGELPGQSEVSEFLGPRVQVKEGSQMPLMGKKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2QX11</accession>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_251577</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704613.1">
        <property type="nucleotide sequence ID" value="XM_007706423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QX11"/>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
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                <person name="Salamov A.A."/>
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                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702707.1">
        <property type="nucleotide sequence ID" value="XM_007704517.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2R249"/>
    <dbReference type="GeneID" id="19141690"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_96610"/>
    <dbReference type="eggNOG" id="KOG4645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001999_2_0_1"/>
    <dbReference type="OMA" id="PPCVDEN"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1044"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1326"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1329"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1073"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMD61329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1350" mass="151953" checksum="9E83FED74E6787C4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M2R349</accession>
    <name>M2R349_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_148556</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702924.1">
        <property type="nucleotide sequence ID" value="XM_007704734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R349"/>
    <dbReference type="STRING" id="665912.M2R349"/>
    <dbReference type="GeneID" id="19131453"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_148556"/>
    <dbReference type="eggNOG" id="KOG0343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_1_1"/>
    <dbReference type="OMA" id="YDKMFER"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="80"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="282"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="684"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD61629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="813" mass="91919" checksum="7DF2B0B1D8E53AE8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2R717</accession>
    <name>M2R717_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_37699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700962.1">
        <property type="nucleotide sequence ID" value="XM_007702772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R717"/>
    <dbReference type="STRING" id="665912.M2R717"/>
    <dbReference type="GeneID" id="19139056"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37699"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OMA" id="DEKWARN"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD62789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="363" mass="39255" checksum="9A51BFB14E30B0B4" modified="2013-05-01" version="1">MTSPAEFTGWLGHDKSAAQGKMTWSSFKPKPFNDIDVDIKVSHCGICGSDIHTLRSGWGTTHYPTCVGHEIVGHVVRIGEKVKNLNLGDRVGVGAQAFSCLRDNCEECSAGIEQHCTKMVSTYNSKYPDGSWSMGGYADYVRVPAHFAIRIPAGLRSEDAAPMMCGGITVYAPLKNNGAGPGKRVGIIGIGGLGHFGLLFAKALGCQEVVAISRKRNKVEDAKAMGATNYIATSEDEKWARKHSRSLDLIISTVSSPDMPLESYLRLLRTGGSFIQVGAPEDKLPPITAFGLIGKGCKIGGSQIGSPRDIEEMLKFAAEKGVKPWVQKRNMKDANQAVVDMEDGHARYRYVLVNADHGDRAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2R740</accession>
    <name>M2R740_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_334193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Salamov A."/>
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                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_37149"/>
    <dbReference type="eggNOG" id="ENOG502R909">
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012903974" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18533" checksum="C77BD155B285C40B" modified="2013-05-01" version="1">MRVALLAAIVPVALAGWNPKSCNGAGGCTQVGYSNSGPFVCPDGSRLNLPSFAGDNLNAGNGNADPVSKEDFPKSCTSGAVPPADATFIKVKSKNNQTMFFYVTGKCDTPKPEAFNCYSKNPNPSVHTFCSMYDTKGALCKENNAAGYCERWGYSTVNPQCAFWKPGGPDLPNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">COCSADRAFT_159375</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007700623.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19131958"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_159375"/>
    <dbReference type="HOGENOM" id="CLU_2037870_0_0_1"/>
    <dbReference type="OrthoDB" id="940393at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD65754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="121" mass="13633" checksum="D6FF315828DEC998" modified="2013-05-01" version="1">MAVKRFFDSSFDEMCKHLTAFELERRSAPIVAQLERRTTYTSTAKPKSATYQTREYRLPTHEVRSDPAPTPPRASSSVPRPASKTPVLERQATPGNCYYCGKPGHFASDCTVPRVREIEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RHG7</accession>
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            <fullName evidence="4">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="4" type="ORF">COCSADRAFT_197687</name>
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    <organism evidence="4 5">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007699544.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2RHG7"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_197687"/>
    <dbReference type="eggNOG" id="ENOG502QQBW">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_033072_0_0_1"/>
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    <dbReference type="OrthoDB" id="5282002at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Mss51_Znf"/>
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    </dbReference>
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    </dbReference>
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            <begin position="115"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="244"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD66179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="512" mass="59357" checksum="2748EA92924DBD4A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2RI24</accession>
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        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_353631</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <position position="60"/>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    <dbReference type="STRING" id="665912.M2RST9"/>
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            <end position="139"/>
        </location>
    </feature>
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        <location>
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            <end position="234"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="53"/>
        </location>
    </feature>
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        <location>
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            <end position="497"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="561"/>
        </location>
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            <end position="492"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
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    <dbReference type="PANTHER" id="PTHR10552:SF6">
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    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="244" mass="27379" checksum="E2DA6ED42674383C" modified="2013-05-01" version="1">MRLTTDLINNSLSFINCLTERELDLRGHKISAIENMGAARDNDAIDLTDNDIGQLGNFPLQPRLRTLLLAQNRVSNIQPSLSSSIPNLRTLVLTKNRIAELADLDPLAGFKSLTYLSLMGNPVTSKENYRYWVIWRCPSVRFLDFTKVRDVERKKAQELFGSVDEPTELANQISNNKSKGFVVPTFANGHDSSKERIYTDDERKRMRAAILNASSLAEMAQLEKDFAEGRIPAHILEGGGPMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2RW46</accession>
    <name>M2RW46_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_30749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704818.1">
        <property type="nucleotide sequence ID" value="XM_007706628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RW46"/>
    <dbReference type="GeneID" id="19136301"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_30749"/>
    <dbReference type="HOGENOM" id="CLU_2291472_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="101" mass="11344" checksum="7D609E83887BA4DA" modified="2013-05-01" version="1">MTINTPQFDFATLGLPIRSRTNNASGDRGGRRGGGRGGGHRRRRRHKQPSKRKYRFQAQVFFDAAVAAAARDTTDSLSTDTAPRTRSRARSLSPQDFYYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2RWA0</accession>
    <name>M2RWA0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_101523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705074.1">
        <property type="nucleotide sequence ID" value="XM_007706884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RWA0"/>
    <dbReference type="STRING" id="665912.M2RWA0"/>
    <dbReference type="GeneID" id="19129749"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_101523"/>
    <dbReference type="eggNOG" id="ENOG502SUDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633321_0_0_1"/>
    <dbReference type="OMA" id="HDFLFAT"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="477" mass="54007" checksum="7A1D6A5632EE6D55" modified="2013-05-01" version="1">MMSATPRPKRKAPKADSGINGLIATCNKNDRFELLESATVFPGDLDNPIHLVFSKLDSVEPMKQMLQLASHFLTHDTLLSFFIPLLYGHELKGVINGAYRPYLSNPLVSASGEKYRLYLAGVRDALECLSHSVSFHFVSPVKRVYARTLREDGPSTHSTECHSLFQRKCSCKIELADYFKSYYTSGEYAAASPCAQFRHDFLFATTLVHEVVHAVGVLRRGNLDEPYIRADCPDTEWGYGWEHFMFGCVINPQDRSKPGTYLLMRKVWADPKTAEEAGGKEYSDVSMSYIAQWFRKDTWDIVRKRGPAAITAPITHFKIQSSNKLGAWVVKSDCPEIIDDLIELQEQWGRRAVTPDPVLGSPTTRNGRVRCAKILWQFMTPEQLQKPNVPIPVRAPQNIRSPLACFHDHPRSQIGKCEHMHKALPFNKEDTTLYKTLDSDCRPIRKRRAGLAEECSLAKKVRKLETGVTLNSHRPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXK1</accession>
    <name>M2RXK1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_254143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704760.1">
        <property type="nucleotide sequence ID" value="XM_007706570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXK1"/>
    <dbReference type="GeneID" id="19135279"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_254143"/>
    <dbReference type="HOGENOM" id="CLU_2831041_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="66" mass="7172" checksum="60BEE0C68BA2BF39" modified="2013-05-01" version="1">MAPSPTCPLPSAKPINHPNQACWPFRPHPLESTALSPPHRKGSTWLVSPCPSYQTSLPLPMCVISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZA2</accession>
    <name>M2RZA2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tafazzin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_184193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703202.1">
        <property type="nucleotide sequence ID" value="XM_007705012.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2S0P0"/>
    <dbReference type="GeneID" id="19131471"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_148995"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_4_1_1"/>
    <dbReference type="OMA" id="SMYIGWC"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000032">
        <property type="entry name" value="Protein kinase rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058681">
        <property type="entry name" value="HEAT_MEC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25385">
        <property type="entry name" value="HEAT_MEC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="24">
        <location>
            <begin position="1484"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="23">
        <location>
            <begin position="2174"/>
            <end position="2483"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="25">
        <location>
            <begin position="2478"/>
            <end position="2510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EMD60813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2510" mass="283053" checksum="7141117415D83882" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2S1V9</accession>
    <name>M2S1V9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_184070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703503.1">
        <property type="nucleotide sequence ID" value="XM_007705313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S1V9"/>
    <dbReference type="GeneID" id="19133442"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_184070"/>
    <dbReference type="HOGENOM" id="CLU_906161_0_0_1"/>
    <dbReference type="OMA" id="CKIERQF"/>
    <dbReference type="OrthoDB" id="3695197at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="307" mass="34838" checksum="565F90A178D9180D" modified="2013-05-01" version="1">MERVRKICTLCKIERQFEHSTRRDISCPIPRPSRGHTNPHAQKGRKIFTHNTIRTNTPLKKRNTLRKKNRSAAMAKDRSATRQSTKEDTEVAKSAWLRTWLNKLPITTCPKSPTTPPSSTSPSPRKATSVDLSRIIPFRRTEEPPNAQPTNTRSPITHRTRIPQATKSSSTPNHSRHLSLSKKPMHKINTTTTTPSTPTKLQKQAPAPSRPKSTTTTTTTILRPSTTLAPDSNPITKRPQTHNPDPHPEQPKGSVVGDRRNSTAYLTITAAAGEEEEEELEMSETRRALWEYWNVQCRFLVEEWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2S265</accession>
    <name>M2S265_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_192284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702690.1">
        <property type="nucleotide sequence ID" value="XM_007704500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S265"/>
    <dbReference type="GeneID" id="19133798"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_192284"/>
    <dbReference type="HOGENOM" id="CLU_088990_0_0_1"/>
    <dbReference type="OMA" id="ISAPGHW"/>
    <dbReference type="OrthoDB" id="10455873at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="273" mass="29648" checksum="2AA21885467E2E4B" modified="2013-05-01" version="1">MAGPLSLLSGAPVIIIRKEGADRPSVASMVNLSTHLSATSHSPRCQPAVTLHQKTVGAILRTIGGCCINWNFLVLPPRHHQHVSKFLLETFASPPPLPSSKEGAAFCSLVAPQHAALHSKKTLPALRADYARAQTAAVIVCKVRCNRKERKDCSPSPPPSSLPLWPLSDNSRANRFRRLGRQLRQLLTRSRLSHYSQSEVRDTPSTIPKASNVSRTKLCANRARALRIILPPRALGQALGRNELLMNDSAPKKPISAPGHWLSHASTASDPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2S377</accession>
    <name>M2S377_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_233344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702916.1">
        <property type="nucleotide sequence ID" value="XM_007704726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S377"/>
    <dbReference type="GeneID" id="19134822"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_233344"/>
    <dbReference type="HOGENOM" id="CLU_2891945_0_0_1"/>
    <dbReference type="OMA" id="LNCQTSF"/>
    <dbReference type="OrthoDB" id="10316911at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024662" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="62" mass="6903" checksum="4F253554CEB17F4F" modified="2013-05-01" version="1">MAVRFHLSFLISFLPAYLSLTCQTSFSPNVSTYYALPPSTRLNSPSVSFSFLLRIHSTSVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2S3I8</accession>
    <name>M2S3I8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_39444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702650.1">
        <property type="nucleotide sequence ID" value="XM_007704460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S3I8"/>
    <dbReference type="STRING" id="665912.M2S3I8"/>
    <dbReference type="GeneID" id="19139498"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39444"/>
    <dbReference type="eggNOG" id="KOG3048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_0_2_1"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD61743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17542" checksum="6C0014F7851F2F80" modified="2013-05-01" version="1">MASKQGGQPGQIEITSLPVPRLQELKTQLDAELTHLSNSFQSLRTAQSKFKDCLTSITTGLTASTTNKPLLVPLTSSLYVPGKLTDHEHVLVDVGTGFFVEKDIPGAKDFYERKVKDLGESLKDLEQVVQGKAQNVRMVEEVIRLKVMSAQESKGEEQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6H0</accession>
    <name>M2S6H0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IDI-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701659.1">
        <property type="nucleotide sequence ID" value="XM_007703469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S6H0"/>
    <dbReference type="GeneID" id="19139293"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38604"/>
    <dbReference type="eggNOG" id="ENOG502SVWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113390_2_0_1"/>
    <dbReference type="OMA" id="CWRNCDG"/>
    <dbReference type="OrthoDB" id="3660930at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024714" description="IDI-2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19500" checksum="3B3F02A079C272F7" modified="2013-05-01" version="1">MKLLSILLGLAATGALCSPTTSAVEATVEDCGELGVMEWDLASLPEGTDVSALRKCKKHPSELGIASPLYDPASETEVTNSSKRGELLDEVATLAKRGVCSKGGRGSGYDYDYGCDNGWCWRNCDGPFVNADVGLKKTWCWLAYESGNGGWTPCGRWQDCEWSYNNKAAKCGKGDCKACGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2S714</accession>
    <name>M2S714_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_37822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701005.1">
        <property type="nucleotide sequence ID" value="XM_007702815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S714"/>
    <dbReference type="STRING" id="665912.M2S714"/>
    <dbReference type="GeneID" id="19139099"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37822"/>
    <dbReference type="eggNOG" id="KOG2875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027543_1_1_1"/>
    <dbReference type="OMA" id="GYAQEYL"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="12">
        <location>
            <begin position="143"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD62938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="407" mass="45921" checksum="6886B1AAEEC60B06" modified="2013-05-01" version="1">MALRAAEWHKLPTSLTELCIDTTLRCGQSFRWRKSAEGEWSAALHGRILSLRQDPQYLHYRVTYPSITTTLPTPPLSNAPSVAPEEDDTLALVNHYFNLSPNLGHLYDQWAASDANFRKRAPKFTGIRILRQDAWEALIGFICSSNNNISRISGMVHNLCLHYGPLIGHIDEVPYHDFPTPVALSGPDVEAHLMKLGFGYRAKYIAKTARIVSEDKGLKWLEDLSNPEYPQFGVEEKPAGDMLEGGREGYRKAHEELLALHGVGPKVADCVCLFGLGWSESVPVDTHVWQIAQRDYRFGKGKHSSLTAATYVAIGNLFRKLWGKEAGWAHSVLFTADLKAFSERVIAKVEVKEEEVVIKKEDEETVMETAVKEVTKRKRIKKEPLLDEGPIVQVKQEPTRRSKRQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7A5</accession>
    <name>M2S7A5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_336405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701278.1">
        <property type="nucleotide sequence ID" value="XM_007703088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7A5"/>
    <dbReference type="STRING" id="665912.M2S7A5"/>
    <dbReference type="ESTHER" id="cocsn-m2s7a5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="19137242"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_336405"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_14_4_1"/>
    <dbReference type="OMA" id="WKEAFEP"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="55"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="559" mass="62554" checksum="1D853EC269BAFDC0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M2S954</accession>
    <name>M2S954_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase PKS5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PKS5</name>
        <name evidence="13" type="ORF">COCSADRAFT_358400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700863.1">
        <property type="nucleotide sequence ID" value="XM_007702673.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2S954"/>
    <dbReference type="GeneID" id="19138558"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_358400"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="OMA" id="FSIPICA"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="5"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="911"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2396"/>
            <end position="2473"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="911"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="943"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD63878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2484" mass="268455" checksum="FE65A878B23088AA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBH9</accession>
    <name>M2SBH9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_40335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704046.1">
        <property type="nucleotide sequence ID" value="XM_007705856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SBH9"/>
    <dbReference type="STRING" id="665912.M2SBH9"/>
    <dbReference type="GeneID" id="19139701"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40335"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OMA" id="VIGPCGR"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD59855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="552" mass="60222" checksum="3BC4997DA364E29C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCQ7</accession>
    <name>M2SCQ7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cellobiose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_40684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704151.1">
        <property type="nucleotide sequence ID" value="XM_007705961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCQ7"/>
    <dbReference type="GeneID" id="19139806"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40684"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_1_1"/>
    <dbReference type="OMA" id="AHMSGSC"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024891" evidence="5">
        <location>
            <begin position="22"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD60260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="638" mass="69334" checksum="E17AE2711164ABF5" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2SE37</accession>
    <name>M2SE37_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_193357</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704000.1">
        <property type="nucleotide sequence ID" value="XM_007705810.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SE37"/>
    <dbReference type="GeneID" id="19133847"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_193357"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001837_2_1_1"/>
    <dbReference type="OMA" id="YCCPEKE"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025530" description="chitinase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="15">
        <location>
            <begin position="168"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="230"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1822"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD60720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1867" mass="206848" checksum="E5F70DABA92EA580" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2SER8</accession>
    <name>M2SER8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_237666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703315.1">
        <property type="nucleotide sequence ID" value="XM_007705125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SER8"/>
    <dbReference type="GeneID" id="19134913"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_237666"/>
    <dbReference type="HOGENOM" id="CLU_956473_0_0_1"/>
    <dbReference type="OrthoDB" id="3690352at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="291" mass="31906" checksum="970A2037095C1288" modified="2013-05-01" version="1">MGAISQHARPIQQHSRCTDRPSISVFSPVGNARPFIPERTRTRTRTRRRNRPGLISLERPQAGLVCNAAQQGRPVEWPSDCHCVRFPVMRGSLSAQLHSLNAFMRRLAPVTACDSLRSSHALLTPLGARSTLLVPPWHPNPALPVKHQRQRIPRLPSPDCRLKILLATCLLTRSEAFVDLWPVLADTCPPLPTPSKAAIAPDTVVTTPSKLDLSYHAIGAFCASLPCDASPYLSQQTTYSRVPLPHHGGGSSVCVCVWPDFCLGCSSNMIPESLMVTWRDQHATVSDTPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFF3</accession>
    <name>M2SFF3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_97372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703467.1">
        <property type="nucleotide sequence ID" value="XM_007705277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SFF3"/>
    <dbReference type="STRING" id="665912.M2SFF3"/>
    <dbReference type="GeneID" id="19141731"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_97372"/>
    <dbReference type="eggNOG" id="KOG3471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027280_4_0_1"/>
    <dbReference type="OMA" id="KGFIIIE"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="405"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD61155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="482" mass="53785" checksum="9455BE7F680E8ABD" modified="2013-05-01" version="1">MSASSSAQALEYLEGLPLATHKKLYEQPSTVLAVFRCMLPHLAKSIVMAMLYMPTPFPAADLDTWFKPTARKEKERATFTLDRLHIITSARQDNGTLSWTLNPGFQRSLRNAIEGSGTHRSFGVPATKEESGKRVSIEFLDEYSRSQWEGILYYLVSGAAGLSKDSISRAEVGPGTKKLLHTGDLVRTIHGSPRITKDGFSFVLQETNAQVWSLLIVYLKMTNELGMSETEVLSFLFMLGSLELGQDYSTSTLSATQLQMLEDLSAMGLVYRSERNARTFYPTRLATTLTSDSGSAMSASSKDIAQASTSTTGPPTAANKGFIIIETNYRLYAYTNSLIQIAILSLFTKLQHRFPNLVSGKLTKESVHKAVQAGITSAQIISYLTTYAHPQMQKTVPYIPPTVMDQIRLWEYEGERVETTTGYLMREFGSDAEYRDVLNYASALGVLVWQNDANRCFFVSHVEQISAYLRKKKENRENARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2SFL0</accession>
    <name>M2SFL0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_170433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD66033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_170433"/>
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    <dbReference type="OMA" id="WGRQSPQ"/>
    <dbReference type="OrthoDB" id="3781481at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="163" mass="18615" checksum="D1C530B662A501BB" modified="2013-05-01" version="1">MASPPRSPTIPDHVLRIYEEQYITEPLLAALLRLQNQREATDNTEAPFKQVPCNETPKPSWGRQSPQLTPTPSPSPSLKTSHRQLQSFLTPPDTSPLRKDPASASPNKPAAARRRPRHQQVSQTPKQPFHTMLLRSRARMGRAQERRFFELDASGRRLRRIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2SGP3</accession>
    <name>M2SGP3_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_84863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697897.1">
        <property type="nucleotide sequence ID" value="XM_007699707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SGP3"/>
    <dbReference type="GeneID" id="19141028"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_84863"/>
    <dbReference type="HOGENOM" id="CLU_3001946_0_0_1"/>
    <dbReference type="OrthoDB" id="3695090at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="57" mass="6969" checksum="BA1FF696E24D1F47" modified="2013-05-01" version="1" fragment="single">LKEALLYEQKIENRTQLGIMQQPGDFHNGASFWSPRKIRETRELYKKKQRDQERLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHC6</accession>
    <name>M2SHC6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_113164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698045.1">
        <property type="nucleotide sequence ID" value="XM_007699855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SHC6"/>
    <dbReference type="STRING" id="665912.M2SHC6"/>
    <dbReference type="GeneID" id="19130208"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_113164"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OMA" id="YDDCPAI"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="17"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD66588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="355" mass="38408" checksum="CC8AEB7EE61D3CA6" modified="2013-05-01" version="1">MSSTLEQKTMRAQQYDARDNKLHLNEVSIPQPREHELLIKMQCASLCHSDVMLFEPNEQGLILGKNPVTIGHEGSGKVVATGSGEVAKQFKEGDAVGFLCAVDCCFECYSCKNVSNIWCSTGQTKIQGFSADGYFAEYAVVDAREAIVLPENLDPKTSAPLFCAGVTAYHGIADCELPAGSWLAVIGCGGLGHMGIQYAKAMGHKVIGIDITDAAVEEAKSCGADYTFNSMTDQDYKKKILELTGGGVHAAVNFTASKKSYDDCPAIVKPGEGMIMVVGIPQKPLEFNGLDIAMGRYKVKGSNNGTCYNMREVIEFSAKHNIKAHLTTFPLEEVPKMVELMNSHQAKGRMGVIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SIY6</accession>
    <name>M2SIY6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_34011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696517.1">
        <property type="nucleotide sequence ID" value="XM_007698327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SIY6"/>
    <dbReference type="GeneID" id="19137405"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34011"/>
    <dbReference type="eggNOG" id="ENOG502QQW7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_1_0_1"/>
    <dbReference type="OMA" id="IDDLPSC"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="336" mass="36245" checksum="D5EBEF3EF6AD64F1" modified="2013-05-01" version="1">MPFNTELTRALGIRVPVVQGGMQWVGYAELASAVSNAGGLGILTALTQPTPEDLRKEIRRCRTMTKKPFGVNLTLLPSMVPPDYGAYARVIIEEKVNIVETAGNSPGPVIRQLKAAGTIILHKCTTIRHAQSAVKLGVDFLSIDGFECAGHVGETDITNFILLSRARQSLGVPFIASGGFADGQGLAAALALGACGINMGTRFMCTVEAPIHQNIKQAIVDAQETDTTLVLRRWKNTSRLFANKVALQAVDVEKTSPTGKFEEVAEFVSGKRGRQVFLNGDKDFGVWTAGQVIGLIHDIPTNEELINRIEREAVETMKKSQSLFVAEDASIAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2SK28</accession>
    <name>M2SK28_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_71870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701980.1">
        <property type="nucleotide sequence ID" value="XM_007703790.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SK28"/>
    <dbReference type="STRING" id="665912.M2SK28"/>
    <dbReference type="GeneID" id="19140485"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_71870"/>
    <dbReference type="eggNOG" id="ENOG502S1UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017096_2_0_1"/>
    <dbReference type="OMA" id="FKRANMG"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="513" mass="55393" checksum="EFB8C4716F9A54DA" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2SK60</accession>
    <name>M2SK60_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_290402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697190.1">
        <property type="nucleotide sequence ID" value="XM_007699000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SK60"/>
    <dbReference type="ESTHER" id="cocca-w6y5d2">
        <property type="family name" value="Glucuronoyl_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="19135980"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_290402"/>
    <dbReference type="eggNOG" id="ENOG502QS8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028869_1_1_1"/>
    <dbReference type="OMA" id="EQPWLGD"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025075" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="9">
        <location>
            <begin position="97"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="390" mass="41142" checksum="AD8BE1E9BE6C9C67" modified="2013-05-01" version="1">MKYLIALSLLSSAVLATPLLEQRQEAACAVPSTFPSTANSKLPNPFKFFDGRSVVTKEDFACKNKEVSAALQNQELGDFPKKPSTVTASFSGSSLSITSSEGGKSVSFSVSIKKPSGSGPFPAIIAYGAPSIPIPSQVATITFNNDEIAQQQSQSSRGKGKFYDLYGSSHSAGALTAWAWGVDRIIDALEATPGAGIDPKRVGVTGCSRNGKGAFVAAALVNRIALGLPQESGSGGAACWRISDSEKAKGKNIQTSSQIVTENVWFSPRFNAFSTRSNTLATDHHQLAGMVAPRGLLVIENEIDWLGPVATTACMKAGRLIYRALGVPDNMGFTGSGNHNHCQFPSNQQADLTAFINKFLLNQSANTNIEKGPSGADVATYIDWTAPTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2SK89</accession>
    <name>M2SK89_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_162294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702030.1">
        <property type="nucleotide sequence ID" value="XM_007703840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SK89"/>
    <dbReference type="GeneID" id="19132167"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_162294"/>
    <dbReference type="HOGENOM" id="CLU_1124430_0_0_1"/>
    <dbReference type="OrthoDB" id="3542716at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="247" mass="27642" checksum="9215B668460E74F4" modified="2013-05-01" version="1">MVVVKSSNEEVELTSVHKFVLLEQTDGLCTPYNIHSKEVYHLSLYRDMTTSNCKRLAAWNQLACQYAYQAHKKPETGKTKRLHSARDMKKAVLPPNTHSENESDATSTEDMSENNTSYPSEMADVPSDIKKVSTFVPLENKELQAFADAAKKENEPFTQAQANAMIKEAQVAWSNAQHLNGHHVHLLSQGMREAGLTSVHAHLKAFVLEGSYQLTKISGHENVTVEKLSAIALQAEETVQRVLSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKA8</accession>
    <name>M2SKA8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase PKS3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PKS3</name>
        <name evidence="12" type="ORF">COCSADRAFT_343166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702043.1">
        <property type="nucleotide sequence ID" value="XM_007703853.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SKA8"/>
    <dbReference type="GeneID" id="19137586"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_343166"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_5_1"/>
    <dbReference type="OMA" id="NYGPEFQ"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="32"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="970"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2492"/>
            <end position="2568"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1118"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1002"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD62755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="2590" mass="283623" checksum="19FBC68AECB0E0B2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2SKG6</accession>
    <name>M2SKG6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-actinin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_82283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD67648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699063.1"/>
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    <dbReference type="GeneID" id="19140884"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005217_0_2_1"/>
    <dbReference type="OMA" id="QQRWITV"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD67648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="73513" checksum="C6E15D1CA53C3E54" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMA4</accession>
    <name>M2SMA4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TFIID-31kDa-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_54721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445658">
        <property type="protein sequence ID" value="EMD58276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706017.1">
        <property type="nucleotide sequence ID" value="XM_007707827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMA4"/>
    <dbReference type="STRING" id="665912.M2SMA4"/>
    <dbReference type="GeneID" id="19140312"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_54721"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068315_0_1_1"/>
    <dbReference type="OMA" id="WNMKDEW"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000069">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD58276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22196" checksum="77CF769C35ED59D7" modified="2013-05-01" version="1" fragment="single">MASPAAENVPNGISTPPATANAPTLSPPTQPPPASQPSQASNGASTNPTASMNAAFPSSSLQDNGTSKRPRDARLIHLILANMGVHAYTERVPLQLLDFAYRYTSSILSDALSYEPPLPTTSASKKRSGPNAESGEDGVSLNALRTAVGARAASTFQGTLGKEFMSEVALERNRIALPRVDREFGIRLPPERYCFTGVGWDVKGAWEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMC9</accession>
    <name>M2SMC9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_165704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="KB445657">
        <property type="protein sequence ID" value="EMD58301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705972.1">
        <property type="nucleotide sequence ID" value="XM_007707782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMC9"/>
    <dbReference type="STRING" id="665912.M2SMC9"/>
    <dbReference type="GeneID" id="19132399"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_165704"/>
    <dbReference type="eggNOG" id="KOG1906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013572_2_0_1"/>
    <dbReference type="OMA" id="IPEHHLG"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="323"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="522"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="642" mass="71227" checksum="B42504ED7858EDB8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SMF8</accession>
    <name>M2SMF8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_118397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="4">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="1180" mass="132015" checksum="A24897D80449F685" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700788.1">
        <property type="nucleotide sequence ID" value="XM_007702598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SN72"/>
    <dbReference type="GeneID" id="19131303"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_144159"/>
    <dbReference type="eggNOG" id="ENOG502SNAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_25_4_1"/>
    <dbReference type="OMA" id="WMLAMME"/>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="58"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD63770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="387" mass="42735" checksum="1473192270F3699E" modified="2013-05-01" version="1">MPGTYLNPNGSGSSGVLPPLEVLAKWPAPNYDDPITRPKVVPALAGVLGTIMIIVVAARTWARFFVQRNGGLDDWIILLAMIPTIGFTIVVYIATEVYGFDRHMWDVTPNLYVPERKIVFAVYLLYILAGGLIKISILLFYRRLDARCIPSTFRIATWLSIAIITIFITAFTIILFTACNPLAAFWYQFDAVHQLAGYKYHCWVNEEADIMAASIISAVQDAIAAFLPTLLYWNLQIPKRQKIALGAVFASGYLVCIVCIARVFAIYTIFNNELYDSSWTTWPALLLAVLEIQLGAIVASAPALKVFAKHYFSGASAWGSASARFTYGSGRATDGSVRQGEFRKQSDMAKSASTMERGRGGAEEDDEEGDVALLELRKTETRIVGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNX0</accession>
    <name>M2SNX0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="1">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FDC1</name>
        <name evidence="5" type="ORF">COCSADRAFT_160246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="1"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD63995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699913.1">
        <property type="nucleotide sequence ID" value="XM_007701723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNX0"/>
    <dbReference type="STRING" id="665912.M2SNX0"/>
    <dbReference type="GeneID" id="19132024"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_160246"/>
    <dbReference type="eggNOG" id="ENOG502QR5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_0_0_1"/>
    <dbReference type="OMA" id="TWCALQV"/>
    <dbReference type="OrthoDB" id="4878259at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="2">
        <location>
            <begin position="125"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="4">
        <location>
            <begin position="333"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="175"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD63995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="505" mass="55786" checksum="BF7B40FE44067D70" modified="2013-05-01" version="1">MSSALPASESPSAPHDFRAFLDVLRADNDLVEINTEVDPHLEVGATARRVSETNGKAPLFNNVKGARNGLWRIFSNAAGLRKNENERFGRVARNLGLPKDATWKQICDRSQEGKNKAPIPPNVVPTGPCQQNQILGDAIDLEALPVPFLHQHDGGKFLQTYGVHMLQTPDGSWTNWSIFRAQVYDKRHLVALINPGQHNHMVMEKWKKLGKDVPWALAFGVPPAATMAAACPLPEGVSEAEYVGAMLGRPLDLVKCQTNDLLVPANSEIVLEGTLSTTKMGDEGPFGDYLAHQFDDERRPGSLLKVDRITYRDDAILPVSVPGRIVDESHTTASLASAEMVTLCQSHGLPIIDAYCPLETMGTWCALQVSLPQLALLHTDAASFSQQIGNLVFSSKASMLINRVFLIGDDIDVYNFKDIIWALSTRARPGLDDFPFEDVRGLPIMPYMSHGRGDRKRGGKMVTNCLLPAEYEGRRNWIPVDFESSYPEVVKEKVREIWETTAIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNY3</accession>
    <name>M2SNY3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_199446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699922.1">
        <property type="nucleotide sequence ID" value="XM_007701732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNY3"/>
    <dbReference type="GeneID" id="19134099"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_199446"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="OMA" id="DEIMLHT"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD64005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="568" mass="63554" checksum="186522F042F8AA07" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQX3</accession>
    <name>M2SQX3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_115584</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699285.1">
        <property type="nucleotide sequence ID" value="XM_007701095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQX3"/>
    <dbReference type="MEROPS" id="M28.001"/>
    <dbReference type="GeneID" id="19130290"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_115584"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_0_1_1"/>
    <dbReference type="OMA" id="PNYEYEV"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000093">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="AMINOPEPTIDASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140215" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="149"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="260"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD64685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="508" mass="55142" checksum="DFC32308AB61EDE2" modified="2013-05-01" version="1">MVFLSGFALCAAVTSATALQIPLLSSSNQALLGHPQETKPLVNSTELQELISGDRLMTRAKKLYEIAKLGEAEYNHPTRVIGSAGHLGTLSYIYETLLELGDYYTISNQSFPAVSGNVFESRLVIGDGVPKSAAPMGLTPATRDKEPVHGDIILVNNQGCEASDFPDSVAGNIAFIQRGVCPFGTKSEHAGRKGAVAAVVYNYEKDPVSGTLGTPSPNHIATFGLSGEEAEPVLKKLKQGKHVDGIAYIDAEVNEIQTVNIVAQTTEGDSDNCVMLGAHSDSVTEGPGINDDGSGTISLLEVASQLTKFNVSNCVRFAWWAGEEEGLLGSDYYVASLSDQENQKIRLFMDYDMMASPNFAYQIYNATNAVNPRGSEELRDLYIRWYEDQGLNYTFIPFDGRSDYDGFIRNGIPGGGIATGAEGIKTKEEVGMFGGKAGDWYDPCYHQLCDDVGNVNITAWVINTKLIAHSVATYAQSFKDFPKRELEVAAKSTVYRDNVKYHGDHMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRE0</accession>
    <name>M2SRE0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_89052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699407.1">
        <property type="nucleotide sequence ID" value="XM_007701217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRE0"/>
    <dbReference type="STRING" id="665912.M2SRE0"/>
    <dbReference type="GeneID" id="19141276"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89052"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD64855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="671" mass="72900" checksum="3B70B62E00C5E288" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRE1</accession>
    <name>M2SRE1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_40815"/>
    <dbReference type="HOGENOM" id="CLU_2497739_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
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        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="86" mass="9557" checksum="90A82E7A3D822909" modified="2013-05-01" version="1">MPWHRSAILAYAHHGTAATLETLRAQLTSSPHAMAPETSIHSVTTRGRHMHTTPRSTSALTWVPNPLCPCTRQPTVRITLEQTQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRR7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_30547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRR7"/>
    <dbReference type="GeneID" id="19136262"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_30547"/>
    <dbReference type="HOGENOM" id="CLU_1547271_0_0_1"/>
    <dbReference type="OMA" id="FATCNVV"/>
    <dbReference type="OrthoDB" id="3692124at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="176" mass="19406" checksum="E469169CA12BB4E7" modified="2013-05-01" version="1">MSEWNVETSSLRPSGWEGNTFATCNVVTLDTKTEKDVTVEGRSSGANSNEAIDVISRLNAPNTWLSAISLKGCRDARFGKFQLQSFQCYSCCTHKLRINEVRKTTQSLSILDYSVIGPGFELAMTWDTSQSRLENLHMQDGVLRERTSVPLFDASGGISMCIANSASTPNSAKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SS19</accession>
    <name>M2SS19_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_100700</name>
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    <organism evidence="7 8">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704616.1">
        <property type="nucleotide sequence ID" value="XM_007706426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SS19"/>
    <dbReference type="STRING" id="665912.M2SS19"/>
    <dbReference type="GeneID" id="19129715"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_100700"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OMA" id="FMTPGDI"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD59587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="439" mass="48671" checksum="D267B90F849669D2" modified="2013-05-01" version="1">MQAEKAVGHGDNATTTQDVTNPGNNEAWSDNSEKMKALAWFGKNDVRMIETPKPKVIEPRDVIVKVTGSTVCGSDLHLLHGSVVEMQKGDILGHEFCGVVDECGSEVTKFKKGQRVVASFQIACGDCYYCKQKLSSQCEKTNSNTIENTMYGGRTAGMFGYSHFTGGFAGGQAEYTRVPYGDVNLLPLPDDVPDEQGLFLSDVLCTSWHAVVDTGVKKGDVVAIWGAGPIGQMAADFSLLNGASRVIMIDSNWRLDFIKNKYPHIDTLDFSTLPKGESVTSKLKEMCNNRGPDVSIECAAGEYAKGWAHYFEMMLGLETDTSEIVNEMISSTRNMGRCGITGVYVGYTNHFNIGSLMERGIRLIGNGQAPVHMYWESLLQMIQEKRIDPSKMVTHRVRLEDLDKVYYKFEKKEDGMQKVFVETKWSFPAAKCSPELTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2ST24</accession>
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    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ND90Pr / ATCC 201652</strain>
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</entry>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
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                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
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            <end position="65"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705436.1"/>
    </dbReference>
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    <dbReference type="STRING" id="665912.M2SUQ6"/>
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    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
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    <dbReference type="OrthoDB" id="191315at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHDPS"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD60522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="310" mass="33069" checksum="F0BE2C7966E54F0C" modified="2013-05-01" version="1" fragment="single">MASNGNGTNGHTKQRTPLRPGIYSPTMTFFNPETEELDIPVIKKHAVRLAEAGLVGLVTMGSNGEAVHLSRAEKTAVTRATREALDEAGYQDVPVIVGASEHGIQLTIELCKEAEAAGGEYALILPPSYYRYAIDEDAIYEYFTKVADGSPIPIMLYNYPGAVAGIDMDSDLLIKLAKHPNIVGTKFTCGNTGKLTRVALATNACTAKSNSGGYMAFGGMADFTAQTAASGGSGIIAGGANVVPKTCVKVWNLWAEGKYDEAFELQKVLSKGDWVLTKSAIPGTKSAIQSYYGYGGYPRKPLKRLSQEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SVR7</accession>
    <name>M2SVR7_COCSN</name>
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        <recommendedName>
            <fullName evidence="8">Ferric reductase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_169346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697906.1">
        <property type="nucleotide sequence ID" value="XM_007699716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVR7"/>
    <dbReference type="GeneID" id="19132625"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_169346"/>
    <dbReference type="HOGENOM" id="CLU_1199707_0_0_1"/>
    <dbReference type="OMA" id="LQRHPFM"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding 8" evidence="4">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="5">
        <location>
            <begin position="71"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD66405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26289" checksum="6743BC01067CEA37" modified="2013-05-01" version="1">MRRPGFFSILQRHPFMVADSESDDHDFQLRIQPRAGFTSRLLTQTLYRTRELSAFIEGPYGQGFDLRDFGTVVLFASGIGIVGHLAYVQKLIRDHQQSKTKTRDILLIWHVDDKYQLDLVWEVMNIILRKDDLPSTATHKDTGITSRSGKKDRYLGGSTTGENPGIIDVYIYGDYEIFNEAGNAVSYRRTGSRIAEVKGKPDVRQIINDVLETRNGRLVICGKNFHSLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SW03</accession>
    <name>M2SW03_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_240076</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703488.1">
        <property type="nucleotide sequence ID" value="XM_007705298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SW03"/>
    <dbReference type="STRING" id="665912.M2SW03"/>
    <dbReference type="GeneID" id="19134980"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_240076"/>
    <dbReference type="eggNOG" id="ENOG502QQV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058877_0_0_1"/>
    <dbReference type="OMA" id="HFRYMNG"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="184"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="406" mass="46230" checksum="30FFE7617760A78F" modified="2013-05-01" version="1">MASLKRSPPFRAEHVGSLLRPQELVQKRYDVASGKAQPDELVPLEDKSVAEVVKFQQDCGLKVVSSGEYTRHMFWGTFFETLHGMKELQLGVLKGYNKDMFRAYAPDVKSFMEAKEVPNHVTVCVDKIRHPGKSSNQREVDLMKSLLPESEWKNIKITLISPSWYHFRYMNGSAYPKEVYANDEEYFDDVAKAYQEELKILHSQGIRNIQIDDPNLAYFCSDDMLAGWKADKTNSKTADEMFDSYVKFYNKCFERPADMHLGIHLCRGNYVGSRHFSEGAYDLIAKKLFQDLDVDTYYLEYDTPRAGGFEPLEHLPKGKNVVLGVITSKFPKLEDKDEMIARVNQAADWIAKGTGQSREDALKQCCVSPQCGFASHAEGNALGYEDMRKKLQLVRSIADAVWPGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWH4</accession>
    <name>M2SWH4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_29445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703039.1">
        <property type="nucleotide sequence ID" value="XM_007704849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWH4"/>
    <dbReference type="STRING" id="665912.M2SWH4"/>
    <dbReference type="GeneID" id="19136048"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_29445"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_4_1_1"/>
    <dbReference type="OMA" id="STYMVGE"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF100">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025426" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD61182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="642" mass="68847" checksum="C45685E7AC5A7E09" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWI3</accession>
    <name>M2SWI3_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_240189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703499.1">
        <property type="nucleotide sequence ID" value="XM_007705309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWI3"/>
    <dbReference type="GeneID" id="19134981"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_240189"/>
    <dbReference type="HOGENOM" id="CLU_1204589_0_0_1"/>
    <dbReference type="OMA" id="HRTWDES"/>
    <dbReference type="OrthoDB" id="3684807at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="210" mass="22903" checksum="3A49387AE3D17B4A" modified="2013-05-01" version="1">MARRHSKKKPRNPPVRTESSGSEIPVSPQRVDARTIHQRSRGASEHIYGQSSYAGSCAEPGLPACTNLDQGFSEERTLRQLGFAGGNTAQTNPSMHRTWDESGVGLWWYACGSYTSPGGIALPSTSGERETWQNCAYQGSFLHGDVAAAQRNAEGMVFRTSSCGSVAKRGEGGPLWDVNAYFAYFAPLGTRHMQVVGKEEKREGKKRMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWL8</accession>
    <name>M2SWL8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="12">PAGM</shortName>
            <ecNumber evidence="4 12">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 12">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_39906</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 12"/>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703136.1">
        <property type="nucleotide sequence ID" value="XM_007704946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWL8"/>
    <dbReference type="STRING" id="665912.M2SWL8"/>
    <dbReference type="GeneID" id="19139596"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39906"/>
    <dbReference type="eggNOG" id="KOG2537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022890_1_0_1"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000038">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="95"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="19">
        <location>
            <begin position="183"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="18">
        <location>
            <begin position="303"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="16">
        <location>
            <begin position="459"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="15">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="378"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="503"/>
            <end position="507"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD61232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="540" mass="58776" checksum="5A95CAC8506B7E87" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX13</accession>
    <name>M2SX13_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_303170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698231.1">
        <property type="nucleotide sequence ID" value="XM_007700041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX13"/>
    <dbReference type="GeneID" id="19136221"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_303170"/>
    <dbReference type="HOGENOM" id="CLU_2637909_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026222" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="77" mass="8296" checksum="582B7BD30972BA38" modified="2013-05-01" version="1">MAPTFWYLVLLAPLLGAVQAQCTTPKSRTCNSARTWIIECDAGLHGTLWANCNGANCRTCSTRGGIVYPSCSPCTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX65</accession>
    <name>M2SX65_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_68309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696695.1">
        <property type="nucleotide sequence ID" value="XM_007698505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX65"/>
    <dbReference type="STRING" id="665912.M2SX65"/>
    <dbReference type="GeneID" id="19140449"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_68309"/>
    <dbReference type="eggNOG" id="ENOG502SJ8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004804_0_1_1"/>
    <dbReference type="OMA" id="PNIHHEL"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD66895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="584" mass="65153" checksum="C4232ECA89FC1100" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX84</accession>
    <name>M2SX84_COCSN</name>
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        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_123357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702870.1">
        <property type="nucleotide sequence ID" value="XM_007704680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX84"/>
    <dbReference type="STRING" id="665912.M2SX84"/>
    <dbReference type="GeneID" id="19130554"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_123357"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_1_1"/>
    <dbReference type="OMA" id="NYLANYH"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD61556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44827" checksum="FE0860AB6133E572" modified="2013-05-01" version="1">MPVNIIAQAFAEGIDSIPYGWTIIKAAVVFAAIYALKWFFNGANNGSERNMHSKVVMVTGGTTGIGAEVVRGLASRGAQIVLLVRQPLVDPFLVDYIEDLRTQTGNELITAEHVDLESLHSIRQFATKWVDNAPPRRLDMIVLCANTMTPPGKKATQTEDGLESTWGLNYIANFHLLSILSPALRAQPPDRDVRIIFGTCSSYMGGKLPGLEDKSKKNAKSEPGQLDFTPSTVYATSKLALMTFAVAFQKHLSKYDRPDKKPMNARVIIVDPGWTRTPGMRRYLTFGTLWGLALYTITWPFWWMVLKSADQGAQTFLYAAMEAQWGRGEGAYFLKECRRSIWTRKDIDDELLQKKLWESSEKTIEILEKESAKRRAAEKKQKEKAEGKSAAKSANGRTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>M2SZ19_COCSN</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_173426</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZ19"/>
    <dbReference type="GeneID" id="19132853"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_173426"/>
    <dbReference type="eggNOG" id="ENOG502T5F6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607117_0_0_1"/>
    <dbReference type="OMA" id="GRHQRYN"/>
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    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
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    </feature>
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            <end position="417"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="532" mass="58447" checksum="C7537EEFF761D1E1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0F4</accession>
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        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_32999</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="protein sequence ID" value="EMD68035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697241.1"/>
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    <dbReference type="AlphaFoldDB" id="M2T0F4"/>
    <dbReference type="GeneID" id="19136996"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32999"/>
    <dbReference type="eggNOG" id="KOG0255">
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    <dbReference type="OMA" id="HERGKWI"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="492"/>
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    </feature>
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        <location>
            <begin position="504"/>
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        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD68035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="546" mass="59753" checksum="E0EDD30529E2EC2C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1E1</accession>
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        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_182313</name>
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    <organism evidence="12 13">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="207"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="968"/>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701515.1">
        <property type="nucleotide sequence ID" value="XM_007703325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T2R7"/>
    <dbReference type="STRING" id="665912.M2T2R7"/>
    <dbReference type="GeneID" id="19133364"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_182571"/>
    <dbReference type="eggNOG" id="ENOG502S5MV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031138_1_0_1"/>
    <dbReference type="OMA" id="PTEYSKD"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="423" mass="46834" checksum="B0A030030BB9029C" modified="2013-05-01" version="1">MKRSSSTRVARKIGSYDDDESADSTNSSQSEVQKPIVVKRPALGKAKKRSSLRMSFGAGDEANNGEESSDSAVVTPKKANLSRIALEKSAQLRARSPLVSESAKSTEYSKDYIAELRNSTPSTPRDLKISAEEEEEIHGLDIAAKFGPIASLETMSSAIPTEAEIREKKARRRRLAHEENAYDDEDAAWASDDQGEDEFRQHRDKISLRPKDKWGETRLVHDDEDIAEGFDDYVEDGKIALGRKSEKEAQRRRRAEMAELINDAEGSSGDDGSDDSDEDRNVAFAAAQARAGRYGQKVDEDDDGTRTPPRITSLPDLDDILQGLTIDIEARKHRKALLLQKMQDLKDDKVRIEERKKYLQEQLQKTGEEYEKLRQESGLPALPASTMEGGGPGRLITERGLDSLGTTPLGGTPLANRSSEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2T346</accession>
    <name>M2T346_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_92111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700576.1">
        <property type="nucleotide sequence ID" value="XM_007702386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T346"/>
    <dbReference type="STRING" id="665912.M2T346"/>
    <dbReference type="GeneID" id="19141432"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_92111"/>
    <dbReference type="eggNOG" id="ENOG502S8AN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086431_0_0_1"/>
    <dbReference type="OMA" id="TCRNSAE"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="236" mass="27150" checksum="DFF1807C4D906691" modified="2013-05-01" version="1" fragment="single">LTCSKRQLTSADYLWRSLVGDTIPVDGDVLQDFGFNNYFPWWLKNLHRLQGPTTKEEVEGSLAQTFFDKAKLYLDPRDRNMHPSELKPEAKRDSFLLLSHILYRFTPNPSAMLYHTFAFVTCRNSAEESQLVDKYLLLLVPSDGSFFYTFHNERRSLTHTASFAAFWKVYEAGTLLLLIDSHDLQNLRTRLPHLESFLSVPPSGPHPSVWALKTIPREHGSNNASAYPGNHLRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3Q4</accession>
    <name>M2T3Q4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_37391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700410.1">
        <property type="nucleotide sequence ID" value="XM_007702220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3Q4"/>
    <dbReference type="STRING" id="665912.M2T3Q4"/>
    <dbReference type="GeneID" id="19138970"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37391"/>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD63617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="134" mass="15367" checksum="0EA4E43003C94749" modified="2013-05-01" version="1">MADSQVTLRTRKFIRNPLLGRRQMVVDVLHPNRANVSKDELRGKLGELYKAKKEDVSVFGFKTHFGGGKSTGFALIYDSAEAMKKFEPRYRLVRYGMATKVEKASRQQRKQRKNRMKTFRGTAKAKGGAKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3X0</accession>
    <name>M2T3X0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_31873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="19136561"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31873"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="OMA" id="FWGWSFY"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="466"/>
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    </feature>
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            <begin position="35"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="490" mass="53814" checksum="E9D1D689E6FF505C" modified="2013-05-01" version="1">MSSSQAEREPLLSQVPAKVITFEPNDPEDPRNWPTARKWLMVAAIIPIDLSVSWGASGFSPVAGDFAKDMGVSPSVALLGLSMYVLGLAFGPMTLAPLSEYYGRRPVYIVSYGIFLLMLLGTTYVETLGPFLVLRYFSGYFSSTTISNFGGTIADLFHHNDTGPAMSWFLWAATGGSPTGFVLFSFIAQGRPWHDVFRIMLAICFAFWIILVVTLNFLGETRHSVILLRRARALRKVTGDDSLEVPDALKQRGPKQLFGTALARPFRFLGTEAIVQFGALYNGFLYGLSFLFNGAFHMIFGPSGYGFDTIGVGICFLGIVVGITVGLMTNVFQERYYQWRVAQADGHDVPEARVRYAKLAAIVLPISLLAFAFTATPHIHPLFAVFASAFWGWSFYTLILMTLTYTEDAYKTYSASALAGIGLIRNLAGAGFPLVGRHLFLNIGTRNATLVLTVIAICLAPIPFVLEVRGASLRKRSPWAAAHEDENEDD</sequence>
</entry>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_31893"/>
    <dbReference type="HOGENOM" id="CLU_1250565_0_0_1"/>
    <dbReference type="OMA" id="LELPWAI"/>
    <dbReference type="OrthoDB" id="3693998at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD69130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="221" mass="24998" checksum="55A8D1475A31D868" modified="2013-05-01" version="1">MYKESAFTIGFSRPESTQLFLFVLSELLELPWAIPIVVRTVVTNVSLLASQSYATISSTKPSFDTSKPPLRLLIQTLSNLYTKDKFADDDVESLNSSQDIQNSIPSNIAQSLSPEIPSYEYSPEEWSEEREVVEDTCDDELWKGGSLDDEERRTQALFDELNHLIDECDGLNSAQWNEVIELLNGNEGFDGDRGECMVSAHFEDWAQRDAEIELSVLYPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4M6</accession>
    <name>M2T4M6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_36773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699789.1">
        <property type="nucleotide sequence ID" value="XM_007701599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4M6"/>
    <dbReference type="GeneID" id="19138817"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36773"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_2_1_1"/>
    <dbReference type="OMA" id="IKTRICM"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="330" mass="36661" checksum="F34F9D5373477640" modified="2013-05-01" version="1">MSTTLTSLAPAHIKTRFLIISDTHSATPSQNTTNNGTAFRPPLPKADVLLHCGDLTMVGHLTEYEKTLDMLEGIDAGLKLVIAGNHDITLDADYYGKKGRFMHGRQYDQEISAKAKELWTGERAKQAGVTYLDEGVHIFQLENGANLRVYASPYQPEFCGWAFPYNRDEDRYNPSHQCTPNTKPIADNPIPGFPNIDVMMTHGPPFGVLDVTRTGELVGCQHLLRAARRCRPRLHCFGHIHEGWGAQKVLWNNGELDVKPEQCIQRADTIHVDSGKTANERAATVDISQGSSTAVEFGKETLMVNASIMNVRNDPWNGPWLVDLDLERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2T712</accession>
    <name>M2T712_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_36381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699156.1">
        <property type="nucleotide sequence ID" value="XM_007700966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T712"/>
    <dbReference type="GeneID" id="19138719"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36381"/>
    <dbReference type="eggNOG" id="ENOG502SA4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111658_1_0_1"/>
    <dbReference type="OMA" id="YEFPLRT"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026293" description="ribonuclease T1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD65031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="142" mass="15135" checksum="AA27CFF593AB4E71" modified="2013-05-01" version="1">MQLSTLLLSLLPALTLALPTTDSVESSDVLAAVESRQSCYVKCGSTCYTSAQVTTARNAGYNYYQNNDQAGSSNYPHTYNNYEGFSFLVSGPYQEFPLRTSGAYTGGSPGADRVIFNTRGQRAGEITHTGASGNAFVACSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2T7D9</accession>
    <name>M2T7D9_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_356468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699617.1">
        <property type="nucleotide sequence ID" value="XM_007701427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T7D9"/>
    <dbReference type="GeneID" id="19138433"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_356468"/>
    <dbReference type="eggNOG" id="ENOG502SIWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729597_0_0_1"/>
    <dbReference type="OMA" id="TAIGHIE"/>
    <dbReference type="OrthoDB" id="3782562at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="379" mass="42384" checksum="128434BF554CE2B6" modified="2013-05-01" version="1">MLPVPWKQETNFASALLLHSYITVFLKEISNSTAVLYYIFILAKDKTTIDTSDMLDGYTSVFSRDQDSELAKLYFTNTGFVLLITSLASAIVMNLALPTGVLNALIAATFGLTFLTSAVVTCKKKSFAMPVMALRRTGRFIWSDTPFVNFFSLIYIAIVLKESSKLALRDYVIFRSISILELVFIKARLAAADAETQQVMLKRLVDSKYAVISSKCLPAARSPPKPLEHACIVPSMSSQCLFVVLYKTAIGHIEGSVCGASGPTTMTIPKNPGFFKDEAAQYGWRVYHVLPTYVFIEDCGMAARYTKFISWSHGVLLRRLGRRRVVWLMHTGQDERGAGSWKGNINLVTELKETWFNDRGRFRPMTGDDDGDARVNVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2TB46</accession>
    <name>M2TB46_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_24548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697445.1">
        <property type="nucleotide sequence ID" value="XM_007699255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TB46"/>
    <dbReference type="GeneID" id="19135108"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_24548"/>
    <dbReference type="HOGENOM" id="CLU_885681_0_0_1"/>
    <dbReference type="OMA" id="SRASACH"/>
    <dbReference type="OrthoDB" id="10556959at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD66441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="314" mass="34405" checksum="A4B8AF013487D00F" modified="2013-05-01" version="1">MYKLGQSYSETWMYLQRRVQCSAVQCGAARRQSGLDRTRRMLRLSQRPPGRSSALFTWAHEPLQPENPDQDCHGSPNISLDLDPVRPSFCLSVCLPACLPACLPACPSVRPPIHPIHLLTLTHPSISPCLHPSASLLVLVLPLSLSLSLSLSLLVLPPLLLLLLLPPPSCRPRLAAPRRASLHLTSPLLTFACPSCLRPITSLPARFCRRRFRIHPAAHATLPPRHLPVQPLSSPLPLRSSTASRSPSTRAPVLLCECRPPSDTTTTPDDAHPTCAAPLVSRARLDSRFFPLSPFLSLSLPPSSPPSPWHRNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2TB68</accession>
    <name>M2TB68_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bet v1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_34685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697473.1">
        <property type="nucleotide sequence ID" value="XM_007699283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TB68"/>
    <dbReference type="GeneID" id="19137803"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34685"/>
    <dbReference type="eggNOG" id="ENOG502RXX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124166_1_0_1"/>
    <dbReference type="OMA" id="VWHHIKL"/>
    <dbReference type="OrthoDB" id="10255646at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332">
        <property type="entry name" value="BLL4707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332:SF7">
        <property type="entry name" value="SRPBCC FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD66097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16955" checksum="8772D6956F47F998" modified="2013-05-01" version="1">MSSTIPTSTSVHESAVIEAPFSDVWHLIKLQDFSKFWTKLEKSEFVKGTSDETDIVKWTFKDGAELEVKQEEHSSIDHFITYSVITSKPELSYSSVVSTIRAYPVTSGKHQGQTFVTWSGNFSSDADASVIQDAKFKRREALADLAQAASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TBJ2</accession>
    <name>M2TBJ2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_296249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697777.1">
        <property type="nucleotide sequence ID" value="XM_007699587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TBJ2"/>
    <dbReference type="STRING" id="665912.M2TBJ2"/>
    <dbReference type="GeneID" id="19136081"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_296249"/>
    <dbReference type="eggNOG" id="KOG2309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="OMA" id="HPYKFKM"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD66237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="254" mass="27521" checksum="D8E4EFA524D32F5B" modified="2013-05-01" version="1">MGRVIRNQRKGRGSIFTANTRLNKNPAQFRTLDYAERNGYIRGVVKEIVHDSGRGAPLARVSFRNPYKFKHDTETFIANEGMYTGQFIYAGKNAALTIGNVLPLHSVPEGTVLTNVEDKNGDRGALGRTSGNYVTVIGHNPDEGKTRVKLPSGAKKVLPSSCRGMVGIVAGGGRTDKPLMKASRAKHKFAAKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYATQGQKAGLIAARRTGLLRGTQKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDD4</accession>
    <name>M2TDD4_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_136041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696955.1">
        <property type="nucleotide sequence ID" value="XM_007698765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDD4"/>
    <dbReference type="GeneID" id="19130996"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_136041"/>
    <dbReference type="eggNOG" id="ENOG502QR5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="OMA" id="QFHYSGR"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF42">
        <property type="entry name" value="PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025839" evidence="1">
        <location>
            <begin position="25"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="298"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD67251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="819" mass="90366" checksum="01FE171D2C6A0E6C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDZ6</accession>
    <name>M2TDZ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cellular morphogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_283421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696742.1">
        <property type="nucleotide sequence ID" value="XM_007698552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDZ6"/>
    <dbReference type="STRING" id="665912.M2TDZ6"/>
    <dbReference type="GeneID" id="19135844"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_283421"/>
    <dbReference type="eggNOG" id="ENOG502QQZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005863_0_0_1"/>
    <dbReference type="OMA" id="NMYTPGC"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025893" description="Cellular morphogenesis protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="4">
        <location>
            <begin position="222"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="5">
        <location>
            <begin position="382"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="901"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD66967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1230" mass="130499" checksum="825DE8E943771323" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEF7</accession>
    <name>M2TEF7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_82094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697217.1">
        <property type="nucleotide sequence ID" value="XM_007699027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEF7"/>
    <dbReference type="GeneID" id="19140871"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82094"/>
    <dbReference type="HOGENOM" id="CLU_2855801_0_0_1"/>
    <dbReference type="OrthoDB" id="10377003at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="65" mass="7907" checksum="9EA71937260FBEF6" modified="2013-05-01" version="1" fragment="single">RIPKEFITNRNKLFTSKYWSIFLVNIQIYSIFYKKLLELAPLDTKLVINIELKDDEYKIKEIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEP1</accession>
    <name>M2TEP1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_82367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697289.1">
        <property type="nucleotide sequence ID" value="XM_007699099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEP1"/>
    <dbReference type="STRING" id="665912.M2TEP1"/>
    <dbReference type="GeneID" id="19140888"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82367"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_1"/>
    <dbReference type="OMA" id="KHKIGLM"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="42"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD67696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="245" mass="27153" checksum="2E505A18D34296FA" modified="2013-05-01" version="1">MAPETQSSAPSQCVGPEYRPSALKPTATVSTPIKQSNVHILPQSPQLIALLTMIRDRNTGRADFIFYSNRIIRLLVEEGLNHLPVESQEITTPVGRTYSGVKFQGKICGVSIMRAGESMEQGLRDCCRSVRIGKILIQRDEETSKPKLYYDKLPEDISDRWVLLLDPMLATGGSALMAIDVLKSRGVPEDHILFLNLIASPEGAQSLAEKFPKVRVVTAFVDEGLDEKNYIIPGLGDFGDRFYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2TF76</accession>
    <name>M2TF76_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_22397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="665912.M2TF76"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_22397"/>
    <dbReference type="HOGENOM" id="CLU_1304755_0_0_1"/>
    <dbReference type="OMA" id="HMLLGYV"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23291" checksum="A79269AD5B14C6D8" modified="2013-05-01" version="1">MAKDLVLITGAASHVGFATLQKHLEDVEFVLISDLQEPSGLKEAIKGVSGVIHVATPIPLKLDRDAMAYYAALKFIETKKPYFDVIHMLLGYVQGANELYSSAEEMVDTDRCGSNNGVILTAAYVLFLEPENAKGCDNFILAGHSGQNVPWKEFVPIIRERFPDARNDDILISFDVNNSEAAFGKFLGSEEMIQNVVSQYVDLLESQDSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2THB6</accession>
    <name>M2THB6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">COCSADRAFT_33503</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695561.1">
        <property type="nucleotide sequence ID" value="XM_007697371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2THB6"/>
    <dbReference type="STRING" id="665912.M2THB6"/>
    <dbReference type="GeneID" id="19137197"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33503"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075666_1_3_1"/>
    <dbReference type="OMA" id="FCPFAIR"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMD68621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="138" mass="14898" checksum="E7509626966DCF0A" modified="2013-05-01" version="1">MPPKAQKTPTTGGKAPAGKAPAEKKEAGKKTAAPSGDKKKRTKTRKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIQ9</accession>
    <name>M2TIQ9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_130438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694521.1">
        <property type="nucleotide sequence ID" value="XM_007696331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIQ9"/>
    <dbReference type="STRING" id="665912.M2TIQ9"/>
    <dbReference type="GeneID" id="19130788"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_130438"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_1_1"/>
    <dbReference type="OMA" id="CILQPRT"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="75"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD69086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="519" mass="56202" checksum="79E9D223154E9360" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2TIY1</accession>
    <name>M2TIY1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_157073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696203.1">
        <property type="nucleotide sequence ID" value="XM_007698013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TIY1"/>
    <dbReference type="STRING" id="665912.M2TIY1"/>
    <dbReference type="GeneID" id="19131804"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157073"/>
    <dbReference type="eggNOG" id="KOG2206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010129_0_1_1"/>
    <dbReference type="OMA" id="TMDIIWL"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="440"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="654"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="791" mass="88354" checksum="BF6FADB8570532DA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJ64</accession>
    <name>M2TJ64_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_80091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696269.1">
        <property type="nucleotide sequence ID" value="XM_007698079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJ64"/>
    <dbReference type="GeneID" id="19140767"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_80091"/>
    <dbReference type="eggNOG" id="ENOG502SJ54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007901_1_0_1"/>
    <dbReference type="OMA" id="PHAVRIY"/>
    <dbReference type="OrthoDB" id="5323870at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="71113" checksum="4D89C9ACC83E6F07" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJT9</accession>
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        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_185997</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694437.1">
        <property type="nucleotide sequence ID" value="XM_007696247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJT9"/>
    <dbReference type="STRING" id="665912.M2TJT9"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_185997"/>
    <dbReference type="eggNOG" id="KOG0805">
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    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="OMA" id="WYPYFSF"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD68967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="325" mass="35684" checksum="BDD15B351B850E01" modified="2013-05-01" version="1">MGDRVHPTVRVAITQHEPMWLDLEATVQKTITIIKEAAEAEAKLVAFPECWIPGYPAWIWSRPVDFDLGTKYVQNSLKTDSEEMKRICAAAAENKINVSLGFSERDGDSVYIAQALISEYGEIKMTRRKMKPTHMERTIFGDATGGKSCLSKVVDLPGVGRVGGLSCWEHIQPLLKYYTFTQSEQIHVGAWPAVAGFIEGSSGFYSMSIEGCRNISQSYAIESQAFVLHCTTVISEAAIQMMETAGAPIMGHPNQGSSCVIGPDGRILSKIDSPNEKLIIADLDLSLVTKAKTFVDASGHYSRPDLMWLGVDETHKPVVRGVENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2TN04</accession>
    <name>M2TN04_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_216783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TN04"/>
    <dbReference type="GeneID" id="19134507"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_216783"/>
    <dbReference type="eggNOG" id="ENOG502SN38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_6_1_1"/>
    <dbReference type="OMA" id="VWEDEGN"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="60"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD70077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="528" mass="58559" checksum="EEB79784D994EB01" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2TN52</accession>
    <name>M2TN52_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_156234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695244.1">
        <property type="nucleotide sequence ID" value="XM_007697054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TN52"/>
    <dbReference type="GeneID" id="19131744"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_156234"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="MFWANTI"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="508" mass="55721" checksum="D5F52B2199D558AF" modified="2013-05-01" version="1">MAEDKVSVEHKRDEDIAEKISHSSKSGELEAQPTEYDEAEAARVLRKVDVRLVPMLALLYLVAFIDRSNIGNAKIAGMTDDLKMNGQQYNTAVTLFFVPYTLLEVPSNIILKMMRPSYWMAILMGSWGLVMTLMGLTSSYGGLLAGRFFLGVTESGFFPAATFLLTLWYRRFELQRRMAVFYVAASLAGAFSGLLAYGIEKLDGRSGLAGWQWIFLIEGLIPVALALVIWKILPDSPETAKFLTQPERDLLVARLSNDSGSGQGQTTNNDKIGKEQILAGLSDWKIWAATLVFWGNTVGVYGFTATVPSVIKGLGYTSANAQLLTIPIYVFAAILTLIFAWASDLTRKRSPYIIAGYSIAIAGFIAQLAIPKPKYPGITYGFLFPVAGGLYCPFTCLVSWIGNSLAPSSKRAVGMALLISVGNMGGIMGSNIYLAREAPKYRTGFAASLAMCCLAIIMTFVLRWAYSRENAKRDALIAAEGEDAVRARYSPEELLLLGDKSPFYRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2QT12</accession>
    <name>M2QT12_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_104132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445657">
        <property type="protein sequence ID" value="EMD58314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705979.1">
        <property type="nucleotide sequence ID" value="XM_007707789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QT12"/>
    <dbReference type="GeneID" id="19129890"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104132"/>
    <dbReference type="eggNOG" id="ENOG502SPB4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045435_2_1_1"/>
    <dbReference type="OMA" id="WVLDFED"/>
    <dbReference type="OrthoDB" id="5332316at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="425" mass="47968" checksum="9E45B5554D970E12" modified="2013-05-01" version="1">MTSSTDLRVDSENGSREAAKAEEGPEAKQDVSFDDSSKLLPSSLPSEEVSEQSLLEELFPEANSAPPPRPTKKSRDQYPRLELPKSIIRPEPVGGPRRVEKRATEPFQQHREQIAVLQLTNCSTGLTEADFRRIIPKGKHLEGWRQDSDFYKVIPGRDPVSLERLPFYYLLFKNTEAALAYQKNASRLHKLSARYQPSSILSAIPPPKGFLEDGEDIGAAVASYNLLPKDHAMSLNVLMQPYNPALRLLIERGGYQPIAPGVDEKGNRIWRVLLHIEGYEPSASDIYIAICTDAYKQGSLVPLRNESQSSIHRLRDMINLKMSGKLISSSRPRAYGTFDHSVSPLTNAASSSIMGSAEEDRSAAQMNQEAMNRVYNRWVLDFEDEHSARRWCMRWHRKVFPEPSGGDTSWKDNEEVRMCNAEVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2QW09</accession>
    <name>M2QW09_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_30747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704817.1">
        <property type="nucleotide sequence ID" value="XM_007706627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QW09"/>
    <dbReference type="STRING" id="665912.M2QW09"/>
    <dbReference type="GeneID" id="19136300"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_30747"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_0_1"/>
    <dbReference type="OMA" id="VHANWRY"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD59284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="427" mass="49594" checksum="4160ECDDD4B8FE14" modified="2013-05-01" version="1">MRPFRPLFRVSRALELPHNYTSQRTLRTSQICSRQLHSSQSRRVDLPQSSRPEKPDPLEEWRNPEPSKWPNRIRLLFVPFIGALVYSMWTDDTIKTEAPTIAEKDALLKRENGVSEQSPMRLRMEQFIKQQQKQIVAELEKVDGTKFKIDTWQRPEGGGGITCVLQDGKVFEKGGVNTSVVYGRLPRAAIQKMRVNHKALDPDVDSLAFFAAGLSMVLHPHNPNAPTVHLNYRYFETADDHGNTTAWWYGGGCDLTPSYLYDEDAILFHNTIKNACDKHDKAYYPRFKKWCDEYFNNKHRGETRGVGGIFFDDLDETEKDQEQLFSFVQDCLAAFLPSYIPIINRRKDMPFTPEMKQWQQIRRGRYVEFNLVHDRGTAFGLNTPGSRVESILMSLPLTARWQYMHAPEKGSREERLLEVLRKPKEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZ86</accession>
    <name>M2QZ86_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_40000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703586.1">
        <property type="nucleotide sequence ID" value="XM_007705396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZ86"/>
    <dbReference type="GeneID" id="19139619"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_40000"/>
    <dbReference type="HOGENOM" id="CLU_2704638_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="73" mass="8348" checksum="6C0C91734F6FBE64" modified="2013-05-01" version="1">MYIDTCTCVHSTHHPQPDQFDREANNNTNNTNYDAPWARPRPRPTPSIHPSIRCKVDGPLLQVTDVSRMQSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2QZZ8</accession>
    <name>M2QZZ8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_174912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445650">
        <property type="protein sequence ID" value="EMD60639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703937.1">
        <property type="nucleotide sequence ID" value="XM_007705747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2QZZ8"/>
    <dbReference type="GeneID" id="19132936"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_174912"/>
    <dbReference type="eggNOG" id="ENOG502SWTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159478_0_0_1"/>
    <dbReference type="OMA" id="KSIFGMR"/>
    <dbReference type="OrthoDB" id="6604875at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD60639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="91" mass="9899" checksum="2426C69EDFD39774" modified="2013-05-01" version="1">MSQRDADTPTFQQALKQDRAQFEDCTPCRVVGSATFLGLGAFTYVSGHSQIRANQAAIRASNSIFGVRSRHIAITGTSAVMVGLGIYRWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2R237</accession>
    <name>M2R237_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_201760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702699.1">
        <property type="nucleotide sequence ID" value="XM_007704509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R237"/>
    <dbReference type="STRING" id="665912.M2R237"/>
    <dbReference type="GeneID" id="19134200"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_201760"/>
    <dbReference type="eggNOG" id="KOG2874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="119"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD61319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="344" mass="39792" checksum="DE2C9E12C9E3112E" modified="2013-05-01" version="1">MPSTHNVDKPWDTDDIDKWKIEPFKPEDNKAGAFTDESRFSTLFPKYREQYLKGSWKFITQALQRLGIGCELNLVEGSMTVWTTKKTYDPAAILNARDLIKLLARSVPAPQAIKILEDDVAMDIIKIRNLVGNKERFVKRRQRILGPNGSTLKALELLTECYLLVQGNTVACMGPYKGLKQVRRIIEDTMHNIHPIYAIKELMIKKELAKDPELANESWDRFLPNFKKRSLSKRRIPHKVNDKSKKPYTPFPPPQEKSKVDLQIESGEYFLGKHAKERKVQEEREEKMKDKMDAKRKERMAEYVAPEEDGDKKKKKRKREEGEGKDKKKKKKHSAEGEANGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2R3H5</accession>
    <name>M2R3H5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_39464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702655.1">
        <property type="nucleotide sequence ID" value="XM_007704465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R3H5"/>
    <dbReference type="GeneID" id="19139503"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39464"/>
    <dbReference type="eggNOG" id="ENOG502ST5U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133420_1_0_1"/>
    <dbReference type="OMA" id="CGKQSKD"/>
    <dbReference type="OrthoDB" id="5415072at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
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            <end position="57"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
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    </feature>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD62454.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
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    <dbReference type="OMA" id="CALDIMA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="244" mass="27235" checksum="F7146E8E30623F12" modified="2013-05-01" version="1">MSSTSTHGYGYDFPETPPNPTTGRIAVAPVHHEPPPLATVQQLSRFGPRWNIRDVCQQLAQYTLEMGIVEGTTDEWQRTQDPEADFTFHCALDIMAASLFRAKQLVLRHRRGFSEAESVLIGKEIKNVDWGMTHLLYSFVAIRHLETPTMAWNVGTGIERHFFLFKTFQTALEGKLVGEGKEEADKYFAKTNKYFEEVIILFKGPPGSKRPEEDATLGNFAEINEPLPAGSAAAPPAEPEKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_139708</name>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698689.1">
        <property type="nucleotide sequence ID" value="XM_007700499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RFQ9"/>
    <dbReference type="GeneID" id="19131129"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_139708"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OMA" id="LGMSWSV"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="80"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD65584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="479" mass="52291" checksum="A1ED5DBC350A1AB6" modified="2013-05-01" version="1">MTSHSTIGGKEPIIDDKAVSQDEYSCTSSEQHSEEVVEQHDERDTPRSTSMAPDKEAQLDARSTLTAESGLPPAPDGGLHAWLKVLGGFLIYMNIWGFTLTYGAFQSYYRTSLLSSSSASAISWIGTTQAWLLIVVGVLSGPLFDMGYFRSMLLIGNFLVVFGVMMLSLSTKYWQVFLSQGICMGLGAGLLYIPSLAMVGVWFDKRRNVALGIVMSGIAVGAIIYITMFNNLVHRVSFPWAIRSLGFVALVTALLSIPALLSGSAWLNKPRKRRALFDKSALHDRLFLMFTITSFTSFLGYNVPYFYIPTYAREHLGTDERTALYMLVMAIAGSFFGRLGVGFLAHYMGPILTWALCSTCSGILALSWLSIKDEKSFRAFSILWGFFSAGLVTLPAAAFASITTDMSRLGTRLGMSWSASSVATLIGAPIAGALLTRENGRTNFIGVQLWSGIFLLLATGTLAVLWAMVVSKKKSGWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RGU2</accession>
    <name>M2RGU2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sodium bile acid symporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_35908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698429.1">
        <property type="nucleotide sequence ID" value="XM_007700239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RGU2"/>
    <dbReference type="STRING" id="665912.M2RGU2"/>
    <dbReference type="GeneID" id="19138602"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35908"/>
    <dbReference type="eggNOG" id="KOG4821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039013_3_0_1"/>
    <dbReference type="OMA" id="RYVFKQL"/>
    <dbReference type="OrthoDB" id="188035at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48115" checksum="BB19D1548FA7ACEC" modified="2013-05-01" version="1">MNEIPSQAPAAFLTTDRAGRIDGATTTNTSSSLHTPTIHHPIPDKASPEQHSHKTDESQATKNKLTNAAKTLQVLKWFIKDQWFLLAMGAVVLVSSQVQVPASQQRIKRTVITYLAVSVIFFINGCTLDTRVMLANYMRWKLHIFVQLQCYLVCSAATFAIVSLCATNPHFMDPWLLIGFLFVGSAPTTMSSNVVMTRQAHGNAALTVVQSVIGQFLCPFLTPIILQMYLSTGSWYSKVLQRGSGYADIYQRVFMQLGLSLFLPMLLGQIVQRLFPKTTKKVFFDWKLLKLSSIALLTMVWQTFDQAFSSGAFEAVKPSNIIFIVFITIALYMIWLAICFTAASLWLPKKDVIACCYCCPAKALAMVVPLTSVMYINIDPVNQSKMQIPAIIFQAFQVAIGGIMTIGFRKWIRPEEEREEAEKLVEAGARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2RHI4</accession>
    <name>M2RHI4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_112360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
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    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007699560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RHI4"/>
    <dbReference type="STRING" id="665912.M2RHI4"/>
    <dbReference type="GeneID" id="19130178"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_112360"/>
    <dbReference type="eggNOG" id="KOG2876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022821_0_0_1"/>
    <dbReference type="OMA" id="DMEHEPL"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="715"/>
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        <location>
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            <end position="246"/>
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        <location>
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        <location>
            <begin position="487"/>
            <end position="497"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="551"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
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    <sequence length="730" mass="82181" checksum="B74DBD60F5B6C045" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="TMTIFFN"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHH phosphoesterases"/>
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    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="268"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="427" mass="47289" checksum="617E775E0262DAF9" modified="2013-05-01" version="1">MAVPRNSLRAFLTHARGALRDAIDCSQKITFVIGNESADLDSMSSSILYAYLRSMSPQKKAFSSVYVPITNIPAADIQLRPEYLAVFKHANIESKHLITLDDLPALSDIRSKLAPENTRWILVDHNALQGQLGDIYADRVAGVVDHHDDEGKVPADTGEEGRIIEKSGSCTSLVANYCRPAWDVLSESSMSSGASHGQDDSLSNDAAFVQQWDADIAQLGLASILIDTANLQDASKTTEHDREAVGYLEAKIMLCPRLAASFDRTRFYEEIDAAKKDIGSLQLQDILRKDYKQWDEAQRLGISSVVKCIGFLEKKAGDEGNASPREALLQAIKKFAKDRELGVFCLMTTSTSASGQFERELLLWAFDEAGVSAAKAFAANAREELGLEDWQGYSDLDSGSEWRKVWWQRQVQHSRKRVAPLLREAMT</sequence>
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<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
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                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD67759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="155" mass="17828" checksum="4DCC93BC07BE7DD0" modified="2013-05-01" version="1" fragment="single">KDVRAGQFRIYNPTNDGVLFSRTIQELETGYVSDAIETFNDQWFTFEVETLELINIEFDLKNTVTECVRFVSIYSQEATNRTSEPPTPLIKILETTEQQYTFDSEVGLELGISIKFSSESLSSQRLRWRSVRRSIQTCCGALRTVMLRPGKPLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">COCSADRAFT_273329</name>
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    <organism evidence="3 4">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007697901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RPI0"/>
    <dbReference type="STRING" id="665912.M2RPI0"/>
    <dbReference type="GeneID" id="19135664"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_273329"/>
    <dbReference type="eggNOG" id="KOG3715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030576_0_0_1"/>
    <dbReference type="OMA" id="CDNCAMT"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
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    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Folliculin"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="188"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="325"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
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            <end position="107"/>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD68509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="438" mass="46963" checksum="00A096644E8CA7E2" modified="2013-05-01" version="1">MDFTISLAHFCEVHGPTSIICTQASTSPCGSCNPCVTPPSDEPHLACSYNGLYDQPTSLKLNPRAPQLNSPFDSPPTSPNSPSHNPYFPSCSSSSAGSSFGGRRPSSTLESDSDVCENCQMVVPQKYSDKIPNGAPGSPTKDGRGRNGSPVLRSSQSYPVRRPISRDDVSSTDSSDVSDTEQSASFQSGNSSLYPDSIPASPSLSSRSVHTHTLNYISTSQPQSPSTYSLLRRTCIRTLSTEVLPLSKPSGPIMFGDSVAGYTIAYVFRLQDPRSRGAKRTYALIAMAGRDCRRATKAMVKITEAFEGIANRIISLADRVLERESAASQSIPRPATAVPGSTPPLGTSASSTSSTTSQLLSPQKERTSSTTSAPSFRNITPVSSFLSAKKLDPDGFPRVSRDVMKAKSLIEIVGQENFFVDLHTLFCRLLHSLIKQYG</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445690">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RSD9"/>
    <dbReference type="GeneID" id="19129927"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_104620"/>
    <dbReference type="HOGENOM" id="CLU_3019812_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="56" mass="6472" checksum="EE68ACDCCEC5A3FE" modified="2013-05-01" version="1" fragment="single">ITAFKTKYRLFKYIVMLFRLTNALATVTVRAHGQRGQARVQVLLLQLINRLSLQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2RSU4</accession>
    <name>M2RSU4_COCSN</name>
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        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_41976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445657">
        <property type="protein sequence ID" value="EMD58308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007707765.1"/>
    </dbReference>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Salamov A.A."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
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                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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    </evidence>
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        <source>
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    <sequence length="1850" mass="210607" checksum="17C063F0728BAC11" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
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                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
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                <person name="Ciuffetti L.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
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                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Lindquist E.A."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445653">
        <property type="protein sequence ID" value="EMD59338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705071.1">
        <property type="nucleotide sequence ID" value="XM_007706881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RW95"/>
    <dbReference type="STRING" id="665912.M2RW95"/>
    <dbReference type="GeneID" id="19131607"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_152992"/>
    <dbReference type="eggNOG" id="ENOG502QQSQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031135_1_0_1"/>
    <dbReference type="OMA" id="RDLYWWA"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF1">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD59338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="52100" checksum="033697C069B94734" modified="2013-05-01" version="1">MASSNSNIPTPVPFPQPPGISNQVTSNSVPESSTTNGRDRSSTNASTVSSRLRSATGKLMEANPPPGMWAATGTTAARAPSLSDIRTGSFGSDGWNEHAQRSRAGSRASRRASGSRTSTTVTATSEQPEPSHTATRKSSSNNVLGTQSFPALVEEDTRQVAEHDIQHNAVPDAPSKHSSDTATEYVDGDRPQQPKRTSSGRYTNGYIPPPKLPWKQTLAISLKSFWKWFLTPAGFLITLYCLNIVAWGGMLFLLLCNAAPAMCKPTCDDINSPRRVWMEIDSQILNALFCVTGFGLAPWRFRDLYWWAWWRIGGSKRTETGIRRLAGIHRGWFRLPGSEQLPDDADATCVDPQNPAVPIPVKAIPEPPPTAMRAPPTKSWTMDVVVWFNVWNTLFQICLCFYMWHYDRIQRPSWATGLFVALACGVSGAAGYIMWQEGNKVKKIEGVPMRKDYGPTDAEASLSVPLVRTGVATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXL1</accession>
    <name>M2RXL1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_175637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KB445652">
        <property type="protein sequence ID" value="EMD59798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704767.1">
        <property type="nucleotide sequence ID" value="XM_007706577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXL1"/>
    <dbReference type="GeneID" id="19132980"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_175637"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_2_1_1"/>
    <dbReference type="OMA" id="YNAQALC"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000147">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD59798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="554" mass="61751" checksum="930C0503DF934264" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2RXS0</accession>
    <name>M2RXS0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pectate lyase</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_164043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704169.1">
        <property type="nucleotide sequence ID" value="XM_007705979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXS0"/>
    <dbReference type="STRING" id="665912.M2RXS0"/>
    <dbReference type="GeneID" id="19132287"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_164043"/>
    <dbReference type="eggNOG" id="ENOG502S66G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_1_0_1"/>
    <dbReference type="OMA" id="NYWIDHV"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000036">
        <property type="entry name" value="Pectate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024843" description="pectate lyase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD59863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="318" mass="33674" checksum="FF7104AA0D56953C" modified="2013-05-01" version="1">MKFSVLSLSLMAVSTLAAPSSFVKRQASLEDVAITGFATTNGGTSGGKGGKVVKVATLADLEAAVKGDAAAIVVITGPISGNGDNVHIGSNKSVIGKDPSVVLSDFTLIAKGVKNVIIRNVVVRNVVHGDAIAIQKAQNVWIDHVEVSSDRSHDKDYYDGLIDITHAADFVTVSNSYLHDHWKCSLVGHSDKNAAEDKGHLTVTYNNNYWRNINSRAPSIRFGTGHIYNNYFENVNDGINVRQGAQVLVQNNVWVNPVKALYTIDNGFAVASGNDFGNSSNTAPVGTLTKAPYAVPQLLDAKDVKAAVVGIAGATLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZ65</accession>
    <name>M2RZ65_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_241546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_241546"/>
    <dbReference type="HOGENOM" id="CLU_2440517_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000016934">
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD60328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="78" mass="9090" checksum="B87DDCF31066F1FB" modified="2013-05-01" version="1">MDKSRVPTRKRNGTPRRTLDFSQKRSKIACHPPIFKKTLRFSANYLREFDSRYQKGLPLSACAGICGILYLVRFLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2S0Q6</accession>
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        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_192685</name>
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        <lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMD60833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007705026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S0Q6"/>
    <dbReference type="GeneID" id="19133815"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_192685"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="OMA" id="PGCEVEN"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD60833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35353" checksum="B54E545EF0B3DDA2" modified="2013-05-01" version="1">MNTLVYRADPPLEGCTEVGLPGCEVENTIYGYYPNLGANVFFAAYFGLAFVFQIYFGIRYKTWTYMIALGCGCLAECIGYIGRILLHENPWNDVGFNIQIVLLIFAPAFLAAGIYLTLKHVVIQFGQEWSRLRPSWYTYIFIAADLLSLVLQSAGGALAATAEDGDAILDIGTNIMIAGIIWQVVALALFGLLVLEYSIRTYRRRDRLSPSALALWENRRFKFFCSAVIVAYVTILVRCVYRIPELLGGWGGELMQEEVEFIILEGAMIAITVLAQTVFHPGLCFPPLGNTFGKKKHVDTNTLETGTAMSEQERIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2S2I3</accession>
    <name>M2S2I3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_123017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
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                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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                <person name="Kema G.H.J."/>
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                <person name="Wang R."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    <dbReference type="OrthoDB" id="3943268at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD58045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="53" mass="6073" checksum="F11FC811AB8B4DA6" modified="2013-05-01" version="1">MDGQVVVITRYHKTQSQWDKPKVVARFLPKAVGQLVTAYLLYLRPVRAMLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2S6Q8</accession>
    <name>M2S6Q8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_37728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700971.1">
        <property type="nucleotide sequence ID" value="XM_007702781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S6Q8"/>
    <dbReference type="STRING" id="665912.M2S6Q8"/>
    <dbReference type="GeneID" id="19139065"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37728"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_1"/>
    <dbReference type="OMA" id="DIIMGCV"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF9">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="285"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD62833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="408" mass="43776" checksum="79C8CB33A0EB15A8" modified="2013-05-01" version="1">MASFSRAARNILQKNPNDVVLLSAVRSPINRSFKGGFKDAHPEDILMPVMQAAVQRAGIEKSDVNDVLIGNVLAELGFAKTGRMALNHAGFPNSTTFHTVNRQCSSSLQAITHIAHSIMVGQVDVGLAGGVESMSRNYSSRGIPTDVSPTLLESNVKDARDCLMPMGITSENVAERYGVDRKSQDEYAVRSHGRASRAQKEGRFDWETVPVKVRRIDEASGQPAEFEVTKDDGIRHGLTFEKVSTLKPVFGEKGKSTAGNSSQISDGASSTILARRSWAEARGLQPLGRFVGTQIKGCAPDEMGISPIFAIPALLKWTGIELKDADIIELNEAFASQTIACIRKLGLDEEKVNPNGGAIALGHPTGATGARQTATLFGELRRQDKEIGIVSMCASTGLGVASLFVRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2S7N8</accession>
    <name>M2S7N8_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_63040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD63123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701303.1">
        <property type="nucleotide sequence ID" value="XM_007703113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2S7N8"/>
    <dbReference type="GeneID" id="19140404"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_63040"/>
    <dbReference type="eggNOG" id="ENOG502SUWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128883_0_0_1"/>
    <dbReference type="OMA" id="WGHNYAV"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD63123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="159" mass="17622" checksum="E6B52AF66E85583C" modified="2013-05-01" version="1" fragment="single">QPPPSASQTYKSLHTTSLSFLSAQSFNPSIPTRMDIPLLKSLCTPSFTHTFGHHHAVSIAPPLQGTFSFDAFAAHLGAMVPRMESWDLRVSDVLVDEAQMRGVVRVSYFMRVKGVGEEDVVENDILWILGFEKEGEEVKVCRSVEFVDGVAAGRLRELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2S853</accession>
    <name>M2S853_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_328705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ND90Pr / ATCC 201652</strain>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
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        <source>
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    </evidence>
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</entry>
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        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="118" mass="12598" checksum="2F515AEBD9D3A8F2" modified="2013-05-01" version="1">MTDLLHVLPDFDATPFSHLLPSLDKALITTNDVLTLDAPTIAKRAQVPSGELRKLADAVVAALHRQLGFGPEEPAPTTKHDWACISTLDDELDAALGGGIPRGYLVEVTAAPARRSCF</sequence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    <dbReference type="GeneID" id="19136421"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_313334"/>
    <dbReference type="eggNOG" id="ENOG502REZ6">
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    <dbReference type="HOGENOM" id="CLU_061220_0_0_1"/>
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    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
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    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="31"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33002" checksum="8AF897617DCBDFED" modified="2013-05-01" version="1">MASSAPPSNGSSRSSLNPFAKRDEHSSQAILLYKITTSLSYLLLVITTFYYTFHAPSGHGAHRFWQNNIPTPFAQSSLFTSIYWLILFAVQLVYAYALYMSDTVYVTAAANIGSHFIANNLLLFGFVNLFVRSHFWLAEVLLVINFFNLAFAYFRHSTTPRAIHIGIVSGPLAWNFVALDWCGAIALHTNHEAFRIVCNLFIWGWLAFGLFFLVAYKDYTMGFALSLLAFSTGVGQFLTRPHILQLQWIFAFTIGGLLFVLSLAVGVPGLLGRDPFPRGHVVSEDRERAPLLADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2SBV9</accession>
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        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
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    <gene>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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        <property type="entry name" value="ribofla_fusion"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD59980.1"/>
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    </evidence>
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    </evidence>
    <sequence length="166" mass="19170" checksum="44BBE437DACB9A12" modified="2013-05-01" version="1">MVKDTGTVYFNKNSAEYGFMSNMHIAPFTVEEVEYKSTEHYFQAAKARHFKDLDLLREILDCDDPVKAKSFGRRVHPFDLNEWDELKEVVMKEGNMHKYAKNPTLQEKLLATGDLHLAECNPRDRFWGIGVGKAKAEAAGKYPGKNVMGFILEDIRKHFRDEAKQK</sequence>
</entry>
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    <organism evidence="7 8">
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        <lineage>
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            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SCH2"/>
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    <dbReference type="OrthoDB" id="2243669at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
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        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
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        <location>
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            <end position="54"/>
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        <location>
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            <end position="78"/>
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    </feature>
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            <end position="118"/>
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    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="130" mass="14373" checksum="1A5BC200B735F2B7" modified="2013-05-01" version="1">MSTQPLLQTAPGKRIALPTRVEPKVFFANERTFLSWLNFTVILGGLAIGLLNFGDKIGKISAALFTLVAMMAMIYALFTFHWRARSIRMRGQGGFDDRLGPTILTIALFAAVIVNFVLRLTMGGDENSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SCL9</accession>
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    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="665912.M2SCL9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD65028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28003" checksum="B982BD74A3880175" modified="2013-05-01" version="1">MSNQEINNARFSAEALEWDSNKKHVESTANALEAIKRYVPAFKEGRNKNLDVLEIGCGTGLLSFMLAPHVRSLIGVDTADGMISAFNIKLANLPTEHPNLCSVNHFLTNPDAHELQSAAALLATHRGEEPKPPYEYRFDLVVSHLTLHHIPSMPDILQTMHKCLRHGGVVALTDYEDFGPEAVPFHPVSKRPGVERHGIKKKEIEEMLLGTGFNEVRVEEAFVLRKEVEAEDGKPAREMDFPFLICFGVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SD20</accession>
    <name>M2SD20_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_141822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD65178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699649.1">
        <property type="nucleotide sequence ID" value="XM_007701459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SD20"/>
    <dbReference type="STRING" id="665912.M2SD20"/>
    <dbReference type="GeneID" id="19131217"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_141822"/>
    <dbReference type="eggNOG" id="KOG0280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036100_1_0_1"/>
    <dbReference type="OMA" id="LDMKWLP"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD65178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="379" mass="41617" checksum="CC223BA9EC9C7ECE" modified="2013-05-01" version="1">MSSIRSLTSFKLDLPPSCIEFFPLNPQYAVVGTYNLEKSDEKDAAGSAPHDGKVSAKNQQRNGSLILVKVDGDNVNIIQTLATPSAILDIHFLTHVTSSNFGVATSTGAFAIYELQSWQRNPSISHIKTIQYFPEDVLITAFSWHPESFMVGMTLSNGQVCLGVIDTESEDDSPTKLEVASHDLEAWTLAFLPDGSGLLSGGDDSTLRFAELSDGSGVSVPWMDGKIHGAGVTAILPVHLDTQGLLVITGSYDDHLRLVHVPISGRRQVLAETNLGGGVWRLKLLDRNPKLPENHGVEKWRSEPPPEAILLLVSCMHAGTRIVRLTKSAGEWKIEVLAKFEEHESMNYGSDSQPELNGQGQRTYISTSFYDRLLCLWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2SHI0</accession>
    <name>M2SHI0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_113354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Utilization of purines as secondary nitrogen sources, when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698090.1">
        <property type="nucleotide sequence ID" value="XM_007699900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SHI0"/>
    <dbReference type="STRING" id="665912.M2SHI0"/>
    <dbReference type="GeneID" id="19130220"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_113354"/>
    <dbReference type="eggNOG" id="KOG4145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038797_0_0_1"/>
    <dbReference type="OMA" id="MDDGWET"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="202"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD66663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="343" mass="37915" checksum="BAFD09FAECCA7DCA" modified="2013-05-01" version="1">MARSIPIEEIDSTFKSKYTDLISAPLGSKVLSFSDEYFAAAENLITPTPPIRKPGVFVHTGAWYDGWETRRHNTEPADWVVLRLGTASGKVAGIEIDTAHFNGNHAPEIAVEGTFVSDEKDEEEVKKPSYAGWETILSKQECGPSQRHGWLLPNITEKAYTHVRLLMYPDGGIARFRLYGVAVPVFPQSADAVFELSATVMGGVATSCSDQHFGTKDNLLLPGRGKDMGDGWETKRTRGEHVDWTIIRLGAKGEIDHIVIDTAHFRGNFPQKVQVFAGAFDKDPSHDDARWTEVLAPQKSGPDTEHVYKAELKEVAGKGYTHAKLVIIPDGGVKRFRVFGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2SJG5</accession>
    <name>M2SJG5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_146302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701843.1">
        <property type="nucleotide sequence ID" value="XM_007703653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SJG5"/>
    <dbReference type="STRING" id="665912.M2SJG5"/>
    <dbReference type="GeneID" id="19131375"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_146302"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608510_0_0_1"/>
    <dbReference type="OMA" id="PKPQWKG"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="99"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="224"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD62485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52541" checksum="2F64550E182D340F" modified="2013-05-01" version="1">MADTEIAAAAASNPAEASQAETALQVESDSKTETKPDAKAADGEEKWELNGKSSEKGAHRNDREDRNGRNSRDNRGGRGGRGGSKGNNRNKKQNQEFDNLPESDDPAEIRAQIEFYFSAQNLATDEHMFKELEGPKNKPVSIHHICTFKRMRRFKPYSAVVEALRNSSDLVVVDDGEYSKPGSEAVKRKEPLVVPAKEGDDEKPPTTEELFYRLRSSSSNSMETSAYVKGFGDAEEAGQIALEQFFRPFGSVMVRKRRDEEGLWKGSVFVEFDSKDSQQQFLVLDPKPKFNGNELTTMGKKEYIMMKCEEKGIKPDWELTEKEKYEKRKKQREANGNFSSSRGNDRRGGGRGRGSNRGGRGGRGGSDRRDNRRDRSPRRRRDRSASNDSIDSGDWNKRRDRFKNGKDDRANSKEEKKEIERDAHGVPVVKDSRTEAEIAASSNKRKAEDDQSGSPKKTKLEIKQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2SK76</accession>
    <name>M2SK76_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_34368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696601.1">
        <property type="nucleotide sequence ID" value="XM_007698411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SK76"/>
    <dbReference type="GeneID" id="19137614"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34368"/>
    <dbReference type="eggNOG" id="ENOG502SAIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021051_1_1_1"/>
    <dbReference type="OMA" id="WHQTFRF"/>
    <dbReference type="OrthoDB" id="2796277at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="196" mass="21254" checksum="44CBE441A2416AD1" modified="2013-05-01" version="1">MSQPHRGVSLSSTVLNPAPIHGVITVTAAELARQTFSKPSNRLPLSARNRISRFTTCSTSAMATPTLTNPSLTAAVCSLEHRVWAALCSSGSDIIPLLSSNPVMIFPGDMILSSVSSPTVHEMLQGPNFRPWKSYTLSHDEVVQLGKDSALIYYRVEAVRDNETFRAICSSAWVLEGSSESLAGEWKIASHQQTLI</sequence>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19">ND90Pr / ATCC 201652</strain>
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    <reference evidence="19" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700607.1">
        <property type="nucleotide sequence ID" value="XM_007702417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SMJ4"/>
    <dbReference type="STRING" id="665912.M2SMJ4"/>
    <dbReference type="GeneID" id="19141375"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_90927"/>
    <dbReference type="eggNOG" id="KOG2553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021971_1_0_1"/>
    <dbReference type="OMA" id="NKAFDCR"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="419"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMD63515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="625" mass="70758" checksum="0F165717BAD4E42F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2SNB1</accession>
    <name>M2SNB1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_42038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445658">
        <property type="protein sequence ID" value="EMD58277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007706012.1">
        <property type="nucleotide sequence ID" value="XM_007707822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNB1"/>
    <dbReference type="STRING" id="665912.M2SNB1"/>
    <dbReference type="GeneID" id="19140149"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_42038"/>
    <dbReference type="eggNOG" id="ENOG502R2RI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005801_0_0_1"/>
    <dbReference type="OMA" id="LQHENEN"/>
    <dbReference type="OrthoDB" id="5572782at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160:SF19">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="47"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="861"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="921"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD58277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1141" mass="124711" checksum="D229DB90DDE7F44B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_165046</name>
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    <organism evidence="3 4">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705292.1">
        <property type="nucleotide sequence ID" value="XM_007707102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SNS2"/>
    <dbReference type="GeneID" id="19132353"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_165046"/>
    <dbReference type="HOGENOM" id="CLU_2157943_0_0_1"/>
    <dbReference type="OMA" id="IAVGWYQ"/>
    <dbReference type="OrthoDB" id="10042947at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025639" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12407" checksum="C941C76F0F041369" modified="2013-05-01" version="1">MSPFSRMARMLLILHSLVNMALGAYSFVNTQEYAAITGVEASDRALQSIGLSTIAVGWYQLIFTLQGNRRMMASMIPLRCGFAAVMSMWDKTPLVLYELCVVWFCLLAIFA</sequence>
</entry>
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    <accession>M2SNT8</accession>
    <name>M2SNT8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_277405</name>
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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            <taxon>Bipolaris</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
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        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD68853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="129" mass="13428" checksum="91D74BAAFCE822F6" modified="2013-05-01" version="1">MSAPTTVLLVVGRCIYHGLISLSLFSSNIFISVSSKTLPYSLSPSCCPAPMASALQKFKLVFFVPPSALGACKTAVFSAGAGRYPGPGGYTEVCFCTRGTGQFRPGDAANPNVSCVGLSIYMCRTKAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP61</accession>
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        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_103417</name>
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    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_007707455.1"/>
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    <dbReference type="AlphaFoldDB" id="M2SP61"/>
    <dbReference type="STRING" id="665912.M2SP61"/>
    <dbReference type="GeneID" id="19129844"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_103417"/>
    <dbReference type="HOGENOM" id="CLU_004184_6_2_1"/>
    <dbReference type="OrthoDB" id="3694075at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF80">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="88"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD58537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="190" mass="20796" checksum="0BBACF334A1FE938" modified="2013-05-01" version="1" fragment="single">MKRSRSSSEGRAAGPPPKKRGLGATTSDVTLPFRGVRNNTSAYLPLDPKVNEIRYVAVDPGEGDAPLSGFLGYLELRGSQTHAPAISYQAVSYCWGEIKDTLGFTLRCARTKEATAKSSQEAWTAQLYQITRNLDALLRALRQPDKHRVLWIDAICIAQDNAVEKTHQVSSMGLVYSSASEVLVWLGEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2SP94</accession>
    <name>M2SP94_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_31801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694111.1">
        <property type="nucleotide sequence ID" value="XM_007695921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SP94"/>
    <dbReference type="GeneID" id="19136526"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_31801"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_4_1"/>
    <dbReference type="OMA" id="FHNMGSQ"/>
    <dbReference type="OrthoDB" id="4050368at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="189"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD69028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="627" mass="68461" checksum="9DECA6E49F428E51" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPB8</accession>
    <name>M2SPB8_COCSN</name>
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        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_36713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699777.1">
        <property type="nucleotide sequence ID" value="XM_007701587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPB8"/>
    <dbReference type="STRING" id="665912.M2SPB8"/>
    <dbReference type="GeneID" id="19138805"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36713"/>
    <dbReference type="eggNOG" id="ENOG502S6DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047453_0_0_1"/>
    <dbReference type="OMA" id="CLQSWRH"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD64135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="312" mass="34902" checksum="27F5AE3E7CC4CE8F" modified="2013-05-01" version="1">MSSSSGFQPMPGWYWPDDVPKHEPSQSGAASADTSSRQQHTDESASGSSSSSQPRSSRRTHWPSRQCRICLETVQPTFNVPSPNLPGFLQSSNVVYEDEAGRLIRPCMCKGSSKYVHDACLQAWRHADPSYGRRNYWQCPTCGFKYRLARLGVGRIIGSVSAQVGLTVLILFSIIFVLGFVADPIINLYLDPWSMLLPWSGHSGSDYSYYYEDESSTWYEHFAKGFASMGVLGFLKVLLASPLSYFRIGGGARGRTTGRDRYEQISWIIILVGVATFLTAIYKGVRSWSRRTLERAGERVMDVQGDDEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPD2</accession>
    <name>M2SPD2_COCSN</name>
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        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_117209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700026.1">
        <property type="nucleotide sequence ID" value="XM_007701836.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2SPD2"/>
    <dbReference type="GeneID" id="19130354"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_117209"/>
    <dbReference type="eggNOG" id="KOG1998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000595_0_1_1"/>
    <dbReference type="OMA" id="LWDNQAF"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="9">
        <location>
            <begin position="645"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="10">
        <location>
            <begin position="1468"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1882"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1939"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1939"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2000"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2023"/>
            <end position="2034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD64155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2070" mass="230112" checksum="2140E738C39862F6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SPS6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_36894</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64315.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SPS6"/>
    <dbReference type="STRING" id="665912.M2SPS6"/>
    <dbReference type="GeneID" id="19138844"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36894"/>
    <dbReference type="eggNOG" id="ENOG502SN8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044724_0_0_1"/>
    <dbReference type="OMA" id="WTLGPIK"/>
    <dbReference type="OrthoDB" id="5206740at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="324" mass="34429" checksum="3FD67CBFF7D8D7ED" modified="2013-05-01" version="1">MMLSTIQPSHPSMPKPYSQSSAMSTMTASLPIIPPPRQQPARPKLSINTEQPRILGKGASLRLDTLSAASPTVRNTYTNAYERPSTAPTLQRPQRPSLSIESDLPAAANTASTPSSASTLSSTLTSASADSATSAIPYKQPHNLVSILSNSPARSILPRKMASSRPMFPAEKHVCFRTPLEEEITTTRYTMAHSDLESSVSTLSTISSVASSTDSDVSATHHSLIVNTSNTSSTTSISPLQLSLQRSTSTFASAESSPRSKGPRAGDKRDSSSSEDESDSCPQTPIAGRRKRTRDWRWTLGPLPSSDKSSSSSASEATTSDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQD9</accession>
    <name>M2SQD9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_210242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694777.1">
        <property type="nucleotide sequence ID" value="XM_007696587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQD9"/>
    <dbReference type="GeneID" id="19134384"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_210242"/>
    <dbReference type="eggNOG" id="ENOG502SI7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057896_1_0_1"/>
    <dbReference type="OMA" id="FDAWPSV"/>
    <dbReference type="OrthoDB" id="5372935at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31879" checksum="11C382BBB5FD330F" modified="2013-05-01" version="1">MARKKKAIDHMVNRMSKLRLVDEQAALAAPPKQPERSKDTGNKDEEEVERQPFRFFDLPYELRLRVYEELLIFPKTIDLDPSNYCTVAPALRLFLTSQRMHDEAARVFYGRNTFRVFPIHGRYINRKHPLLAWFPRKYRVLLTRLELRLGPGFTKPPKCWVVDSRLGLAAVKKVYLLKIFVEIDPASDAVFEGFRVGNNFYTEYCVGLLRGLLSQVPSINDVEFDAYPSVSKSSPLLAGLIEETRLNQKHIAWGPERGWDKIVETDLANVLQKMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SQR6</accession>
    <name>M2SQR6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_312732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699240.1">
        <property type="nucleotide sequence ID" value="XM_007701050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SQR6"/>
    <dbReference type="STRING" id="665912.M2SQR6"/>
    <dbReference type="GeneID" id="19136410"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_312732"/>
    <dbReference type="eggNOG" id="ENOG502S175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106783_0_0_1"/>
    <dbReference type="OMA" id="FDYWMAQ"/>
    <dbReference type="OrthoDB" id="3892274at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="119"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD64620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="226" mass="25635" checksum="62044BAD2AD557D9" modified="2013-05-01" version="1">MDSHSFDYWMAQGNYVVPPHQNTVFDMPPELSKVPSLSGSPVSSTYDQFPAQIQHAYYPQIVDEPMQFGSYPMPMTPSDFGSDHDSPYCSPRPLQHVEPTFGAVHTPAPAERTHTTSGRRRAQNRAAQRAFRERKEKHARDLETQLSILNEKYTKLEVSHSELNAAYEKLRKTIELLTQDNDAEGEDEDGTSIRRRSTNSDTLRKLLEILHGEFKSTTPVKTEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2SR01</accession>
    <name>M2SR01_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="8">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_127652</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">ND90Pr / ATCC 201652</strain>
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        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
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        <text evidence="3 8">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <location>
            <begin position="235"/>
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        <location>
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            <end position="225"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367076"/>
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        <source>
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</entry>
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            <taxon>Pleosporales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="91" mass="10106" checksum="ACF0410348CC0B24" modified="2013-05-01" version="1" fragment="single">RSIQTSREGRISLAIASYRNNPKQSIRALAKAFDIPQSTLHTRIHGTLYSPRVAKIHLQHLLARSGCRALSRTSQSSRQSGLESLEPARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2SRN0</accession>
    <name>M2SRN0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_356192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699473.1">
        <property type="nucleotide sequence ID" value="XM_007701283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SRN0"/>
    <dbReference type="GeneID" id="19138420"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_356192"/>
    <dbReference type="eggNOG" id="ENOG502SQCA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711739_0_0_1"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD64940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="388" mass="43533" checksum="CF2BD394E31DDAA9" modified="2013-05-01" version="1">MSRHKTFIRQCSHHFYDELLGPNAVPVSTISPVTIIDPKRGRDQGKSRYFLDSVYEIHAASVISLSYPTILSFLTDWWIIVNKYLSRNFSFEKDRIVASAGIARAFSYLGRLTYLAGLWNEILPAALLWYVDKKPSWLIRIENLIPNGNPVPYSIWTPEIIADKSAESAAEGKTAPLPPPNPPSWSWFSIPMYKYYQTPFLLADNSLFIRSKALNSPHLGFQFPGHAARHAPDTAAHEFSGAQITLETSVLPVKSNWPADLAAQMQDIASNSSAVPADRRFRWDPELEYYPDDPAGRASPPRDAVYGLLSEVQVVRTAGAKNIQRRLAGLMLVPGLIKGTWRRVGVWKLRVNVRDVLVDAGNIEGVAEKWAGKRVVSGKWERVVLRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2SST3</accession>
    <name>M2SST3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">COCSADRAFT_113999</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698528.1">
        <property type="nucleotide sequence ID" value="XM_007700338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SST3"/>
    <dbReference type="STRING" id="665912.M2SST3"/>
    <dbReference type="GeneID" id="19130244"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_113999"/>
    <dbReference type="eggNOG" id="KOG1459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012965_0_0_1"/>
    <dbReference type="OMA" id="WACPFLL"/>
    <dbReference type="OrthoDB" id="6600518at2759"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMD65355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="583" mass="66217" checksum="AF03C5F7192AF360" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2STJ9</accession>
    <name>M2STJ9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_126333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445651">
        <property type="protein sequence ID" value="EMD60087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007704313.1">
        <property type="nucleotide sequence ID" value="XM_007706123.1"/>
    </dbReference>
    <dbReference type="STRING" id="665912.M2STJ9"/>
    <dbReference type="GeneID" id="19130653"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_126333"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005480_0_0_1"/>
    <dbReference type="OMA" id="CLATTHD"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000051">
        <property type="entry name" value="Putative kh domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="K Homology" evidence="11">
        <location>
            <begin position="231"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="460"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD60087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="1331" mass="143250" checksum="CFA464AA53F05567" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2STK8</accession>
    <name>M2STK8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_139775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698709.1">
        <property type="nucleotide sequence ID" value="XM_007700519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2STK8"/>
    <dbReference type="GeneID" id="19131132"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_139775"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="KEIYGWR"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD65615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="542" mass="59202" checksum="B044EA6F0C43AEB4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SUN6</accession>
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        </recommendedName>
    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2012-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genome structure, secondary metabolite and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Lucas S."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ND90Pr</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD60781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704986.1"/>
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    <dbReference type="STRING" id="665912.M2SUN6"/>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_183745"/>
    <dbReference type="eggNOG" id="KOG2397">
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    <dbReference type="HOGENOM" id="CLU_016834_2_1_1"/>
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    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025823" description="Glucosidase 2 subunit beta" evidence="6">
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            <begin position="23"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="437"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="172"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD60781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697544.1">
        <property type="nucleotide sequence ID" value="XM_007699354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SVX2"/>
    <dbReference type="SMR" id="M2SVX2"/>
    <dbReference type="STRING" id="665912.M2SVX2"/>
    <dbReference type="GeneID" id="19137972"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34964"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="3687090at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-T/H4_C"/>
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        <property type="entry name" value="Histone-fold"/>
    </dbReference>
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        <property type="entry name" value="Histone_H4"/>
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        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="13">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD66445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="103" mass="11370" checksum="9392CDB8AE0C52E2" modified="2013-05-01" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKTFLEGVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2SW94</accession>
    <name>M2SW94_COCSN</name>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702668.1">
        <property type="nucleotide sequence ID" value="XM_007704478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SW94"/>
    <dbReference type="GeneID" id="19133409"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_183345"/>
    <dbReference type="eggNOG" id="ENOG502RGI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023231_1_0_1"/>
    <dbReference type="OMA" id="YKYYAAM"/>
    <dbReference type="OrthoDB" id="3445803at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004026202" evidence="1">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="450" mass="49108" checksum="B3FDB64F5F6C4919" modified="2013-05-01" version="1">MKSSTIASILLSSLTLLEAASTRRVAKGVATVDLSKTSGQAKFLASGWIYGFPDNGTEADTSIPSNYITDIKFGSSRAGGAQTSSRGWIDGYDSYLPRFKSTLSNYRTTRKYNGEFILLVHDLWGADGSNIPRFPGDNGNWTETDAFLTQLVKDIKANNMLDGLILDIWNEPDIGAFWARTWPQFLDYYVHAHNFFKKNLPSTIISGPSMASSPSTNSETWKTWLSTIASKNATPDIYSWHQIGDWSRQPDATIPDFNTLRSSNKLPERPIDINEYAAKEEQTPGCSVYYIAQLERHNLRGLRAHWGSGTGLHDSLADLVFKKSGTGYLPNGEWQLYKYYAGMTGERLATKAAADSRFDVFATKSADGLVKVIAGTRSVKGQYDIQLSGLKGASVSVATYRIDWAGPAGEIVAPVALGTSTVNISSGMITISVDLATNATAYAYEISGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2SWC5</accession>
    <name>M2SWC5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_97475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445649">
        <property type="protein sequence ID" value="EMD61132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703450.1">
        <property type="nucleotide sequence ID" value="XM_007705260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SWC5"/>
    <dbReference type="STRING" id="665912.M2SWC5"/>
    <dbReference type="GeneID" id="19141735"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_97475"/>
    <dbReference type="eggNOG" id="KOG4200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043048_0_0_1"/>
    <dbReference type="OMA" id="HSKQVQI"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD61132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50117" checksum="F37798DF366C26DA" modified="2013-05-01" version="1">MEELEDDVHQDKSIVRVVIDSLLLPLRIATSPALIRTYLRTALLFIASTILFGFAVVAYSSFYYAYIPVRGIVVPVYLQYDHSPVVLHTPTQVSGVPTGKAAKWPYGLANIPGLVDRQKYDVVVELDLPRSETNLRAGNWMIGLEFRGPTTLGQGVKHMLGWDEEWNVEDHSQGGAPGNTAEKVVTDDTTPQTPTVLARSKRPAILTYRSRILEMIYRLMRLPLYLLGWHKESEHVTIKMMESVMFEPGYRNVPSSLRLELRSKLPLEVYRASVHITARLEGIRWLMYRYRILSAILGILSFWGMEMCVLVITWGTFTLLASSFSSVPGDDEEERKEEKKIKAEAGETDPGTPFSETSRTFPTLPSQYPLSYSSSGGGVKQEESESALKDIPVKEEAEADDEDEDFLLKVPLPVGVEREGVFTDSGLGTGLESGVERGAARRRVMKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2SX39</accession>
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        <recommendedName>
            <fullName evidence="14">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_123285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007704660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SX39"/>
    <dbReference type="STRING" id="665912.M2SX39"/>
    <dbReference type="GeneID" id="19130553"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_123285"/>
    <dbReference type="eggNOG" id="KOG1082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020840_11_3_1"/>
    <dbReference type="OMA" id="CDCLEYA"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="246"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="355"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD61526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59273" checksum="4566863DCE451A91" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2SXG3</accession>
    <name>M2SXG3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_39227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702599.1">
        <property type="nucleotide sequence ID" value="XM_007704409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SXG3"/>
    <dbReference type="GeneID" id="19139447"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_39227"/>
    <dbReference type="eggNOG" id="ENOG502SC8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125054_0_2_1"/>
    <dbReference type="OMA" id="SDVWDKR"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="102" mass="11725" checksum="5A2B7DC78DDE722B" modified="2013-05-01" version="1">MLRATSRLLACRITFFTRTPCSLCDDAKAVVHNVKAKRPLEYHEINVMEQGQDKWKGLYEFDTPVIHIDKAGSQETSASSLKLMHRFKEEDVVKLMDQAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYH5</accession>
    <name>M2SYH5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_225024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD61857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702241.1">
        <property type="nucleotide sequence ID" value="XM_007704051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYH5"/>
    <dbReference type="GeneID" id="19134661"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_225024"/>
    <dbReference type="HOGENOM" id="CLU_150141_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD61857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="144" mass="15118" checksum="C12A55BAE2A307F6" modified="2013-05-01" version="1">MRGCVCVCVHYSVCLHSRRRRMYMPTKPGCTTPSLQPQPHPPRSPSAPFDHAPPAPCDPAALPPCASPSSSPSPPPSPPGKPCTTFLNAPFSPIRPCPCTLFAVCCTVCCGSTPPLTSCARQAPIAACSTRPALSLIERHTATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M2SYR4</accession>
    <name>M2SYR4_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="12" type="ORF">COCSADRAFT_34260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696576.1">
        <property type="nucleotide sequence ID" value="XM_007698386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SYR4"/>
    <dbReference type="STRING" id="665912.M2SYR4"/>
    <dbReference type="GeneID" id="19137552"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34260"/>
    <dbReference type="eggNOG" id="ENOG502QUUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032730_1_0_1"/>
    <dbReference type="OMA" id="WSFTQGL"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="42"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="119"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMD67460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="488" mass="53265" checksum="AAC76C47049E9FF8" modified="2013-05-01" version="1">MPVPLPVTQGGASSLSFTQGFLLGQLSIALLIFCFIKFFIFGEPPSADERALHLNSLRRARTLAHQQSYKQLRARANSTSLSLRHKPSRSIIRKGEESMGGPSIATILAKTYYNVKGHQPESLDWFNVLIAQTIAQLRADARQDDAILTSLTDVLNAGSKPDWIGDIRVTEIALGDEFPIFSNCRVMPADDGFWYGPGNAGNEKERLQARMDVDLSDVITIGIETTLNLNWPKPKSAVLPVALAVSIVRFSGTLVVSFIPSSSPPSTPAPMSSPKPDTHQNASQRRPSSSSGAPPHRPTTLAFTFLDDYRLDLSVRSLVGSRSRLQDVPKIAQLIESRVHAWFDERAVEPRFQQIVLPSLWPRKHNTRGGAATTAGADTALQDSDDEDEIAVMDGNGTAPPATSYIPSPISENVTLEERIEAEGQKMREAEIRAGVRNPSSAADGREHRADSMRWRGEPPRGRQSARPKLQSRTTTGIAAGMPGALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZ32</accession>
    <name>M2SZ32_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_147404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702380.1">
        <property type="nucleotide sequence ID" value="XM_007704190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZ32"/>
    <dbReference type="STRING" id="665912.M2SZ32"/>
    <dbReference type="GeneID" id="19131413"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_147404"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_4_0_1"/>
    <dbReference type="OMA" id="GFMLVHL"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004025481" description="Glutathione hydrolase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="407"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="459"/>
            <end position="460"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD62047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="584" mass="62650" checksum="ECBD11C983ACF4FF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZN5</accession>
    <name>M2SZN5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">COCSADRAFT_229422</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702513.1">
        <property type="nucleotide sequence ID" value="XM_007704323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZN5"/>
    <dbReference type="STRING" id="665912.M2SZN5"/>
    <dbReference type="GeneID" id="19134745"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_229422"/>
    <dbReference type="eggNOG" id="KOG0317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041707_2_0_1"/>
    <dbReference type="OMA" id="YCDVVQL"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000395">
        <property type="entry name" value="Putative Peroxisome biosynthesis protein (Peroxin-10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMD62232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="385" mass="42230" checksum="103AF8B653C99F52" modified="2013-05-01" version="1">MAPSPPFAYPFAASPDIIRSHQKDAYFSGVLLEHLSSLLRKLYGARTAHTYLSETRVIGELLYLGLTTLIGNRTLGEEYTDIVQVESETGRLPALGRRAGYIVACILGPYVLGRALPAFRRRIRAKLEANLRWYARQQARAQMGAQEKGEKVQVRRPLGMRVQSYILQNLDTITSPSPVYAVSLATFYFSGSYYHLSKRLWGLRYIFTRQVAEGDNRAGYEVLGVLLVLQMAVQAYLHLHNTVTASSTAAAAAGGSGHPHGTSAIVGGGAEVSLDPNAYSGNNALLFDAATPAVPTAAASDVQKWTHTPPTDKPRYELGDEETMEWIGGGNRKCTLCLEEMKDPSVTTCGHVFCWTCIGDWAREKPECPLCRQACLVQHVLPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2SZS6</accession>
    <name>M2SZS6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Endocytosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">COCSADRAFT_38382</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701607.1">
        <property type="nucleotide sequence ID" value="XM_007703417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2SZS6"/>
    <dbReference type="STRING" id="665912.M2SZS6"/>
    <dbReference type="GeneID" id="19139241"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38382"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040829_0_0_1"/>
    <dbReference type="OMA" id="DWLIPES"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000055">
        <property type="entry name" value="Intersectin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
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    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="139"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMD62451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="400" mass="45088" checksum="C69DD119B5D218CA" modified="2013-05-01" version="1">MAPNRIEQDEIEKYWEIFSSLSNGGTHLDGAQAAPVLKNSHLRDDQLERVWDLADVDNDGKLDFEEFCVAMRLIFDLINGVSVDVPKVLPDWLVPESKAHLVQATRALTGSQPAYETVEDDDDTPGLRDGFDWYMSPGDKAKYEEIYTANRDGHGNITFDSLAGLFDSLEDVPDSDIRFAWNLVNPKARESVGKDAALTFLHILNQRSEGFRVPRSVPPSLRASFEKAHIDYDINSSANSRWAASRDENTASGRKAKFGDAYLTRLGVGDRANSYGARGGKGTDFGGRTTEDWEEVRLKKQLRELEQKMADVEKEVEKRRHGRNTDSKPALVKRELELLLDYKRNVLKELDNDDGGAVKGLGGIREEIETVREQVEGLQAHLESRKAVLEDLRRQIEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0C2</accession>
    <name>M2T0C2_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007703422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0C2"/>
    <dbReference type="GeneID" id="19139246"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38404"/>
    <dbReference type="HOGENOM" id="CLU_2605857_0_0_1"/>
    <dbReference type="OMA" id="HDWALHR"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="79" mass="8654" checksum="A617927B96223690" modified="2013-05-01" version="1">MSSTRSTSTSTPEKDTMSITSSSTMTSTKSLLRSLLPSKRDSSATKTEAARSKATETPAEKVERKLTKAEALHDWALYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2T0E9</accession>
    <name>M2T0E9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">COCSADRAFT_121554</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="KB445646">
        <property type="protein sequence ID" value="EMD62661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007701981.1">
        <property type="nucleotide sequence ID" value="XM_007703791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T0E9"/>
    <dbReference type="STRING" id="665912.M2T0E9"/>
    <dbReference type="GeneID" id="19130494"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_121554"/>
    <dbReference type="eggNOG" id="KOG2803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031246_0_0_1"/>
    <dbReference type="OMA" id="QCKYINA"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMD62661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="486" mass="55086" checksum="594074C0FB9BE340" modified="2013-05-01" version="1">MQRRHSARGEWIPTEGQWPVDPQHDMPVSDDRIWVDGCFDFAHHGHAGAMLQARQLGTELYVGVHSDEAILENKGPTVMRLDERVTAVEACRWATKAVPRAPYVTSLPWITHYGCQYVVHGDDITSDSDGRDCYRYVKQAGRFKVVKRTPGISTTDLVGRMLLCTRSHFIPSLDKRLSGEEGPGDEAERTKAGQEMLQRIKDYATDASGRAPGCDVWYWHASRPVKLRRTTTSAVTSPTRPDHPRQESTASQVGPVREEKGKFNQIVQGKGLKEGQSVVYVDGGWDLFSSGHIEFLRSVTQCEEDRARENGWFTEEAKLERIQKTGEDYGPVFLIAGIHDDEVINHWKGINYPIMNIFERGLCVLQCKYVHATIFGAPFSLSKAFLHALPYSSPLTIYHGKTTFMPLQFDPYAVPKAMNIYCEIGDHGFQNVNAAEIVARIMKGRALYEERQRKKGEKGITEDAEKLRQEMEREQRRREVEGQFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2T1F9</accession>
    <name>M2T1F9_COCSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_349803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695981.1">
        <property type="nucleotide sequence ID" value="XM_007697791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T1F9"/>
    <dbReference type="GeneID" id="19137981"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_349803"/>
    <dbReference type="HOGENOM" id="CLU_013929_15_4_1"/>
    <dbReference type="OMA" id="GAIRCEP"/>
    <dbReference type="OrthoDB" id="3776271at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD68355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="88" mass="10014" checksum="D126594FC8B4F569" modified="2013-05-01" version="1" fragment="single">HQDSLLALIIAAINQLKKGAEVMILSAELMRDRIATLKRANIVVLERRRRKKKRIQKRGVLTKGAGEDILAQREADEQITREERQGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2T3C9</accession>
    <name>M2T3C9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445644">
        <property type="protein sequence ID" value="EMD63731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700435.1">
        <property type="nucleotide sequence ID" value="XM_007702245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T3C9"/>
    <dbReference type="STRING" id="665912.M2T3C9"/>
    <dbReference type="GeneID" id="19138995"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37497"/>
    <dbReference type="eggNOG" id="ENOG502S8W8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_1_1"/>
    <dbReference type="OMA" id="RVMEYDW"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD63731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="230" mass="24741" checksum="924DCD481F5EE9D1" modified="2013-05-01" version="1">MPQFKVAIYLYPQADILDFSGPAEIYSHSDTLDENATFPFDVTSFAHSSPVVSASPALVYQPNKTFADIVDQITDYDILVIPGAHDKTITDLIATEAGKQLLSLIQKFAAAKPRAETGKRFLQSVCTGSLLLAASGVLAGRTATTHHLSYDLLKTIADEAAGGESKVNVVRQRYVDAGTTDGGVRIVTAGGVSSGIDATIYVIEEIFGKERADWVAEVAEFERREKAWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4R1</accession>
    <name>M2T4R1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_322848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T4R1"/>
    <dbReference type="GeneID" id="19136718"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_322848"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OMA" id="WSSGKFN"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD64241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="483" mass="53852" checksum="5889FD4E3425A448" modified="2013-05-01" version="1">MQDTKKDHAVMMERAQTHDDELIKPIPQVDKIDYSGAHEKTDPREIALVRKLDKWIMPMLWSMYWLNYLDRNAIALARLDELEEDLNLSSTQYQTCVSILFVGYLLGQIPSNMLLNRVRPSRYMGVCMALWAIVSALTALSKDFTGLLLTRFFLGITESPYYPGAVYLLSSFYTRKEVATRIAILYTGNILATAFAGLIAAGIFHGLGDVGGISGWKWLFILQGAVTFVIAIIGYFLLPDFPHNTWWLTQEERDLATNRMALDTVGNQGETSVWAGFRQAGKDPMVWIFAGMAHMHLAANGFKNFFPTVVKTLGFNRTITLALTCPPYLIAGAVTIAVSWSSGKFNERTWHITISKAVATFGFGLACAEIGVAGRYVAMVIFTIGTYGVNSLILGWCGSTCGQTPEKKAVAIGIVTTVMNASFIWTPYLWPKSDEPRYIIALSSSAAFSVMTAMLAWVAKVQFLRKNKKIREEDSDAQNFYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2T4W0</accession>
    <name>M2T4W0_COCSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_320360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_007701749.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="19136615"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_320360"/>
    <dbReference type="HOGENOM" id="CLU_181663_0_0_1"/>
    <dbReference type="OrthoDB" id="10359069at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="99" mass="9965" checksum="611ED9A9C8E6BDAD" modified="2013-05-01" version="1">MPSTSYALGTSFSPCHHPTLPLLHTASTTRACSTSPVPGHSHPSGCTLLSIARSTAPACSAAGPGLARRSRPPVASPSGDCPNFLSYGGNTASCNRMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2T505</accession>
    <name>M2T505_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_32207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694229.1">
        <property type="nucleotide sequence ID" value="XM_007696039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T505"/>
    <dbReference type="GeneID" id="19136680"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_32207"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="OMA" id="FMTMKAA"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD69505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="288" mass="32300" checksum="4CDE628CF11B6E87" modified="2013-05-01" version="1">MAALTIESRYLMPSGYKIPVLGYGVYQTPAEIATEVVQHALKVGYRHVDSAVAYRNEAPSAEGMKKSGIPREDLFFTTKIPPKDMSYETAKKHIDSTLEKTGFDYIDLYLLHSPYGGKANRIGAWKALVEGVQAGKIRSIGVSNYGVHHLDELETWIKETEEKEGKGKGGVISVNQVELHPWLARPDITEWCKKRGVLCEAYCPIVRATKNDDALLKSLAQKYSKTPSQILLRWSLQMGFVPLPKSVTKSRIEENAQIYSFELSEQDMKSLDTGLYEPCSWDPTVSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5F1</accession>
    <name>M2T5F1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_131645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694908.1">
        <property type="nucleotide sequence ID" value="XM_007696718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5F1"/>
    <dbReference type="STRING" id="665912.M2T5F1"/>
    <dbReference type="GeneID" id="19130824"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_131645"/>
    <dbReference type="eggNOG" id="ENOG502SP89">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299698_0_0_1"/>
    <dbReference type="OMA" id="MRAHIFW"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD69640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="239" mass="27540" checksum="A48B938908A3835B" modified="2013-05-01" version="1">MAKLEPKGPLGKAEKPKFSHFLTSPLVTVTIAKSRTFYLHFDLLVAESDMFSNSLTGRFKEAEEKAIELEDEDPETFGFFVEYLYRNQSILSRDVAHYSEYVTLARLYVMGERLMAPRFQAYTLWRFVQTLGTNTHISEESVCELLRVACEEIAERVREDPMRAHIFWYAGAQISKLQKSSLFRQLLCDTPDLGSYLCLWVGQGQPKKPDVPNELKYQKFAPESEHSLQRYSEASSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5I1</accession>
    <name>M2T5I1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_89781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700263.1">
        <property type="nucleotide sequence ID" value="XM_007702073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5I1"/>
    <dbReference type="GeneID" id="19141314"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_89781"/>
    <dbReference type="HOGENOM" id="CLU_160178_0_0_1"/>
    <dbReference type="OrthoDB" id="3797485at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="76" mass="8136" checksum="89EAED18DDCA0EA6" modified="2013-05-01" version="1" fragment="single">AGLNLNLFAALSGAFSSKSKKSTRQEANGDSVTEEERWDRGEASGIARAQGSAYAAANAEEREVKAKRVDHLGIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2T5I8</accession>
    <name>M2T5I8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_37081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699863.1">
        <property type="nucleotide sequence ID" value="XM_007701673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T5I8"/>
    <dbReference type="STRING" id="665912.M2T5I8"/>
    <dbReference type="GeneID" id="19138891"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37081"/>
    <dbReference type="eggNOG" id="KOG0836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045161_0_0_1"/>
    <dbReference type="OMA" id="VACIEDH"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD64501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="269" mass="29494" checksum="65DBDD3F6A05086E" modified="2013-05-01" version="1">MSRTAALSSFIDSAPPGELADVTKAIKSILGNDSVQNELSPAFQKYNEEQFATTKLPGGSTEVLVSQYNSLGDGRYYDIDTQSSFDFDHVTGKASAVQSYVVETSNDDLLKSLNKALSTHAAEHYPKSSHGVYPIPSSSNFAIITVANKYSPTNYWNGRWRSSYTYDSSSGSITGSIKVDVHYYEDGNVRLLTTKEVSVNGSGASGPEVVRKIAAEEKKYQEDLNKAFASLSEGAFKSLRRQLPITRQKIEWEKISGYRLGQDIGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2T938</accession>
    <name>M2T938_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">COCSADRAFT_305722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698591.1">
        <property type="nucleotide sequence ID" value="XM_007700401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T938"/>
    <dbReference type="STRING" id="665912.M2T938"/>
    <dbReference type="GeneID" id="19136268"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_305722"/>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010668_1_0_1"/>
    <dbReference type="OMA" id="GFMNMFA"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="272"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="875"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="939"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMD65447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="966" mass="107045" checksum="73F2329727E02FCD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2T9F6</accession>
    <name>M2T9F6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_25175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698258.1">
        <property type="nucleotide sequence ID" value="XM_007700068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2T9F6"/>
    <dbReference type="GeneID" id="19135234"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_25175"/>
    <dbReference type="eggNOG" id="ENOG502R0XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="OMA" id="GGASQWH"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="92"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD65547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="385" mass="43354" checksum="7D01C9FA1CC1B8FE" modified="2013-05-01" version="1">MAPIAIPVAEHIKENDTVQPRKDTLKLPEPARKRLEKAGIDLSNGYPYRPAKPLYLDDVYKIRDYDREHIDPGSRADPEKKALLSAAKKVIHLTAHIGTEIVGLQLKDLTEQQKDELGLLIAERSVVFFRDQDLSPQQQKKLGEHYGEIEVHSVKPQVPHVPGVPGITVLWPDLQATEVPASFRKTGGASQWHTDLVHERQPAGITHLHNDTIPKVGGDTLWASGYAAYEKLSPEFRKIIDGREAVYRSAHPYLERDNPSAGPKHVERVHPLVRVHPATGWKALWVNRAFTVRIVGLDKAESDVILNYLFDVYEKSVDIQVRFRWTPGTSALWDNRITIHNASWDYEGSEPRHGTRVTSLAEKPFFKADAPTRRQALGLAGPEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TAC5</accession>
    <name>M2TAC5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_137444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697704.1">
        <property type="nucleotide sequence ID" value="XM_007699514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TAC5"/>
    <dbReference type="STRING" id="665912.M2TAC5"/>
    <dbReference type="GeneID" id="19131050"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_137444"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067602_0_1_1"/>
    <dbReference type="OMA" id="GISFPIM"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD66141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32888" checksum="623357F8B9329746" modified="2013-05-01" version="1">MASVQQQANGNGNGAAVRPPRPEHEGPQENIFLFIPNLIGYSRVFLALTSLYYMPLHPRTCTLLYSVSCLLDALDGYAARKYEQSTKFGAVLDMVTDRCTTTCLLVFLAQAFPRWSIVFQLLISLDLASHYMHMYATLSMGGSARSHKNVDESRNWLLKQYYSNNKVLFTLCAMNEVFFIALYLLSFSSPYLSPTLFSDSKNPSSLQPGSPAAPEPSMFFASPFSAAAMEMARANKMDSTVPWIFMVVALPFMLIKQWINGVQMKTASQWLAEGDREARRLAGLPRRNGSKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2TC40</accession>
    <name>M2TC40_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_35246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697614.1">
        <property type="nucleotide sequence ID" value="XM_007699424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TC40"/>
    <dbReference type="GeneID" id="19138155"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35246"/>
    <dbReference type="eggNOG" id="ENOG502SFRS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055312_1_0_1"/>
    <dbReference type="OMA" id="GYMRFPE"/>
    <dbReference type="OrthoDB" id="5399926at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0749">Sporulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="309" mass="32836" checksum="BBFBD2ADDFD4E3A1" modified="2013-05-01" version="1">MPRGSRRGRGRHQNSSRVTASRRVTSNSPSTSQSRTSSGHTTAHNTDSQTPLRRSARIAELLNGQSDRQLADTACSMADVARPRALGGRSHRPVHHPGSARTSGNSRSGRLSLSPDEIRYAMDIVVQPPRTAQVGQTIPGSIIVRLRTTNADADDAIADSTNLVAVAALVPASSLSDSPDPSALNTLLSGRIFDTVHPFSDDEADGFIASMDMADPNGVGYMRFPELTIRQAGTYRIRITLIRIRNSASDPPVTSAGNGLAVHVVDSNPIVVSGGGSATSTASRNGGDDIDDGGWLEVLRSIQDRRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TC97</accession>
    <name>M2TC97_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_138023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445640">
        <property type="protein sequence ID" value="EMD66447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697935.1">
        <property type="nucleotide sequence ID" value="XM_007699745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TC97"/>
    <dbReference type="GeneID" id="19131074"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_138023"/>
    <dbReference type="eggNOG" id="ENOG502S2R7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072123_2_0_1"/>
    <dbReference type="OMA" id="RDLYAKW"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336:SF1">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT C_ THIOL SPECIFIC ANTIOXIDANT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="198" mass="21929" checksum="6C9AB6E60CF89FA2" modified="2013-05-01" version="1">MTWQRELSSWMSPPRLKTADAPAVGQKAPSLPSLEGSVQNGKPTIISFLRHCGCPFAEKTFLDLRAIAPTNLDVHFVAVSHSNQESTDKWLASLPDPSRNKQPNLYVIVDAERETYAAWGLDTSGVWHVLASMPSVLKLANKEGIKVRPTESGSRWQTAGDFAIDGEGIVRWSRKNERADDMPDFKEGLDALLKDRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDH1</accession>
    <name>M2TDH1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">COCSADRAFT_157686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696980.1">
        <property type="nucleotide sequence ID" value="XM_007698790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDH1"/>
    <dbReference type="STRING" id="665912.M2TDH1"/>
    <dbReference type="GeneID" id="19131842"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157686"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_20_0_1"/>
    <dbReference type="OMA" id="EAENVGW"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMD67286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="213" mass="22694" checksum="666748E6661A053D" modified="2013-05-01" version="1">MAGLDEDTIDDILYLARTNEATELDSFLSELSAKAKQSKAELLTAAIDPYSKNSALHYAAANGHNDVIKLLLSTSTDKPRPEFLNAVNEAGNTPLHWAALNGHLESVKLLINSGADVTIVNQAGHDAVYEAEINDKNDVVDWLLGAVEELEKGIGQTGEGSAGESADEDMGGVNMDSAEGDKTSPQQTVGSAVENARQQMEHLNTQNSMAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2TDS3</accession>
    <name>M2TDS3_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">COCSADRAFT_157781</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697059.1">
        <property type="nucleotide sequence ID" value="XM_007698869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TDS3"/>
    <dbReference type="STRING" id="665912.M2TDS3"/>
    <dbReference type="GeneID" id="19131850"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_157781"/>
    <dbReference type="eggNOG" id="KOG1147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="OMA" id="CPVVDSH"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="128"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="435"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="551"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMD67391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="644" mass="73035" checksum="45FBB52221B3B2BD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEA1</accession>
    <name>M2TEA1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_34353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696597.1">
        <property type="nucleotide sequence ID" value="XM_007698407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEA1"/>
    <dbReference type="STRING" id="665912.M2TEA1"/>
    <dbReference type="GeneID" id="19137606"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_34353"/>
    <dbReference type="eggNOG" id="ENOG502QVP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054969_0_0_1"/>
    <dbReference type="OMA" id="FEAQFKP"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32807" checksum="2F7F2362DE91E532" modified="2013-05-01" version="1">MAPALGKRKRVTRAELEQESRSPSPSSGSSDDSGAEDLQAVFRRAFEAKFKPLPTDPKKLKIEEPPVQKDEEEDEEESDWSGISDNENDVEVIEYHDPHRELDDTERAEMKAFMSSKPPTSASKSTSTSLSQKRNKKTEDTDTTEATNLKNDLALQKLLRESHLLSTSSSGTSTPNTLTTTGVDRHKSMDLHLQSLGAKSSIFTQKKMPMAQRKHMELKARTTEAKRRADAREAGIVLERENKKSTGKKVEKKRERGVGGPSIGKFRGGTLSLSKKDVRSITGGGGAKGKGKGKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2TEC5</accession>
    <name>M2TEC5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">COCSADRAFT_110510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696838.1">
        <property type="nucleotide sequence ID" value="XM_007698648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TEC5"/>
    <dbReference type="STRING" id="665912.M2TEC5"/>
    <dbReference type="GeneID" id="19130126"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_110510"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1622878_0_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMD67097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="164" mass="18553" checksum="11D47E862BC1CE55" modified="2013-05-01" version="1" fragment="single">MHEYGIAHRDIKVENIMVARDGTVKLIDFGSAAVSRNLLTGARIGSWANWIGTPITMAPEVHGERFFDMEKADVWSLAVVFVRLWLGVYPWEPEMILGGLEENEAFGVYTEEMRDERACGESEDEDRLLCQIPLEKARVVIAAMLELDPMRRSTLPMALNSAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2TGL5</accession>
    <name>M2TGL5_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_349844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696006.1">
        <property type="nucleotide sequence ID" value="XM_007697816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TGL5"/>
    <dbReference type="GeneID" id="19137983"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_349844"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OMA" id="WMEMRMA"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD68386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="511" mass="58651" checksum="9636BC69E4BA59C7" modified="2013-05-01" version="1">MHDLLNQTVEVFLVYSASGSRSLKALYTNADVKIRKTWKRSYTEFSSYIEHQLTMCYVQIRVEVDHLLLPGLVFSSLFFLLLTFYQGIGPTVVSYVAFWGTLSLWILLYHAFWHPLRHFPGPFGAKLSKLWTVKQAWDSRWHWHRVQQSLRKEYGDYVRTGPREISIYDPSAIQPLLGFSSMTTKGPFYDVMEKSLRLNRDKVFHHQRHRVWDNGMKESLSTFSPLVEAFIDKLLAQLHKQNGEPTEPLHYCSYYSYDVMSKLAFGESIGFLEGKQSEVEASILNTFNSSSSAMGLMLMDTLGVVISIAGPMKEWQDWSVSQMRQRIARTDGNTDFVGHLIKNTPNDKAGLELLYGESRLIISAGSETTSTALTFTLMQLATNPKYVDAIRKEFRDCVSFNCQRPLPMLDAVIQENFVKPDEFLPERWTSEPELVLNKNAFIPFSIGPYNCVSKTLANMKLQIVIARVVNEFDIRLPDGFVAEQYWDGIRDQFTAGPPESQSFFCYISELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2TI71</accession>
    <name>M2TI71_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitin deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_33323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="4"/>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695513.1">
        <property type="nucleotide sequence ID" value="XM_007697323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TI71"/>
    <dbReference type="STRING" id="665912.M2TI71"/>
    <dbReference type="GeneID" id="19137134"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33323"/>
    <dbReference type="eggNOG" id="ENOG502QUGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_3_0_1"/>
    <dbReference type="OMA" id="PNNYFRP"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10958">
        <property type="entry name" value="CE4_NodB_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF137">
        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="78"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD68407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="274" mass="31270" checksum="73B817758C2CA601" modified="2013-05-01" version="1">MPRFPLRIFRLPYTRAARRRRMYTMLTAICVVITFILPFYVIYKPPNLLIRYFQQKWPDVLWHVPASTLRRNGEEVDKVVALTIDDAPSEFTLDILKVLGENEAKATLFVIGGQVGGRETILQHAAKAGMELGNHAMHDEPSRSLTPAVLEAEVRQVEGFINGTYDAVNLPHPPRYFRPGSGFFSTRMRRQIKEMGYQMVLGSVYPHDPQIAYPSVNARHVLSMVRPGSIIICHDRREWTVVMLRKVLPELKRRGYRITTVSGLLEAAGRNKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJC7</accession>
    <name>M2TJC7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_341187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694668.1">
        <property type="nucleotide sequence ID" value="XM_007696478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJC7"/>
    <dbReference type="GeneID" id="19137460"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_341187"/>
    <dbReference type="eggNOG" id="ENOG502SZ82">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077197_0_0_1"/>
    <dbReference type="OMA" id="AKDRCWF"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD69301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="328" mass="38023" checksum="05B6967846F19972" modified="2013-05-01" version="1">MATNDNTPICPDWVFLNNSNVHVAKDRGWFKTYTHFTSQIKSSLFCSPRYLPVLGVGTVEIPTKRTPSRHGVSGYGYLHLKQVLHVPDFICNIIGSSNLISDGYDGKNIAYFNRHVPLYSIRLRNRPEGPKLGPHVLRKNGMYLISCYWVHSEEQKCYWEPSEEQRWLEHQAGYYVDYLESESASSTGASSPAIDTNPPYKKAEKRFLESNWDDEFTFLINHGLDIYEDEDREKGRLILRELMHEEGLDGESANEEESDDEEESDADFWDRAEFTSEQLEWIETHYDNIDAFMRSYGMCCMDYFRCIDAKEIVDAFLSEEQLSHATNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TJW2</accession>
    <name>M2TJW2_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">COCSADRAFT_78413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD68987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694450.1">
        <property type="nucleotide sequence ID" value="XM_007696260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TJW2"/>
    <dbReference type="STRING" id="665912.M2TJW2"/>
    <dbReference type="GeneID" id="19140659"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_78413"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047877_2_0_1"/>
    <dbReference type="OMA" id="SGYKFVH"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMD68987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="334" mass="37238" checksum="68A129D498E19067" modified="2013-05-01" version="1">MQRPNYSNPPPAHSPPLHHPIPQHVSTVPQLRSPPPPPSQPQSGYGYGQQGGGMPPQQGGYNMHPSFGGFINDPTAQLGFQMGKSAVDAGQQYVEQNIGRFVSVSALRHYFNVTNSYVLTKLRIILFPWWHRPWSRQQRHTSDPAASSTALLYQPPREDVNSPDMYIPIMALVTYILLSTLLAGLRGAFHPELLGYTATVAISVTLLEILIIRTGTFLLAISSSSQLLDLVAYSGYKFVHVIVSLLLTHFASWLGFGGTMVNWIIFLYCFSANAFFLLRSLRYVLLPDQTGQGNFGGPAPGGYPAKNQKNRRTQFLFVYSYIVQFGFMMWLTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2TLU0</accession>
    <name>M2TLU0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">COCSADRAFT_166623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694913.1">
        <property type="nucleotide sequence ID" value="XM_007696723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2TLU0"/>
    <dbReference type="STRING" id="665912.M2TLU0"/>
    <dbReference type="GeneID" id="19132461"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_166623"/>
    <dbReference type="eggNOG" id="KOG1784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_8_1_1"/>
    <dbReference type="OMA" id="AACDQTT"/>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
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                <person name="Lawrence C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Wu D."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
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                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
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                <person name="Lindquist E."/>
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                <person name="Ciuffetti L.M."/>
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            <dbReference type="PubMed" id="23357949"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ND90Pr / ATCC 201652</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="371" mass="40089" checksum="BD34EBF9F318CFA9" modified="2013-05-01" version="1">MSRPTVTVVSAKGEVTQDTIPVPNVFKAPIRPDVVHAVHTGMNKNRRQPYAVSEKAGHQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNMCRSGRMFAPTKVWRKWHQKINLNQKRFATASALAASGSPALLLARGHAISTVPEVPLVVSSTAFADAAIKKTSAAVALLKAVGAGADVEKARNSRKLRAGKGKLRGRRHKQRRGPLVIYNPDEDGKELVLAFRNIPGVETSSVYSLNLLQLAPGGHLGRFIVWTSSAFSALDKVYGSTTEPSALKKDFLLPSPMMVQPDLSKIINSSDVQKVLRPVRGGAVTKRSHTQKKNPLKNFQVQLRLNPYAATFAKEKLGQKKIEAGKAEPAADTFYELLQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2R354</accession>
    <name>M2R354_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">COCSADRAFT_233570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445648">
        <property type="protein sequence ID" value="EMD61634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702928.1">
        <property type="nucleotide sequence ID" value="XM_007704738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R354"/>
    <dbReference type="STRING" id="665912.M2R354"/>
    <dbReference type="GeneID" id="19134826"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_233570"/>
    <dbReference type="eggNOG" id="KOG3108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051033_0_1_1"/>
    <dbReference type="OMA" id="SFGNKRY"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="7">
        <location>
            <begin position="78"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="8">
        <location>
            <begin position="171"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD61634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29010" checksum="2C46CD9721440117" modified="2013-05-01" version="1">MNYNNYETSYTSYGAGGGGGGGGFIPGEGGSTQSPGGRQNQIQDSIRPVTIKQIIDAQGEAGSNDTFKIDGTVISQLTLVGQIRNISNQTTNTTYRLDDGTGSIEVKQWVNPETVDHSSLAKAKLVEGAYCRAWGKLKSFNDRKSVGATIIRPIEDMNEISYHLLEATAIHLYFTRGPPGQAGGATTNEAGKQQAIEGGYGGAELAGYSQAAKRVFNFLREVEQSNEGVNQYEIASKLGIDAADVAKAGEDLLAGGLIYTTLDDQTWAILDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2R4E6</accession>
    <name>M2R4E6_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_38851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
        <property type="protein sequence ID" value="EMD62049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007702127.1">
        <property type="nucleotide sequence ID" value="XM_007703937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R4E6"/>
    <dbReference type="GeneID" id="19139354"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_38851"/>
    <dbReference type="eggNOG" id="ENOG502SIHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043294_0_0_1"/>
    <dbReference type="OMA" id="GSWHVSW"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="382" mass="40447" checksum="F720C8572D448703" modified="2013-05-01" version="1">MASPATVPFTSVDTTTRQLTKDEVESPSISSANALARYEYEAGHANATTGTKILMVEWEDDDTTRGVRGDWHISWDGSTRVLPANDQSANDVHRMYFLLPPGVAVPTSVTLTLRPQDGTRAPVVWHTNPLPALFPPELGASARAAGKKGVLHTIWAKKRLQVLQKEIEAESRTNVEGVGLLMAVQEKEWIESTFGVNAKPAGLSISLGEPVLAPMKAPSSPRSPGGGRLMDKLAGLRLGTSEKDLSPSNSMQGFSNPLSPESSDIAISSFAVFKGANPASLAAKPPQPPQVQPIDPPRRIAAQAPPQFITEQQSAGMGSLNALSGPAPIFQSRGPLGSADDDDKDDGLFALPISPRSPEVGKSPFSFSASDTAPFLKEESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2R770</accession>
    <name>M2R770_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF924-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_37731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445645">
        <property type="protein sequence ID" value="EMD62839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007700973.1">
        <property type="nucleotide sequence ID" value="XM_007702783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2R770"/>
    <dbReference type="STRING" id="665912.M2R770"/>
    <dbReference type="GeneID" id="19139067"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37731"/>
    <dbReference type="eggNOG" id="ENOG502S80R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065010_0_1_1"/>
    <dbReference type="OMA" id="NWFYMPL"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD62839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30668" checksum="3E44937108A3AC05" modified="2013-05-01" version="1">MSTSSAFKLDPSLFNRTLYDRVISTWFPGVDTSGQELDMSVVKRWFMATPAERVAFDTQCREAFSPALEAIGPNKYPDATAHPFLDELRRIAERSGDANSEEAVWTALSMTLLLDQIPRNIYRTNSGLRFVYNHYDHMAMHLVRTLLSSESPIPRPDLHPVFRLSSPHRMWFYMPLIHSEDVADHDLVSGIVYELEKELASLEGYKGTKMFIEGYSKSASEHRDILDRFGRYPHRNGALGRESTEEEKRFLEEGGATFGVAQEKKEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RBQ6</accession>
    <name>M2RBQ6_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">COCSADRAFT_36853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699809.1">
        <property type="nucleotide sequence ID" value="XM_007701619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RBQ6"/>
    <dbReference type="STRING" id="665912.M2RBQ6"/>
    <dbReference type="GeneID" id="19138837"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_36853"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OMA" id="PVMKYHR"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMD64279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="262" mass="28074" checksum="44ED6B9D26B707F4" modified="2013-05-01" version="1">MGPYQGGQAQYLRVPFADFNALKLPQGTEHEADFILLADIFPTGWHGLVLSGFKSGESVAVFGAGPVGLMAAYSGVLRGASKVFVVDTVPERLQAAEKIGCVPIDFKKSDPVEQIIKLNGGMVDRAVDAVGYQAVDASGSTEKPNIVLDQLIMVTRPTGGLGIPGLYVPADPGAPDEQSKKGQILISFGKLFEKGLHLGTGQCNVKAYNRYLRDMIVSGRAKPSFVVSHEINIEDAPTAYEKFDKRIEGYTKVLIHPNGALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2RC24</accession>
    <name>M2RC24_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate esterase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_26548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699725.1">
        <property type="nucleotide sequence ID" value="XM_007701535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RC24"/>
    <dbReference type="GeneID" id="19135514"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_26548"/>
    <dbReference type="eggNOG" id="ENOG502SNA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_0_0_1"/>
    <dbReference type="OMA" id="HYGDPIC"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024701" evidence="3">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD64394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="351" mass="36390" checksum="E8236DBE176FA930" modified="2013-05-01" version="1">MRLGLVSIFLALSGSSLVLAQERCDAPYPAVYCNTTSILSFNSDACKPFHIFVVRGSDEPYPGRLGNLTQQVCSAIGGTAKCGYEDVEYPAKSSAWSKTSWCDSATKGAKNGQQQMRMYSEKCPDSKLIVLGFSQGGSVAQDMLGGGGGPTFECEQGDNPGLDASVAPGANVVAAVTFGAVSRSRNQNFTVGGGKDFDGTRARTPSQLANLTQYADVLLDYCHYGDPICAVGSEPQDVTEHLNYFVKHNAEVTKWVAGMAKASTGDVSVRPSKPVVVQAAPTSTQNVAAKPIKTGAPTTTSTAELAPVVLSSVTDGAAAAEQTGVANAAAGTVRVVLGYLTVLGAVVVMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2RCA7</accession>
    <name>M2RCA7_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_37048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445643">
        <property type="protein sequence ID" value="EMD64464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699854.1">
        <property type="nucleotide sequence ID" value="XM_007701664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RCA7"/>
    <dbReference type="STRING" id="665912.M2RCA7"/>
    <dbReference type="GeneID" id="19138882"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_37048"/>
    <dbReference type="eggNOG" id="ENOG502SZUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093909_0_0_1"/>
    <dbReference type="OMA" id="RFCSHAV"/>
    <dbReference type="OrthoDB" id="5387413at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="244" mass="28039" checksum="1161D9EE24ADA28C" modified="2013-05-01" version="1">MPTAVHAKPAVAKKERVVGFYEDPVISFCRPVNTSESWAAYHFEMHARKCAHCHNAYEVHRNHERLCDVGHGLAQDVARYIYHKSGATYSTVEENNKLVRVEIPAGYVEVCSLLKAIERSLRHRSRRPFVSMDRSYYVAPRSSPPPASPPRRSNTVKVEQEPKIKSARPRTDDIVDWPQHTVTTTTTKAKRPLSEISNTPNAKRGSLYEEDLAKQRRNAKHYAVEVREPTNRDIREQRSSGYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2RCV0</accession>
    <name>M2RCV0_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_355746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445642">
        <property type="protein sequence ID" value="EMD64619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007699239.1">
        <property type="nucleotide sequence ID" value="XM_007701049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RCV0"/>
    <dbReference type="GeneID" id="19138390"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_355746"/>
    <dbReference type="HOGENOM" id="CLU_1722037_0_0_1"/>
    <dbReference type="OrthoDB" id="3694013at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD64619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="163" mass="18142" checksum="78F48CEE93E786CC" modified="2013-05-01" version="1">MTYQQPLPCNIAVSDRCLPTPPVRLLYPPTPPSAALSTHSPSLILLPKSNTLSPLIGAGRYTYIYILVYNRYYSLTKVALMCAVAYDLHTYLHQSTWPSSRPQPYLRPSAAFCCDYARLLAEKSNFALGKQDRSGDVQPSIEPSGLWPQPFPSPGKPIRFQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2RF91</accession>
    <name>M2RF91_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_35488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445641">
        <property type="protein sequence ID" value="EMD65434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007698323.1">
        <property type="nucleotide sequence ID" value="XM_007700133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RF91"/>
    <dbReference type="STRING" id="665912.M2RF91"/>
    <dbReference type="GeneID" id="19138322"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_35488"/>
    <dbReference type="eggNOG" id="KOG3801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120076_0_0_1"/>
    <dbReference type="OMA" id="YTTDKLV"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD65434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="113" mass="13279" checksum="955DF4BF78332B20" modified="2013-05-01" version="1">MSLAQATKGDVAYQVRSLYRSLLRQSNQFAAYNFREYAKRRTRDAFRDNKDVKDERVIQEMVQKGLSELQMLKRQTVISQFYQIDRLVVEGGKEGKQKGDRSDIVRVKDQGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJJ5</accession>
    <name>M2RJJ5_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoamyl alcohol oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_82403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696686.1">
        <property type="nucleotide sequence ID" value="XM_007698496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RJJ5"/>
    <dbReference type="GeneID" id="19140892"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_82403"/>
    <dbReference type="eggNOG" id="ENOG502SM3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023307_1_0_1"/>
    <dbReference type="OMA" id="QSQCWNF"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7029" evidence="1">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="2">
        <location>
            <begin position="192"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42313" checksum="D0F910408E0AA35A" modified="2013-05-01" version="1">MVPTKEIILGYAAEGMSALVDVAMKQPTVVLEEVAGITSVKCTDSAVSMIFSDTAAVKAASAAWPKSNFIIITYSPDGGCNTADERGFYTVSAISFDEASFTATASGQRSALDEQSEDAVVEFDTITAPAKRDLQTSFSGEINGTLIDTGNLKIVVDQAKFESNIRIKGGFRFNFLKFKSSKMYLDIDYSGLVNLNVSTTVAASFSSDMYKYQPLSASVSAFSIPGILDVGPIAKFGLGVEFAASGTVDASLGLHSEIVNGQVHLDLLDSNKTSSSGWKPETSVSSDVSAEVSLQLNPYLDLNLALGIRVFKGVIDLTTGVEVKPQIINAFSADLNFAYASSSGITFTKPDTATCPNGAWFASTFNMDVNAYIGTVYTKTLYSVNAPIFQPQCWSFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2RJK1</accession>
    <name>M2RJK1_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">COCSADRAFT_33812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD66884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007696462.1">
        <property type="nucleotide sequence ID" value="XM_007698272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RJK1"/>
    <dbReference type="STRING" id="665912.M2RJK1"/>
    <dbReference type="GeneID" id="19137317"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33812"/>
    <dbReference type="eggNOG" id="ENOG502SJ0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115019_0_0_1"/>
    <dbReference type="OMA" id="GIRRWTQ"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMD66884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="145" mass="17005" checksum="3EAC2F2BF83C2B24" modified="2013-05-01" version="1">MSGLPSEPQQSRYLCLTICGYRKPGMNEEDYRDHMINVSAPLTKDLMVKYGIRRWTQIHNQSATRALMSQLFDPQMVHLADFDCFSQVVFKSVDDYVRMKQDPWYKEHLVGDHEKFADTKKSMMTIGWIEEFIDDGKVVEANKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2RLI9</accession>
    <name>M2RLI9_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_81655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697150.1">
        <property type="nucleotide sequence ID" value="XM_007698960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RLI9"/>
    <dbReference type="GeneID" id="19140846"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_81655"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005043_1_0_1"/>
    <dbReference type="OMA" id="FNTWHYG"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF89">
        <property type="entry name" value="ALPHA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="194"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="506"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="6">
        <location>
            <begin position="614"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD67509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="838" mass="95053" checksum="7F6A946CF82F8976" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2RLK7</accession>
    <name>M2RLK7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_352483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445639">
        <property type="protein sequence ID" value="EMD67524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007697162.1">
        <property type="nucleotide sequence ID" value="XM_007698972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RLK7"/>
    <dbReference type="STRING" id="665912.M2RLK7"/>
    <dbReference type="GeneID" id="19138157"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_352483"/>
    <dbReference type="eggNOG" id="KOG0589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="QNIMVHE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF25">
        <property type="entry name" value="PROTEIN KINASE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD67524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="208" mass="24053" checksum="86C2AB7801DCD269" modified="2013-05-01" version="1" fragment="single">MPFKHIRKIGQDGSAVIKMVSHAFTNQIFALKTFRRYNRRQFEGVKRVFINEISIMRRLSSHLHIIQLRGSYICDRELFILLRPVADGGDLAAYITRVLESGLLSEQEIILNRAFGCLADGLAFIHKHTIRHKDIKPQNIMVHEGRVLYTDFGISFDADQHDTTTVGCPVLFTRRYCAPEVKDWANRNRKWDVYSLGCVYLEILDALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2RNA0</accession>
    <name>M2RNA0_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_33058</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445638">
        <property type="protein sequence ID" value="EMD68094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007695441.1">
        <property type="nucleotide sequence ID" value="XM_007697251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RNA0"/>
    <dbReference type="STRING" id="665912.M2RNA0"/>
    <dbReference type="GeneID" id="19137019"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_33058"/>
    <dbReference type="eggNOG" id="KOG2056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012678_0_0_1"/>
    <dbReference type="OMA" id="PPNHTGY"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
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        <property type="entry name" value="EPSIN-1-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="10"/>
            <end position="143"/>
        </location>
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        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
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            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
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            <begin position="285"/>
            <end position="481"/>
        </location>
    </feature>
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        <location>
            <begin position="555"/>
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        </location>
    </feature>
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        <location>
            <begin position="167"/>
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        </location>
    </feature>
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            <begin position="201"/>
            <end position="218"/>
        </location>
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            <begin position="285"/>
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        </location>
    </feature>
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            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
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        </location>
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            <end position="593"/>
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    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="EMD68094.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="593" mass="66614" checksum="E193A379820D8E5B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2RQ41</accession>
    <name>M2RQ41_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">Protein SDS23</fullName>
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        <alternativeName>
            <fullName evidence="5">Protein sds23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">COCSADRAFT_109494</name>
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    <organism evidence="13 14">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <text evidence="1 9">Involved in DNA replication and cell separation.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SDS23 family.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
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        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="194"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="269"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="469"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMD68689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="535" mass="57149" checksum="1413AF6EB27BAAD9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2RR29</accession>
    <name>M2RR29_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">COCSADRAFT_194916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
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                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
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                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
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        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
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                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Turgeon B.G."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="KEGG" id="bsc:COCSADRAFT_32308"/>
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    <dbReference type="InterPro" id="IPR020846">
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        <location>
            <begin position="64"/>
            <end position="88"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="153"/>
            <end position="174"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="186"/>
            <end position="204"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="216"/>
            <end position="236"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="277"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="367"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="473"/>
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        <location>
            <begin position="25"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_007707645.1"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_003487_2_1_1"/>
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        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
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        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2RT43</accession>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="KB445637">
        <property type="protein sequence ID" value="EMD69734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007694971.1">
        <property type="nucleotide sequence ID" value="XM_007696781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RT43"/>
    <dbReference type="STRING" id="665912.M2RT43"/>
    <dbReference type="GeneID" id="19134448"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_213408"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_1_0_1"/>
    <dbReference type="OMA" id="QAYDLEY"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="93"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMD69734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="229" mass="24042" checksum="3F46FB91E5061711" modified="2013-05-01" version="1">MSAPHDSAAVQSNSVNTTTPASSQVESTNNGPSQGGLSTSSASTAAELASLKSTLKSSLRQFPDFPKPGILFEDIMPLFANPQLHESLVRGLELAVEQHFSASGKPDVIVGLDARGFLFGPSLALRIGASFVPVRKKGKLPGPCETAEYEKEYGSDFFQMQTDAVKSGQKVLVVDDIIATGGSAVAAGSLVTKLGGTVVGYLFLDEVPFLKGRDKLNAPVYTLLANPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2RU87</accession>
    <name>M2RU87_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_41841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445655">
        <property type="protein sequence ID" value="EMD58738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705606.1">
        <property type="nucleotide sequence ID" value="XM_007707416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RU87"/>
    <dbReference type="GeneID" id="19140094"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_41841"/>
    <dbReference type="eggNOG" id="ENOG502TJH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_940438_0_0_1"/>
    <dbReference type="OMA" id="DKAWLEW"/>
    <dbReference type="OrthoDB" id="3788651at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD58738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="281" mass="32037" checksum="97D1FE7E9E5C7E7E" modified="2013-05-01" version="1">MGHFEFRELGAICNYMRSKYEERAETKGKRRRSMSDTVTERKQKYGKLHKPPTVQSLHQRQDRSRSRLQKSRPQSMMSLAQPLPNLFVLEYDPYPYNTQPCQFLGVFSSIDTVTAGAFQHGAYSFSREGLLDGSEYLSPTGRIKIVSHPLQSTGVTATVPGETSKKDGQHMRLDIPHPLSQPVPRFDSHQDLNMPKRSEVTVYLALHESPNTAFCIGLFTSKSLAWGACLKDKAWLEWTDKVVEQKRDVGENNLPRIEGRLVGSGRHVWYVKESIVNDVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2RUL7</accession>
    <name>M2RUL7_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">COCSADRAFT_102763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB445654">
        <property type="protein sequence ID" value="EMD58833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007705317.1">
        <property type="nucleotide sequence ID" value="XM_007707127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RUL7"/>
    <dbReference type="GeneID" id="19129815"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_102763"/>
    <dbReference type="eggNOG" id="ENOG502SV9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_6_0_1"/>
    <dbReference type="OMA" id="LYCYACH"/>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF33">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMD58833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="258" mass="28918" checksum="31A1BFD870F131FD" modified="2013-05-01" version="1">MPSSKTFPAITGGCVCGTVRYRLLTSPLFCYACHCTNCRAFSGSAFGLFLKIEMYNVKVISSTLPAFVKTNNRRGAVEVHAECSACRVHMWVTSNFPGEEAVYDVRVGTLDFPDLMVPDLHIFAQSKLGWIRLPDDAHTLPRGGDMHKLWPKSSLERLEQCNRWADMMKKRKRAALVESKATAKSTEEGSGEETGGEGDKTPTALEFSNEDDEEFEKRFKEKEKILLERLEKLQLKLNEDEVKAGEQKAVESAETDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445652">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RXN1"/>
    <dbReference type="GeneID" id="19135290"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_254555"/>
    <dbReference type="HOGENOM" id="CLU_1906559_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMD59818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="133" mass="14855" checksum="21979C18EC05F354" modified="2013-05-01" version="1">MKKALNGRREKWGGAHTQVNHSLSLSLSLFSLSLLLIRSDHHRSLSSGTHLPPELRKCQVFFFFGQLCNYDQVVICRLTETDDAKRATLGPGPRGNYPISLLPTSGKTNDGPFCKRWNGNWVKSEPNLGKSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2RZC8</accession>
    <name>M2RZC8_COCSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">COCSADRAFT_163737</name>
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    <organism evidence="4 5">
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        <name type="common">Common root rot and spot blotch fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cerato-ulmin hydrophobin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMD60403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_007703765.1">
        <property type="nucleotide sequence ID" value="XM_007705575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2RZC8"/>
    <dbReference type="STRING" id="665912.M2RZC8"/>
    <dbReference type="GeneID" id="19132266"/>
    <dbReference type="KEGG" id="bsc:COCSADRAFT_163737"/>
    <dbReference type="eggNOG" id="ENOG502SUV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141181_0_0_1"/>
    <dbReference type="OMA" id="PFAMTET"/>
    <dbReference type="OrthoDB" id="4500971at2759"/>
    <dbReference type="Proteomes" id="UP000016934">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23508">
        <property type="entry name" value="hydrophobin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.120.10">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010636">
        <property type="entry name" value="Class_II_hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036686">
        <property type="entry name" value="Class_II_Hydrophobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341:SF1">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06766">
        <property type="entry name" value="Hydrophobin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydrophobin II, HfbII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004024512" description="Hydrophobin" evidence="3">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMD60403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="11976" checksum="F270F8FDFE0B1295" modified="2013-05-01" version="1">MRYTILAFAIGATAAPLTGYPSAVCPPGLYSTPQCCATDILGAAALNCKAPATTPTSTNQLISGCAATGQQAKCCVIPVAGQALLCQDVSPGANGGNNAGANGSNNGGANGSNNGGANGGNNGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2S4C1</accession>
    <name>M2S4C1_COCSN</name>
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        <recommendedName>
            <fullName evidence="4">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">COCSADRAFT_173412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB445647">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG1674">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <location>
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            <end position="137"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMD62018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="48379" checksum="2FB8B5446A5C51C8" modified="2013-05-01" version="1">MFGGASSHQQTPESSTAQHTPVRPSPSPSANAPRVGAPSADVPMADSGAPQSSSTPSQRSQQHNSSHLSASTGSAPSAAQAPASPCFRPHSQQSTPSGSNPASGAFTNTRTIPSTGLAPVQPSPAQSLRSPAPSPNRIKVKSLSHIQSFALDDSSPFSQSRSLARRHRRDPADVGPQYEISEMPVSDIIEMVAGLLTKITTTNDRQHDHLHRQIPPPEGTSGLSQQTTSVLAFHGKNVPSISILSYLSRIHKYCPTTYEVFLSLLVYFDRMTERVNAGPISGLRKANQQSVERSRSALSATPTSTDGVQSESASAQAATPPPSGSLGKVAGTPAEGPQPPSPPQQDLHADTALNLSHFFVVDSFNIHRLVIAGVTCASKFFSDVFYTNSRYAKVGGLPLVELNHLELQFLLLNDFRLAVPLEEMEAYGTMLVEFYAREVAEQHEKEQSARHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2S4U1</accession>
    <name>M2S4U1_COCSN</name>
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        <recommendedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">COCSADRAFT_147684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
                <person name="Turgeon B.G."/>
            </authorList>
            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001144">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="228"/>
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        </location>
    </feature>
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            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="423"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="729"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMD62178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016934"/>
        </source>
    </evidence>
    <sequence length="908" mass="98807" checksum="4AEF94BCA99A17CA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2S5K1</accession>
    <name>M2S5K1_COCSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">COCSADRAFT_162018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cochliobolus sativus (strain ND90Pr / ATCC 201652)</name>
        <name type="common">Common root rot and spot blotch fungus</name>
        <name type="synonym">Bipolaris sorokiniana</name>
        <dbReference type="NCBI Taxonomy" id="665912"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Pleosporineae</taxon>
            <taxon>Pleosporaceae</taxon>
            <taxon>Bipolaris</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <source>
            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23357949"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003233"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
        </source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
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                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Baker S.E."/>
                <person name="Ciuffetti L.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ND90Pr / ATCC 201652</strain>
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    <sequence length="149" mass="15822" checksum="A426CFD50411CCFF" modified="2013-05-01" version="1">MPRDCSSHIPVLYLHSIVLSPINLVSAALIPAPRNNLNAKRLEQNLGQRANATFSSQMCQTSESPKLQASARALHRTSGVVCVITFPKGALSPMVLTAGVARNTSQGRIAGRTQIDFVPGSPANALRVRFGFAIRSTQVIFLLGGSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ND90Pr / ATCC 201652</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2013" name="PLoS Genet." volume="9" first="E1003233" last="E1003233">
            <title>Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens.</title>
            <authorList>
                <person name="Condon B.J."/>
                <person name="Leng Y."/>
                <person name="Wu D."/>
                <person name="Bushley K.E."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R."/>
                <person name="Martin J."/>
                <person name="Schackwitz W."/>
                <person name="Grimwood J."/>
                <person name="MohdZainudin N."/>
                <person name="Xue C."/>
                <person name="Wang R."/>
                <person name="Manning V.A."/>
                <person name="Dhillon B."/>
                <person name="Tu Z.J."/>
                <person name="Steffenson B.J."/>
                <person name="Salamov A."/>
                <person name="Sun H."/>
                <person name="Lowry S."/>
                <person name="LaButti K."/>
                <person name="Han J."/>
                <person name="Copeland A."/>
                <person name="Lindquist E."/>
                <person name="Barry K."/>
                <person name="Schmutz J."/>
                <person name="Bake